The rise in problematic smartphone use among university students underscores the potential of yoga, with its evidence-based ability to improve problematic behaviours at their core.
Objective
To determine whether a ten-week yoga intervention can reduce the symptoms of problematic smartphone usage in university students.
Materials & methods
One hundred fifty participants aged between 18 and 23 years were randomly divided into a yoga (n=75) and a control group (n=75) with an allocation ratio of 1:1. The yoga group received yoga intervention for ten-weeks, whereas the control group carried out their normal daily routine. Each participant was assessed for the symptoms of problematic smartphone usage at baseline, post intervention and two months follow-up by using a standardized Problematic Use of Mobile Phone (PUMP) scale.
Results
Data were analyzed using SPSS 24.0. Repeated measure analyses of variance (RM-ANOVA) with baseline PUMP score used as a covariate have shown a significant reduction in overall problematic smartphone usage (p<0.001; Bonferroni adjusted post hoc analyses) in the yoga group after ten-week of yoga intervention and at two months follow-up (p<0.001).
Conclusions
The results suggest that regular practice of yoga may act as a useful approach to reduce the problematic smartphone usage and its associated symptoms in university students.
{"title":"Effect of ten-week yoga intervention on problematic smartphone usage in university students: A randomized controlled trial","authors":"Vatsala Thapliyal, Jairam Kushwaha, Ghanshyam Singh Thakur","doi":"10.1016/j.jaim.2025.101199","DOIUrl":"10.1016/j.jaim.2025.101199","url":null,"abstract":"<div><h3>Background</h3><div>The rise in problematic smartphone use among university students underscores the potential of yoga, with its evidence-based ability to improve problematic behaviours at their core.</div></div><div><h3>Objective</h3><div>To determine whether a ten-week yoga intervention can reduce the symptoms of problematic smartphone usage in university students.</div></div><div><h3>Materials & methods</h3><div>One hundred fifty participants aged between 18 and 23 years were randomly divided into a yoga (n=75) and a control group (n=75) with an allocation ratio of 1:1. The yoga group received yoga intervention for ten-weeks, whereas the control group carried out their normal daily routine. Each participant was assessed for the symptoms of problematic smartphone usage at baseline, post intervention and two months follow-up by using a standardized Problematic Use of Mobile Phone (PUMP) scale.</div></div><div><h3>Results</h3><div>Data were analyzed using SPSS 24.0. Repeated measure analyses of variance (RM-ANOVA) with baseline PUMP score used as a covariate have shown a significant reduction in overall problematic smartphone usage (<em>p</em><0.001; Bonferroni adjusted <em>post hoc</em> analyses) in the yoga group after ten-week of yoga intervention and at two months follow-up (<em>p</em><0.001).</div></div><div><h3>Conclusions</h3><div>The results suggest that regular practice of yoga may act as a useful approach to reduce the problematic smartphone usage and its associated symptoms in university students.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101199"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.jaim.2025.101195
Rohini Dayma , Rudra B. Bhandari , Prakash Chintamani Malshe , Tung Vir Singh Arya
Background
The most common cause of acid-peptic diseases (APDs) is Helicobacter Pylori (H. pylori) infection. Conventionally, proton–pump inhibitors (PPIs) are used to manage hyperacidity and dyspepsia. PPIs’ persistent use can lead to bacterial resistance, side effects, poor quality of life (QoL), and increased economic burden. H. pylori, being microaerophilic, can be inhibited by gut aeration. Therefore, yogic gut aeration techniques (YGATs) may be a potential option to mitigate H. pylori-induced APDs and reduce medication doses and economic burden.
Objective
The study aimed to determine the effect of YGATs on gastrointestinal symptoms, stress, and quality of life (QoL) in patients with H. pylori-induced APDs.
Method
Patients with epigastric pain, gastric reflux, and stomach burning were screened and allowed to undergo an endoscopy followed by a rapid urease test (RUT) to confirm H. pylori infection. Thirty-four patients with positive RUT were randomly assigned into two groups. The yoga group (n = 16) received YGAT for two months and seven days in addition to PPI. The control group (n = 18) was provided only PPIs. Signs and symptoms of APD and its co-morbidities (stress and QoL) were measured by using the gastrointestinal symptom rating scale (GSRS), quality of life in reflux and dyspepsia (QOLRAD) questionnaire, and stress indicator questionnaire (SIQ).
