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Analytical Methods for Determination of Apigenin - An Update 测定芹菜甙元的分析方法 - 最新进展
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240825
V. Suvarna, Shrutee Pawar, Janavi Sosa
Apigenin is a flavone abundantly present in various plants such as cherries, broccoli, legumes, parsley, and chamomile. In present article different analytical methods reported in various scientific studies for quantification and detection of apigenin in different formulations are presented. Various databases such as Science Direct, Pubmed Medical Subject Headings and Google scholar were used to retrieve the journal articles. Reported analytical methods for apigenin includes HPLC, UHPLC, HPTLC, TLC, GC, and capillary electrophoresis with MS, UV, PDA, and DAD detection. HPLC- MS was found to be frequently used for apigenin detection.Key words: apigenin, analytical method, flavone, chromatography.
芹菜素是一种黄酮,大量存在于樱桃、西兰花、豆类、欧芹和洋甘菊等多种植物中。本文介绍了各种科学研究中报道的用于定量和检测不同配方中芹菜素的不同分析方法。检索期刊论文时使用了各种数据库,如 Science Direct、Pubmed Medical Subject Headings 和 Google scholar。已报道的芹菜素分析方法包括 HPLC、UHPLC、HPTLC、TLC、GC 和毛细管电泳,以及 MS、UV、PDA 和 DAD 检测。HPLC-MS是芹菜素检测的常用方法。
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引用次数: 0
Toxicological Investigations of Plants Traditionally used for Mosquito Control in Kenya’s South Coast 肯尼亚南海岸传统用于控制蚊虫的植物毒理学调查
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240810
J. Musau
Background: Mosquito borne diseases affect many people globally and impede economic development. Plants are used for mosquito control since they are cost-effective, readily available and culturally acceptable.Objective: To investigate toxicological effects of plants use for mosquito control in Kenya’s south coast. Methods: Aqueous, acetone and hexane extract of L. camara (leaves), T. minuta (whole plant), A. indica (leaves), A. digitata (leaves), O. suave (whole plant) and P. barbatus (leaves) were tested for genotoxic potential using Allium cepa test. Acute dermal irritation and ocular toxicity were conducted as per OECD test guidelines. Results: There were significant differences among extracts and concentrations p<0.001. A. indica extracts showed a significant difference on root growth; P value for hexane was < 0.001, aqueous, 0.004 and acetone, 0.007. The roots were bent. A. indica showed most mitotic inhibition at concentration of 1mg/ml at 70.36±0.68 which was similar to vincristine sulphate. The least active was A. digitata at 1.42±0.68 at 0.125 mg/ml. Extracts of O. suave caused turgidity on the roots of Allium cepa. A. indica extracts had ghost cells(aqueous) and binucleate cells (acetone) while Aqueous extract of P. barbatus showed high cytoplasm to nucleus ratio.Conclusion: A. indica and P. barbatus extracts caused abnormal cells and it is possible for them to cause the same in human. None of the extracts exhibited dermal irritation or acute ocular toxicity. There was no significant change in weight of the test animals during the treatment period and there were no mortalities.Key words: genotoxic potential, Allium cepa test, mitotic inhibition, acute dermal irritation/corrosion, ocular toxicity
背景:蚊子传播的疾病影响着全球许多人,阻碍了经济发展。由于植物具有成本效益、易于获得且在文化上可以接受,因此被用于控制蚊虫:目的:调查肯尼亚南海岸用于控制蚊虫的植物的毒理学效应。方法:采用 Allium cepa 试验对 L. camara(叶片)、T. minuta(全株)、A. indica(叶片)、A. digitata(叶片)、O. suave(全株)和 P. barbatus(叶片)的水提取物、丙酮提取物和正己烷提取物进行基因毒性测试。急性皮肤刺激性和眼毒性测试按照经合组织测试指南进行。结果显示不同提取物和浓度之间存在明显差异,P<0.001。A. indica 提取物对根的生长有显著差异;正己烷提取物的 P 值<0.001,水提取物的 P 值为 0.004,丙酮提取物的 P 值为 0.007。根弯曲。当浓度为 1 毫克/毫升时,A. indica 对有丝分裂的抑制作用最强,为 70.36±0.68,与硫酸长春新碱相似。活性最低的是 A. digitata,0.125 毫克/毫升时为 1.42±0.68。O.suave的提取物会使薤白的根变硬。A.indica提取物有幽灵细胞(水提取物)和双核细胞(丙酮提取物),而P. barbatus的水提取物则显示出较高的细胞质与细胞核比率:结论:A. indica 和 P. barbatus 提取物会导致细胞异常,也有可能对人体造成同样的影响。没有一种提取物表现出皮肤刺激性或急性眼毒性。关键字:遗传毒性潜力、辣椒试验、有丝分裂抑制、急性皮肤刺激/腐蚀、眼毒性
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引用次数: 0
