Pub Date : 2022-12-01DOI: 10.32402/dovkil2022.04.036
Yu.I. Bandazhevskyi, N. Dubova
The purpose of the study: to assess the impact of incorporated 137Cs radionuclides on the physical development of boys and girls living near the Chornobyl Exclusion Zone, taking into account the state of the folate cycle and the MTHFR:C677T genetic polymorphism. Research methods: іnstrumental, laboratory, mathematical and statistical. Results: Within the framework of international projects, an assessment of physical development was carried out according to the Rohrer index (IR), the levels and relationship of incorporated 137Cs, vitamins B6, B9, B12, homocysteine (Hcy), allelic variants of the MTHFR:C677T genetic polymorphism were determined in 260 children aged 13-17 years old from Ivankivskyi and Polisskyi districts of the Kyiv region, bordering the Chornobyl Exclusion Zone. It has been established that among the surveyed, the more proportion is the subgroup of adolescents with harmonious physical development (respectively, for boys - 70.40%, for girls - 65.93%). It was shown that boys and girls with disharmonious high physical development (respectively 15.20% and 25.19%) contained significantly less 137Cs radionuclides in their bodies, compared with children from the subgroups of harmonious and disharmonious low physical development. In the analyzed groups of boys and girls, an inverse correlation was recorded between the specific activity of 137Cs and the values of anthropometric indicators. The most pronounced inverse relationship between the specific activity of 137Cs and the values of mass, as well as body length and IR, was found in the subgroup of harmoniously developed girls. The subgroup of harmoniously developed boys differed from the subgroup of harmoniously developed girls by a higher specific activity of 137Cs in the body and a higher level of Hcy in the blood. The decrease in the level of Hcy in the blood of harmoniously developed girls, compared with harmoniously developed boys, may be associated with a higher level of vitamin B12 in the blood, as well as with a more intense functioning of the trans-sulfurization cycle. Comparative analysis showed that in the subgroup of girls with overweight, the proportion of cases of carriage of genotypes composed of neutral alleles of the C/C polymorphism MTHFR:677 is greater than in the subgroup of harmoniously developed girls. At the same time, a lower specific activity of 137Cs in their body was registered. It is concluded that incorporated 137Cs radionuclides cause a decrease in body weight in children living in the area affected by the accident at the Chоrnobyl nuclear power plant. At the same time, there is a metabolic disorder, in the form of an increase in the content of Hcy in the blood, more pronounced in boys. The process of incorporation of 137Cs radionuclides into the body of children may be associated with the T allele of the MTHFR:C677 polymorphism, which affects the activity of methylenetetrahydrofolate reductase.
{"title":"Th137Cs radionuclides, folate cycle and physical development of children living near the Chornobyl exclusion zone","authors":"Yu.I. Bandazhevskyi, N. Dubova","doi":"10.32402/dovkil2022.04.036","DOIUrl":"https://doi.org/10.32402/dovkil2022.04.036","url":null,"abstract":"The purpose of the study: to assess the impact of incorporated 137Cs radionuclides on the physical development of boys and girls living near the Chornobyl Exclusion Zone, taking into account the state of the folate cycle and the MTHFR:C677T genetic polymorphism. Research methods: іnstrumental, laboratory, mathematical and statistical. Results: Within the framework of international projects, an assessment of physical development was carried out according to the Rohrer index (IR), the levels and relationship of incorporated 137Cs, vitamins B6, B9, B12, homocysteine (Hcy), allelic variants of the MTHFR:C677T genetic polymorphism were determined in 260 children aged 13-17 years old from Ivankivskyi and Polisskyi districts of the Kyiv region, bordering the Chornobyl Exclusion Zone. It has been established that among the surveyed, the more proportion is the subgroup of adolescents with harmonious physical development (respectively, for boys - 70.40%, for girls - 65.93%). It was shown that boys and girls with disharmonious high physical development (respectively 15.20% and 25.19%) contained significantly less 137Cs radionuclides in their bodies, compared with children from the subgroups of harmonious and disharmonious low physical development. In the analyzed groups of boys and girls, an inverse correlation was recorded between the specific activity of 137Cs and the values of anthropometric indicators. The most pronounced inverse relationship between the specific activity of 137Cs and the values of mass, as well as body length and IR, was found in the subgroup of harmoniously developed girls. The subgroup of harmoniously developed boys differed from the subgroup of harmoniously developed girls by a higher specific activity of 137Cs in the body and a higher level of Hcy in the blood. The decrease in the level of Hcy in the blood of harmoniously developed girls, compared with harmoniously developed boys, may be associated with a higher level of vitamin B12 in the blood, as well as with a more intense functioning of the trans-sulfurization cycle. Comparative analysis showed that in the subgroup of girls with overweight, the proportion of cases of carriage of genotypes composed of neutral alleles of the C/C polymorphism MTHFR:677 is greater than in the subgroup of harmoniously developed girls. At the same time, a lower specific activity of 137Cs in their body was registered. It is concluded that incorporated 137Cs radionuclides cause a decrease in body weight in children living in the area affected by the accident at the Chоrnobyl nuclear power plant. At the same time, there is a metabolic disorder, in the form of an increase in the content of Hcy in the blood, more pronounced in boys. The process of incorporation of 137Cs radionuclides into the body of children may be associated with the T allele of the MTHFR:C677 polymorphism, which affects the activity of methylenetetrahydrofolate reductase.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125142444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.32402/dovkil2022.04.058
