Pub Date : 2022-04-09DOI: 10.26452/ijrps.v13i2.129
Mahitha M, Mahendra Kumar K
Diabetes is the leading cause of adult blindness, end stage renal disease, coronary heart disease, stroke, foot ulcers and lower limb amputations. Serum uric acid levels independently predict the development of macro vascular and micro vascular complications. In this study we analyse the association of serum uric acid with the macro and micro vascular complications of diabetes. In this hospital based observational study, hundred diabetic patients were included; of which fifty had complications, the remaining fifty had no complications. Blood investigations including fasting and post prandial blood sugars, glycosylated haemoglobin, serum creatinine, micro albuminuria, lipid profile, serum uric acid were done in all patients. All the parameters were compared between the two groups. Males with complications had significant high uric acid than females with complications. HbA1c, total cholesterol levels, micro albuminuria, serum creatinine had a positive correlation with the serum uric acid. Uric acid levels were higher among patients with complications compared to patients without complications which was statistically significant (p =0.00001). Patients with nephropathy, retinopathy and coronary heart disease had elevation in serum uric acid levels which was statistically significant. Patients with complications had higher uric acid levels than patients without complications.
{"title":"A Study of Correlation of Serum Uric Acid Levels With Diabetic Complications","authors":"Mahitha M, Mahendra Kumar K","doi":"10.26452/ijrps.v13i2.129","DOIUrl":"https://doi.org/10.26452/ijrps.v13i2.129","url":null,"abstract":"Diabetes is the leading cause of adult blindness, end stage renal disease, coronary heart disease, stroke, foot ulcers and lower limb amputations. Serum uric acid levels independently predict the development of macro vascular and micro vascular complications. In this study we analyse the association of serum uric acid with the macro and micro vascular complications of diabetes. In this hospital based observational study, hundred diabetic patients were included; of which fifty had complications, the remaining fifty had no complications. Blood investigations including fasting and post prandial blood sugars, glycosylated haemoglobin, serum creatinine, micro albuminuria, lipid profile, serum uric acid were done in all patients. All the parameters were compared between the two groups. Males with complications had significant high uric acid than females with complications. HbA1c, total cholesterol levels, micro albuminuria, serum creatinine had a positive correlation with the serum uric acid. Uric acid levels were higher among patients with complications compared to patients without complications which was statistically significant (p =0.00001). Patients with nephropathy, retinopathy and coronary heart disease had elevation in serum uric acid levels which was statistically significant. Patients with complications had higher uric acid levels than patients without complications.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75658829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hussein I. H. Al-Azzawi, Zaid M. M. Almahdawi, Ayad H. Ibrahim, Wieeam A. Saleh
The current study included two aspects, one of which is histological and the other physiological. It included (75) blood samples from women with breast cancer, in addition to (15) blood samples for healthy women as control, in addition to collecting tissue biopsy from the mammary glands of some women whose blood samples were drawn Including them in advance. Those diagnosed with breast cancer and ages ranged between 38-68 years, where the study was conducted from 1 May 2019 to 2 October 2019. Gland tissue and the owner of those tumours swelling of the axillary lymph nodes. Another cancer that was found was papillary carcinoma, where epithelial hyperplasia appeared in the form of large papillae that filled the cavity of the gland. There is a large number of white blood cells and severe hematoma. Another type of gland cancer discovered is cribriform carcinoma, which is a rare case. Invasive cancer is the most dangerous, as it is observed in the glandular tissue with the presence of agglutination and crowding of tumour cells and tumour cysts. The study also showed haematological changes characterized by a highly significant concentration of Endothelin-1 (P< 0.01) in the blood of women with breast cancer group 5 and group 4, compared to the control group as a usual case. At the same time, there was a significant increase (P < 0.05) in the con- centration of Endothelin-1 in infected women in groups 3, 2 and 6 compared to the control group. The study showed a very significant decrease (P < 0.01) in the cholesterol concentration of women with breast cancer of group 5, and group 6 compared to the control group, while its level decreased significantly (P ≤ 0.05) in-group 4 compared to the control group.
