Pub Date : 2025-11-01Epub Date: 2025-11-06DOI: 10.1016/j.jaim.2025.101219
Ekta Mishra, Shivam Sharma, Kashinath G. Metri
Major depressive disorder is a common mental disorder with a lifetime prevalence of 4.4 % worldwide. Cognitive dysfunction is a consequence of MDD. A 27-year-old female with MDD since 2015 experienced an acute MDD episode with anxiety, extreme sadness, poor memory, and impaired attention in July 2023 after discontinuation of anti-depressants. She was on anti-depressants since 2023, yet symptoms persisted. She enrolled in yoga therapy in January 2024. Yoga therapy consisted of a 60-min yoga session every day of the week for 12 weeks. She was followed up twice, on the 15th and 90th day. The selective and sustained attention, working memory and depressive symptoms were assessed using the Attention Network Test, Colour Stroop test, Corsi Block test, and the Beck Depression Inventory-II, respectively. There was marked improvement in selected and sustained attention and depressive symptoms but no improvement in working memory on the 90th day compared to baseline and 15th day. This case study concludes that yoga therapy as an add-on to the conventional treatment of MDD may enhance cognition and reduce depressive symptoms in patients with MDD who have a poor response to conventional anti-depressant treatment. This case study provides insights into the possible role of yoga in MDD patients who poorly respond to conventional anti-depressant therapy.
{"title":"Effect of yoga therapy as an add-on to conventional medicine in improving cognitive functions and depressive symptoms in major depressive disorder: A case report","authors":"Ekta Mishra, Shivam Sharma, Kashinath G. Metri","doi":"10.1016/j.jaim.2025.101219","DOIUrl":"10.1016/j.jaim.2025.101219","url":null,"abstract":"<div><div>Major depressive disorder is a common mental disorder with a lifetime prevalence of 4.4 % worldwide. Cognitive dysfunction is a consequence of MDD. A 27-year-old female with MDD since 2015 experienced an acute MDD episode with anxiety, extreme sadness, poor memory, and impaired attention in July 2023 after discontinuation of anti-depressants. She was on anti-depressants since 2023, yet symptoms persisted. She enrolled in yoga therapy in January 2024. Yoga therapy consisted of a 60-min yoga session every day of the week for 12 weeks. She was followed up twice, on the 15th and 90th day. The selective and sustained attention, working memory and depressive symptoms were assessed using the Attention Network Test, Colour Stroop test, Corsi Block test, and the Beck Depression Inventory-II, respectively. There was marked improvement in selected and sustained attention and depressive symptoms but no improvement in working memory on the 90th day compared to baseline and 15th day. This case study concludes that yoga therapy as an add-on to the conventional treatment of MDD may enhance cognition and reduce depressive symptoms in patients with MDD who have a poor response to conventional anti-depressant treatment. This case study provides insights into the possible role of yoga in MDD patients who poorly respond to conventional anti-depressant therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101219"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The life you never imagined—lived : Life profile of Prof. Dr. Subhash Ranade","authors":"Ankita Abhijeet Shirkande , Abhijeet Sarjerao Shirkande , Gunvant Yeola","doi":"10.1016/j.jaim.2025.101229","DOIUrl":"10.1016/j.jaim.2025.101229","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101229"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-14DOI: 10.1016/j.jaim.2025.101184
Manisha Chaudhary, Mandip Goyal, Charmi Mehta
Budd-Chiari Syndrome (BCS) is an uncommon liver disorder characterized by obstruction of hepatic venous outflow. BCS is a rare condition affecting one in a million adults. The obstruction may be thrombotic or non-thrombotic anywhere along the venous course from the hepatic venules to the junction of the inferior vena cava to the right atrium. Patient may present with abdominal pain, ascites along with hepatomegaly, jaundice, bleeding in the oesophagus, oedema in the legs, hepatic encephalopathy and liver failure. Treatment for Budd-Chiari syndrome in modern science are dissolving blood clots, improve liver function and treat complication. A 51-year-old female patient presented with complaints of pain in right side of abdomen, loss of appetite, abdominal heaviness, abdominal distension, nausea and swelling at bilateral lower leg for one month. Ultrasonography of the abdomen revealed cirrhosis of the liver, thrombosis of the right, middle, and left hepatic veins, along with features of BCS with gross ascites. She is known case of Budd-Chiari syndrome along with gross ascites. The patient was treated with Deepana (which simulates the digestion) and Pachana (enhancing digestion) Koshthashodhana (mild purgation) followed by Vardhamana pippalirasayana(administration of Pippali in a increasing dose and then tapering the dose) and Shamana chikitsa (pacifying treatment)). Pathya-apathya (wholesome diet and regimen) were advised in line with the management of Jalodara for three months. After three-months treatment there was changes in liver profile (SGPT reduced from 250 to 47, SGOT from 328 to 68, alkaline phosphate 272 to 134mg/dl). The assessment of quality of life using the Chronic Liver Disease Questionnaire (CLDQ) indicated improvement in quality of life. This suggests that Ayurvedic treatment can give symptomatic relief and help to prevent it further complication and also improve the overall quality of life.
