International Journal of Obesity最新文献_第9页

The evolution of the understanding of obesity over the last 100 years 过去 100 年对肥胖症认识的演变。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-11-07 DOI: 10.1038/s41366-024-01668-3

Javier Gómez-Ambrosi, Victoria Catalán, Gema Frühbeck

The definition of obesity has evolved significantly over the last century, from a simplistic view of excessive eating and laziness to a complex, multifactorial disease with profound health and societal implications. As science progresses, it is essential that we keep improving our knowledge about obesity, taking into consideration, factors like genetics, metabolism, body composition, and the social determinants of health. This article explores how our understanding of this condition has been shaped over the last 100 years considering historical and scientific factors. The history and usefulness of the body mass index (BMI), the development of other anthropometric markers and the evolution in the incorporation of body composition into clinical practice, among other aspects related to the definition of obesity, are discussed. The challenges posed by obesity can be better addressed and more effective strategies for prevention and treatment can be developed adopting a more personalized and holistic approach. Obesity is not only a matter of individual responsibility but a multifaceted public health problem that requires a multidisciplinary and inclusive strategy to address its complexities.

在过去的一个世纪里，肥胖症的定义发生了重大变化，从简单地认为饮食过量和懒惰，发展成为一种复杂的、多因素的疾病，对健康和社会产生了深远的影响。随着科学的进步，我们必须不断提高对肥胖症的认识，同时考虑到遗传、新陈代谢、身体组成和健康的社会决定因素等因素。本文将探讨在过去的 100 年中，我们是如何在考虑历史和科学因素的基础上形成对肥胖症的认识的。文章讨论了体重指数（BMI）的历史和用途、其他人体测量指标的发展、将身体成分纳入临床实践的演变，以及与肥胖定义相关的其他方面。通过采用更加个性化和全面的方法，可以更好地应对肥胖带来的挑战，并制定更有效的预防和治疗策略。肥胖不仅是个人责任问题，也是一个多方面的公共卫生问题，需要采取多学科和包容性战略来解决其复杂性。

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引用次数: 0

Assessing the evidence for health benefits of low-level weight loss: a systematic review 评估低水平减肥对健康益处的证据：系统综述。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-11-01 DOI: 10.1038/s41366-024-01664-7

Disha Dhar, Jessica Packer, Semina Michalopoulou, Joana Cruz, Claire Stansfield, Russell M. Viner, Oliver T. Mytton, Simon J. Russell

Individuals with excess weight are at a higher risk for various physical and mental health conditions. Interventions targeting weight loss can improve health, with modest weight loss of five to ten percent of body weight often considered clinically meaningful for enhancing health outcomes. However, the benefits of achieving low-level weight loss ( < 5% body weight) are poorly understood. We aimed to systematically review relevant literature and synthesise the evidence that assessed the potential health benefits of losing less than five percent body weight. We searched seven academic databases and included studies in any language, from any country, with no time constraints. We included any intervention studies that assessed the impact of less than five percent weight loss on any measured physical or mental health markers or indices. 70 studies from 68 articles were included, with study participants ranging from 14 to 10,742. In total, 137 health markers were assessed, categorised into metabolic markers (n = 42), cardiovascular markers (n = 32), anthropometric measures (n = 19), quality of life indices (n = 10), inflammatory biomarkers (n = 10), renal and hepatic markers (n = 9), psychosocial and behavioural measures (n = 8), pulmonary function (n = 3), total mortality (n = 2), ovulatory function (n = 1), and muscle strength (n = 1). Overall, 60% of studies reported improvements, 37% found no change or mixed results, and 3% observed a worsening of health markers or indices. Based on the available data, 87% of participants (n = 15,839) in the studies reported improvements in health markers or indices as a result of low-level weight loss. Our findings suggest that low-level weight loss can lead to various health benefits and challenges the conventional threshold for effective weight loss. Preregistration The review protocol was pre-registered with PROSPERO (CRD42023406342)

体重超标的人罹患各种身心健康疾病的风险较高。以减轻体重为目标的干预措施可以改善健康状况，适度减轻 5%至 10%的体重通常被认为对改善健康状况具有临床意义。然而，实现低水平体重减轻的益处（例如

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引用次数: 0

The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium. 超重、肥胖和长期肥胖与 SARS-CoV-2 感染的关系：荷兰队列联合会 9 个人群队列的荟萃分析。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-31 DOI: 10.1038/s41366-024-01660-x

Bette Loef, Jolanda M A Boer, Marian Beekman, Sophie L Campman, Emiel O Hoogendijk, Floris Huider, Demi M E Pagen, Marije J Splinter, Jeroen H P M van der Velde, Dorret I Boomsma, Pieter C Dagnelie, Jenny van Dongen, Eco J C de Geus, Martijn Huisman, M Arfan Ikram, Annemarie Koster, Silvan Licher, Jochen O Mierau, Renée de Mutsert, H Susan J Picavet, Frits R Rosendaal, Miranda T Schram, P Eline Slagboom, Evie van der Spoel, Karien Stronks, W M Monique Verschuren, Saskia W van den Berg

Background: Obesity may affect an individual's immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.

