首页 > 最新文献

International journal of pediatric otorhinolaryngology最新文献

英文 中文
Determination of the normative values of the subjective visual vertical and horizontal test in the pediatric population 确定儿童人群主观视觉垂直和水平测试的规范性值。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.ijporl.2026.112749
Sanem Can Sarıoğlu , Deniz Uğur Cengi̇z , Esra Buğra , Buşra Mazooğlu , Almıla Avşar

Background

Subjective Visual Vertical (SVV) and Subjective Visual Horizontal (SVH) tests are useful tests to identify central vestibular tone imbalances.

Aim

To determine the normal values of the Subjective Visual Vertical/Subjective Visual Horizontal (SVV/SVH) test in the pediatric group. The normative data were intended to be used as reference values in the vestibular evaluation of patients presenting with balance disorders and complaints of dizziness.

Materials and methods

The study included 60 individuals between the ages of 8 and 18. All participants underwent static and dynamic SVV and SVH testing using the Virtualis Virtual Reality device, based on a test-retest protocol with six different initial tilt angles (10°, −10°, 20°, −20°, 30°, −30°). Deviation angles were analyzed.

Results

Across all tilt angles, the mean deviation angle ranged from 1.93° to 2.44° for the static SVV test and from 1.73° to 2.31° for the static SVH test. For the dynamic SVV test, the mean deviation angle ranged from 10.47° to 11.42°, while in the dynamic SVH test, it ranged from 7.3° to 8.85° across all tilt angles.