Results
Split-plot ANOVA computed with Bonferroni adjusted post hoc analyses for intra and inter-group comparisons using the 24th version of IBM-SPSS showed a significant reduction in gastrointestinal symptoms (p<0.001) and stress (p<0.001) and improvement in QoL (p<0.001) in the yoga group as compared to the control group.
Conclusion
YGATs may be a harmless and inexpensive alternative or add-on therapy to mitigate H. pylori-induced APDs and their psychological co-morbidities.
{"title":"Yogic gut aeration techniques to inhibit Helicobacter pylori-induced acid peptic diseases: A pilot randomized controlled trial","authors":"Rohini Dayma , Rudra B. Bhandari , Prakash Chintamani Malshe , Tung Vir Singh Arya","doi":"10.1016/j.jaim.2025.101195","DOIUrl":"10.1016/j.jaim.2025.101195","url":null,"abstract":"<div><h3>Background</h3><div>The most common cause of acid-peptic diseases (APDs) is <em>Helicobacter Pylori</em> (<em>H. pylori)</em> infection<em>.</em> Conventionally, proton–pump inhibitors (PPIs) are used to manage hyperacidity and dyspepsia. PPIs’ persistent use can lead to bacterial resistance, side effects, poor quality of life (QoL), and increased economic burden. <em>H. pylori,</em> being microaerophilic, can be inhibited by gut aeration. Therefore, yogic gut aeration techniques (YGATs) may be a potential option to mitigate <em>H. pylori-</em>induced APDs and reduce medication doses and economic burden.</div></div><div><h3>Objective</h3><div>The study aimed to determine the effect of YGATs on gastrointestinal symptoms, stress, and quality of life (QoL) in patients with <em>H. pylori-</em>induced APDs.</div></div><div><h3>Method</h3><div>Patients with epigastric pain, gastric reflux, and stomach burning were screened and allowed to undergo an endoscopy followed by a rapid urease test (RUT) to confirm <em>H. pylori</em> infection. Thirty-four patients with positive RUT were randomly assigned into two groups. The yoga group (n = 16) received YGAT for two months and seven days in addition to PPI. The control group (n = 18) was provided only PPIs. Signs and symptoms of APD and its co-morbidities (stress and QoL) were measured by using the gastrointestinal symptom rating scale (GSRS), quality of life in reflux and dyspepsia (QOLRAD) questionnaire, and stress indicator questionnaire (SIQ).</div></div><div><h3>Results</h3><div>Split-plot ANOVA computed with Bonferroni adjusted post hoc analyses for intra and inter-group comparisons using the 24th version of IBM-SPSS showed a significant reduction in gastrointestinal symptoms (<em>p<</em>0.001) and stress (<em>p<</em>0.001) and improvement in QoL (<em>p<</em>0.001) in the yoga group as compared to the control group.</div></div><div><h3>Conclusion</h3><div>YGATs may be a harmless and inexpensive alternative or add-on therapy to mitigate <em>H. pylori</em>-induced APDs and their psychological co-morbidities.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101195"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.jaim.2025.101182
Shuvasree Bhattacharya , Pritam Goswami
Knee pain is the most frequently encountered complaint in clinical practice among diverse age groups. In India, osteoarthritis alone covers 25–35 % of all rheumatological conditions. That stands out as one of the common causes of misdiagnosis of all other soft tissue and ligamentous diseases of the knee joint. However, in light of common clinical manifestations like osteoarthritis, many cases go neglected and remains in the grey area of literature. Here we are reporting a case of a 65-year-old female patient who presented with knee pain, and difficulty walking, and she was previously diagnosed with osteoarthritis. However, ultrasonography (USG) revealed a cystic enlargement measuring 12.3 × 5.4mm distal to the medial-cutaneous ligament (MCL) with inflammation and local edema. Following a thorough case evaluation, the patient was prescribed Ruta graveolens 200CH, followed by Thuja occidentalis 200CH. The anti-inflammatory, anti-tumor, and anti-cancer properties of both these medicines have been thoroughly demonstrated via many scientific experiments. We believe the positive effect is due to their alkaloids, but we have not questioned how they maintain their qualities at such high dilutions. The Lysholm Knee Score and Tegner Activity Scale (TLSS) were used to quantify progressive improvement. Significant improvement was observed with the following remission of cystic edema and local irritation. The TLSS climbed to 78 at the end of treatment from 56 at the beginning. Despite being a rare clinical presentation of knee pain, this case report is valuable in homeopathy since it is the first attempt to analyze knee joint functionality using TLSS.
