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Corrigendum to “Application of the Das-Naglieri Cognitive Assessment System in children with sleep-disordered breathing” [Int. J. Pediatr. Otorhinolaryngol. 198 (2025) 112599] “Das-Naglieri认知评估系统在睡眠呼吸障碍儿童中的应用”的勘误表[j]。j . Pediatr。耳鼻咽喉学报,1998,11(3):1125 - 1125。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.ijporl.2025.112642
Liqiang Yang, Jinhong Zeng, Shuyao Qiu, Jianwen Zhong, Jinhong Huang, Min Zhi, Dabo Liu
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引用次数: 0
Pediatric vertigo: Age-Specific profiles and modifiable biomarkers in a case-control study 小儿眩晕:一项病例对照研究中的年龄特异性特征和可修改的生物标志物。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.ijporl.2025.112658
Ünal Akça , Gülfer Akça
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引用次数: 0
Behavioral and socio-emotional profiles in early-school-age children with cochlear implants versus normal-hearing peers 植入人工耳蜗的学龄前儿童与听力正常的同龄人的行为和社会情感特征。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-27 DOI: 10.1016/j.ijporl.2025.112653
Yuşa Başoğlu , İlayda Başoğlu , Gül Ölçek

Objective

To compare teacher-reported socio-emotional and behavioral functioning in early-school-age children with cochlear implants (CI) versus normal-hearing (NH) peers using the Child Behavior Assessment Scale (CBAS), and to test whether group differences persist after adjustment for socioeconomic factors.

Methods

In this cross-sectional study, 80 children aged 5–6 years were enrolled (CI = 40; NH = 40). Teachers completed CBAS subscales (Adjustment, Social Anxiety, Rule-breaking Behaviors) and total score. Between-group comparisons used Mann–Whitney U tests. ANCOVA on CBAS total adjusted for maternal education, paternal education, and household income. Exploratory correlations within the CI group examined age and clinical durations.

Results

Compared with NH peers, the CI group showed lower Adjustment (mean ± SD: 61.45 ± 15.46 vs 80.95 ± 6.56; p < .001) and higher Social Anxiety (64.20 ± 13.27 vs 34.28 ± 7.02; p < .001) and Rule-breaking Behaviors (113.33 ± 26.77 vs 61.08 ± 15.98; p < .001). CBAS total was higher in the CI group (238.98 ± 48.22) than NH (176.30 ± 17.10; p < .001). In ANCOVA, the CI versus NH effect on CBAS total remained significant (F(1,75) = 33.846, p < .001; partial η2 = 0.311), while socioeconomic covariates were not significant. Within the CI group, child age correlated positively with Rule-breaking Behaviors (r = 0.331, p = .037).

Conclusions

At school entry children with CI showed higher levels of socio-emotional and behavioral difficulties compared to NH peers; however, these findings should be interpreted with caution given the sample size and cross-sectional design. The results support routine psychosocial surveillance and targeted supports within CI follow-up and school settings.
目的:使用儿童行为评估量表(CBAS)比较教师报告的早期耳蜗植入儿童(CI)与正常听力儿童(NH)的社会情绪和行为功能,并检验在调整社会经济因素后群体差异是否仍然存在。方法:本横断面研究纳入80例5-6岁儿童(CI = 40; NH = 40)。教师完成CBAS量表(适应、社交焦虑、违规行为)和总分。组间比较采用Mann-Whitney U检验。经母亲教育程度、父亲教育程度和家庭收入调整后的CBAS总方差。CI组的探索性相关性检查了年龄和临床持续时间。结果:CI组与NH组相比,调整率较低(mean±SD: 61.45±15.46 vs 80.95±6.56;p 2 = 0.311),而社会经济协变量无显著性差异。在CI组内,儿童年龄与违规行为呈正相关(r = 0.331, p = 0.037)。结论:在入学时,CI患儿比NH患儿表现出更高水平的社会情绪和行为困难;然而,考虑到样本量和横截面设计,这些发现应该谨慎解释。结果支持在CI随访和学校环境中进行常规社会心理监测和有针对性的支持。
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引用次数: 0
Artificial intelligence classification of pediatric middle ear effusion using consumer-grade otoscopes 使用消费级耳镜对儿童中耳积液进行人工智能分类。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-27 DOI: 10.1016/j.ijporl.2025.112655
Sruthi Surapaneni , Nikhil Rangarajan , Kyle Davis , Katherine Pletcher , Jeffrey Flowers , Graham Strub , Abby Nolder , Deanne King , Alexander P. Marston , Mark Vecchiotti , Kristan Alfonso , Sean Evans , Anita Deshpande , Kara Prickett , April Landry , Steven Goudy , Nandini Govil , Anna Messner , Gresham Richter , Andrew R. Scott , Courtney A. Hill