Premenstrual Syndrome in Female Physiotherapy Students and Its Effects on Life Quality 物理治疗专业女生的经前期综合征及其对生活质量的影响
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240803
Dency V. Bhut, Hemal Patel
Premenstrual Syndrome (PMS) is a common condition affecting many women. It includes various physical and emotional symptoms occurring before menstruation. This study explores how PMS affects the quality of life among female physiotherapy students.Introduction: Premenstrual Syndrome (PMS) is a widely recognized condition that can significantly impact the lives of many women during their reproductive years. It encompasses a range of physical and emotional symptoms that typically manifest in the two weeks leading up to menstruation.These symptoms can vary in severity and often disrupt daily routines and overall well-being. This study aims to understand how PMS impacts the quality of life of female physiotherapy students. Methodology: A survey of 135 female physiotherapy students , having age between 18 to 26 years, was conducted using premenstrual syndrome scale and WHOQOL-BREF . Participants were selected according to inclusion criteria and were made to fill google form questionnaires.Results: The data examination was performed with Microsoft Excel 2021. Out of 135 female physiotherapy students. The percentage of self- reported quality of life in study population was 72.59%.Conclusion: The quality of life in female physiotherapy students was affected.Key words: Premenstrual syndrome, female physiotherapy students, life quality
经前期综合症(PMS)是影响许多女性的一种常见病。它包括月经前出现的各种生理和情绪症状。本研究探讨了经前期综合症如何影响物理治疗专业女生的生活质量:经前期综合症(PMS)是一种广为人知的疾病,会严重影响许多育龄妇女的生活。它包括一系列生理和情绪症状,通常在月经来潮前两周表现出来。这些症状的严重程度各不相同,通常会扰乱日常生活和整体健康。本研究旨在了解经前期综合症如何影响物理治疗专业女生的生活质量。研究方法采用经前综合征量表和 WHOQOL-BREF 对 135 名年龄在 18 至 26 岁之间的物理治疗专业女学生进行了调查。根据纳入标准选择参与者,并让她们填写谷歌问卷:数据检查使用 Microsoft Excel 2021 进行。在 135 名物理治疗专业的女学生中。研究人群中自我报告生活质量的比例为 72.59%:结论:物理治疗专业女生的生活质量受到影响:经前期综合征、物理治疗专业女生、生活质量
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引用次数: 0
Impact of Junk Food on Dysmenorrhea in Young Aged Females of Ahmedabad City 垃圾食品对艾哈迈达巴德市年轻女性痛经的影响
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240802
Dhruvi S. Zalavadia, Amit M. Patel
BACKGROUND: Dysmenorrhea, or painful menstruation, is common among young females and can significantly affect their well-being. This study aims to explore the potential relationship between junk food consumption and severity of dysmenorrhea in young females residing in Ahmedabad city.INTRODUCTION: Painful menstruation, or dysmenorrhea, is a widespread concern affecting many young females. The discomfort associated with dysmenorrhea can range from mild inconvenience to severe pain. It is understood that dysmenorrhea can be influenced by various factors, including hormonal changes and lifestyle choices. One lifestyle aspect that has attracted attention in recent years is dietary habits, particularly the consumption of junk food. This study, set in Ahmedabad city, aims to shed light on the potential impact of junk food consumption on dysmenorrhea in young females.METHODOLOGY: A total of 100 female participants aged 18-25 were enrolled in the Ahmedabad city for the study. Participants were selected according to inclusion criteria, and were made to fill questionnaires which dealt with menstrual history, dietary habit and dysmenorrhea. Questionnaire was circulated through Google form. The intensity of pain was rated on numeric pain rating scale (NPRS).RESULT: SPSS version 29 software was used for data analysis. For the correlation between junk food habit and dysmenorrhea spearman rho test was applied. (r = 0.898 and p = <0.001)CONCLUSION: There is a significant correlation between junk food habit and dysmenorrhea among young females. Thus, the study suggests that subjects with higher junk food habit have severe dysmenorrhea.Key words: Dysmenorrhea, Junk food, Numeric Pain Rating Scale.
