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Assessment of Platelet Rich Plasma (PRP) In the Treatment of Primary Osteoarthritis Knee: An Original Research 富血小板血浆(PRP)治疗原发性膝骨关节炎的评估:一项原创性研究
Pub Date : 2023-03-21 DOI: 10.32553/ijmbs.v7i3.2684
Rompilli Joshua, Kalidindi Varun Varma, S. Kumar Reddy, DR Rehan Saifuddin DR Rehan Saifuddin4
Introduction: The present therapeutic line of osteoarthritis of knee is primarily symptomatic, therefore the need to discover treatment modality which tackles the disease process in itself. This study was done with an intention to examine the efficacy of platelet rich plasma in primary osteoarthritis of knee. Materials and Methods: This prospective investigation was done on 100 knees in 100 individuals having early primary osteoarthritis of the knee. Three injections of platelet rich plasma were administered at four weeks interval and the outcome was analyzed by WOMAC and VAS score at pre injection, 3 weeks, 12 weeks and 24 weeks. Ahlback’s grading was done at pre-injection and at 6 months. Results: Most of the cases in our series were in the age category of 50-65 years with female predominance (73%), 51% cases had grade 2 disease and the remaining had grade 1 involvement. Improvement in WOMAC score parameters started after 3 weeks with continuing improvement at successive follow-ups. WOMAC score parameters (pain, stiffness, physical function and total score) at pre injection were 14.22, 5.05, 36.41and 55.8 and at 6 months follow up were 5.92, 2.07, 16.78 and 24.11 correspondingly. Similar improvement was noted in VAS score with pre injection score of 7.12 and final score of 2.96. The average WOMAC score was less for grade 1 as compared to grade 2 (43.42 vs 60.41); (43.63 vs 61.36). Improvement was reported in 86% of patients however the level varied from good to slight improvement. There was no problem associated to the treatment in our series. Conclusion: The initial data show that PRP is an effective therapeutic strategy in early grades of primary Osteoarthritis of knee. However, further strong evidence Research is required to check for the long-term impacts and to corroborate the conclusions of this investigation. Keywords: , , , 
导言:目前膝关节骨关节炎的治疗路线主要是对症治疗,因此需要发现治疗方式来解决疾病本身的过程。本研究旨在探讨富血小板血浆治疗原发性膝关节骨关节炎的疗效。材料和方法:本前瞻性研究在100例早期原发性膝关节骨性关节炎患者的100例膝关节上进行。每隔四周注射3次富血小板血浆,分别在注射前、3周、12周和24周用WOMAC和VAS评分分析结果。Ahlback评分分别在注射前和注射6个月时进行。结果:我们研究的大多数病例年龄在50-65岁之间,以女性为主(73%),51%为2级病变,其余为1级病变。WOMAC评分参数在3周后开始改善,并在后续随访中持续改善。注射前WOMAC评分参数(疼痛、僵硬、身体功能和总分)分别为14.22、5.05、36.41和55.8,随访6个月时分别为5.92、2.07、16.78和24.11。VAS评分也有类似改善,注射前评分为7.12,注射后评分为2.96。1级患者的平均WOMAC评分低于2级患者(43.42 vs 60.41);(43.63 vs 61.36)。86%的患者报告改善,但改善程度从良好到轻微改善不等。在我们的研究中,没有出现与治疗相关的问题。结论:初步资料显示PRP是治疗早期原发性膝骨关节炎的有效方法。然而,需要进一步的有力证据研究来检查长期影响并证实本调查的结论。关键词:,,,
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引用次数: 0
PREVALENCE OF MAXILLOFACIAL TRAUMA WITH FRONTAL FRACTURE AT HASAN SADIKIN GENERAL HOSPITAL BANDUNG 万隆哈桑萨迪金总医院颌面外伤伴额部骨折的患病率
Pub Date : 2023-02-20 DOI: 10.32553/ijmbs.v7i2.2668
Muhammad Adri Nurrahim, E. Sjamsudin, A. Arumsari
Patients with maxillofacial fractures have a high risk of accompanying head injury because of the close anatomical location of facial bones and cranium. Forces striking the face are transmitted directly to the neurocranium, resulting in more severe brain injury. Objective: To analyze the prevalence of patients with maxillofacial fractures with frontal fractures at RSHS Bandung in 2020. Methods: Descriptive study of medical records of maxillofacial trauma patients with frontal fractures at Hasan Sadikin Hospital, Bandung, January-December 2020. The data collected included gender, age, aetiology and location of the fracture. Results: The majority gender was 79.8% male, while the female was only 20.2%. The age range is 17-25 years old (36%). Most fracture locations were maxillofacial trauma without frontal fracture (92.2%), compared to maxillofacial fracture with frontal fracture as much as 10%. The most common trauma etiology was Traffic accidents (81.3%), followed by falls as much as 17.8%, and physical violence 0.7%. Conclusion: Maxillofacial trauma with frontal fracture has relatively few incidences, and the primary aetiology is Traffic accidents in young adults.  
