International journal of pediatric otorhinolaryngology最新文献

英文中文

The use of intralesional & systemic bevacizumab in severe recurrent respiratory papillomatosis: A case report 病变内和全身贝伐单抗在严重复发性呼吸道乳头状瘤病中的应用：一例报告。

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-18 DOI: 10.1016/j.ijporl.2025.112683

Róisín Kay , Hannah Griffiths , Mihiar Atfeh

Introduction

Recurrent respiratory papillomatosis (RRP) can represent a significant clinical challenge in the world of paediatric airway disease. The disease's severity and progression may vary and therefore necessitate a constantly evolving and evidence-based approach. The most recently pioneered arm of managing RRP is the use of VEGF monoclonal antibody, bevacizumab. This is a challenging case of aggressive paediatric RRP that has required the use of all available treatment modalities.

The patient

A 10-year-old girl, with significant medical and neurological history, was diagnosed with aggressive airway-obstructing RRP at 2 years of age. Over the years, she has undergone various RRP treatments, which have failed to control her disease progression.

The primary diagnoses interventions and outcomes

Following failure of traditional management adjuncts, and due to the increasing frequency and need for surgical debridement, an evidence-based decision was made to administer bevacizumab. This was administered locally, and resulted in temporary improvement. Therefore, systemic bevacizumab was eventually sought with excellent outcomes within the first year.

Conclusion

Aggressive RRP, particularly in the presence of other comorbidities, presented a management dilemma in this case. The aggressive nature of the disease necessitated out-of-box thinking, seeking evidence from the literature, and a consultation with national experts on the application of alternative treatment options such as intralesional and, subsequently, systemic bevacizumab. The latter has so far produced a yearlong excellent control of the condition. The article discusses suggestions for multicentre research into this treatment modality, and for the standardisation its administration protocols in adults and children.

简介：复发性呼吸道乳头状瘤病（RRP）可以代表一个显著的临床挑战在儿科气道疾病的世界。疾病的严重程度和进展可能各不相同，因此需要不断发展和以证据为基础的方法。管理RRP的最新先驱是使用VEGF单克隆抗体贝伐单抗。这是一个具有挑战性的侵略性儿科RRP病例，需要使用所有可用的治疗方式。患者：一名10岁女孩，有明显的医学和神经学病史，2岁时被诊断为侵袭性气道梗阻性RRP。多年来，她接受了各种RRP治疗，但未能控制她的疾病进展。初步诊断、干预措施和结果：在传统治疗手段失败后，由于手术清创的频率和需求的增加，基于证据的决定是使用贝伐单抗。这是在当地实施的，结果是暂时的改善。因此，最终寻求全身性贝伐单抗，并在第一年取得了良好的效果。结论：侵略性RRP，特别是在存在其他合并症的情况下，在本病例中出现了管理困境。这种疾病的侵袭性需要跳出常规思维，从文献中寻找证据，并与国家专家就替代治疗方案的应用进行磋商，例如局部内和随后的全身贝伐单抗。到目前为止，后者已经对病情进行了长达一年的良好控制。本文讨论了对这种治疗方式进行多中心研究的建议，并对成人和儿童的给药方案进行了标准化。

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引用次数: 0

Nationwide analysis of hospital-level disparities in peritonsillar abscess management 全国医院在膀胱周围脓肿处理上的差异分析

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-17 DOI: 10.1016/j.ijporl.2025.112688

Veronica K. Han , Hardeep S. Tiwana , Dean G. Kennedy , Bryan Wang , Shivani K. Patel , Frances R. Lara , Jessica R. Levi

Objective

Peritonsillar abscess (PTA) is a common deep neck infection that can cause severe complications if untreated. While management strategies are well established, limited evidence exists on how hospital type, safety-net (SNH) versus non–safety-net hospitals (non-SNHs), affects treatment, readmissions, and outcomes. This study evaluated national PTA outcomes with a focus on hospital type and patient demographics.

Methods

We performed a retrospective cohort study using the 2020 HCUP National Readmission Database to identify PTA admissions and 30-day readmissions. Demographic, clinical, and hospital-level factors were analyzed, including length of stay (LOS) and charges. Comparisons were made between SNHs and non-SNHs.

