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Corrigendum to "Factors influencing auditory brainstem response changes in infants" [Int. J. Pediatr. Otorhinolaryngol. Volume185/issue details, cover date, 112094]. “影响婴儿听觉脑干反应变化的因素”的勘误表[j]。j . Pediatr。Otorhinolaryngol。卷185/发行详情,封面日期,112094]。
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-24 DOI: 10.1016/j.ijporl.2024.112206
Tomoko Esaki, Tadao Yoshida, Masumi Kobayashi, Kyoko Morimoto, Chisa Shibata, Michihiko Sone
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引用次数: 0
Corrigendum to "A review of the importance of top-down processing assessment in auditory processing disorder" [Int. J. Pediatr. Otorhinolaryngol. 186, (November 2024), 112128]. 关于 "听觉处理障碍中自上而下处理评估重要性的综述 "的更正 [Int. J. Pediatr. Otorhinolaryngol.
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-14 DOI: 10.1016/j.ijporl.2024.112202
Bahareh Khavarghazalani, Zahra Hosseini Dastgerdi, Morteza Hamidi Nahrani, Maryam Emadi
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引用次数: 0
Holiday letter 2024. 假日信2024。
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-04 DOI: 10.1016/j.ijporl.2024.112178
Joseph E Kerschner
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引用次数: 0
Accidental tracheostomy decannulation: Risk factors and complications in pediatric patients using the NSQIP-P database 意外气管切开断管:使用NSQIP-P数据库的儿科患者的危险因素和并发症
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-01 DOI: 10.1016/j.ijporl.2024.112174
Jacob Heninger , Arkadeep Ghosh , Matthew Rowland , Inbal Hazkani , Taher Valika , Eric C. Cheon

Background

Accidental tracheostomy decannulation (ATD) is a life-threatening event in pediatric patients. The factors associated with ATD in children are largely unknown. Utilizing the National Surgical Quality Improvement Pediatric (NSQIP-P) dataset, we sought to identify the incidence of ATD and associated factors.

Methods

Patients who underwent surgery at continuously enrolled American College of Surgeons NSQIP-P hospitals from January 1, 2012, to December 31, 2021, were included. Those who underwent a tracheostomy (CPT 31600 or 31601) as a primary or concurrent procedure were analyzed. ATD was defined by the NSQIP-P REINTUB variable. Multivariable logistic regression analysis and propensity score matching were performed to identify independent associations between demographic variables, relevant comorbidities, intraoperative factors, and ATD. Multivariable regression analyses were performed to identify any association between ATD and unplanned reoperation, pneumonia, extended length of stay, and death in 30 days in both pre-matched and matched cohorts.

Results

A total of 5229 patients undergoing tracheostomy were included in the final analysis for the pre-matched cohort. ATD occurred in 93 (1.8 %) patients, with 42 % (n = 39) of these cases occurring within the first two postoperative days. In the matched cohort, female gender (P = 0.002) and structural pulmonary/airway abnormality (P = 0.016) were independently associated with ATD. Additionally, ATD was associated with unplanned reoperation (P < 0.001) and pneumonia (P = 0.024). The pre-matched cohort showed consistent results with the matched cohort.