Introduction

Early and accurate diagnosis of middle ear effusion in primary care settings enables timely intervention, improving long-term patient outcomes while preventing overtreatment with antibiotics. Diagnosis requires assessment of tympanic membrane mobility, but this is hampered by access to and inexperience with pneumatic otoscopy or tympanometry. This research aims to train an artificial intelligence algorithm, using tympanic membrane images captured with consumer-grade otoscopes, to accurately predict the presence or absence of pediatric middle ear effusions.

Methods

Using an over-the-counter digital otoscope, tympanic membrane images were obtained from patients aged 6 months to 6 years old undergoing tympanostomy tube placement at 4 different institutions. The images were labeled according to the middle ear findings identified by pediatric otolaryngologists during myringotomy. A deep learning neural network was trained to classify tympanic membrane images as “Effusion” or “No Effusion”.

Results

From 219 patients, 537 tympanic membrane images were obtained. Serous, mucoid or purulent effusion were represented in 263 images and 273 images demonstrated no effusion. The trained model achieved a classification accuracy of 92.1 %, a sensitivity of 90.3 %, and specificity of 93.8 %.

Discussion

This model has a balanced sensitivity and specificity comparable to or surpassing pneumatic otoscopy (94 % sensitivity, 80 % specificity) and tympanometry (90–94 % sensitivity, 50–75 % specificity). With current barriers to using the diagnostic tools recommended in clinical guidelines, it is evident that an inexpensive, objective diagnostic aid is needed for the primary care setting. This model's performance demonstrates the first step toward an accessible tool for primary care providers.
在初级保健机构中,中耳积液的早期和准确诊断可以及时干预,改善患者的长期预后,同时防止抗生素过度治疗。诊断需要评估鼓膜的流动性,但这是阻碍与气动耳镜或鼓膜测量缺乏经验。本研究旨在训练一种人工智能算法,利用消费级耳镜捕获的鼓膜图像,准确预测儿童中耳积液的存在或不存在。方法:使用非处方数字耳镜,对4个不同机构6个月至6岁接受鼓膜造瘘置管的患者进行鼓膜图像采集。这些图像是根据小儿耳鼻喉科医生在鼓膜切开术中发现的中耳结果进行标记的。训练深度学习神经网络将鼓膜图像分类为“积液”或“无积液”。结果:219例患者获得537张鼓膜图像。263张图像显示浆液、黏液或化脓性积液,273张图像显示无积液。该模型的分类准确率为92.1%,灵敏度为90.3%,特异性为93.8%。讨论:该模型具有平衡的灵敏度和特异性,可媲美或超过气动耳镜检查(94%灵敏度,80%特异性)和鼓室测量(90- 94%灵敏度,50- 75%特异性)。由于目前在使用临床指南中推荐的诊断工具方面存在障碍,很明显,初级保健机构需要一种廉价、客观的诊断工具。该模型的性能表明了向初级保健提供者提供可访问工具迈出的第一步。
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引用次数: 0
Virtual reality to create positive and timely awareness of hearing loss in middle- and secondary school 虚拟现实在中小学生中树立积极及时的听力损失意识。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-27 DOI: 10.1016/j.ijporl.2025.112660
Signe Wischmann , Lærke Hammer , Lone Jantzen , Tanja Pihl Sandager , Nete Rudbeck Kamper , Signe Toftgaard Henriksen , Ali Adjorlu , Stefania Serafin , Per Cayé-Thomasen , Lone Percy-Smith
Patient education empowers patients to control their own health and care. Taking responsibility of own hearing is important for children with hearing loss to navigate effectively in noisy environments at school. However, children must never stand alone with this responsibility. Raising positive awareness about hearing might enhance teachers' and classmates’ understanding of hearing loss, making them more competent in supporting children with hearing loss to achieve the best possible listening conditions.