Priputina Ls, Vorob'eva Tv, Bondar' VIu
The significant expansion of international trade in food additives (FA) made it necessary to solve the problem of the expediency of using FA in the production, packaging, storage, transportation and sale of food products (FP). In Ukraine, the use of FA is regulated by the «Sanitary Rules for the Use of Food Additives », which fully meet international requirements. To improve the international trade of FP containing FA, the Council of the EU developed and tested a rational system of digital codification of FA with the letter «E» and a three- or fourdigit number (code) assigned to a specific FA. It is included in Codex Alimentarius, EC Directives, FAO/WHO as an international digital codification system. The FA code confirms that this compound has been tested for safety, established purity criteria and hygienic standards for FP. In accordance with the Law of Ukraine «On the Safety and Quality of Food Products», the sale and use of domestic and imported food products without labeling in the national language about the composition of the food product with a list of the names of FA that were used in the process of its manufacture is prohibited. The majority of FA do not affect the body of consumers, are inert in used quantities, but some of them are capable of causing an adverse effect on the human body when ingested in significant quantities, therefore their hygienic regulation is extremely necessary.
{"title":"Hygienic aspects of the use of food additives (lecture)","authors":"Priputina Ls, Vorob'eva Tv, Bondar' VIu","doi":"10.32402/dovkil2022.04.058","DOIUrl":"https://doi.org/10.32402/dovkil2022.04.058","url":null,"abstract":"The significant expansion of international trade in food additives (FA) made it necessary to solve the problem of the expediency of using FA in the production, packaging, storage, transportation and sale of food products (FP). In Ukraine, the use of FA is regulated by the «Sanitary Rules for the Use of Food Additives », which fully meet international requirements. To improve the international trade of FP containing FA, the Council of the EU developed and tested a rational system of digital codification of FA with the letter «E» and a three- or fourdigit number (code) assigned to a specific FA. It is included in Codex Alimentarius, EC Directives, FAO/WHO as an international digital codification system. The FA code confirms that this compound has been tested for safety, established purity criteria and hygienic standards for FP. In accordance with the Law of Ukraine «On the Safety and Quality of Food Products», the sale and use of domestic and imported food products without labeling in the national language about the composition of the food product with a list of the names of FA that were used in the process of its manufacture is prohibited. The majority of FA do not affect the body of consumers, are inert in used quantities, but some of them are capable of causing an adverse effect on the human body when ingested in significant quantities, therefore their hygienic regulation is extremely necessary.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115349571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.32402/dovkil2022.04.020
A. Syrota, O. Vavrinevych, S. Omelchuk, A. Blagaia
The problem of pesticide poisoning is particularly acute among countries whose primary source of income is agriculture (India, China, Brazil, Mexico, Argentina etc.). About 3 million cases of intentional and unintentional pesticide poisoning are reported in the world annually, resulting in the death of more than 250000 people. In Ukraine, by 2020, more than 250 pesticide preparations containing active substances of the triazole class. Aim of the work. Hygienic assessment of the population risk after consumption of agricultural products grown with the application of triazole class-based fungicides. Materials and methods. We analyzed the resistance parameters of triazole fungicides (difenoconazole, prothioconazole, cyproconazole, and metconazole) and strobilurin (azoxystrobin) in various crops. To determine the content of active substances in crops, we used modern methods of high-performance liquid and gas chromatography. For the integral assessment of the hazard indicators was used, the indicators of the allowable daily intake, the half-life periods in plants and the average daily consumption of the product were evaluated. Research results. The risk assessment for the population, calculated according to the methodology showed that the risk values of triazoles were 0.0002-0.2239, strobilurins – 0.0002-0.0016, which does not exceed the acceptable (less than 1). Calculations carried out according to the method show that all studied compounds of triazoles class belong to the moderately hazardous when consuming treated products of rapeseed, soybean, sunflower, sugar beet and hazardous when consuming cereals; strobilurin - low hazard when consumed the most of the studied cultures. Differences in hazard classes are primarily due to differences in the behaviour of pesticides in different crops and the length of the vegetative season.
