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Contemporary Practice Patterns and Outcomes of Endovascular Revascularization of Acute Limb Ischemia 急性肢体缺血血管内再通术的当代实践模式和结果
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-28 DOI: 10.1016/j.jcin.2024.09.010

Background

Acute limb ischemia is a vascular emergency associated with high rates of limb loss and mortality. As the use of endovascular techniques increases, estimation of rates and predictors of adverse outcomes remains needed.

Objectives

This study sought to assess contemporary outcomes and predictors of adverse events following endovascular treatment of acute limb ischemia in a nationwide, multicenter registry.

Methods

Patients who had peripheral vascular intervention performed for the indication of acute limb ischemia in National Cardiovascular Data Registry Peripheral Vascular Intervention Registry between 2014 and 2020 were included. The primary outcome was a composite of all-cause mortality and major amputation during index hospitalization. Multivariable logistic regression was employed to identify predictors of the composite outcome.

Results

There were 3,541 endovascular procedures performed during the study period. Of these, 132 (3.7%) resulted in death, and 77 (2.2%) resulted in amputation during hospitalization. Thrombolysis catheters were used in 27.7% (n = 981) and thrombectomy catheters in 3.9% (n = 138). Independent predictors of death or amputation included severe lung disease (OR: 1.72; 95% CI: 1.17-2.52), Rutherford Class IIb (OR: 2.44; 95% CI: 1.62-3.65), and end-stage renal disease (OR: 3.94; 95% CI: 0.73-0.85), and preprocedure hemoglobin (OR: 0.78; 95% CI: 0.73- 0.85). Complications included bleeding within 72 hours of intervention (6.7%) and thrombosis (2.8%).

Conclusions

Patients with pre-existing medical comorbidities and those with diminished limb viability were more likely to suffer adverse outcomes. Adverse event rates remain high for patients affected by acute limb ischemia despite its declining incidence.
背景急性肢体缺血是一种血管急症,肢体缺失率和死亡率都很高。方法纳入2014年至2020年间在国家心血管数据注册中心外周血管介入注册中心接受外周血管介入治疗的急性肢体缺血患者。主要结果是指数住院期间全因死亡率和重大截肢的复合结果。研究采用多变量逻辑回归来确定综合结果的预测因素。其中,132例(3.7%)导致死亡,77例(2.2%)导致住院期间截肢。27.7%(981 人)使用了溶栓导管,3.9%(138 人)使用了血栓切除导管。死亡或截肢的独立预测因素包括严重肺病(OR:1.72;95% CI:1.17-2.52)、卢瑟福IIb级(OR:2.44;95% CI:1.62-3.65)和终末期肾病(OR:3.94;95% CI:0.73-0.85),以及术前血红蛋白(OR:0.78;95% CI:0.73-0.85)。并发症包括介入治疗后 72 小时内的出血(6.7%)和血栓形成(2.8%)。尽管急性肢体缺血的发生率在下降,但患者的不良事件发生率仍然很高。
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引用次数: 0
The Double Bioadaptors Culotte (ADAPT-CULOTTE) Technique: From Bench Testing to the First-in-Human Longitudinal Imaging Analysis. 双生物适配器库洛特(ADAPT-CULOTTE)技术:从工作台测试到首次人体纵向成像分析。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-19 DOI: 10.1016/j.jcin.2024.09.059
Siu-Fung Wong, Hiu-Cheong Chow, Karl Chan, Tak-Shun Chung
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引用次数: 0
IVUS-Guided vs Angiography-Guided PCI in Patients With Diabetes With Acute Coronary Syndromes: The IVUS-ACS Trial. 急性冠状动脉综合征糖尿病患者的 IVUS 引导与血管造影引导 PCI:IVUS-ACS试验。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-19 DOI: 10.1016/j.jcin.2024.09.061
Xiaofei Gao, Jing Kan, Zhiming Wu, Mohammad Anjun, Xiang Chen, Jing Chen, Imad Sheiban, Gary S Mintz, Jun-Jie Zhang, Gregg W Stone, Shao-Liang Chen

Background: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) reduces the risk for clinical events in patients with acute coronary syndromes (ACS), compared with angiographic guidance. However, the benefits of IVUS guidance in high-risk patients with diabetes with ACS is uncertain.