Discussion

Accidental decannulation is a serious complication following pediatric tracheostomy. By identifying patients at higher risk for ATD and the timing of its occurrence, providers can employ measures targeting these patients during their highest risk period. The sequelae associated with ATD further emphasize the importance of preventing this complication.
背景意外气管切开术脱管(ATD)是危及儿科患者生命的事件。与儿童ATD相关的因素在很大程度上是未知的。利用国家儿科外科质量改进(NSQIP-P)数据集,我们试图确定ATD的发生率及其相关因素。方法纳入2012年1月1日至2021年12月31日在美国外科医师学会NSQIP-P连续入选医院行手术的患者。这些接受气管切开术(CPT 31600或31601)作为主要或并发手术的患者进行了分析。ATD由NSQIP-P REINTUB变量定义。进行多变量logistic回归分析和倾向评分匹配,以确定人口统计学变量、相关合并症、术中因素和ATD之间的独立关联。进行多变量回归分析,以确定在预匹配和匹配队列中ATD与非计划再手术、肺炎、延长住院时间和30天死亡之间的关联。结果共5229例气管切开术患者被纳入预匹配队列的最终分析。93例(1.8%)患者发生ATD,其中42% (n = 39)发生在术后头两天。在匹配的队列中,女性(P = 0.002)和结构性肺/气道异常(P = 0.016)与ATD独立相关。此外,ATD与计划外再手术有关(P <;0.001)和肺炎(P = 0.024)。预匹配队列显示与匹配队列一致的结果。意外脱管是小儿气管切开术后的严重并发症。通过识别ATD高风险患者及其发生时间,提供者可以在患者风险最高的时期针对这些患者采取措施。与ATD相关的后遗症进一步强调了预防这种并发症的重要性。
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引用次数: 0
Age-dependent trends in pediatric maxillary frenum classification 儿童上颌系带分型的年龄依赖性趋势
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-01 DOI: 10.1016/j.ijporl.2024.112173
Alexandra F. Corbin , Lauren A. DiNardo , Deepthi S. Akella , Alison C. Ma , Douglas P. Nanu , Francesca C. Viola , Michele M. Carr

Objective

To describe maxillary frenum Kotlow scores in a pediatric population.

Methods

A retrospective chart review was performed for children ages 0–19 years old seen at a pediatric otolaryngology clinic by one surgeon from March–December 2022. Inclusion criteria required a recorded maxillary frenum Kotlow score. Data collected included age, gender, race/ethnicity, Kotlow score, and history of maxillary frenotomy.

Results

570 children were included, comprising 267 (46.8%) females, 302 (53.0%) males, and 1 (0.2%) transgender male. Mean age was 5.0 years (95% CI 4.6–5.4). 24 patients (4.2%) had a history of maxillary frenotomy, while 546 (95.8%) did not. Among those with no maxillary frenotomy history, 21 (3.8%) had a Kotlow 1, 127 (23.3%) Kotlow 2, 261 (47.8%) Kotlow 3, and 137 (25.1%) Kotlow 4. Kotlow scores decreased with age. For children with prior maxillary frenotomy, class 1 frenum mean age was 6.9 years, and class 4 was 0.6 years (P=.008). For those without a maxillary frenotomy history, class 1 frenum mean age was 8.7 years, and class 4 was 1.3 years (P<.001). No association was found between maxillary frenotomy history and lower Kotlow scores.