{"title":"Ayurvedic management of Budd Chiari Syndrome – A case report","authors":"Manisha Chaudhary, Mandip Goyal, Charmi Mehta","doi":"10.1016/j.jaim.2025.101184","DOIUrl":"10.1016/j.jaim.2025.101184","url":null,"abstract":"<div><div>Budd-Chiari Syndrome (BCS) is an uncommon liver disorder characterized by obstruction of hepatic venous outflow. BCS is a rare condition affecting one in a million adults. The obstruction may be thrombotic or non-thrombotic anywhere along the venous course from the hepatic venules to the junction of the inferior vena cava to the right atrium. Patient may present with abdominal pain, ascites along with hepatomegaly, jaundice, bleeding in the oesophagus, oedema in the legs, hepatic encephalopathy and liver failure. Treatment for Budd-Chiari syndrome in modern science are dissolving blood clots, improve liver function and treat complication. A 51-year-old female patient presented with complaints of pain in right side of abdomen, loss of appetite, abdominal heaviness, abdominal distension, nausea and swelling at bilateral lower leg for one month. Ultrasonography of the abdomen revealed cirrhosis of the liver, thrombosis of the right, middle, and left hepatic veins, along with features of BCS with gross ascites. She is known case of Budd-Chiari syndrome along with gross ascites. The patient was treated with <em>Deepana</em> (which simulates the digestion) and <em>Pachana</em> (enhancing digestion) <em>Koshthashodhana</em> (mild purgation) followed by <em>Vardhamana pippalirasayana(</em>administration of <em>Pippali</em> in a increasing dose and then tapering the dose) and <em>Shamana chikitsa</em> (pacifying treatment)). <em>Pathya-apathya</em> (wholesome diet and regimen) were advised in line with the management of <em>Jalodara</em> for three months. After three-months treatment there was changes in liver profile (SGPT reduced from 250 to 47, SGOT from 328 to 68, alkaline phosphate 272 to 134mg/dl). The assessment of quality of life using the Chronic Liver Disease Questionnaire (CLDQ) indicated improvement in quality of life. This suggests that Ayurvedic treatment can give symptomatic relief and help to prevent it further complication and also improve the overall quality of life.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101184"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-11-04DOI: 10.1016/j.jaim.2025.101222
A.M.H.S. Attanayake , U.M.G.D. De Silva , A. Upadhyay , A.K. Sahu , P.K. Perera
Stroke due to intracerebral hemorrhage is the most destructive subtype often causing disabilities in survivors. Early motor recovery, improving quality of life and improved social participation are the key aspects of stroke rehabilitation. Ayurveda describes stroke as Pakshaghata and categorized it as a Vata dominant disease.
This case reports the effect of Ayurveda and Sri Lankan traditional medicine in post stroke rehabilitation of a 60-year-old male, known case of diabetes and hypertension with recent left sided hemiplegia due to hemorrhage in the basal ganglia and hemorrhage in the lateral ventricle.
Following initial management at a modern facility for three weeks, the patient received Ayurveda and Sri Lankan traditional interventions for three months in addition to conventional treatment. Improvement was monitored using visual analogue scale, improvement in neurological and motor functions, clinical parameters, quality of life with stroke specific quality of life index, and life satisfaction questionnaire.