Objectives: The aim of this prespecified stratified subgroup analysis from the IVUS-ACS randomized trial was to determine the effectiveness of IVUS-guided PCI vs angiography-guided PCI in patients with diabetes with ACS.

Methods: From August 20, 2019, to October 27, 2022, 1,105 patients with diabetes with ACS were randomized, including 554 patients in the IVUS-guided group and 551 in the angiography-guided group. The primary endpoint was the rate of target vessel failure (TVF) at 1 year, defined as the composite of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization.

Results: At 1-year follow-up, TVF occurred in 20 patients in the IVUS guidance group and in 46 patients in the angiographic guidance group (Kaplan-Meier rates 3.6% vs 8.3%; HR: 0.46; 95% CI: 0.27-0.81; P = 0.007), driven by a reduction in clinically driven target vessel revascularization (0.9% vs 3.8%; P = 0.003). IVUS-guided PCI also reduced the risk for TVF without procedural myocardial infarction (2.0% vs 6.7%; HR: 0.29; 95% CI: 0.15-0.57; P < 0.001) and all-cause mortality (HR: 0.30; 95% CI: 0.10-0.93; P = 0.037). There were no significant differences in the rates of stent thrombosis or major bleeding between the groups.

Conclusions: In the large-scale IVUS-ACS trial, IVUS-guided PCI improved 1-year clinical outcomes in high-risk patients with diabetes with ACS. (1-Month vs 12-Month DAPT for ACS Patients Who Underwent PCI Stratified by IVUS: IVUS-ACS and ULTIMATE-DAPT Trials; NCT03971500).

背景:与血管造影引导相比,血管内超声(IVUS)引导的经皮冠状动脉介入治疗(PCI)可降低急性冠状动脉综合征(ACS)患者发生临床事件的风险。然而,IVUS引导对ACS高危糖尿病患者的益处尚不确定:这项IVUS-ACS随机试验的预设分层亚组分析旨在确定IVUS引导的PCI与血管造影引导的PCI在ACS糖尿病患者中的有效性:2019年8月20日至2022年10月27日,1105名ACS糖尿病患者接受了随机试验,其中IVUS引导组554人,血管造影引导组551人。主要终点是1年后靶血管失败率(TVF),即心源性死亡、靶血管心肌梗死或临床驱动的靶血管血运重建的综合结果:随访 1 年时,IVUS 引导组有 20 名患者发生 TVF,血管造影引导组有 46 名患者发生 TVF(Kaplan-Meier 率:3.6% vs 8.3%;HR:0.46;95% CI:0.27-0.81;P = 0.007),原因是临床驱动的靶血管再通率降低(0.9% vs 3.8%;P = 0.003)。IVUS引导的PCI还降低了无程序性心肌梗死的TVF风险(2.0% vs 6.7%;HR:0.29;95% CI:0.15-0.57;P <0.001)和全因死亡率(HR:0.30;95% CI:0.10-0.93;P = 0.037)。两组间的支架血栓形成率或大出血率无明显差异:结论:在大规模IVUS-ACS试验中,IVUS引导的PCI改善了ACS高危糖尿病患者的1年临床预后。(接受 IVUS 分层 PCI 的 ACS 患者 1 个月与 12 个月 DAPT:IVUS-ACS 和 ULTIMATE-DAPT 试验;NCT03971500)。
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引用次数: 0
Coronary Physiological Indices to Evaluate Myocardial Ischemia in Patients with Aortic Stenosis Undergoing Valve Replacement. 评估接受瓣膜置换术的主动脉瓣狭窄患者心肌缺血的冠状动脉生理指标
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-18 DOI: 10.1016/j.jcin.2024.10.024
Lennert Minten, Keir McCutcheon, Maarten Vanhaverbeke, Laurine Wouters, Stéphanie Bézy, Pierluigi Lesizza, Sander Jentjens, Pascal Frederiks, Tijs Bringmans, Jens-Uwe Voigt, Tom Adriaenssens, Walter Desmet, Peter Sinnaeve, Steven Jacobs, Peter Verbrugghe, Bart Meuris, Stefan Janssens, William F Fearon, Johan Bennett, Christophe Dubois

Background: Evaluation of myocardial ischemia in patients with aortic valve stenosis (AS) with concomitant coronary artery disease (CAD) and possible microvascular dysfunction (MVD) is challenging because fractional flow reserve (FFR) and resting full-cycle ratio (RFR) have not been validated in this clinical setting.

