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Repigmentation of vitiligo universalis masquerading as pseudo-melasma
Pub Date : 2023-06-26 DOI: 10.18203/issn.2455-4529.intjresdermatol20231831
Bushra Muna, Srikanth Shanmugam
Vitiligo is a common depigmentation disorder that affects the melanocytes. We present a case of middle-aged female with complaints of pigmented lesion over both cheeks. Clinical differentials of melasma, pregnancy induced hypertension (PIH) was considered but which on further evaluation turned out to be re-pigmentation in vitiligo universalis that had developed during her postpartum which masqueraded as melasma.
白癜风是一种常见的影响黑色素细胞的色素脱失性疾病。我们提出的情况下,中年女性投诉色素病变在双颊。考虑了黄褐斑的临床鉴别,妊娠高血压(PIH),但进一步评估发现,这是产后发展的普遍白癜风再色素沉着,伪装成黄褐斑。
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引用次数: 0
The association of cytosine-adenine-guanine repeat polymorphism in the androgen receptor gene with nodulocystic acne in Egyptian patients 雄激素受体基因中胞嘧啶-腺嘌呤-鸟嘌呤重复多态性与埃及患者结节性痤疮的关系
Pub Date : 2023-06-26 DOI: 10.18203/issn.2455-4529.intjresdermatol20231823
Nehal M. Zuelfakkar, N. Ragab, A. Shehab, Momena Nagy
Background: The role of androgens in acne pathophysiology has been supported by long-standing clinical and experimental observations.Methods: Genotyping for the androgen receptor gene was performed by PCR-based fragment length analysis, aiming to investigate cytosine-adenine-guanine (CAG) repeat polymorphism in Egyptian nodulocystic acne patients to clarify its relevance to the pathogenesis. Detailed frequency of CAG repeats number in patients and control groups, in 25 males and 25 females and Comparison of CAG repeat number regarding demographic and clinical characteristics was performed.Results: It was found that females had a higher frequency of longer CAG repeats compared to males, while in control group there was an even distribution of CAG number repeats in both females and males. Male and female acne patients had significantly lower number of CAG repeats compared to controls with statistically significant difference (p≤0.05). Comparison of CAG repeat number regarding demographic and clinical characteristics revealed no significant correlation or association with patients’ age, duration of acne, onset or course of the disease.Conclusions: These findings support the hypothesis that CAG repeats number affects AR activity, therefore, acne development and severity. Moreover, analysis of CAG repeats number in acne patients can be of considerable importance in the treatment strategy, indicating the role of antiandrogen therapy in acne patients.
背景:雄激素在痤疮病理生理中的作用已得到长期临床和实验观察的支持。方法:采用基于pcr的片段长度分析方法对雄激素受体基因进行分型,探讨埃及结节性痤疮患者CAG重复基因多态性与发病机制的关系。对25名男性和25名女性患者和对照组的CAG重复次数进行详细的频率分析,并比较CAG重复次数与人口学和临床特征的关系。结果:女性CAG重复数较长频率高于男性,而对照组CAG重复数在女性和男性中分布均匀。男性和女性痤疮患者CAG重复数明显低于对照组,差异有统计学意义(p≤0.05)。CAG重复数与人口统计学和临床特征的比较显示,与患者年龄、痤疮持续时间、发病或病程无显著相关性或相关性。结论:这些发现支持了CAG重复数影响AR活性,从而影响痤疮发展和严重程度的假设。此外,分析痤疮患者的CAG重复数对治疗策略具有相当重要的意义,表明抗雄激素治疗在痤疮患者中的作用。
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引用次数: 0
Association of metabolic syndrome and insulin resistance in papulosquamous diseases 丘疹鳞状病变代谢综合征与胰岛素抵抗的关系
Pub Date : 2023-06-26 DOI: 10.18203/issn.2455-4529.intjresdermatol20231826
Abhineetha Hosthota, I. U., Anila Sara Thampi, S. R, Chaganam Kavya, Chandan B. C., Bhavana Venumbaka
Background: Metabolic syndrome (MetS), insulin resistance (IR) and papulosquamous diseases with shared pathophysiology leads to conglomeration of risk factors of non-communicable diseases like cardiovascular disease (CVD) and type 2 diabetes (T2D) causing high mortality worldwide. The objective is to study the association of MetS and IR in papulosquamous diseases.Methods: It is a hospital-based case-control study conducted on 200 age-sex matched cases and controls with consent. Subjects were administered a pre-validated questionnaire, diagnosis of papulosquamous diseases was based on clinical examination and skin biopsy. MetS was diagnosed based on national cholesterol education program's- adult treatment plan iii with Asian modification for abdominal circumference criteria. Fasting serum insulin levels (FI) was used as a surrogate marker of IR.  Results: Mean serum HDL- C level was low and statistically significant (p=0.017). Mean fasting plasma glucose level was significantly higher in patients (p=0.008). Mean FI level was significant between cases and controls (p=0.013). IR was found in 76% of cases which was significantly higher than in controls (p<0.05). IR was highest in psoriasis 29% followed by LP 22%, PRP 19%, and LS 6% which was statistically significant (p<0.05). MetS was mostly found in psoriasis (17%), LP (9%) and least in PRP, LS.Conclusions: This study intends clinicians to do periodic MetS and IR evaluation in papulosquamous diseases. Thus, subclinical cases of non-communicable diseases can be detected and potential co-morbidities can be prevented.
