Pub Date : 2025-09-01Epub Date: 2025-08-06DOI: 10.1016/j.jaim.2025.101179
Payal P Wavhal
{"title":"An epistemological framework for advancing the integration of Ayurveda & modern medicine.","authors":"Payal P Wavhal","doi":"10.1016/j.jaim.2025.101179","DOIUrl":"10.1016/j.jaim.2025.101179","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"101179"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.jaim.2025.101174
Rahul Katkar , Aadithyaraj K.T. , Usha Rana
Diabetic foot ulcers (DFUs) occur in 15–25 % of diabetic patients at some point in their lifetime. The wide surgical debridement of the septic area is the cornerstone of diabetic foot ulcer treatment. There is a need to explore alternate therapies for DFU to reduce the risk of severe amputation. A 50-year-old male visited the Ayurveda OPD with a chronic ulcer on the plantar aspect of his right forefoot, which had persisted for two months. Ayurveda has considered Dushta vrana (∼septic nonhealing ulcer) and mentioned the Vrana upkrama (∼wound care measures) for its management. Among these Vrana upkrama, Jalauka avcharana (∼bloodletting using leech), Vrana Shodhana (∼wound cleansing measures) by Parisheka (∼therapeutic streaming of medicated decoction), Vrana ropana (∼wound-healing measures) are the three main wound care approaches along with Shamana (∼palliative therapy) for three months adopted in the present case for managing diabetic foot ulcers. DMIST tool was used to assess wound care at baseline and during follow-up. After three months of treatment, the integrated approach effectively shortens the healing time of DFUs, reduces the amputation rate and improves the standard of living of patients with DFUs with multiple Ayurvedic treatments.
{"title":"Healingwith integrative management of Diabetic foot ulcer - A case report","authors":"Rahul Katkar , Aadithyaraj K.T. , Usha Rana","doi":"10.1016/j.jaim.2025.101174","DOIUrl":"10.1016/j.jaim.2025.101174","url":null,"abstract":"<div><div>Diabetic foot ulcers (DFUs) occur in 15–25 % of diabetic patients at some point in their lifetime. The wide surgical debridement of the septic area is the cornerstone of diabetic foot ulcer treatment. There is a need to explore alternate therapies for DFU to reduce the risk of severe amputation. A 50-year-old male visited the Ayurveda OPD with a chronic ulcer on the plantar aspect of his right forefoot, which had persisted for two months. Ayurveda has considered <em>Dushta vrana</em> (∼septic nonhealing ulcer) and mentioned the <em>Vrana upkrama</em> (∼wound care measures) for its management. Among these <em>Vrana upkrama, Jalauka avcharana</em> (∼bloodletting using leech)<em>, Vrana Shodhana</em> (∼wound cleansing measures) by <em>Parisheka</em> (∼therapeutic streaming of medicated decoction)<em>, Vrana ropana</em> (∼wound-healing measures) are the three main wound care approaches along with <em>Shamana</em> (∼palliative therapy) for three months adopted in the present case for managing diabetic foot ulcers. DMIST tool was used to assess wound care at baseline and during follow-up. After three months of treatment, the integrated approach effectively shortens the healing time of DFUs, reduces the amputation rate and improves the standard of living of patients with DFUs with multiple Ayurvedic treatments.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101174"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-04DOI: 10.1016/j.jaim.2025.101203
Antonio Morandi , Maria Cristina Minniti , AN Narayanan Nambi
Modern pharmacology faces challenges in fully explaining inter-individual variability in drug efficacy and side effects. This article introduces a groundbreaking approach that applies Ayurvedic principles to interpret modern drug structures and actions, offering a more comprehensive framework for understanding drug behavior. Through the Collaborative Medicine and Science (Co.M.S.) framework, we demonstrate how Ayurvedic epistemology provides a holistic reading of modern pharmaceuticals using fundamental principles of Panchamahabhuta, Tridosha, and Guna. This Ayurvedic interpretation reveals how drug effects (Karma) emerge from the interaction between a substance's inherent qualities (Guna profile) and an individual's constitutional context (Prakriti/Vikriti), explaining inter-individual variability in drug responses. Illustrative examples using antibiotics and antihypertensives demonstrate how this approach can optimize prescription practices, reduce side effects, and lower healthcare costs. While empirical validation will strengthen this approach, it already offers valuable practical insights that complement—not replace—conventional pharmacology, potentially enhancing personalized medicine and patient outcomes.