Objectives: The objectives of this study in patients with AS and CAD are: 1. to describe the relationship between hyperemic and resting indices. 2. to investigate the acute and long-term effects of aortic valve replacement (AVR) on epicardial indices and microvascular function. 3. To assess the impact of these changes on clinical decision making. 4. To determine FFR/RFR ischemia cut-off points in AS.

Methods: In this prospective multicentric study, we performed serial measurements of FFR, RFR, and evaluated MVD by means of coronary flow reserve (CFR), the index of microvascular resistance (IMR) and microvascular resistance reserve (MRR) in patients with severe AS and intermediate-to-severe CAD, before and six months after AVR. Patients underwent myocardial perfusion single-photon emission computed tomography (SPECT) before AVR.

Results: In total, 146 coronary lesions in 116 patients were included. Before AVR, we observed high FFR/RFR discordance according to standard cut-off values: FFR-negative (>0.80)/RFR-positive (≤0.89) in 42.3% (68/137) of these lesions. Acutely after AVR, FFR decreased significantly (-0.0120 ± 0.0192, p=0.0045) while RFR remained stable (0.0140 ± 0.0673, p=0.3089). Six months after AVR, FFR decreased (-0.0279±0.0368) while RFR increased significantly (+0.0410±0.0487) (p<0.0001 for both), resulting in 21.5% (21/98) and 39.8% (39/98) of lesions crossing traditional FFR and RFR cut-off lines, respectively. LV-mass decreased significantly (153.68g ± 44.22 before vs 134.66g ± 37.26 after, p<0.0001). MVD was frequently observed at baseline (32.1% abnormal IMR; 68.6% abnormal MRR) with all microvascular parameters improving after AVR. Most accurate cut-offs to predict ischemia were FFR ≤0.83 and RFR ≤0.85 with comparable accuracy (75-80%).

Conclusions: In patients with severe AS and CAD, FFR ≤0.83 and RFR ≤0.85 appear to predict myocardial ischemia more accurately. Six months after AVR, FFR decreases while RFR increases significantly, with simultaneous decrease of LV mass and improvement of microvascular function.

背景:评估伴有冠状动脉疾病(CAD)和可能的微血管功能障碍(MVD)的主动脉瓣狭窄(AS)患者的心肌缺血具有挑战性,因为分数血流储备(FFR)和静息全周期比值(RFR)尚未在这种临床环境中得到验证:这项针对强直性脊柱炎和冠状动脉粥样硬化患者的研究旨在1. 描述充血指数和静息指数之间的关系。2. 研究主动脉瓣置换术(AVR)对心外膜指数和微血管功能的急性和长期影响。3.评估这些变化对临床决策的影响。4.确定 FFR/RFR 在 AS 中的缺血临界点:在这项前瞻性多中心研究中,我们对重度强直性脊柱炎和中重度 CAD 患者进行了 FFR 和 RFR 序列测量,并通过冠状动脉血流储备(CFR)、微血管阻力指数(IMR)和微血管阻力储备(MRR)对 MVD 进行了评估。患者在进行动静脉瓣膜置换术前接受了心肌灌注单光子发射计算机断层扫描(SPECT):结果:共纳入 116 名患者的 146 个冠状动脉病变。在进行 AVR 之前,根据标准截断值,我们观察到 FFR/RFR 高度不一致:其中 42.3%(68/137)的病变为 FFR 阴性(>0.80)/RFR 阳性(≤0.89)。急性 AVR 后,FFR 显著下降(-0.0120 ± 0.0192,p=0.0045),而 RFR 保持稳定(0.0140 ± 0.0673,p=0.3089)。AVR 术后 6 个月,FFR 下降(-0.0279±0.0368),而 RFR 显著增加(+0.0410±0.0487)(p 结论:在重度 AS 和 CAD 患者中,FFR ≤0.83 和 RFR ≤0.85 似乎能更准确地预测心肌缺血。主动脉瓣置换术后六个月,FFR下降,而RFR显著增加,同时左心室质量下降,微血管功能改善。
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引用次数: 0
AI-Assisted PCI: Progress, Hurdles, and Future Pathways? 人工智能辅助 PCI:进展、障碍和未来之路?
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.1016/j.jcin.2024.09.067
Mohamad Alkhouli, Shih-Sheng Chang
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引用次数: 0
Institutional Variation in Patient Radiation Doses During Transcatheter Valve Interventions: A Statewide Experience. 经导管瓣膜介入术中患者辐射剂量的机构差异:全州经验。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.1016/j.jcin.2024.08.048
David A McNamara, Jeremy Albright, Devraj Sukul, Stanley Chetcuti, Annemarie Forrest, Paul Grossman, Raed M Alnajjar, Himanshu Patel, Hitinder S Gurm, Ryan D Madder

