Pub Date : 2023-09-04DOI: 10.22358/jafs/168793/2023
M. Sarfraz, H. Ullah, R. Iqbal, G. Shaheen, M. A. Albalawi, F. Alatawi, A. Omran, A. Alareefy, N. Abdulsalam, N. Khateeb, M. Alatawi, N. Zidan, A. Ditta
. Testing natural antihyperlipidemic substances is necessary due to the increasing prevalence of diabetes mellitus, which leads to chronic hyperglycaemia and poses a significant threat to public health and well-being worldwide. The present study investigated the anti-diabetic effect of black pepper, turmeric, and ajwa date pulp + seed and their mixtures as hypolipidemic, antioxidant and protective agents on the liver and kidney by examining histological changes in alloxanised diabetic rats. Eleven groups consisting of eighteen males and eighteen females were divided into a normal control (non-diabetic), a positive control (diabetic), positive groups receiving glibenclamide (10 mg kg -1 body weight), black pepper (BP), turmeric (T), ajwa pulp (AP), ajwa seeds (AS) aqueous extracts and their various combinations. The dose of BP aqueous extract was 50 mg kg -1 body weight, while the dose of the other materials was 500 mg kg -1 body weight. The aqueous extracts were administered orally once daily for eight weeks. Our phytochemical screening detected the presence of fla - vonoids, tannins, saponins, steroids, and alkaloids in these extracts. The results pertaining to serum levels of glucose, lipids, glycosylated haemoglobin, and anti-oxidant biomarkers revealed significant improvements after administration of AS, BP + AS, and the mixture of
。检测天然抗高脂血症物质是必要的,因为糖尿病的发病率不断上升,导致慢性高血糖,并对全世界的公众健康和福祉构成重大威胁。本研究通过观察四氧化糖尿病大鼠的组织学变化,探讨了黑胡椒、姜黄和印度枣果肉+种子及其混合物作为降血脂、抗氧化和保护肝脏和肾脏的作用。11组(雄性18只,雌性18只)分为正常对照组(非糖尿病)、阳性对照组(糖尿病)和阳性组(格列本脲(10 mg kg -1体重)、黑胡椒(BP)、姜黄(T)、ajwa果肉(AP)、ajwa种子(AS)水提物及其不同组合)。BP水提物给药剂量为50 mg kg -1体重,其他材料给药剂量为500 mg kg -1体重。水萃取物每天口服一次,持续8周。我们的植物化学筛选检测到这些提取物中存在类黄酮、单宁、皂苷、类固醇和生物碱。有关血清葡萄糖、血脂、糖化血红蛋白和抗氧化生物标志物水平的结果显示,在给予AS、BP + AS和BP + AS的混合物后,有显著改善
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