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JACC. Cardiovascular interventions最新文献

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Low-Gradient Severe Aortic Stenosis Is Not Mainstream 低梯度严重主动脉瓣狭窄不是主流:来自当前AS注册的见解-2。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.10.039
Marie-Annick Clavel DVM, PhD, Paolo Springhetti MD, Philippe Pibarot DVM, PhD
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引用次数: 0
Prosthesis-Patient Mismatch in Patients With Bicuspid Aortic Valve 二尖瓣主动脉瓣患者假体-患者不匹配。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.10.038
David Messika-Zeitoun MD, PhD, Ian G. Burwash MD
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引用次数: 0
100.24 ABSTRACT WITHDRAWN
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.068
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引用次数: 0
Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.11.006
Rebecca T. Hahn MD , Philippe Pibarot DVM, PhD , Amr Abbas MD , Raj Makkar MD , Vinod H. Thourani MD , Philippe Généreux MD , Susheel Kodali MD , Samir Kapadia MD , Vasilis Babaliaros MD , Julien Ternacle MD, PhD , Alexis Theron MD, PhD , Nicole Cristell MD , Sarah Clarke DNP , Yanglu Zhao MD, PhD , Maria Alu MS , Mahesh V. Madhavan MD, MS , David J. Cohen MD, MSc , Jonathon Leipsic MD , John Webb MD , Michael J. Mack MD , Martin B. Leon MD

Background

Short-term clinical outcomes after transcatheter aortic valve replacement (TAVR) are similar in individuals with small or large annuli. The longer term impact of prosthesis-patient mismatch (PPM) and mean gradient (MG) post-TAVR in these patients remains controversial.

Objectives

The aim of this study was to investigate 5-year outcomes in patients with small vs large annuli.

Methods

Patients from the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 intermediate-risk registry and the PARTNER 3 low-risk randomized controlled trial were grouped according to small (≤430 mm2) or large (>430 mm2) annular size. The primary endpoint was a composite of all-cause death, disabling stroke, or heart failure hospitalization. In addition, the relationships between both PPM and post-TAVR MG and clinical outcomes were analyzed.

Results

In total, 1,355 patients were included: 476 with small annuli (376.7 ± 41.9 mm2) and 879 with large annuli (518.3 ± 58.0 mm2). Patients with small annuli were older (age 79.6 ± 7.1 years vs 78.7 ± 7.8 years; P = 0.047), were more often female (75.0% vs 16.2%; P < 0.0001), had higher baseline Society of Thoracic Surgeons scores (4.3% ± 1.93% vs 4.0% ± 1.93%; P < 0.0001), and had higher left ventricular ejection fractions (66.3% ± 15.82% vs 59.7% ± 13.68%; P < 0.0001). Primary endpoint rates were similar at 1 year (7.8% vs 8.0%; P = 0.94) and 5 years (36.3% vs 35.8%; P = 0.83). Bioprosthetic valve failure was infrequent at 5 years in both groups (2.9% vs 2.1%; P = 0.46). Among female patients, outcomes were similar for small vs large annuli (primary endpoint; 33.6% vs 34.2%; P = 0.90). Among patients with small annuli, there was no association between 5-year outcomes and any severity of PPM (P = 0.22) or 30-day MG (P for nonlinearity = 0.96).