Significant improvement in motor functions, muscle tone, rigidity and hyperreflexia were observed. Patient's bladder-bowel control and functional abilities also improved leading to better quality of life. Better control of blood pressure and glucose levels was also observed indicating positive outcomes of integration of Ayurveda with conventional therapy in such cases. No adverse effects were observed during the observation period.
This case report suggests that Ayurveda and folklore medicine may play an important role in improving neuromuscular functions, quality of life and speedy rehabilitation of stroke patients.
{"title":"Role of Ayurveda and Sri Lankan traditional medicine in post hemorrhagic stroke rehabilitation - A Case Report","authors":"A.M.H.S. Attanayake , U.M.G.D. De Silva , A. Upadhyay , A.K. Sahu , P.K. Perera","doi":"10.1016/j.jaim.2025.101222","DOIUrl":"10.1016/j.jaim.2025.101222","url":null,"abstract":"<div><div>Stroke due to intracerebral hemorrhage is the most destructive subtype often causing disabilities in survivors. Early motor recovery, improving quality of life and improved social participation are the key aspects of stroke rehabilitation. Ayurveda describes stroke as Pakshaghata and categorized it as a Vata dominant disease.</div><div>This case reports the effect of Ayurveda and Sri Lankan traditional medicine in post stroke rehabilitation of a 60-year-old male, known case of diabetes and hypertension with recent left sided hemiplegia due to hemorrhage in the basal ganglia and hemorrhage in the lateral ventricle.</div><div>Following initial management at a modern facility for three weeks, the patient received Ayurveda and Sri Lankan traditional interventions for three months in addition to conventional treatment. Improvement was monitored using visual analogue scale, improvement in neurological and motor functions, clinical parameters, quality of life with stroke specific quality of life index, and life satisfaction questionnaire.</div><div>Significant improvement in motor functions, muscle tone, rigidity and hyperreflexia were observed. Patient's bladder-bowel control and functional abilities also improved leading to better quality of life. Better control of blood pressure and glucose levels was also observed indicating positive outcomes of integration of Ayurveda with conventional therapy in such cases. No adverse effects were observed during the observation period.</div><div>This case report suggests that Ayurveda and folklore medicine may play an important role in improving neuromuscular functions, quality of life and speedy rehabilitation of stroke patients.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101222"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-11-15DOI: 10.1016/j.jaim.2025.101267
Bharti Gawai, Amol A. Tagalpallewar, Anil T. Pawar, Akshay M. Baheti
Background
Inflammation plays a crucial role in the pathogenesis of various chronic diseases. Alternative therapies, such as homeopathy, have gained attention for their potential in managing inflammatory conditions. Glycyrrhiza glabra, commonly known as licorice, is well-documented for its anti-inflammatory properties in herbal medicine. However, its efficacy in homeopathic formulations remains largely unexplored.
Objective
This study aimed to evaluate the anti-inflammatory potential of different homeopathic potencies of Glycyrrhiza glabra against lipopolysaccharide (LPS)-induced inflammation in rats.
Methods
Male Wistar rats were divided into seven groups: normal control, LPS-induced inflammation control, dexamethasone-treated, Glycyrrhiza glabra homeopathic mother tincture (GHMT)-treated, and groups treated with Glycyrrhiza glabra homeopathic potency (G6CH, G30CH, G200CH). Anti-inflammatory effects of GHMT, G6CH, G30CH, and G200CH were evaluated against LPS-induced inflammation by measuring paw volume, serum pro-inflammatory cytokine levels [tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)], levels of oxidative stress biomarkers (superoxide dismutase, glutathione, and catalase) in paw tissues, and histopathological changes in inflamed paw tissues.
Results
The results demonstrated a significant reduction in paw volume in GHMT and G200CH-treated groups (p<0.0001) as compared to the inflammation control group. Additionally, the levels of serum TNF-α and IL-6 were significantly lowered (p<0.0001), and oxidative stress biomarkers showed significant improvement (p<0.0001) in GHMT and G200CH-treated groups. Histopathological examination further confirmed the reversal of inflammation-induced tissue changes by G. glabra homeopathic formulations, indicating its anti-inflammatory activity.