{"title":"Histological and Physiological assessment of Endothelin-1 and Cholesterol in breast cancer of women","authors":"Hussein I. H. Al-Azzawi, Zaid M. M. Almahdawi, Ayad H. Ibrahim, Wieeam A. Saleh","doi":"10.26452/ijrps.v13i2.94","DOIUrl":"https://doi.org/10.26452/ijrps.v13i2.94","url":null,"abstract":"The current study included two aspects, one of which is histological and the other physiological. It included (75) blood samples from women with breast cancer, in addition to (15) blood samples for healthy women as control, in addition to collecting tissue biopsy from the mammary glands of some women whose blood samples were drawn Including them in advance. Those diagnosed with breast cancer and ages ranged between 38-68 years, where the study was conducted from 1 May 2019 to 2 October 2019. Gland tissue and the owner of those tumours swelling of the axillary lymph nodes. Another cancer that was found was papillary carcinoma, where epithelial hyperplasia appeared in the form of large papillae that filled the cavity of the gland. There is a large number of white blood cells and severe hematoma. Another type of gland cancer discovered is cribriform carcinoma, which is a rare case. Invasive cancer is the most dangerous, as it is observed in the glandular tissue with the presence of agglutination and crowding of tumour cells and tumour cysts. The study also showed haematological changes characterized by a highly significant concentration of Endothelin-1 (P< 0.01) in the blood of women with breast cancer group 5 and group 4, compared to the control group as a usual case. At the same time, there was a significant increase (P < 0.05) in the con- centration of Endothelin-1 in infected women in groups 3, 2 and 6 compared to the control group. The study showed a very significant decrease (P < 0.01) in the cholesterol concentration of women with breast cancer of group 5, and group 6 compared to the control group, while its level decreased significantly (P ≤ 0.05) in-group 4 compared to the control group.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78233004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension manifests in the eyes as retinopathy, choroidopathy and optic neuropathy of which retinopathy can be used as a predictor for systemic morbidities and mortalities. The objective of the study was to determine the prevalence of retinopathy in hypertensive patients and determine the correlation of retinopathy with parameters like age, sex, duration of hypertension, severity of hypertension and control of hypertension. This was a cross-sectional, retrospective study done in patients attending our hospital between January to March 2019 comprising of 200 patients. The grading of retinopathy was done using Keith-Wagner-Barker system. The presence of retinopathy was compared with parameters like age, sex and duration of hypertension. Statistical analysis was done using MS-Excel and Chi-square test. Among the 200 hypertensive patients (117 males, 83 females), 57 patients had retinopathy (28.5%) of which 35 were males and 22 were females. Among patients with retinopathy, 32 had Grade 1, 16 had Grade 2, 8 had Grade 3 and 1 had Grade 4 retinopathy. Based on the severity of hypertension, 8 out of 61 patients having mild hypertension, 25 out of 81 patients had moderate hypertension and 24 out of 58 patients having severe hypertension, had retinopathy. The prevalence of retinopathy was higher in patients with hypertension for 5 years or more (54.4%) than those with hypertension with less than 5 years (21.8%). Our study showed prevalence of hypertensive retinopathy to be 28.5%. Severity of hypertension and duration of hypertension > 5 years was found to have an association with hypertensive retinopathy.
