Journal of Ayurveda and Integrative Medicine最新文献_第3页

Symposium proceedings on ‘Samaakalan: The Ayush integration into modern medicine in health and disease’ 关于“Samaakalan：阿尤什在健康和疾病方面融入现代医学”的研讨会论文集。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jaim.2025.101289

Priyanka Singh , Kavita Thaker , Manohar Gundeti , Archana Kumari Redhu , Dattatraya Dighe , Govind Reddy , Vikram Gota

引用次数: 0

Potential anticancer activity of Shulva Yoga, a herbo-metallic compound, in loss of scrib induced cancer in Drosophila melanogaster 舒尔瓦瑜伽，一种草药-金属化合物，在果蝇诱导的癌症损失中的潜在抗癌活性。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jaim.2025.101292

Shiwakshi Sharma , Namrata Joshi , Saripella Srikrishna , Konduru Rama Chandra Reddy , Partha Pratim Manna , Manoj Kumar Dash , Pankaj Kumar , Remya Jayakumar , Jyotsna Singh

Background:The worldwide burden of cancer is illustrated by the 10.0 million fatalities (World Health Organization, 2021) and the 19.3 million incidence of new cases as reported in the GLOBOCAN data. The transparency to sensitiveness of chromosomal aberrations and the consequent responses in epithelial cancer quotients collectively explains the need of tumor exploration in Drosophila models.

Objective: The reciprocation of a traditional herb-mineral combination Shulva Yoga (SY) in epithelial tumour microenvironment has been fundamentally assessed here.

Material and methods:Classically incinerated copper ash were mixed for levigation with madyantika (Lawsonia inermisL.), punarnava (Boerhaavia diffusaL.) and meshshringi[Gymnema sylvestre (Retz.) Schult.] leaves. The in-vitro analysis of MTT and AnnexinV/PI staining were applied on four different cell lines (DL, JE6.1, MCF-7,& WRL-68) with SY. The in-vivo analysis was initiated with loss of scribble (cell polarity protein) in wing imaginal disc of Drosophila melanogaster for epithelial carcinoma induction. The dose determination was followed with pupal lethality assessment and anti-oxidant levels. The Phalloidin/F-actin filament, DAPI and Immunostaining were further implied.

Results:The IC50 of SY treated DL, JE6.1, MCF-7 and WRL-68 cells at 24 hours was 28.25±1.5 μg, 27.27±1.6 μg, 37.59±1.9 μg, 15.92±2.5 μg respectively. The dosedependent range of 0.01 mg/ml to 0.2 mg/ml exhibited the features of early and late apoptosis after 24hrs with AnnexinV/PI stain. SY showed early pupal rescue, preservation of Actin filaments, downregulation of MMP 1and cyclin-E in comparison to the untreated. There was surge of the SOD and catalase levels, whereas LPO content depressed.

Conclusion:SY might induce apoptosis in tumour cells with counter mechanisms on angiogenesis, proliferation and metastasis in Drosophila model. Gene amplification, protein specificity, etc are the future prospects of present work.

