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JACC. Cardiovascular interventions最新文献

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200.03 Blood Pressure Reductions After Radiofrequency Renal Denervation by Patient Age Based on Medicare Eligibility: SPYRAL HTN-OFF and -ON MED 24-Month Results
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.121
Felix Mahfoud , Raymond R. Townsend , David E. Kandzari , Kazuomi Kario , Michael A. Weber , Roland E. Schmieder , Konstantinos Tsioufis , Minglei Liu , Michael Böhm
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引用次数: 0
100.20 The Impact of Age on Microvascular Function: Insights From the Coronary Microvascular Disease Registry
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.090
Abdullah K. Al Qaraghuli , Kalyan R. Chitturi , Matteo Cellamare , Cheng Zhang , Jason Galo , Beni R. Verma , Waiel Abusnina , Abhishek Chaturvedi , Lior Lupu , Dan Haberman , Itsik Ben-Dor , Lowell Satler , Toby Rogers , Ron Waksman , Hayder Hashim , Brian C. Case
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引用次数: 0
100.74 Assessing the Effect of End-Stage Renal Disease on Mortality and Short-Term Complication Risks Among Patients Undergoing Rotational Atherectomy During Inpatient Percutaneous Coronary Interventions
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.058
Fathima Shehnaz Ayoobkhan , Vivek Mittal , Parampreet Johal , Renuka Verma , Kamleshun Ramphul , Hemamalini Sakthivel
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引用次数: 0
100.53 Applying 3Rs Principles for Large Animal Research: A Case Example From Preclinical Mechanical Thrombectomy Study
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.116
Dongming Hou , Wenqi Liu , Zhao Wang , Wendy Zhang , Allen Fan , Yongfeng Li , Cuifen Li , Faye Gu
{"title":"100.53 Applying 3Rs Principles for Large Animal Research: A Case Example From Preclinical Mechanical Thrombectomy Study","authors":"Dongming Hou , Wenqi Liu , Zhao Wang , Wendy Zhang , Allen Fan , Yongfeng Li , Cuifen Li , Faye Gu","doi":"10.1016/j.jcin.2025.01.116","DOIUrl":"10.1016/j.jcin.2025.01.116","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S34"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
100.79 Does Inclusion of Warfarin Instead of Direct-Acting Oral Anticoagulants to Antiplatelets Reduce Risk of Major/minor Bleeding: Insight From a Network Meta-Analysis of Randomized Trials of Patients Undergoing Coronary Interventions
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.031
Supraja Achuthanandan , Hakob Harutyunyan , Marlon Rivera-Boadla , Nnamdi Chukwuka , Saurav Chatterjee
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引用次数: 0
200.29 Catheter-Based Transvascular RF Neural Ablation for Severe Pancreatic Cancer Pain: First Results From the ELPIS Study
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.129
Robert Schwartz , Askar Sabirov
{"title":"200.29 Catheter-Based Transvascular RF Neural Ablation for Severe Pancreatic Cancer Pain: First Results From the ELPIS Study","authors":"Robert Schwartz , Askar Sabirov","doi":"10.1016/j.jcin.2025.01.129","DOIUrl":"10.1016/j.jcin.2025.01.129","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S38"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
200.10 Blood Pressure Response Following Radiofrequency Renal Denervation in the Largest Real-World US Cohort Including Older Patients 200.10 包括老年患者在内的美国最大真实世界队列中射频肾去神经术后的血压反应
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.123
Jeremy Seth Bock
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引用次数: 0
Microvascular Resistance Reserve and Prognosis After Heart Transplantation
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2024.11.011
Junho Ha MD , Seung Hun Lee MD, PhD , Ki-Hong Choi MD, PhD , Doosup Shin MD , David Hong MD , Darae Kim MD, PhD , Jeong Hoon Yang MD, PhD , Yang Hyun Cho MD, PhD , Kiick Sung MD, PhD , Meesoon Park RN , Jung-Sun Kim MD, PhD , Taek-Kyu Park MD, PhD , Young Bin Song MD, PhD , Joo-Yong Hahn MD, PhD , Seung-Hyuk Choi MD, PhD , Hyeon-Cheol Gwon MD, PhD , Jae K. Oh MD, PhD , Jin-Oh Choi MD, PhD , Joo Myung Lee MD, MPH, PhD

Background

Impaired microcirculatory function after heart transplantation is associated with increased risk for acute cellular rejection. Microvascular resistance reserve (MRR) is a novel index for assessing microcirculatory function, irrespective of epicardial coronary artery stenosis, but it has not been validated in transplanted hearts.

Objectives

The aim of this study was to investigate the prognostic impact of MRR in heart transplantation.

Methods

The present study prospectively enrolled 154 heart transplant recipients who underwent scheduled coronary angiography and invasive coronary physiological assessment 1 month after transplantation. Coronary microcirculatory dysfunction was defined as MRR ≤3.0. Elevated microcirculatory resistance was defined as an index of microcirculatory resistance ≥15. The presence of epicardial coronary stenosis was assessed by fractional flow reserve. The primary outcome was a composite of death or biopsy-proven acute cellular rejection of grade ≥ 2R after transplantation.