膝关节疼痛是临床实践中不同年龄组中最常见的主诉。在印度，仅骨关节炎就占所有风湿病的25 - 35%。这是所有其他膝关节软组织和韧带疾病误诊的常见原因之一。然而，鉴于骨关节炎等常见的临床表现，许多病例被忽视，停留在文献的灰色地带。这里我们报告一个65岁的女性患者，她表现为膝盖疼痛，行走困难，她之前被诊断为骨关节炎。然而，超声检查（USG）显示，在内侧皮肤韧带（MCL）远端有12.3 × 5.4mm的囊性增大，伴有炎症和局部水肿。经过全面的病例评估后，给患者开了Ruta graveolens 200CH，然后开了huja occidentalis 200CH。这两种药物的抗炎、抗肿瘤和抗癌特性已经通过许多科学实验得到了充分的证明。我们相信这种积极的效果是由于它们的生物碱，但我们没有质疑它们是如何在如此高的稀释度下保持其品质的。采用Lysholm膝关节评分和Tegner活动量表（TLSS）对进行性改善进行量化。随着囊性水肿和局部刺激的缓解，观察到明显的改善。治疗结束时，TLSS由治疗开始时的56分攀升至78分。尽管膝关节疼痛是一种罕见的临床表现，但本病例报告在顺势疗法中是有价值的，因为它是第一次尝试使用TLSS分析膝关节功能。
{"title":"Cystic swelling and inflammation of MCL of knee joint managed with homeopathy; a case study with literature review and diagnostic pitfalls","authors":"Shuvasree Bhattacharya , Pritam Goswami","doi":"10.1016/j.jaim.2025.101182","DOIUrl":"10.1016/j.jaim.2025.101182","url":null,"abstract":"<div><div>Knee pain is the most frequently encountered complaint in clinical practice among diverse age groups. In India, osteoarthritis alone covers 25–35 % of all rheumatological conditions. That stands out as one of the common causes of misdiagnosis of all other soft tissue and ligamentous diseases of the knee joint. However, in light of common clinical manifestations like osteoarthritis, many cases go neglected <em>and remains in the</em> grey area of literature. Here we are reporting a case of a 65-year-old female patient who presented with knee pain, and difficulty walking, and she was previously diagnosed with osteoarthritis. However, ultrasonography (USG) revealed a cystic enlargement measuring 12.3 × 5.4mm distal to the medial-cutaneous ligament (MCL) with inflammation and local edema. Following a thorough case evaluation, the patient was prescribed Ruta graveolens 200CH, followed by Thuja occidentalis 200CH. The anti-inflammatory, anti-tumor, and anti-cancer properties of both these medicines have been thoroughly demonstrated via many scientific experiments. We believe the positive effect is due to their alkaloids, but we have not questioned how they maintain their qualities at such high dilutions. The Lysholm Knee Score and Tegner Activity Scale (TLSS) were used to quantify progressive improvement. Significant improvement was observed with the following remission of cystic edema and local irritation. The TLSS climbed to 78 at the end of treatment from 56 at the beginning. Despite being a rare clinical presentation of knee pain, this case report is valuable in homeopathy since it is the first attempt to analyze knee joint functionality using TLSS.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101182"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.jaim.2025.101174
Rahul Katkar , Aadithyaraj K.T. , Usha Rana
Diabetic foot ulcers (DFUs) occur in 15–25 % of diabetic patients at some point in their lifetime. The wide surgical debridement of the septic area is the cornerstone of diabetic foot ulcer treatment. There is a need to explore alternate therapies for DFU to reduce the risk of severe amputation. A 50-year-old male visited the Ayurveda OPD with a chronic ulcer on the plantar aspect of his right forefoot, which had persisted for two months. Ayurveda has considered Dushta vrana (∼septic nonhealing ulcer) and mentioned the Vrana upkrama (∼wound care measures) for its management. Among these Vrana upkrama, Jalauka avcharana (∼bloodletting using leech), Vrana Shodhana (∼wound cleansing measures) by Parisheka (∼therapeutic streaming of medicated decoction), Vrana ropana (∼wound-healing measures) are the three main wound care approaches along with Shamana (∼palliative therapy) for three months adopted in the present case for managing diabetic foot ulcers. DMIST tool was used to assess wound care at baseline and during follow-up. After three months of treatment, the integrated approach effectively shortens the healing time of DFUs, reduces the amputation rate and improves the standard of living of patients with DFUs with multiple Ayurvedic treatments.