Conclusion

As a result of this study, normative values for static and dynamic SVV and SVH tests using the Virtualis Virtual Reality Device were established for use in vestibular assessment in the pediatric population. The study contributes to the current literature by providing updated data, addressing the limited number of studies on static and dynamic SVV and SVH tests in pediatric populations.
背景:主观视觉垂直(SVV)和主观视觉水平(SVH)测试是识别中央前庭张力失衡的有用测试。目的:探讨儿童主观视垂直/主观视水平(SVV/SVH)指标的正常值。规范数据旨在作为前庭评估的参考值,以平衡障碍和头晕主诉的患者。材料和方法:该研究包括60名年龄在8至18岁之间的人。所有参与者使用Virtualis虚拟现实设备进行静态和动态SVV和SVH测试,基于六种不同初始倾斜角度(10°,-10°,20°,-20°,30°,-30°)的测试-重测试协议。分析了偏差角度。结果:在所有倾斜角度中,静态SVV测试的平均偏差角范围为1.93°至2.44°,静态SVH测试的平均偏差角范围为1.73°至2.31°。动态SVV试验的平均偏差角范围为10.47°~ 11.42°,动态SVH试验的平均偏差角范围为7.3°~ 8.85°。结论:本研究的结果是建立了使用Virtualis虚拟现实设备进行静态和动态SVV和SVH测试的规范值,用于儿科人群的前庭评估。该研究通过提供更新的数据,解决了儿科人群中静态和动态SVV和SVH检测的有限研究,从而对当前文献做出了贡献。
{"title":"Determination of the normative values of the subjective visual vertical and horizontal test in the pediatric population","authors":"Sanem Can Sarıoğlu ,&nbsp;Deniz Uğur Cengi̇z ,&nbsp;Esra Buğra ,&nbsp;Buşra Mazooğlu ,&nbsp;Almıla Avşar","doi":"10.1016/j.ijporl.2026.112749","DOIUrl":"10.1016/j.ijporl.2026.112749","url":null,"abstract":"<div><h3>Background</h3><div>Subjective Visual Vertical (SVV) and Subjective Visual Horizontal (SVH) tests are useful tests to identify central vestibular tone imbalances.</div></div><div><h3>Aim</h3><div>To determine the normal values of the Subjective Visual Vertical/Subjective Visual Horizontal (SVV/SVH) test in the pediatric group. The normative data were intended to be used as reference values in the vestibular evaluation of patients presenting with balance disorders and complaints of dizziness.</div></div><div><h3>Materials and methods</h3><div>The study included 60 individuals between the ages of 8 and 18. All participants underwent static and dynamic SVV and SVH testing using the Virtualis Virtual Reality device, based on a test-retest protocol with six different initial tilt angles (10°, −10°, 20°, −20°, 30°, −30°). Deviation angles were analyzed.</div></div><div><h3>Results</h3><div>Across all tilt angles, the mean deviation angle ranged from 1.93° to 2.44° for the static SVV test and from 1.73° to 2.31° for the static SVH test. For the dynamic SVV test, the mean deviation angle ranged from 10.47° to 11.42°, while in the dynamic SVH test, it ranged from 7.3° to 8.85° across all tilt angles.</div></div><div><h3>Conclusion</h3><div>As a result of this study, normative values for static and dynamic SVV and SVH tests using the Virtualis Virtual Reality Device were established for use in vestibular assessment in the pediatric population. The study contributes to the current literature by providing updated data, addressing the limited number of studies on static and dynamic SVV and SVH tests in pediatric populations.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112749"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of nasopharyngeal airways in Robin sequence: Insights from a retrospective cohort study with review of the literature 鼻咽气道在罗宾序列中的作用:来自回顾性队列研究的见解,并回顾了文献
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-24 DOI: 10.1016/j.ijporl.2026.112744
Shirley van de Velde , Maartje Haasnoot , Saskia Coenraad , J. Peter W. Don Griot , Aebele B. Mink van der Molen , Emma C. Paes
{"title":"The role of nasopharyngeal airways in Robin sequence: Insights from a retrospective cohort study with review of the literature","authors":"Shirley van de Velde ,&nbsp;Maartje Haasnoot ,&nbsp;Saskia Coenraad ,&nbsp;J. Peter W. Don Griot ,&nbsp;Aebele B. Mink van der Molen ,&nbsp;Emma C. Paes","doi":"10.1016/j.ijporl.2026.112744","DOIUrl":"10.1016/j.ijporl.2026.112744","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112744"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interdisciplinary approach: The importance of dysphagia diagnostics in pediatric patients 跨学科方法:儿科患者吞咽困难诊断的重要性