Background: Little is known about institutional radiation doses during transcatheter valve interventions.

Objectives: The authors sought to evaluate institutional variability in radiation doses during transcatheter valve interventions.

Methods: Using a large statewide registry, transcatheter edge-to-edge mitral valve repair, transcatheter mitral valve replacement, and transcatheter aortic valve replacement procedures between January 1, 2020, and December 31, 2022, with an air kerma (AK) recorded were analyzed. Patient and procedural characteristics were compared between cases with AK ≥2 and <2 Gy. Associations of variables with AK ≥2 Gy were investigated using Bayesian random effects modeling and median ORs for the performing hospital.

Results: Among 9,446 procedures across 30 hospitals, median (Q1-Q3) procedural AK was 0.592 Gy (0.348-0.989 Gy) with AK ≥2 Gy in 533 cases (5.6%). Wide variation in procedural AK was observed, with an institutional frequency of AK ≥2 Gy ranging from 0.0% to 29.5%. Bayesian modeling identified the performing hospital as more strongly associated with the odds of a procedural AK ≥2 Gy than any patient or procedural factors (hospital median OR: 3.54 [95% credible interval: 2.52-16.66]).

Conclusions: In a large, multicenter state-wide registry, there is wide institutional variability in patient-level radiation doses during transcatheter valve interventions, with the performing hospital having a higher odds of an AK ≥2 Gy than any patient or procedural factors. Future interventions are warranted to reduce procedural-related variation in radiation exposure.