Conclusion

Nearly half of children have a Kotlow 3 maxillary frenum. Kotlow scores decrease as children age, reflecting elevated frenum insertion as the alveolar ridge develops. Otolaryngologists may find this data valuable when considering maxillary frenotomy in children.
目的探讨儿童上颌系带koflow评分。方法回顾性分析2022年3月- 12月1名外科医生在某儿科耳鼻喉科门诊就诊的0-19岁儿童的病历。纳入标准要求记录上颌系带koflow评分。收集的数据包括年龄、性别、种族/民族、koflow评分和上颌截骨史。结果共纳入570例儿童,其中女性267例(46.8%),男性302例(53.0%),变性男性1例(0.2%)。平均年龄为5.0岁(95% CI 4.6-5.4)。有上颌截骨史24例(4.2%),无上颌截骨史546例(95.8%)。在无上颌截骨史的患者中,Kotlow 1型21例(3.8%),Kotlow 2型127例(23.3%),Kotlow 3型261例(47.8%),Kotlow 4型137例(25.1%)。koflow分数随着年龄的增长而下降。既往行上颌截骨术的患儿,1级系带平均年龄为6.9岁,4级系带平均年龄为0.6岁(P= 0.008)。对于没有上颌截骨史的患者,1级系带平均年龄为8.7岁,4级系带平均年龄为1.3岁(p < 0.001)。上颌截骨史与较低的koflow评分无关联。结论近半数患儿有koflow - 3型上颌系带。Kotlow评分随着儿童年龄的增长而下降,反映了随着牙槽嵴的发育,系带插入升高。耳鼻喉科医生在考虑儿童上颌截骨手术时可能会发现这些数据很有价值。
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引用次数: 0
An innovative CRISPR/Cas9 mouse model of human isolated microtia indicates the potential contribution of CNVs near HMX1 gene 一种创新的人类分离小体的CRISPR/Cas9小鼠模型表明了靠近HMX1基因的CNVs的潜在贡献
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-12-01 DOI: 10.1016/j.ijporl.2024.112141
Wenshan Xing , Jiao Zhang , Tun Liu , Yue Wang , Jin Qian , Bingqing Wang , Yongbiao Zhang ([email protected]) , Qingguo Zhang
<div><h3>Background</h3><div>Microtia is a prevalent congenital malformation, the precise etiology and pathogenesis of which remain elusive. Mutations in the non-coding region of the <em>HMX1</em> gene have been implicated in isolated cases of microtia, emerging as a significant focus of contemporary research. Several pathogenic copy number variations (CNVs) proximal to the <em>HMX1</em> gene have been documented in wild animal populations, whereas only a single large segmental duplication in this region has been identified in humans. However, the absence of a gene-edited animal model has impeded the investigation of the unclear gene function associated with <em>HMX1</em> mutations in human isolated microtia. In this study, we sought to precisely identify the pathogenic mutation by analyzing three pedigrees alongside population controls. Subsequently, our objective was to develop a CRISPR/Cas9 gene-edited mouse model to elucidate the functional implications of the identified mutation.</div></div><div><h3>Methods</h3><div>Genomic DNA was collected from 32 affected individuals across three pedigrees, as well as from 2000 control subjects. Comprehensive genomic analyses, including genome-wide linkage analysis, targeted capture, second-generation sequencing, and copy number analysis, were conducted to identify potential mutations associated with congenital auricle malformation. CRISPR/Cas9 gene-edited murine models were generated in response to the identified mutation. The auricular phenotypes of these gene-edited mice were systematically monitored. Small-animal Micro-CT scanning was employed to identify potential craniofacial or skeletal abnormalities. Furthermore, the expression of the <em>HMX1</em> gene in the PA2 region of mouse embryos was quantified using RT-qPCR.</div></div><div><h3>Results</h3><div>A co-segregated 600 base pair duplication located on chromosome 4 (chr4:8701900-8702500, hg19) was identified in affected individuals across three pedigrees, but was absent in healthy controls. Two types of CRISPR/Cas9 gene-edited mice were subsequently generated. The knock-in (KI) mouse model was engineered by inserting one copy of the duplicated sequence directly adjacent to the mutated site, whereas the knockout (KO) mouse model was created by excising the mutation sequence. The phenotypes of different group of CRISPR/Cas9 gene-edited mice demonstrated distinct auricular deformities. Furthermore, an increase in the copy number of the mutated sequence was associated with elevated expression levels of <em>HMX1</em> in the gene-edited mouse model.</div></div><div><h3>Conclusions</h3><div>In this study, we further narrowed down and identified a 600 base pair copy number variation (CNV) located at chr4:8701900-8702500 (hg19), which is implicated in human bilateral, isolated microtia. Utilizing CRISPR/Cas9 technology, we developed novel mouse models harboring the identified mutation. These models serve as a robust platform for the comprehensive invest