In this study we explored how to create positive and timely awareness of hearing loss in middle- and secondary school. We developed a playful virtual reality game about the hearing sense and tested a setup that was suitable for group-use in classrooms. A total of 538 pupils between 10 and 16 years of age, including 26 children with hearing loss, participated in the study. Pupils, teachers and speech and language pathologists from the schools evaluated the game positively, and test before and after intervention showed a significant effect of learning. However, our study also highlighted that some children experience symptoms of cybersickness that shall not be ignored. Furthermore, implementing virtual reality in mainstream schools may present challenges in terms of economic costs and limited teacher resources.
Educational gaming certainly has the potential to support learning in schools, but future studies must investigate if virtual reality or other digital platforms are the best solution.
患者教育使患者能够控制自己的健康和护理。对自己的听力负责对于听力损失的儿童在嘈杂的学校环境中有效地导航很重要。然而,儿童绝不能独自承担这一责任。提高对听力的积极认识可以增强教师和同学对听力损失的理解,使他们更有能力支持听力损失儿童达到最佳听力状态。在本研究中,我们探讨了如何在中学生中建立积极和及时的听力损失意识。我们开发了一个关于听觉的有趣的虚拟现实游戏,并测试了一个适合在教室里集体使用的设置。共有538名10至16岁的学生参加了这项研究,其中包括26名听力受损的儿童。来自学校的学生、教师和语言病理学家对游戏的评价是积极的,干预前后的测试显示出显著的学习效果。然而,我们的研究也强调了一些孩子的晕屏症状是不容忽视的。此外,在主流学校实施虚拟现实可能会面临经济成本和教师资源有限的挑战。教育游戏确实有潜力支持学校的学习,但未来的研究必须调查虚拟现实或其他数字平台是否是最佳解决方案。
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引用次数: 0
The Grisel Syndrome: early interdisciplinary treatment needed to prevent severe upper cervical deformity - Experience from a high-volume spine center and systematic review of existing literature Grisel综合征:需要早期跨学科治疗来预防严重的上颈椎畸形——来自大容量脊柱中心的经验和对现有文献的系统回顾
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-25 DOI: 10.1016/j.ijporl.2025.112656
Vincent J. Heck , Peer Eysel , Tobias Prasse , Max J. Scheyerer , Katrin Eysel-Gosepath

Purpose

Grisel Syndrome (GS) describes a rare, non-traumatic atlantoaxial rotatory subluxation in children typically associated with upper respiratory tract infection, or otorhinolaryngological surgery. The aim of this study was to systematically review the literature regarding interdisciplinary treatment approaches, consequences of delayed or misdiagnosed GS, and upper cervical deformities resulting from misdiagnosed GS. Additionally, we share our institutional experience with this pathology.

Methods

We queried our institutional database for patients suffering from GS which were treated in our department between 2001 and 2024. A systematic literature search was conducted using Medline and the Cochrane Library, following PRISMA guidelines.

Results

Our database revealed three patients with GS. One patient with misdiagnosed of GS presented with rigid occipital rotation, ultimately progressing to occipito-atlantoaxial rotatory dislocation (OAARD). Two patients were early diagnosed and successfully treated with halo vest immobilization. The systematic literature review identified 13 cases of OAARD across 12 reports. Etiologies included upper respiratory infections, otorhinolaryngological surgery, juvenile idiopathic arthritis, and minor trauma. The average time to diagnosis of OAARD was 5.9 months (0.5–18 months). The treatment involved occipito-atlantal fusion (43 %), atlantoaxial fusion with halo vest (29 %), or traction followed by halo vest (21 %).

