Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2024.11.006
Rebecca T. Hahn MD , Philippe Pibarot DVM, PhD , Amr Abbas MD , Raj Makkar MD , Vinod H. Thourani MD , Philippe Généreux MD , Susheel Kodali MD , Samir Kapadia MD , Vasilis Babaliaros MD , Julien Ternacle MD, PhD , Alexis Theron MD, PhD , Nicole Cristell MD , Sarah Clarke DNP , Yanglu Zhao MD, PhD , Maria Alu MS , Mahesh V. Madhavan MD, MS , David J. Cohen MD, MSc , Jonathon Leipsic MD , John Webb MD , Michael J. Mack MD , Martin B. Leon MD
Background
Short-term clinical outcomes after transcatheter aortic valve replacement (TAVR) are similar in individuals with small or large annuli. The longer term impact of prosthesis-patient mismatch (PPM) and mean gradient (MG) post-TAVR in these patients remains controversial.
Objectives
The aim of this study was to investigate 5-year outcomes in patients with small vs large annuli.
Methods
Patients from the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 intermediate-risk registry and the PARTNER 3 low-risk randomized controlled trial were grouped according to small (≤430 mm2) or large (>430 mm2) annular size. The primary endpoint was a composite of all-cause death, disabling stroke, or heart failure hospitalization. In addition, the relationships between both PPM and post-TAVR MG and clinical outcomes were analyzed.
Results
In total, 1,355 patients were included: 476 with small annuli (376.7 ± 41.9 mm2) and 879 with large annuli (518.3 ± 58.0 mm2). Patients with small annuli were older (age 79.6 ± 7.1 years vs 78.7 ± 7.8 years; P = 0.047), were more often female (75.0% vs 16.2%; P < 0.0001), had higher baseline Society of Thoracic Surgeons scores (4.3% ± 1.93% vs 4.0% ± 1.93%; P < 0.0001), and had higher left ventricular ejection fractions (66.3% ± 15.82% vs 59.7% ± 13.68%; P < 0.0001). Primary endpoint rates were similar at 1 year (7.8% vs 8.0%; P = 0.94) and 5 years (36.3% vs 35.8%; P = 0.83). Bioprosthetic valve failure was infrequent at 5 years in both groups (2.9% vs 2.1%; P = 0.46). Among female patients, outcomes were similar for small vs large annuli (primary endpoint; 33.6% vs 34.2%; P = 0.90). Among patients with small annuli, there was no association between 5-year outcomes and any severity of PPM (P = 0.22) or 30-day MG (P for nonlinearity = 0.96).
Conclusions
Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.
{"title":"Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli","authors":"Rebecca T. Hahn MD , Philippe Pibarot DVM, PhD , Amr Abbas MD , Raj Makkar MD , Vinod H. Thourani MD , Philippe Généreux MD , Susheel Kodali MD , Samir Kapadia MD , Vasilis Babaliaros MD , Julien Ternacle MD, PhD , Alexis Theron MD, PhD , Nicole Cristell MD , Sarah Clarke DNP , Yanglu Zhao MD, PhD , Maria Alu MS , Mahesh V. Madhavan MD, MS , David J. Cohen MD, MSc , Jonathon Leipsic MD , John Webb MD , Michael J. Mack MD , Martin B. Leon MD","doi":"10.1016/j.jcin.2024.11.006","DOIUrl":"10.1016/j.jcin.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Short-term clinical outcomes after transcatheter aortic valve replacement (TAVR) are similar in individuals with small or large annuli. The longer term impact of prosthesis-patient mismatch (PPM) and mean gradient (MG) post-TAVR in these patients remains controversial.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate 5-year outcomes in patients with small vs large annuli.</div></div><div><h3>Methods</h3><div>Patients from the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 intermediate-risk registry and the PARTNER 3 low-risk randomized controlled trial were grouped according to small (≤430 mm<sup>2</sup>) or large (>430 mm<sup>2</sup>) annular size. The primary endpoint was a composite of all-cause death, disabling stroke, or heart failure hospitalization. In addition, the relationships between both PPM and post-TAVR MG and clinical outcomes were analyzed.</div></div><div><h3>Results</h3><div>In total, 1,355 patients were included: 476 with small annuli (376.7 ± 41.9 mm<sup>2</sup>) and 879 with large annuli (518.3 ± 58.0 mm<sup>2</sup>). Patients with small annuli were older (age 79.6 ± 7.1 years vs 78.7 ± 7.8 years; <em>P</em> = 0.047), were more often female (75.0% vs 16.2%; <em>P</em> < 0.0001), had higher baseline Society of Thoracic Surgeons scores (4.3% ± 1.93% vs 4.0% ± 1.93%; <em>P</em> < 0.0001), and had higher left ventricular ejection fractions (66.3% ± 15.82% vs 59.7% ± 13.68%; <em>P</em> < 0.0001). Primary endpoint rates were similar at 1 year (7.8% vs 8.0%; <em>P</em> = 0.94) and 5 years (36.3% vs 35.8%; <em>P</em> = 0.83). Bioprosthetic valve failure was infrequent at 5 years in both groups (2.9% vs 2.1%; <em>P</em> = 0.46). Among female patients, outcomes were similar for small vs large annuli (primary endpoint; 33.6% vs 34.2%; <em>P</em> = 0.90). Among patients with small annuli, there was no association between 5-year outcomes and any severity of PPM (<em>P</em> = 0.22) or 30-day MG (<em>P</em> for nonlinearity = 0.96).