背景：GLOBOCAN数据中报告的1000万例死亡（世界卫生组织，2021年）和1930万例新发病例说明了全球癌症负担。染色体畸变敏感性的透明度和随之而来的上皮癌商反应共同解释了在果蝇模型中肿瘤探索的必要性。目的：本文从根本上评估了传统的草药-矿物质组合舒尔瓦瑜伽（Shulva Yoga， SY）在上皮肿瘤微环境中的相互作用。材料和方法：传统的焚烧铜灰与madyantika (Lawsonia inermisL.), punarnava （Boerhaavia diffusaL.）和meshshringi (Gymnema sylvestre （Retz.）混合在一起进行航行。Schult。叶子。采用MTT和AnnexinV/PI染色对4种不同的细胞系（DL、JE6.1、MCF-7和WRL-68）进行体外分析。活体分析开始于黑腹果蝇（Drosophila melanogaster）翅膀成像盘中scribble（细胞极性蛋白）的缺失，以诱导上皮癌。剂量测定后进行蛹致死性评价和抗氧化水平测定。进一步测定Phalloidin/F-actin丝、DAPI和免疫染色。结果：SY对DL、JE6.1、MCF-7、WRL-68细胞24 h的IC50分别为28.25±1.5 μg、27.27±1.6 μg、37.59±1.9 μg、15.92±2.5 μg。AnnexinV/PI染色在0.01 mg/ml ~ 0.2 mg/ml剂量依赖性范围内，24h后细胞呈现早、晚凋亡特征。与未处理组相比，SY组表现出早期的蛹恢复、肌动蛋白丝的保存、mmp1和cyclin-E的下调。SOD和过氧化氢酶含量显著升高，LPO含量显著降低。结论：SY诱导肿瘤细胞凋亡可能具有抑制果蝇血管生成、增殖和转移的机制。基因扩增、蛋白特异性等是目前工作的未来前景。

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引用次数: 0

Oral administration of osimertinib mesylate induced multiple peripheral neuropathy of a non-small-cell lung cancer patient and treated with traditional Chinese medicine - A case report 口服甲磺酸奥西替尼诱导非小细胞肺癌患者多发性周围神经病变1例并辅以中药治疗。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2025-12-22 DOI: 10.1016/j.jaim.2025.101225

Xiange Huang , Hegen Li , Ziming Li , Yilin Yao

Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.

甲磺酸奥希替尼（OM）是第三代表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI），用于靶向治疗非小细胞肺癌（NSCLC）。迄今为止，临床已报道OM的一些不良反应（如横纹肌溶解、严重皮疹等），但未见OM引起的多发性周围神经病变（MPN）的病例。在此，我们报告一例罕见的口服om诱导的非小细胞肺癌患者的MPN并以中药汤剂治疗的病例。在口服OM治疗NSCLC 2个月后，一名70岁男性出现MPN症状，包括手脚麻木，双下肢无力，活动受限，最终丧失站立和行走能力。同时，其他已知的MPN原因也被排除。停用口服OM 24天后症状未见改善。随后每日口服中医辨证汤剂。1个月后，患者的MPN症状减轻，总神经病评分（TNS）明显降低。他在助行器的帮助下能够站立和行走。辨证中药汤剂是缓解甚至消除MPN症状的可行治疗方案。om诱导的MPN的机制和预防策略有待进一步研究。

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引用次数: 0

Effect of an integrated Yoga module on clinical, endocrine and metabolomic outcomes in polycystic ovarian syndrome 综合瑜伽模块对多囊卵巢综合征临床、内分泌和代谢结果的影响

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jaim.2025.101294

Deepika Kumari , Reeta Mahey , Neena Malhotra , Rima Dada

Polycystic ovarian syndrome (PCOS) affects 5–20 % of women of reproductive age, with reproductive, metabolic, endocrine, and psychological consequences. Lifestyle interventions such as yoga provide safe, low-cost, and sustainable therapy. In this study, 25 women with PCOS underwent a 12-week yoga program (Asanas, Pranayama, Meditation) without concurrent therapy. Yoga improved menstrual regularity, normalized hormonal and metabolomic profiles. Biochemical analysis revealed reduced oxidative stress, enhanced mitochondrial function, improved insulin signaling, and decreased inflammation. Hormonal assays showed reduced luteinizing hormone (LH), anti-Müllerian hormone (AMH), dihydrotestosterone (DHT), and testosterone, with increased follicle-stimulating hormone (FSH), estradiol, and sex hormone-binding globulin (SHBG). Metabolomic improvements included reductions in glucose, fructose, d-ribose, xanthine, cholesterol, triglycerides, and body weight. These findings highlight yoga's potential to target core PCOS pathophysiology and support its use as a cost-effective, non-pharmacological, and sustainable therapy inn management of PCOS.