Methods: We analyzed data from nine prospective population-based cohorts of the Netherlands Cohorts Consortium, with a total of 99,570 participants, following a standardized procedure. Body mass index (BMI) and waist circumference (WC) were assessed two times before the pandemic, with approximately 5 years between measurements. SARS-CoV-2 infection was defined by self-report as a positive PCR or rapid-antigen test or as COVID-19 ascertained by a physician between March 2020 and January 2023. For three cohorts, information on SARS-CoV-2 infection by serology was available. Results were pooled using random-effects meta-analyses and adjusted for age, sex, educational level, and number of SARS-CoV-2 infection measurements.

Results: Individuals with overweight (25 ≤ BMI < 30 kg/m²) (odds ratio (OR) = 1.08, 95%-confidence interval (CI) 1.04-1.13) or obesity (BMI ≥ 30 kg/m²) (OR = 1.43, 95%-CI 1.18-1.75) were more likely to report SARS-CoV-2 infection than individuals with a healthy body weight. We observed comparable ORs for abdominal overweight (men: 94 cm≤WC < 102 cm, women: 80 cm≤WC < 88 cm) (OR = 1.09, 95%-CI 1.04-1.14, I² = 0%) and abdominal obesity (men: WC ≥ 102 cm, women: WC ≥ 88 cm) (OR = 1.24, 95%-CI 0.999-1.55, I² = 57%). Individuals with obesity long before the pandemic, but with a healthy body weight or overweight just before the pandemic, were not at increased risk.

Conclusion: Overweight and obesity were associated with increased risk of SARS-CoV-2 infection with stronger associations for obesity. Individuals with a healthier weight prior to the pandemic but previous obesity did not have an increased risk of SARS-CoV-2, suggesting that weight loss in those with obesity reduces infection risk. These results underline the importance of obesity prevention and weight management for public health.

背景：肥胖可能会影响个人的免疫反应和随后的感染风险，如感染 SARS-CoV-2。目前尚不清楚超重和长期肥胖是否也构成风险因素。我们研究了超重和肥胖的程度和持续时间与 SARS-CoV-2 感染之间的关系：我们按照标准程序分析了荷兰队列联合会的九个前瞻性人群队列中的数据，共有 99,570 人参加。体重指数（BMI）和腰围（WC）在疫情爆发前进行了两次评估，两次评估之间相隔约 5 年。在 2020 年 3 月至 2023 年 1 月期间，SARS-CoV-2 感染的自我报告定义为 PCR 或快速抗原检测呈阳性，或由医生确认为 COVID-19 感染。有三个队列通过血清学获得了 SARS-CoV-2 感染信息。采用随机效应荟萃分析对结果进行汇总，并根据年龄、性别、教育程度和 SARS-CoV-2 感染测量次数进行调整：结果：与体重健康的人相比，超重（25 ≤ BMI 2）（比值比 (OR) = 1.08，95% 置信区间 (CI) 1.04-1.13）或肥胖（BMI ≥ 30 kg/m2）（比值比 = 1.43，95% 置信区间 (CI) 1.18-1.75）的人更有可能报告感染了 SARS-CoV-2。我们观察到腹部超重（男性：94 厘米≤WC 2 = 0%）和腹部肥胖（男性：WC ≥ 102 厘米，女性：WC ≥ 88 厘米）的 OR 值相当（OR = 1.24，95%-CI 0.999-1.55，I2 = 57%）。早在大流行前就有肥胖症，但在大流行前体重健康或超重的人的风险并没有增加：结论：超重和肥胖与感染 SARS-CoV-2 的风险增加有关，肥胖的相关性更大。大流行前体重较健康但曾有肥胖症的人感染 SARS-CoV-2 的风险并没有增加，这表明肥胖症患者减轻体重可降低感染风险。这些结果凸显了预防肥胖和控制体重对公共卫生的重要性。

