Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.081
Seung-Woon Rha , Byoung Geol Choi , Se Yeon Choi , Jinah Cha , Woo Jin Ahn , Wonsang Chu , Soohyung Park , Ji Young Park , Cheol Ung Choi , Chang Gyu Park
{"title":"100.33 Comparison of Clinical Outcomes Between First- and Second-Generation Drug-Eluting Stents in Multi-Vessel Disease Patients: 10-Year Follow-Up Results","authors":"Seung-Woon Rha , Byoung Geol Choi , Se Yeon Choi , Jinah Cha , Woo Jin Ahn , Wonsang Chu , Soohyung Park , Ji Young Park , Cheol Ung Choi , Chang Gyu Park","doi":"10.1016/j.jcin.2025.01.081","DOIUrl":"10.1016/j.jcin.2025.01.081","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages S23-S24"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.113
Beni Rai Verma , Abhinav Sood , Abhishek Chaturvedi , Abdullah K. Al Qaraghuli , Cheng Zhang , Sevket Ozturk , Vaishnavi Sawant , Jason Galo , Dan Haberman , Itsik Ben-Dor , Hayder Hashim , Ron Waksman
{"title":"100.45 Clinical Outcomes Among Patients With Prior Coronary Artery Bypass Graft Surgery Undergoing Percutaneous Coronary Intervention of Native Vessel Versus Saphenous Vein Graft During Non-ST Elevation Myocardial Infarction","authors":"Beni Rai Verma , Abhinav Sood , Abhishek Chaturvedi , Abdullah K. Al Qaraghuli , Cheng Zhang , Sevket Ozturk , Vaishnavi Sawant , Jason Galo , Dan Haberman , Itsik Ben-Dor , Hayder Hashim , Ron Waksman","doi":"10.1016/j.jcin.2025.01.113","DOIUrl":"10.1016/j.jcin.2025.01.113","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S33"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.127
Kevin Kang , Gurjaipal S. Kang , Robert L. Maholic , Silvia Kang , John S. Wilson
{"title":"200.11 Transfemoral Carotid Artery Stenting Has Very Low Stroke, Death, and TIA Rates in Septuagenarians and Octogenarians in Hands of Experienced Interventional Cardiologists","authors":"Kevin Kang , Gurjaipal S. Kang , Robert L. Maholic , Silvia Kang , John S. Wilson","doi":"10.1016/j.jcin.2025.01.127","DOIUrl":"10.1016/j.jcin.2025.01.127","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S38"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Low-gradient (LG) aortic stenosis (AS) has not been fully characterized compared with high-gradient (HG) AS in terms of cardiac damage, frailty, aortic valve calcification, and clinical outcomes.
Objectives
The aim of this study was to compare the clinical characteristics and outcomes between each hemodynamic type of LG AS and HG AS.
Methods
The current study included 3,363 patients in the CURRENT AS (Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis) Registry-2 after excluding patients without indexed stroke volume or left ventricular ejection fraction (LVEF) data. Patients were divided into 4 groups (LG AS with reduced LVEF: n = 285; paradoxical low flow, low gradient [LFLG]: n = 220; normal flow, low gradient [NFLG]: n = 872; HG: n = 1,986).
Results
Compared with HG AS, LG AS with reduced LVEF more often had cardiovascular comorbidities, advanced cardiac damage, and frailty with less severe valve calcification and paradoxical LFLG AS more often had atrial fibrillation, advanced cardiac damage, and frailty with less severe valve calcification, while NFLG AS had comparable cardiac damage and frailty with less severe valve calcification. Cumulative 3-year incidence of death or heart failure hospitalization was higher in LG AS with reduced LVEF and paradoxical LFLG than in HG AS. After adjusting for confounders, LG AS with reduced LVEF and paradoxical LFLG compared with HG AS were independently associated with higher risk for death or heart failure hospitalization (HR: 1.82; 95% CI: 1.49-2.23; P < 0.001; and HR: 1.43; 95% CI: 1.13-1.82; P = 0.003, respectively) but NFLG AS was not (HR: 1.03; 95% CI: 0.88-1.21; P = 0.68).