背景:小体畸形是一种常见的先天性畸形,其确切的病因和发病机制尚不清楚。在HMX1基因的非编码区突变已涉及孤立病例的小个子,成为当代研究的一个重要焦点。在野生动物种群中已经发现了几种接近HMX1基因的致病性拷贝数变异(CNVs),而在人类中只发现了该区域的单个大片段重复。然而,缺乏基因编辑的动物模型阻碍了对人类分离的小体中与HMX1突变相关的不明确基因功能的研究。在这项研究中,我们试图通过分析三个家系以及人口控制来精确识别致病突变。随后,我们的目标是开发CRISPR/Cas9基因编辑的小鼠模型,以阐明鉴定突变的功能含义。方法收集3个家系32例患者的基因组DNA,以及2000例对照。全面的基因组分析,包括全基因组连锁分析、靶向捕获、第二代测序和拷贝数分析,以确定与先天性耳廓畸形相关的潜在突变。根据鉴定的突变,生成了CRISPR/Cas9基因编辑的小鼠模型。系统地监测了这些基因编辑小鼠的耳廓表型。小动物Micro-CT扫描用于识别潜在的颅面或骨骼异常。此外,采用RT-qPCR方法定量小鼠胚胎PA2区HMX1基因的表达。结果在3个家系中发现了位于4号染色体(chr4:8701900-8702500, hg19)上共分离的600个碱基对重复,但在健康对照中不存在。随后产生了两种类型的CRISPR/Cas9基因编辑小鼠。敲入(KI)小鼠模型是通过将复制序列的一个拷贝直接插入到突变位点附近来设计的,而敲除(KO)小鼠模型是通过切除突变序列来创建的。不同组CRISPR/Cas9基因编辑小鼠的表型表现出不同的耳廓畸形。此外,在基因编辑小鼠模型中,突变序列拷贝数的增加与HMX1表达水平的升高有关。结论本研究进一步缩小并鉴定出位于chr4:8701900-8702500 (hg19)的600个碱基对拷贝数变异(CNV),该变异与人类双侧分离的小脑有关。利用CRISPR/Cas9技术,我们开发了含有鉴定突变的新型小鼠模型。这些模型为全面研究该疾病的潜在机制提供了一个强大的平台。
{"title":"An innovative CRISPR/Cas9 mouse model of human isolated microtia indicates the potential contribution of CNVs near HMX1 gene","authors":"Wenshan Xing ,&nbsp;Jiao Zhang ,&nbsp;Tun Liu ,&nbsp;Yue Wang ,&nbsp;Jin Qian ,&nbsp;Bingqing Wang ,&nbsp;Yongbiao Zhang ([email protected]) ,&nbsp;Qingguo Zhang","doi":"10.1016/j.ijporl.2024.112141","DOIUrl":"10.1016/j.ijporl.2024.112141","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Microtia is a prevalent congenital malformation, the precise etiology and pathogenesis of which remain elusive. Mutations in the non-coding region of the &lt;em&gt;HMX1&lt;/em&gt; gene have been implicated in isolated cases of microtia, emerging as a significant focus of contemporary research. Several pathogenic copy number variations (CNVs) proximal to the &lt;em&gt;HMX1&lt;/em&gt; gene have been documented in wild animal populations, whereas only a single large segmental duplication in this region has been identified in humans. However, the absence of a gene-edited animal model has impeded the investigation of the unclear gene function associated with &lt;em&gt;HMX1&lt;/em&gt; mutations in human isolated microtia. In this study, we sought to precisely identify the pathogenic mutation by analyzing three pedigrees alongside population controls. Subsequently, our objective was to develop a CRISPR/Cas9 gene-edited mouse model to elucidate the functional implications of the identified mutation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Genomic DNA was collected from 32 affected individuals across three pedigrees, as well as from 2000 control subjects. Comprehensive genomic analyses, including genome-wide linkage analysis, targeted capture, second-generation sequencing, and copy number analysis, were conducted to identify potential mutations associated with congenital auricle malformation. CRISPR/Cas9 gene-edited murine models were generated in response to the identified mutation. The auricular phenotypes of these gene-edited mice were systematically monitored. Small-animal Micro-CT scanning was employed to identify potential craniofacial or skeletal abnormalities. Furthermore, the expression of the &lt;em&gt;HMX1&lt;/em&gt; gene in the PA2 region of mouse embryos was quantified using RT-qPCR.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A co-segregated 600 base pair duplication located on chromosome 4 (chr4:8701900-8702500, hg19) was identified in affected individuals across three pedigrees, but was absent in healthy controls. Two types of CRISPR/Cas9 gene-edited mice were subsequently generated. The knock-in (KI) mouse model was engineered by inserting one copy of the duplicated sequence directly adjacent to the mutated site, whereas the knockout (KO) mouse model was created by excising the mutation sequence. The phenotypes of different group of CRISPR/Cas9 gene-edited mice demonstrated distinct auricular deformities. Furthermore, an increase in the copy number of the mutated sequence was associated with elevated expression levels of &lt;em&gt;HMX1&lt;/em&gt; in the gene-edited mouse model.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In this study, we further narrowed down and identified a 600 base pair copy number variation (CNV) located at chr4:8701900-8702500 (hg19), which is implicated in human bilateral, isolated microtia. Utilizing CRISPR/Cas9 technology, we developed novel mouse models harboring the identified mutation. These models serve as a robust platform for the comprehensive invest","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112141"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of endoscopic sinus surgery in pediatric patients with sinogenic intracranial infection: A systematic review and meta-analysis 内窥镜鼻窦手术对颅内窦源性感染儿科患者的影响:系统回顾与荟萃分析
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-11-26 DOI: 10.1016/j.ijporl.2024.112176
Elysia Grose , Jenny B. Xiao , Evan Fang , Brigitte Routhier-Chevrier , Jennifer M. Siu , Nikolaus E. Wolter