Conclusion
These findings provide scientific evidence supporting the anti-inflammatory potential of homeopathic formulations of Glycyrrhiza glabra, particularly GHMT and G200CH. The study suggests that these homeopathic potencies could serve as promising alternative anti-inflammatory agents, warranting further research to elucidate the underlying molecular mechanisms.
{"title":"Anti-inflammatory effects of Glycyrrhiza glabra homeopathic formulations in a rat model of lipopolysaccharide-induced inflammation","authors":"Bharti Gawai, Amol A. Tagalpallewar, Anil T. Pawar, Akshay M. Baheti","doi":"10.1016/j.jaim.2025.101267","DOIUrl":"10.1016/j.jaim.2025.101267","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation plays a crucial role in the pathogenesis of various chronic diseases. Alternative therapies, such as homeopathy, have gained attention for their potential in managing inflammatory conditions. <em>Glycyrrhiza glabra</em>, commonly known as licorice, is well-documented for its anti-inflammatory properties in herbal medicine. However, its efficacy in homeopathic formulations remains largely unexplored.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the anti-inflammatory potential of different homeopathic potencies of <em>Glycyrrhiza glabra</em> against lipopolysaccharide (LPS)-induced inflammation in rats.</div></div><div><h3>Methods</h3><div>Male Wistar rats were divided into seven groups: normal control, LPS-induced inflammation control, dexamethasone-treated, <em>Glycyrrhiza glabra</em> homeopathic mother tincture (GHMT)-treated, and groups treated with <em>Glycyrrhiza glabra</em> homeopathic potency (G6CH, G30CH, G200CH). Anti-inflammatory effects of GHMT, G6CH, G30CH, and G200CH were evaluated against LPS-induced inflammation by measuring paw volume, serum pro-inflammatory cytokine levels [tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)], levels of oxidative stress biomarkers (superoxide dismutase, glutathione, and catalase) in paw tissues, and histopathological changes in inflamed paw tissues.</div></div><div><h3>Results</h3><div>The results demonstrated a significant reduction in paw volume in GHMT and G200CH-treated groups (p<0.0001) as compared to the inflammation control group. Additionally, the levels of serum TNF-α and IL-6 were significantly lowered (p<0.0001), and oxidative stress biomarkers showed significant improvement (p<0.0001) in GHMT and G200CH-treated groups. Histopathological examination further confirmed the reversal of inflammation-induced tissue changes by <em>G. glabra</em> homeopathic formulations, indicating its anti-inflammatory activity.</div></div><div><h3>Conclusion</h3><div>These findings provide scientific evidence supporting the anti-inflammatory potential of homeopathic formulations of <em>Glycyrrhiza glabra</em>, particularly GHMT and G200CH. The study suggests that these homeopathic potencies could serve as promising alternative anti-inflammatory agents, warranting further research to elucidate the underlying molecular mechanisms.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101267"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajjikshara is derived from both plant and mineral sources. It is important to note that the API does not specify standards for Sajjikshara obtained from herbal and Mineral sources. Therefore, a comparative physicochemical analysis is essential to determine its composition.
Objectives
This study was designed to compare Sajjikshara prepared from two distinct sources: herbal-mineral, in terms of pharmaceutics and analytical parameters.
Material and methods
Sajjikshara was prepared using the ash of Duaralabha Panchang (the whole plant of Fagonia cretica Linn.) and Sajjimitti (a special type of soil) according to textual references from Rasa Tarangini and Rasajalanidhi. Both herbal and mineral Sajjikshara (Sajjikshara-H and M, respectively) were analysed using various physicochemical parameters, phytochemical parameters, and concentrations of sodium (Na), potassium (K), carbonate, hydroxide, sulfate, and nitrate groups, as well as microbial load, aflatoxin concentration, and heavy metals (arsenic, mercury, and lead). X-ray diffraction (XRD) analysis was conducted to identify the crystals, and Fourier transform Infra-Red (FTIR) spectroscopy was used to determine the functional groups present in both types of Sajjikshara.