背景:痛经在年轻女性中很常见,会严重影响她们的健康。本研究旨在探讨垃圾食品消费与艾哈迈达巴德市年轻女性痛经严重程度之间的潜在关系。痛经带来的不适从轻微的不便到严重的疼痛不等。据了解,痛经可能受到多种因素的影响,包括荷尔蒙变化和生活方式的选择。近年来,饮食习惯,尤其是垃圾食品的摄入量是引起人们关注的生活方式之一。本研究以艾哈迈达巴德市为背景,旨在揭示食用垃圾食品对年轻女性痛经的潜在影响。根据纳入标准选择参与者,并让她们填写有关月经史、饮食习惯和痛经的调查问卷。问卷通过谷歌表格分发。结果:使用 SPSS 29 版软件进行数据分析。对垃圾食品习惯与痛经之间的相关性进行了 spearman rho 检验。(结论:年轻女性的垃圾食品习惯与痛经之间存在显著相关性。因此,该研究表明,有较多垃圾食品习惯的受试者痛经严重:痛经 垃圾食品 数字疼痛评分量表
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引用次数: 0
Effect of Loss of Lumbar Lordosis on Spinal Flexibility and Function 腰椎后凸对脊柱灵活性和功能的影响
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240820
Anupama Dhuria, Shallabh Kumar Singh
Lumbar lordosis, the natural inward curvature of the lower spine, is essential for balance and mechanical stress distribution. Loss of lumbar lordosis, or hypolordosis, can adversely affect spinal flexibility and function. This study examines the biomechanical and functional impacts of reduced lumbar curvature to inform clinical practices. This cross-sectional study included 60 subjects divided into three groups based on lumbar lordosis (LL) angles: Group A (LL < 10°), Group B (10° ≤ LL < 20°), and Group C (LL ≥ 20°). Inclusion criteria included adults aged 20-65 years with diagnosed hypolordosis, excluding those with severe spinal conditions, recent major spinal surgery, neurological disorders, severe comorbidities, and pregnancy. Clinical evaluations involved medical history, physical examination, and questionnaires (Visual Analog Scale for pain, Oswestry Disability Index). Radiographic measurements, Sit-and-Reach test for flexibility, Timed Up and Go (TUG) test, and 6-Minute Walk Test (6MWT) were conducted. Data were analyzed using ANOVA and Pearson’s correlation coefficient. Significant differences were observed between the groups (p < 0.001). Group A had the highest pain (VAS: 7.2 ± 1.5), disability (ODI: 45 ± 10%), and lowest flexibility (Sit-and-Reach: 5.0 ± 2.5 cm) and functional capacity (TUG: 14.5 ± 2.0 seconds, 6MWT: 300 ± 50 meters). Group B showed intermediate values, while Group C had the lowest pain (VAS: 4.2 ± 1.0), disability (ODI: 25 ± 7%), and highest flexibility and functional capacity (Sit-and-Reach: 12.0 ± 3.5 cm, TUG: 9.5 ± 1.2 seconds, 6MWT: 400 ± 40 meters). Loss of lumbar lordosis significantly