{"title":"Translating Ayurvedic concepts to modern drug structures: A novel paradigm","authors":"Antonio Morandi , Maria Cristina Minniti , AN Narayanan Nambi","doi":"10.1016/j.jaim.2025.101203","DOIUrl":"10.1016/j.jaim.2025.101203","url":null,"abstract":"<div><div>Modern pharmacology faces challenges in fully explaining inter-individual variability in drug efficacy and side effects. This article introduces a groundbreaking approach that applies Ayurvedic principles to interpret modern drug structures and actions, offering a more comprehensive framework for understanding drug behavior. Through the Collaborative Medicine and Science (Co.M.S.) framework, we demonstrate how Ayurvedic epistemology provides a holistic reading of modern pharmaceuticals using fundamental principles of <em>Panchamahabhuta</em>, <em>Tridosha</em>, and <em>Guna</em>. This Ayurvedic interpretation reveals how drug effects (<em>Karma</em>) emerge from the interaction between a substance's inherent qualities (<em>Guna</em> profile) and an individual's constitutional context (<em>Prakriti</em>/<em>Vikriti)</em>, explaining inter-individual variability in drug responses. Illustrative examples using antibiotics and antihypertensives demonstrate how this approach can optimize prescription practices, reduce side effects, and lower healthcare costs. While empirical validation will strengthen this approach, it already offers valuable practical insights that complement—not replace—conventional pharmacology, potentially enhancing personalized medicine and patient outcomes.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101203"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.
Objective
To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders
Materials and Methods
A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India. The study included 29 consenting patients(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on changes in anthropometry and biochemical markers was analyzed using paired samples t-test.
Results
A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05). None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.
Conclusion
IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.
{"title":"Safety and potential utility of integrated Yoga and Ayurveda (IYA) intervention for psychotropic-associated metabolic syndrome in patients with severe mental disorders: A prospective single-arm pre-post pilot study","authors":"Chandrasenan Santhosh , Bhargav Hemant , Varambally Shivarama , Chikkanna Umesh , Jasti Nishitha , Suresh Meena Amritha , Ramakrishna Kishore Kumar","doi":"10.1016/j.jaim.2025.101198","DOIUrl":"10.1016/j.jaim.2025.101198","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders</div></div><div><h3>Materials and Methods</h3><div>A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India<em>. The study included 29 consenting patients</em>(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on <strong><em>changes in anthropometry and biochemical markers</em></strong> was analyzed using paired samples <em>t</em>-test.</div></div><div><h3>Results</h3><div><strong><em>A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05).</em></strong> None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.</div></div><div><h3>Conclusion</h3><div>IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101198"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barleria lupulina, a medicinal plant of India, South China and Southeast Asia, is known for its antioxidant and cytotoxic abilities. Although this plant has shown significant promise as an anticancer agent, the underlying mechanisms of action are yet to be explored. Objective: This study aimed to assess antiproliferative and proapoptotic potential of B. lupulina leaf extract with understanding of cellular and molecular mechanisms.
Materials and methods
The ethanolic extract was characterized using liquid chromatography-mass spectrometry and its anticancer activity was then assessed against Caco-2 colon cancer and A549 lung cancer cell lines.
Results
Phytochemical analysis of the extract revealed the presence of acetylbarlerin, decaffeoylacteoside, gallic acid, ipolamiide, leonuriside A, shanzhiside, and vanillic acid. The extract showed concentration-dependent cytotoxicity against both cancer cells. It induced early apoptosis at lower concentrations and late apoptosis at higher concentrations. Moreover, the extract noticeably reduced reactive oxygen species and mitochondrial membrane potential in a concentration-dependent way. The Western blot and quantitative reverse transcription polymerase chain reaction showed upregulation of Bax, caspase-8, caspase-9, and cluster of differentiation 95, and downregulation of Bcl-2. Molecular docking studies revealed that decaffeoylacteoside, gallic acid, and vanillic acid exhibited dual affinities for both caspase-8 and caspase-9, while acetylbarlerin, ipolamiide, leonuriside A, and shanzhiside showed selective affinities only for caspase-9.