Results
The pH of both Sajjikshara types is approximately the same, exhibiting an alkaline nature. Sajjikshara-M has a higher percentage of ash value, acid-insoluble ash, and concentrations of Na, K, and carbonate groups. The absence of heavy metals, microbial load, and aflatoxins in both Sajjikshara indicates careful preparation. FTIR and XRD analyses of both Sajjikshara types reveal the presence of carbonate crystals.
Conclusion
Sajjikshara derived from minerals contains a higher percentage of sodium, carbonates, and is cost-effective.
{"title":"Synthesis and characterization of Sajjikshara derived from two distinct sources: herbal and mineral","authors":"Piyush Krantikumar Gandhi , Rajesh Kundlikrao Ingole , Ganesh Nigade","doi":"10.1016/j.jaim.2025.101264","DOIUrl":"10.1016/j.jaim.2025.101264","url":null,"abstract":"<div><h3>Background</h3><div><em>Sajjikshara</em> is derived from both plant and mineral sources. It is important to note that the API does not specify standards for <em>Sajjikshara</em> obtained from herbal and Mineral sources. Therefore, a comparative physicochemical analysis is essential to determine its composition.</div></div><div><h3>Objectives</h3><div>This study was designed to compare <em>Sajjikshara</em> prepared from two distinct sources: herbal-mineral, in terms of pharmaceutics and analytical parameters.</div></div><div><h3>Material and methods</h3><div><em>Sajjikshara</em> was prepared using the ash of <em>Duaralabha Panchang</em> (the whole plant of <em>Fagonia cretica</em> Linn.) and <em>Sajjimitti</em> (a special type of soil) according to textual references from Rasa Tarangini and Rasajalanidhi. Both herbal and mineral <em>Sajjikshara</em> (<em>Sajjikshara</em>-H and M, respectively) were analysed using various physicochemical parameters, phytochemical parameters, and concentrations of sodium (Na), potassium (K), carbonate, hydroxide, sulfate, and nitrate groups, as well as microbial load, aflatoxin concentration, and heavy metals (arsenic, mercury, and lead). X-ray diffraction (XRD) analysis was conducted to identify the crystals, and Fourier transform Infra-Red (FTIR) spectroscopy was used to determine the functional groups present in both types of <em>Sajjikshara</em>.</div></div><div><h3>Results</h3><div>The pH of both <em>Sajjikshara</em> types is approximately the same, exhibiting an alkaline nature. <em>Sajjikshara</em>-M has a higher percentage of ash value, acid-insoluble ash, and concentrations of Na, K, and carbonate groups. The absence of heavy metals, microbial load, and aflatoxins in both <em>Sajjikshara</em> indicates careful preparation. FTIR and XRD analyses of both <em>Sajjikshara</em> types reveal the presence of carbonate crystals.</div></div><div><h3>Conclusion</h3><div><em>Sajjikshara</em> derived from minerals contains a higher percentage of sodium, carbonates, and is cost-effective.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101264"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic kidney disease (CKD) and coronary artery disease (CAD) are significant global health challenges with high mortality rates. Conventional treatments often yield limited satisfaction, necessitating exploration of integrative therapeutic approaches. Four patients (3 males, 1 female; ages 39–56) with confirmed CKD (eGFR <15 ml/min) and CAD were enrolled. Patients presented with symptoms including breathing difficulties, chest heaviness, and reduced cardiac function, and were unsatisfied with previous conventional treatments. Patients underwent a 15-day intense program combining yoga, acupuncture, hydrotherapy, manipulative therapy, and specialised naturopathic diet. Daily yoga sessions lasted 60–75 minutes and included specific asanas, breathing techniques and relaxation practices. Heart rate variability (HRV) analysis revealed significant improvements across multiple autonomic function markers, observed across all patients. Mean RR intervals increased, with case 3 rising from 582 ms to 675 ms. RMSSD improved from 22.5 ms to 46.9 ms in case 1, indicating enhanced parasympathetic activity. The Stress Index decreased across all cases, most notably in case 3 from 96.4 to 44.8. The LF/HF ratio approached more balanced levels, with case 3 moving from 2.633 to 0.995, suggesting improved autonomic regulation. The integrated yoga and naturopathic intervention demonstrated potential in improving cardiac autonomic functions in CKD and CAD patients. Results suggest these complementary approaches may offer a promising adjunct to conventional medical management by modulating autonomic nervous system activity.