Results

Among the total patients, 22.1% (34 of 154) had impaired microcirculatory function (MRR ≤3.0), and 77.9% (122 of 154) had preserved microcirculatory function (MRR >3.0). During median follow-up of 730 days (Q1-Q3: 730-730 days), patients with MRR ≤3.0 showed increased risk for a composite of death or acute cellular rejection (adjusted HR: 5.31; 95% CI: 2.65-10.64; P < 0.001), acute cellular rejection (adjusted HR: 4.83; 95% CI: 2.20-10.60; P < 0.001), and death (adjusted HR: 5.19; 95% CI: 1.24-21.62; P = 0.024). MRR was significantly associated with increased risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis (HR adjusted for fractional flow reserve: 1.89 per 1-U decrease in MRR; 95% CI: 1.46-2.46; P < 0.001) or elevated microcirculatory resistance (HR adjusted for index of microcirculatory resistance: 1.90 per 1-U decrease in MRR; 95% CI: 1.43-2.52; P < 0.001).

Conclusions

Impaired microcirculatory function, determined by MRR early after heart transplantation, identified patients at high risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis or elevated microcirculatory resistance. (Physiologic Assessment of Microvascular Function in Heart Transplant Patients; NCT02798731)
{"title":"Microvascular Resistance Reserve and Prognosis After Heart Transplantation","authors":"Junho Ha MD ,&nbsp;Seung Hun Lee MD, PhD ,&nbsp;Ki-Hong Choi MD, PhD ,&nbsp;Doosup Shin MD ,&nbsp;David Hong MD ,&nbsp;Darae Kim MD, PhD ,&nbsp;Jeong Hoon Yang MD, PhD ,&nbsp;Yang Hyun Cho MD, PhD ,&nbsp;Kiick Sung MD, PhD ,&nbsp;Meesoon Park RN ,&nbsp;Jung-Sun Kim MD, PhD ,&nbsp;Taek-Kyu Park MD, PhD ,&nbsp;Young Bin Song MD, PhD ,&nbsp;Joo-Yong Hahn MD, PhD ,&nbsp;Seung-Hyuk Choi MD, PhD ,&nbsp;Hyeon-Cheol Gwon MD, PhD ,&nbsp;Jae K. Oh MD, PhD ,&nbsp;Jin-Oh Choi MD, PhD ,&nbsp;Joo Myung Lee MD, MPH, PhD","doi":"10.1016/j.jcin.2024.11.011","DOIUrl":"10.1016/j.jcin.2024.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Impaired microcirculatory function after heart transplantation is associated with increased risk for acute cellular rejection. Microvascular resistance reserve (MRR) is a novel index for assessing microcirculatory function, irrespective of epicardial coronary artery stenosis, but it has not been validated in transplanted hearts.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the prognostic impact of MRR in heart transplantation.</div></div><div><h3>Methods</h3><div>The present study prospectively enrolled 154 heart transplant recipients who underwent scheduled coronary angiography and invasive coronary physiological assessment 1 month after transplantation. Coronary microcirculatory dysfunction was defined as MRR ≤3.0. Elevated microcirculatory resistance was defined as an index of microcirculatory resistance ≥15. The presence of epicardial coronary stenosis was assessed by fractional flow reserve. The primary outcome was a composite of death or biopsy-proven acute cellular rejection of grade ≥ 2R after transplantation.</div></div><div><h3>Results</h3><div>Among the total patients, 22.1% (34 of 154) had impaired microcirculatory function (MRR ≤3.0), and 77.9% (122 of 154) had preserved microcirculatory function (MRR &gt;3.0). During median follow-up of 730 days (Q1-Q3: 730-730 days), patients with MRR ≤3.0 showed increased risk for a composite of death or acute cellular rejection (adjusted HR: 5.31; 95% CI: 2.65-10.64; <em>P</em> &lt; 0.001), acute cellular rejection (adjusted HR: 4.83; 95% CI: 2.20-10.60; <em>P</em> &lt; 0.001), and death (adjusted HR: 5.19; 95% CI: 1.24-21.62; <em>P</em> = 0.024). MRR was significantly associated with increased risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis (HR adjusted for fractional flow reserve: 1.89 per 1-U decrease in MRR; 95% CI: 1.46-2.46; <em>P</em> &lt; 0.001) or elevated microcirculatory resistance (HR adjusted for index of microcirculatory resistance: 1.90 per 1-U decrease in MRR; 95% CI: 1.43-2.52; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Impaired microcirculatory function, determined by MRR early after heart transplantation, identified patients at high risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis or elevated microcirculatory resistance. (Physiologic Assessment of Microvascular Function in Heart Transplant Patients; <span><span>NCT02798731</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 439-452"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
100.18 12-Month DAPT(PIONEER III) Vs. 1-Month Dapt (PIONEER IV): Comparative Observational Assessment of Bleeding and Ischemic Events After Aspirin Cessation in Patients Treated With Healing-Targeted Supreme Sirolimus-Eluting Stent (HT Supreme)
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.104
Tsung-Ying Tsai , Yoshinobu Onuma , Joanna Wykrzykowska , Faisal Sharif , Liesbeth Rosseel , Mohammad Alkhalil , Edouard Benit , Nick Curzen , Vincent Floré , Kenneth De Wilder , Valeria Paradies , Giovanni Amoroso , Sjoerd Hofma , Samer Somi , Adel Aminia , Clemens von Birgelen , Manel Sabate , Victor Jimenez Diaz , Ignacio Amat Santos , Jeroen Sonck , Patrick W. Serruys
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引用次数: 0
100.11 ABSTRACT WITHDRAWN
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-24 DOI: 10.1016/j.jcin.2025.01.039
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引用次数: 0
期刊
JACC. Cardiovascular interventions
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