International journal of pediatric otorhinolaryngology最新文献

Effects of hearing aids on early prelingual auditory development in children with unilateral cochlear implantation: a linear mixed model for longitudinal data

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-24 DOI: 10.1016/j.ijporl.2025.112366

Mei Li , Wei-li Kong , Ning-ying Song

Introduction

We conducted a liner mixed model to explore the two-year early prelingual auditory development (EPLAD) of children with and without hearing aids (HAs) after unilateral cochlear implantation (CI) through a longitudinal study.

Methods

86 children with unilateral CI were divided into CI + HA (46) and CI (40) groups. Their EPLAD was assessed using the Infant Toddler Meaningful Auditory Integration Scale (IT/MAIS) before CI and at 1st, 3rd, 6th, 12th, 18th, and 24th months post-activation. A spline function described the EPLAD trajectory, and a best-fitting curve predicted IT/MAIS score changes over time. A linear mixed model analyzed the effects of HAs on EPLAD.

Results

CI + HA group had significantly higher IT/MAIS scores pre-op and up to 18 months post-CI (p < 0.01). There was no significant difference in the trajectory of EPLAD among different sex and age groups (p > 0.05). ITMAIS, sound detection and sound recognition trajectory of CI + HA group was significantly different from that of CI group (p < 0.01). We constructed a predictive score of IT/MAIS, sound detection and sound recognition over time with high accuracy (R = 0.99).

Conclusions

Most of studies about the effects of HAs on auditory development after CI merely conducted cross-sectional approach, which cannot reflect the real changes of individuals. For children with unilateral cochlear implant, wearing hearing aids in the contralateral ear can continuously improve EPLAD. The auditory development of individual is a dynamic process, and longitudinal study is more advantage to explore the real differences.

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引用次数: 0

Increased incidence of intracranial complications following pediatric sinogenic and otogenic infections in the post-COVID-19 Era: A systematic review and meta-analysis

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-22 DOI: 10.1016/j.ijporl.2025.112364

Pranav A. Patel , Asher T. Ripp , Shaun A. Nguyen , Alexander N. Duffy , Zachary M. Soler , Ramin Eskandari , David R. White , Rodney J. Schlosser

Background

This systematic-review and meta-analysis aims to evaluate and summarize the prevalence of pediatric intracranial complications following sinogenic or otogenic infections before and after the COVID-19 pandemic.

Methods

A literature search was performed using the PubMed, Scopus, and CINAHL databases to answer the question: In pediatric patients, was there an increase in the prevalence or severity of intracranial complications due to sinogenic or otogenic infections during and after the COVID-19 pandemic? Publications which included primary data on patients under the age of 18 years old, focusing on intracranial complications following otogenic and sinogenic infections were included.

Results

Of 1025 abstracts screened, 18 studies were included. There were no significant differences in age or sex between the two cohorts. Compared to the pre-COVID era, post-COVID infections were more likely to have neurologic complications upon presentation [11.4 % (1.6–53.0) vs 50.1 % (13.9–86.2), p < 0.01], cerebral venous sinus thrombosis (CVST) [14.1 % (10.6–18.2) vs 40.5 % (25.2–56.9), p < 0.01], intraparenchymal abscess [40.3 % (43.9–72.2) vs 54.9 % (25.2–87.1), p < 0.01], and meningitis [10.6 % (0.0–39.4) vs 40.2 % (13.4–70.8), p < 0.01]. Metronidazole use [38.7 % (31.8–46.0) vs 71.9 % (51.3–88.6), p < 0.01], craniectomy [16.1 % (1.3–42.8) vs 37.4 % (2.9–83.0), p = 0.02], and burr holes [16.8 % (11.5–23.3) vs 26.6 % (12.7–43.3), p = 0.02] were increased in the post-COVID cohort.

Conclusion

There are considerable differences in neurologic deficits, CVST, intraparenchymal abscesses, meningitis, and treatment modalities in pre- and post-COVID cohorts of children with intracranial complications of otorhinogenic origin. Further research is required to determine the underlying mechanism for these differences.