背景:代谢综合征(MetS)、胰岛素抵抗(IR)和丘疹鳞状疾病具有共同的病理生理,导致心血管疾病(CVD)和2型糖尿病(T2D)等非传染性疾病危险因素的聚集,导致全球高死亡率。目的是研究在丘疹鳞状疾病中met和IR的关系。方法:以医院为基础的病例对照研究,对200例年龄性别匹配的病例和经同意的对照组进行研究。受试者接受预先验证的问卷调查,丘疹鳞状疾病的诊断基于临床检查和皮肤活检。MetS的诊断是基于国家胆固醇教育计划的成人治疗计划iii和亚洲修改的腹围标准。空腹血清胰岛素水平(FI)作为IR的替代指标。结果:两组患者血清HDL- C水平均较低,差异有统计学意义(p=0.017)。患者平均空腹血糖水平显著升高(p=0.008)。平均FI水平在病例和对照组之间有显著性差异(p=0.013)。IR发生率为76%,显著高于对照组(p<0.05)。银屑病患者IR最高,为29%,LP次之,为22%,PRP为19%,LS为6%,差异有统计学意义(p<0.05)。MetS主要见于银屑病(17%),LP (9%), PRP、LS最少。结论:本研究旨在临床医生对丘疹鳞状病变进行定期MetS和IR评估。因此,可以发现非传染性疾病的亚临床病例,并预防潜在的合并症。
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引用次数: 0
A real-world data analysis on the usage of paraphenylenediamine and ammonia free hair dye 对苯二胺和无氨染发剂使用情况的真实数据分析
Pub Date : 2023-06-20 DOI: 10.18203/issn.2455-4529.intjresdermatol20231795
M. Chatterjee, Vijayajyothi Mallela, Gaurav Bhaskar, Vidya T. S., Bhagyashree Mohod, Ashok Jaiswal
Background: Dyeing of hair for various reasons is a common practice across a broad age group. Most hair dyes available in the market contain para-phenylenediamine (PPD) and/or ammonia, which are proven skin and scalp irritants. A quest for better tolerable hair dyes has led to emergence of toluene-2, 5-diamine sulfate (TDS) and monoethanolamine (MEA), as a substitute to PPD and ammonia, respectively.Methods: This retrospective study was conducted on 35 participants from four centers across India to evaluate the efficacy, and tolerance of ammonia-free and PPD-free permanent hair dye.Results: A PPD-free and ammonia-free cream-based hair dye showed promising results. The color uptake following 35 minutes of application was 100% in 54.2% of the participants. The color retention was more than 95% in 74.3% participants after 8-10 shampoo washes. The adverse effects were noted to be markedly less with only a few cases experiencing itching. The participants' feedback obtained showed a conclusively high satisfaction rate. The Physicians' assessment of efficacy and safety recorded favorable scores.Conclusions: A TDS and MEA based cream hair color can be an effective and safe alternative to PPD and ammonia-based hair dye.