{"title":"Healingwith integrative management of Diabetic foot ulcer - A case report","authors":"Rahul Katkar , Aadithyaraj K.T. , Usha Rana","doi":"10.1016/j.jaim.2025.101174","DOIUrl":"10.1016/j.jaim.2025.101174","url":null,"abstract":"<div><div>Diabetic foot ulcers (DFUs) occur in 15–25 % of diabetic patients at some point in their lifetime. The wide surgical debridement of the septic area is the cornerstone of diabetic foot ulcer treatment. There is a need to explore alternate therapies for DFU to reduce the risk of severe amputation. A 50-year-old male visited the Ayurveda OPD with a chronic ulcer on the plantar aspect of his right forefoot, which had persisted for two months. Ayurveda has considered <em>Dushta vrana</em> (∼septic nonhealing ulcer) and mentioned the <em>Vrana upkrama</em> (∼wound care measures) for its management. Among these <em>Vrana upkrama, Jalauka avcharana</em> (∼bloodletting using leech)<em>, Vrana Shodhana</em> (∼wound cleansing measures) by <em>Parisheka</em> (∼therapeutic streaming of medicated decoction)<em>, Vrana ropana</em> (∼wound-healing measures) are the three main wound care approaches along with <em>Shamana</em> (∼palliative therapy) for three months adopted in the present case for managing diabetic foot ulcers. DMIST tool was used to assess wound care at baseline and during follow-up. After three months of treatment, the integrated approach effectively shortens the healing time of DFUs, reduces the amputation rate and improves the standard of living of patients with DFUs with multiple Ayurvedic treatments.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101174"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.
Objective
To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders
Materials and Methods
A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India. The study included 29 consenting patients(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on changes in anthropometry and biochemical markers was analyzed using paired samples t-test.
Results
A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05). None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.
Conclusion
IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.
{"title":"Safety and potential utility of integrated Yoga and Ayurveda (IYA) intervention for psychotropic-associated metabolic syndrome in patients with severe mental disorders: A prospective single-arm pre-post pilot study","authors":"Chandrasenan Santhosh , Bhargav Hemant , Varambally Shivarama , Chikkanna Umesh , Jasti Nishitha , Suresh Meena Amritha , Ramakrishna Kishore Kumar","doi":"10.1016/j.jaim.2025.101198","DOIUrl":"10.1016/j.jaim.2025.101198","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders</div></div><div><h3>Materials and Methods</h3><div>A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India<em>. The study included 29 consenting patients</em>(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on <strong><em>changes in anthropometry and biochemical markers</em></strong> was analyzed using paired samples <em>t</em>-test.</div></div><div><h3>Results</h3><div><strong><em>A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05).</em></strong> None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.</div></div><div><h3>Conclusion</h3><div>IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101198"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-06DOI: 10.1016/j.jaim.2025.101179
Payal P Wavhal
{"title":"An epistemological framework for advancing the integration of Ayurveda & modern medicine.","authors":"Payal P Wavhal","doi":"10.1016/j.jaim.2025.101179","DOIUrl":"10.1016/j.jaim.2025.101179","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"101179"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a chronic skin disorder with a substantial global burden, affecting over 100 million people worldwide. Conventional treatments, including topical and systemic therapies, have their own limitations and side effects. Siddha medicine, deeply rooted with comprehensive principles, offers an alternative approach in Psoriasis management. This randomized controlled trial aims to explore the safety and efficacy of Sivanarvembu Kuzhithailam, a classical Siddha medicine in the management of Psoriasis.
Objectives
The primary objective of this RCT is to determine the safety and efficacy of Sivanarvembu Kuzhithailam (SVK) and Vetpalai thailam and to reduce the PASI score in Psoriasis patients significantly. The secondary objective involves validating the biochemical changes in the study participants and determining enhancements in their quality of life before and after treatment. As a result, specific inflammatory markers, proteins, antioxidants, and assessments of oxidative stress have been undertaken in this clinical trial to provide deeper insights into the extent of inflammation, disease severity, and the mechanisms of action of the trial drug.
Methods
This is a single center, open-label, parallel group, exploratory randomized controlled trial with a sample size of 90 and with the objective of determining the safety and efficacy of Sivanarvembu Kuzhithailam in the management of psoriasis. This study protocol followed the SPIRIT 2013 guidelines.