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引用次数: 0

The effect of chewing gum on postoperative pain in children undergoing tonsillectomy

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-21 DOI: 10.1016/j.ijporl.2025.112362

Sumbule Koksoy Vayısoglu , Harun Gur , Emine Oncu , Onur Ismi

Aims

The aim of this study was to investigate the impact of chewing gum on postoperative pain in pediatric patients undergoing tonsillectomy.

Material and methods

This study was conducted as a prospective, randomized controlled single-blind interventional study. Patients were randomized into two groups: control group which received a standard postoperative protocol and the chewing gum group which received the same postoperative protocol. Pain was evaluated by the Wong Baker scale.

Results

A total of 75 patients participated in the study, with 40 in the control group and 35 in the chewing gum group. The children's mean age and gender distribution were similar across the groups. According to the independent t-test results, there was a significant difference in pain levels between the chewing gum and control groups on all days. The pain levels in the chewing gum group were lower compared to the control group. Analgesic use was also lower in the gum group on all days (p < 0.05). Generalized linear mixed model analysis confirmed a significant independent effect of chewing gum on pain scores (p < 0.001), though the effect did not vary over time.

Conclusion

In conclusion, chewing gum may serve as a non-pharmacological method for postoperative pain management. In clinical practice, chewing gum could be a simple, low-cost, and easy-to-implement intervention.

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引用次数: 0

Randomized clinical trial of non-opioid pain medications after intracapsular adenotonsillectomy

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-21 DOI: 10.1016/j.ijporl.2025.112361

Nathan E. Lu, Amber D. Shaffer, Marina V. Rushchak, Raymond C. Maguire, Noel Jabbour, Allison B.J. Tobey, Jennifer L. McCoy , David H. Chi

Background

Our purpose was to determine if non-opioid pain control is safe and effective in the treatment of pain following intracapsular adenotonsillectomy (T&A).

Methods

A randomized, open-label, controlled trial of children ages 3–17 undergoing intracapsular T&A was conducted at a tertiary children's hospital April 2021–May 2023. Exclusions were concomitant procedures, Down syndrome, coagulopathy, craniofacial anomalies, and current opioid use. Participants were randomized to receive a prescription for oxycodone (opioid group) or not (non-opioid group). All patients received ibuprofen/acetaminophen. The primary outcome, average Wong-Baker FACES pain scores on post-operative days 0–14, was compared between groups using t-tests. The secondary outcome, emergency department (ED)/urgent care visits, was compared using logistic regression.

Results

Age (median 4, range 3–12) and gender (42/70, 60 % male) were similar in both groups. Pain diaries were returned by 21/36 (58 %) in the opioid group and 23/34 (68 %) of the non-opioid group. Average pain was not different between groups before (opioid: mean 3.2, 95 % CI 2.5–3.8; non-opioid: mean 3.3, 95 % CI 2.5–4.0) or after (opioid: mean: 1.1, 95 % CI 0.6–1.5; non-opioid mean: 1.0, 95 % CI 0.5–1.5) analgesics. Only 7/21 (33 %) of the opioid group took ≥1 dose of oxycodone; no patients in the non-opioid group requested an opioid prescription. There were no differences in peak pain scores, duration of analgesic use, ED/urgent care visits, or caregiver-reported symptoms or satisfaction between groups.

Conclusions

Pain scores were low compared with previous reports in children undergoing extracapsular T&A, suggesting non-opioid management is appropriate for pain control in this population.