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.ijporl.2026.112724
Fabian Kraus, Wafaa Shehata-Dieler, Rudolf Hagen, Stephan Hackenberg
Pediatric dysphagia represents a complex and multifactorial clinical challenge with potentially profound implications for development, nutritional status, pulmonary health, and overall quality of life. In infants and children, the early identification of swallowing difficulties is critical due to their impact on growth trajectories, neurodevelopment, and the psychosocial well-being of both the child and caregivers. This comprehensive article examines the importance of a systematic, interdisciplinary diagnostic approach in evaluating pediatric dysphagia in a university hospital. Based on a ten-year retrospective cohort study involving 223 pediatric patients aged one month to sixteen years, we investigate how the integration of clinical history, physical examination, and state-of-the-art instrumental techniques - such as flexible endoscopic evaluation of swallowing (FEES) - within a collaborative, multi-specialist framework can enhance diagnostic precision. Findings underscore the necessity of individualized, developmentally sensitive diagnostic pathways involving phoniatricions, ENT specialists, pediatricians, speech-language pathologists, radiologists and nutrition experts.
小儿吞咽困难是一种复杂的多因素临床挑战,对发育、营养状况、肺部健康和整体生活质量具有潜在的深远影响。在婴儿和儿童中,吞咽困难的早期识别是至关重要的,因为它们对儿童和照顾者的生长轨迹、神经发育和社会心理健康都有影响。这篇综合性的文章探讨了在大学医院评估儿童吞咽困难的一个系统的、跨学科的诊断方法的重要性。基于一项为期10年的回顾性队列研究,涉及223名1个月至16岁的儿童患者,我们研究了如何将临床病史、体格检查和最先进的仪器技术(如柔性内窥镜吞咽评估(FEES))整合在一个协作的多专家框架内,以提高诊断精度。研究结果强调了个体化的、对发育敏感的诊断途径的必要性,这些诊断途径包括发音专家、耳鼻喉科专家、儿科医生、语言病理学家、放射科医生和营养专家。
{"title":"Interdisciplinary approach: The importance of dysphagia diagnostics in pediatric patients","authors":"Fabian Kraus,&nbsp;Wafaa Shehata-Dieler,&nbsp;Rudolf Hagen,&nbsp;Stephan Hackenberg","doi":"10.1016/j.ijporl.2026.112724","DOIUrl":"10.1016/j.ijporl.2026.112724","url":null,"abstract":"<div><div>Pediatric dysphagia represents a complex and multifactorial clinical challenge with potentially profound implications for development, nutritional status, pulmonary health, and overall quality of life. In infants and children, the early identification of swallowing difficulties is critical due to their impact on growth trajectories, neurodevelopment, and the psychosocial well-being of both the child and caregivers. This comprehensive article examines the importance of a systematic, interdisciplinary diagnostic approach in evaluating pediatric dysphagia in a university hospital. Based on a ten-year retrospective cohort study involving 223 pediatric patients aged one month to sixteen years, we investigate how the integration of clinical history, physical examination, and state-of-the-art instrumental techniques - such as flexible endoscopic evaluation of swallowing (FEES) - within a collaborative, multi-specialist framework can enhance diagnostic precision. Findings underscore the necessity of individualized, developmentally sensitive diagnostic pathways involving phoniatricions, ENT specialists, pediatricians, speech-language pathologists, radiologists and nutrition experts.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112724"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracheal cartilaginous sleeve prevalence in syndromic craniosynostosis: A single institution study 气管软骨套筒在综合征性颅缝闭塞中的患病率:一项单机构研究。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-24 DOI: 10.1016/j.ijporl.2026.112745
Roy K. Park , Katherine Hu , Zoe H. Fullerton , Melissa C. Lee , Rohit K. Khosla , Karthik Balakrishnan

