Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13344
A. Pramono, Rr. Sinta Irina, B. Lubis
- Background : Thiamine may be considered as adjunctive therapy in patients with sepsisThiamine administration reduced the Matrix metalloproteinase 9 / Tissue inhibitors of matrix metalloproteinase 1 (TIMP-1/MMP-9) ratio, which could be associated with better survival. Thiamine can reduce Interleukin-6 (IL-6) levels in patients with sepsis. Thiamine is negatively correlated with lactate levels, thiamine deficiency significantly increases lactate levels. Destination
{"title":"The Relationship Between Thiamin Administration And Lactic Acid In Sepsis Patients In The Icu Of H. Adam Malik Hospital","authors":"A. Pramono, Rr. Sinta Irina, B. Lubis","doi":"10.29322/ijsrp.13.01.2023.p13344","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13344","url":null,"abstract":"- Background : Thiamine may be considered as adjunctive therapy in patients with sepsisThiamine administration reduced the Matrix metalloproteinase 9 / Tissue inhibitors of matrix metalloproteinase 1 (TIMP-1/MMP-9) ratio, which could be associated with better survival. Thiamine can reduce Interleukin-6 (IL-6) levels in patients with sepsis. Thiamine is negatively correlated with lactate levels, thiamine deficiency significantly increases lactate levels. Destination","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13309
Chimbishi Fortune
- This article acknowledges that land reform is critical in the development and transformation of economies especially in Sub Saharan Africa. (SSA). Land reform is a planned purposive change in the way land tenure is held or owned. It also includes the methods of cultivation that are employed and in a way, defines the relation of agriculture to the rest of the economy. Like most economies in Sub Saharan Africa (SSA), agriculture in Zimbabwe plays an important role in the country’s economy and also on the livelihoods of the rural populace whose quest for food security and nutrition, income and expansion of their rural economies is embedded in agriculture. This is clearly spelt out in the Zimbabwe’s economic blue print, the National Development Strategy One (NDS1) where agriculture forms the important enabler for the country’s social and economic transformation by the second Republic of President Emmerson Mnangagwa. Farmers under the A1 model of Zimbabwe’s Fast Track Land Reform Programme (FTLRP) have engaged in Farmer Led-Irrigation (FLI) initiatives to complement irrigation programmes by the Government of Zimbabwe. The main goal of these initiatives is to increase crop productivity that invariably enhances small holder farmers’ livelihoods. Rainfall agriculture has proven to be unreliable in the face of climate
{"title":"Farmer Perceptions On The Impact Of Farmer Led-Irrigation Initiatives On Crop Production Under Redistributed Lands: A Case Study Of Mazowe District A1 Resettled Farmers, Zimbabwe","authors":"Chimbishi Fortune","doi":"10.29322/ijsrp.13.01.2023.p13309","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13309","url":null,"abstract":"- This article acknowledges that land reform is critical in the development and transformation of economies especially in Sub Saharan Africa. (SSA). Land reform is a planned purposive change in the way land tenure is held or owned. It also includes the methods of cultivation that are employed and in a way, defines the relation of agriculture to the rest of the economy. Like most economies in Sub Saharan Africa (SSA), agriculture in Zimbabwe plays an important role in the country’s economy and also on the livelihoods of the rural populace whose quest for food security and nutrition, income and expansion of their rural economies is embedded in agriculture. This is clearly spelt out in the Zimbabwe’s economic blue print, the National Development Strategy One (NDS1) where agriculture forms the important enabler for the country’s social and economic transformation by the second Republic of President Emmerson Mnangagwa. Farmers under the A1 model of Zimbabwe’s Fast Track Land Reform Programme (FTLRP) have engaged in Farmer Led-Irrigation (FLI) initiatives to complement irrigation programmes by the Government of Zimbabwe. The main goal of these initiatives is to increase crop productivity that invariably enhances small holder farmers’ livelihoods. Rainfall agriculture has proven to be unreliable in the face of climate","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76728177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13328
B. Cruz
- Covid-19 pandemic has greatly affected the agricultural sector in the Philippines. As the production of rice is affected by the lockdown, the Filipino farmers also suffered. The pandemic and the lockdown imposed in response to it have added to the burden for farmers and traders, whose movements are now restricted. In this study, the researchers aimed to give light to the experiences of the local farmers during the pandemic. These experiences are mainly focused on the effect of the pandemic on their livelihood, financial status, and their mental health. The data was collected through interviews by giving them questionnaires. The responses from the 16 respondents were analyzed to answer the study’s research questions. The data showed that person aged 41-45 were more dominant in farming than the person who aged 26-40 and 60 years old and above of the key-participants of the conducted study. The findings showed that most of the farmers have the same struggles experienced during the pandemic. These struggles are due to lack of equipment, drying of crops, pests, and the added burden of strict protocols that were implemented by the government. Many of them also expressed that their income became lower during the pandemic because of the low production of goods since there are less farmers