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引用次数: 0

Shaping childhood obesity: behavioral and environmental risk factors associated with body mass index trajectories between 2 and 9 years in Samoan children 塑造儿童肥胖症：与萨摩亚儿童 2 至 9 岁体重指数轨迹相关的行为和环境风险因素。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-29 DOI: 10.1038/s41366-024-01665-6

Courtney C. Choy, William Johnson, Take Naseri, Vaimoana Filipo, Maria Siulepa Arorae, Faatali Tafunaina, Folla Unasa, Kima Savusa, Muagututia S. Reupena, Joseph M. Braun, Rachel L. Duckham, Christina Soti-Ulberg, Stephen T. McGarvey, Nicola L. Hawley

Pacific children are at high obesity risk, yet the behavioral and environmental factors that contribute to obesity development in this setting remain poorly understood. We assessed associations between childhood risk factors for obesity with body mass index (BMI) trajectories between ages 2–9 years in Samoa. In a prospective cohort of 485 children from ‘Upolu, we measured weight and height at ages 2–4 (2015), 3.5–8 (2017–18), and 5.5–11 years (2019–20). Modern dietary pattern adherence was assessed using factor analysis of primary caregiver-reported food frequency questionnaire data. Physical activity was estimated with the Netherlands Physical Activity Questionnaire. Socioeconomic resources were assessed using an 18-item household asset score. Urbanicity was based on village residence. Associations of these risk factors with predicted weight, height, and BMI (at 1-year intervals and velocity) were assessed using multilevel cubic spline regressions. Females had greater adjusted weight velocity with high modern dietary pattern adherence compared to low (p-value for interaction with age spline term 1 = 0.028 and age spline term 2 = 0.007). Starting at age 3 years, children with higher physical activity had higher BMI, but this association was not meaningful up to age 9 (all p-value > 0.05). Males with very high compared to low household assets had higher BMI from age 2 to 4 years (95% CI: 0.26–1.53 kg/m2, p = 0.006) and greater BMI velocity (p-value for interaction with age spline term 2 = 0.001). Males in the urban region had the greatest BMI gain after age 5 compared to the rural region (p-value for interaction with age spline term 2 = 0.014). High, centile-crossing BMI trajectories suggest that obesity prevention and intervention are needed among Samoan children before age 9 years. Positive associations between high modern dietary pattern adherence, greater asset ownership, and urbanization offer initial insights into who, and which behavioral risk factors, should be prioritized in implementing public health solutions.

背景/目的：太平洋地区的儿童肥胖风险很高，但在这种环境下，导致肥胖发展的行为和环境因素仍然鲜为人知。我们评估了萨摩亚 2-9 岁儿童肥胖风险因素与体重指数（BMI）轨迹之间的关系：在来自'Upolu的485名儿童的前瞻性队列中，我们测量了2-4岁（2015年）、3.5-8岁（2017-18年）和5.5-11岁（2019-20年）儿童的体重和身高。通过对主要照顾者报告的食物频率问卷数据进行因子分析，评估了现代饮食模式的坚持情况。体力活动通过荷兰体力活动问卷进行估算。社会经济资源采用 18 项家庭资产评分进行评估。城市化程度基于村庄居住地。这些风险因素与预测体重、身高和体重指数（1年间隔和速度）的关系采用多层次立方样条回归进行评估：结果：与较低的现代膳食模式坚持率相比，较高的现代膳食模式坚持率下女性的调整后体重速度更大（与年龄曲线项 1 的交互作用 p 值 = 0.028，与年龄曲线项 2 的交互作用 p 值 = 0.007）。从 3 岁开始，体力活动较多的儿童的体重指数较高，但这种关联在 9 岁之前没有意义（所有 p 值均大于 0.05）。与家庭资产少的男性相比，家庭资产多的男性在 2 至 4 岁时的体重指数较高（95% CI：0.26-1.53 kg/m2，p = 0.006），体重指数速度较快（与年龄的交互作用项 2 的 p 值 = 0.001）。与农村地区相比，城市地区的男性在 5 岁后的 BMI 增幅最大（与年龄的交互作用项 2 的 p 值 = 0.014）：结论：BMI 指数的高位交叉轨迹表明，需要对 9 岁前的萨摩亚儿童进行肥胖预防和干预。高现代饮食模式坚持率、更多资产所有权和城市化之间的正相关关系，为在实施公共卫生解决方案时应优先考虑哪些人和哪些行为风险因素提供了初步见解。