Purpose

This study aimed to evaluate the incidence of tracheal cartilaginous sleeve (TCS) among syndromic craniosynostosis patients, as well as describe their genetic profiles, associated co-morbidities, and operative outcomes.

Methods

We performed a retrospective analysis of syndromic craniosynostosis patients (Apert, Crouzon, and Pfeiffer) at a single tertiary academic center between January 1, 2002, and February 1, 2024.

Results

39 patients with syndromic craniosynostosis were identified, with 17 patients (17/39, 43.6%) undergoing airway evaluation. 1 patient (1/17, 5.9%) was diagnosed with TCS, but 5 patients (5/17, 29.4%) had other airway abnormalities, all reflecting abnormalities of the airway wall or some type of airway stenosis. 28 patients (28/39, 73.7%) presented with a diagnosis of OSA, and 7 patients (7/39, 17.9%) of patients presented with choanal anomaly (atresia or stenosis). 32 patients (32/39, 82.1%) had genetic sequencing information available, with the most common mutations affecting p.P253R within the FGFR2 gene in 7 patients. No patients in our cohort presented with a p.W290 mutation and 7 patients presented with a p.C342 mutation, of which 4 patients had the p.C342Y mutation.

Conclusion

The true prevalence of TCS may be likely lower than prior reports, which may aid with alleviating some familial anxiety and provide additional context and data for medical counseling and decision-making. Nonetheless, all patients should be strongly recommended to undergo airway evaluation given the risks associated with TCS, the high prevalence of structural airway anomalies, and the overall low risk of airway evaluation.
目的:本研究旨在评估气管软骨套(TCS)在综合征性颅缝闭塞患者中的发病率,并描述其遗传谱、相关合并症和手术结果。方法:回顾性分析2002年1月1日至2024年2月1日在一个三级学术中心的综合征性颅缝闭锁患者(Apert, Crouzon和Pfeiffer)。结果:39例综合征性颅缝闭锁患者中,17例(17/39,43.6%)接受气道评估。1例(1/17,5.9%)患者被诊断为TCS, 5例(5/17,29.4%)患者有其他气道异常,均反映气道壁异常或某种类型的气道狭窄。28例(28/39,73.7%)患者诊断为OSA, 7例(7/39,17.9%)患者表现为后鼻孔异常(闭锁或狭窄)。32例患者(32/39,82.1%)有基因测序信息,其中最常见的突变影响7例FGFR2基因内的p.P253R。我们的队列中没有患者出现p.W290突变,7例患者出现p.C342突变,其中4例患者出现p.C342Y突变。结论:TCS的真实患病率可能低于之前的报道,这可能有助于减轻一些家庭焦虑,并为医疗咨询和决策提供额外的背景和数据。尽管如此,考虑到TCS的相关风险、结构性气道异常的高患病率以及气道评估的总体低风险,强烈建议所有患者接受气道评估。
{"title":"Tracheal cartilaginous sleeve prevalence in syndromic craniosynostosis: A single institution study","authors":"Roy K. Park ,&nbsp;Katherine Hu ,&nbsp;Zoe H. Fullerton ,&nbsp;Melissa C. Lee ,&nbsp;Rohit K. Khosla ,&nbsp;Karthik Balakrishnan","doi":"10.1016/j.ijporl.2026.112745","DOIUrl":"10.1016/j.ijporl.2026.112745","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to evaluate the incidence of tracheal cartilaginous sleeve (TCS) among syndromic craniosynostosis patients, as well as describe their genetic profiles, associated co-morbidities, and operative outcomes.</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of syndromic craniosynostosis patients (Apert, Crouzon, and Pfeiffer) at a single tertiary academic center between January 1, 2002, and February 1, 2024.</div></div><div><h3>Results</h3><div>39 patients with syndromic craniosynostosis were identified, with 17 patients (17/39, 43.6%) undergoing airway evaluation. 1 patient (1/17, 5.9%) was diagnosed with TCS, but 5 patients (5/17, 29.4%) had other airway abnormalities, all reflecting abnormalities of the airway wall or some type of airway stenosis. 28 patients (28/39, 73.7%) presented with a diagnosis of OSA, and 7 patients (7/39, 17.9%) of patients presented with choanal anomaly (atresia or stenosis). 32 patients (32/39, 82.1%) had genetic sequencing information available, with the most common mutations affecting p.P253R within the FGFR2 gene in 7 patients. No patients in our cohort presented with a p.W290 mutation and 7 patients presented with a p.C342 mutation, of which 4 patients had the p.C342Y mutation.</div></div><div><h3>Conclusion</h3><div>The true prevalence of TCS may be likely lower than prior reports, which may aid with alleviating some familial anxiety and provide additional context and data for medical counseling and decision-making. Nonetheless, all patients should be strongly recommended to undergo airway evaluation given the risks associated with TCS, the high prevalence of structural airway anomalies, and the overall low risk of airway evaluation.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112745"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical trial assessing the use of optical coherence tomography in decision making for children presenting with acute otitis media 临床试验评估光学相干断层扫描在儿童急性中耳炎决策中的应用
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1016/j.ijporl.2026.112728
Joseph E. Kerschner , Roger A. Daley Jr. , Roxanne Link , Rachel M. Jones , Katherine J. Peterson , Robert H. Chun , Valerie A. Flanary , Michael Gorelik , Kristina L. Keppel , Matthew Maksimoski , Marsha Malloy , Timothy J. Martin , Michael E. McCormick , Thomas C. Robey , Sadia Ansari , Grace M. Matoska , Caroline A. Rupcich , Marineta L. Saunderson , Sophie G. Shay , Cecille Sulman , Stephen A. Boppart

Objective

To identify the ability of optical coherence tomography (OCT) to assist in the diagnosis and treatment of patients presenting to a primary care provider with signs and symptoms suggesting acute otitis media (AOM).

Design-Setting-Participants

An NIH-funded clinical trial was conducted and enrolled 75 children between 1 and under 7 years of age. Children presented with complaints of ear pain or suspected ear infection from their caregiver history to primary care clinics associated with an academic children's hospital. These patients upon presentation were eligible to enroll in the trial. Following a complete history and physical exam, including pneumatic otoscopy (PO), patients were provided with a diagnosis and treatment plan. Diagnoses included: AOM, middle ear effusion without AOM, or no evidence of otitis media with a clear middle ear space. Following this, OCT was performed, and the diagnosis and treatment plan was reassessed using this data.

Results

The diagnosis and/or treatment plan changed for 15.3 % of patients following the use of OCT compared with the initial use of PO. The greatest influence was seen in the patient group with MEE without AOM, with 36 % (5/14) of these patients having their diagnosis and/or treatment plan changed after OCT was employed.