Conclusion
The ethanolic leaf extract shows significant cytotoxic and proapoptotic activities, confirming its potential as a useful resource of bioactive compounds against cancer. Nevertheless, more in-depth investigations are necessary to realize the full potential of this medicinal plant for cancer therapy.
狼疮barleria lupina是印度、华南和东南亚的一种药用植物，以其抗氧化和细胞毒性而闻名。虽然这种植物已经显示出作为抗癌剂的重要前景，但其潜在的作用机制还有待探索。目的：研究狼疮叶提取物的抗增殖和促凋亡作用，探讨其细胞和分子机制。材料与方法采用液相色谱-质谱联用技术对乙醇提取物进行了表征，并对Caco-2结肠癌和A549肺癌细胞株进行了抑癌活性评价。结果植物化学分析显示，提取物中含有乙酰巴勒蛋白、脱咖啡因酰乳糖苷、没食子酸、异丙酰胺、枸橼酸苷A、山芝苷和香草酸。提取物对两种癌细胞的细胞毒性均呈浓度依赖性。低浓度诱导早期细胞凋亡，高浓度诱导晚期细胞凋亡。此外，提取物以浓度依赖性的方式显著降低活性氧和线粒体膜电位。Western blot和定量逆转录聚合酶链反应显示Bax、caspase-8、caspase-9、cluster of differentiation 95表达上调，Bcl-2表达下调。分子对接研究发现，脱咖啡酰乳糖苷、没食子酸和香草酸对caspase-8和caspase-9具有双重亲和力，而乙酰barlerin、ipolamide、leonuriside A和山芝苷仅对caspase-9具有选择性亲和力。结论乙醇提取物具有显著的细胞毒活性和促凋亡活性，具有开发抗癌活性物质的潜力。然而，为了充分发挥这种药用植物治疗癌症的潜力，还需要进行更深入的研究。
{"title":"Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment","authors":"Sabyasachi Banerjee , Avik Das , Sankhadip Bose , Subhasis Banerjee , Anusha Bishayee , Anupam Bishayee","doi":"10.1016/j.jaim.2025.101220","DOIUrl":"10.1016/j.jaim.2025.101220","url":null,"abstract":"<div><h3>Background</h3><div><em>Barleria lupulina</em>, a medicinal plant of India, South China and Southeast Asia, is known for its antioxidant and cytotoxic abilities. Although this plant has shown significant promise as an anticancer agent, the underlying mechanisms of action are yet to be explored. <em><strong>Objective</strong></em><strong>:</strong> This study aimed to assess antiproliferative and proapoptotic potential of <em>B. lupulina</em> leaf extract with understanding of cellular and molecular mechanisms.</div></div><div><h3>Materials and methods</h3><div>The ethanolic extract was characterized using liquid chromatography-mass spectrometry and its anticancer activity was then assessed against Caco-2 colon cancer and A549 lung cancer cell lines.</div></div><div><h3>Results</h3><div>Phytochemical analysis of the extract revealed the presence of acetylbarlerin, decaffeoylacteoside, gallic acid, ipolamiide, leonuriside A, shanzhiside, and vanillic acid. The extract showed concentration-dependent cytotoxicity against both cancer cells. It induced early apoptosis at lower concentrations and late apoptosis at higher concentrations. Moreover, the extract noticeably reduced reactive oxygen species and mitochondrial membrane potential in a concentration-dependent way. The Western blot and quantitative reverse transcription polymerase chain reaction showed upregulation of Bax, caspase-8, caspase-9, and cluster of differentiation 95, and downregulation of Bcl-2. Molecular docking studies revealed that decaffeoylacteoside, gallic acid, and vanillic acid exhibited dual affinities for both caspase-8 and caspase-9, while acetylbarlerin, ipolamiide, leonuriside A, and shanzhiside showed selective affinities only for caspase-9.</div></div><div><h3>Conclusion</h3><div>The ethanolic leaf extract shows significant cytotoxic and proapoptotic activities, confirming its potential as a useful resource of bioactive compounds against cancer. Nevertheless, more in-depth investigations are necessary to realize the full potential of this medicinal plant for cancer therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101220"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-22DOI: 10.1016/j.jaim.2025.101180
Anusha Seelamantula , Premarajan K C , Mahalakshmy Thulasingam
Background
The rising popularity of alternative medicine positions AYUSH (Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy) systems as valuable tools for providing affordable, culturally appropriate healthcare to low-middle-income countries. However, overcoming the challenges of scaling up these traditional systems is key to gaining broader acceptance of this promising healthcare approach.