{"title":"Randomized clinical trial of non-opioid pain medications after intracapsular adenotonsillectomy","authors":"Nathan E. Lu, Amber D. Shaffer, Marina V. Rushchak, Raymond C. Maguire, Noel Jabbour, Allison B.J. Tobey, Jennifer L. McCoy , David H. Chi","doi":"10.1016/j.ijporl.2025.112361","DOIUrl":"10.1016/j.ijporl.2025.112361","url":null,"abstract":"<div><h3>Background</h3><div>Our purpose was to determine if non-opioid pain control is safe and effective in the treatment of pain following intracapsular adenotonsillectomy (T&A).</div></div><div><h3>Methods</h3><div>A randomized, open-label, controlled trial of children ages 3–17 undergoing intracapsular T&A was conducted at a tertiary children's hospital April 2021–May 2023. Exclusions were concomitant procedures, Down syndrome, coagulopathy, craniofacial anomalies, and current opioid use. Participants were randomized to receive a prescription for oxycodone (opioid group) or not (non-opioid group). All patients received ibuprofen/acetaminophen. The primary outcome, average Wong-Baker FACES pain scores on post-operative days 0–14, was compared between groups using t-tests. The secondary outcome, emergency department (ED)/urgent care visits, was compared using logistic regression.</div></div><div><h3>Results</h3><div>Age (median 4, range 3–12) and gender (42/70, 60 % male) were similar in both groups. Pain diaries were returned by 21/36 (58 %) in the opioid group and 23/34 (68 %) of the non-opioid group. Average pain was not different between groups before (opioid: mean 3.2, 95 % CI 2.5–3.8; non-opioid: mean 3.3, 95 % CI 2.5–4.0) or after (opioid: mean: 1.1, 95 % CI 0.6–1.5; non-opioid mean: 1.0, 95 % CI 0.5–1.5) analgesics. Only 7/21 (33 %) of the opioid group took ≥1 dose of oxycodone; no patients in the non-opioid group requested an opioid prescription. There were no differences in peak pain scores, duration of analgesic use, ED/urgent care visits, or caregiver-reported symptoms or satisfaction between groups.</div></div><div><h3>Conclusions</h3><div>Pain scores were low compared with previous reports in children undergoing extracapsular T&A, suggesting non-opioid management is appropriate for pain control in this population.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112361"},"PeriodicalIF":1.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary aerodigestive team meetings for the management of complex airway patients

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-20 DOI: 10.1016/j.ijporl.2025.112360

Aryan Kalra , Rachel Blokland , Wendy Nicholls , Raimundo Garcia-Matte , Shyan Vijayasekaran

Objective

To examine the clinical profiles and management of patients discussed at our tertiary paediatric hospital's multidisciplinary aerodigestive team (ADT) meetings.

Method

Retrospective chart review of all patients discussed at the Perth Children's Hospital ADT meetings between December 2018 and July 2022. Patient demographics, clinical characteristics and meeting outcomes, including procedures, investigations and follow-up were reviewed.

Results

A total of 580 ADT meeting consults were recorded for 304 patients, with 116 patients requiring multiple consultations. The median age at time of consult was 2.74 years and 51.0 % of patients were male. The commonest aerodigestive tract disorders included tracheomalacia (20.7 %), laryngomalacia (20.7 %), laryngotracheal stenosis (13.2 %), gastro-oesophageal reflux (9.4 %) and tracheo-oesophageal fistula (9.4 %). A secondary diagnosis was seen in 45.5 % of patients, most commonly Trisomy 21 (10.2 %), Robin Sequence (4.9 %) and Cerebral Palsy (3.0 %). Children with secondary diagnoses (P < 0.01), tracheostomy dependence (P < 0.01), upper airway disorders (P < 0.01) and oesophageal disorders (P < 0.01) were more likely to require multiple ADT consults. Further investigations were ordered after 25.9 % of consults, most commonly polysomnography (14.9 %) and video fluoroscopic swallowing studies (6.1 %). A total of 742 procedures were performed to diagnose and/or treat aerodigestive disease. The commonest diagnostic procedures were microlaryngoscopy and bronchoscopy (46.9 %), upper gastrointestinal endoscopy (7.8 %) and sleep nasendoscopy (6.7 %). The commonest interventional surgical procedures were adenoidectomy (12.4 %), balloon dilation of laryngotracheal stenosis (9.4 %), steroid injection to laryngeal scar or granulation tissue (8.4 %) and supraglottoplasty (6.7 %).