由于面骨与头盖骨的解剖位置较近,颌面部骨折患者伴发头部损伤的风险较高。撞击脸部的力会直接传递到神经头盖骨,导致更严重的脑损伤。目的:分析2020年万隆RSHS颌面骨折合并额部骨折患者的患病率。方法:对2020年1月- 12月万隆哈桑萨迪金医院颌面部创伤合并额部骨折患者的病历进行描述性研究。收集的数据包括性别、年龄、病因和骨折位置。结果:男性占79.8%,女性占20.2%;年龄范围为17-25岁(36%)。骨折部位以颌面部外伤无额骨折居多(92.2%),而颌面部骨折伴额骨折则高达10%。最常见的创伤原因是交通事故(81.3%),其次是跌倒(17.8%)和身体暴力(0.7%)。结论:颌面部外伤合并额部骨折发生率相对较低,主要病因为交通事故。
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引用次数: 0
A Prospective Comparative Study of Removal of Urinary Catheter at 12 hours versus at or >24 Hours Following Elective Cesarean Section in Women 选择性剖宫产术后12小时与>24小时拔除导尿管的前瞻性比较研究
Pub Date : 2023-02-17 DOI: 10.32553/ijmbs.v7i1.2669
Dr Aditi Jain, Dr. Lata Ratanoo, D. S. Kumari, Dr. Neelam Bharadwaj, Dr. Pawan Agarwal, Dr. Geetika Sharma, Dr. Indu Gautam, Dr. Harshita Khandelwal
Background & Objective: To compare the outcomes of urinary catheter removal at 12 Hours versus at or >24 Hours post elective cesarean section. To assess and compare symptomatic UTI, time of ambulation, length of hospital stays and need for recatherization amongst these 2 groups. Methods: In all patients undergoing elective primary cesarean section,  Preoperative urine routine and microscopy¯ were sent, UTI was ruled out, clinical examination was performed and were NPO at least 8 hours prior to surgery and given antibiotics. A foley catheter was inserted on the operating table immediately before starting cesarean section. Cesarean sections were performed in the usual manner under spinal anesthesia. After this, in Group 1 patients, catheter were removed 12hours post-operatively while in Group 2 it was removed 24 hours post-operatively.  After catheter removal, women were encouraged to void and helped to ambulate. Results: 2 groups were compared and the overall rates of post caesarean section urinary complaints dysuria (8.69%), urinary frequeny(14.13%), urgency(10.86%), burning micturition(9.76%) were higher in 24 hours catheter removal group. The Mean duration of first Post-op voiding time (4 hours), ambulatory time(4 hours) and hospital stay(4 days) were shorter in 12 hours catheter removal group. Conclusion: Urinary catheter removal post Caesarean section at duration of 12 hours postoperatively is associated with decreased complications and morbidity in post Caesarean section women.
