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Optimizing Outcomes in Non–ST-Segment Elevation Myocardial Infarction With Angiography-Derived Index of Microcirculatory Resistance 利用血管造影得出的微循环阻力指数优化非 ST 段抬高型心肌梗死的预后。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.09.014
Ikshita Sabharwal MBBS, Jaimin Trivedi MBBS
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引用次数: 0
Surgical vs Transcatheter Treatment in Patients With Coronary Artery Disease and Severe Aortic Stenosis 冠状动脉疾病和严重主动脉瓣狭窄患者的手术治疗与经导管治疗的比较
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.09.003
Ignacio J. Amat-Santos MD, PhD , Mario García-Gómez MD , Pablo Avanzas MD, PhD , Víctor Jiménez-Diaz MD , Juan H. Alonso-Briales MD , José M. de la Torre Hernández MD , Jorge Sanz-Sánchez MD , José Antonio Diarte-de Miguel MD , Ángel Sánchez-Recalde MD , Luis Nombela-Franco MD, PhD , Jesús Jiménez-Mazuecos MD , Vicenç Serra MD , Juan Manuel Nogales-Asensio MD , Sergio García-Blas MD , Antonio Gómez-Menchero MD , Raquel del Valle MD, PhD , Carolina Mayor Déniz MD , Walid Al Houssaini MD , Gabriela Veiga-Fernández MD, PhD , José Luis Diez-Gil MD , J. Alberto San Román MD, PhD

Background

Severe aortic stenosis (AS) coexists with coronary artery disease (CAD) in approximately 50% of patients. The preferred treatment is combined surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG). However, transcatheter aortic valve replacement (TAVR) along with percutaneous coronary intervention (PCI) has emerged as a viable alternative.

Objectives

This study sought to compare the outcomes of PCI + TAVR vs CABG + SAVR.

Methods

This national multicenter retrospective study in Spain involved patients with severe AS and CAD treated between 2018 and 2021. Patients underwent either PCI + TAVR or CABG + SAVR and were compared. The primary endpoint was all-cause mortality and stroke at 1 year. Propensity score analysis was performed to mitigate baseline differences.

Results

Of the 1,342 included patients, 625 (46.6%) underwent PCI + TAVR, and 713 (53.1%) underwent CABG + SAVR. Patients in the percutaneous arm were older (age 81.6 ± 5.8 years vs 72.1 ± 7 years; P < 0.001), had a higher prevalence of chronic kidney disease (40.6% vs 14.9%; P < 0.001), and had higher Society of Thoracic Surgeons risk scores (4.3% [interquartile range (Q1-Q3): 2.8-6.4] vs 2.2% [Q1-Q3: 1.4-3.3]; P < 0.001). Technical success rates were 96% for PCI + TAVR and 98.4% for CABG + SAVR (P = 0.008), with similar periprocedural mortality (0.8% vs 0.7%; P = 0.999). However, the mortality + stroke rate at 30 days was higher in the CABG + SAVR group compared with PCI + TAVR, both in the unmatched (12.2% vs 4.7%; P = 0.005) and matched cohorts (8.8% vs 4.5%; P = 0.002), persisting at the 1-year follow-up.

Conclusions

Despite a lower baseline risk, CABG + SAVR in patients with severe AS and CAD was associated with a higher rate of death and stroke compared with PCI + TAVR, highlighting the necessity for a large, randomized analysis.
背景:约有 50% 的患者同时患有严重的主动脉瓣狭窄 (AS) 和冠状动脉疾病 (CAD)。首选的治疗方法是外科主动脉瓣置换术(SAVR)和冠状动脉旁路移植术(CABG)。然而,经导管主动脉瓣置换术(TAVR)和经皮冠状动脉介入治疗(PCI)已成为一种可行的替代方法:本研究旨在比较 PCI + TAVR 与 CABG + SAVR 的疗效:这项西班牙全国多中心回顾性研究涉及在2018年至2021年间接受治疗的严重AS和CAD患者。患者接受了 PCI + TAVR 或 CABG + SAVR,并进行了比较。主要终点是1年内的全因死亡率和中风。为减少基线差异,进行了倾向评分分析:在纳入的 1342 例患者中,625 例(46.6%)接受了 PCI + TAVR,713 例(53.1%)接受了 CABG + SAVR。经皮治疗组的患者年龄更大(81.6 ± 5.8 岁 vs 72.1 ± 7 岁;P < 0.001),慢性肾脏病患病率更高(40.6% vs 14.9%;P < 0.001),胸外科医师协会风险评分更高(4.3% [四分位间范围(Q1-Q3):2.8-6.4] vs 2.2% [Q1-Q3:1.4-3.3];P < 0.001)。PCI+TAVR的技术成功率为96%,CABG+SAVR为98.4%(P = 0.008),围手术期死亡率相似(0.8% vs 0.7%;P = 0.999)。然而,与PCI + TAVR相比,CABG + SAVR组在30天内的死亡率+卒中率更高,无论是在未配对队列(12.2% vs 4.7%;P = 0.005)还是配对队列(8.8% vs 4.5%;P = 0.002)中都是如此,并且在1年随访中持续存在:尽管基线风险较低,但与 PCI + TAVR 相比,重度 AS 和 CAD 患者的 CABG + SAVR 与较高的死亡和卒中发生率相关,因此有必要进行大规模随机分析。
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引用次数: 0
Combined Impact of Residual Mitral Regurgitation and Gradient After Mitral Valve Transcatheter Edge-to-Edge Repair 二尖瓣经导管边缘到边缘修复术后二尖瓣残余反流和瓣坡的综合影响
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.08.004
Gagan D. Singh MD , Matthew J. Price MD , Mony Shuvy MD , Jason H. Rogers MD , Carmelo Grasso MD , Francesco Bedogni MD , Federico Asch MD , José L. Zamorano MD , Melody Dong PhD , Kelli Peterman MPH , Evelio Rodriguez MD , Saibal Kar MD , Ralph Stephan von Bardeleben MD , Francesco Maisano MD