Objective

This review aims to elucidate the role of endoscopic sinus surgery (ESS) on the outcomes of pediatric patients with sinogenic intracranial infections.

Methods

MEDLINE, Embase, and the Cochrane library were searched for articles that described the outcomes in pediatric patients who had intracranial complications of acute rhinosinusitis (ARS) and underwent ESS with or without open neurosurgical approaches (ONA) or external sinus approaches (ESA). Primary outcomes of interest include mortality, revision surgery, length of stay and neurological sequelae. Random effects meta-analysis was performed.

Results

Forty-eight articles met the final eligibility criteria, totaling 710 pediatric patients and 905 intracranial complications. The most common complications were subdural empyema (n = 261, 29 %), epidural abscess (n = 213, 24 %), and Pott's Puffy tumor (PPT) (n = 95, 10 %). When comparing patients who underwent ESS (alone or combined with ONA) to those who underwent ONA only, there was a decreased risk of revision surgery (RR = 0.66, 95 % CI = 0.38–1.12 and RR = 0.63, 95 % CI = 0.36–1.09, respectively) and decreased risk of neurological sequelae (RR = 0.65, 95 % CI = 0.15–2.74 and RR = 0.50, 95 % CI = 0.20–1.26, respectively), however these differences were not statistically significant. When patients who underwent combined intervention were compared to ESS only, the risk of revision surgery (RR = 1.04, 95 % CI = 0.62–1.72) and neurological sequelae (RR = 0.99, 95 % CI = 0.37–2.64) were similar. Risk of mortality was minimal and similar across all interventions.

Conclusion

The current study including primarily small retrospective studies found no statistically significant differences between children who received ESS alone, ESS with ONA or ONA alone, on mortality, revision surgery, length of stay and neurological sequelae. Although ESS may be beneficial for managing certain pediatric sinogenic intracranial infections, its true effectiveness is difficult to determine due to the variability in the types of intracranial complications and the inconsistent extent of ESS procedures reported in the literature.
本综述旨在阐明内窥镜鼻窦手术(ESS)对患有窦源性颅内感染的儿科患者的治疗效果所起的作用。方法在MEDLINE、Embase和Cochrane图书馆中检索了描述急性鼻窦炎(ARS)颅内并发症儿科患者的治疗效果的文章,这些患者接受了ESS手术,或未接受开放神经外科方法(ONA)或外窦方法(ESA)。主要研究结果包括死亡率、翻修手术、住院时间和神经系统后遗症。结果48篇文章符合最终资格标准,共有710名儿科患者和905例颅内并发症。最常见的并发症是硬膜下积液(n = 261,29%)、硬膜外脓肿(n = 213,24%)和Pott's Puffy肿瘤(PPT)(n = 95,10%)。将接受ESS(单独或与ONA联合)治疗的患者与仅接受ONA治疗的患者进行比较,结果显示,患者接受翻修手术的风险降低(RR=0.66,95% CI=0.38-1.12;RR=0.63,95% CI=0.36-1.09),神经系统后遗症的风险降低(RR=0.65,95% CI=0.15-2.74;RR=0.50,95% CI=0.20-1.26),但这些差异并无统计学意义。如果将接受联合干预的患者与仅接受ESS的患者进行比较,则翻修手术风险(RR = 1.04,95 % CI = 0.62-1.72)和神经系统后遗症风险(RR = 0.99,95 % CI = 0.37-2.64)相似。结论目前的研究主要包括小型回顾性研究,结果发现,在死亡率、翻修手术、住院时间和神经系统后遗症方面,单纯接受ESS、ESS联合ONA或单纯接受ONA的患儿之间没有统计学意义上的显著差异。尽管ESS可能有利于处理某些小儿窦源性颅内感染,但由于颅内并发症类型的差异以及文献中报道的ESS手术程度不一致,因此很难确定其真正的有效性。
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引用次数: 0
Assessing robotic-assisted procedures in pediatric otolaryngology: A systematic review and meta-analysis 评估小儿耳鼻喉科机器人辅助手术:系统回顾和荟萃分析
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-11-22 DOI: 10.1016/j.ijporl.2024.112175
Drew C. Gottman , Michaele Francesco Corbisiero , Arman Saeedi , Samantha Bothwell , Ellie Svoboda , Andy Ai , Soham Roy