{"title":"Prevalence of hypertensive retinopathy in hypertensive patients","authors":"Ifrath Nusaiba, Panimalar Veeramani","doi":"10.26452/ijrps.v13i2.91","DOIUrl":"https://doi.org/10.26452/ijrps.v13i2.91","url":null,"abstract":"Hypertension manifests in the eyes as retinopathy, choroidopathy and optic neuropathy of which retinopathy can be used as a predictor for systemic morbidities and mortalities. The objective of the study was to determine the prevalence of retinopathy in hypertensive patients and determine the correlation of retinopathy with parameters like age, sex, duration of hypertension, severity of hypertension and control of hypertension. This was a cross-sectional, retrospective study done in patients attending our hospital between January to March 2019 comprising of 200 patients. The grading of retinopathy was done using Keith-Wagner-Barker system. The presence of retinopathy was compared with parameters like age, sex and duration of hypertension. Statistical analysis was done using MS-Excel and Chi-square test. Among the 200 hypertensive patients (117 males, 83 females), 57 patients had retinopathy (28.5%) of which 35 were males and 22 were females. Among patients with retinopathy, 32 had Grade 1, 16 had Grade 2, 8 had Grade 3 and 1 had Grade 4 retinopathy. Based on the severity of hypertension, 8 out of 61 patients having mild hypertension, 25 out of 81 patients had moderate hypertension and 24 out of 58 patients having severe hypertension, had retinopathy. The prevalence of retinopathy was higher in patients with hypertension for 5 years or more (54.4%) than those with hypertension with less than 5 years (21.8%). Our study showed prevalence of hypertensive retinopathy to be 28.5%. Severity of hypertension and duration of hypertension > 5 years was found to have an association with hypertensive retinopathy.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"230 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74527444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current study was undertaken to see the effects of cold-water stress on the brain and to evaluate the beneficial effect of vestibular stimulation on stress-induced brain changes. Healthy, male, Wistar rats, weighing 180 to 250 gm with 3-6 months of age, were used for the study. Stress was induced by making the animals swim in cold water maintained at 100C for 30 min a day, for 14 days. Following cold water swimming stress, bilateral hot water caloric vestibular stimulation was given to the animals using 410C temperature water for 15 days. Rats were sacrificed and histopathological brain changes were studied by Hematoxylin & Eosin staining. Serum corticosterone level has increased significantly after cold water swimming stress (p<0.01). Corticosterone was less in animals that received caloric vestibular stimulation in comparison with the animals which did not receive caloric vestibular stimulation (p<0.05). Coldwater swimming stress had induced focal neuronal atrophy, nuclear pyknosis with congested blood vessels and infiltration of mononuclear inflammatory cells in the hippocampus and hypothalamus. Stressed animals that received caloric vestibular stimulation recovered well and showed the cerebral cortex with the normal neuroglial arrangement. Hypothalamus showed normal morphology and the hippocampus showed a pyramidal layer with a normal thickness in comparison to the animals which did not receive caloric vestibular stimulation. We conclude Caloric vestibular stimulation was effective in reversing the cold-water stress-induced serum corticosterone and histopathological changes in the brain.
{"title":"Effect of vestibular stimulation on cold water stress-induced neurological changes in Wistar rats","authors":"Rama Kranthi T, Archana R, Senthilkumar Sivanesan","doi":"10.26452/ijrps.v13i2.88","DOIUrl":"https://doi.org/10.26452/ijrps.v13i2.88","url":null,"abstract":"The current study was undertaken to see the effects of cold-water stress on the brain and to evaluate the beneficial effect of vestibular stimulation on stress-induced brain changes. Healthy, male, Wistar rats, weighing 180 to 250 gm with 3-6 months of age, were used for the study. Stress was induced by making the animals swim in cold water maintained at 100C for 30 min a day, for 14 days. Following cold water swimming stress, bilateral hot water caloric vestibular stimulation was given to the animals using 410C temperature water for 15 days. Rats were sacrificed and histopathological brain changes were studied by Hematoxylin & Eosin staining. Serum corticosterone level has increased significantly after cold water swimming stress (p<0.01). Corticosterone was less in animals that received caloric vestibular stimulation in comparison with the animals which did not receive caloric vestibular stimulation (p<0.05). Coldwater swimming stress had induced focal neuronal atrophy, nuclear pyknosis with congested blood vessels and infiltration of mononuclear inflammatory cells in the hippocampus and hypothalamus. Stressed animals that received caloric vestibular stimulation recovered well and showed the cerebral cortex with the normal neuroglial arrangement. Hypothalamus showed normal morphology and the hippocampus showed a pyramidal layer with a normal thickness in comparison to the animals which did not receive caloric vestibular stimulation. We conclude Caloric vestibular stimulation was effective in reversing the cold-water stress-induced serum corticosterone and histopathological changes in the brain.