背景与目的:比较择期剖宫产术后12小时和>24小时拔除导尿管的效果。评估和比较两组患者的症状性尿路感染、活动时间、住院时间和再动脉粥样硬化必要性。方法:所有择期剖宫产患者术前行尿常规及镜检,排除尿路感染,行临床检查,术前至少8小时NPO并给予抗生素治疗。在开始剖宫产手术前,立即在手术台上插入foley导管。在脊髓麻醉下按常规方式进行剖宫产。之后,组1术后12小时拔除导管,组2术后24小时拔除导管。拔除导管后,鼓励妇女排空并帮助她们走动。结果:两组比较,24 h拔管组剖宫产术后尿诉排尿困难(8.69%)、尿频(14.13%)、尿急(10.86%)、灼烧排尿(9.76%)的总体发生率均高于拔管组。12 h拔管组术后平均首次排尿时间(4小时)、平均门诊时间(4小时)和平均住院时间(4天)均较短。结论:剖宫产术后12小时拔除导尿管可降低剖宫产术后患者的并发症和发病率。
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引用次数: 0
Management of mandibular fracture and lacerated wound due to machete trauma in children: case report 儿童砍刀所致下颌骨骨折及撕裂伤的处理:1例报告
Pub Date : 2023-02-11 DOI: 10.32553/ijmbs.v7i1.2650
Saptiadi Oktora, Eka Marwansyah Oli’i, D. Maifara
Introduction: The facial fractures in pediatric patients are rare, and they need an immediate treatment to recover the function and aesthetic to the young patients. Anatomic reduction along with rigid skeletal stabilization is mandatory until bone union has occurred. Special consideration about variation in anatomy and physiology of pediatric patients, as well as the particular stage of growth and dental development should be preferred. Case report: We present a case of 5 year old girl patient with fractures of the parasymphyseal and left angle of mandible horizontally and vertically unfavourable, with significant displacement and huge lacerated wound of the face caused by machete slashed. We successfully managed the pediatric complex mandible fractures by performing open reduction internal fixation using resorbable miniplates and gunning splint as intermaxillary fixation. Conclusion: Pediatric mandible fractures requiring ORIF are rare. The combination of intermaxillary fixation and resorbable fixation system is needed postoperatively because of the extensive fractures for adequate fixation and good outcomes.
前言:小儿面部骨折是罕见的,需要立即治疗,以恢复功能和审美的年轻患者。解剖复位和刚性骨骼稳定是强制性的,直到骨愈合发生。特别考虑到儿童患者的解剖和生理变化,以及生长和牙齿发育的特殊阶段应优先考虑。病例报告:我们报告了一例5岁的女孩,她的副椎管和下颌骨左角骨折水平和垂直不利,面部有明显的移位和巨大的割伤伤口,是由砍刀划伤引起的。我们采用可吸收微型钢板和gunning夹板进行开放复位内固定,成功地治疗了儿童复杂的下颌骨骨折。结论:小儿下颌骨骨折需要ORIF治疗的病例很少。由于广泛的骨折,术后需要颌间固定和可吸收固定系统的结合,以获得充分的固定和良好的效果。
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引用次数: 0
Emergency Treatment of Soft Tissue and Dentoalveolar Fractures using Risdon Wiring in Children due to Motorcycle Accident : Case Report 摩托车事故儿童软组织及牙槽骨骨折急诊应用Risdon钢丝治疗一例报告
Pub Date : 2023-02-06 DOI: 10.32553/ijmbs.v7i1.2663
E. Sjamsudin, Harmas Yazid Y, A. Tasman, Winarno Priyanto
Introduction: Dentoalveolar fractures are often found in children due to physical trauma, falls, and motorized accidents. In pediatric patients, there are variations in age, jaw development, and dentition which are the primary considerations in choosing a dentoalveolar fracture treatment method. This case report aims to describe and discuss the emergency management of soft tissue injuries and mandibular dentoalveolar fractures with Risdon wiring in pediatric patients due to motorized accidents.Case report: A 9-year-old female patient complained of bleeding from the mouth due to a traffic accident. Clinical and radiographic examination showed dentoalveolar segment fractures in tooth region 32-42, stab wounds, and lacerations on the inferior lip, vestibule, and gingiva in tooth region 32-42. The patient underwent wound cleaning, wound suturing, and treatment of dentoalveolar fractures with fixation using Risdon wiring in the mandibular region 36-46.Conclusion: Conservative treatment of dentoalveolar fractures in pediatric patients with minimal intervention can give good results. Risdon wiring as a fixation method can be used in the emergency treatment of dentoalveolar fractures in pediatric patients with mixed dentition.Keywords: Soft tissue trauma, dentoalveolar fracture, Risdon wiring, emergency