{"title":"Hygienic assessment of the population risk after consumption of agricultural products grown with the application of triazole class-based fungicides","authors":"A. Syrota, O. Vavrinevych, S. Omelchuk, A. Blagaia","doi":"10.32402/dovkil2022.04.020","DOIUrl":"https://doi.org/10.32402/dovkil2022.04.020","url":null,"abstract":"The problem of pesticide poisoning is particularly acute among countries whose primary source of income is agriculture (India, China, Brazil, Mexico, Argentina etc.). About 3 million cases of intentional and unintentional pesticide poisoning are reported in the world annually, resulting in the death of more than 250000 people. In Ukraine, by 2020, more than 250 pesticide preparations containing active substances of the triazole class. Aim of the work. Hygienic assessment of the population risk after consumption of agricultural products grown with the application of triazole class-based fungicides. Materials and methods. We analyzed the resistance parameters of triazole fungicides (difenoconazole, prothioconazole, cyproconazole, and metconazole) and strobilurin (azoxystrobin) in various crops. To determine the content of active substances in crops, we used modern methods of high-performance liquid and gas chromatography. For the integral assessment of the hazard indicators was used, the indicators of the allowable daily intake, the half-life periods in plants and the average daily consumption of the product were evaluated. Research results. The risk assessment for the population, calculated according to the methodology showed that the risk values of triazoles were 0.0002-0.2239, strobilurins – 0.0002-0.0016, which does not exceed the acceptable (less than 1). Calculations carried out according to the method show that all studied compounds of triazoles class belong to the moderately hazardous when consuming treated products of rapeseed, soybean, sunflower, sugar beet and hazardous when consuming cereals; strobilurin - low hazard when consumed the most of the studied cultures. Differences in hazard classes are primarily due to differences in the behaviour of pesticides in different crops and the length of the vegetative season.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115596236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.32402/dovkil2022.04.004
N. Prokopenko
The article substantiates the main problems affecting the state and development of the labor potential of Ukrainian regions and the state as a whole: demographic, psychophysiological, social, economic, educational. Theoretical and methodological aspects and the evolution of approaches to the study of essence and assessment of the labor potential of the region are highlighted. The author’s approach to the interpretation of the structure of the labor potential of the region with the justification of its quantitative and qualitative characteristics is proposed, methodological tools for assessing the state of the labor potential of the region are developed. The methodology was tested on official statistical data on the regions of Ukraine for 2019. Based on the obtained integral characteristics, the Ukrainian regions were grouped taking into account the qualitative and quantitative components of the labor potential. The results of the study can be used in the course of the implementation of the regional policy. Keywords: labor potential of the region, characteristics of labor potential, combined approach, comprehensive assessment, state regional policy.