Conclusions

OCT provides an additional adjunct for primary care providers to enhance visualization of the tympanic membrane and middle ear space. This data, in our clinical trial, resulted in enhanced clinical decision making, in particular for patients with MEE who were not diagnosed with AOM on PO.

Trial registration information

Coherent Optical Detection of Middle Ear Disease (OCTII). Clinicaltrials.gov ID number: NCT05353569.
目的确定光学相干断层扫描(OCT)在初级保健提供者诊断和治疗体征和症状提示急性中耳炎(AOM)患者的能力。设计-设置-参与者一项美国国立卫生研究院资助的临床试验进行了,并招募了75名1至7岁以下的儿童。儿童提出的投诉,耳部疼痛或疑似耳部感染从他们的照顾者的历史,以初级保健诊所与学术儿童医院。这些患者在就诊时就有资格参加试验。经过完整的病史和体检,包括气动耳镜检查(PO),为患者提供诊断和治疗计划。诊断包括:中耳炎、无中耳炎的中耳积液或无中耳炎伴中耳间隙清晰的证据。在此之后,进行OCT检查,并根据这些数据重新评估诊断和治疗方案。结果使用OCT后与首次使用PO相比,15.3%的患者的诊断和/或治疗方案发生了变化。在没有AOM的MEE患者组中影响最大,36%(5/14)的患者在使用OCT后诊断和/或治疗计划发生了变化。结论超声ct为初级保健医生提供了一种增强鼓膜和中耳间隙可视化的辅助手段。在我们的临床试验中,这一数据增强了临床决策,特别是对于那些在PO上未被诊断为AOM的MEE患者。中耳疾病相干光学检测(OCTII)试验注册信息。临床试验。gov ID号:NCT05353569。
{"title":"Clinical trial assessing the use of optical coherence tomography in decision making for children presenting with acute otitis media","authors":"Joseph E. Kerschner ,&nbsp;Roger A. Daley Jr. ,&nbsp;Roxanne Link ,&nbsp;Rachel M. Jones ,&nbsp;Katherine J. Peterson ,&nbsp;Robert H. Chun ,&nbsp;Valerie A. Flanary ,&nbsp;Michael Gorelik ,&nbsp;Kristina L. Keppel ,&nbsp;Matthew Maksimoski ,&nbsp;Marsha Malloy ,&nbsp;Timothy J. Martin ,&nbsp;Michael E. McCormick ,&nbsp;Thomas C. Robey ,&nbsp;Sadia Ansari ,&nbsp;Grace M. Matoska ,&nbsp;Caroline A. Rupcich ,&nbsp;Marineta L. Saunderson ,&nbsp;Sophie G. Shay ,&nbsp;Cecille Sulman ,&nbsp;Stephen A. Boppart","doi":"10.1016/j.ijporl.2026.112728","DOIUrl":"10.1016/j.ijporl.2026.112728","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the ability of optical coherence tomography (OCT) to assist in the diagnosis and treatment of patients presenting to a primary care provider with signs and symptoms suggesting acute otitis media (AOM).</div></div><div><h3>Design-Setting-Participants</h3><div>An NIH-funded clinical trial was conducted and enrolled 75 children between 1 and under 7 years of age. Children presented with complaints of ear pain or suspected ear infection from their caregiver history to primary care clinics associated with an academic children's hospital. These patients upon presentation were eligible to enroll in the trial. Following a complete history and physical exam, including pneumatic otoscopy (PO), patients were provided with a diagnosis and treatment plan. Diagnoses included: AOM, middle ear effusion without AOM, or no evidence of otitis media with a clear middle ear space. Following this, OCT was performed, and the diagnosis and treatment plan was reassessed using this data.</div></div><div><h3>Results</h3><div>The diagnosis and/or treatment plan changed for 15.3 % of patients following the use of OCT compared with the initial use of PO. The greatest influence was seen in the patient group with MEE without AOM, with 36 % (5/14) of these patients having their diagnosis and/or treatment plan changed after OCT was employed.</div></div><div><h3>Conclusions</h3><div>OCT provides an additional adjunct for primary care providers to enhance visualization of the tympanic membrane and middle ear space. This data, in our clinical trial, resulted in enhanced clinical decision making, in particular for patients with MEE who were not diagnosed with AOM on PO.</div></div><div><h3>Trial registration information</h3><div>Coherent Optical Detection of Middle Ear Disease (OCTII). Clinicaltrials.gov ID number: NCT05353569.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112728"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular markers of pediatric cholesteatoma: A gene expression comparison with adult tissue 儿童胆脂瘤的分子标记:与成人组织的基因表达比较
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.ijporl.2026.112721
Mack J. Tempero , Peter Kfoury , Michael Seipp , Kelly Otsuka , Matthew A. Firpo , Sarah Al Nemer , Albert H. Park