Results

Among 3915 admissions, the overall 30-day readmission rate was 4.9 % (n = 190). Patients under 25 years comprised 41.5 % of admissions and had higher readmission rates (5.2 %) compared with older patients. Readmissions did not differ by sex, insurance, or income quartile. Non-SNHs treated higher PTA volumes, while SNHs cared for more Medicaid and lower-income patients. Outcomes were similar across hospital types: mean LOS was slightly longer at SNHs (2.6 vs. 2.4 days, p = 0.04), and mean charges were higher at non-SNHs ($26,012 vs. $22,475, p < 0.01). Readmission rates were comparable (SNH 4.8 % vs. non-SNH 5.0 %, p = 0.71).

Conclusion

PTA management is consistent across hospital types, with no significant outcome differences between SNHs and non-SNHs. Younger patients had higher readmission risk, and cost disparities between hospital types highlight the need for further research on resource utilization and the role of tonsillectomy.

目的扁桃体周围脓肿（PTA）是一种常见的深颈部感染，若不及时治疗可引起严重的并发症。虽然管理策略已经建立，但关于医院类型、安全网（SNH）与非安全网医院（non-SNH）如何影响治疗、再入院和结果的证据有限。本研究以医院类型和患者人口统计数据为重点评估了全国PTA的结果。方法使用2020年HCUP国家再入院数据库进行回顾性队列研究，以确定PTA入院和30天再入院。分析了人口统计学、临床和医院层面的因素，包括住院时间（LOS）和收费。对snh和非snh进行比较。结果3915例入院患者中，总30天再入院率为4.9% （n = 190）。25岁以下的患者占入院人数的41.5%，与老年患者相比，再入院率更高（5.2%）。再入院率没有因性别、保险或收入四分位数而异。非snh治疗了更多的PTA，而snh治疗了更多的医疗补助和低收入患者。不同医院类型的结果相似：snh的平均生存期稍长（2.6天对2.4天，p = 0.04），非snh的平均收费较高（26,012美元对22,475美元，p < 0.01）。再入院率具有可比性（SNH为4.8%，非SNH为5.0%,p = 0.71）。结论不同医院类型的pta管理是一致的，snh和非snh的预后无显著差异。年轻患者的再入院风险较高，医院类型之间的成本差异突出了对资源利用和扁桃体切除术作用的进一步研究的必要性。

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引用次数: 0

Impact of preoperative infection severity on surgical outcomes in branchial cleft anomalies: A retrospectie cohort study 术前感染严重程度对鳃裂畸形手术结果的影响：一项回顾性队列研究。

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-15 DOI: 10.1016/j.ijporl.2025.112684

Jiajun Chen, Huijiao Xu, Bing Xu, Meng Xia, Li Yang, Feifan Chen, Kunpeng Li, Wenying Liu, Fang Hou

Objective

To evaluate the association between preoperative infection severity and surgical outcomes in patients undergoing excision for branchial cleft anomalies (BCAs).

Study design

A single-center, retrospective cohort study of patients with BCAs who underwent surgical excision at Sichuan Provincial People's Hospital between August 2014 and October 2023.

Methods

Patients were categorized into non-infected (n = 58), mildly infected (n = 169), and severely infected (n = 107) groups using a preoperative infection grading system. Data collected included demographics, clinical presentation, surgical duration, intraoperative blood loss, preoperative infection-control period, postoperative hospitalization, duration of postoperative antibiotic therapy, recurrence, infection, and other complications. Conduct appropriate statistical analyses on the above data.

Results

Age and sex distributions were similar among groups, while significant differences were observed in morphology, origin, and laterality. Non-infected and mildly infected cases were predominantly cystic, whereas severely infected cases had higher proportions of fistulae and sinuses. Preoperative infection-control periods differed significantly (P < 0.001), with longer durations in severely infected patients. Surgery duration, intraoperative blood loss, postoperative hospital stay, and duration of postoperative antibiotics increased with infection severity (all P < 0.01). No recurrence or postoperative infection occurred in the non-infected group. Mildly infected patients had low recurrence (2 %) and infection rates (4 %), while severely infected patients showed higher recurrence (8 %) and infection rates (18 %). Most events occurred within the first postoperative year.