Result
The primary outcome is to measure the reduction in the Psoriasis Area and Severity Index (PASI) score from baseline to 91 days and safety parameters. Secondary outcomes include the evaluation of enhancements in participants' quality of life through the assessment of the Dermatology Life Quality Index, as well as the examination of antioxidant levels, inflammatory markers, biochemical markers, in blood samples of trial participants.
Conclusion
The outcome of the study can be extrapolated to the next level of clinical trials with larger populations to provide robust scientific evidence for this traditional Siddha formulation for global acceptance.
{"title":"A randomized controlled study protocol to determine the safety and efficacy of Sivanarvembu Kuzhithailam in the management of Psoriasis (Kalanjagapadai)","authors":"Rathinamala Rathinam , Gayathri Gunalan , Lavanya Alagusolaiyan , Vinu Bharathi Balasubramaniam , Rajendra Kumar Arumugam , Sathiyarajeswaran Parameswaran","doi":"10.1016/j.jaim.2025.101191","DOIUrl":"10.1016/j.jaim.2025.101191","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic skin disorder with a substantial global burden, affecting over 100 million people worldwide. Conventional treatments, including topical and systemic therapies, have their own limitations and side effects. Siddha medicine, deeply rooted with comprehensive principles, offers an alternative approach in Psoriasis management. This randomized controlled trial aims to explore the safety and efficacy of <em>Sivanarvembu Kuzhithailam</em>, a classical Siddha medicine in the management of Psoriasis.</div></div><div><h3>Objectives</h3><div>The primary objective of this RCT is to determine the safety and efficacy of Sivanarvembu Kuzhithailam (SVK) and Vetpalai thailam and to reduce the PASI score in Psoriasis patients significantly. The secondary objective involves validating the biochemical changes in the study participants and determining enhancements in their quality of life before and after treatment. As a result, specific inflammatory markers, proteins, antioxidants, and assessments of oxidative stress have been undertaken in this clinical trial to provide deeper insights into the extent of inflammation, disease severity, and the mechanisms of action of the trial drug.</div></div><div><h3>Methods</h3><div>This is a single center, open-label, parallel group, exploratory randomized controlled trial with a sample size of 90 and with the objective of determining the safety and efficacy of Sivanarvembu Kuzhithailam in the management of psoriasis. This study protocol followed the SPIRIT 2013 guidelines.</div></div><div><h3>Result</h3><div>The primary outcome is to measure the reduction in the Psoriasis Area and Severity Index (PASI) score from baseline to 91 days and safety parameters. Secondary outcomes include the evaluation of enhancements in participants' quality of life through the assessment of the Dermatology Life Quality Index, as well as the examination of antioxidant levels, inflammatory markers, biochemical markers, in blood samples of trial participants.</div></div><div><h3>Conclusion</h3><div>The outcome of the study can be extrapolated to the next level of clinical trials with larger populations to provide robust scientific evidence for this traditional Siddha formulation for global acceptance.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101191"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-30DOI: 10.1016/j.jaim.2025.101172
P.K.V. Anand, Vaishali Deshpande
Hypothyroidism as a sequel to Hashimoto's thyroiditis is a very common thyroid illness. The conventional treatment is replacement of thyroid hormone to compensate insufficient production from the gland. The clinical features manifested is of widely variable intensity and may not be proportionate always to the blood levels of hormones. The disease does not have a direct mention in Ayurvedic classics. In such instances, treatment principle is adopted from the principles of treatment mentioned for those diseases which holds a similarity in etiopathogenesis, based on the clinical presentations and Dosha-Dooshya analysis. Thus, treatment principles of various diseases such as Galagandam, Agnimandyam, Sthoulyam etc., are being used for the treatment of thyroid diseases. A case of hypothyroidism presented with clinical features similar to Pandurogam was managed with the medicines described in the context of Pandurogam and Sopham. Higher TSH levels were brought to normal limits and high anti thyroid peroxidase level was reduced with a set of Ayurvedic medicines for a longer duration. Keeping away from the popular translation of Pandurogam as Anemia, a symptom oriented diagnostic work up based exclusively on the Ayurvedic classics, followed by symptom-oriented selection of medicines suited to the diagnosis is effective in reducing both symptoms and blood values. This gives the hope of managing hypothyroidism with alternate treatment methods other than supplementation of hormone for lifelong.