背景:由于各种原因染发是广泛年龄组的普遍做法。市场上大多数染发剂都含有对苯二胺(PPD)和/或氨,它们被证明对皮肤和头皮有刺激作用。对更好耐受的染发剂的追求导致了甲苯- 2,5 -硫酸二胺(TDS)和单乙醇胺(MEA)的出现,分别作为PPD和氨的替代品。方法:本回顾性研究对来自印度四个中心的35名参与者进行了评估,以评估无氨和无ppd永久性染发剂的疗效和耐受性。结果:一种不含ppd和不含氨的乳状染发剂显示出良好的效果。在35分钟的涂抹后,54.2%的参与者对颜色的吸收是100%。74.3%的参与者在洗了8-10次洗发水后,颜色保持率超过95%。不良反应被注意到明显较少,只有少数病例经历瘙痒。参与者的反馈显示了一个决定性的高满意度。医生对疗效和安全性的评估记录了有利的分数。结论:基于TDS和MEA的乳状染发剂是PPD和氨基染发剂的安全有效的替代产品。
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引用次数: 0
Efficacy of long pulse neodymium-doped yttrium aluminium garnet 1064 laser permanent hair reduction treatment in skin types V and VI Nigerian patients 长脉冲掺钕钇铝石榴石1064激光永久性脱毛治疗皮肤V型和VI型尼日利亚患者的疗效
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231159
E. Anaba, Babawale Arabambi
Background: There are no studies examining the use, safety, efficacy, effective fluence and pulse duration of Laser hair reduction in Nigerians. This study aimed to document the safety, efficacy, effective fluence and pulse duration, and the number of Laser sessions to achieve permanent hair reduction.Methods: A retrospective review of Laser hair removal in 87 FitzPatrick skin type V and VI patients from January 2017 to August 2021 using the neodymium-doped yttrium aluminium garnet (Nd:Yag). The fluence (Joules/cm3), pulse duration (msecs), Laser site and interval between Laser sessions were documented. Data was summarized using frequencies and percentage proportion. Comparison of pulse duration, fluence, and the number of sessions between different body sites was tested using analysis of variance.Results: A total of 354 laser sessions were performed in 87 patients made up of 80 females and 7 males; mean age of 35.8±9.24 years. The face was the most frequently treated site (67.5% of the sessions). The mean number of laser sessions, pulse duration and fluence were 4.07±4.22, 19.38±1.48 (msec) and 18.22±1.29 (J/cm3) respectively. An average of 6 sessions was required to achieve permanent hair reduction: the face required a significantly lower number of sessions, p=0.043.Conclusions: The long pulse Nd:Yag 1064 laser is an effective and safe Laser for hair removal in skin types V and VI. The effective, safe pulse duration and fluence are 16 to 22 msec and 15 to 20 J/cm2 respectively. The face requires fewer number of Laser sessions.
背景:目前还没有关于尼日利亚人激光脱毛的使用、安全性、有效性、有效影响和脉冲持续时间的研究。本研究旨在记录安全性、有效性、有效影响和脉冲持续时间,以及激光达到永久性脱发的次数。方法:回顾性分析2017年1月至2021年8月87例菲茨帕特里克皮肤V型和VI型患者使用掺钕钇铝石榴石(Nd:Yag)激光脱毛的情况。记录了能量(焦耳/cm3)、脉冲持续时间(毫秒)、激光位置和两次激光之间的间隔。数据汇总采用频率和百分比比例。使用方差分析对不同身体部位的脉搏持续时间、影响力和会话次数进行比较。结果:87例患者共进行了354次激光治疗,其中女性80例,男性7例;平均年龄35.8±9.24岁。面部是最常见的治疗部位(67.5%)。平均激光次数为4.07±4.22,脉冲持续时间为19.38±1.48 (msec),影响度为18.22±1.29 (J/cm3)。达到永久减毛的效果平均需要6次疗程:面部所需的疗程数量明显较低,p=0.043。结论:Nd:Yag 1064长脉冲激光是V、VI类皮肤脱毛的有效、安全激光,有效、安全脉冲持续时间为16 ~ 22 msec,脉冲能量为15 ~ 20 J/cm2。面部需要较少的激光疗程。
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引用次数: 0
An institution-based non-randomised prospective study to estimate the efficacy and adverse effect profile of apremilast for moderate to severe refractory palmoplantar psoriasis 一项基于机构的非随机前瞻性研究,旨在评估阿普米司特治疗中度至重度难治性掌跖牛皮癣的疗效和不良反应
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231163
N. Agrawal, Sabina Liangom Joanna Rongong, S. Halder, J. Barua, Param Satsangi, A. Halder, Prabal Samanta