背景:人们对经导管瓣膜介入治疗过程中的机构辐射剂量知之甚少:作者试图评估经导管瓣膜介入治疗过程中机构辐射剂量的可变性:利用全州范围内的大型登记册,对 2020 年 1 月 1 日至 2022 年 12 月 31 日期间记录有空气切迹(AK)的经导管二尖瓣边缘到边缘修补术、经导管二尖瓣置换术和经导管主动脉瓣置换术进行了分析。比较了AK≥2的病例和AK≥2的病例的患者和手术特征:在30家医院的9446例手术中,手术AK的中位数(Q1-Q3)为0.592 Gy(0.348-0.989 Gy),AK≥2 Gy的病例有533例(5.6%)。术中 AK 的差异很大,AK ≥2 Gy 的机构频率从 0.0% 到 29.5% 不等。贝叶斯模型发现,与患者或手术因素相比,手术医院与手术AK≥2 Gy的几率关系更大(医院中位OR:3.54 [95%可信区间:2.52-16.66]):在一个大型、多中心、全州范围的登记中,经导管瓣膜介入治疗过程中患者水平的辐射剂量存在很大的机构差异,与任何患者或手术因素相比,进行手术的医院发生AK≥2 Gy的几率更高。未来有必要采取干预措施,以减少与手术相关的辐射暴露差异。
{"title":"Institutional Variation in Patient Radiation Doses During Transcatheter Valve Interventions: A Statewide Experience.","authors":"David A McNamara, Jeremy Albright, Devraj Sukul, Stanley Chetcuti, Annemarie Forrest, Paul Grossman, Raed M Alnajjar, Himanshu Patel, Hitinder S Gurm, Ryan D Madder","doi":"10.1016/j.jcin.2024.08.048","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.08.048","url":null,"abstract":"<p><strong>Background: </strong>Little is known about institutional radiation doses during transcatheter valve interventions.</p><p><strong>Objectives: </strong>The authors sought to evaluate institutional variability in radiation doses during transcatheter valve interventions.</p><p><strong>Methods: </strong>Using a large statewide registry, transcatheter edge-to-edge mitral valve repair, transcatheter mitral valve replacement, and transcatheter aortic valve replacement procedures between January 1, 2020, and December 31, 2022, with an air kerma (AK) recorded were analyzed. Patient and procedural characteristics were compared between cases with AK ≥2 and <2 Gy. Associations of variables with AK ≥2 Gy were investigated using Bayesian random effects modeling and median ORs for the performing hospital.</p><p><strong>Results: </strong>Among 9,446 procedures across 30 hospitals, median (Q1-Q3) procedural AK was 0.592 Gy (0.348-0.989 Gy) with AK ≥2 Gy in 533 cases (5.6%). Wide variation in procedural AK was observed, with an institutional frequency of AK ≥2 Gy ranging from 0.0% to 29.5%. Bayesian modeling identified the performing hospital as more strongly associated with the odds of a procedural AK ≥2 Gy than any patient or procedural factors (hospital median OR: 3.54 [95% credible interval: 2.52-16.66]).</p><p><strong>Conclusions: </strong>In a large, multicenter state-wide registry, there is wide institutional variability in patient-level radiation doses during transcatheter valve interventions, with the performing hospital having a higher odds of an AK ≥2 Gy than any patient or procedural factors. Future interventions are warranted to reduce procedural-related variation in radiation exposure.</p>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a Septal Occluder to Treat Recurrent Tricuspid Regurgitation After TriClip. 使用房间隔闭塞器治疗 TriClip 术后复发的三尖瓣反流。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-16 DOI: 10.1016/j.jcin.2024.09.057
Thomas Attumalil, Sami Alnasser, Gianluigi Bisleri, Geraldine Ong, Neil P Fam
{"title":"Use of a Septal Occluder to Treat Recurrent Tricuspid Regurgitation After TriClip.","authors":"Thomas Attumalil, Sami Alnasser, Gianluigi Bisleri, Geraldine Ong, Neil P Fam","doi":"10.1016/j.jcin.2024.09.057","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.057","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion. 左心房阑尾闭塞术患者的医生认证与疗效之间的关系
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-16 DOI: 10.1016/j.jcin.2024.10.020
Amit N Vora, Lucy A Pereira, Chengan Du, Zhen Tan, Chien Yu Huang, Daniel J Friedman, Yongfei Wang, Kamil F Faridi, Dhanunjaya R Lakkireddy, Sarah Zimmerman, Angela Y Higgins, Samir R Kapadia, Jeptha P Curtis, James V Freeman

Background: Percutaneous left atrial appendage occlusion (LAAO) is indicated in patients with atrial fibrillation for whom long-term oral anticoagulation is contraindicated. Whether outcomes are different based on operator certification [interventional cardiology (IC) versus electrophysiology (EP)] is unclear.

Objectives: To compare LAAO outcomes by physician certification (EP versus IC) in the NCDR LAAO Registry.

Methods: We identified patients from 2020-2022 undergoing implantation of a Watchman FLX or Amulet LAAO device and stratified patients by primary operator certification. Outcomes of interest included: (1) any major adverse event (MAE), 2) mortality, 3) ischemic stroke, and 4) major bleeding during the initial hospitalization and at 45 days. We performed multivariable Cox proportional hazards regression analysis to determine the risk of adverse events by physician certification.

