International journal of pediatric otorhinolaryngology最新文献

{"title":"Autoimmune etiologies in pediatric recurrent parotitis: A retrospective analysis of patients referred to rheumatology","authors":"Maya Guhan , Yiressy Pina , Elton Lambert , Maria Pereira , Marietta De Guzman","doi":"10.1016/j.ijporl.2024.112192","DOIUrl":"10.1016/j.ijporl.2024.112192","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"188 ","pages":"Article 112192"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vomer-to-nasopharyngeal widths and post-adenoidectomy outcomes in children: A prospective blinded study","authors":"Roee Noy ,&nbsp;Jacob T. Cohen ,&nbsp;Arie Gordin","doi":"10.1016/j.ijporl.2024.112193","DOIUrl":"10.1016/j.ijporl.2024.112193","url":null,"abstract":"<div><h3>Objectives</h3><div>The vomer is an essential component of the nasopharynx. Although variations in vomer width(VW) and nasopharyngeal width(NW) can be observed, their clinical significance on post-adenoidectomy outcomes in children with sleep-disordered breathing and obstructive sleep apnea(SDB–OSA) remains uncertain. The primary outcome was to investigate the association between VW and post-adenoidectomy clinical improvement. Secondary outcomes were to investigate the variability and interplay between VW and NW.</div></div><div><h3>Methods</h3><div>This prospective, blinded cohort study was conducted at a tertiary hospital between 6/2022 and 7/2023. Children who underwent adenoidectomy for SDB–OSA were included. VW and NW were measured using a transoral endoscope. A calibrated ruler was positioned at the inferior aspect of the vomer for direct visualization, and the NW was calculated as the distance between the medial edges of the torus tubarius. Clinical improvement was collected using the OSA-18 survey.</div></div><div><h3>Results</h3><div>Of the 29 children (mean age:3.5 years, IQR: 2–4, 16[55 %] males), 26(89.6 %) showed a clinical improvement 1-month post-adenoidectomy (ΔOSA-18 score: 24.6,95 % confidence interval: 31–(-14),p = 0.001). The mean VW was 3.88 mm (IQR: 3–4), and the mean NW was 13.76 mm (IQR:13–14). In the univariable analysis, clinical improvement was associated with age &lt;3 years(p = 0.05), non-obese children(p = 0.01), large adenoids(p = 0.01), preoperative OSA-18 score&gt;60(p = 0.05), and lower VW/NW(p = 0.013). The odds ratio for clinical improvement was decreased by 1.08 for each 0.01 increase in VW/NW (95%CI:1.05–1.11,p = 0.01).</div></div><div><h3>Conclusions</h3><div>Lower VW/NW were associated with better clinical outcome 1-month post-adenoidectomy. Further randomized, prospective studies are needed to validate these findings and and explore whether interventions in this area could serve as a potential therapeutic target.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"188 ","pages":"Article 112193"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of endoscopic sinus surgery in patients under six years old","authors":"Harrington Chloe,&nbsp;Ibrahim Ibrahim,&nbsp;Hengameh Bezadpour,&nbsp;Espinel Alexandra,&nbsp;Zalzal Habib G","doi":"10.1016/j.ijporl.2024.112213","DOIUrl":"10.1016/j.ijporl.2024.112213","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine safety and efficacy of very young patients under the age of six who underwent endoscopic sinus surgery (ESS) at our institution for the indications of either complicated acute rhinosinusitis (ARS) or chronic rhinosinusitis (CRS).</div></div><div><h3>Methods</h3><div>Retrospective cohort review of patients under six years old who underwent ESS for sinonasal pathology between 2016 and 2023 at a freestanding pediatric hospital. Age, sex, weight, diagnosis, laterality of disease, medications, types and number of surgical interventions, usage of image guidance, and outcomes were obtained from the medical record.</div></div><div><h3>Results</h3><div>A total of 25 patients met inclusion criteria (range 1 month–5 years). Eighteen of the patients underwent surgery for an indication of complicated ARS and 7 patients underwent surgery for CRS. Ages were separated into three categories, &lt;1 year (n = 1), 1–3 year (n = 3), 3–6 year (n = 21). Chi squared testing between these three age groups revealed no significant differences in revision rates. There were 5 children who required revision surgery, 3 of which had CRS. Ages of the children who required revision ranged from 2 to 4 years old. There was only one surgical complication observed.