impacts spinal biomechanics and function, with greater loss linked to higher pain, disability, and reduced flexibility and function. Maintaining lumbar curvature is crucial for improving patient outcomes. Further research should explore long-term corrective interventions.Key words: Lumbar lordosis, hypolordosis, spinal flexibility, spinal function, pain, disability, biomechanics, clinical management
腰椎前凸是下脊柱的自然内弯,对于平衡和机械应力分布至关重要。腰椎前凸或脊柱后凸的丧失会对脊柱的灵活性和功能产生不利影响。本研究探讨了腰椎弯曲度降低对生物力学和功能的影响,为临床实践提供参考。这项横断面研究包括 60 名受试者,根据腰椎前凸(LL)角度分为三组:A 组(LL < 10°)、B 组(10° ≤ LL < 20°)和 C 组(LL ≥ 20°)。纳入标准包括 20-65 岁确诊脊柱后凸的成年人,但不包括患有严重脊柱疾病、近期接受过重大脊柱手术、神经系统疾病、严重合并症和妊娠的患者。临床评估包括病史、体格检查和问卷调查(疼痛视觉模拟量表、Oswestry 残疾指数)。此外,还进行了放射学测量、坐立灵活性测试、定时起立行走(TUG)测试和 6 分钟步行测试(6MWT)。数据采用方差分析和皮尔逊相关系数进行分析。观察到各组之间存在显著差异(P < 0.001)。A 组的疼痛感(VAS:7.2 ± 1.5)和残疾程度(ODI:45 ± 10%)最高,柔韧性(坐立行走:5.0 ± 2.5 厘米)和功能能力(TUG:14.5 ± 2.0 秒,6MWT:300 ± 50 米)最低。B 组的数值居中,而 C 组的疼痛(VAS:4.2 ± 1.0)和残疾程度(ODI:25 ± 7%)最低,灵活性和功能能力(坐立行走:12.0 ± 3.5 厘米,TUG:9.5 ± 1.2 秒,6MWT:400 ± 40 米)最高。腰椎前凸的丧失会严重影响脊柱生物力学和功能,腰椎前凸的丧失越严重,疼痛、残疾以及灵活性和功能的降低就越严重。保持腰椎弧度对改善患者预后至关重要。进一步的研究应探索长期的矫正干预措施:腰椎前凸、脊柱后凸、脊柱灵活性、脊柱功能、疼痛、残疾、生物力学、临床管理
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引用次数: 0
Fortuitous Displacement of Maxillary Impacted Third Molar in Infra-temporal fossa: A Case Report 上颌第三磨牙在颞下窝的偶然移位:病例报告
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240816
Deepika Vyas, Ashish Vyas, Prafull Pujari
Impacted third molar surgery is one of the complicated dentoalveolar surgeries. By having appropriate safety measures these surgeries can be caried out without much complication. Removal of impacted third maxillary molar is frequently carried out without difficulties and low rate of intraoperative complications. Here we are presenting an uncommon case of an impacted maxillary third molar having peri-apical abscess that was unintentionally displaced into the infra temporal space during its extraction. Displaced tooth was retrieved from infratemporal fossa region under general anaesthesia. It is a very rare complication to be happen during routine surgical extraction of maxillary impacted third molar tooth.Key words: Maxillary third molar, Infra-temporal fossa, Displacement of tooth, Dentoalveolar surgery, Surgical Complication.