</div></div><div><h3>Conclusions</h3><div>Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 506-517"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since its inception, percutaneous coronary intervention (PCI) has relied upon vessel opacification with iodinated contrast to plan, guide, and assess the results of the procedure. Yet revisiting this fundamental concept is important in contemporary PCI practice, especially in patients with high-risk clinical or anatomical profiles. In addition to decreasing the probability of acute kidney injury during PCI, limiting the volume of iodinated contrast allows the operator to perform more thorough interventions by relying on intracoronary imaging and physiology, ultimately contributing to more complete revascularization and improving the efficacy and durability of the intervention. Ultra-low-contrast PCI (ULCPCI) may thus be useful in performing PCI not only in patients with chronic renal dysfunction but also in those with multivessel coronary artery disease, impaired left ventricular function, and many other scenarios. The aim of this review is to highlight contemporary PCI scenarios in which a ULCPCI approach may be beneficial. The authors provide a structured approach to address the challenges faced by operators in transitioning from conventional contrast-based interventions to ULCPCI, with practical solutions that are accessible to most interventionalists. The reader will learn that ULCPCI is feasible in contemporary practice as a result of technological innovation, the implementation of dedicated skills, and redefining the role of angiography as the cornerstone of contemporary PCI.
{"title":"Ultra-Low-Contrast PCI","authors":"Asad Shabbir MD, PhD , Ziad Ali MD, DPhil , Giuseppe Colletti MD , Dariusz Dudek MD, PhD , Roberto Garbo MD , Farrel Hellig MD, PhD , Jeffrey Moses MD , Abdul Mozid MD , Sunao Nakamura MD, PhD , Billal Patel MD , Gabor G. Toth MD, PhD , Nattawut Wongpraparut MD , Nieves Gonzalo MD, PhD , Javier Escaned MD, PhD","doi":"10.1016/j.jcin.2024.11.043","DOIUrl":"10.1016/j.jcin.2024.11.043","url":null,"abstract":"<div><div>Since its inception, percutaneous coronary intervention (PCI) has relied upon vessel opacification with iodinated contrast to plan, guide, and assess the results of the procedure. Yet revisiting this fundamental concept is important in contemporary PCI practice, especially in patients with high-risk clinical or anatomical profiles. In addition to decreasing the probability of acute kidney injury during PCI, limiting the volume of iodinated contrast allows the operator to perform more thorough interventions by relying on intracoronary imaging and physiology, ultimately contributing to more complete revascularization and improving the efficacy and durability of the intervention. Ultra-low-contrast PCI (ULCPCI) may thus be useful in performing PCI not only in patients with chronic renal dysfunction but also in those with multivessel coronary artery disease, impaired left ventricular function, and many other scenarios. The aim of this review is to highlight contemporary PCI scenarios in which a ULCPCI approach may be beneficial. The authors provide a structured approach to address the challenges faced by operators in transitioning from conventional contrast-based interventions to ULCPCI, with practical solutions that are accessible to most interventionalists. The reader will learn that ULCPCI is feasible in contemporary practice as a result of technological innovation, the implementation of dedicated skills, and redefining the role of angiography as the cornerstone of contemporary PCI.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 409-424"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.037
Desmond Boakye Tanoh , Arjun Nair , Lindon Young
{"title":"100.22 Prevention Over Cure: The Role of PKCε in Mitigating Post-Myocardial Infarction Heart Failure","authors":"Desmond Boakye Tanoh , Arjun Nair , Lindon Young","doi":"10.1016/j.jcin.2025.01.037","DOIUrl":"10.1016/j.jcin.2025.01.037","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S9"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.026
Seung-Woon Rha , Se Yeon Choi , Jinah Cha , Byoung Geol Choi , Woo Jin Ahn , Wonsang Chu , Soohyung Park , Ji Young Park , Cheol Ung Choi , Chang Gyu Park
{"title":"100.46 Comparison of Clinical Outcomes Between Second Generation Drug-Eluting Stents in Acute Myocardial Infarction Patients: 10-Year Follow-Up Results","authors":"Seung-Woon Rha , Se Yeon Choi , Jinah Cha , Byoung Geol Choi , Woo Jin Ahn , Wonsang Chu , Soohyung Park , Ji Young Park , Cheol Ung Choi , Chang Gyu Park","doi":"10.1016/j.jcin.2025.01.026","DOIUrl":"10.1016/j.jcin.2025.01.026","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S6"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}