Conclusion

GS and OAARD are underrecognized and often diagnosed late, causing irreversible deformity and permanent loss of upper cervical spine mobility. Painful torticollis following upper respiratory tract infection, otorhinolaryngological surgery, or minor trauma should be treated as GS until proven otherwise. Early recognition and interdisciplinary treatment are crucial to prevent progression and avoid invasive surgical interventions.
目的grisel综合征(GS)描述了一种罕见的、非外伤性的儿童寰枢轴旋转半脱位,通常与上呼吸道感染或耳鼻喉外科手术有关。本研究的目的是系统地回顾有关跨学科治疗方法、延迟或误诊GS的后果以及误诊GS导致的上颈椎畸形的文献。此外,我们分享我们的机构经验与这种病理。方法查询2001年至2024年在我科就诊的GS患者的机构数据库。按照PRISMA指南,使用Medline和Cochrane图书馆进行了系统的文献检索。结果本数据库共发现3例GS患者。1例误诊为GS的患者表现为枕骨僵硬旋转,最终发展为枕寰枢旋转脱位(OAARD)。2例患者早期诊断,并成功地治疗了halo背心固定。系统文献综述在12份报告中确定了13例OAARD病例。病因包括上呼吸道感染、耳鼻喉外科手术、青少年特发性关节炎和轻微创伤。诊断为OAARD的平均时间为5.9个月(0.5 ~ 18个月)。治疗方法包括枕寰融合(43%)、寰枢融合加寰晕支架(29%)或牵引加寰晕支架(21%)。结论OAARD和OAARD未被充分认识,往往诊断较晚,可导致不可逆的上颈椎畸形和永久性的上颈椎活动能力丧失。上呼吸道感染、耳鼻喉外科手术或轻微创伤后的疼痛性斜颈应作为GS治疗,直到证明不是这样。早期识别和跨学科治疗是预防进展和避免侵入性手术干预的关键。
{"title":"The Grisel Syndrome: early interdisciplinary treatment needed to prevent severe upper cervical deformity - Experience from a high-volume spine center and systematic review of existing literature","authors":"Vincent J. Heck ,&nbsp;Peer Eysel ,&nbsp;Tobias Prasse ,&nbsp;Max J. Scheyerer ,&nbsp;Katrin Eysel-Gosepath","doi":"10.1016/j.ijporl.2025.112656","DOIUrl":"10.1016/j.ijporl.2025.112656","url":null,"abstract":"<div><h3>Purpose</h3><div>Grisel Syndrome (GS) describes a rare, non-traumatic atlantoaxial rotatory subluxation in children typically associated with upper respiratory tract infection, or otorhinolaryngological surgery. The aim of this study was to systematically review the literature regarding interdisciplinary treatment approaches, consequences of delayed or misdiagnosed GS, and upper cervical deformities resulting from misdiagnosed GS. Additionally, we share our institutional experience with this pathology.</div></div><div><h3>Methods</h3><div>We queried our institutional database for patients suffering from GS which were treated in our department between 2001 and 2024. A systematic literature search was conducted using Medline and the Cochrane Library, following PRISMA guidelines.</div></div><div><h3>Results</h3><div>Our database revealed three patients with GS. One patient with misdiagnosed of GS presented with rigid occipital rotation, ultimately progressing to occipito-atlantoaxial rotatory dislocation (OAARD). Two patients were early diagnosed and successfully treated with halo vest immobilization. The systematic literature review identified 13 cases of OAARD across 12 reports. Etiologies included upper respiratory infections, otorhinolaryngological surgery, juvenile idiopathic arthritis, and minor trauma. The average time to diagnosis of OAARD was 5.9 months (0.5–18 months). The treatment involved occipito-atlantal fusion (43 %), atlantoaxial fusion with halo vest (29 %), or traction followed by halo vest (21 %).</div></div><div><h3>Conclusion</h3><div>GS and OAARD are underrecognized and often diagnosed late, causing irreversible deformity and permanent loss of upper cervical spine mobility. Painful torticollis following upper respiratory tract infection, otorhinolaryngological surgery, or minor trauma should be treated as GS until proven otherwise. Early recognition and interdisciplinary treatment are crucial to prevent progression and avoid invasive surgical interventions.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112656"},"PeriodicalIF":1.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal impact of the coronavirus disease pandemic on pediatric adenoidectomy volume and referrals in Japan: A 6-year retrospective study 冠状病毒大流行对日本儿童腺样体切除术数量和转诊的纵向影响:一项为期6年的回顾性研究
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-24 DOI: 10.1016/j.ijporl.2025.112654
Makoto Ogawa , Takeshi Maruta , Takefumi Kamakura , Yusuke Otami , Takato Sudo , Hiroto Fujita , Nozomi Fujisawa , Shusuke Okamoto , Maki Yamashita , Suzuyo Okazaki , Kiyohito Hosokawa , Yasuo Mishiro