多囊卵巢综合征（PCOS）影响5- 20%的育龄妇女，对生殖、代谢、内分泌和心理造成影响。瑜伽等生活方式干预提供了安全、低成本和可持续的治疗。在这项研究中，25名患有多囊卵巢综合征的女性接受了为期12周的瑜伽课程（体式、调息、冥想），没有同时进行治疗。瑜伽改善了月经规律，使荷尔蒙和代谢谱正常化。生化分析显示氧化应激降低，线粒体功能增强，胰岛素信号改善，炎症减少。激素检测显示黄体生成素（LH）、抗勒根激素（AMH）、二氢睾酮（DHT）和睾酮降低，促卵泡激素（FSH）、雌二醇和性激素结合球蛋白（SHBG）升高。代谢组学的改善包括葡萄糖、果糖、d-核糖、黄嘌呤、胆固醇、甘油三酯和体重的减少。这些发现强调了瑜伽针对多囊卵巢综合征核心病理生理的潜力，并支持其作为多囊卵巢综合征管理中具有成本效益，非药物和可持续的治疗方法的使用。

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引用次数: 0

Need for a centralized repository of standardized validated scales and disease gradation tools for clinical research in Ayurveda 阿育吠陀临床研究需要一个标准化的验证量表和疾病分级工具的集中存储库

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jaim.2025.101271

Urmila J. Shirke , Payal P. Wavhal

引用次数: 0

Tribulus terrestris L. confers protection against hypoxia induced pulmonary hypertension via regulation of HIF/ NF-κB signalling pathway 蒺藜通过调控HIF/ NF-κB信号通路对缺氧诱导的肺动脉高压具有保护作用。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jaim.2025.101296

Yashesvi Ambardar, Sheema Wazib, Sher Afghan, Md Iqbal Alam

Background

Pulmonary hypertension (PH) is a fatal cardiopulmonary disorder driven by hypoxia-induced vascular remodeling. The hypoxic pulmonary vasoconstriction (HPV) and increased pulmonary vascular resistance leads right ventricular failure and ultimately death. Limited therapies and poor prognosis demand novel interventions. Tribulus terrestris L., renowned for antioxidant and anti-inflammatory effects, may modulate various pathways of hypoxia induced pulmonary hypertension pathogenesis.

Objective

This study examines potential of T. terrestris to counter hypoxia-induced PH in a rodent model via HIF–NF-κB signalling.

Material and methods

Thirty male Wistar rats were randomly undertaken, 6 rats were utilized for standardization of drug dose (T. terrestris) and remaining 24 were divided into 4 groups with 6 animals in each group as normal control, pulmonary hypertension due to intermittent hypoxia, pulmonary hypertension due to intermittent hypoxia + Tadalafil drug, pulmonary hypertension due to intermittent hypoxia + T. terrestris 250 mg/kg. Right ventricular systolic pressure (RVSP), serum levels of reactive oxygen species (ROS), nitric oxide (NO),inducible nitric oxide synthase (iNOS) and inflammatory markers-hypoxia inducible factor-1α (HIF-1α), nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in all the groups were analysed.

Results

Administration of crude T. terrestris extract to hypoxic pulmonary hypertensive rats significantly reduced RVSP, ROS, NO, iNOS, and inflammatory markers. No significant difference in therapeutic outcomes was observed between T. terrestris and tadalafil treatment groups.

Conclusion

T. terrestris exhibits biochemical and hemodynamic changes associated with marked improvement in pulmonary hypertension indicating strong anti-oxidative, anti-inflammatory, and anti-angiogenic effects. This is the first study to report the protective effects of T. terrestris against hypoxic pulmonary hypertension.