Conclusion

The aerodigestive program utilises a multidisciplinary approach to manage a medically complex cohort of patients. This study presents a large sample of patients from an Otolaryngology-led aerodigestive program in Australia and is intended to guide development of aerodigestive programs across the world in various clinical contexts.

方法回顾2018年12月至2022年7月期间在珀斯儿童医院ADT会议上讨论的所有患者的病历。结果共记录了304名患者的580次ADT会议会诊，其中116名患者需要多次会诊。就诊时的中位年龄为 2.74 岁，51.0% 的患者为男性。最常见的气道疾病包括气管畸形（20.7%）、喉畸形（20.7%）、喉气管狭窄（13.2%）、胃食管反流（9.4%）和气管食管瘘（9.4%）。45.5%的患者有第二诊断，最常见的是 21 三体综合征（10.2%）、罗宾序列（4.9%）和脑瘫（3.0%）。有二次诊断（P <0.01）、气管造口依赖（P <0.01）、上气道疾病（P <0.01）和食道疾病（P <0.01）的儿童更有可能需要多次 ADT 会诊。25.9%的会诊后需要进行进一步检查，其中最常见的是多导睡眠图（14.9%）和视频透视吞咽检查（6.1%）。为诊断和/或治疗气道疾病，共进行了 742 次手术。最常见的诊断程序是显微喉镜和支气管镜检查（46.9%）、上消化道内窥镜检查（7.8%）和睡眠鼻内窥镜检查（6.7%）。最常见的介入性外科手术是腺样体切除术（12.4%）、喉气管狭窄球囊扩张术（9.4%）、喉部瘢痕或肉芽组织类固醇注射（8.4%）和声门上成形术（6.7%）。本研究介绍了澳大利亚由耳鼻喉科主导的气道消化项目中的大量患者样本，旨在为世界各地不同临床环境下气道消化项目的发展提供指导。

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引用次数: 0

Application of the odor Stick identification test for Japanese (OSIT-J) in preschool Children: A study on odor identification and developmental correlations 日语气味棒识别测试（OSIT-J）在学龄前儿童中的应用：气味识别和发育相关性研究

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-18 DOI: 10.1016/j.ijporl.2025.112353

Yuna Inada , Masaharu Kato

This study aimed to evaluate the applicability of the Odor Stick Identification Test for the Japanese (OSIT-J) among preschool children aged 4–6. The study sought to determine whether the OSIT-J, originally designed for adults, can effectively assess olfactory identification in young children, and explore its correlation with developmental factors. This observational study included 84 preschool children who took the OSIT-J and vocabulary tests. A developmental and daily contact experience questionnaire was administered to the parents. The OSIT-J included 12 odors that Japanese adults were familiar with, while children were asked to identify these odors using four alternatives. The vocabulary test assessed children's understanding of the terms used in the OSIT-J. Children's ability to identify odors was found to improve with age, particularly among girls. Significant correlations were observed between OSIT-J and developmental test scores (total, social, and language) and vocabulary test scores. However, no correlation was observed between daily contact experience and social communication questionnaire scores. The children easily identified certain odors, such as curry and Japanese orange. The OSIT-J could serve as a promising tool to assess the olfactory identification abilities of preschool children. The study highlights the role of vocabulary and social interactions in odor identification. This indicates the utility of also considering social and language development when difficulties with odor identification are observed in the preschool years. Future research should validate the effectiveness of this test in detecting olfactory disorders and explore its use in diverse populations.