Objective

This study aims to compare gene expression levels in pediatric versus adult cholesteatoma using bulk RNA sequencing.

Study design

Retrospective analysis of prospectively collected human tissue.

Setting

Tertiary medical center.

Methods

RNA sequencing was performed on 3 pediatric and 3 adult cholesteatoma tissue samples and differentially expressed genes were identified. Gene set enrichment analysis (GSEA) was performed to identify mechanistic pathways and differential cellular reprogramming.

Results

Bulk RNA sequencing of 3 pediatric and 3 adult cholesteatoma tissue samples identified 20,298 genes. Differential gene expression analysis revealed 14 genes: 6 downregulated in and 8 upregulated in pediatric cholesteatoma compared to adult tissue. The GSEA revealed 3 gene sets upregulated in pediatric samples compared to adults relevant in cholesteatoma literature: Tumor Necrosis Factor (TNF-α), Transforming Growth Factor Beta (TGF-β, and the Epithelial-Mesenchymal Transition (EMT).

Conclusion

Pediatric cholesteatoma has distinct gene expression and pathway enrichment compared to adult disease, involving inflammation and fibrosis. This study highlights the complex inflammatory process seen in pediatric cholesteatoma and suggests molecular markers that could serve as potential therapeutic targets for treatment.
目的:本研究旨在通过大规模RNA测序比较儿童和成人胆脂瘤的基因表达水平。研究设计对前瞻性收集的人体组织进行回顾性分析。三级医疗中心。方法对3例儿童和3例成人胆脂瘤组织样本进行srna测序,鉴定差异表达基因。基因集富集分析(GSEA)用于鉴定机制途径和差异细胞重编程。结果3份儿童和3份成人胆脂瘤组织样本的大量RNA测序鉴定出20,298个基因。差异基因表达分析显示14个基因:与成人组织相比,儿童胆脂瘤中6个基因下调,8个基因上调。GSEA显示,与成人文献中与胆脂瘤相关的3个基因组在儿童样本中上调:肿瘤坏死因子(TNF-α)、转化生长因子β (TGF-β)和上皮-间质转化(EMT)。结论与成人疾病相比,儿童胆脂瘤具有不同的基因表达和通路富集,涉及炎症和纤维化。这项研究强调了儿童胆脂瘤中复杂的炎症过程,并提出了可能作为潜在治疗靶点的分子标记。
{"title":"Molecular markers of pediatric cholesteatoma: A gene expression comparison with adult tissue","authors":"Mack J. Tempero ,&nbsp;Peter Kfoury ,&nbsp;Michael Seipp ,&nbsp;Kelly Otsuka ,&nbsp;Matthew A. Firpo ,&nbsp;Sarah Al Nemer ,&nbsp;Albert H. Park","doi":"10.1016/j.ijporl.2026.112721","DOIUrl":"10.1016/j.ijporl.2026.112721","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to compare gene expression levels in pediatric versus adult cholesteatoma using bulk RNA sequencing.</div></div><div><h3>Study design</h3><div>Retrospective analysis of prospectively collected human tissue.</div></div><div><h3>Setting</h3><div>Tertiary medical center.</div></div><div><h3>Methods</h3><div>RNA sequencing was performed on 3 pediatric and 3 adult cholesteatoma tissue samples and differentially expressed genes were identified. Gene set enrichment analysis (GSEA) was performed to identify mechanistic pathways and differential cellular reprogramming.</div></div><div><h3>Results</h3><div>Bulk RNA sequencing of 3 pediatric and 3 adult cholesteatoma tissue samples identified 20,298 genes. Differential gene expression analysis revealed 14 genes: 6 downregulated in and 8 upregulated in pediatric cholesteatoma compared to adult tissue. The GSEA revealed 3 gene sets upregulated in pediatric samples compared to adults relevant in cholesteatoma literature: Tumor Necrosis Factor (TNF-α), Transforming Growth Factor Beta (TGF-β, and the Epithelial-Mesenchymal Transition (EMT).</div></div><div><h3>Conclusion</h3><div>Pediatric cholesteatoma has distinct gene expression and pathway enrichment compared to adult disease, involving inflammation and fibrosis. This study highlights the complex inflammatory process seen in pediatric cholesteatoma and suggests molecular markers that could serve as potential therapeutic targets for treatment.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112721"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of central auditory processing in children with developmental dyslexia 发展性阅读障碍儿童中枢听觉加工的评价。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.ijporl.2026.112742
Senanur Kahraman Beğen , Müge Müzeyyen Çiyiltepe , Berkay Arslan