儿童牙槽骨骨折常因身体创伤、跌倒和机动事故而发生。在儿科患者中,年龄、颌骨发育和牙列的差异是选择牙槽骨骨折治疗方法的主要考虑因素。本病例报告旨在描述和讨论儿童因机动事故导致的软组织损伤和下颌牙槽骨折的急诊处理。病例报告:一名九岁女病人自诉因交通事故口腔出血。临床及影像学检查显示32-42牙区牙槽段骨折,32-42牙区有刀伤及下唇、前庭及牙龈撕裂伤。患者接受了伤口清洗,伤口缝合,并在下颌骨使用Risdon钢丝固定治疗牙槽骨骨折36-46。结论:儿童牙槽牙槽骨折采用微创保守治疗可取得较好的疗效。Risdon钢丝作为一种固定方法可用于小儿混合牙列患者牙槽骨折的急诊治疗。关键词:软组织创伤,牙槽骨骨折,里斯顿钢丝,急诊
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引用次数: 0
Emergency Management of Maxillofacial Soft Tissue Wounds due to Physical Trauma 物理创伤所致颌面部软组织创伤的急救处理
Pub Date : 2023-02-06 DOI: 10.32553/ijmbs.v7i1.2657
Deddy dwi Septian, M. Sundari, E. Sjamsudin, M. Sylvyana, Eka Marwansyah Oli’i
Introduction: Soft tissue trauma is common in the head and neck, limited to superficial structures or involving deeper anatomical structures. Various types of trauma occur depending on the aetiology and mechanism. Managing oral and maxillofacial soft tissue trauma poses a challenge for surgeons due to the importance of facial esthetics. The purpose of this case report is to report and discuss the emergency management of soft tissue injuries in the maxillofacial region due to physical trauma. Case report: Three cases with diagnoses of abrasive wounds, lacerations, and punctum wounds on the lips, cheeks, eyebrows, chin, and oral cavity were encountered at the emergency department of Hasan Sadikin Hospital, Bandung City, due to a motor accident. Treatment includes debridement, reconstruction, and wound closure.Conclusion: Emergency treatment of soft tissue wounds in the maxillofacial area that is fast and according to the procedure will reduce infection and dehiscence.Keywords: emergency, soft tissue injury, Maxillofacial, Physical trauma
简介:软组织创伤常见于头颈部,局限于浅表结构或累及深层解剖结构。不同类型的创伤取决于病因和机制。由于面部美学的重要性,处理口腔颌面软组织创伤对外科医生提出了挑战。本病例报告的目的是报告和讨论由于物理创伤导致的颌面部软组织损伤的急救处理。病例报告:在万隆市Hasan Sadikin医院的急诊科遇到了三例因车祸而被诊断为嘴唇、脸颊、眉毛、下巴和口腔的磨蚀性伤口、撕裂伤和点状伤口。治疗包括清创、重建和伤口愈合。结论:颌面部软组织创面急诊治疗快速、按程序处理可减少感染和开裂。关键词:急诊;软组织损伤;颌面
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引用次数: 0
Hypertriglyceridemia-induced Acute Pancreatitis in Diabetic Population 糖尿病人群中高甘油三酯血症诱发的急性胰腺炎
Pub Date : 2023-02-04 DOI: 10.32553/ijmbs.v7i1.2659
Giovanni Reynaldo, Pingkan Naomi, Christina Permata Shalim
Hypertriglyceridemia induced acute pancreatitis has become the third major cause of acute pancreatitis resulting in high morbidity and mortality. Currently, specific mechanism behind association between hypertriglyceridemia in diabetic population and the correlation of causing acute pancreatitis are still not well identified. This literature review summarizes recent understanding of the pathogenesis of hypertriglyceridemia in diabetic populations and its correlation with acute pancreatitis along with clinical management of this disease.Keywords: Hypertriglyceridemia, Pancreatitis, Diabetic Population
高甘油三酯血症引起的急性胰腺炎已成为急性胰腺炎的第三大病因,具有很高的发病率和死亡率。目前,糖尿病人群高甘油三酯血症与引起急性胰腺炎相关的具体机制尚不清楚。本文综述了近年来对糖尿病人群高甘油三酯血症发病机制及其与急性胰腺炎的关系以及该疾病的临床治疗的认识。关键词:高甘油三酯血症,胰腺炎,糖尿病人群