Objectives
To determine the prevalence and associated factors of AYUSH utilization. And, to explore the perceptions of AYUSH providers on factors supporting or hindering AYUSH adoption, and its integration with conventional medicine.
Material and methods
A concurrent mixed-method study was employed between September and December 2023. Prevalence of AYUSH utilization was assessed via door-to-door survey using pre-tested questionnaire. Ten key informant interviews were conducted among AYUSH practitioners and analyzed using thematic analysis.
Results
Prevalence of AYUSH utilization was 19.2% (95% CI:16.9% – 21.6%). A significant association among people with comorbidities (aPR: 1.5; 95% CI: 1.0–2.1; P-value<0.05) is observed. Qualitative analysis revealed that growing public interest and government support were key enablers, while limited scientific validation and workforce shortage were major barriers. From the health systems perspective, AYUSH providers spoke about the need for policy and governance reforms to create a more unified healthcare system.
Conclusion
Despite some challenges, the findings suggest that AYUSH is increasingly favoured for its natural approach. A growing acceptance of integrative medicine highlights the need for cohesive care models and improved accessibility. The study emphasizes the importance of addressing state-specific needs and standardizing AYUSH practices to facilitate integration.
{"title":"Unravelling AYUSH providers’ perspectives on healthcare choices of people residing in urban areas of Puducherry, India- A concurrent mixed method study","authors":"Anusha Seelamantula , Premarajan K C , Mahalakshmy Thulasingam","doi":"10.1016/j.jaim.2025.101180","DOIUrl":"10.1016/j.jaim.2025.101180","url":null,"abstract":"<div><h3>Background</h3><div>The rising popularity of alternative medicine positions AYUSH (Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy) systems as valuable tools for providing affordable, culturally appropriate healthcare to low-middle-income countries. However, overcoming the challenges of scaling up these traditional systems is key to gaining broader acceptance of this promising healthcare approach.</div></div><div><h3>Objectives</h3><div>To determine the prevalence and associated factors of AYUSH utilization. And, to explore the perceptions of AYUSH providers on factors supporting or hindering AYUSH adoption, and its integration with conventional medicine.</div></div><div><h3>Material and methods</h3><div>A concurrent mixed-method study was employed between September and December 2023. Prevalence of AYUSH utilization was assessed via door-to-door survey using pre-tested questionnaire. Ten key informant interviews were conducted among AYUSH practitioners and analyzed using thematic analysis.</div></div><div><h3>Results</h3><div>Prevalence of AYUSH utilization was 19.2% (95% CI:16.9% – 21.6%). A significant association among people with comorbidities (aPR: 1.5; 95% CI: 1.0–2.1; <em>P</em>-value<0.05) is observed. Qualitative analysis revealed that growing public interest and government support were key enablers, while limited scientific validation and workforce shortage were major barriers. From the health systems perspective, AYUSH providers spoke about the need for policy and governance reforms to create a more unified healthcare system.</div></div><div><h3>Conclusion</h3><div>Despite some challenges, the findings suggest that AYUSH is increasingly favoured for its natural approach. A growing acceptance of integrative medicine highlights the need for cohesive care models and improved accessibility. The study emphasizes the importance of addressing state-specific needs and standardizing AYUSH practices to facilitate integration.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101180"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a chronic skin disorder with a substantial global burden, affecting over 100 million people worldwide. Conventional treatments, including topical and systemic therapies, have their own limitations and side effects. Siddha medicine, deeply rooted with comprehensive principles, offers an alternative approach in Psoriasis management. This randomized controlled trial aims to explore the safety and efficacy of Sivanarvembu Kuzhithailam, a classical Siddha medicine in the management of Psoriasis.