Objective

Developmental dyslexia is a neurodevelopmental disorder primarily characterized by phonological and reading difficulties. This study aimed to investigate temporal auditory processing and dichotic listening performance in children with developmental dyslexia and to explore their potential contribution to reading-related difficulties.

Methods

Sixty children aged 8–13 years participated in the study, including 30 children diagnosed with developmental dyslexia and 30 age-matched typically developing peers. Central auditory processing was assessed using the Staggered Spondaic Word (SSW) test for dichotic listening and the Frequency Pattern Test (FPT), Duration Pattern Test (DPT), and Random Gap Detection Test (RGDT) for temporal auditory processing.

Results

Children with developmental dyslexia demonstrated significantly poorer performance than controls across all temporal and dichotic auditory processing measures (p < 0.05). In the SSW test, the greatest performance difference was observed in the left competing condition. Temporal processing deficits were evident in frequency discrimination, duration pattern recognition, and gap detection tasks.

Conclusion

Children with developmental dyslexia exhibit weaknesses in temporal and dichotic auditory processing tasks. Given the linguistic demands inherent in some dichotic measures, these findings likely reflect an interaction between auditory and language-related processing rather than isolated auditory pathway dysfunction. Incorporating central auditory processing assessment into multidisciplinary dyslexia evaluations may contribute to more targeted diagnostic and intervention approaches.
目的:发展性阅读障碍是一种以语音和阅读困难为主要特征的神经发育障碍。本研究旨在探讨发展性阅读障碍儿童的时间听觉加工和二元听力表现,并探讨它们对阅读相关困难的潜在影响。方法:60名8-13岁的儿童参与研究,其中30名诊断为发展性阅读障碍的儿童和30名年龄匹配的典型发展同伴。中央听觉加工采用双听交错词(SSW)测试和时间听觉加工的频率模式测试(FPT)、持续时间模式测试(DPT)和随机间隙检测测试(RGDT)进行评估。结果:发展性阅读障碍儿童在所有时间和二元听觉加工测试中的表现明显低于对照组(p结论:发展性阅读障碍儿童在时间和二元听觉加工任务中表现出弱点。考虑到某些二分法固有的语言需求,这些发现可能反映了听觉和语言相关处理之间的相互作用,而不是孤立的听觉通路功能障碍。将中枢听觉处理评估纳入多学科阅读障碍评估可能有助于更有针对性的诊断和干预方法。
{"title":"Evaluation of central auditory processing in children with developmental dyslexia","authors":"Senanur Kahraman Beğen ,&nbsp;Müge Müzeyyen Çiyiltepe ,&nbsp;Berkay Arslan","doi":"10.1016/j.ijporl.2026.112742","DOIUrl":"10.1016/j.ijporl.2026.112742","url":null,"abstract":"<div><h3>Objective</h3><div>Developmental dyslexia is a neurodevelopmental disorder primarily characterized by phonological and reading difficulties. This study aimed to investigate temporal auditory processing and dichotic listening performance in children with developmental dyslexia and to explore their potential contribution to reading-related difficulties.</div></div><div><h3>Methods</h3><div>Sixty children aged 8–13 years participated in the study, including 30 children diagnosed with developmental dyslexia and 30 age-matched typically developing peers. Central auditory processing was assessed using the Staggered Spondaic Word (SSW) test for dichotic listening and the Frequency Pattern Test (FPT), Duration Pattern Test (DPT), and Random Gap Detection Test (RGDT) for temporal auditory processing.