Objectives

To evaluate the impact of the coronavirus disease (COVID-19) pandemic and public health measures, including emergency declarations and reclassification of COVID-19, on pediatric adenoidectomy (Ad) volume and referrals diagnosed with adenoidal hypertrophy (AH) accompanied by obstructive sleep apnea (OSA) and/or otitis media with effusion (OME) in Japan.

Methods

Monthly case volumes from January 2019 to December 2024 were analyzed at a regional tertiary hospital. Trends were assessed for pediatric Ad, new referrals, general anesthesia surgeries (all departments and ENT), and regional COVID-19 cases. Ad cases were classified according to the presence of concomitant tonsillectomy (T) or tympanostomy tube insertion (TTI); referrals based on the presence of OSA or OME symptoms. The annual age trends were also evaluated.

Results

General anesthesia surgeries across the hospital and in the adult ENT department declined temporarily during the emergency declarations but rapidly recovered afterward, whereas those in the pediatric ENT department remained below the baseline even after each declaration. Notably, Ad volumes showed no apparent post-declaration recoveries and remained suppressed until 2023, except for a transient increase in summer 2021, followed by a sharp rebound after the COVID-19 reclassification. In 2024, the volumes of Ad with concurrent T and referrals for AH with OSA or OME symptoms both exceeded the pre-pandemic baseline. Surgical age declined during the pandemic, while referral age remained stable until 2023. Both ages increased in 2024.

Conclusion

The total Ad volume—especially Ad with concurrent T—and referrals for AH with OSA symptoms showed an abrupt decline immediately after the pandemic onset, followed by a sharp recovery exceeding pre-pandemic levels. These findings suggest that public health crises can disrupt elective care for chronic pediatric conditions and that the post-pandemic surge reflects behavioral changes and pent-up demand as well as possible epidemiological alterations in tonsillar tissue dynamics.
目的评价冠状病毒病(COVID-19)大流行和公共卫生措施(包括紧急宣布和COVID-19重新分类)对日本儿童腺样体切除术(Ad)数量和诊断为腺样体肥大(AH)伴阻塞性睡眠呼吸暂停(OSA)和/或积液性中耳炎(OME)的转诊的影响。方法对某地区三级医院2019年1月至2024年12月每月病例量进行分析。评估了儿科Ad、新转诊、全麻手术(所有科室和耳鼻喉科)和地区COVID-19病例的趋势。Ad病例根据合并扁桃体切除术(T)或鼓室造瘘管置入(TTI)进行分类;基于OSA或OME症状的转诊。并对年年龄趋势进行了评价。结果全院和成人耳鼻喉科的全麻手术在紧急声明期间暂时下降,但随后迅速恢复,而儿科耳鼻喉科的全麻手术即使在每次声明后仍低于基线。值得注意的是,广告量在申报后没有出现明显的复苏,直到2023年才出现抑制,除了2021年夏季短暂增长,随后在COVID-19重新分类后出现大幅反弹。2024年,合并T的Ad和伴有OSA或OME症状的AH转诊数量均超过了大流行前的基线。手术年龄在大流行期间下降,而转诊年龄在2023年之前保持稳定。这两个年龄在2024年都有所增加。结论总Ad量(尤其是同时伴有t -的Ad量)和转诊有OSA症状的AH患者在大流行发病后立即突然下降,随后急剧恢复,超过大流行前的水平。这些发现表明,公共卫生危机可能会扰乱慢性儿科疾病的选择性护理,大流行后的激增反映了行为变化和被压抑的需求,以及扁桃体组织动力学可能的流行病学改变。
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引用次数: 0
Otolaryngologic evaluation and management of nasal chondromesenchymal hamartoma 鼻软骨间充质错构瘤的耳鼻喉科评估和治疗。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-24 DOI: 10.1016/j.ijporl.2025.112657
John W. Hunsicker , Megan Ballard , Ashoke Khanwalkar , Todd M. Wine , Mark A. Lovell , Alexandra G. Suttman , Kami Wolfe Schneider , Kenny H. Chan