{"title":"Application of the odor Stick identification test for Japanese (OSIT-J) in preschool Children: A study on odor identification and developmental correlations","authors":"Yuna Inada , Masaharu Kato","doi":"10.1016/j.ijporl.2025.112353","DOIUrl":"10.1016/j.ijporl.2025.112353","url":null,"abstract":"<div><div>This study aimed to evaluate the applicability of the Odor Stick Identification Test for the Japanese (OSIT-J) among preschool children aged 4–6. The study sought to determine whether the OSIT-J, originally designed for adults, can effectively assess olfactory identification in young children, and explore its correlation with developmental factors. This observational study included 84 preschool children who took the OSIT-J and vocabulary tests. A developmental and daily contact experience questionnaire was administered to the parents. The OSIT-J included 12 odors that Japanese adults were familiar with, while children were asked to identify these odors using four alternatives. The vocabulary test assessed children's understanding of the terms used in the OSIT-J. Children's ability to identify odors was found to improve with age, particularly among girls. Significant correlations were observed between OSIT-J and developmental test scores (total, social, and language) and vocabulary test scores. However, no correlation was observed between daily contact experience and social communication questionnaire scores. The children easily identified certain odors, such as curry and Japanese orange. The OSIT-J could serve as a promising tool to assess the olfactory identification abilities of preschool children. The study highlights the role of vocabulary and social interactions in odor identification. This indicates the utility of also considering social and language development when difficulties with odor identification are observed in the preschool years. Future research should validate the effectiveness of this test in detecting olfactory disorders and explore its use in diverse populations.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112353"},"PeriodicalIF":1.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated oxidative stress in pediatric chronic rhinosinusitis

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-17 DOI: 10.1016/j.ijporl.2025.112349

Nilay Çalışkan , Fatih Dilek , Eray Metin Güler , Remzi Doğan , Abdurrahim Koçyiğit , Emin Özkaya

引用次数: 0

Early life exposures and risk of salivary gland diseases in childhood: A 28-year nationwide cohort study

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-16 DOI: 10.1016/j.ijporl.2025.112354

Christina Resende de Paiva , Kathrine Kold Sørensen , Stine Attrup Schrøder , Jakob Foghsgaard , Christian Torp-Pedersen , Michael F. Howitz

Background

Limited research has been conducted on salivary gland diseases in childhood, including disease etiology and associated risk factors. This study examines how early-life exposures influence the rate of salivary gland disease.

Objective

To access the association between early-life exposures and salivary gland disease in childhood as well as to examine sex and age distribution and time trends.

Methods

The study was a nested case control study in children, matching five controls to each case between 1994 and 2022. We assessed the association between seven early-life exposures and three categories of salivary gland diseases: juvenile recurrent parotitis (JRP), salivary stones and salivary retention cysts. Conditional logistic regression was used to estimate hazard ratios (HRs) for each association.

Results

We identified 4778 cases and 23,890 controls: 2637 cases of JRP, 765 cases of salivary stones and 1376 cases of salivary retention cysts. Preterm birth (HR 1.24, 95 % CI 1.05; 1.47), low birth weight for gestational age (HR 1.38, 95 % CI 1.13; 1.69), young maternal age (HR 1.53, 95 % CI 1.20; 1.94) and low income (HR 1.27, 95 % CI 1.11; 1.45) were all positively associated with JRP. Maternal overweight (HR 0.85, 95 % CI 0.74; 0.97) had a negative association with JRP. No early-life exposure was significantly associated with salivary stones or retention cysts.

Conclusion

Children born preterm, small for gestational age, by young mothers, and with low household income, had an increased rate of developing nonspecific salivary gland disease, likely juvenile recurrent parotitis. In contrast, such associations were not identified for any other salivary gland disease.