第三磨牙撞击手术是复杂的牙槽外科手术之一。只要采取适当的安全措施,这些手术就能顺利进行,不会出现太多并发症。上颌阻生第三磨牙的拔除手术通常不会遇到困难,术中并发症的发生率也很低。这里我们要介绍的是一例不常见的上颌第三磨牙在拔除过程中无意间移位到颞下间隙,并伴有根尖周围脓肿的病例。在全身麻醉的情况下,从颞下窝区取出了移位的牙齿。这是上颌第三磨牙常规拔除手术中非常罕见的并发症:上颌第三磨牙 颞下窝牙移位 牙槽外科手术 手术并发症
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引用次数: 0
Radicular Cyst in Deciduous Molars: An Infrequent Condition 乳臼齿根状囊肿:一种不常见的疾病
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240815
Aniket Desai, Prasad N Jathar, Shravani Peshave
Radicular cyst accounts for one of the most common odontogenic cysts of the jaw. However, its association with deciduous teeth is an infrequent phenomenon. The purpose of this article is to report a case of radicular cyst associated with non vital primary tooth. The treatment includes a conservative approach which is the technique of decompression following the extraction of the offending deciduous molar and preservation of the succedaneous tooth.Key words: case report, decompression, deciduous teeth, radicular cyst, stent
放射性囊肿是颌骨最常见的牙源性囊肿之一。然而,它与乳牙相关的现象并不多见。本文旨在报告一例与非重要基牙相关的放射性囊肿。治疗方法包括保守疗法,即在拔除病变乳磨牙后进行减压,并保留继发牙。 关键词:病例报告、减压、乳牙、根管囊肿、支架
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引用次数: 0
An Unusual Case of Biological Foreign Body of Quill of a Porcupine Animal in Foot 足部出现豪猪喙生物异物的罕见病例
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240817
Sudhir Kumar Jain, Rathindra Tripura, Mrunal Kshirsagar
Porcupine quill injuries are known for their potential complications due to the sharp and barbed nature of the quills. We present rare and unusual case of a 50-year-old male who presented with persistent pain, swelling, and redness over the right inner border of his foot following an accidental injury involving Indian porcupine quills. After failed multiple attempts of self-removal of superficially embedded quills, imaging studies revealed a retained foreign body. Surgical exploration under local anesthesia revealed a long, sharp porcupine quill penetrating to the subcutaneous plane. The quill was successfully extracted, and meticulous wound care was performed. The patient tolerated the procedure well and was discharged with instructions for postoperative wound management. This case underscores the importance of prompt diagnosis, surgical intervention, and comprehensive wound care in managing injuries caused by porcupine quills to prevent complications and ensure optimal outcomes.Key words: porcupine, quill, Indian species, animal
众所周知,由于豪猪刺锋利且带有倒刺,豪猪刺伤具有潜在的并发症。我们介绍了一例罕见的病例:一名 50 岁的男性因印度豪猪的刺意外受伤,导致右脚内侧出现持续性疼痛、肿胀和发红。在多次尝试自行取出浅表嵌入的箭刺失败后,影像学检查发现异物残留。在局部麻醉下进行手术探查,发现一根又长又尖的豪猪毛刺刺入皮下。患者成功取出了豪猪毛,并对伤口进行了精心护理。患者对手术的耐受性很好,出院时还得到了术后伤口处理的指导。本病例强调了及时诊断、手术干预和全面的伤口护理在处理豪猪毛造成的伤害方面的重要性,以防止并发症并确保最佳治疗效果。
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引用次数: 0
Exploring Cricket Injuries, Especially Side Strain, Among North Indian Club Cricketers: A Close Look 探讨北印度俱乐部板球运动员的板球伤病,尤其是侧拉伤:近距离观察
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240801
Abdul Hayul Qayoom Banday, Kavita Semwal, Shyam Koley