{"title":"Covid-19 Hits the Unsung Heroes: The Encountered Hardships of Farmers in Times of Pandemic","authors":"B. Cruz","doi":"10.29322/ijsrp.13.01.2023.p13328","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13328","url":null,"abstract":"- Covid-19 pandemic has greatly affected the agricultural sector in the Philippines. As the production of rice is affected by the lockdown, the Filipino farmers also suffered. The pandemic and the lockdown imposed in response to it have added to the burden for farmers and traders, whose movements are now restricted. In this study, the researchers aimed to give light to the experiences of the local farmers during the pandemic. These experiences are mainly focused on the effect of the pandemic on their livelihood, financial status, and their mental health. The data was collected through interviews by giving them questionnaires. The responses from the 16 respondents were analyzed to answer the study’s research questions. The data showed that person aged 41-45 were more dominant in farming than the person who aged 26-40 and 60 years old and above of the key-participants of the conducted study. The findings showed that most of the farmers have the same struggles experienced during the pandemic. These struggles are due to lack of equipment, drying of crops, pests, and the added burden of strict protocols that were implemented by the government. Many of them also expressed that their income became lower during the pandemic because of the low production of goods since there are less farmers","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80781440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13341
Sri Agusti, M. M. Amin, V. Camellia
- Background: Osteoarthritis (OA) is the most common articular disease in developed countries and the leading cause of chronic disability, mostly knee OA. It’s chronic nature results in significant physical and psychological burden, including the development of depressive symptoms. In this present study we aimed to investigate factors related to the development of depressive symptoms in individuals with knee OA. 120 knee OA outpatients were obtained consecutively in this cross sectional study. Multiple linear regression was then used to assess relationships of independent risk factors to depressive symptoms severity measured with Patient Health Questionnaire (PHQ-9). The final multivariate result in the model that fit the factors associated with depression in knee OA patients were income with p value = 0.012 and r value = -0.152, employment with p < 0.001 and r value = -0.473, BMI with p value < 0.001 and r value = 0.233 were found to contribute to depressive symptom scores for as much as 73.5%. Income, employment, and BMI are independent factors related to depressive score.
{"title":"Depressive Symptoms Among Individuals With Knee Osteoarthritis","authors":"Sri Agusti, M. M. Amin, V. Camellia","doi":"10.29322/ijsrp.13.01.2023.p13341","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13341","url":null,"abstract":"- Background: Osteoarthritis (OA) is the most common articular disease in developed countries and the leading cause of chronic disability, mostly knee OA. It’s chronic nature results in significant physical and psychological burden, including the development of depressive symptoms. In this present study we aimed to investigate factors related to the development of depressive symptoms in individuals with knee OA. 120 knee OA outpatients were obtained consecutively in this cross sectional study. Multiple linear regression was then used to assess relationships of independent risk factors to depressive symptoms severity measured with Patient Health Questionnaire (PHQ-9). The final multivariate result in the model that fit the factors associated with depression in knee OA patients were income with p value = 0.012 and r value = -0.152, employment with p < 0.001 and r value = -0.473, BMI with p value < 0.001 and r value = 0.233 were found to contribute to depressive symptom scores for as much as 73.5%. Income, employment, and BMI are independent factors related to depressive score.","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84679674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13353
Millicent Otieno, P. K. Mutundu
: Very little has been achieved in terms of poverty reduction, despite the many Self-Help groups that have been formed and operate in Bondo Sub-County due to financial constraints that affect many women. Thus, the study explored the influence of access to credit on reduction of poverty among women groups in Bondo sub-county. The study used a descriptive survey research design using 150 women groups in Bondo Sub-county. Through stratified random sampling, the groups were selected from the five wards in the sub-county. Quantitative data was collected using questionnaires and interviews. Statistical Package for Social Sciences (SPSS) version 24.0 was used for data analysis. The study also found that there was a significant association between collateral and poverty reduction since the computed p value of 0.011 is less than 0.05 at 95% confidence level. The study recommends that stakeholders such as government and financial institutions make it easier for women to access credit. Finally, the study recommends that the women groups find other avenues of investment so as to diversify their operations.