Background

Reducing mitral regurgitation (MR) during mitral transcatheter edge-to-edge repair (M-TEER) may come at the cost of increased mitral valve gradient (MVG). The combined impact of residual MR and MVG on clinical outcomes after M-TEER is unknown.

Objectives

This study sought to evaluate the impact of postprocedure MR and MVG on clinical outcomes after M-TEER.

Methods

EXPANDed is a pooled, patient-level cohort of the EXPAND (A Contemporary, Prospective Study Evaluating Real-world Experience of Performance and Safety for the Next Generation of MitraClip Devices) and EXPAND G4 studies, which were designed to evaluate real-world safety and effectiveness of the third- and fourth-generation MitraClip TEER Systems. Subjects were categorized by echocardiographic core laboratory (ECL) assessments into 4 groups according to 30-day MR grade and mean MVG: 1) MR ≤1+/MVG <5 mm Hg; 2) MR ≤1+/MVG ≥5 mm Hg; 3) MR ≥2+/MVG <5 mm Hg; and 4) MR ≥2+/MVG ≥5 mm Hg.

Results

A total of 1,723 subjects had evaluable echocardiograms at 30 days: 72% had MR ≤1+/MVG <5 mm Hg, 18% had MR ≤1+/MVG ≥5 mm Hg, 7% had MR ≥2+/MVG <5 mm Hg, and 3% had MR ≥2+/MVG ≥5 mm Hg. MR≤1+ was sustained through 1 year in 93% of patients who achieved 30-day MR≤1+. MVG decreased from 30 days to 1 year in subjects with MVG ≥5 mm Hg (6.7 ± 4.0 to 5.5 ± 2.5 mm Hg MR ≤1+/MVG ≥5 mm Hg and 6.5 ± 1.5 to 5.5 ± 1.7 mm Hg MR ≥2+/MVG ≥5 mm Hg). One-year rates of all-cause mortality and heart failure hospitalization were lower for subjects who achieved MR ≤1+ at 30 days, regardless of MVG.