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引用次数: 0

U.S. weight trends: a longitudinal analysis of an NIH-partnered dataset 美国体重趋势：对美国国立卫生研究院合作数据集的纵向分析。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-29 DOI: 10.1038/s41366-024-01661-w

Dawda Jawara, Craig M. Krebsbach, Manasa Venkatesh, Jacqueline A. Murtha, Bret M. Hanlon, Kate V. Lauer, Lily N. Stalter, Luke M. Funk

Obesity is a major public health challenge in the U.S. Existing datasets utilized for calculating obesity prevalence, such as the National Health and Nutrition Examination Survey (NHANES) and Behavioral Risk Factor Surveillance System (BRFSS), have limitations. Our objective was to analyze weight trends in the U.S. using a nationally representative dataset that incorporates longitudinal electronic health record data. Using the National Institutes of Health All of Us Research Program (AoU) dataset, we identified patients aged 18–70 years old who had at least two height and weight measurements within a 5-year period from 2008 to 2021. Baseline and most recent BMI values were used to calculate total body weight (%TBW) changes. %TBW change predictors were determined using multivariable linear regression. We included 30,862 patients (mean age 48.9 [ ± 12.6] years; 60.5% female). At the 5-year follow-up, the prevalences of obesity and severe obesity were 37.4% and 20.7%, respectively. The frequency of patients with normal weight or overweight BMI who gained ≥5% TBW at follow-up was 37.8% and 33.1%, respectively. Nearly 24% of the cohort lost ≥ 5% TBW, and 6.5% with severe obesity lost weight to achieve a BMI < 30 kg/m2. In adjusted analyses, male sex (−1.10%, 95% CI [−1.36, −0.85]), non-Hispanic Asian race/ethnicity (−1.69% [−2.44, −0.94]), and type 2 diabetes (−1.58% [−1.95, −1.22]) were associated with weight loss, while obstructive sleep apnea (1.80% [1.40, 2.19]) was associated with weight gain. This evaluation of an NIH-partnered dataset suggests that patients are continuing to gain weight in the U.S. AoU represents a unique tool for obesity prediction, prevention, and treatment given its longitudinal nature and unique behavioral and genetic data.

背景：用于计算肥胖患病率的现有数据集，如美国国家健康与营养调查（NHANES）和行为风险因素监测系统（BRFSS），都存在局限性。我们的目标是利用包含纵向电子健康记录数据的全国代表性数据集分析美国的体重趋势：我们利用美国国立卫生研究院的 "我们所有人研究计划"（AoU）数据集，确定了从 2008 年到 2021 年的 5 年间至少测量过两次身高和体重的 18-70 岁患者。基线和最近的 BMI 值用于计算总体重 (%TBW) 变化。采用多变量线性回归法确定总体重变化率的预测因素：我们纳入了 30,862 名患者（平均年龄 48.9 [ ± 12.6] 岁；60.5% 为女性）。在 5 年的随访中，肥胖和严重肥胖的患病率分别为 37.4% 和 20.7%。体重指数正常或超重的患者中，随访时总热量增加≥5% 的比例分别为 37.8% 和 33.1%。近 24% 的患者体重减轻≥5%，6.5% 的重度肥胖患者体重减轻至 BMI 2。在调整分析中，男性（-1.10%，95% CI [-1.36，-0.85]）、非西班牙裔亚洲人种/民族（-1.69% [-2.44，-0.94]）和 2 型糖尿病（-1.58% [-1.95，-1.22]）与体重减轻有关，而阻塞性睡眠呼吸暂停（1.80% [1.40，2.19]）与体重增加有关：对美国国立卫生研究院（NIH）合作的数据集进行的评估表明，美国患者的体重仍在增加。AoU 是预测、预防和治疗肥胖症的独特工具，因为它具有纵向性质和独特的行为与遗传数据。

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引用次数: 0

Association between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysis. 体形指数与动脉僵化之间的关系：EVasCu 研究结果和荟萃分析。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-28 DOI: 10.1038/s41366-024-01663-8

Alicia Saz-Lara, Iván Cavero-Redondo, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Carlos Berlanga-Macías, María Medrano, Rosa María Fuentes Chacón, Carlos Pascual-Morena

Objective: The aim of this study was to analyse the association between body shape index (ABSI) and arterial stiffness in healthy subjects using data from the EVasCu study. In addition, a meta-analysis was performed to compare the association between ABSI and central, peripheral and systemic arterial stiffness in the general population.