Results: A total of 1,638 physicians (57% electrophysiologists) performing 91,711 procedures during the study period were included. EPs were more likely to use intracardiac echocardiography (25.2% vs 9.7%, p<0.001) and had lower radiation total (235 mGy vs 305 mGy, p<0.001). EPs were more likely than ICs to discharge patients on DOAC+aspirin, whereas ICs were more likely to discharge patients on single or dual antiplatelet therapy (all p<0.001). In-hospital death (0.1% vs. 0.1%, p=0.46) and MAE (1.5% vs 1.6%, p=0.42) were similar by physician certification. At 45 days, there was no difference in death [HRdeath 1.03, 95% CI (0.89-1.2)] or MAE [HRMAE 0.97, 95% CI (0.91-1.03)] after multivariable regression.

Conclusions: Contemporary LAAO is safe with low rates of procedural complications and no significant differences in procedural outcomes by operator subspecialty after multivariable adjustment. Continued utilization of technology by EPs and ICs is necessary to allow for broad access to this treatment for eligible patients.

背景:经皮左心房阑尾封堵术(LAAO)适用于禁忌长期口服抗凝药的心房颤动患者。介入心脏病学(IC)与电生理学(EP)]操作者认证的结果是否不同尚不清楚:比较 NCDR LAAO 注册中不同医师认证(EP 与 IC)的 LAAO 结果:我们确定了 2020-2022 年期间接受 Watchman FLX 或 Amulet LAAO 装置植入的患者,并根据主要操作者认证对患者进行了分层。相关结果包括(1) 任何重大不良事件 (MAE);2) 死亡率;3) 缺血性中风;4) 首次住院期间和 45 天内的大出血。我们进行了多变量考克斯比例危险回归分析,以确定不同医生认证的不良事件风险:在研究期间,共有 1638 名医生(57% 为电生理学家)实施了 91,711 例手术。多变量回归后,电生理学家更有可能使用心内超声心动图(25.2% vs 9.7%,pdeath 1.03,95% CI (0.89-1.2)]或 MAE [HRMAE 0.97,95% CI (0.91-1.03)]:结论:当代 LAAO 是安全的,手术并发症发生率低,经多变量调整后,手术结果与操作者的亚专科无明显差异。为了让符合条件的患者能够广泛接受这种治疗,EP 和 IC 有必要继续利用该技术。
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引用次数: 0
Impact of Pulmonary Hypertension on Outcomes after Transcatheter Tricuspid Valve Edge-to-Edge Repair. 肺动脉高压对经导管三尖瓣边缘到边缘修复术后疗效的影响
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-16 DOI: 10.1016/j.jcin.2024.10.023
Lukas Stolz, Karl-Patrik Kresoja, Jennifer von Stein, Vera Fortmeier, Benedikt Koell, Wolfgang Rottbauer, Mohammad Kassar, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, Andreas Rück, Philipp M Doldi, Julia Novotny, Monika Zdanyte, Marianna Adamo, Flavien Vincent, Philipp Lurz, Ralph-Stephan von Bardeleben, Thomas J Stocker, Ludwig T Weckbach, Mirjam G Wild, Christian Besler, Stephanie Brunner, Stefan Toggweiler, Julia Grapsa, Tiffany Patterson, Holger Thiele, Tobias Kister, Giuseppe Tarantini, Giulia Masiero, Marco De Carlo, Alessandro Sticchi, Mathias H Konstandin, Eric Van Belle, Marco Metra, Tobias Geisler, Rodrigo Estévez-Loureiro, Peter Luedike, Nicole Karam, Francesco Maisano, Philipp Lauten, Fabien Praz, Mirjam Kessler, Daniel Kalbacher, Volker Rudolph, Christos Iliadis, Philipp Lurz, Jörg Hausleiter, Roman Pfister, Stephan Baldus, Muhammed Gerçek, Felix Rudolph, Sebastian Ludwig, Christoph Pauschinger, Leonhard-Moritz Schneider, Dominik Felbel, Carsten Salomon, Harald Lapp, Tania Puscas, Alain Berrebi, Amir Abbas Mahabadi, Florian Schindhelm, Berenice Caneiro-Queija, Julio C Echarte, Jürgen Schreieck, Andreas Goldschmied, Edoardo Pancaldi, Daniela Tomasoni, Natacha Rousse, Samy Aghezzaf, Norbert Frey, Martin Kraus, Dirk Westermann, Sebastian Rosch, Federico Arturi, Andrea Panza, Matteo Mazzola, Cristina Giannini

Background: Data regarding the association of pulmonary hypertension (PH) and outcomes in patients undergoing transcatheter tricuspid valve edge-to-edge repair (T-TEER) are scarce.