Conclusions

Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.
{"title":"Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli","authors":"Rebecca T. Hahn MD ,&nbsp;Philippe Pibarot DVM, PhD ,&nbsp;Amr Abbas MD ,&nbsp;Raj Makkar MD ,&nbsp;Vinod H. Thourani MD ,&nbsp;Philippe Généreux MD ,&nbsp;Susheel Kodali MD ,&nbsp;Samir Kapadia MD ,&nbsp;Vasilis Babaliaros MD ,&nbsp;Julien Ternacle MD, PhD ,&nbsp;Alexis Theron MD, PhD ,&nbsp;Nicole Cristell MD ,&nbsp;Sarah Clarke DNP ,&nbsp;Yanglu Zhao MD, PhD ,&nbsp;Maria Alu MS ,&nbsp;Mahesh V. Madhavan MD, MS ,&nbsp;David J. Cohen MD, MSc ,&nbsp;Jonathon Leipsic MD ,&nbsp;John Webb MD ,&nbsp;Michael J. Mack MD ,&nbsp;Martin B. Leon MD","doi":"10.1016/j.jcin.2024.11.006","DOIUrl":"10.1016/j.jcin.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Short-term clinical outcomes after transcatheter aortic valve replacement (TAVR) are similar in individuals with small or large annuli. The longer term impact of prosthesis-patient mismatch (PPM) and mean gradient (MG) post-TAVR in these patients remains controversial.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate 5-year outcomes in patients with small vs large annuli.</div></div><div><h3>Methods</h3><div>Patients from the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 intermediate-risk registry and the PARTNER 3 low-risk randomized controlled trial were grouped according to small (≤430 mm<sup>2</sup>) or large (&gt;430 mm<sup>2</sup>) annular size. The primary endpoint was a composite of all-cause death, disabling stroke, or heart failure hospitalization. In addition, the relationships between both PPM and post-TAVR MG and clinical outcomes were analyzed.</div></div><div><h3>Results</h3><div>In total, 1,355 patients were included: 476 with small annuli (376.7 ± 41.9 mm<sup>2</sup>) and 879 with large annuli (518.3 ± 58.0 mm<sup>2</sup>). Patients with small annuli were older (age 79.6 ± 7.1 years vs 78.7 ± 7.8 years; <em>P</em> = 0.047), were more often female (75.0% vs 16.2%; <em>P</em> &lt; 0.0001), had higher baseline Society of Thoracic Surgeons scores (4.3% ± 1.93% vs 4.0% ± 1.93%; <em>P</em> &lt; 0.0001), and had higher left ventricular ejection fractions (66.3% ± 15.82% vs 59.7% ± 13.68%; <em>P</em> &lt; 0.0001). Primary endpoint rates were similar at 1 year (7.8% vs 8.0%; <em>P</em> = 0.94) and 5 years (36.3% vs 35.8%; <em>P</em> = 0.83). Bioprosthetic valve failure was infrequent at 5 years in both groups (2.9% vs 2.1%; <em>P</em> = 0.46). Among female patients, outcomes were similar for small vs large annuli (primary endpoint; 33.6% vs 34.2%; <em>P</em> = 0.90). Among patients with small annuli, there was no association between 5-year outcomes and any severity of PPM (<em>P</em> = 0.22) or 30-day MG (<em>P</em> for nonlinearity = 0.96).</div></div><div><h3>Conclusions</h3><div>Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 506-517"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Echo-Derived Gradients
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.12.007
Amit N. Vora MD, MPH , John K. Forrest MD , Amar Krishnaswamy MD
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引用次数: 0
Ultra-Low-Contrast PCI
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.11.043
Asad Shabbir MD, PhD , Ziad Ali MD, DPhil , Giuseppe Colletti MD , Dariusz Dudek MD, PhD , Roberto Garbo MD , Farrel Hellig MD, PhD , Jeffrey Moses MD , Abdul Mozid MD , Sunao Nakamura MD, PhD , Billal Patel MD , Gabor G. Toth MD, PhD , Nattawut Wongpraparut MD , Nieves Gonzalo MD, PhD , Javier Escaned MD, PhD
Since its inception, percutaneous coronary intervention (PCI) has relied upon vessel opacification with iodinated contrast to plan, guide, and assess the results of the procedure. Yet revisiting this fundamental concept is important in contemporary PCI practice, especially in patients with high-risk clinical or anatomical profiles. In addition to decreasing the probability of acute kidney injury during PCI, limiting the volume of iodinated contrast allows the operator to perform more thorough interventions by relying on intracoronary imaging and physiology, ultimately contributing to more complete revascularization and improving the efficacy and durability of the intervention. Ultra-low-contrast PCI (ULCPCI) may thus be useful in performing PCI not only in