{"title":"Labor potential of the regions of Ukraine: medical and demographic, socio-economic, educational and qualification aspects","authors":"N. Prokopenko","doi":"10.32402/dovkil2022.04.004","DOIUrl":"https://doi.org/10.32402/dovkil2022.04.004","url":null,"abstract":"The article substantiates the main problems affecting the state and development of the labor potential of Ukrainian regions and the state as a whole: demographic, psychophysiological, social, economic, educational. Theoretical and methodological aspects and the evolution of approaches to the study of essence and assessment of the labor potential of the region are highlighted. The author’s approach to the interpretation of the structure of the labor potential of the region with the justification of its quantitative and qualitative characteristics is proposed, methodological tools for assessing the state of the labor potential of the region are developed. The methodology was tested on official statistical data on the regions of Ukraine for 2019. Based on the obtained integral characteristics, the Ukrainian regions were grouped taking into account the qualitative and quantitative components of the labor potential. The results of the study can be used in the course of the implementation of the regional policy. Keywords: labor potential of the region, characteristics of labor potential, combined approach, comprehensive assessment, state regional policy.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129836174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.32402/dovkil2022.04.044
L. Tomashevska, V. Prokopov, T.Ye. Kravchun, O. Lypovetska
Objective: study of the effect of chloroform and aluminum sulfate on hematological indicators of experimental animals. Materials and methods: combined effect of chloroform and aluminum sulfate on hematological indicators. Results: Evaluating the results of research under the conditions of the combined effect of chloroform and aluminum sulfate, it can be stated that the most pronounced changes are observed in groups of animals with the maximum level of load - 3 and 5 MPC, under the conditions of the isolated effect of chloroform and aluminum sulfate, and under the conditions of their combined effect. The detected changes indicate the influence of active factors on the cooperative nature of oxygen binding by hemoglobin, which affects the provision of the transport function of the protein and, accordingly, on the protective function of the group of leukocytes.Changes in the leukogram reflect the phases of the development of protective and adaptive processes in the immune-competent blood system and may indicate the formation of adaptive and adaptive reactions aimed at maintaining the stability of the body’s homeostasis with their subsequent disruption and exhaustion of compensatory mechanisms. Conclusions.The specified changes in the morphological composition of blood can be signs of: violations of physiological processes occurring in the body, slowing down of redox reactions, hypoxic manifestations, reduction and weakening of the immune response and reactivity, which cannot but be reflected in the vital activity and life expectancy of experimental animals.The extrapolation of these results to humans allows us to assume that the population’s constant consumption of drinking water with an excessive content of chloroform and aluminum sulfate over time can lead to changes in the blood system, weakening of the body’s protective immune function and creating conditions for the development of non-infectious pathology.
{"title":"Study of isolated and combined effects of chloroform and aluminum sulfate with drinking water on hematological indicators of animals","authors":"L. Tomashevska, V. Prokopov, T.Ye. Kravchun, O. Lypovetska","doi":"10.32402/dovkil2022.04.044","DOIUrl":"https://doi.org/10.32402/dovkil2022.04.044","url":null,"abstract":"Objective: study of the effect of chloroform and aluminum sulfate on hematological indicators of experimental animals. Materials and methods: combined effect of chloroform and aluminum sulfate on hematological indicators. Results: Evaluating the results of research under the conditions of the combined effect of chloroform and aluminum sulfate, it can be stated that the most pronounced changes are observed in groups of animals with the maximum level of load - 3 and 5 MPC, under the conditions of the isolated effect of chloroform and aluminum sulfate, and under the conditions of their combined effect. The detected changes indicate the influence of active factors on the cooperative nature of oxygen binding by hemoglobin, which affects the provision of the transport function of the protein and, accordingly, on the protective function of the group of leukocytes.Changes in the leukogram reflect the phases of the development of protective and adaptive processes in the immune-competent blood system and may indicate the formation of adaptive and adaptive reactions aimed at maintaining the stability of the body’s homeostasis with their subsequent disruption and exhaustion of compensatory mechanisms. Conclusions.The specified changes in the morphological composition of blood can be signs of: violations of physiological processes occurring in the body, slowing down of redox reactions, hypoxic manifestations, reduction and weakening of the immune response and reactivity, which cannot but be reflected in the vital activity and life expectancy of experimental animals.The extrapolation of these results to humans allows us to assume that the population’s constant consumption of drinking water with an excessive content of chloroform and aluminum sulfate over time can lead to changes in the blood system, weakening of the body’s protective immune function and creating conditions for the development of non-infectious pathology.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133375466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.32402/dovkil2022.03.048