{"title":"Effects of Yoga and naturopathic intervention on cardiac autonomic functions in chronic kidney disease with coronary artery disease – A Case Series","authors":"Deepa Yoganathan , Vimal Vadivel , Vaishali Narayanan , Maheshkumar Kuppusamy , Meenakshi Venkatesan","doi":"10.1016/j.jaim.2025.101261","DOIUrl":"10.1016/j.jaim.2025.101261","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) and coronary artery disease (CAD) are significant global health challenges with high mortality rates. Conventional treatments often yield limited satisfaction, necessitating exploration of integrative therapeutic approaches. Four patients (3 males, 1 female; ages 39–56) with confirmed CKD (eGFR <15 ml/min) and CAD were enrolled. Patients presented with symptoms including breathing difficulties, chest heaviness, and reduced cardiac function, and were unsatisfied with previous conventional treatments. Patients underwent a 15-day intense program combining yoga, acupuncture, hydrotherapy, manipulative therapy, and specialised naturopathic diet. Daily yoga sessions lasted 60–75 minutes and included specific <em>asanas</em>, breathing techniques and relaxation practices. Heart rate variability (HRV) analysis revealed significant improvements across multiple autonomic function markers, observed across all patients. Mean RR intervals increased, with case 3 rising from 582 ms to 675 ms. RMSSD improved from 22.5 ms to 46.9 ms in case 1, indicating enhanced parasympathetic activity. The Stress Index decreased across all cases, most notably in case 3 from 96.4 to 44.8. The LF/HF ratio approached more balanced levels, with case 3 moving from 2.633 to 0.995, suggesting improved autonomic regulation. The integrated yoga and naturopathic intervention demonstrated potential in improving cardiac autonomic functions in CKD and CAD patients. Results suggest these complementary approaches may offer a promising adjunct to conventional medical management by modulating autonomic nervous system activity.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101261"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This case report is the description of dactylitis associated with Psoriatic arthritis (PsA) of a thirty-eight years old male, government employee. He presented with complaints of pain, swelling, stiffness and restriction of movements in fingers of upper limb, especially distal interphalangeal joints (IJP) for 1 month. Skin manifestations like silvery flaky scales, itching over the scalp region and mild pinkish discoloration on mid dorsum of right foot were also present. Diagnosis was made with the aid of CASPAR criteria, history taking and clinical examination. Only temporary relief was obtained from non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) he had taken for 2 weeks as suggested by conventional treatment. In Ayurvedic parlance, PsA resembles conditions like Gambheera Vatrakta, due to involvement of skin and deeper tissues like bones and joints and dactylitis may be considered as Anguli sopha. Internal medications with properties alleviating three doshas (tridoshahara), skin diseases (kushtahara), vitiated rakta dhatu (raktahara), which detoxifies blood (raktaprasadana), anodyne (soolahara), anti-inflammatory (shothahara), rejuvenating (Rasayana) were used. The assessment was done before and after the treatment by using the Psoriasis Area and Severity Index (PASI) score and European Alliance of Associations for Rheumatology's ‘The Psoriatic Arthritis Impact of Disease 12 (EULAR PsAID 12)’ questionnaire score. It was observed that symptoms were almost completely resolved with Ayurvedic management and changes in biochemical parameters were also noted. Prescribed Ayurvedic medications was found to be a good alternative therapy in managing dactylitis associated with PsA.