Background

Robotic-assisted surgery is increasingly used in pediatric otolaryngology, offering potential benefits like improved cosmetic outcomes. However, challenges such as longer operative times, higher costs, and a steep learning curve remain.

Objectives

This systematic review and meta-analysis assess whether robotic-assisted surgery offers advantages in operative time, complication rates, hospital stay, and cosmetic outcomes compared to traditional methods in pediatric patients.

Methods

A literature search identified 20 studies, with six focused on thyroidectomy. Data on operative time, complications, hospital stay, and cosmetic outcomes were extracted and analyzed.

Results

No significant differences in operative time or complications were found for robotic-assisted thyroidectomy, but it showed superior cosmetic outcomes and, in some cases, shorter hospital stays. Additional analyses suggested feasibility and functional benefits of other robotic procedures.

Conclusions

Robotic-assisted surgery in pediatric otolaryngology is as safe and efficient as traditional methods, with added cosmetic and functional benefits. Further large-scale trials are needed.
背景机器人辅助手术越来越多地应用于小儿耳鼻喉科,具有改善美容效果等潜在优势。本系统综述和荟萃分析评估了与传统方法相比,机器人辅助手术在小儿患者的手术时间、并发症发生率、住院时间和美容效果方面是否具有优势。方法文献检索发现了 20 项研究,其中 6 项侧重于甲状腺切除术。结果未发现机器人辅助甲状腺切除术在手术时间或并发症方面有显著差异,但其美容效果更佳,某些病例的住院时间更短。结论小儿耳鼻喉科的机器人辅助手术与传统方法一样安全、高效,而且还具有美容和功能方面的优势。需要进一步开展大规模试验。
{"title":"Assessing robotic-assisted procedures in pediatric otolaryngology: A systematic review and meta-analysis","authors":"Drew C. Gottman ,&nbsp;Michaele Francesco Corbisiero ,&nbsp;Arman Saeedi ,&nbsp;Samantha Bothwell ,&nbsp;Ellie Svoboda ,&nbsp;Andy Ai ,&nbsp;Soham Roy","doi":"10.1016/j.ijporl.2024.112175","DOIUrl":"10.1016/j.ijporl.2024.112175","url":null,"abstract":"<div><h3>Background</h3><div>Robotic-assisted surgery is increasingly used in pediatric otolaryngology, offering potential benefits like improved cosmetic outcomes. However, challenges such as longer operative times, higher costs, and a steep learning curve remain.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis assess whether robotic-assisted surgery offers advantages in operative time, complication rates, hospital stay, and cosmetic outcomes compared to traditional methods in pediatric patients.</div></div><div><h3>Methods</h3><div>A literature search identified 20 studies, with six focused on thyroidectomy. Data on operative time, complications, hospital stay, and cosmetic outcomes were extracted and analyzed.</div></div><div><h3>Results</h3><div>No significant differences in operative time or complications were found for robotic-assisted thyroidectomy, but it showed superior cosmetic outcomes and, in some cases, shorter hospital stays. Additional analyses suggested feasibility and functional benefits of other robotic procedures.</div></div><div><h3>Conclusions</h3><div>Robotic-assisted surgery in pediatric otolaryngology is as safe and efficient as traditional methods, with added cosmetic and functional benefits. Further large-scale trials are needed.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"187 ","pages":"Article 112175"},"PeriodicalIF":1.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The characteristics of occult foreign body aspiration and predicting factors in children 儿童隐性异物吸入的特点和预测因素。
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-11-19 DOI: 10.1016/j.ijporl.2024.112169
Yi Zhang , Yan Li , Rui Zhang , Lin Zhong , Lina Chen