{"title":"Early life exposures and risk of salivary gland diseases in childhood: A 28-year nationwide cohort study","authors":"Christina Resende de Paiva , Kathrine Kold Sørensen , Stine Attrup Schrøder , Jakob Foghsgaard , Christian Torp-Pedersen , Michael F. Howitz","doi":"10.1016/j.ijporl.2025.112354","DOIUrl":"10.1016/j.ijporl.2025.112354","url":null,"abstract":"<div><h3>Background</h3><div>Limited research has been conducted on salivary gland diseases in childhood, including disease etiology and associated risk factors. This study examines how early-life exposures influence the rate of salivary gland disease.</div></div><div><h3>Objective</h3><div>To access the association between early-life exposures and salivary gland disease in childhood as well as to examine sex and age distribution and time trends.</div></div><div><h3>Methods</h3><div>The study was a nested case control study in children, matching five controls to each case between 1994 and 2022. We assessed the association between seven early-life exposures and three categories of salivary gland diseases: juvenile recurrent parotitis (JRP), salivary stones and salivary retention cysts. Conditional logistic regression was used to estimate hazard ratios (HRs) for each association.</div></div><div><h3>Results</h3><div>We identified 4778 cases and 23,890 controls: 2637 cases of JRP, 765 cases of salivary stones and 1376 cases of salivary retention cysts. Preterm birth (HR 1.24, 95 % CI 1.05; 1.47), low birth weight for gestational age (HR 1.38, 95 % CI 1.13; 1.69), young maternal age (HR 1.53, 95 % CI 1.20; 1.94) and low income (HR 1.27, 95 % CI 1.11; 1.45) were all positively associated with JRP. Maternal overweight (HR 0.85, 95 % CI 0.74; 0.97) had a negative association with JRP. No early-life exposure was significantly associated with salivary stones or retention cysts.</div></div><div><h3>Conclusion</h3><div>Children born preterm, small for gestational age, by young mothers, and with low household income, had an increased rate of developing nonspecific salivary gland disease, likely juvenile recurrent parotitis. In contrast, such associations were not identified for any other salivary gland disease.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112354"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IQGAP3 deficiency leads to non-syndromic hearing loss via inhibition of CDC42 enzyme activity

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-15 DOI: 10.1016/j.ijporl.2025.112358

Yu Li , Haipeng Dong , Xiaoya Wang , Fuping Qian , Junzhe Huang , Chao Hou , Hao Qin , Yuehong Liu , Shuang Feng , Wenlong Liu , Shengli Gao , Changzhi Sun , Yanqiu Chen , Renzhong Luo , Chunfu Dai , Ru Zhang , Hongyan Liu , Luping Zhang , Yan Zheng , Na Li , Hao Hu

Background

Genetic factors are important causes of congenital hearing loss. To better understand hereditary hearing loss, we performed in-depth clinical and molecular analysis of families with congenital hearing loss and a new disease-related gene, IQGAP3, was identified in this process. This gene encodes a protein that belongs to the IQGAP family which is well known as a GTPase-activating protein involved in various cellular functions. However, there is no research on the relationship between IQGAP3 and the auditory system.

Method

This study was conducted at Guangzhou Women and Children's Medical Center and Nantong University from 2019 to 2023 to confirm the relationship between defective IQGAP3 and hearing loss, and further explore the underlying molecular mechanism. We constructed the iqgap3 knockdown zebrafish model, primary mouse inner progenitor cell model and IQGAP3-knockout HEK293T cell line for this research.

Result

We found that IQGAP3 deficiency led to abnormal development of the auditory system and impaired auditory function in zebrafish. In vitro studies showed that loss of this gene's function resulted in a 40.29 % reduction in EdU-positive cells and a 44.25 % decrease in Ki67-positive cells in mouse inner ear progenitor cells, indicating reduced proliferation. This can be linked with inhibition of CDC42 enzymatic activity and the blockade of the Wnt-catenin pathway.

Conclusion

We identified IQGAP3 as a novel potential causative gene in hereditary hearing loss. Our findings provide important insights into the molecular basis of hereditary hearing loss.