Introduction

Nasal chondromesenchymal hamartoma (NCMH) is a rare benign tumor of the nasal cavity and paranasal sinuses. Its clinical relevance has increased following the discovery of its association with DICER1 syndrome—a genetic condition predisposing individuals to multiple neoplasms. These two cases highlight important clinical extremes of this disease entity and offer practical evaluation and management recommendations for practicing otolaryngologists.

Methods

A retrospective review was conducted from 1999 to 2025 at a single institution. The report includes two female teenagers presented at ages 13 and 17 years, respectively, diagnosed with NCMH—one with and one without DICER1 syndrome. Key outcomes included recurrence rates, anatomical spread, genetic testing results (including evaluation for DICER1 variants), and disease-status at follow-up. A thorough literature review on NCMH and DICER1 syndrome was conducted to provide the reader with management recommendations.

Results

  • Case 1. A 13-year-old female with NCMH in the left ethmoid sinus underwent complete surgical resection and had no pathogenic DICER1 variants detected. No recurrence was observed after 3 years.
  • Case 2. A 17-year-old female with DICER1 syndrome experienced multiple recurrences of NCMH after initial diagnosis, requiring five surgical resections. She had bilateral disease and skull base involvement. She remains disease-free one year after her last surgery.

Conclusions

Genetic testing for DICER1 variants should be standard in all newly diagnosed NCMH cases. Annual nasal endoscopic and imaging follow up is recommended in all individuals with a constitutional or mosaic pathogenic DICER1 variant. There is no published guidance for recurrent NCMH at the olfactory groove/cribriform plate region. Conservative local excisions should be pursued for tumor recurrences.
鼻软骨间充质错构瘤(NCMH)是一种罕见的鼻腔和鼻窦良性肿瘤。在发现其与DICER1综合征(一种易患多种肿瘤的遗传疾病)相关后,其临床意义有所增加。这两个病例突出了这种疾病实体的重要临床极端,并为执业耳鼻喉科医生提供了实用的评估和管理建议。方法:对1999年至2025年在某一机构进行回顾性分析。该报告包括两名分别在13岁和17岁时被诊断为ncmh的女性青少年,一名患有DICER1综合征,一名没有DICER1综合征。主要结局包括复发率、解剖扩散、基因检测结果(包括DICER1变异的评估)和随访时的疾病状态。我们对NCMH和DICER1综合征进行了全面的文献综述,为读者提供治疗建议。结果:结论:DICER1变异的基因检测应作为所有新诊断的NCMH病例的标准。建议所有患有致病性DICER1变异的个体每年进行一次鼻内窥镜和影像学随访。没有关于嗅觉沟/筛板区域复发性NCMH的出版指南。肿瘤复发应行保守性局部切除。
{"title":"Otolaryngologic evaluation and management of nasal chondromesenchymal hamartoma","authors":"John W. Hunsicker ,&nbsp;Megan Ballard ,&nbsp;Ashoke Khanwalkar ,&nbsp;Todd M. Wine ,&nbsp;Mark A. Lovell ,&nbsp;Alexandra G. Suttman ,&nbsp;Kami Wolfe Schneider ,&nbsp;Kenny H. Chan","doi":"10.1016/j.ijporl.2025.112657","DOIUrl":"10.1016/j.ijporl.2025.112657","url":null,"abstract":"<div><h3>Introduction</h3><div>Nasal chondromesenchymal hamartoma (NCMH) is a rare benign tumor of the nasal cavity and paranasal sinuses. Its clinical relevance has increased following the discovery of its association with DICER1 syndrome—a genetic condition predisposing individuals to multiple neoplasms. These two cases highlight important clinical extremes of this disease entity and offer practical evaluation and management recommendations for practicing otolaryngologists.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted from 1999 to 2025 at a single institution. The report includes two female teenagers presented at ages 13 and 17 years, respectively, diagnosed with NCMH—one with and one without DICER1 syndrome. Key outcomes included recurrence rates, anatomical spread, genetic testing results (including evaluation for <em>DICER1</em> variants), and disease-status at follow-up. A thorough literature review on NCMH and DICER1 syndrome was conducted to provide the reader with management recommendations.</div></div><div><h3>Results</h3><div><ul><li><span>•</span><span><div><strong>Case 1</strong><strong>.</strong> A 13-year-old female with NCMH in the left ethmoid sinus underwent complete surgical resection and had no pathogenic <em>DICER1</em> variants detected. No recurrence was observed after 3 years.</div></span></li><li><span>•</span><span><div><strong>Case 2</strong><strong>.</strong> A 17-year-old female with DICER1 syndrome experienced multiple recurrences of NCMH after initial diagnosis, requiring five surgical resections. She had bilateral disease and skull base involvement. She remains disease-free one year after her last surgery.</div></span></li></ul></div></div><div><h3>Conclusions</h3><div>Genetic testing for <em>DICER1</em> variants should be standard in all newly diagnosed NCMH cases. Annual nasal endoscopic and imaging follow up is recommended in all individuals with a constitutional or mosaic pathogenic <em>DICER1</em> variant. There is no published guidance for recurrent NCMH at the olfactory groove/cribriform plate region. Conservative local excisions should be pursued for tumor recurrences.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112657"},"PeriodicalIF":1.3,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of prognostic factors for complicated acute rhinosinusitis in children 儿童并发急性鼻窦炎预后因素的研究
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-20 DOI: 10.1016/j.ijporl.2025.112650
Abdulaziz Alghamdi , Karine Aubry , Lucie Cussinet , Florian Bonnafous