N. Operchuk
Objective: The aim of the work is to develop approaches to improving the information and analytical support for monitoring epidemiological studies and infectious diseases in the activities of public health institutions. Materials and methods: The studies were carried out on the basis of a retrospective review of long-term monitoring of epidemiological observations of infectious morbidity and indicators of microbiological and chemical pollution of environmental factors, performed by the state institution «Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine». In this case, the following methods were used: dialectical - to determine the essence of information and analytical support for the activities of public health institutions; functional, comparative analysis - to analyze the activities of the state institution "Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine"; model, integrated approaches - to develop a model of information and analytical support for the activities of public health institutions and measures for its implementation in practice; methods of statistical analysis - to determine the characteristics of the study of environmental objects and the dynamics of infectious diseases in the population. Results: According to monitoring observations of environmental objects in medical institutions, preschool and general educational institutions, social security institutions of the Kirovohrad region for 2020, which included data from 4196 studies, it was found that almost 15% of them do not meet the requirements of regulatory documents. At the same time, microbiological studies included 1207 samples and measurements, of which 117 samples (9.7%) were inappropriate, sanitary-chemical studies amounted to 2989 samples, of which 146 samples were inappropriate (4.9%) exceeding the permissible standards. The largest number of samples that do not comply with regulatory documents and pose a threat to human health were found in non-centralized water supply 77 samples. The analysis of the infectious morbidity of the population in the Kirovohrad region covered the period of 2018-2020, the dynamic review of which showed that, according to the criterion of general morbidity, the number of cases of infectious diseases is growing over time, while the incidence of infectious diseases in children tends to decrease. A number of shortcomings in accounting and data processing have been identified. Conclusions: The expediency of improving the methodological, software and technological support of the information and analytical direction of the functioning of the state institution "Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine" is shown. This will improve the efficiency and quality of the implementation of monitoring studies, as well as the processing and analysis of the obtained data on the state of the environment and p
{"title":"Analytical review of the results of monitoring epidemiological studies and infectious disease in the Kirovohrad region","authors":"N. Operchuk","doi":"10.32402/dovkil2022.03.048","DOIUrl":"https://doi.org/10.32402/dovkil2022.03.048","url":null,"abstract":"Objective: The aim of the work is to develop approaches to improving the information and analytical support for monitoring epidemiological studies and infectious diseases in the activities of public health institutions. Materials and methods: The studies were carried out on the basis of a retrospective review of long-term monitoring of epidemiological observations of infectious morbidity and indicators of microbiological and chemical pollution of environmental factors, performed by the state institution «Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine». In this case, the following methods were used: dialectical - to determine the essence of information and analytical support for the activities of public health institutions; functional, comparative analysis - to analyze the activities of the state institution \"Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine\"; model, integrated approaches - to develop a model of information and analytical support for the activities of public health institutions and measures for its implementation in practice; methods of statistical analysis - to determine the characteristics of the study of environmental objects and the dynamics of infectious diseases in the population. Results: According to monitoring observations of environmental objects in medical institutions, preschool and general educational institutions, social security institutions of the Kirovohrad region for 2020, which included data from 4196 studies, it was found that almost 15% of them do not meet the requirements of regulatory documents. At the same time, microbiological studies included 1207 samples and measurements, of which 117 samples (9.7%) were inappropriate, sanitary-chemical studies amounted to 2989 samples, of which 146 samples were inappropriate (4.9%) exceeding the permissible standards. The largest number of samples that do not comply with regulatory documents and pose a threat to human health were found in non-centralized water supply 77 samples. The analysis of the infectious morbidity of the population in the Kirovohrad region covered the period of 2018-2020, the dynamic review of which showed that, according to the criterion of general morbidity, the number of cases of infectious diseases is growing over time, while the incidence of infectious diseases in children tends to decrease. A number of shortcomings in accounting and data processing have been identified. Conclusions: The expediency of improving the methodological, software and technological support of the information and analytical direction of the functioning of the state institution \"Kirovohrad Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine\" is shown. This will improve the efficiency and quality of the implementation of monitoring studies, as well as the processing and analysis of the obtained data on the state of the environment and p","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124278500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.32402/dovkil2022.03.014