Objectives
The primary objective of this RCT is to determine the safety and efficacy of Sivanarvembu Kuzhithailam (SVK) and Vetpalai thailam and to reduce the PASI score in Psoriasis patients significantly. The secondary objective involves validating the biochemical changes in the study participants and determining enhancements in their quality of life before and after treatment. As a result, specific inflammatory markers, proteins, antioxidants, and assessments of oxidative stress have been undertaken in this clinical trial to provide deeper insights into the extent of inflammation, disease severity, and the mechanisms of action of the trial drug.
Methods
This is a single center, open-label, parallel group, exploratory randomized controlled trial with a sample size of 90 and with the objective of determining the safety and efficacy of Sivanarvembu Kuzhithailam in the management of psoriasis. This study protocol followed the SPIRIT 2013 guidelines.
Result
The primary outcome is to measure the reduction in the Psoriasis Area and Severity Index (PASI) score from baseline to 91 days and safety parameters. Secondary outcomes include the evaluation of enhancements in participants' quality of life through the assessment of the Dermatology Life Quality Index, as well as the examination of antioxidant levels, inflammatory markers, biochemical markers, in blood samples of trial participants.
Conclusion
The outcome of the study can be extrapolated to the next level of clinical trials with larger populations to provide robust scientific evidence for this traditional Siddha formulation for global acceptance.
{"title":"A randomized controlled study protocol to determine the safety and efficacy of Sivanarvembu Kuzhithailam in the management of Psoriasis (Kalanjagapadai)","authors":"Rathinamala Rathinam , Gayathri Gunalan , Lavanya Alagusolaiyan , Vinu Bharathi Balasubramaniam , Rajendra Kumar Arumugam , Sathiyarajeswaran Parameswaran","doi":"10.1016/j.jaim.2025.101191","DOIUrl":"10.1016/j.jaim.2025.101191","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic skin disorder with a substantial global burden, affecting over 100 million people worldwide. Conventional treatments, including topical and systemic therapies, have their own limitations and side effects. Siddha medicine, deeply rooted with comprehensive principles, offers an alternative approach in Psoriasis management. This randomized controlled trial aims to explore the safety and efficacy of <em>Sivanarvembu Kuzhithailam</em>, a classical Siddha medicine in the management of Psoriasis.</div></div><div><h3>Objectives</h3><div>The primary objective of this RCT is to determine the safety and efficacy of Sivanarvembu Kuzhithailam (SVK) and Vetpalai thailam and to reduce the PASI score in Psoriasis patients significantly. The secondary objective involves validating the biochemical changes in the study participants and determining enhancements in their quality of life before and after treatment. As a result, specific inflammatory markers, proteins, antioxidants, and assessments of oxidative stress have been undertaken in this clinical trial to provide deeper insights into the extent of inflammation, disease severity, and the mechanisms of action of the trial drug.</div></div><div><h3>Methods</h3><div>This is a single center, open-label, parallel group, exploratory randomized controlled trial with a sample size of 90 and with the objective of determining the safety and efficacy of Sivanarvembu Kuzhithailam in the management of psoriasis. This study protocol followed the SPIRIT 2013 guidelines.</div></div><div><h3>Result</h3><div>The primary outcome is to measure the reduction in the Psoriasis Area and Severity Index (PASI) score from baseline to 91 days and safety parameters. Secondary outcomes include the evaluation of enhancements in participants' quality of life through the assessment of the Dermatology Life Quality Index, as well as the examination of antioxidant levels, inflammatory markers, biochemical markers, in blood samples of trial participants.</div></div><div><h3>Conclusion</h3><div>The outcome of the study can be extrapolated to the next level of clinical trials with larger populations to provide robust scientific evidence for this traditional Siddha formulation for global acceptance.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101191"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-29DOI: 10.1016/j.jaim.2025.101187
Praveen Balakrishnan, Emy S. Surendran, G.N. Sree Deepthi, A. Abhayadev, Lisha S. Raj
A 35-year-old male patient, who is non-diabetic, non-dyslipidemic, normotensive, and euthyroid, and works as a hotel manager, visited our outpatient department with complaints of two ulcers on the inner side of his right lower leg, which developed rapidly after intense itching for about a week due to scratching. The ulcers were clean, had granulation tissue, caused mild pain, showed no discharge, and were surrounded by dark discolouration. The patient's history indicated that he had experienced severe itching in that area for four to five years, along with recurrent fevers, which began after being bitten by an unidentified type of black ant. The Bates Jensen wound assessment tool scored 33 for the larger wound and 27 for the smaller wound. Initially, the patient received some Ayurvedic treatments aimed at promoting healing for approximately 40 days, but these did not improve. A venous Doppler ultrasound of his right leg indicated chronic venous insufficiency. Given the persistent nature of the ulcers despite medical treatment, the condition was diagnosed as Dooshi Vishajanya Vrana over chronic venous insufficiency. Therefore, a single session of Jalaukavacharana was performed using three Jalaukas on the ulcer site, which healed within one week of the treatment. After the treatment, the Bates Jensen wound assessment scores improved to 18 for the larger wound and 17 for the smaller wound. Follow-up evaluations conducted after four months and one year revealed no recurrence of the ulcers. The dark discolouration of the leg began to diminish from the fourth month of the follow-up period.