Background: Psoriasis is an immune-mediated inflammatory papulo-squamous disorder presenting as chronic plaque, pustular, erythrodermic, nail, scalp, drug induced, inverse, guttate etc. Palmoplantar psoriasis causes significant functional, cosmetic and psychological disability. Apremilast is a relatively newer drug being PDE-4 inhibitor, having negligible adverse effects with minimum blood monitoring.Methods: It is an institution-based, non-randomised, prospective study conducted over a period of 3 months. 42 patients of moderate to severe disease (assessed using PPPASI), refractory to conventional line of therapy (for atleast 3 months) or had contraindications for the same were selected from our Dermatology OPD. Follow up was done monthly for 6 months.Results: 42% of the patients were good responders. 1 patient did not respond and 2 had progression of the disease. There was a decrease in the mean DLQI from a baseline of 25 to less than 15 by the end of 1st month and around 5 by the end of 6th month.60% of patients showed onset of response by the 1st month. 45% of the patients showed adverse effects, mostly being nausea followed by dizziness.Conclusions: From our study and those in the existing literature, it can be inferred that apremilast is a promising drug for palmoplantar as well as other forms of psoriasis, especially in patients with comorbidities or treatment refractory psoriasis.
背景:银屑病是一种免疫介导的炎症性丘疹-鳞状疾病,表现为慢性斑块、脓疱、红皮病、指甲、头皮、药物诱导、逆反应、点滴等。掌跖牛皮癣会导致严重的功能、美容和心理残疾。阿普雷米司特是一种相对较新的PDE-4抑制剂,不良反应可以忽略不计,血液监测最少。方法:这是一项基于机构的、非随机的、前瞻性的研究,为期3个月。42例中重度疾病患者(使用PPPASI评估),对常规治疗难以治愈(至少3个月)或有禁忌症,从我们的皮肤科OPD中选择。每月随访6个月。结果:42%的患者反应良好。1例无反应,2例病情进展。在第一个月结束时,平均DLQI从基线的25下降到15以下,在第6个月结束时下降到5左右。60%的患者在第1个月出现反应。45%的患者出现不良反应,主要是恶心,其次是头晕。结论:从我们的研究和现有文献可以推断,阿普雷米司特是一种很有前景的治疗掌跖及其他类型银屑病的药物,特别是对于合并合并症或治疗难治性银屑病的患者。
{"title":"An institution-based non-randomised prospective study to estimate the efficacy and adverse effect profile of apremilast for moderate to severe refractory palmoplantar psoriasis","authors":"N. Agrawal, Sabina Liangom Joanna Rongong, S. Halder, J. Barua, Param Satsangi, A. Halder, Prabal Samanta","doi":"10.18203/issn.2455-4529.intjresdermatol20231163","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231163","url":null,"abstract":"Background: Psoriasis is an immune-mediated inflammatory papulo-squamous disorder presenting as chronic plaque, pustular, erythrodermic, nail, scalp, drug induced, inverse, guttate etc. Palmoplantar psoriasis causes significant functional, cosmetic and psychological disability. Apremilast is a relatively newer drug being PDE-4 inhibitor, having negligible adverse effects with minimum blood monitoring.\u0000Methods: It is an institution-based, non-randomised, prospective study conducted over a period of 3 months. 42 patients of moderate to severe disease (assessed using PPPASI), refractory to conventional line of therapy (for atleast 3 months) or had contraindications for the same were selected from our Dermatology OPD. Follow up was done monthly for 6 months.\u0000Results: 42% of the patients were good responders. 1 patient did not respond and 2 had progression of the disease. There was a decrease in the mean DLQI from a baseline of 25 to less than 15 by the end of 1st month and around 5 by the end of 6th month.60% of patients showed onset of response by the 1st month. 45% of the patients showed adverse effects, mostly being nausea followed by dizziness.\u0000Conclusions: From our study and those in the existing literature, it can be inferred that apremilast is a promising drug for palmoplantar as well as other forms of psoriasis, especially in patients with comorbidities or treatment refractory psoriasis.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85816300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of atopic dermatitis in children in the city of Goma (Democratic Republic of Congo) 戈马市(刚果民主共和国)儿童特应性皮炎患病率