Objectives: This study investigates the prevalence, nature, and management of cricket-related injuries, with a special focus on side strains among club cricketers in North India. Cricket, a sport deeply ingrained in Indian culture, presents various physical challenges to players, particularly bowlers. Side strains, characterized by acute pain in the side muscles, often result from the repetitive and intense nature of cricketing actions such as bowling and batting. This study aims to identify common injury patterns, explore the existing management practices, and suggest improvements based on empirical evidence.Methods: For this purpose, randomly selected 206 club cricketers aged 18-35 years were collected from various cricket clubs in North India.Results: Our research involved a detailed survey and physical examination of club cricketers, focusing on their injury history and management practices. Findings revealed a high prevalence of side strains, especially among bowlers, and highlighted the inadequacies in current management strategies.Conclusion: The study underscores the need for improved injury prevention protocols and rehabilitation strategies to enhance player performance and longevity in the sport.Key words: Cricketers. Sports specific injuries. Side Strain
研究目的本研究调查了板球相关损伤的发生率、性质和处理方法,特别关注北印度俱乐部板球运动员的侧拉伤。板球是一项在印度文化中根深蒂固的运动,对球员,尤其是保龄球运动员的身体提出了各种挑战。侧拉伤的特点是侧部肌肉剧烈疼痛,通常是由于板球运动(如保龄球和击球)的重复性和激烈性造成的。本研究旨在确定常见的受伤模式,探索现有的管理方法,并根据经验证据提出改进建议:为此,我们从印度北部的多家板球俱乐部随机抽取了 206 名年龄在 18-35 岁之间的俱乐部板球运动员:我们的研究包括对俱乐部板球运动员的详细调查和身体检查,重点是他们的受伤史和处理方法。研究结果表明,侧拉伤的发病率很高,尤其是在保龄球运动员中,并突出了当前管理策略的不足之处:结论:这项研究强调了改进损伤预防方案和康复策略的必要性,以提高球员在这项运动中的表现和寿命:板球运动员。运动损伤。侧拉伤
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引用次数: 0
Neutrophil-Lymphocyte Ratio: Adjunct Prognostic Biomarker in Oral Squamous Cell Carcinoma (OSCC) – A Study in Delhi NCR 中性粒细胞-淋巴细胞比率:口腔鳞状细胞癌 (OSCC) 的辅助预后生物标志物--德里 NCR 地区的一项研究
Pub Date : 2024-08-08 DOI: 10.52403/ijhsr.20240824
Mihir Sharma, C. Agarwal, M. Pujani
Background: Inflammation is now recognized as the seventh hallmark of cancer. Neutrophil-lymphocyte ratio holds promise as an adjunct biomarker in various cancers.Materials and methods: 32 biopsy-confirmed OSCC patients and 32 healthy controls were enrolled in this prospective case-control study and venous blood samples were obtained and CBC reports were thus used for analysis of various haematological parameters such as NLR, using t-test, and Mann-Whitney U test using STATA. Results: The median NLR was found to be raised in OSCC patients as compared to healthy controls and the difference was found to be statistically significant ((Median:3.83(2.31-5.56) vs. 2.14(1.80-2.66), p=0.0006)Conclusions : NLR can be used as a useful tool for clinicians as an adjunct biomarker for the prognostication and potentially help in the diagnosis of OSCC in screening. Future studies should include a larger sample size and should be longitudinal in nature as well as should explore differences in NLR in benign, premalignant and malignant cases.Key words: Neutrophil-lymphocyte ratio, biomarker, oral squamous cell carcinoma, cancer, hematological
背景:炎症现已被认为是癌症的第七大标志。材料与方法:这项前瞻性病例对照研究招募了 32 名经活检确诊的 OSCC 患者和 32 名健康对照者,并采集了静脉血样本和 CBC 报告,使用 t 检验和 STATA 的 Mann-Whitney U 检验分析 NLR 等各种血液学参数。结果:与健康对照组相比,OSCC 患者的 NLR 中位数升高,差异具有统计学意义(中位数:3.83(2.31-5.56) vs. 2.14(1.80-2.66), p=0.0006):NLR可作为临床医生预后的辅助生物标志物,并有可能帮助筛查诊断OSCC。未来的研究应包括更大的样本量、纵向研究以及探讨良性、恶性前和恶性病例中 NLR 的差异:中性粒细胞-淋巴细胞比值 生物标志物 口腔鳞状细胞癌 癌症 血液学
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引用次数: 0
期刊
International Journal of Health Sciences and Research
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