Conclusion

Preoperative infection severity in BCAs significantly affects surgical complexity, postoperative recurrence, and infection. Careful infection control prior to surgery is crucial, particularly for severely infected cases, to optimize outcomes and minimize complications.

目的：评价鳃裂畸形（bca）手术患者术前感染严重程度与手术结果的关系。研究设计：对2014年8月至2023年10月在四川省人民医院行手术切除的bca患者进行单中心、回顾性队列研究。方法：采用术前感染分级系统将患者分为非感染组（n = 58）、轻度感染组（n = 169）和重度感染组（n = 107）。收集的资料包括人口统计学、临床表现、手术时间、术中出血量、术前感染控制期、术后住院、术后抗生素治疗时间、复发、感染和其他并发症。对上述数据进行适当的统计分析。结果：各组间年龄、性别分布相似，但在形态、起源、侧边等方面存在显著差异。未感染和轻度感染的病例以囊性为主，而严重感染的病例则有较高比例的瘘管和鼻窦。结论：bca术前感染严重程度显著影响手术复杂性、术后复发和感染。手术前仔细控制感染是至关重要的，特别是对于严重感染的病例，以优化结果并减少并发症。

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引用次数: 0

Evaluation of musical perception and emotional development in children with cochlear implants 植入人工耳蜗儿童音乐感知和情感发展的评价

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-15 DOI: 10.1016/j.ijporl.2025.112685

Artuğ Demi̇rel , Ilda Tanrisever Pehli̇van , Ozgur Surmelioglu , Caglar Eker , Elvan Onan , Muhammed Dagkiran , Suleyman Ozdemi̇r , Mustafa Mete Kıroglu

引用次数: 0

In Memoriam – Prof. Livije Kalogjera, MD, PhD (1957–2025) 纪念- Livije Kalogjera教授，医学博士，博士（1957-2025）

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-13 DOI: 10.1016/j.ijporl.2025.112668

引用次数: 0

Cleft lip/palate multidisciplinary team effectiveness on appropriate surgery timing and improving disparities 唇腭裂多学科团队在适当手术时机和改善差异方面的有效性

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-12 DOI: 10.1016/j.ijporl.2025.112676

Hrithik Praveen , Nomongo Dorjsuren , Nick De Oliveira , Stephane Braun , Izabela Galdyn , Michael Golinko , Matthew Pontell , James D. Phillips , Ryan H. Belcher

引用次数: 0

Multidisciplinary management of severe pediatric salivary gland disorders: 10-year single center experience 小儿严重唾液腺疾病的多学科管理：10年单中心经验

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-12 DOI: 10.1016/j.ijporl.2025.112680

Aidan Vanek , Jemma Maynard , Kolapo Dairo , Zialesi Adissem , Megan McNutt , Isaac Kistler , Alexandra Gach , Justin Sherrer , Prasanth Pattisapu , Tendy Chiang , Jonathan M. Grischkan

引用次数: 0

Social risk factors of recurrent croup 复发人群的社会危险因素。

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-12 DOI: 10.1016/j.ijporl.2025.112682

J.B. Eyring , Brandon M. Hemeyer , Wesley P. Allen , Christopher Stewart , Quinn T. Orb , Jeremy D. Meier , Reema Padia

Purpose

To evaluate associations between recurrent croup and neighborhood-level social determinants of health, including socioeconomic status, education, physical infrastructure, environmental exposure, and healthcare access.

Methods

We conducted a retrospective study of 252 recurrent and 594 isolated pediatric croup cases from seven hospitals and ten otolaryngology clinics across two health systems. Patient addresses were geocoded and linked to the Agency for Healthcare Research and Quality's Social Determinants of Health database. Multivariate logistic regression was used to assess associations between recurrent croup and neighborhood-level socioeconomic, environmental, and access-related factors.

Results

Patients with recurrent croup were younger (mean age 3.30 years vs. 4.84 years for isolated croup, p < .0001), and lived in areas of lower household income (p < .05) and educational attainment (p < .01). There were no significant differences in population density, air pollution, or distance to emergency departments between recurrent and isolated croup.

Conclusions

Social determinants of health, particularly lower household income and education, were associated with recurrent croup. Physicians should consider these factors in the management of recurrent croup and engage in shared decision-making with parents to improve outcomes. Further research is needed to investigate additional environmental and demographic factors.