Yu.I. Bandazhevskyi, N. Dubova
The aim of study: determination of the genetic factor’s involvement (MTHFR:C677T polymorphism), which affects the activity of the main enzyme of the folate cycle, methylenetetrahydrofolate reductase, and environmental exposure, including the radiation factor, in the occurrence of hyperhomocysteinemia in children which living near the Chornobyl Exclusion Zone (ChEZ). Research methods. Immunochemical, mathematical and statistical. Results. Within the framework of international projects, the levels of homocysteine (Hcy) and allelic variants of the genetic polymorphism MTHFR:C677T were determined in 624 children aged 13-17 years old from Ivankivskyi and Poliskyi districts of the Kyiv region. It has been established that an increase in the level of Hcy in the blood and an increase in the number of cases of hyperhomocysteinemia in the examined groups of children are associated with forest fires in the ChEZ in 2015 and 2020. Under conditions of pronounced exposure to radioactive agents and combustion products of forest trees, the proportion of cases of hyperhomocysteinemia in groups of children with and without the T allele of the MTHFR:677 polymorphism in the genome did not have statistical differences. An indicator of ecological trouble in the ChEZ and adjacent areas is an increase, above the physiological level, in the concentration of Hcy in the blood of adolescent children with the absence of the T allele of the MTHFR:677 polymorphism in the genome. Conclusion. In areas affected by the accident at the Chornobyl nuclear power plant, it is necessary to constantly conduct regular monitoring studies of the health of children, using tests for the content of Hcy in the blood and the state of the folate cycle genes.
{"title":"Hyperhomocysteinemia in children is an indicator of environmental problems associated with the chоrnobyl exclusion zone","authors":"Yu.I. Bandazhevskyi, N. Dubova","doi":"10.32402/dovkil2022.03.014","DOIUrl":"https://doi.org/10.32402/dovkil2022.03.014","url":null,"abstract":"The aim of study: determination of the genetic factor’s involvement (MTHFR:C677T polymorphism), which affects the activity of the main enzyme of the folate cycle, methylenetetrahydrofolate reductase, and environmental exposure, including the radiation factor, in the occurrence of hyperhomocysteinemia in children which living near the Chornobyl Exclusion Zone (ChEZ). Research methods. Immunochemical, mathematical and statistical. Results. Within the framework of international projects, the levels of homocysteine (Hcy) and allelic variants of the genetic polymorphism MTHFR:C677T were determined in 624 children aged 13-17 years old from Ivankivskyi and Poliskyi districts of the Kyiv region. It has been established that an increase in the level of Hcy in the blood and an increase in the number of cases of hyperhomocysteinemia in the examined groups of children are associated with forest fires in the ChEZ in 2015 and 2020. Under conditions of pronounced exposure to radioactive agents and combustion products of forest trees, the proportion of cases of hyperhomocysteinemia in groups of children with and without the T allele of the MTHFR:677 polymorphism in the genome did not have statistical differences. An indicator of ecological trouble in the ChEZ and adjacent areas is an increase, above the physiological level, in the concentration of Hcy in the blood of adolescent children with the absence of the T allele of the MTHFR:677 polymorphism in the genome. Conclusion. In areas affected by the accident at the Chornobyl nuclear power plant, it is necessary to constantly conduct regular monitoring studies of the health of children, using tests for the content of Hcy in the blood and the state of the folate cycle genes.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124887906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.32402/dovkil2022.03.044
O. Turos, A. Petrosian, N. Brezitska, T. Maremuha, H. Davydenko, L. Mihina, T. Tsarenok
Objective: Risk assessment for the health of the population in Kyiv from air pollution PM2.5. Materials and methods: There were 24826 measurements of PM2.5 obtained at a stationary observation post in Kyiv. Statistical indicators of noncommunicable morbidity in the adult population of Kyiv were used for the analysis. The attributive part of the risk of death and the quantity of attributable deaths were calculated using the software package AirQ +. Results: As a result of studies in Kyiv, the average value of daily concentrations of PM2.5 for 3 years was calculated 21.7 µg/m3. The attributive part of the risk of death among adults aged ≥30 years from lung cancer was determined to be 9.59% and among adults aged ≥25 years from chronic obstructive pulmonary disease to be 9.07%. Attributable deaths that were associated with long-term PM2.5 exposure were: 63 (95% CI: 29-93) deaths from lung cancer and 7 (95% CI: 4-10) deaths from chronic obstructive pulmonary disease. This represents 9.6% and 6.7% of all deaths, respectively.