Methods: The EVasCu study included 390 healthy subjects. ABSI was calculated from waist circumference, body mass index and height, and arterial stiffness was assessed with aortic pulse wave velocity (a-PWv) and cardio-ankle vascular index (CAVI). A meta-analysis of previous studies, including data from the EVasCu study, was performed to obtain pooled estimates of correlation coefficients (r) and their respective 95% confidence intervals (95% CIs) for the association between ABSI and central, peripheral and systemic arterial stiffness. In addition, pooled OR estimates and their 95% CIs were calculated.

Results: In the EVasCu study, the correlation coefficient estimate was 0.458 (p < 0.01) for the association of a-PWv and ABSI and 0.408 (p < 0.01) for the association of CAVI and ABSI. In the meta-analysis, the pooled correlation coefficient estimate was 0.22 (95% CIs: 0.16, 0.28) for central arterial stiffness and ABSI, 0.21 (95% CIs: 0.14, 0.28) for peripheral arterial stiffness and ABSI, and 0.28 (95% CI: 0.21, 0.3) for systemic arterial stiffness and ABSI. When pooled ORs were calculated, the pooled OR estimate was 2.12 (95% CIs: 1.68, 2.56) for central arterial stiffness and ABSI, 2.21 (95% CIs: 1.81, 2.60) for peripheral arterial stiffness and ABSI, and 2.99 (95% CIs: 2.14, 3.85) for systemic arterial stiffness and ABSI.

Conclusion: Based on both the results obtained in the EVasCu study and the meta-analysis, there is a positive association between ABSI and arterial stiffness, both in healthy subjects and in participants with comorbidities. For each unit of cm/kg/m²/m increase in ABSI, the risk of arterial stiffness increased by 112% for central arterial stiffness, 121% for peripheral arterial stiffness, and 199% for systemic arterial stiffness. However, further research is needed in this field of knowledge.

研究目的本研究旨在利用 EVasCu 研究的数据分析健康受试者的体形指数（ABSI）与动脉僵化之间的关系。此外，还进行了一项荟萃分析，以比较 ABSI 与普通人群的中心、外周和全身动脉僵化之间的关系：EVasCu研究包括390名健康受试者。ABSI根据腰围、体重指数和身高计算，动脉僵化则通过主动脉脉搏波速度（a-PWv）和心踝血管指数（CAVI）评估。对包括 EVasCu 研究数据在内的以往研究进行了荟萃分析，以获得 ABSI 与中心、外周和全身动脉僵化之间相关系数 (r) 的集合估计值及其各自的 95% 置信区间 (95%CI)。此外，还计算了集合 OR 估计值及其 95% CI：结果：在 EVasCu 研究中，相关系数估计值为 0.458（p 结论：在 EVasCu 研究中，相关系数估计值为 0.458：根据 EVasCu 研究和荟萃分析的结果，无论是健康受试者还是有合并症的受试者，ABSI 与动脉僵化之间都存在正相关。ABSI 每增加一个单位 cm/kg/m²/m，中心动脉僵化的风险增加 112%，外周动脉僵化的风险增加 121%，全身动脉僵化的风险增加 199%。然而，在这一知识领域还需要进一步的研究。

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引用次数: 0

Dietary patterns among European children and their association with adiposity-related outcomes: a multi-country study 欧洲儿童的饮食模式及其与脂肪相关结果的关系：一项多国研究。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-27 DOI: 10.1038/s41366-024-01657-6

Sarah Warkentin, Nikos Stratakis, Lorenzo Fabbri, John Wright, Tiffany C. Yang, Maria Bryant, Barbara Heude, Remy Slama, Parisa Montazeri, Marina Vafeiadi, Regina Grazuleviciene, Anne Lise Brantsæter, Martine Vrijheid