目的：评估复发群体和社区水平的健康社会决定因素之间的关系，包括社会经济地位、教育、物质基础设施、环境暴露和医疗保健获取。方法：我们对来自两个卫生系统的7家医院和10家耳鼻喉科诊所的252例复发和594例孤立的儿科组病例进行了回顾性研究。病人的地址进行了地理编码，并与医疗保健研究和质量局的健康社会决定因素数据库相关联。多变量逻辑回归用于评估复发组与社区社会经济、环境和可及性相关因素之间的关联。结果：复发组患者更年轻（平均年龄为3.30岁，孤立组为4.84岁）。结论：健康的社会决定因素，特别是较低的家庭收入和教育程度与复发组相关。医生在治疗复发组时应考虑这些因素，并与家长共同决策以改善结果。需要进一步的研究来调查更多的环境和人口因素。

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引用次数: 0

Factors associated with misophonia in children 儿童恐音症的相关因素

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-12 DOI: 10.1016/j.ijporl.2025.112681

Katelin R. Keenehan , Erin M. Gawel , Amanda G. Baanante , Gaayathri Varavenkataraman , Alexis Rondinelli , Ellen Piccillo , Michele M. Carr

引用次数: 0

Provision of a preparatory information video for parents prior to an infant's diagnostic audiological assessment: a randomised controlled trial 在婴儿诊断性听力学评估之前为父母提供预备信息视频：一项随机对照试验。

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology

Pub Date : 2025-12-12 DOI: 10.1016/j.ijporl.2025.112679

Alison Jagger , Jane Sheehan , Kate L. Francis , Melinda Barker , Felicity Hood , Valerie Sung , Zeffie Poulakis

Purpose

To evaluate the impact of a preparatory information video on parent knowledge and anxiety. The video was viewed prior to infant diagnostic audiology, following referral from a universal newborn hearing screening program.

Methods

Randomised controlled trial comparing the provision of an information video in addition to usual care (intervention) versus usual care only. Parents of infants who were referred to audiology by the Victorian Infant Hearing Screening Program between February and December 2024 were assessed for eligibility. Parent knowledge and preparedness about infant audiological testing was measured using a study designed questionnaire (score range 0–9) and anxiety was assessed using a standardised measure. Mean differences were compared between the groups. Number of appointments required to reach a complete diagnosis was also measured and parent feedback regarding usefulness of the video was sought.

Results

The intervention group scored 2.1 (95 % confidence interval 1.6–2.6) points higher on total knowledge score compared to the usual care group. Analysis of knowledge questionnaire items at an individual level showed the proportion of correct responses was up to 48 % higher in the intervention group. No difference in anxiety scores or the number of appointments required to reach a complete diagnosis was observed. More than 94 % of participants would recommend the video to other parents.

Conclusion

Routine provision of preparatory video information prior to infant diagnostic audiology is recommended. In addition to usual care, video information embedded within clinical services can improve parent knowledge and preparedness, and support parent health literacy.

Trial ID ACTRN12623000886684.

目的：评价预备信息录像对家长知识和焦虑的影响。该视频是在婴儿诊断听力学之前观看的，随后转介了一个普遍的新生儿听力筛查项目。方法：随机对照试验比较在常规护理（干预）之外提供信息视频与仅提供常规护理。在2024年2月至12月期间，通过维多利亚婴儿听力筛查计划转介到听力学的婴儿的父母进行了资格评估。采用研究设计的问卷（得分范围0-9）测量父母对婴儿听力学测试的知识和准备程度，并采用标准化测量方法评估焦虑程度。比较各组间的平均差异。还测量了达到完整诊断所需的预约次数，并寻求家长对视频有用性的反馈。结果：干预组总知识得分较常规护理组高2.1分（95%可信区间1.6 ~ 2.6）。在个体水平上对知识问卷项目的分析表明，干预组的正确回答比例高出48%。没有观察到焦虑评分或达到完全诊断所需的预约次数的差异。超过94%的参与者会向其他家长推荐该视频。结论：建议在婴儿听力学诊断前常规提供预备视频信息。除了常规护理之外，临床服务中嵌入的视频信息可以改善家长的知识和准备，并支持家长的卫生素养。试用号ACTRN12623000886684。

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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International journal of pediatric otorhinolaryngology

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