{"title":"Does access to Credit matter in Reduction of Poverty? Evidence from the Women Groups in Bondo Sub-county","authors":"Millicent Otieno, P. K. Mutundu","doi":"10.29322/ijsrp.13.01.2023.p13353","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13353","url":null,"abstract":": Very little has been achieved in terms of poverty reduction, despite the many Self-Help groups that have been formed and operate in Bondo Sub-County due to financial constraints that affect many women. Thus, the study explored the influence of access to credit on reduction of poverty among women groups in Bondo sub-county. The study used a descriptive survey research design using 150 women groups in Bondo Sub-county. Through stratified random sampling, the groups were selected from the five wards in the sub-county. Quantitative data was collected using questionnaires and interviews. Statistical Package for Social Sciences (SPSS) version 24.0 was used for data analysis. The study also found that there was a significant association between collateral and poverty reduction since the computed p value of 0.011 is less than 0.05 at 95% confidence level. The study recommends that stakeholders such as government and financial institutions make it easier for women to access credit. Finally, the study recommends that the women groups find other avenues of investment so as to diversify their operations.","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82886674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13320
Chol Gabriel Majer
: This study examines leadership style of management on managerial strategy in public sector in South Sudan. The research used mixed method approach with descriptive method to determine the effect of leadership styles on managerial strategy. The population of the study comprised of all the 50 staffs with sample size of 45 respondents. Simple random sampling as well as purposive and convenience sampling techniques were used in this research. Questionnaires were used to collect data on leadership style and employee performance both quantitatively and qualitatively. SPSS software was used to calculate simple analysis. Themes were also developed from the interview transcriptions. The results from both analysis show that all the leadership styles do not have any effect on leadership style of management on managerial strategy in public sector. This study uses a cross-sectional study design to gather data from the respondents using a survey questionnaire. Following data cleaning and screening, data analysis was carried out on a total sample size of 45 eligible respondents. This study found that managerial leadership style had a minimal impact on managerial strategy in South Sudan's public sector. The study also recommends that when managing the institution, managers and supervisors consider the effect of management leadership style on managerial strategy in the public and private sector. in order to conduct additional research on management leadership style and its fascinating new field of influence on managerial strategy in the public sector.
{"title":"Influence Of Leadership Style Of Management On Managerial Strategy In South Sudan Public Sector","authors":"Chol Gabriel Majer","doi":"10.29322/ijsrp.13.01.2023.p13320","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13320","url":null,"abstract":": This study examines leadership style of management on managerial strategy in public sector in South Sudan. The research used mixed method approach with descriptive method to determine the effect of leadership styles on managerial strategy. The population of the study comprised of all the 50 staffs with sample size of 45 respondents. Simple random sampling as well as purposive and convenience sampling techniques were used in this research. Questionnaires were used to collect data on leadership style and employee performance both quantitatively and qualitatively. SPSS software was used to calculate simple analysis. Themes were also developed from the interview transcriptions. The results from both analysis show that all the leadership styles do not have any effect on leadership style of management on managerial strategy in public sector. This study uses a cross-sectional study design to gather data from the respondents using a survey questionnaire. Following data cleaning and screening, data analysis was carried out on a total sample size of 45 eligible respondents. This study found that managerial leadership style had a minimal impact on managerial strategy in South Sudan's public sector. The study also recommends that when managing the institution, managers and supervisors consider the effect of management leadership style on managerial strategy in the public and private sector. in order to conduct additional research on management leadership style and its fascinating new field of influence on managerial strategy in the public sector.","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"1999 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88251089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13310
Noor Abdi Mohamud, P. K. Mutundu
: The developing nations around the world have increased their efforts and rechanneled resources to gain some degree of development objective, in particular, the reduction of poverty at the same time promoting investment in human capital. In Dhusamareb of Somalia, as it happens elsewhere in Somalia and other developing nations, women are usually assigned the duty to take care of extended families, maintain the household under dire conditions, and stock supplies. In most cases, it is the Women who are left behind to feed themselves and their families including the children and the old at times of crisis and scarcity. In most cases, women find themselves with a burden. Therefore, the study examined the influence of NGO-supported cash transfer programs on poverty reduction among Women in Dhusamareb, Galmudug State, Somalia. This study collected data using in-depth interviews and questionnaires. Quantitative data was analyzed data were then presented in frequency tables, bar graphs and pie charts. Narrative and creation of themes was used in the analysis of qualitative data. the women were to be agents of change in their families and community at large. The program provided them with opportunities to train in business. The business training gave them skills in tailoring, hairdressing and business management. The study recommends that other programs should accompany cash transfers, for instance, beneficiaries on unconditional cash transfer should move to the next step of having some conditions for cash transfer as they gain substantial stability.