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231160
N. Pascaline, Ndayazi B. Désiré, Atadokpèdé F., Wembonyama O. Stanis
Background: Currently, atopic dermatitis is one of the most common chronic inflammatory dermatoses. However, studies concerning its prevalence in children are rare in the Democratic Republic of Congo (DRC). Thus, we proposed to determine the prevalence and sociodemographic factors associated with atopic dermatitis in children.Methods: We conducted a descriptive cross-sectional study over a 6-month period from June 1 to December 31, 2022. It focused on children aged 0 to 18 years who were brought to the dermatology services of the North Kivu Provincial Hospital (HPNK) for atopic dermatitis. Data were entered and analyzed using SPSS 20 and Epi info 3.5.3 software.Results: The hospital prevalence of atopic dermatitis in children aged 0-18 years was 12.4%. The 0 to 4 age group was the most affected with 54.4%. Males were the most represented (56.7%). The sex ratio M/F was 1.3. The majority of our patients were from the urban area (72.8%). Atopy (personal or familial) was found in 68.9% of patients and was dominated by asthma (23.9%) and allergic rhinitis (21.1%). The most common trigger was food (30.7%) followed by cosmetics (20.5%). Mean age of symptom onset was 7±2 months. The most represented clinical form was the common or vulgar form with 69.4% of cases. Atopic dermatitis was associated with sleep disorder in 77.8% of cases.Conclusions: The data presented in our study are also consistent with the literature which states that the prevalence of atopic dermatitis in children ranged from 10 to 20% and was higher in children under 5 years of age living in urban areas.
背景:特应性皮炎是目前最常见的慢性炎症性皮肤病之一。然而,关于其在刚果民主共和国(DRC)儿童患病率的研究很少。因此,我们建议确定与儿童特应性皮炎相关的患病率和社会人口因素。方法:我们在2022年6月1日至12月31日的6个月期间进行了描述性横断面研究。它的重点是被带到北基伍省医院皮肤科治疗特应性皮炎的0至18岁儿童。采用SPSS 20和Epi info 3.5.3软件进行数据录入和分析。结果:0 ~ 18岁儿童特应性皮炎的医院患病率为12.4%。0至4岁年龄组受影响最大,占54.4%。男性最多(56.7%)。性别比M/F为1.3。大多数患者来自城市地区(72.8%)。68.9%的患者存在特应性(个人或家族性),以哮喘(23.9%)和变应性鼻炎(21.1%)为主。最常见的诱因是食物(30.7%),其次是化妆品(20.5%)。平均发病年龄为7±2个月。临床表现以普通或庸俗形式最具代表性,占69.4%。77.8%的特应性皮炎患者伴有睡眠障碍。结论:我们研究中的数据也与文献一致,文献指出儿童特应性皮炎的患病率在10%到20%之间,并且在城市地区生活的5岁以下儿童中更高。
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引用次数: 0
Lupus vulgaris on face: a case report 面部寻常性狼疮1例报告
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231169
T. Nandakishore, Mrudula S., Linda Kongbam, Chai E. Buchem, Moirangthem Rokita, Anurag Srivastava
Lupus vulgaris is the most common form of cutaneous tuberculosis in adults. Starts either by re-infection or by lymphatic or hematogenous spread or by direct spread in individuals with moderate immunity and high degree of tuberculin sensitivity. Females affected 2-3 times more, constitute 1-2% of all extra-pulmonary TB. Common sites involved are face and neck. We reported a case lupus vulgaris in a 52 year old female patient.