</div></div><div><h3>Conclusions</h3><div>Endoscopic sinus surgery has been increasingly considered safe in pediatric otolaryngology, however, our database in particular focuses on a very young subset of these patients in which there were very few (one) morbidities and no mortalities. Further study of this population should be continued to determine long term outcomes; however, it should be considered safe in acute situations.</div></div><div><h3>Level of evidence</h3><div>Level 4.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"188 ","pages":"Article 112213"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Factors influencing auditory brainstem response changes in infants\" [Int. J. Pediatr. Otorhinolaryngol. Volume185/issue details, cover date, 112094].","authors":"Tomoko Esaki, Tadao Yoshida, Masumi Kobayashi, Kyoko Morimoto, Chisa Shibata, Michihiko Sone","doi":"10.1016/j.ijporl.2024.112206","DOIUrl":"https://doi.org/10.1016/j.ijporl.2024.112206","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":" ","pages":"112206"},"PeriodicalIF":1.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A review of the importance of top-down processing assessment in auditory processing disorder\" [Int. J. Pediatr. Otorhinolaryngol. 186, (November 2024), 112128].","authors":"Bahareh Khavarghazalani, Zahra Hosseini Dastgerdi, Morteza Hamidi Nahrani, Maryam Emadi","doi":"10.1016/j.ijporl.2024.112202","DOIUrl":"https://doi.org/10.1016/j.ijporl.2024.112202","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":" ","pages":"112202"},"PeriodicalIF":1.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental tracheostomy decannulation: Risk factors and complications in pediatric patients using the NSQIP-P database","authors":"Jacob Heninger ,&nbsp;Arkadeep Ghosh ,&nbsp;Matthew Rowland ,&nbsp;Inbal Hazkani ,&nbsp;Taher Valika ,&nbsp;Eric C. Cheon","doi":"10.1016/j.ijporl.2024.112174","DOIUrl":"10.1016/j.ijporl.2024.112174","url":null,"abstract":"<div><h3>Background</h3><div>Accidental tracheostomy decannulation (ATD) is a life-threatening event in pediatric patients. The factors associated with ATD in children are largely unknown. Utilizing the National Surgical Quality Improvement Pediatric (NSQIP-P) dataset, we sought to identify the incidence of ATD and associated factors.</div></div><div><h3>Methods</h3><div>Patients who underwent surgery at continuously enrolled American College of Surgeons NSQIP-P hospitals from January 1, 2012, to December 31, 2021, were included. Those who underwent a tracheostomy (CPT 31600 or 31601) as a primary or concurrent procedure were analyzed. ATD was defined by the NSQIP-P REINTUB variable. Multivariable logistic regression analysis and propensity score matching were performed to identify independent associations between demographic variables, relevant comorbidities, intraoperative factors, and ATD. Multivariable regression analyses were performed to identify any association between ATD and unplanned reoperation, pneumonia, extended length of stay, and death in 30 days in both pre-matched and matched cohorts.</div></div><div><h3>Results</h3><div>A total of 5229 patients undergoing tracheostomy were included in the final analysis for the pre-matched cohort. ATD occurred in 93 (1.8 %) patients, with 42 % (n = 39) of these cases occurring within the first two postoperative days. In the matched cohort, female gender (<em>P</em> = 0.002) and structural pulmonary/airway abnormality (<em>P</em> = 0.016) were independently associated with ATD. Additionally, ATD was associated with unplanned reoperation (<em>P</em> &lt; 0.001) and pneumonia (<em>P</em> = 0.024). The pre-matched cohort showed consistent results with the matched cohort.</div></div><div><h3>Discussion</h3><div>Accidental decannulation is a serious complication following pediatric tracheostomy. By identifying patients at higher risk for ATD and the timing of its occurrence, providers can employ measures targeting these patients during their highest risk period. The sequelae associated with ATD further emphasize the importance of preventing this complication.