{"title":"Risk assessment for health of the population in Kyiv from atmospheric air pollution PM2.5","authors":"O. Turos, A. Petrosian, N. Brezitska, T. Maremuha, H. Davydenko, L. Mihina, T. Tsarenok","doi":"10.32402/dovkil2022.03.044","DOIUrl":"https://doi.org/10.32402/dovkil2022.03.044","url":null,"abstract":"Objective: Risk assessment for the health of the population in Kyiv from air pollution PM2.5. Materials and methods: There were 24826 measurements of PM2.5 obtained at a stationary observation post in Kyiv. Statistical indicators of noncommunicable morbidity in the adult population of Kyiv were used for the analysis. The attributive part of the risk of death and the quantity of attributable deaths were calculated using the software package AirQ +. Results: As a result of studies in Kyiv, the average value of daily concentrations of PM2.5 for 3 years was calculated 21.7 µg/m3. The attributive part of the risk of death among adults aged ≥30 years from lung cancer was determined to be 9.59% and among adults aged ≥25 years from chronic obstructive pulmonary disease to be 9.07%. Attributable deaths that were associated with long-term PM2.5 exposure were: 63 (95% CI: 29-93) deaths from lung cancer and 7 (95% CI: 4-10) deaths from chronic obstructive pulmonary disease. This represents 9.6% and 6.7% of all deaths, respectively.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130290678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of work is to study the structure of cancer morbidity in the population of Ukraine living in cities of industrial uranium mining. Materials and methods: Kropyvnytskyi and Kirovohrad oblasts were selected as the scientific basis of the research. Kropyvnytskyi produces uranium raw materials, which are transported to Zhovti Vody, the only city in Ukraine where primary uranium enrichment is carried out. The data of cancer morbidity observations with using materials of the regional center of medical statistics, reports of Kirovohrad regional oncology dispensary, materials «Comprehensive Environmental Protection Program in Kirovohrad region for 2016-2020 years» were used to analyze the environmental and radiation situation. Results: Studies have shown that the concentration of radon in the air of residential buildings, especially one-story, often exceeds the permissible level set for uranium miners. Uranium is also no less harmful to the human body. Enterprises extract uranium ore, carry out its primary processing, and its mines pass simply under residential areas. Radon dissolves quickly in the air, but accumulates in closed, basement areas. Thus, it was found that the main dose a person receives in the premises where the city dweller spends 80% of his time. The content of radon in the indoor air is determined by the specifics of the geological structure of the area, the location on its territory of rock massifs with high uranium content. Conclusions: The analysis of Kirovohrad region’s characteristics shows the effects of radiation in the cancer’s structure. Analyzing the indicators of the Kirovohrad region, we can see the effects of radiation in the structure of the cancer. A large number of houses in Kropyvnytskyi are built of building materials, which include granite with high content of radon and uranium, which negatively affects the health of residents of the city and region. Kropyvnytskyi is one of the three cities in Ukraine with the highest cancer mortality rate. One of the reasons is radon, a colorless, odorless and tasteless gas that is released from faults in the earth's crust and has a significant effect on the appearance of cancerous tumors.