寻常性狼疮是成人皮肤结核最常见的形式。在具有中等免疫力和高度结核菌素敏感性的个体中,通过再感染或淋巴或血液传播或直接传播开始。女性患者多2-3倍,占所有肺外结核的1-2%。常见的受累部位是面部和颈部。我们报告一例寻常性狼疮患者,年龄52岁。
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引用次数: 0
Folliculitis barbae caused by Staphylococcus lentus: a rarity with its dermoscopy features 由葡萄球菌引起的巴巴性毛囊炎:一种罕见的皮肤镜检查特征
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231168
B. Ankad, Sankappanavar V. Smitha, B. Nikam, A. Janagond
Dermoscopy of folliculitis is typified by white roundish globules around the hair follicles. Clinically, folliculitis mimics pseudo folliculitis which results from close shaving of beard hairs. Thus, management in both is entirely different. Dermoscopy of latter entity reveals buried hair at both ends. Here, authors described a case of folliculitis caused by Staphylococcus lentus.
毛囊炎的皮肤镜检查表现为毛囊周围有白色圆形小球体。在临床上,毛囊炎类似于由剃须引起的假性毛囊炎。因此,两者的管理是完全不同的。后者的皮肤镜检查显示两端埋有毛发。在这里,作者描述了一例由葡萄球菌引起的毛囊炎。
{"title":"Folliculitis barbae caused by Staphylococcus lentus: a rarity with its dermoscopy features","authors":"B. Ankad, Sankappanavar V. Smitha, B. Nikam, A. Janagond","doi":"10.18203/issn.2455-4529.intjresdermatol20231168","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231168","url":null,"abstract":"Dermoscopy of folliculitis is typified by white roundish globules around the hair follicles. Clinically, folliculitis mimics pseudo folliculitis which results from close shaving of beard hairs. Thus, management in both is entirely different. Dermoscopy of latter entity reveals buried hair at both ends. Here, authors described a case of folliculitis caused by Staphylococcus lentus.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79974203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pediatric case of resistant lichen planus pigmentosus treated with colchicine 秋水仙碱治疗顽固性色素扁平苔藓1例
Pub Date : 2023-04-27 DOI: 10.18203/issn.2455-4529.intjresdermatol20231164
Mehsas Zoubida, Sektaoui Soukaina, Boubnane Ibtissam, Znati Kaoutar, Senouci Karima, B. Laila
This is a case report of a 8-year-old child with lichen planus pigmentosus (LPP), a rare subtype of pediatric lichen planus, successfully treated with colchicine after failure of other therapeutic options. Colchicine was introduced at a dose of 0.5mg/day for 1 year with sun protection, resulting in cessation of the eruption's extension and decrease in hyperpigmentation. No adverse effects were observed. This case highlights the potential of colchicine as a treatment option for pediatric patients with LPP, although further studies with larger sample sizes and longer follow-up periods are needed to establish its safety and effectiveness.
这是一个8岁儿童的病例报告与扁平苔藓色素(LPP),一种罕见的亚型的儿童扁平苔藓,成功地用秋水仙碱治疗失败后,其他治疗方案。以0.5mg/天的剂量引入秋水仙碱,持续1年,并进行防晒,停止了皮疹的延伸,减少了色素沉着。未观察到不良反应。该病例强调了秋水仙碱作为小儿LPP患者的治疗选择的潜力,尽管需要进一步研究更大的样本量和更长的随访期来确定其安全性和有效性。
{"title":"A pediatric case of resistant lichen planus pigmentosus treated with colchicine","authors":"Mehsas Zoubida, Sektaoui Soukaina, Boubnane Ibtissam, Znati Kaoutar, Senouci Karima, B. Laila","doi":"10.18203/issn.2455-4529.intjresdermatol20231164","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231164","url":null,"abstract":"This is a case report of a 8-year-old child with lichen planus pigmentosus (LPP), a rare subtype of pediatric lichen planus, successfully treated with colchicine after failure of other therapeutic options. Colchicine was introduced at a dose of 0.5mg/day for 1 year with sun protection, resulting in cessation of the eruption's extension and decrease in hyperpigmentation. No adverse effects were observed. This case highlights the potential of colchicine as a treatment option for pediatric patients with LPP, although further studies with larger sample sizes and longer follow-up periods are needed to establish its safety and effectiveness.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86403807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Research in Dermatology
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