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74521881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The flies (Drosophila melanogaster) were segregated into four groups. 1st Group is normal-control, 2nd group is wild type flies administered with 0.01% NDEA, 3rd group is wild type flies administered with 0.01% NDEA + 0.01% Naja naja snake venom (NNV) and 4th group is flies administered with 0.01% NNV alone were administered via food medium for 21 days. After the experimental period, the behavioural changes were analyzed. The behavioural assays include negative geotaxis, phototaxis, smell chemotaxis, taste chemotaxis, thermotaxis, and hygrotaxis were carried out in all groups of flies. The behavioural changes were found to be deteriorated in NDEA administered flies when related to the control but the behaviour is likely to regularise in NDEA+NNV administered flies. The protein carbonyl levels and levels of thiobarbuturic acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably elevated in NDEA administered flies as matched to control flies and similarly be likely to regularize in the NDEA+NNV group. Likewise, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST) and reduced glutathione (GSH) were diminished in the group of NDEA administered and were noticeably more in the group of NDEA+NNV administered group. NNV has been stated to possess pharmacologically active components such as disintegrins, cobratoxin, hannalgesin, cytotoxin II, etc. which could possess antioxidant, antibacterial, hypotensive, cancer suppressive, anticoagulant, and analgesic activities. Our present study provides evidences that these components could normalize cognitive behaviour and attenuate oxidative stress in a genetically important model organism D. melanogaster.
{"title":"Influence of Indian snake (Naja naja) venom on cognition and biochemical functions in N- Nitrosodiethylamine treated Drosophila melanogaster","authors":"Leela Sudarsanan Amulya, Perumal Subramanian","doi":"10.26452/ijrps.v13i1.33","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.33","url":null,"abstract":"The flies (Drosophila melanogaster) were segregated into four groups. 1st Group is normal-control, 2nd group is wild type flies administered with 0.01% NDEA, 3rd group is wild type flies administered with 0.01% NDEA + 0.01% Naja naja snake venom (NNV) and 4th group is flies administered with 0.01% NNV alone were administered via food medium for 21 days. After the experimental period, the behavioural changes were analyzed. The behavioural assays include negative geotaxis, phototaxis, smell chemotaxis, taste chemotaxis, thermotaxis, and hygrotaxis were carried out in all groups of flies. The behavioural changes were found to be deteriorated in NDEA administered flies when related to the control but the behaviour is likely to regularise in NDEA+NNV administered flies. The protein carbonyl levels and levels of thiobarbuturic acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably elevated in NDEA administered flies as matched to control flies and similarly be likely to regularize in the NDEA+NNV group. Likewise, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST) and reduced glutathione (GSH) were diminished in the group of NDEA administered and were noticeably more in the group of NDEA+NNV administered group. NNV has been stated to possess pharmacologically active components such as disintegrins, cobratoxin, hannalgesin, cytotoxin II, etc. which could possess antioxidant, antibacterial, hypotensive, cancer suppressive, anticoagulant, and analgesic activities. Our present study provides evidences that these components could normalize cognitive behaviour and attenuate oxidative stress in a genetically important model organism D. melanogaster.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83918743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nidhi Sharma, Nasreen Banu M, Sai Supriya Muthyala
A 32-year-old multiparous female patient came to our gynaecology OPD with complaints of a painful lump over the previous caesarean scar. She had a history of two caesarean sections previously in 2012 & 2015. The last Caesarean section was done electively along with copper T insertion in 2015. In the postoperative period, she had a superficial surgical site infection which was managed successfully with antibiotics and re-suturing done on day 8 postoperative period and rest were uneventful. On per abdominal examination seen, a hyperpigmented hard indurated tender mass of 6*4cm present in the right side of scar site with 2mm orifice and chocolate brown fluid seen oozing from the orifice on pressing. Ultrasound showed a hypoechoic mass of 4*6 cm in the subcutaneous plan of the abdominal wall extending up to the anterior uterine wall with minimal vascularity. Possibility of scar endometriosis was given. Contrast-enhanced computed tomography showed defined Solid soft tissue mass of size 2*8.3*3.4 cm (CC*AP*TR) seen in the deep subcutaneous plan of the anterior abdominal wall in the hypogastric region extending to deep musculature of rectus abdominis. Rectus muscle and anterior rectus sheath closed with loop ethilon and 15*15cm trulene mesh placed as only mesh fixed with 2-0 prolene and another drain placed. The patient made a good recovery following the surgery. Histopathology report consistent with scar endometriosis showing foci of endometrial tissues consisting of cystic endometrial glands surrounded by endometrial stroma.