</div></div><div><h3>Results</h3><div>Children with developmental dyslexia demonstrated significantly poorer performance than controls across all temporal and dichotic auditory processing measures (p &lt; 0.05). In the SSW test, the greatest performance difference was observed in the left competing condition. Temporal processing deficits were evident in frequency discrimination, duration pattern recognition, and gap detection tasks.</div></div><div><h3>Conclusion</h3><div>Children with developmental dyslexia exhibit weaknesses in temporal and dichotic auditory processing tasks. Given the linguistic demands inherent in some dichotic measures, these findings likely reflect an interaction between auditory and language-related processing rather than isolated auditory pathway dysfunction. Incorporating central auditory processing assessment into multidisciplinary dyslexia evaluations may contribute to more targeted diagnostic and intervention approaches.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"202 ","pages":"Article 112742"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Household button battery coating materials for injury prevention in esophageal impaction: An ex vivo porcine study 家用纽扣电池涂层材料预防食管嵌塞损伤:猪的离体研究。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 Epub Date: 2026-01-05 DOI: 10.1016/j.ijporl.2026.112713
Jacob G.J. Wihlidal , Elysia M. Grose , Yasmin Madan , Evan J. Propst , Adrian L. James , Jennifer M. Siu , Nikolaus E. Wolter
{"title":"Household button battery coating materials for injury prevention in esophageal impaction: An ex vivo porcine study","authors":"Jacob G.J. Wihlidal ,&nbsp;Elysia M. Grose ,&nbsp;Yasmin Madan ,&nbsp;Evan J. Propst ,&nbsp;Adrian L. James ,&nbsp;Jennifer M. Siu ,&nbsp;Nikolaus E. Wolter","doi":"10.1016/j.ijporl.2026.112713","DOIUrl":"10.1016/j.ijporl.2026.112713","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"201 ","pages":"Article 112713"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADHEAR in infants with Down syndrome and minimal hearing loss ADHEAR在患有唐氏综合症和轻度听力损失的婴儿中的应用。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 Epub Date: 2026-01-11 DOI: 10.1016/j.ijporl.2026.112722
Evette A. Ronner , Nicole Kim , Michael Cheung , Heidi Leonard , Julie Arenberg , Michael S. Cohen
{"title":"ADHEAR in infants with Down syndrome and minimal hearing loss","authors":"Evette A. Ronner ,&nbsp;Nicole Kim ,&nbsp;Michael Cheung ,&nbsp;Heidi Leonard ,&nbsp;Julie Arenberg ,&nbsp;Michael S. Cohen","doi":"10.1016/j.ijporl.2026.112722","DOIUrl":"10.1016/j.ijporl.2026.112722","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"201 ","pages":"Article 112722"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative complications following tonsillectomy in children with Ehlers-Danlos Syndrome Ehlers-Danlos综合征患儿扁桃体切除术后的并发症。
IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.1016/j.ijporl.2026.112719
Murilo de Santana Hager , Mary Youssef , Gaayathri Varavenkataraman , Nicole Favre , Michele M. Carr
{"title":"Postoperative complications following tonsillectomy in children with Ehlers-Danlos Syndrome","authors":"Murilo de Santana Hager ,&nbsp;Mary Youssef ,&nbsp;Gaayathri Varavenkataraman ,&nbsp;Nicole Favre ,&nbsp;Michele M. Carr","doi":"10.1016/j.ijporl.2026.112719","DOIUrl":"10.1016/j.ijporl.2026.112719","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"201 ","pages":"Article 112719"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International journal of pediatric otorhinolaryngology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1