{"title":"IQGAP3 deficiency leads to non-syndromic hearing loss via inhibition of CDC42 enzyme activity","authors":"Yu Li , Haipeng Dong , Xiaoya Wang , Fuping Qian , Junzhe Huang , Chao Hou , Hao Qin , Yuehong Liu , Shuang Feng , Wenlong Liu , Shengli Gao , Changzhi Sun , Yanqiu Chen , Renzhong Luo , Chunfu Dai , Ru Zhang , Hongyan Liu , Luping Zhang , Yan Zheng , Na Li , Hao Hu","doi":"10.1016/j.ijporl.2025.112358","DOIUrl":"10.1016/j.ijporl.2025.112358","url":null,"abstract":"<div><h3>Background</h3><div>Genetic factors are important causes of congenital hearing loss. To better understand hereditary hearing loss, we performed in-depth clinical and molecular analysis of families with congenital hearing loss and a new disease-related gene, <em>IQGAP3</em>, was identified in this process. This gene encodes a protein that belongs to the IQGAP family which is well known as a GTPase-activating protein involved in various cellular functions. However, there is no research on the relationship between <em>IQGAP3</em> and the auditory system.</div></div><div><h3>Method</h3><div>This study was conducted at Guangzhou Women and Children's Medical Center and Nantong University from 2019 to 2023 to confirm the relationship between defective IQGAP3 and hearing loss, and further explore the underlying molecular mechanism. We constructed the <em>iqgap3</em> knockdown zebrafish model, primary mouse inner progenitor cell model and <em>IQGAP3</em>-knockout HEK293T cell line for this research.</div></div><div><h3>Result</h3><div>We found that <em>IQGAP3</em> deficiency led to abnormal development of the auditory system and impaired auditory function in zebrafish. In vitro studies showed that loss of this gene's function resulted in a 40.29 % reduction in EdU-positive cells and a 44.25 % decrease in Ki67-positive cells in mouse inner ear progenitor cells, indicating reduced proliferation. This can be linked with inhibition of CDC42 enzymatic activity and the blockade of the Wnt-catenin pathway.</div></div><div><h3>Conclusion</h3><div>We identified <em>IQGAP3</em> as a novel potential causative gene in hereditary hearing loss. Our findings provide important insights into the molecular basis of hereditary hearing loss.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112358"},"PeriodicalIF":1.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical utility of an optical coherence tomography middle ear scope: Interim results of the modification of antibiotic treatment intervention in children (OTO-MATIC) pragmatic cluster randomized controlled trial (RCT)

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-04-14 DOI: 10.1016/j.ijporl.2025.112356

April Zambelli-Weiner , Brian H. Nathanson , Frank Calcagno , John Ansley , Karina Vattana , Bonnie Burnette-Vick

Objectives

To evaluate the impact of a novel Optical Coherence Tomography (OCT) otoscope on the number of antibiotic prescriptions written for pediatric patients presenting to a primary care office with ear-related complaints, compared to the Standard of Care (SOC), a traditional otoscope.

Study Design

Planned interim analysis of the One Year OTO-MATIC Randomized Controlled Trial (RCT), multicenter, real-world effectiveness study. Pediatric patients presenting with ear-related complaints were seen by a provider previously randomized into the SOC or Intervention arm. The primary outcome was reduced antibiotic prescriptions (clinician rate and number of rounds per patient) for Intervention participants compared to the SOC participants. Secondary outcomes included changes in treatment recommendations at Baseline Visit (BV), including singular versus multimodal treatments, and referrals to an otolaryngologist, specifically.

Results

At the time of the interim database lock, there were 248 participants enrolled across four sites and 16 providers who had completed the BV. Our results demonstrate that the OCT intervention reduced the odds of antibiotic prescribing by 50 % compared to the SOC (OR = 0.50, 95 % CI: 0.45–0.56). Additionally, providers in the Intervention group were significantly more likely to initiate a single therapeutic modality versus multiple, often disparate modalities (91.6 % vs. 73.8 %, p < 0.001, respectively).

Conclusions

Interim results suggest the OCT imaging technology (OtoSight, PhotoniCare) improves antibiotic stewardship with clinicians in the OCT arm having a reduced likelihood of prescribing antibiotics compared to the SOC arm. Overall, changes in provider prescribing patterns and therapeutic management of the patient are consistent with increased diagnostic certainty.

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引用次数: 0