一名32岁的多胎女性患者来到我们的妇科门诊，抱怨以前剖腹产疤痕的疼痛肿块。她曾在2012年和2015年进行过两次剖腹产。最后一次剖腹产手术是在2015年选择性地进行的，同时还有铜T插入术。术后，患者发生手术部位浅表感染，术后第8天使用抗生素和重新缝合治疗，休息顺利。腹部检查可见，疤痕部位右侧有一个6*4cm的色素沉着、坚硬硬化的压痛肿块，有2mm的孔口，按压时可见从孔口渗出巧克力色液体。超声显示腹壁皮下4*6 cm的低回声肿块，延伸至子宫前壁，血管极少。瘢痕性子宫内膜异位症的可能性。ct增强扫描示腹前壁深层皮下2*8.3*3.4 cm (CC*AP*TR)大小的清晰实性软组织肿块，延伸至腹直肌深部。直肌和前直肌鞘用环乙基隆闭合，放置15*15cm的聚乙烯网片作为唯一的网片，用2-0丙烯固定，另放置引流管。手术后病人恢复得很好。组织病理学报告与瘢痕性子宫内膜异位症一致，显示子宫内膜组织的病灶由子宫内膜间质包围的囊性子宫内膜腺组成。
{"title":"A bizarre surgical aftermath of caesarean scar endometriosis","authors":"Nidhi Sharma, Nasreen Banu M, Sai Supriya Muthyala","doi":"10.26452/ijrps.v13i1.34","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.34","url":null,"abstract":"A 32-year-old multiparous female patient came to our gynaecology OPD with complaints of a painful lump over the previous caesarean scar. She had a history of two caesarean sections previously in 2012 & 2015. The last Caesarean section was done electively along with copper T insertion in 2015. In the postoperative period, she had a superficial surgical site infection which was managed successfully with antibiotics and re-suturing done on day 8 postoperative period and rest were uneventful. On per abdominal examination seen, a hyperpigmented hard indurated tender mass of 6*4cm present in the right side of scar site with 2mm orifice and chocolate brown fluid seen oozing from the orifice on pressing. Ultrasound showed a hypoechoic mass of 4*6 cm in the subcutaneous plan of the abdominal wall extending up to the anterior uterine wall with minimal vascularity. Possibility of scar endometriosis was given. Contrast-enhanced computed tomography showed defined Solid soft tissue mass of size 2*8.3*3.4 cm (CC*AP*TR) seen in the deep subcutaneous plan of the anterior abdominal wall in the hypogastric region extending to deep musculature of rectus abdominis. Rectus muscle and anterior rectus sheath closed with loop ethilon and 15*15cm trulene mesh placed as only mesh fixed with 2-0 prolene and another drain placed. The patient made a good recovery following the surgery. Histopathology report consistent with scar endometriosis showing foci of endometrial tissues consisting of cystic endometrial glands surrounded by endometrial stroma.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78683477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Graph theory had wide applications in developing in silico tools and it is widely used to calculate topological indices to establish structural activity relations of chemicals/compounds. However, usage of Zagreb indices with respect to natural compounds activity/toxicity prediction needs more attention. Many available online tools are using atom bond connectivity index (ABC Index), first and second Zagreb indices. The usage of the Hyper Zagreb index is very rare and using natural compounds is neglected. In this context, three types of Zagreb indices (first Zagreb index, second Zagreb index and hyper Zagreb index) were calculated to the selected chemical compounds of natural products and the relation between these indices and cytotoxicity of natural compounds were established. We have selected IC50 Values of the selected natural compounds in Hela cell lines as an index for cytotoxicity from the literature. The correlation of Zagreb indices and activity was performed using the R program, and we reached the conclusion that all indices correlate with the cytotoxicity of the studied compounds. This study acts as evidence to prove that, hyper Zagreb index correlates more with the cytotoxicity/activity of the studied natural compounds. Further studies using other Machine Learning tools to verify these findings will establish the importance of the hyper Zagreb index as one method to predict the toxicity of natural compounds.