Children’s diets in school-age are inherently unhealthy, with few meeting dietary recommendations. Yet, little is known about similarities and differences on dietary patterns across countries and their association with obesity. We aimed to derive dietary patterns in childhood and explore their association with adiposity-related outcomes in childhood and adolescence. This study included data from six European countries (Spain, France, UK, Greece, Lithuania and Norway) during childhood (n = 1597) and adolescence (n = 803). Using a food frequency questionnaire, we derived data-driven dietary patterns through exploratory factor analyses and calculated the Mediterranean KIDMED index. We assessed body mass index z-score (zBMI), fat mass proportion and waist-to-height ratio at both visits. Associations were estimated using generalized linear regressions, adjusted for key-confounders. “Meat”, “Dairy”, “Western”, “Healthy” and “Sweets and fats” dietary patterns were derived. Norwegian children showed better diet quality, with higher consumption of fruits and vegetables, and highest “Healthy pattern” adherence, and Lithuanian children, the worst, with higher sweets consumption, and highest “Western pattern” adherence. Children with lower intake of healthy foods (vegetables, fruits, fish) tended to have higher adiposity, e.g., children with average or low “Healthy pattern” adherence (vs. high) had higher fat mass proportion in childhood (average: β (95% CI) 1.44 (0.48; 2.39), low: 1.10 (0.09; 2.12)). Low adherence to a “Healthy pattern” (vs. high) was associated with increased adolescent zBMI, and child and adolescent waist-to-height ratio. Low “Dairy pattern” adherence (vs. high), was associated with lower zBMI and fat mass in childhood, but not in adolescence. No significant associations were seen with the KIDMED index. Many European children have poor diets and a low adherence to a healthy diet pattern may be of concern for adiposity-related outcomes. Assessment of children’s dietary patterns can help tailor dietary advice and provide support for families aiming to prevent future excess weight gain.

背景/目的：学龄儿童的饮食本身就不健康，很少有儿童的饮食符合膳食建议。然而，人们对各国膳食模式的异同及其与肥胖的关系知之甚少。我们的目的是得出儿童时期的饮食模式，并探讨其与儿童和青少年时期脂肪相关结果的联系：这项研究包括六个欧洲国家（西班牙、法国、英国、希腊、立陶宛和挪威）在儿童期（n = 1597）和青少年期（n = 803）的数据。我们使用食物频率问卷，通过探索性因素分析得出数据驱动的饮食模式，并计算出地中海 KIDMED 指数。我们在两次访问中都评估了体重指数 z 值（zBMI）、脂肪质量比例和腰围与身高的比率。我们使用广义线性回归对相关性进行了估计，并对关键因素进行了调整：结果：得出了 "肉类"、"乳制品"、"西式"、"健康 "和 "甜食与脂肪 "饮食模式。挪威儿童的饮食质量较好，水果和蔬菜摄入量较高，"健康饮食模式 "坚持率最高；立陶宛儿童的饮食质量最差，甜食摄入量较高，"西式饮食模式 "坚持率最高。摄入健康食品（蔬菜、水果、鱼类）较少的儿童往往脂肪含量较高，例如，"健康模式 "依从性一般或较低（与较高相比）的儿童在童年时脂肪质量比例较高（平均：β（95% CI）1.44（0.48；2.39），较低：1.10（0.09；2.12））。健康模式 "坚持率低（与坚持率高相比）与青少年 zBMI 以及儿童和青少年腰围与身高比率增加有关。乳制品模式 "坚持率低（与坚持率高相比）与儿童时期 zBMI 和脂肪量较低有关，但与青少年时期无关。与 KIDMED 指数没有明显关联：结论：许多欧洲儿童的饮食习惯不良，对健康饮食模式的依从性较低可能会导致与脂肪相关的结果。对儿童饮食模式的评估有助于为家庭量身定制饮食建议并提供支持，以防止未来体重增加过多。

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引用次数: 0

Incidence and risk factors of post-metabolic and bariatric surgery hypoglycemia: a systematic review 代谢和减肥手术后低血糖的发生率和风险因素：系统综述。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-24 DOI: 10.1038/s41366-024-01651-y

Huaijun Zheng, Lize Sun, Linjie Wang, Yuxing Zhao, Fengying Gong, Huijuan Zhu

This study aimed to systematically review the existing literature to summarize the incidence and risk factors of post-metabolic and bariatric surgery hypoglycemia (MBSH). We searched PubMed, Medline, Embase, and the Cochrane Library databases for the studies published from inception to August 2023. Randomized controlled trials and analytical studies that investigated the incidence or risk factors of MBSH after different surgery techniques (including Roux-en-Y gastric bypass, sleeve gastrectomy, gastric banding, duodenal switch, omega-loop gastric bypass, and vertical banded gastroplasty) were involved. The incidence and risk factors of MBSH were extracted and described separately based on different diagnostic criteria and then summarized the risk factors and their statistical findings collectively. Twenty-nine studies were reviewed with follow-up ranging from 1 to 22 years. The incidence of MBSH ranged significantly across different diagnostic methods: 2.6–66.4% (self-report), 6.6–61.8% (oral glucose tolerance test), 29.4–78.6% (mixed-meal tolerance test), and 50–75% (continuous glucose monitoring). Patients with a mean age of 49.8 years and 89.0% of them were women with a better glycemic control who undergo RYGB and achieve 86.5% of estimated weight loss from surgery should be particularly vigilant about the possibility of developing MBSH. Distinct biomarkers such as IGF-1 (OR 1.06), fasting glicentin (AUC 0.81), HbA1c (AUC 0.76), and absolute weight reduction (AUC 0.72), greater fluctuations in glucose (OR 1.98) are valuable in promptly detecting MBSH. Specifically, patients with prior cholecystectomy or antidepressant therapy should be particularly cautious. The review highlights higher MBSH risk in younger women with significant weight loss after RYGB, and those with prior cholecystectomy or antidepressant use. Systematic summarization of MBSH criteria allowed us to identify the predictors for MBSH, which can aid in early diagnosis and treatment, reducing the need for prolonged monitoring.