{"title":"Strategic Approach to Poverty Reduction among Women: The Use of NGO-supported Cash Transfer Programs in Dhusamareb, Galmudug State, Somalia","authors":"Noor Abdi Mohamud, P. K. Mutundu","doi":"10.29322/ijsrp.13.01.2023.p13310","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13310","url":null,"abstract":": The developing nations around the world have increased their efforts and rechanneled resources to gain some degree of development objective, in particular, the reduction of poverty at the same time promoting investment in human capital. In Dhusamareb of Somalia, as it happens elsewhere in Somalia and other developing nations, women are usually assigned the duty to take care of extended families, maintain the household under dire conditions, and stock supplies. In most cases, it is the Women who are left behind to feed themselves and their families including the children and the old at times of crisis and scarcity. In most cases, women find themselves with a burden. Therefore, the study examined the influence of NGO-supported cash transfer programs on poverty reduction among Women in Dhusamareb, Galmudug State, Somalia. This study collected data using in-depth interviews and questionnaires. Quantitative data was analyzed data were then presented in frequency tables, bar graphs and pie charts. Narrative and creation of themes was used in the analysis of qualitative data. the women were to be agents of change in their families and community at large. The program provided them with opportunities to train in business. The business training gave them skills in tailoring, hairdressing and business management. The study recommends that other programs should accompany cash transfers, for instance, beneficiaries on unconditional cash transfer should move to the next step of having some conditions for cash transfer as they gain substantial stability.","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13312
Amjad Ali Zalah, Fairs Ali Essa Ghazi, Mohammed A Khayri, Ali Ibrahim Marzouq, Muhammed Ibrahim Muhammed Shabi, A. A. Zahrani, Hasan Gailan Hasan Qinaee, I. Mobarki, Mohammedalbadr M. Khawaji, Hatim Mohammed Khobrani, Nasser Ahmad Albarati, Ibrahim Mohammed Ahmed Jaafari, Taher Essa Jaafary, Turki Mohammed Khawaji, Hussain Ahmed Mohammed Qadi, Adel ahmed sak, Nasser Deban alhodal, Abdulrahman Ahmed Ibrahim Khormi
- Healthcare-associated infections are the most common kind of patient harm in hospitals. Although 5–10% of hospitalized patients in developed countries have similar infections, the burden of disease is much higher in low-and middle-income countries. Preventing the spread of infectious diseases requires widespread, systematic use of hygiene practices by healthcare workers, but only around 40% of those who should comply actually do so. There are several reasons why hand cleaning is so important in a healthcare setting. It prevents patients from catching infectious diseases that originate inside their bodies as well as those brought in from outside, as well as
{"title":"A Strategy To Prevent Acute Infections In Health Care Associations","authors":"Amjad Ali Zalah, Fairs Ali Essa Ghazi, Mohammed A Khayri, Ali Ibrahim Marzouq, Muhammed Ibrahim Muhammed Shabi, A. A. Zahrani, Hasan Gailan Hasan Qinaee, I. Mobarki, Mohammedalbadr M. Khawaji, Hatim Mohammed Khobrani, Nasser Ahmad Albarati, Ibrahim Mohammed Ahmed Jaafari, Taher Essa Jaafary, Turki Mohammed Khawaji, Hussain Ahmed Mohammed Qadi, Adel ahmed sak, Nasser Deban alhodal, Abdulrahman Ahmed Ibrahim Khormi","doi":"10.29322/ijsrp.13.01.2023.p13312","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13312","url":null,"abstract":"- Healthcare-associated infections are the most common kind of patient harm in hospitals. Although 5–10% of hospitalized patients in developed countries have similar infections, the burden of disease is much higher in low-and middle-income countries. Preventing the spread of infectious diseases requires widespread, systematic use of hygiene practices by healthcare workers, but only around 40% of those who should comply actually do so. There are several reasons why hand cleaning is so important in a healthcare setting. It prevents patients from catching infectious diseases that originate inside their bodies as well as those brought in from outside, as well as","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87960171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13352