Introduction

Acute bacterial rhinosinusitis is frequently seen in children. While complications are uncommon, they can be serious. Risk factors associated with complicated cases remain poorly defined. This study aimed primarily to identify predictors of complications in pediatric rhinosinusitis. Secondary objectives included evaluating factors associated with treatment failure and the occurrence of severe complications.

Methods

We conducted a retrospective study of all children hospitalized for acute sinusitis at Limoges University Hospital between 2010 and 2020. Data on demographics, medical history, clinical presentation, laboratory tests, and imaging were collected. Statistical analyses included multivariate logistic regression.

Results

A total of 109 patients were included. Asthma and prior use of NSAIDs were associated with higher risk of complications. Elevated CRP and lymphopenia were significant biological indicators of severity. Anaerobic Streptococci were more often associated with severe cases.

Conclusion

Asthma, NSAID use, and high CRP levels appear to be reliable indicators of complications in pediatric acute bacterial rhinosinusitis. These findings support the need for clinical vigilance and early imaging in such cases.
急性细菌性鼻窦炎常见于儿童。虽然并发症不常见,但它们可能很严重。与复杂病例相关的危险因素仍不明确。本研究的主要目的是确定儿童鼻窦炎并发症的预测因素。次要目的包括评估与治疗失败和严重并发症发生相关的因素。方法对2010年至2020年在利摩日大学医院因急性鼻窦炎住院的所有儿童进行回顾性研究。收集了人口统计学、病史、临床表现、实验室检查和影像学数据。统计分析包括多元逻辑回归。结果共纳入109例患者。哮喘和既往使用非甾体抗炎药与并发症的高风险相关。CRP升高和淋巴细胞减少是严重程度的重要生物学指标。厌氧性链球菌更常与重症病例相关。结论哮喘、使用非甾体抗炎药和高CRP水平是儿童急性细菌性鼻窦炎并发症的可靠指标。这些发现支持对此类病例进行临床警惕和早期影像学检查的必要性。
{"title":"Study of prognostic factors for complicated acute rhinosinusitis in children","authors":"Abdulaziz Alghamdi ,&nbsp;Karine Aubry ,&nbsp;Lucie Cussinet ,&nbsp;Florian Bonnafous","doi":"10.1016/j.ijporl.2025.112650","DOIUrl":"10.1016/j.ijporl.2025.112650","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute bacterial rhinosinusitis is frequently seen in children. While complications are uncommon, they can be serious. Risk factors associated with complicated cases remain poorly defined. This study aimed primarily to identify predictors of complications in pediatric rhinosinusitis. Secondary objectives included evaluating factors associated with treatment failure and the occurrence of severe complications.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of all children hospitalized for acute sinusitis at Limoges University Hospital between 2010 and 2020. Data on demographics, medical history, clinical presentation, laboratory tests, and imaging were collected. Statistical analyses included multivariate logistic regression.</div></div><div><h3>Results</h3><div>A total of 109 patients were included. Asthma and prior use of NSAIDs were associated with higher risk of complications. Elevated CRP and lymphopenia were significant biological indicators of severity. Anaerobic Streptococci were more often associated with severe cases.