To address the decline in energy efficiency during the mid-to-late stages of the drying process in heat pump drying (HPD), this study introduces intermittent drying based on a closed-loop transcritical CO2 HPD system, and with lemon slices as the research object, experimentally investigates the impact of intermittent ratio in closed-loop heat pump intermittent drying on the wet-basis moisture content (Mt), drying rate, coefficient of performance of the system (COPsys), specific moisture extraction rate (SMER), specific energy consumption (SEC), mass of drying per unit volume per unit time (MDVT), rehydration ratio, brightness of dried material and vitamin C content. The findings suggest that when the intermittent ratio rises, the average drying rate, average SMER, SEC, MDVT, rehydration ratio, brightness of dried material and vitamin C content all increase, while the average COPsys remains essentially unchanged. The average drying rate, average SMER, SEC, MDVT, rehydration ratio, brightness of dried material and vitamin C content have maximum values at an optimal intermittent ratio of 4/6. Accordingly, a combined drying process of “continuous drying-intermittent drying-continuous drying” is proposed: when the Mt reaches 70 %, the drying mode should transition from continuous drying to intermittent drying; when the Mt reaches 40 %, the mode should shift back from intermittent drying to continuous drying. The findings provide important references for the industrial drying of lemon.