Objective

To summarize the clinical characteristics and risk factors of occult foreign body aspiration (FBA) in children, which can help with early diagnosis and timely intervention, potentially preventing further exacerbations.

Methods

We retrospectively analyzed the clinical data of the children with a final diagnosis of FBA by flexible bronchoscopy in our hospital from 2017 to 2023. The patients were divided into occult and typical groups, and two groups were compared. Multivariate binary logistic regression analysis was employed to identify risk factors associated with the occurrence of occult FBA.

Results

Among 1031 patients, the incidence of occult FBA was 4.3 % (44 cases). Compared to the typical group, children in the occult group had higher odds of ventilator management (P = .006) and longer postoperative hospitalization time (P < .001). Risk factors for predicting occult FBA were identified as age greater than 3 years old [OR: 6. 918; 95%CI (3.150–15.191)], fever [OR: 2.323; 95%CI (1.092–4.939)], inspiratory laryngeal stridor [OR: 6.514; 95%CI (1.863–22.781)], atelectasis [OR: 3.372; 95%CI (1.418–8.020)], and infiltration [OR: 2.749; 95%CI (1.195–6.323)].

Conclusions

Unlike typical FBA, the diagnosis of occult FBA is far more challenging, and occult foreign bodies are linked to a further exacerbation. This study identifies a few risk factors that have the potential to facilitate an early diagnosis of occult FBA in children. Further multicenter studies should be conducted to validate the findings.
摘要总结儿童隐匿性异物吸入(FBA)的临床特点和危险因素,有助于早期诊断和及时干预,可能避免病情进一步加重:我们回顾性分析了2017年至2023年我院经软式支气管镜检查最终确诊为FBA的患儿的临床资料。将患者分为隐匿组和典型组,两组进行比较。采用多变量二元逻辑回归分析来确定与隐匿性FBA发生相关的风险因素:结果:1031 名患者中,隐性 FBA 的发生率为 4.3%(44 例)。与典型组相比,隐匿组患儿使用呼吸机的几率更高(P = .006),术后住院时间更长(P 结论:隐匿组患儿术后住院时间更长(P = .006):与典型的 FBA 不同,隐匿性 FBA 的诊断更具挑战性,而且隐匿性异物与病情进一步恶化有关。本研究发现了一些风险因素,这些因素有可能促进儿童隐匿性 FBA 的早期诊断。应进一步开展多中心研究以验证研究结果。
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引用次数: 0
Comparison of current staging systems for predicting pediatric cholesteatoma outcomes 比较目前用于预测小儿胆脂瘤预后的分期系统。
IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2024-11-19 DOI: 10.1016/j.ijporl.2024.112170
Soorya Todatry , Robert Newsom , James Wald , Manuela Fina

Introduction

This study aims to assess the utility of the European Academy of Otology & Neurotology – Japanese Otologic Society (EAONO-JOS) and Potsic staging systems in predicting recidivism in pediatric patients with congenital (CC), primary acquired (PA), and secondary acquired (SA) cholesteatoma.

Methods

This is a retrospective study on 31 ears from 30 pediatric patients (≤18 years old) treated from 2015 to 2023 for CC, PA, and SA cholesteatoma. Surgical ears were classified according to EAONO-JOS and Potsic staging system. Surgery included transcanal endoscopic ear surgery (TEES), canal-wall up (CWU) or canal-wall down (CWD) mastoidectomy. Primary outcomes included the rate of residual disease at second-look surgery and the rate of recurrence at clinical observation. In addition, stapes erosion, incus erosion, labyrinthine fistula, and extension of disease in the mastoid at primary surgery were investigated for predictivity for recidivism. Descriptive statistics, Kaplan-Meier estimators (KM), and Fisher's Exact tests were used for statistical analysis.