{"title":"A Statistical Comparison between Zagreb indices for correlation with toxicity predictions of natural products","authors":"Siva Parvathi M., Sujatha D., Sukeerthi T.","doi":"10.26452/ijrps.v13i1.32","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.32","url":null,"abstract":"Graph theory had wide applications in developing in silico tools and it is widely used to calculate topological indices to establish structural activity relations of chemicals/compounds. However, usage of Zagreb indices with respect to natural compounds activity/toxicity prediction needs more attention. Many available online tools are using atom bond connectivity index (ABC Index), first and second Zagreb indices. The usage of the Hyper Zagreb index is very rare and using natural compounds is neglected. In this context, three types of Zagreb indices (first Zagreb index, second Zagreb index and hyper Zagreb index) were calculated to the selected chemical compounds of natural products and the relation between these indices and cytotoxicity of natural compounds were established. We have selected IC50 Values of the selected natural compounds in Hela cell lines as an index for cytotoxicity from the literature. The correlation of Zagreb indices and activity was performed using the R program, and we reached the conclusion that all indices correlate with the cytotoxicity of the studied compounds. This study acts as evidence to prove that, hyper Zagreb index correlates more with the cytotoxicity/activity of the studied natural compounds. Further studies using other Machine Learning tools to verify these findings will establish the importance of the hyper Zagreb index as one method to predict the toxicity of natural compounds.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88209817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our study aimed to analyze and compare monthly costs along with cost variation between Ayurveda and Allopathy medicines used to treat 2 chronic disease conditions, viz. Rheumatoid Arthritis and Hypertension. The prices of Allopathic & Ayurvedic drugs mentioned in the treatment guidelines for these 2 conditions were obtained from different sources. The minimum and the maximum cost of a particular drug of the same strength manufactured by various pharmaceutical companies were noted for both Ayurvedic and as Allopathic medicines. Cost Ratio and percent Cost Variation were also calculated. The results showed that the percent Cost Variation Difference (%CVD) for ayurvedic medicines for Anti-Rheumatoid arthritis ranged from 105% to 166.33%. In the case of Allopathic drugs, the %CVD ranged from 182% for DMARDs to 1184.39% for Corticosteroids. In the case of Anti-hypertensive medicines, too, the mean %CVD ranged from 84.21% for Rasaushadhi to 353.33% for Arishta, while %CVD ranged from 150.70% for ACE inhibitors to 269.85% for Calcium channel blockers for Ayurvedic and Allopathic medicines, respectively. A comparison of the monthly medicine cost for Rheumatoid Arthritis in Ayurveda and Allopathy showed that the cost for Ayurveda medicine ranged from ₹993.16 to ₹1994 while that for Allopathic medicines ranged from ₹735.53 to ₹2634.57. In the case of hypertension, the monthly medicine cost ranged from ₹255.64 to 2136.35 depending on the grade of Hypertension for Ayurvedic medicines and ₹312.65 to ₹631.15 for Allopathic medicines. Thus, we can conclude that there is a wide difference in the prices of the various brands of the same oral Antihypertensive and Anti-Rheumatoid arthritis drugs available in both Ayurveda and Allopathy in the Indian market.