{"title":"Ayurvedic management of psoriatic arthritis with Dactylitis - A Case Report","authors":"Sinimol Thekkekkootumughath Peethambaran , Sree Deepthi Girija Nalinakshan","doi":"10.1016/j.jaim.2025.101200","DOIUrl":"10.1016/j.jaim.2025.101200","url":null,"abstract":"<div><div>This case report is the description of dactylitis associated with Psoriatic arthritis (PsA) of a thirty-eight years old male, government employee. He presented with complaints of pain, swelling, stiffness and restriction of movements in fingers of upper limb, especially distal interphalangeal joints (IJP) for 1 month. Skin manifestations like silvery flaky scales, itching over the scalp region and mild pinkish discoloration on mid dorsum of right foot were also present. Diagnosis was made with the aid of CASPAR criteria, history taking and clinical examination. Only temporary relief was obtained from non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) he had taken for 2 weeks as suggested by conventional treatment. In Ayurvedic parlance, PsA resembles conditions like <em>Gambheera Vatrakta</em>, due to involvement of skin and deeper tissues like bones and joints and dactylitis may be considered as <em>Anguli sopha</em>. Internal medications with properties alleviating three doshas <em>(tridoshahara</em>)<em>,</em> skin diseases <em>(kushtahara),</em> vitiated <em>rakta dhatu (raktahara)</em>, which detoxifies blood <em>(raktaprasadana),</em> anodyne <em>(soolahara),</em> anti-inflammatory <em>(shothahara),</em> rejuvenating <em>(Rasayana)</em> were used. The assessment was done before and after the treatment by using the Psoriasis Area and Severity Index (PASI) score and European Alliance of Associations for Rheumatology's ‘The Psoriatic Arthritis Impact of Disease 12 (EULAR PsAID 12)’ questionnaire score. It was observed that symptoms were almost completely resolved with Ayurvedic management and changes in biochemical parameters were also noted. Prescribed Ayurvedic medications was found to be a good alternative therapy in managing dactylitis associated with PsA.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101200"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-11-05DOI: 10.1016/j.jaim.2025.101239
Rajesh Kotecha , Deep Narayan Pandey
The rediscovery of Vrikshayurveda principles offers a holistic framework to address contemporary environmental challenges and support sustainability goals. This analysis provides three foundational principles—Resource Utilization and Regeneration, No Harm to Nature, and Resource Conservation—rooted in the Atharva Veda and integrates ancient wisdom with modern ecological science. Through an exploration of Vedic texts and contemporary literature, these principles are shown to align with regenerative agriculture, natural forest regeneration, and biodiversity conservation, offering practical, scalable, and cost-effective solutions. Their applications extend to urban forestry, regenerative agriculture, and ecosystem recovery, demonstrating the potential to enhance soil health, improve carbon sequestration, and facilitate community-based conservation efforts. Furthermore, this approach also highlights how ancient practices, such as water harvesting and agroforestry, can inform modern strategies to achieve global restoration targets, environmental management, urban greening, and human health promotion. Future research should examine how Vrikshayurveda principles, in conjunction with contemporary science, can systematically be integrated into contemporary conservation policies, bridging cultural heritage with scientific advancements to create resilient ecosystems and sustainable societies through nature-based solutions.
{"title":"Rediscovery of Vrikshayurveda: A nature-based vision for sustainability","authors":"Rajesh Kotecha , Deep Narayan Pandey","doi":"10.1016/j.jaim.2025.101239","DOIUrl":"10.1016/j.jaim.2025.101239","url":null,"abstract":"<div><div>The rediscovery of Vrikshayurveda principles offers a holistic framework to address contemporary environmental challenges and support sustainability goals. This analysis provides three foundational principles—Resource Utilization and Regeneration, No Harm to Nature, and Resource Conservation—rooted in the Atharva Veda and integrates ancient wisdom with modern ecological science. Through an exploration of Vedic texts and contemporary literature, these principles are shown to align with regenerative agriculture, natural forest regeneration, and biodiversity conservation, offering practical, scalable, and cost-effective solutions. Their applications extend to urban forestry, regenerative agriculture, and ecosystem recovery, demonstrating the potential to enhance soil health, improve carbon sequestration, and facilitate community-based conservation efforts. Furthermore, this approach also highlights how ancient practices, such as water harvesting and agroforestry, can inform modern strategies to achieve global restoration targets, environmental management, urban greening, and human health promotion. Future research should examine how Vrikshayurveda principles, in conjunction with contemporary science, can systematically be integrated into contemporary conservation policies, bridging cultural heritage with scientific advancements to create resilient ecosystems and sustainable societies through nature-based solutions.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101239"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herbal drugs are often used alongside conventional cancer therapies to mitigate the adverse effects and enhance therapeutic efficacy. Triphala, a traditional herbal formulation used in Ayurveda, is known for its anticancer and CYP2E1 inhibitory properties. Cisplatin, although highly effective in cancer treatment, is known to cause significant hepatotoxicity and nephrotoxicity which are mediated by toxic metabolites formed through CYP2E1 metabolism.