Objectives: To 1) investigate the impact of PH on outcomes after T-TEER and 2) to shed further light into the role of pre- and postcapillary PH in patients undergoing T-TEER for relevant tricuspid regurgitation (TR).

Methods: The study included patients from the EuroTR registry (NCT06307262) who underwent T-TEER for relevant TR from 2016 until 2023 with available invasive evaluation of sPAP using right heart catheterization. Study endpoints were procedural TR reduction, improvement in New York Heart Association (NYHA) function class and a combined endpoint of death or heart failure hospitalization (HFH) at two-years.

Results: Among a total of 1230 patients (mean age 78.6 ±7.0 years; 51.4% women) increasing systolic pulmonary artery pressure (sPAP) was independently associated with increasing rates of two-year death or HFH (hazard ratio 1.027, 95% confidence interval 1.003-1.052, p=0.030; median survival follow up 343 (114-645) days). No significant survival differences were observed for patients with pre- vs. postcapillary PH. Sensitivity analysis revealed a sPAP value of 46 mmHg as optimized threshold for prediction of death or HFH. Being observed in 526 patients (42.8%), elevated sPAP > 46 mmHg was associated with more severe heart failure symptoms at baseline and follow-up. Importantly, NYHA functional class and TR severity significantly improved irrespective of PH.

Conclusion: PH is an important outcome predictor in patients undergoing T-TEER for relevant TR. In contrast to previous studies, no significant differences were observed for patients with pre- and postcapillary PH in terms of survival free from HFH.

背景:经导管三尖瓣边缘对边缘修补术(T-TEER)患者肺动脉高压(PH)与预后的相关数据很少:目的:1)研究PH对T-TEER术后预后的影响;2)进一步阐明毛细血管前和毛细血管后PH在接受T-TEER治疗相关三尖瓣反流(TR)患者中的作用:研究纳入了欧洲三尖瓣反流登记处(NCT06307262)的患者,这些患者在2016年至2023年期间因相关三尖瓣反流接受了T-TEER,并通过右心导管检查对sPAP进行了有创评估。研究终点为程序性TR降低、纽约心脏协会(NYHA)功能分级改善以及两年后死亡或心衰住院(HFH)的综合终点:在总共 1230 名患者(平均年龄 78.6 ± 7.0 岁;51.4% 为女性)中,肺动脉收缩压(sPAP)的升高与两年内死亡或心衰住院率的升高密切相关(危险比 1.027,95% 置信区间 1.003-1.052,P=0.030;中位生存随访 343 (114-645) 天)。前毛细血管 PH 患者与后毛细血管 PH 患者的生存期无明显差异。敏感性分析显示,46 mmHg 的 sPAP 值是预测死亡或高频心动过速的最佳阈值。在 526 例患者(42.8%)中观察到,sPAP 升高 > 46 mmHg 与基线和随访时更严重的心衰症状有关。重要的是,无论PH值如何,NYHA功能分级和TR严重程度都有明显改善:PH值是预测接受T-TEER治疗的相关TR患者预后的重要指标。与之前的研究相比,毛细血管前PH和毛细血管后PH患者的无心力衰竭存活率没有明显差异。
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引用次数: 0
Intravascular Imaging in Patients With Diabetes Undergoing Percutaneous Coronary Intervention. 接受经皮冠状动脉介入治疗的糖尿病患者的血管内成像。
IF 11.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-16 DOI: 10.1016/j.jcin.2024.09.068
Joo-Yong Hahn
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引用次数: 0
期刊
JACC. Cardiovascular interventions
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