Conclusions
Clinical outcomes were significantly worse in LG AS with reduced LVEF and paradoxical LFLG AS and comparable in NFLG AS compared with HG AS.
{"title":"Low-Gradient Severe Aortic Stenosis","authors":"Tomohiko Taniguchi MD , Takeshi Morimoto MD, MPH , Yasuaki Takeji MD , Shinichi Shirai MD , Kenji Ando MD , Hiroyuki Tabata MD , Ko Yamamoto MD , Ryosuke Murai MD , Kohei Osakada MD , Hiroki Sakamoto MD , Tomohisa Tada MD , Koichiro Murata MD , Yuki Obayashi MD , Masashi Amano MD , Takeshi Kitai MD , Chisato Izumi MD , Mamoru Toyofuku MD , Norio Kanamori MD , Makoto Miyake MD , Hiroyuki Nakayama MD , Kouji Ueyama","doi":"10.1016/j.jcin.2024.09.044","DOIUrl":"10.1016/j.jcin.2024.09.044","url":null,"abstract":"<div><h3>Background</h3><div>Low-gradient (LG) aortic stenosis (AS) has not been fully characterized compared with high-gradient (HG) AS in terms of cardiac damage, frailty, aortic valve calcification, and clinical outcomes.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare the clinical characteristics and outcomes between each hemodynamic type of LG AS and HG AS.</div></div><div><h3>Methods</h3><div>The current study included 3,363 patients in the CURRENT AS (Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis) Registry-2 after excluding patients without indexed stroke volume or left ventricular ejection fraction (LVEF) data. Patients were divided into 4 groups (LG AS with reduced LVEF: n = 285; paradoxical low flow, low gradient [LFLG]: n = 220; normal flow, low gradient [NFLG]: n = 872; HG: n = 1,986).</div></div><div><h3>Results</h3><div>Compared with HG AS, LG AS with reduced LVEF more often had cardiovascular comorbidities, advanced cardiac damage, and frailty with less severe valve calcification and paradoxical LFLG AS more often had atrial fibrillation, advanced cardiac damage, and frailty with less severe valve calcification, while NFLG AS had comparable cardiac damage and frailty with less severe valve calcification. Cumulative 3-year incidence of death or heart failure hospitalization was higher in LG AS with reduced LVEF and paradoxical LFLG than in HG AS. After adjusting for confounders, LG AS with reduced LVEF and paradoxical LFLG compared with HG AS were independently associated with higher risk for death or heart failure hospitalization (HR: 1.82; 95% CI: 1.49-2.23; <em>P <</em> 0.001; and HR: 1.43; 95% CI: 1.13-1.82; <em>P =</em> 0.003, respectively) but NFLG AS was not (HR: 1.03; 95% CI: 0.88-1.21; <em>P =</em> 0.68).</div></div><div><h3>Conclusions</h3><div>Clinical outcomes were significantly worse in LG AS with reduced LVEF and paradoxical LFLG AS and comparable in NFLG AS compared with HG AS.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 471-487"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.jcin.2025.01.124
Chang Wook Jeong , Jay Budrewicz , John H. Keating , Misty Williams-Fritze , Peter Markham , Abraham R. Tzafriri
{"title":"200.15 Twenty Four Week Safety and Efficacy of a Novel Extravascular Renal Denervation Device in a Porcine Model at an Elevated Temperature Setting","authors":"Chang Wook Jeong , Jay Budrewicz , John H. Keating , Misty Williams-Fritze , Peter Markham , Abraham R. Tzafriri","doi":"10.1016/j.jcin.2025.01.124","DOIUrl":"10.1016/j.jcin.2025.01.124","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages S36-S37"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}