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引用次数: 0
A Rare Case of Scar Edometriosis - Case Report 瘢痕性子宫内膜异位症1例报告
Pub Date : 2023-01-23 DOI: 10.32553/ijmbs.v7i1.2654
Dr. L Sridhar, Dr. Abhilash Reddy K., Dr. Bhaswanth Dhoorjati, Dr. Rohit Phadnis
Background: Scar endometriosis is a rare condition seen in post LSCS or hysterectomy or obstetric procedure, where functional endometrial tissue is seen outside uterine cavity. Case: A 34 year old female presented with cyclic pain during menstruation at the Pfannenstiel incision at the scar site, associated with 5 * 5 cm lump in the parietal abdominal plan. On clinical examination and investigations, preoperatively, it was suggestive of scar endometriosis. After excision, HPE confirmed to be scar endometriosis with 2 cm clear margins. Discussion: Scar endometriosis is a very rare disorder whose incidence was reported to be 0.03–0.45%. Clinical suspicion of scar endometriosis is very important in the patients with chronic pain at scar site, which is usually missed and can often lead to longterm morbidity of the patients. With histopathological confirmation it becomes absolutely necessary to prove iatrogenic implantation theory which is well accepted. Conclusion: Clinical suspicion of scar endometriosis depending on clinical presentation and history of previous obstetric procedure   is important for surgeons and excision of the lesion with good margins is the treatment of choice to prevent chronic morbidity in patients due to pain and recurrent surgery.
背景:瘢痕性子宫内膜异位症是一种罕见的情况,见于LSCS或子宫切除术或产科手术后,在子宫腔外可见功能子宫内膜组织。病例:一名34岁女性,在瘢痕部位的Pfannenstiel切口处出现月经周期疼痛,并伴有腹壁平面5 * 5cm肿块。经临床检查及术前检查,提示瘢痕性子宫内膜异位症。切除后,HPE证实为瘢痕性子宫内膜异位症,边缘清晰2厘米。讨论:瘢痕性子宫内膜异位症是一种非常罕见的疾病,据报道其发病率为0.03-0.45%。瘢痕性子宫内膜异位症的临床诊断对于瘢痕部位慢性疼痛的患者非常重要,但常常被忽视,并可能导致患者长期发病。随着组织病理学的证实,证明医源性植入理论是绝对必要的,这是公认的。结论:瘢痕性子宫内膜异位症的临床诊断取决于临床表现和既往产科手术史,切除边缘良好的病变是预防患者因疼痛和复发手术引起的慢性疾病的首选治疗方法。
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引用次数: 0
Preauricular Incision Approach as a Management of Zygomaticomaxillary Complex Fracture Reduction: A Case Report 耳前切口入路治疗颧颌复合体骨折1例报告
Pub Date : 2023-01-23 DOI: 10.32553/ijmbs.v7i1.2649
Ickman Setoaji Wibowo, S. Adiantoro, Eka Marwansyah, D. Maifara
Introduction: A zygomatico maxillary complex fracture is a facial bone fracture that commonly occurs as a centrally and laterally protruding zygomatic area. The effective surgical approach and exact reduction of the displaced fracture is the most important task in the treatment of a zygomatic fracture, from the aesthetic point of view. Determination of surgical approach and the fixation point of zygomatic arch fracture is one of the most challenging procedure. The purpose of this case report is to find out that the preauricular incison approach is one of the effective methods for reduction of zygomaticomaxillary complex fracture.Case Report: A 53 years old male patient presented with right zygomatico maxillary complex fractures. Diagnosis of right side tetrapod zygomatico maxillary complex fracture deformity was done by clinical examination and confirmed by computed tomography which included 3-D reconstruction view. The authors performed 4-point fixation using the preauricular approach to counter the disadvantages of the coronal approach. The results and usefulness of preauricular approach with 4-point fixation are reported in this study.Conclusion: Preauricular incision is an effective surgical approach for the reduction of zygomatic arch fracture. 