</div></div><div><h3>Conclusion</h3><div>Asthma, NSAID use, and high CRP levels appear to be reliable indicators of complications in pediatric acute bacterial rhinosinusitis. These findings support the need for clinical vigilance and early imaging in such cases.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"199 ","pages":"Article 112650"},"PeriodicalIF":1.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145569817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term safety and audiological results with the Bone Conduction Implant 601 in children younger than 12 years old 骨传导植入601用于12岁以下儿童的长期安全性和听力学结果
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2025-11-20 DOI: 10.1016/j.ijporl.2025.112652
Yuan Wang , Jikai Zhu , Danni Wang , Shouqin Zhao

Objective

To evaluate the long-term safety, efficacy, and satisfaction of Bonebridge implantation in children under 12 years.

Methods

This retrospective study followed 34 patients (aged 5.4–11.8 years) who underwent Bonebridge implantation between 2016 and 2020, with a median follow-up of 55 months. Audiological outcomes, including pure-tone audiometry (PTA), speech reception thresholds (SRTs), speech discrimination scores (SDSs), and sound field hearing thresholds (SFHTs) were assessed. Adverse events and patient-reported satisfaction (HDSS) were recorded.

Results

Bonebridge significantly improved speech perception (SRT: −6.20 dB in unilateral; −0.18 dB in bilateral) and SFHT (mean improvement: 20.80 dB unilateral; 29.07 dB bilateral). SDS for monosyllables, disyllables, and sentences showed substantial gains in aided conditions. Adverse events were mild to moderate, except for one serious device failure resolved with revision surgery. Sound localization accuracy decreased in patients with bilateral hearing loss who used a unilateral Bonebridge due to unilateral auditory stimulation. Patient satisfaction was high, with bilateral hearing loss reporting longer daily usage.

Conclusion

Bonebridge is a safe and effective intervention for young children under 12 years with conductive hearing loss, enhancing auditory access and quality of life.
目的评价12岁以下儿童骨桥植入术的长期安全性、有效性和满意度。方法回顾性研究2016 - 2020年间34例骨桥植入术患者(年龄5.4-11.8岁),中位随访55个月。听力学指标包括纯音测听(PTA)、语音接收阈值(srt)、语音辨别评分(SDSs)和声场听力阈值(SFHTs)。记录不良事件和患者报告满意度(HDSS)。结果骨桥显著改善了语音感知(单侧SRT:−6.20 dB;双侧- 0.18 dB)和SFHT(平均改善:单侧20.80 dB;双侧29.07 dB)。单音节、双音节和句子的SDS在辅助条件下显示出实质性的进步。不良事件为轻度至中度,除了一例严重的器械故障通过翻修手术解决。由于单侧听觉刺激,使用单侧骨桥的双侧听力损失患者声音定位准确性下降。患者满意度高,双侧听力损失患者报告每日使用时间较长。结论骨桥治疗12岁以下传导性听力损失是一种安全有效的干预方法,可改善儿童的听觉通路和生活质量。
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International journal of pediatric otorhinolaryngology
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