{"title":"Complete healing of a Dooshivishajanya non-healing wound with Jalaukavacharana - A case report","authors":"Praveen Balakrishnan, Emy S. Surendran, G.N. Sree Deepthi, A. Abhayadev, Lisha S. Raj","doi":"10.1016/j.jaim.2025.101187","DOIUrl":"10.1016/j.jaim.2025.101187","url":null,"abstract":"<div><div>A 35-year-old male patient, who is non-diabetic, non-dyslipidemic, normotensive, and euthyroid, and works as a hotel manager, visited our outpatient department with complaints of two ulcers on the inner side of his right lower leg, which developed rapidly after intense itching for about a week due to scratching. The ulcers were clean, had granulation tissue, caused mild pain, showed no discharge, and were surrounded by dark discolouration. The patient's history indicated that he had experienced severe itching in that area for four to five years, along with recurrent fevers, which began after being bitten by an unidentified type of black ant. The Bates Jensen wound assessment tool scored 33 for the larger wound and 27 for the smaller wound. Initially, the patient received some Ayurvedic treatments aimed at promoting healing for approximately 40 days, but these did not improve. A venous Doppler ultrasound of his right leg indicated chronic venous insufficiency. Given the persistent nature of the ulcers despite medical treatment, the condition was diagnosed as <em>Dooshi Vishajanya Vrana</em> over chronic venous insufficiency. Therefore, a single session of <em>Jalaukavacharana</em> was performed using three <em>Jalaukas</em> on the ulcer site, which healed within one week of the treatment. After the treatment, the Bates Jensen wound assessment scores improved to 18 for the larger wound and 17 for the smaller wound. Follow-up evaluations conducted after four months and one year revealed no recurrence of the ulcers. The dark discolouration of the leg began to diminish from the fourth month of the follow-up period.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101187"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-30DOI: 10.1016/j.jaim.2025.101188
Guruprasad C. Nille , Monisha Bhuyan , Laxmi Narayan Gupta , Mohd Ali , Chandra Shekhar Pati Tripathi , Omkar S. Nille , Shardendu Kumar Mishra , Anuja Vibhute , Pranoti Kamble , Himanshu Ranjan , Amaresh Kumar Singh , Arpita P-Tiwari , Anand Kumar Chaudhary
Background
Yashad Bhasma (YB), the incinerated metal ash of zinc, has been used for centuries in Ayurveda to address a variety of conditions, including eye diseases, diabetes mellitus, anemia, respiratory illnesses, etc.
Objective
This research aimed to synthesize and characterize YB and to evaluate its potential antimicrobial, antioxidant, and anti-angiogenic activities.
Materials and methods
In this study, YB is synthesized by optimizing the traditional method. Morphological and physicochemical characterization are performed using XRD, XPS, SEM, TEM, EDAX, DLS, TGA-DSC, and FTIR. The antimicrobial activity of YB is assessed using the well diffusion technique against the gram-positive bacterium Staphylococcus aureus (S. aureus) and the gram-negative bacterium Escherichia coli (E. coli). The antioxidant potential is evaluated using the 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) radical scavenging assay and Nitric oxide (NO) radical scavenging assay. A chick chorioallantoic membrane (CAM) assay is performed on fertilized chick eggs to study the anti-angiogenesis potential of YB.