Conclusions

Reduction of MR to mild or less after M-TEER with the latest-generation MitraClip systems was associated with clinical benefit regardless of MVG.
背景:在二尖瓣经导管边缘到边缘修补术(M-TEER)中减少二尖瓣反流(MR)可能要以增加二尖瓣瓣膜梯度(MVG)为代价。残余 MR 和 MVG 对 M-TEER 后临床结果的综合影响尚不清楚:本研究旨在评估术后 MR 和 MVG 对 M-TEER 后临床预后的影响:EXPANDed是EXPAND(评估下一代MitraClip设备性能和安全性真实世界经验的当代前瞻性研究)和EXPAND G4研究的汇总患者队列,这两项研究旨在评估第三代和第四代MitraClip TEER系统的真实世界安全性和有效性。根据超声心动图核心实验室(ECL)的评估结果,受试者按30天MR分级和平均MVG分为4组:1)MR≤1+/MVG 结果:共有 1,723 名受试者在 30 天内接受了可评估的超声心动图检查:72% 的受试者 MR ≤1+/MVG:无论MVG如何,使用最新一代MitraClip系统进行M-TEER后将MR降至轻度或轻度以下与临床获益相关。
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引用次数: 0
Moving Toward a Better Understanding of Functional Mitral Regurgitation With Preserved Left Ventricular Function 更好地理解左心室功能保留的功能性二尖瓣反流
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.09.054
Xavier Freixa MD, PhD, Andrea Ruberti MD, Ander Regueiro MD, PhD, Laura Sanchis MD, PhD
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引用次数: 0
It Is Time to Tighten the Screws! 是时候拧紧螺丝了!
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.08.039
Steven J. Yakubov MD, Carlos Sanchez MD
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引用次数: 0
Decision-Making Approach to the Treatment of Young and Low-Risk Patients With Aortic Stenosis 治疗年轻、低风险主动脉瓣狭窄患者的决策方法。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.08.032
Tanush Gupta MD , S. Chris Malaisrie MD , Wayne Batchelor MD , Konstantinos Dean Boudoulas MD , Laura Davidson MD , Uzoma N. Ibebuogu MD , Jacques Kpodonu MD , Ramesh Singh MD , Ibrahim Sultan MD , Misty Theriot BSN , Michael J. Reardon MD , Martin B. Leon MD , Kendra J. Grubb MD, MHA , A Perspective From the American College of Cardiology Cardiac Surgery Team and Interventional Cardiology Councils
Over a decade of randomized controlled trial data demonstrate excellent outcomes with transcatheter aortic valve replacement or surgical aortic valve replacement for patients with symptomatic severe aortic stenosis regardless of surgical risk. The 2020 American College of Cardiology/American Heart Association guidelines recommend both options for low-risk AS patients aged 65 to 80 years. However, the fastest growing population of patients receiving transcatheter aortic valve replacement in the United States is <65 years old, with little data to support the practice. The American College of Cardiology’s Cardiac Surgery Team Section Leadership and Interventional Cardiology Councils, a multidisciplinary collaboration of cardiologists and cardiac surgeons, sought to summarize the relevant data into a decision-making tool for heart valve teams. A literature review was completed, and guidelines, randomized controlled trials, and large observational studies were summarized into a pragmatic decision-making approach to treating young and low-risk patients with AS.
十多年来的随机对照试验数据表明,对于有症状的重度主动脉瓣狭窄患者,无论手术风险如何,经导管主动脉瓣置换术或手术主动脉瓣置换术都能取得极佳的疗效。2020 年美国心脏病学会/美国心脏协会指南推荐 65 至 80 岁的低风险主动脉瓣狭窄患者选择这两种方法。然而,在美国,接受经导管主动脉瓣置换术的患者中增长最快的人群是
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引用次数: 0
Timing of Aortic Valve Intervention in the Management of Aortic Stenosis 主动脉瓣介入治疗主动脉瓣狭窄的时机。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.08.046
Annette Maznyczka MD, PhD, MSc , Bernard Prendergast MD , Marc Dweck MD, PhD , Stephan Windecker MD , Philippe Généreux MD , David Hildick-Smith MD , Jeroen Bax MD, PhD , Thomas Pilgrim MD, MSc
Aortic stenosis (AS) affects about 12% of people aged ≥75 years. Accumulating evidence on the prognostic importance of cardiac damage in patients with asymptomatic and less than severe AS supports the proposition of advancing aortic valve replacement (AVR) to earlier disease stages. Potential benefits of earlier treatment, including prevention of cardiac damage progression and reduced cardiovascular hospitalizations, need to be balanced against the earlier procedural risk and subsequent lifetime management after AVR. Two small, randomized trials indicate that early surgical AVR may improve survival in patients with asymptomatic severe AS, and observational data suggest that AVR may reduce mortality even in patients with moderate AS. A clear understanding of the pathophysiology of cardiac damage secondary to AS is needed to develop strategies to select patients for earlier AVR. Noninvasive imaging can detect early cardiac damage, and indices such as fibrosis, global longitudinal strain, and myocardial work index have potential use to guide stratification of patients for earlier AVR. Ongoing randomized trials are investigating the safety and efficacy of AVR for patients with asymptomatic severe AS and those with moderate AS who have symptoms/evidence of cardiac damage. Pathophysiological considerations and accumulating evidence from clinical studies that support earlier timing of AVR for AS will need to be corroborated by the results of these trials. This review aims to evaluate the evidence for earlier AVR, discuss strategies to guide stratification of patients who may benefit from this approach, highlight the relevant ongoing randomized trials, and consider the consequences of earlier intervention.
在年龄≥75 岁的人群中,约有 12% 的人患有主动脉瓣狭窄(AS)。越来越多的证据表明,无症状和不太严重的主动脉瓣狭窄患者的心脏损伤对预后非常重要,这支持了将主动脉瓣置换术(AVR)提前到疾病早期阶段的主张。早期治疗的潜在益处(包括预防心脏损伤进展和减少心血管疾病住院治疗)需要与早期手术风险和主动脉瓣置换术后的终生管理相平衡。两项小型随机试验表明,早期手术自动脉翻转术可提高无症状重度 AS 患者的生存率,而观察数据表明,即使是中度 AS 患者,自动脉翻转术也可降低死亡率。需要清楚了解继发于 AS 的心脏损伤的病理生理学,以制定选择患者进行早期 AVR 的策略。无创成像可检测早期心脏损伤,纤维化、整体纵向应变和心肌功指数等指标可用于指导对患者进行分层,以便尽早进行房室重建。目前正在进行的随机试验正在研究对无症状的重度 AS 患者和有心脏损伤症状/证据的中度 AS 患者进行 AVR 的安全性和有效性。病理生理学方面的考虑因素和临床研究积累的证据支持尽早对强直性脊柱炎患者进行体外反搏术,但还需要这些试验结果的证实。本综述旨在评估早期房室重建的证据,讨论指导对可能从这种方法中获益的患者进行分层的策略,强调正在进行的相关随机试验,并考虑早期干预的后果。
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引用次数: 0
Radiation Exposure 辐射暴露:病人和医生共同承担的风险。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.09.012
Sunil V. Rao MD, Johanna Ben-Ami Lerner MD
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引用次数: 0
Institutional Variation in Patient Radiation Doses During Transcatheter Valve Interventions 经导管瓣膜介入术中患者辐射剂量的机构差异:全州经验。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.08.048
David A. McNamara MD, MPH , Jeremy Albright PhD , Devraj Sukul MD , Stanley Chetcuti MD , Annemarie Forrest MS, MPH , Paul Grossman MD , Raed M. Alnajjar MD , Himanshu Patel MD , Hitinder S. Gurm MBBS , Ryan D. Madder MD