patients with chronic renal dysfunction but also in those with multivessel coronary artery disease, impaired left ventricular function, and many other scenarios. The aim of this review is to highlight contemporary PCI scenarios in which a ULCPCI approach may be beneficial. The authors provide a structured approach to address the challenges faced by operators in transitioning from conventional contrast-based interventions to ULCPCI, with practical solutions that are accessible to most interventionalists. The reader will learn that ULCPCI is feasible in contemporary practice as a result of technological innovation, the implementation of dedicated skills, and redefining the role of angiography as the cornerstone of contemporary PCI.
{"title":"Ultra-Low-Contrast PCI","authors":"Asad Shabbir MD, PhD ,&nbsp;Ziad Ali MD, DPhil ,&nbsp;Giuseppe Colletti MD ,&nbsp;Dariusz Dudek MD, PhD ,&nbsp;Roberto Garbo MD ,&nbsp;Farrel Hellig MD, PhD ,&nbsp;Jeffrey Moses MD ,&nbsp;Abdul Mozid MD ,&nbsp;Sunao Nakamura MD, PhD ,&nbsp;Billal Patel MD ,&nbsp;Gabor G. Toth MD, PhD ,&nbsp;Nattawut Wongpraparut MD ,&nbsp;Nieves Gonzalo MD, PhD ,&nbsp;Javier Escaned MD, PhD","doi":"10.1016/j.jcin.2024.11.043","DOIUrl":"10.1016/j.jcin.2024.11.043","url":null,"abstract":"<div><div>Since its inception, percutaneous coronary intervention (PCI) has relied upon vessel opacification with iodinated contrast to plan, guide, and assess the results of the procedure. Yet revisiting this fundamental concept is important in contemporary PCI practice, especially in patients with high-risk clinical or anatomical profiles. In addition to decreasing the probability of acute kidney injury during PCI, limiting the volume of iodinated contrast allows the operator to perform more thorough interventions by relying on intracoronary imaging and physiology, ultimately contributing to more complete revascularization and improving the efficacy and durability of the intervention. Ultra-low-contrast PCI (ULCPCI) may thus be useful in performing PCI not only in patients with chronic renal dysfunction but also in those with multivessel coronary artery disease, impaired left ventricular function, and many other scenarios. The aim of this review is to highlight contemporary PCI scenarios in which a ULCPCI approach may be beneficial. The authors provide a structured approach to address the challenges faced by operators in transitioning from conventional contrast-based interventions to ULCPCI, with practical solutions that are accessible to most interventionalists. The reader will learn that ULCPCI is feasible in contemporary practice as a result of technological innovation, the implementation of dedicated skills, and redefining the role of angiography as the cornerstone of contemporary PCI.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 409-424"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
100.73 Mortality and Hospital Length of Stay in Patients with ST-Segment Elevation on EKG
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.019
Eric Taylor, Ester Masati, Ilgizar Khairutdinov, Hayden Braun, Phuong Nhi Le, Safanah Siddiqui, Fernandes Valerian
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引用次数: 0
100.22 Prevention Over Cure: The Role of PKCε in Mitigating Post-Myocardial Infarction Heart Failure
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.037
Desmond Boakye Tanoh , Arjun Nair , Lindon Young
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引用次数: 0
100.46 Comparison of Clinical Outcomes Between Second Generation Drug-Eluting Stents in Acute Myocardial Infarction Patients: 10-Year Follow-Up Results
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.026
Seung-Woon Rha , Se Yeon Choi , Jinah Cha , Byoung Geol Choi , Woo Jin Ahn , Wonsang Chu , Soohyung Park , Ji Young Park , Cheol Ung Choi , Chang Gyu Park
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引用次数: 0
100.31 Geographic Disparities in Managing Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA)
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.023
Zainab Atiyah Dakhil , Hasan Ali Farhan , Julia Grapsa , Mirvat Alasnag
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引用次数: 0
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JACC. Cardiovascular interventions
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