Pub Date : 2022-09-01DOI: 10.32402/dovkil2022.03.023
O. Kapustynska
Environment & Health ISSN: 2077-7477 eISSN: 2077-7485 No: 3 (104) - September, 2022 - Pages: 23-28 Download Full Text (PDF) The state of disability in the adult population evacuated from the 30-km zone of the Chornobyl nuclear power plant due to diseases of the circulatory system Kapustynska O.A.1 1 SI “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Kyiv ABSTRACT: Objective. A key role in assessing the health of the population belongs to disability, given its high prevalence and the variety of socially significant consequences. Research in Ukraine and around the world shows the global prevalence of diseases of the circulatory system (HSC) among the population. The most adverse effects of the Chornobyl disaster on health and social well-being include the disability of the affected population. The aim of the study. To analyze the dynamics of disability indicators in the adult evacuated population due to the leading HSC with an emphasis on the peculiarities of their distribution by groups initially recognized as disabled. Materials and methods. A retrospective analysis of the state of primary disability due to HSC among the adult evacuated population according to the State Register of Ukraine of persons affected by the Chornobyl disaster. Disability analysis was performed according to the data of initially recognized disabled people among the adult evacuated population depending on the time and age at the date of the accident, classes, forms of pathology and groups of persons recognized as disabled. The observation period included 1988–2016. The processing of the obtained data required the formation of a computer database based on Microsoft Excel. Results. According to the analysis, the HSC continues, as in previous post-accident years, to occupy the first place in the structure of the causes of primary disability in the adult evacuated population. Since the accident, the level of disability has increased compared to the early period and reached the highest levels in the late period (2008-2016), regardless of age. In the most remote years since the accident, a significant jump in the level of disability was found in the younger age group of 18-39 years. In the structure of disability in people aged 18-39 in the late period, the first rank is cerebrovascular pathology (CVD), in second place - coronary heart disease (CHD), in third place - hypertension (GC), in people aged 40-60 the first the place belongs to coronary heart disease, the second - GC, the third place - TsVH. In the HSC class, the representatives of both age categories have the second group of disabilities. The results of the research allowed to determine the features and leading HSCs by primary groups of disability. The presence of persons with group III disability implies a high rehabilitation potential and a positive prognosis for their rehabilitation. KEYWORDS: disability, diseases of the circulatory system, evacuated population,
{"title":"The state of disability in the adult population evacuated from the 30-km zone of the Chornobyl nuclear power plant due to diseases of the circulatory system","authors":"O. Kapustynska","doi":"10.32402/dovkil2022.03.023","DOIUrl":"https://doi.org/10.32402/dovkil2022.03.023","url":null,"abstract":"Environment & Health ISSN: 2077-7477 eISSN: 2077-7485 No: 3 (104) - September, 2022 - Pages: 23-28 Download Full Text (PDF) The state of disability in the adult population evacuated from the 30-km zone of the Chornobyl nuclear power plant due to diseases of the circulatory system Kapustynska O.A.1 1 SI “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Kyiv ABSTRACT: Objective. A key role in assessing the health of the population belongs to disability, given its high prevalence and the variety of socially significant consequences. Research in Ukraine and around the world shows the global prevalence of diseases of the circulatory system (HSC) among the population. The most adverse effects of the Chornobyl disaster on health and social well-being include the disability of the affected population. The aim of the study. To analyze the dynamics of disability indicators in the adult evacuated population due to the leading HSC with an emphasis on the peculiarities of their distribution by groups initially recognized as disabled. Materials and methods. A retrospective analysis of the state of primary disability due to HSC among the adult evacuated population according to the State Register of Ukraine of persons affected by the Chornobyl disaster. Disability analysis was performed according to the data of initially recognized disabled people among the adult evacuated population depending on the time and age at the date of the accident, classes, forms of pathology and groups of persons recognized as disabled. The observation period included 1988–2016. The processing of the obtained data required the formation of a computer database based on Microsoft Excel. Results. According to the analysis, the HSC continues, as in previous post-accident years, to occupy the first place in the structure of the causes of primary disability in the adult evacuated population. Since the accident, the level of disability has increased compared to the early period and reached the highest levels in the late period (2008-2016), regardless of age. In the most remote years since the accident, a significant jump in the level of disability was found in the younger age group of 18-39 years. In the structure of disability in people aged 18-39 in the late period, the first rank is cerebrovascular pathology (CVD), in second place - coronary heart disease (CHD), in third place - hypertension (GC), in people aged 40-60 the first the place belongs to coronary heart disease, the second - GC, the third place - TsVH. In the HSC class, the representatives of both age categories have the second group of disabilities. The results of the research allowed to determine the features and leading HSCs by primary groups of disability. The presence of persons with group III disability implies a high rehabilitation potential and a positive prognosis for their rehabilitation. KEYWORDS: disability, diseases of the circulatory system, evacuated population, ","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125488135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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