研究目的本研究旨在系统回顾现有文献，总结代谢和减肥术后低血糖（MBSH）的发生率和风险因素：我们检索了 PubMed、Medline、Embase 和 Cochrane 图书馆数据库中从开始到 2023 年 8 月发表的研究。方法：我们检索了 PubMedline、Embline 和 Cochrane 图书馆数据库中从 2023 年 8 月开始发表的研究，其中包括调查不同手术技术（包括 Roux-en-Y 胃旁路术、袖状胃切除术、胃束带术、十二指肠转换术、Ω-环胃旁路术和垂直束带胃成形术）后 MBSH 发生率或风险因素的随机对照试验和分析研究。根据不同的诊断标准，分别提取并描述了MBSH的发病率和风险因素，然后对风险因素及其统计结果进行了汇总：结果：共回顾了 29 项研究，随访时间从 1 年到 22 年不等。不同诊断方法的 MBSH 发生率差异显著：2.6%-66.4%（自我报告）、6.6%-61.8%（口服葡萄糖耐量试验）、29.4%-78.6%（混合餐耐量试验）和 50%-75%（连续葡萄糖监测）。平均年龄为 49.8 岁的患者中，89.0% 为血糖控制较好的女性，她们接受了 RYGB 并通过手术实现了 86.5% 的预计体重减轻，因此应特别警惕发生 MBSH 的可能性。IGF-1（OR 1.06）、空腹格列酮肽（AUC 0.81）、HbA1c（AUC 0.76）、体重绝对值减少（AUC 0.72）、血糖波动较大（OR 1.98）等不同的生物标志物对于及时发现 MBSH 具有重要价值。特别是，曾接受胆囊切除术或抗抑郁治疗的患者应特别谨慎：综述强调，RYGB术后体重明显减轻的年轻女性、曾接受胆囊切除术或服用抗抑郁药物的女性发生MBSH的风险较高。通过对 MBSH 标准的系统总结，我们确定了 MBSH 的预测因素，这有助于早期诊断和治疗，减少长期监测的需要。

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引用次数: 0

Drugs used in psychiatry causing an increase in body weight in children-a review. 导致儿童体重增加的精神科用药--综述。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-24 DOI: 10.1038/s41366-024-01662-9

Karolina Kuźbicka, Iga Pawłowska, Ivan Kocić

Body weight gain is a prevalent adverse effect observed in psychiatric medication therapy. With the notable increase in mental health diagnoses among children and adolescents over the last decade, exacerbated by the COVID-19 pandemic, the use of medications associated with weight gain poses an additional risk for obesity development. This study aimed to identify psychiatric drugs that may induce weight gain in children as a side effect. Twenty-nine publications were included in this systematic review, investigating the effects of nineteen different drugs on children's weight. The majority of these drugs belonged to atypical antipsychotics and anticonvulsants. Nearly all included articles reported that the examined substances resulted in weight gain in children. As childhood obesity has become a significant problem with various metabolic, psychological and social consequences, it is crucial to carefully consider therapy options. In addition to evaluating effectiveness, it is important to also assess the potential for weight gain. Clinicians and nutrition specialists should individually evaluate patients' nutritional needs, evaluate obesity risk, and provide appropriate dietary guidance to minimalize the risk of weight gain.