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112174"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holiday letter 2024","authors":"Joseph E. Kerschner MD (Editor-in-Chief)","doi":"10.1016/j.ijporl.2024.112178","DOIUrl":"10.1016/j.ijporl.2024.112178","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112178"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent trends in pediatric maxillary frenum classification","authors":"Alexandra F. Corbin ,&nbsp;Lauren A. DiNardo ,&nbsp;Deepthi S. Akella ,&nbsp;Alison C. Ma ,&nbsp;Douglas P. Nanu ,&nbsp;Francesca C. Viola ,&nbsp;Michele M. Carr","doi":"10.1016/j.ijporl.2024.112173","DOIUrl":"10.1016/j.ijporl.2024.112173","url":null,"abstract":"<div><h3>Objective</h3><div>To describe maxillary frenum Kotlow scores in a pediatric population.</div></div><div><h3>Methods</h3><div>A retrospective chart review was performed for children ages 0–19 years old seen at a pediatric otolaryngology clinic by one surgeon from March–December 2022. Inclusion criteria required a recorded maxillary frenum Kotlow score. Data collected included age, gender, race/ethnicity, Kotlow score, and history of maxillary frenotomy.</div></div><div><h3>Results</h3><div>570 children were included, comprising 267 (46.8%) females, 302 (53.0%) males, and 1 (0.2%) transgender male. Mean age was 5.0 years (95% CI 4.6–5.4). 24 patients (4.2%) had a history of maxillary frenotomy, while 546 (95.8%) did not. Among those with no maxillary frenotomy history, 21 (3.8%) had a Kotlow 1, 127 (23.3%) Kotlow 2, 261 (47.8%) Kotlow 3, and 137 (25.1%) Kotlow 4. Kotlow scores decreased with age. For children with prior maxillary frenotomy, class 1 frenum mean age was 6.9 years, and class 4 was 0.6 years (P=.008). For those without a maxillary frenotomy history, class 1 frenum mean age was 8.7 years, and class 4 was 1.3 years (P&lt;.001). No association was found between maxillary frenotomy history and lower Kotlow scores.</div></div><div><h3>Conclusion</h3><div>Nearly half of children have a Kotlow 3 maxillary frenum. Kotlow scores decrease as children age, reflecting elevated frenum insertion as the alveolar ridge develops. Otolaryngologists may find this data valuable when considering maxillary frenotomy in children.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112173"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative CRISPR/Cas9 mouse model of human isolated microtia indicates the potential contribution of CNVs near HMX1 gene","authors":"Wenshan Xing ,&nbsp;Jiao Zhang ,&nbsp;Tun Liu ,&nbsp;Yue Wang ,&nbsp;Jin Qian ,&nbsp;Bingqing Wang ,&nbsp;Yongbiao Zhang ([email protected]) ,&nbsp;Qingguo Zhang","doi":"10.1016/j.ijporl.2024.112141","DOIUrl":"10.1016/j.ijporl.2024.112141","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Microtia is a prevalent congenital malformation, the precise etiology and pathogenesis of which remain elusive. Mutations in the non-coding region of the &lt;em&gt;HMX1&lt;/em&gt; gene have been implicated in isolated cases of microtia, emerging as a significant focus of contemporary research. Several pathogenic copy number variations (CNVs) proximal to the &lt;em&gt;HMX1&lt;/em&gt; gene have been documented in wild animal populations, whereas only a single large segmental duplication in this region has been identified in humans. However, the absence of a gene-edited animal model has impeded the investigation of the unclear gene function associated with &lt;em&gt;HMX1&lt;/em&gt; mutations in human isolated microtia. In this study, we sought to precisely identify the pathogenic mutation by analyzing three pedigrees alongside population controls. Subsequently, our objective was to develop a CRISPR/Cas9 gene-edited mouse model to elucidate the functional implications of the identified mutation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Genomic DNA was collected from 32 affected individuals across three pedigrees, as well as from 2000 control subjects. Comprehensive genomic analyses, including genome-wide linkage analysis, targeted capture, second-generation sequencing, and copy number analysis, were conducted to identify potential mutations associated with congenital auricle malformation. CRISPR/Cas9 gene-edited murine models were generated in response to the identified mutation. The auricular phenotypes of these gene-edited mice were systematically monitored. Small-animal Micro-CT scanning was employed to identify potential craniofacial or skeletal abnormalities. Furthermore, the expression of the &lt;em&gt;HMX1&lt;/em&gt; gene in the PA2 region of mouse embryos was quantified using RT-qPCR.