Results
The XRD patterns of YB showed the presence of cubic and hexagonal phases of ZnS having average crystallite size of 32.66 nm. XPS data supports the formation of ZnS phase of YB. SEM and TEM data confirmed the size of YB NPs in a range of 250–350 nm. The EDAX analysis confirmed the presence of Zn (37.2 %) and S (21.18 %). The mean particle diameter was 361 nm in DLS. TGA-DSC findings verified that the synthesized material is stable up to 435.80 °C. The FTIR confirms the presence of organic moieties in YB along with ZnS phase. YB effectively inhibited the growth of S. aureus and E. coli. The ability of YB to scavenge DPPH and NO radicals is found to be concentration dependent (50–250 μg/mL). The study also demonstrated that YB has notable antioxidant activity. The disappearance of blood vessels beneath the sample-loaded disk after 7 days indicated the effective anti-angiogenic properties of YB.
Conclusion
Altogether, YB exhibited significant antimicrobial, noteworthy antioxidant, and anti-angiogenic activities, indicating its potential as a promising therapeutic agent.
{"title":"Characterization and potential novel applications of zinc-based traditional medicine, Yashad Bhasma","authors":"Guruprasad C. Nille , Monisha Bhuyan , Laxmi Narayan Gupta , Mohd Ali , Chandra Shekhar Pati Tripathi , Omkar S. Nille , Shardendu Kumar Mishra , Anuja Vibhute , Pranoti Kamble , Himanshu Ranjan , Amaresh Kumar Singh , Arpita P-Tiwari , Anand Kumar Chaudhary","doi":"10.1016/j.jaim.2025.101188","DOIUrl":"10.1016/j.jaim.2025.101188","url":null,"abstract":"<div><h3>Background</h3><div><em>Yashad Bhasma</em> (YB), the incinerated metal ash of zinc, has been used for centuries in Ayurveda to address a variety of conditions, including eye diseases, diabetes mellitus, anemia, respiratory illnesses, etc.</div></div><div><h3>Objective</h3><div>This research aimed to synthesize and characterize YB and to evaluate its potential antimicrobial, antioxidant, and anti-angiogenic activities.</div></div><div><h3>Materials and methods</h3><div>In this study, YB is synthesized by optimizing the traditional method. Morphological and physicochemical characterization are performed using XRD, XPS, SEM, TEM, EDAX, DLS, TGA-DSC, and FTIR. The antimicrobial activity of YB is assessed using the well diffusion technique against the gram-positive bacterium <em>Staphylococcus aureus (S. aureus)</em> and the gram-negative bacterium <em>Escherichia coli</em> (<em>E. coli</em>). The antioxidant potential is evaluated using the 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) radical scavenging assay and Nitric oxide (NO) radical scavenging assay. A chick chorioallantoic membrane (CAM) assay is performed on fertilized chick eggs to study the anti-angiogenesis potential of YB.</div></div><div><h3>Results</h3><div>The XRD patterns of YB showed the presence of cubic and hexagonal phases of ZnS having average crystallite size of 32.66 nm. XPS data supports the formation of ZnS phase of YB. SEM and TEM data confirmed the size of YB NPs in a range of 250–350 nm. The EDAX analysis confirmed the presence of Zn (37.2 %) and S (21.18 %). The mean particle diameter was 361 nm in DLS. TGA-DSC findings verified that the synthesized material is stable up to 435.80 °C. The FTIR confirms the presence of organic moieties in YB along with ZnS phase. YB effectively inhibited the growth of <em>S. aureus</em> and <em>E. coli</em>. The ability of YB to scavenge DPPH and NO radicals is found to be concentration dependent (50–250 μg/mL). The study also demonstrated that YB has notable antioxidant activity. The disappearance of blood vessels beneath the sample-loaded disk after 7 days indicated the effective anti-angiogenic properties of YB.</div></div><div><h3>Conclusion</h3><div>Altogether, YB exhibited significant antimicrobial, noteworthy antioxidant, and anti-angiogenic activities, indicating its potential as a promising therapeutic agent.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101188"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号