Nassir Mohammed Aden, P. K. Mutundu
{"title":"Influence of Inter-Governmental Organizations on the Performance of the Independent Boundaries and Elections Commission (IEBC) of Kenya in the Electoral Processes","authors":"Nassir Mohammed Aden, P. K. Mutundu","doi":"10.29322/ijsrp.13.01.2023.p13352","DOIUrl":"https://doi.org/10.29322/ijsrp.13.01.2023.p13352","url":null,"abstract":"","PeriodicalId":14290,"journal":{"name":"International Journal of Scientific and Research Publications (IJSRP)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81641165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.29322/ijsrp.13.01.2023.p13305
J. Chrestella, Marlina Sinaga
: Background: During pregnancy, SARS Coronavirus 2 infection may cause an abnormal development of the placenta, thus influencing maternal and fetal outcomes. Placental pathology in the setting of maternal SARS-CoV-2 infection remains a topic of great interest because the raising concern for vertical transmission and earlier studies have shown mixed results Objective: We present series of 28 placentas of SARS-CoV-2 positive women who had been diagnosed by RT PCR in Haji Adam Malik General Hospital as one major goverment hospital for COVID-19 management in Medan, North Sumatera, Indonesia from February-August 2021. Methods: All placentas were microscopically examined with H&E-stained sections, which usually included full-thickness sections that included fetal and maternal surfaces and one section with two umbilical cord sections and membrane rolls. Results: Pathologic findings were divided into maternal vascular malperfusion, fetal vascular malperfusion, chronic inflammatory lesions, amniotic fluid infection sequence, increased perivillous fibrin, intervillous thrombi, increased subchorionic fibrin, meconium-laden macrophages within fetal membranes, and chorangiosis. Mostly, the placentas showed prominent signs of increased fibrin deposition in perivillous and intervillous thrombus (92,9 % and 82,1%), but not many showed lymphohistiocytic villitis (10,7%) respectively, as reported in other studies. Conclusions: Limited conclusions can be drawn about the effect of maternal SARS-CoV-2 infection on placental pathology. Based on the data in this study, we report general histopathological features, which include maternal vascular malperfusion, fetal vascular malperfusion, inflammation and thrombus in placentas with COVID-19 infection. A prospective cohort study with a larger sample population with thorough placental examination is needed to understand the impact of SARS-CoV-2 on the placenta, pregnancy and possible fetal sequelae.
背景:在妊娠期间，SARS冠状病毒2感染可导致胎盘发育异常，从而影响母体和胎儿的结局。在母体感染SARS-CoV-2的情况下，胎盘病理学仍然是一个非常有趣的话题，因为对垂直传播的关注日益增加，早期的研究显示了不同的结果。目的:我们在2021年2月至8月期间，在印度尼西亚北苏门答腊棉兰的哈吉亚当马利克综合医院(Haji Adam Malik General Hospital)通过RT - PCR诊断出SARS-CoV-2阳性妇女的28个胎盘。方法:采用h&e染色切片对所有胎盘进行显微镜检查，通常包括包括胎儿和母体表面的全层切片，以及一个包含两个脐带切片和膜卷的切片。结果:病理表现分为母体血管灌注不良、胎儿血管灌注不良、慢性炎性病变、羊水感染顺序、绒毛周围纤维蛋白增高、绒毛间血栓、绒毛膜下纤维蛋白增高、胎膜内载胎粪巨噬细胞增多、绒毛膜增生。大多数情况下，胎盘表现出明显的纤维蛋白沉积增加的迹象，绒毛周围和绒毛间血栓(92.9%和82.1%)，但并不多表现为淋巴组织细胞性绒毛炎(10.7%)，其他研究报道。结论:母体感染SARS-CoV-2对胎盘病理的影响尚不明确。根据本研究的数据，我们报告了COVID-19感染胎盘的一般组织病理学特征，包括母体血管灌注不良、胎儿血管灌注不良、炎症和血栓。为了了解SARS-CoV-2对胎盘、妊娠和可能的胎儿后遗症的影响，需要在更大样本人群中进行前瞻性队列研究，并进行彻底的胎盘检查。
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