4-point fixation using the easier-to-manipulate preauricular approach would be more useful than the conventional method that uses the coronal approach. Satisfactory reduction that showed exact correction was observed. In an outpatient follow-up, no complication such as nonunion or malunion was found, and facial symmetry was also shown. In addition, the preauricular scar was hardly observed.Keywords: zygomaticomaxillary complex fracture, preauricular incision, reduction, fixation
颧骨-上颌复合骨折是一种面部骨骨折,通常发生在中央和外侧突出的颧骨区。从美学的角度来看,有效的手术入路和移位骨折的精确复位是颧骨骨折治疗中最重要的任务。确定颧弓骨折的手术入路和固定点是最具挑战性的手术之一。本病例报告的目的是发现耳前切口入路是复位颧颌复合体骨折的有效方法之一。病例报告:一名53岁男性患者表现为右颧骨上颌复合体骨折。通过临床检查诊断右侧四足颧-上颌复合骨折畸形,并通过包括三维重建视图的计算机断层扫描证实。作者采用耳前入路进行4点固定,以克服冠状入路的缺点。本研究报告了耳前入路4点固定的结果和有效性。结论:耳前切口是颧骨弓骨折复位的有效手术入路。采用易于操作的耳前入路的4点固定比采用冠状入路的传统方法更有用。观察到令人满意的还原显示了精确的校正。在门诊随访中,未发现任何并发症,如不愈合或不愈合,面部也显示对称。耳前瘢痕几乎未见。关键词:颧腋复合体骨折,耳前切口,复位,固定
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引用次数: 0
Dermatophytosis- its impact on quality of life and financial burden 皮肤真菌病-它对生活质量和经济负担的影响
Pub Date : 2023-01-16 DOI: 10.32553/ijmbs.v7i1.2640
Reyan Abdul Jamil, K. Saxena, Venkatarao Koti, Swosti Mohanty
Background: Dermatophytosis is superficial skin infection caused by group of filamentous fungi called dermatophytes that affect the keratinized tissue. Almost every fifth person in the world is affected by it. It causes huge impact on the quality of life and is a cause of financial burden on the patients.Methods: The impact on the quality of life and the financial burden in patients diagnosed with dermatophytosis was assessed using DLQI questionnaire and financial burden questionnaire. The results were calculated using appropriate statistical tests.Results: Mean DLQI Score±SD (Range) was 14.48±5.18 (3-23). Mean financial burden and financial worry scores were 3.79±1.82 (out of 7) and 3.29±1.10 (out of 5) respectively. Quality of life of all the patients was affected, majority of the patients had Very large to Extremely large effect (72.5%), Small effect was observed in only 6.7% and Moderate effect in 20.8% patients.Conclusions: The findings of the study showed that quality of life was highly impaired in the patients with dermatophytosis and it also showed a significant association with financial burden.Key words: Dermatophytosis, quality of life, financial burden, financial worry, DLQI , tineaConclusion: Iron deficiency anemia is more frequent among children with febrile seizures than with febrile illness alone.
背景:皮肤真菌病是由一组被称为皮肤真菌的丝状真菌引起的浅表皮肤感染,它们影响角质化组织。世界上几乎有五分之一的人受其影响。它对患者的生活质量造成了巨大的影响,并给患者带来了经济负担。方法:采用DLQI问卷和经济负担问卷对确诊为皮肤真菌病患者的生活质量和经济负担的影响进行评估。使用适当的统计检验计算结果。结果:DLQI评分平均值±SD(范围)为14.48±5.18(3-23)。平均经济负担和经济忧虑得分分别为3.79±1.82(总分7分)和3.29±1.10(总分5分)。所有患者的生活质量均受到影响,大多数患者的影响为非常大至极大(72.5%),仅6.7%的患者观察到小影响,20.8%的患者观察到中度影响。结论:本研究结果表明,皮肤真菌病患者的生活质量严重受损,并且与经济负担有显著相关性。关键词:皮肤真菌病,生活质量,经济负担,经济忧虑,DLQI,时间结论:缺铁性贫血在热性惊厥患儿中发生率高于单纯热性疾病患儿。
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引用次数: 0
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International Journal of Medical and Biomedical Studies
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