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A co-segregated 600 base pair duplication located on chromosome 4 (chr4:8701900-8702500, hg19) was identified in affected individuals across three pedigrees, but was absent in healthy controls. Two types of CRISPR/Cas9 gene-edited mice were subsequently generated. The knock-in (KI) mouse model was engineered by inserting one copy of the duplicated sequence directly adjacent to the mutated site, whereas the knockout (KO) mouse model was created by excising the mutation sequence. The phenotypes of different group of CRISPR/Cas9 gene-edited mice demonstrated distinct auricular deformities. Furthermore, an increase in the copy number of the mutated sequence was associated with elevated expression levels of &lt;em&gt;HMX1&lt;/em&gt; in the gene-edited mouse model.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In this study, we further narrowed down and identified a 600 base pair copy number variation (CNV) located at chr4:8701900-8702500 (hg19), which is implicated in human bilateral, isolated microtia. Utilizing CRISPR/Cas9 technology, we developed novel mouse models harboring the identified mutation. These models serve as a robust platform for the comprehensive invest","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112141"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of endoscopic sinus surgery in pediatric patients with sinogenic intracranial infection: A systematic review and meta-analysis","authors":"Elysia Grose ,&nbsp;Jenny B. Xiao ,&nbsp;Evan Fang ,&nbsp;Brigitte Routhier-Chevrier ,&nbsp;Jennifer M. Siu ,&nbsp;Nikolaus E. Wolter","doi":"10.1016/j.ijporl.2024.112176","DOIUrl":"10.1016/j.ijporl.2024.112176","url":null,"abstract":"<div><h3>Objective</h3><div>This review aims to elucidate the role of endoscopic sinus surgery (ESS) on the outcomes of pediatric patients with sinogenic intracranial infections.</div></div><div><h3>Methods</h3><div>MEDLINE, Embase, and the Cochrane library were searched for articles that described the outcomes in pediatric patients who had intracranial complications of acute rhinosinusitis (ARS) and underwent ESS with or without open neurosurgical approaches (ONA) or external sinus approaches (ESA). Primary outcomes of interest include mortality, revision surgery, length of stay and neurological sequelae. Random effects meta-analysis was performed.</div></div><div><h3>Results</h3><div>Forty-eight articles met the final eligibility criteria, totaling 710 pediatric patients and 905 intracranial complications. The most common complications were subdural empyema (n = 261, 29 %), epidural abscess (n = 213, 24 %), and Pott's Puffy tumor (PPT) (n = 95, 10 %). When comparing patients who underwent ESS (alone or combined with ONA) to those who underwent ONA only, there was a decreased risk of revision surgery (RR = 0.66, 95 % CI = 0.38–1.12 and RR = 0.63, 95 % CI = 0.36–1.09, respectively) and decreased risk of neurological sequelae (RR = 0.65, 95 % CI = 0.15–2.74 and RR = 0.50, 95 % CI = 0.20–1.26, respectively), however these differences were not statistically significant. When patients who underwent combined intervention were compared to ESS only, the risk of revision surgery (RR = 1.04, 95 % CI = 0.62–1.72) and neurological sequelae (RR = 0.99, 95 % CI = 0.37–2.64) were similar. Risk of mortality was minimal and similar across all interventions.</div></div><div><h3>Conclusion</h3><div>The current study including primarily small retrospective studies found no statistically significant differences between children who received ESS alone, ESS with ONA or ONA alone, on mortality, revision surgery, length of stay and neurological sequelae. Although ESS may be beneficial for managing certain pediatric sinogenic intracranial infections, its true effectiveness is difficult to determine due to the variability in the types of intracranial complications and the inconsistent extent of ESS procedures reported in the literature.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112176"},"PeriodicalIF":1.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}