{"title":"Hashimoto's thyroiditis and hypothyroidism, treated with Shamana Chikitsa principles of Panduroga – A case report","authors":"P.K.V. Anand, Vaishali Deshpande","doi":"10.1016/j.jaim.2025.101172","DOIUrl":"10.1016/j.jaim.2025.101172","url":null,"abstract":"<div><div>Hypothyroidism as a sequel to Hashimoto's thyroiditis is a very common thyroid illness. The conventional treatment is replacement of thyroid hormone to compensate insufficient production from the gland. The clinical features manifested is of widely variable intensity and may not be proportionate always to the blood levels of hormones. The disease does not have a direct mention in Ayurvedic classics. In such instances, treatment principle is adopted from the principles of treatment mentioned for those diseases which holds a similarity in etiopathogenesis, based on the clinical presentations and Dosha-Dooshya analysis. Thus, treatment principles of various diseases such as Galagandam, Agnimandyam, Sthoulyam etc., are being used for the treatment of thyroid diseases. A case of hypothyroidism presented with clinical features similar to Pandurogam was managed with the medicines described in the context of Pandurogam and Sopham. Higher TSH levels were brought to normal limits and high anti thyroid peroxidase level was reduced with a set of Ayurvedic medicines for a longer duration. Keeping away from the popular translation of Pandurogam as Anemia, a symptom oriented diagnostic work up based exclusively on the Ayurvedic classics, followed by symptom-oriented selection of medicines suited to the diagnosis is effective in reducing both symptoms and blood values. This gives the hope of managing hypothyroidism with alternate treatment methods other than supplementation of hormone for lifelong.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101172"},"PeriodicalIF":1.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-30DOI: 10.1016/j.jaim.2025.101201
V. Ashwathykutty , Unnikrishnan Payyappallimana , V. Rakesh Narayanan
Clinical practice guidelines (CPGs), which incorporate current evidence with the pondered judgment of experts, represent a promising approach to reducing unwarranted practice variation and promoting the application of research findings in clinical settings.
Globally, CPGs are developed by numerous local, national, and international organizations, and their production has significantly increased in the last two decades. In the realm of Traditional and Complementary Medicine (T&CM), CPGs are gaining popularity, offering evidence-based recommendations for implementing T&CM interventions in clinical practice.
While Korean medicine, Traditional Chinese medicine, and Kampo medicine have established robust CPGs guiding their healthcare practices and research in selected areas, the utilization of CPGs in any of the Ayush (term that represents the traditional and complementary systems of medicine, namely Ayurveda, Yoga & Naturopathy, Unani, Siddha, Sowa Rigpa and Homoeopathy) systems of medicine remains largely unexplored. This paper advocates for investigating the feasibility of CPGs as a promising research program, outlining areas where they could be implemented and the benefits they could bring. It represents one of the initial studies exploring the potential of CPGs in Ayurveda.
The authors argue that it is crucial for stakeholders to provide the necessary momentum to develop robust and effective CPGs that integrate research with clinical practice to enhance patient care.
{"title":"Addressing clinical practice variability in Ayurveda: An urgent need for developing clinical practice guidelines","authors":"V. Ashwathykutty , Unnikrishnan Payyappallimana , V. Rakesh Narayanan","doi":"10.1016/j.jaim.2025.101201","DOIUrl":"10.1016/j.jaim.2025.101201","url":null,"abstract":"<div><div>Clinical practice guidelines (CPGs), which incorporate current evidence with the pondered judgment of experts, represent a promising approach to reducing unwarranted practice variation and promoting the application of research findings in clinical settings.</div><div>Globally, CPGs are developed by numerous local, national, and international organizations, and their production has significantly increased in the last two decades. In the realm of Traditional and Complementary Medicine (T&CM), CPGs are gaining popularity, offering evidence-based recommendations for implementing T&CM interventions in clinical practice.</div><div>While Korean medicine, Traditional Chinese medicine, and Kampo medicine have established robust CPGs guiding their healthcare practices and research in selected areas, the utilization of CPGs in any of the Ayush (term that represents the traditional and complementary systems of medicine, namely Ayurveda, Yoga & Naturopathy, Unani, Siddha, Sowa Rigpa and Homoeopathy) systems of medicine remains largely unexplored. This paper advocates for investigating the feasibility of CPGs as a promising research program, outlining areas where they could be implemented and the benefits they could bring. It represents one of the initial studies exploring the potential of CPGs in Ayurveda.</div><div>The authors argue that it is crucial for stakeholders to provide the necessary momentum to develop robust and effective CPGs that integrate research with clinical practice to enhance patient care.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101201"},"PeriodicalIF":1.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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