{"title":"A Cost Comparison and Cost Variation Analysis of Anti Rheumatoid Drugs and Anti-Hypertensive Drugs in Ayurveda and Allopathy","authors":"Renuka Munshi, Vivek Singh","doi":"10.26452/ijrps.v13i1.28","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.28","url":null,"abstract":"Our study aimed to analyze and compare monthly costs along with cost variation between Ayurveda and Allopathy medicines used to treat 2 chronic disease conditions, viz. Rheumatoid Arthritis and Hypertension. The prices of Allopathic & Ayurvedic drugs mentioned in the treatment guidelines for these 2 conditions were obtained from different sources. The minimum and the maximum cost of a particular drug of the same strength manufactured by various pharmaceutical companies were noted for both Ayurvedic and as Allopathic medicines. Cost Ratio and percent Cost Variation were also calculated. The results showed that the percent Cost Variation Difference (%CVD) for ayurvedic medicines for Anti-Rheumatoid arthritis ranged from 105% to 166.33%. In the case of Allopathic drugs, the %CVD ranged from 182% for DMARDs to 1184.39% for Corticosteroids. In the case of Anti-hypertensive medicines, too, the mean %CVD ranged from 84.21% for Rasaushadhi to 353.33% for Arishta, while %CVD ranged from 150.70% for ACE inhibitors to 269.85% for Calcium channel blockers for Ayurvedic and Allopathic medicines, respectively. A comparison of the monthly medicine cost for Rheumatoid Arthritis in Ayurveda and Allopathy showed that the cost for Ayurveda medicine ranged from ₹993.16 to ₹1994 while that for Allopathic medicines ranged from ₹735.53 to ₹2634.57. In the case of hypertension, the monthly medicine cost ranged from ₹255.64 to 2136.35 depending on the grade of Hypertension for Ayurvedic medicines and ₹312.65 to ₹631.15 for Allopathic medicines. Thus, we can conclude that there is a wide difference in the prices of the various brands of the same oral Antihypertensive and Anti-Rheumatoid arthritis drugs available in both Ayurveda and Allopathy in the Indian market. ","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"491 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79945109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sapota is popular in a number of countries for its delicious, soft, sweet and luscious fruits. Although several varieties of sapota are under commercial cultivation in India, information on nutritional profiling of fruit and the associated health benefits have not been investigated. Hence, the present study was carried out to evaluate seven commercial varieties of sapota for their nutritional characteristics with a view to better exploit sapota fruits for their health benefits. A notable feature of the study was that the varieties Kalipati, Guthi and CO2 had significantly higher levels of the micro elements Fe, Cu and Zn respectively which could be exploited for treating mineral deficiency symptoms in human patients. The separation and identification of high levels of minerals and phytonutrients like, total phenol, total flavonoids, anthocyanins, fatty acids and free radical scavenging activity in fruit pulp showed that sapota fruit is nutritionally a rich fruit with many phytochemicals which are beneficial in both health and disease. The principal component analysis could successfully identify varieties with the largest amount of phytonutrients having specific health benefits.
{"title":"Nutritional Content and Antioxidant Properties of Sapota (Manilkara Achras Forb.) Fruit Varieties","authors":"Sudha Durairajan, Malarkodi Raja","doi":"10.26452/ijrps.v13i1.24","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.24","url":null,"abstract":"Sapota is popular in a number of countries for its delicious, soft, sweet and luscious fruits. Although several varieties of sapota are under commercial cultivation in India, information on nutritional profiling of fruit and the associated health benefits have not been investigated. Hence, the present study was carried out to evaluate seven commercial varieties of sapota for their nutritional characteristics with a view to better exploit sapota fruits for their health benefits. A notable feature of the study was that the varieties Kalipati, Guthi and CO2 had significantly higher levels of the micro elements Fe, Cu and Zn respectively which could be exploited for treating mineral deficiency symptoms in human patients. The separation and identification of high levels of minerals and phytonutrients like, total phenol, total flavonoids, anthocyanins, fatty acids and free radical scavenging activity in fruit pulp showed that sapota fruit is nutritionally a rich fruit with many phytochemicals which are beneficial in both health and disease. The principal component analysis could successfully identify varieties with the largest amount of phytonutrients having specific health benefits.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77447879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulaziz Khaled Hasan, Rakesh Kumar Jat, Abdul Mannan Khan