Results

Based on EAONO-JOS staging, the majority (87 %) of cholesteatoma were stage II (100 % for CC, 86.7 % for PA, and 60 % for SA). The rate of residual disease was 45 % for CC, 60 % for PA, and 40 % for SA cholesteatoma. The rate of recurrent disease among the entire cohort was 6.5 %. Univariate analysis on stapes or incus erosion or mastoid extension did not predict residual disease. Within the CC cohort, outcomes suggest a potential correlation between Potsic stage and the risk of residual disease. Insufficient variability in EAONO-JOS stages precluded statistical analysis of the system's ability to predict residual disease. Among the EAONO-JOS stage II cases, those presenting with all three variables (mastoid extension, incus erosion, and stapes erosion) at primary surgery had lower KM survivability (p = 0.010). The type of surgery was predictive of residual disease: CWU was associated with a lower KM survivability compared to TEES (p = .009). CWD was not predictive, given the insufficient sample size. Among all ears, 58 % were managed with TEES.

Conclusions

In this limited cohort of pediatric CC, PA, and SA cholesteatoma, the majority of cases were managed with TEES. Among EAONO-JOS stage II cases, the simultaneous presence of mastoid extension, incus erosion, and stapes erosion at primary surgery demonstrated statistically significant decreased residual-free survivability; TEES approach at primary surgery also has a statistically significant improved residual-free survivability compared to CWU approach.
简介:本研究旨在评估欧洲耳科与神经耳科学会-日本耳科学会(EAONO-JOS)和Potsic分期系统在预测先天性(CC)、原发性获得性(PA)和继发性获得性(SA)胆脂瘤儿科患者复发率方面的实用性:这是一项回顾性研究,研究对象是2015年至2023年期间接受CC、PA和SA胆脂瘤治疗的30名儿科患者(≤18岁)的31只耳朵。手术耳根据 EAONO-JOS 和 Potsic 分期系统进行分类。手术包括经耳道内窥镜耳科手术(TEES)、管壁向上(CWU)或管壁向下(CWD)乳突切除术。主要结果包括二诊手术的残留率和临床观察的复发率。此外,还调查了镫骨糜烂、切迹糜烂、迷宫瘘管和乳突内疾病在初次手术时的扩展情况,以预测复发率。统计分析采用了描述性统计、卡普兰-梅耶估计器(KM)和费雪精确检验:根据EAONO-JOS分期,大多数胆脂瘤(87%)为II期(CC为100%,PA为86.7%,SA为60%)。CC、PA 和 SA 胆脂瘤的残留率分别为 45%、60% 和 40%。整个队列中疾病复发率为 6.5%。对镫骨或切迹糜烂或乳突扩展的单变量分析不能预测残留疾病。在CC队列中,结果表明Potsic分期与残留疾病风险之间存在潜在的相关性。由于EAONO-JOS分期的变异性不足,因此无法对该系统预测残留疾病的能力进行统计分析。在 EAONO-JOS II 期病例中,初次手术时出现所有三个变量(乳突扩展、切迹糜烂和镫骨糜烂)的病例的 KM 存活率较低(P = 0.010)。手术类型可预测残留疾病:与 TEES 相比,CWU 与较低的 KM 存活率相关(p = 0.009)。由于样本量不足,CWD 并不具有预测性。在所有病例中,58%的病例接受了TEES治疗:结论:在这批有限的小儿CC、PA和SA胆脂瘤患者中,大多数病例都采用了TEES治疗。在EAONO-JOS II期病例中,初次手术时同时存在乳突扩展、切迹糜烂和镫骨糜烂的病例,其无残留存活率在统计学上显著下降;与CWU方法相比,初次手术时采用TEES方法也在统计学上显著提高了无残留存活率。
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引用次数: 0
期刊
International journal of pediatric otorhinolaryngology
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