Background

Little is known about institutional radiation doses during transcatheter valve interventions.

Objectives

The authors sought to evaluate institutional variability in radiation doses during transcatheter valve interventions.

Methods

Using a large statewide registry, transcatheter edge-to-edge mitral valve repair, transcatheter mitral valve replacement, and transcatheter aortic valve replacement procedures between January 1, 2020, and December 31, 2022, with an air kerma (AK) recorded were analyzed. Patient and procedural characteristics were compared between cases with AK ≥2 and <2 Gy. Associations of variables with AK ≥2 Gy were investigated using Bayesian random effects modeling and median ORs for the performing hospital.

Results

Among 9,446 procedures across 30 hospitals, median (Q1-Q3) procedural AK was 0.592 Gy (0.348-0.989 Gy) with AK ≥2 Gy in 533 cases (5.6%). Wide variation in procedural AK was observed, with an institutional frequency of AK ≥2 Gy ranging from 0.0% to 29.5%. Bayesian modeling identified the performing hospital as more strongly associated with the odds of a procedural AK ≥2 Gy than any patient or procedural factors (hospital median OR: 3.54 [95% credible interval: 2.52-16.66]).

Conclusions

In a large, multicenter state-wide registry, there is wide institutional variability in patient-level radiation doses during transcatheter valve interventions, with the performing hospital having a higher odds of an AK ≥2 Gy than any patient or procedural factors. Future interventions are warranted to reduce procedural-related variation in radiation exposure.
背景:人们对经导管瓣膜介入治疗过程中的机构辐射剂量知之甚少:作者试图评估经导管瓣膜介入治疗过程中机构辐射剂量的可变性:利用全州范围内的大型登记册,对 2020 年 1 月 1 日至 2022 年 12 月 31 日期间记录有空气切迹(AK)的经导管二尖瓣边缘到边缘修补术、经导管二尖瓣置换术和经导管主动脉瓣置换术进行了分析。比较了AK≥2的病例和AK≥2的病例的患者和手术特征:在30家医院的9446例手术中,手术AK的中位数(Q1-Q3)为0.592 Gy(0.348-0.989 Gy),AK≥2 Gy的病例有533例(5.6%)。术中 AK 的差异很大,AK ≥2 Gy 的机构频率从 0.0% 到 29.5% 不等。贝叶斯模型发现,与患者或手术因素相比,手术医院与手术AK≥2 Gy的几率关系更大(医院中位OR:3.54 [95%可信区间:2.52-16.66]):在一个大型、多中心、全州范围的登记中,经导管瓣膜介入治疗过程中患者水平的辐射剂量存在很大的机构差异,与任何患者或手术因素相比,进行手术的医院发生AK≥2 Gy的几率更高。未来有必要采取干预措施,以减少与手术相关的辐射暴露差异。
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引用次数: 0
Prosthesis-Patient Mismatch Post-TAVR TAVR术后假体与患者的不匹配:对动态事物的僵化解读。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-11 DOI: 10.1016/j.jcin.2024.09.015
Anirudh Kumar MD, MSc, Imran Ahmad MD, Arun Kanmanthareddy MD, Hemal Gada MD
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引用次数: 0
期刊
JACC. Cardiovascular interventions
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