The study was to investigate the antidiabetic of aqueous extract of leaves of plant Aloe barbadensis. In STZ induced diabetes in rats, a study was conducted on six groups of six male Wister rats each to evaluate the hypoglycaemic effect. Diabetes was induced in rodents by intravenous (i.v) infusion of STZ at a portion of 50 mg/kg body weight, disintegrated in 00.10M virus citrate cushion (pH = 04.50). Blood glucose level was estimated utilizing GOD-POD (Kit spin react). Blood tests were pulled back from the retro-orbital plexus under light ether. A. barbadensis (ALEC) was exposed to hostile to diabetic action in rodents where STZ was utilized as a portion of 120 mg/kg in intraperitoneal portion as a diabetogenic specialist to an acquainted diabetic with test rodents. In intense streptozotocin prompted models fasting blood glucose level was recorded on multi-day as basal worth 4th, 7th and 10th day. Aqueous extracts of leaves of A. barbadensis at portion 250 and 500 mg/kg showed portion subordinate critical enemy of hyperglycemic action on 4th, 7th and 10th day post-treatment. ALEC portion of 100 mg/kg likewise caused a decrease in blood glucose level; however, outcomes were found factually non-noteworthy. The Antihyperglycemic impact of fluid leaves concentrate of A. barbadensis at portion 100 mg/kg was discovered less viable than reference standard medications glibenclamide. The most extreme decrease was seen on the 10th day of the greatest portion of 500 mg/kg ALEC. Glibenclamide produces a critical decrease in blood glucose level in contrast with diabetic control. Glibenclamide was used as a standard drug, and the results were compared in reference to it. The study confirmed the aqueous extract of Aloe barbadensis has significant and sustained oral hypoglycaemic activity, comparable with the hypoglycaemic effect of glibenclamide, a sulfonylurea derivative.
{"title":"Effects of aqueous leaves extract of Aloe barbadensis on blood glucose levels of streptozocin-induced diabetic Wistar rats","authors":"Abdulaziz Khaled Hasan, Rakesh Kumar Jat, Abdul Mannan Khan","doi":"10.26452/ijrps.v13i1.23","DOIUrl":"https://doi.org/10.26452/ijrps.v13i1.23","url":null,"abstract":"The study was to investigate the antidiabetic of aqueous extract of leaves of plant Aloe barbadensis. In STZ induced diabetes in rats, a study was conducted on six groups of six male Wister rats each to evaluate the hypoglycaemic effect. Diabetes was induced in rodents by intravenous (i.v) infusion of STZ at a portion of 50 mg/kg body weight, disintegrated in 00.10M virus citrate cushion (pH = 04.50). Blood glucose level was estimated utilizing GOD-POD (Kit spin react). Blood tests were pulled back from the retro-orbital plexus under light ether. A. barbadensis (ALEC) was exposed to hostile to diabetic action in rodents where STZ was utilized as a portion of 120 mg/kg in intraperitoneal portion as a diabetogenic specialist to an acquainted diabetic with test rodents. In intense streptozotocin prompted models fasting blood glucose level was recorded on multi-day as basal worth 4th, 7th and 10th day. Aqueous extracts of leaves of A. barbadensis at portion 250 and 500 mg/kg showed portion subordinate critical enemy of hyperglycemic action on 4th, 7th and 10th day post-treatment. ALEC portion of 100 mg/kg likewise caused a decrease in blood glucose level; however, outcomes were found factually non-noteworthy. The Antihyperglycemic impact of fluid leaves concentrate of A. barbadensis at portion 100 mg/kg was discovered less viable than reference standard medications glibenclamide. The most extreme decrease was seen on the 10th day of the greatest portion of 500 mg/kg ALEC. Glibenclamide produces a critical decrease in blood glucose level in contrast with diabetic control. Glibenclamide was used as a standard drug, and the results were compared in reference to it. The study confirmed the aqueous extract of Aloe barbadensis has significant and sustained oral hypoglycaemic activity, comparable with the hypoglycaemic effect of glibenclamide, a sulfonylurea derivative.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77553889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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