Objective
The objective of this study is to explore the pharmacokinetic drug interactions between Triphala and cisplatin.
Methods
At the outset, the pharmacokinetic interactions between Triphala and cisplatin were confirmed by in-vitro experiments using HepG2 and 786-0 cell lines based on Reactive Oxygen Species (ROS) generation and cell viability assay, and in-vivo study using Sprague Dawley rats based on serum cisplatin concentration. Later, the literature derived phytoconstituents were subjected to in-silico studies to investigate their molecular interactions with the metabolizing enzyme CYP2E1.
Results
In-vitro studies revealed a reduction in ROS generation and enhanced cell viability, indicating that the metabolism of cisplatin is hindered by Triphala, which was attributed to its CYP2E1 inhibitory potential. In-vivo studies showed a marginal increase in cisplatin concentrations in rat serum that received the combination of Triphala and cisplatin, supporting the in-vitro findings. In-silico studies revealed that Triphala constituents, especially gallic acid and 3,5-dihydroxy-4-methoxybenzoic acid, stably bind and potentially inhibit CYP2E1 via key interactions with THR303.
Conclusion
The results suggest that Triphala may interact with cisplatin by inhibiting the CYP2E1 enzyme, potentially affecting the metabolism and toxicity of cisplatin. These findings highlight the need for further research to evaluate the clinical implications of using Triphala alongside cisplatin-based cancer therapies.
{"title":"Exploring the pharmacokinetic interactions between cisplatin and Triphala through in-vitro, in-vivo, and in-silico approaches – A pilot study to bridge modern medicine with Ayurveda","authors":"T.K. Girija Kumari , Kamatchi Sundara Saravanan , Lakshmi M. Sundar , Gouri Nair , G.N.S. Hemasree , Ganesan Rajalekshmi Saraswathy","doi":"10.1016/j.jaim.2025.101253","DOIUrl":"10.1016/j.jaim.2025.101253","url":null,"abstract":"<div><h3>Background</h3><div>Herbal drugs are often used alongside conventional cancer therapies to mitigate the adverse effects and enhance therapeutic efficacy. Triphala, a traditional herbal formulation used in Ayurveda, is known for its anticancer and CYP2E1 inhibitory properties. Cisplatin, although highly effective in cancer treatment, is known to cause significant hepatotoxicity and nephrotoxicity which are mediated by toxic metabolites formed through CYP2E1 metabolism.</div></div><div><h3>Objective</h3><div>The objective of this study is to explore the pharmacokinetic drug interactions between Triphala and cisplatin.</div></div><div><h3>Methods</h3><div>At the outset, the pharmacokinetic interactions between Triphala and cisplatin were confirmed by <em>in-vitro</em> experiments using HepG2 and 786-0 cell lines based on Reactive Oxygen Species (ROS) generation and cell viability assay, and <em>in-vivo</em> study using Sprague Dawley rats based on serum cisplatin concentration. Later, the literature derived phytoconstituents were subjected to <em>in</em><em>-</em><em>silico</em> studies to investigate their molecular interactions with the metabolizing enzyme CYP2E1.</div></div><div><h3>Results</h3><div><em>In-vitro</em> studies revealed a reduction in ROS generation and enhanced cell viability, indicating that the metabolism of cisplatin is hindered by Triphala, which was attributed to its CYP2E1 inhibitory potential. <em>In-vivo</em> studies showed a marginal increase in cisplatin concentrations in rat serum that received the combination of Triphala and cisplatin, supporting the <em>in-vitro</em> findings. <em>In</em><em>-</em><em>silico</em> studies revealed that Triphala constituents, especially gallic acid and 3,5-dihydroxy-4-methoxybenzoic acid, stably bind and potentially inhibit CYP2E1 via key interactions with THR303.</div></div><div><h3>Conclusion</h3><div>The results suggest that Triphala may interact with cisplatin by inhibiting the CYP2E1 enzyme, potentially affecting the metabolism and toxicity of cisplatin. These findings highlight the need for further research to evaluate the clinical implications of using Triphala alongside cisplatin-based cancer therapies.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101253"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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