体重增加是精神科药物治疗中普遍存在的不良反应。在过去十年中，儿童和青少年的精神健康诊断显著增加，COVID-19 的流行更加剧了这一趋势，因此使用与体重增加相关的药物会增加肥胖的风险。本研究旨在找出可能导致儿童体重增加的精神科药物副作用。本系统综述共收录了 29 篇文献，调查了 19 种不同药物对儿童体重的影响。这些药物大多属于非典型抗精神病药物和抗惊厥药物。几乎所有收录的文章都报告说，所研究的药物会导致儿童体重增加。由于儿童肥胖症已成为一个严重问题，会造成各种代谢、心理和社会后果，因此仔细考虑治疗方案至关重要。除了评估有效性外，还必须评估体重增加的可能性。临床医生和营养专家应单独评估患者的营养需求，评估肥胖风险，并提供适当的饮食指导，将体重增加的风险降至最低。

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引用次数: 0

What internet- and mobile-based interventions are currently available for adults with overweight or obesity experiencing symptoms of depression? A systematic review 对于有抑郁症状的超重或肥胖成年人，目前有哪些基于互联网和移动设备的干预措施？系统综述。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity

Pub Date : 2024-10-21 DOI: 10.1038/s41366-024-01654-9

Katja Schladitz, Alina Seibel, Melanie Luppa, Steffi G. Riedel-Heller, Margrit Löbner

Given the high prevalence of overweight and obesity and high comorbidity of depressive symptoms, there is a need for low-threshold, accessible care approaches for people with overweight/obesity aimed at improving mental health. Internet and mobile-based interventions (IMI) represent an innovative complementary treatment option. This review systematically searches for IMI aimed at improving mental health in people with overweight/obesity. We conducted a systematic literature search according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria in the databases MEDLINE, Cochrane Library, PsycINFO, Web of Science and Google Scholar. Randomized controlled trials (RCTs) of IMI for adults with overweight/obesity and comorbid depressive symptoms aiming at improving mental health were screened and extracted. Study quality was assessed with RoB 2 (revised Cochrane Risk of Bias tool in RCTs). After excluding duplicates, n = 790 results were included in title and abstract screening. After full-text-screening of n = 26 studies, n = 3 RCT studies were included. All interventions aimed to reduce both weight and depressive symptoms. In two RCTs, a significant reduction in both depressive symptoms and weight was achieved. One RCT indicated a significant reduction in depressive symptoms, but not in weight. Two intervention had a duration of 6 months and were guided by health carers, the third takes 3 months and can be used without professional guidance. There is evidence that IMI are effective in improving mental health for people with overweight/obesity and comorbid depressive symptoms. However, currently there are few interventions aiming at reducing depressive symptoms, all targeting English-speaking people. As IMI for depressive symptoms can be easily integrated in the somatic therapy of obesity as additional option and has high public health potential, target group-adapted and low-threshold accessible interventions in different languages should be developed and implemented for improving mental health in people with overweight/obesity. Prospero registration number: CRD42023361771.

鉴于超重和肥胖症的高发病率以及抑郁症状的高合并率，有必要为超重/肥胖症患者提供低门槛、无障碍的护理方法，以改善他们的心理健康。基于互联网和移动设备的干预（IMI）是一种创新的辅助治疗方法。本综述系统地检索了旨在改善超重/肥胖症患者心理健康的 IMI。我们根据 PRISMA（系统综述和元分析的首选报告项目）标准，在 MEDLINE、Cochrane Library、PsycINFO、Web of Science 和 Google Scholar 等数据库中进行了系统的文献检索。筛选并提取了针对超重/肥胖并伴有抑郁症状的成年人、旨在改善心理健康的 IMI 随机对照试验（RCT）。研究质量采用 RoB 2（修订版 Cochrane Risk of Bias RCTs 工具）进行评估。在排除重复研究后，共有 790 项研究结果被纳入标题和摘要筛选。在对 n = 26 项研究进行全文筛选后，纳入了 n = 3 项 RCT 研究。所有干预措施都旨在减轻体重和抑郁症状。在两项研究中，抑郁症状和体重均有显著减轻。一项研究表明，抑郁症状明显减轻，但体重没有减轻。两项干预持续时间为 6 个月，由医护人员指导；第三项干预持续时间为 3 个月，无需专业指导。有证据表明，对于超重/肥胖并伴有抑郁症状的人来说，综合心理干预能有效改善他们的心理健康。然而，目前旨在减轻抑郁症状的干预措施并不多，而且都是针对讲英语的人。由于治疗抑郁症状的 IMI 可作为附加选项轻松融入肥胖症的躯体治疗中，并且具有很高的公共卫生潜力，因此应开发和实施适合目标群体、低门槛、使用不同语言的干预措施，以改善超重/肥胖症患者的心理健康。Prospero 注册号：CRD42023361771。

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引用次数: 0