背景：肺动脉高压（PH）是一种由缺氧引起的血管重构引起的致命性心肺疾病。缺氧性肺血管收缩（HPV）和肺血管阻力增加导致右心室衰竭和最终死亡。有限的治疗和不良的预后需要新的干预措施。蒺藜具有抗氧化和抗炎作用，可以调节缺氧引起的肺动脉高压的多种发病途径。目的：研究地鼠通过HIF-NF-κB信号传导对抗缺氧诱导的PH值的潜力。材料与方法：随机选取雄性Wistar大鼠30只，其中6只进行给药剂量标准化，其余24只随机分为4组，每组6只作为正常对照，间歇性缺氧致肺动脉高压、间歇性缺氧致肺动脉高压+他他拉非药物、间歇性缺氧致肺动脉高压+他他拉非药物250 mg/kg。分析各组右心室收缩压（RVSP）、血清活性氧（ROS）、一氧化氮（NO）、诱导型一氧化氮合酶（iNOS）及炎症标志物缺氧诱导因子-1α (HIF-1α)、核因子-κB （NF-κB）、环氧化酶-2 （COX-2）、血管内皮生长因子（VEGF）水平。结果：对低氧肺动脉高压大鼠给予地黄粗提物可显著降低RVSP、ROS、NO、iNOS及炎症标志物。两组治疗效果无显著性差异。结论：地草具有明显改善肺动脉高压的生化和血流动力学变化，具有较强的抗氧化、抗炎和抗血管生成作用。本研究首次报道了地衣对低氧性肺动脉高压的保护作用。

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引用次数: 0

A novel effective treatment for skin abscess using traditional Chinese herbal medicine: a case series 中药治疗皮肤脓肿的一种新的有效方法：一个病例系列

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jaim.2025.101285

Liang-Jun Lu , Xin-Yi Lu , Xiu-Zu Song , Ai-E Xu

Skin abscess is a common bacterial infection of the skin and soft tissues. Conventional treatment typically involves incision and drainage after pus formation, which may lead to prolonged healing and surgical scarring. Traditional Chinese Medicine (TCM) has extensive experience in treating infectious diseases with the potential for rapid recovery and minimal scarring; however, international literature on its efficacy remains limited. We present three cases of skin abscess successfully treated with an oral modified Xian Fang Huo Ming Yin (XFHMY) decoction based on syndrome differentiation.

Case 1

A 29-year-old male presented with a painful, swollen plaque on the left upper back persisting for over two weeks.

Case 2

A 12-year-old girl with a red, swollen mass on the left waist for more than 10 days.

Case 3

A 35-year-old male with a painful, erythematous plaque on the inner right upper arm for half a month.

After 5–7 days of TCM treatment, all abscesses resolved completely without significant scarring, and only mild hyperpigmentation or depression remained. These findings suggest that TCM, particularly modified XFHMY, may serve as an effective non-invasive alternative therapy for skin abscesses.

皮肤脓肿是一种常见的皮肤和软组织细菌感染。传统的治疗通常包括在脓形成后切开引流，这可能导致愈合时间延长和手术疤痕。中医（TCM）在治疗传染病方面有丰富的经验，具有快速恢复和最小疤痕的潜力；然而，关于其功效的国际文献仍然有限。本文报告以中医辨证论治为主，口服显方活血饮加减方治疗皮肤脓肿3例。病例1A， 29岁男性，左上背部疼痛肿胀斑块持续2周以上。病例2A， 12岁女孩，左腰红肿肿块持续10多天。病例3A， 35岁男性，右上臂内侧有疼痛的红斑斑块半个月。中药治疗5-7天后，所有脓肿完全消退，无明显瘢痕形成，仅残留轻度色素沉着或抑郁。这些发现表明，中药，特别是改良的XFHMY，可能作为一种有效的非侵入性皮肤脓肿替代疗法。

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引用次数: 0

Signaling pathways and molecular mechanisms of lupeol in colorectal cancer: A comprehensive review lupeol在结直肠癌中的信号通路和分子机制综述

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jaim.2025.101270

Mohd Asad Farooqi, Kantrol Kumar Sahu

Colorectal cancer (CRC) is a serious worldwide health concern associated with chronic inflammation and dysregulation of numerous signaling pathways, including IL-6/STAT3, NF-κB, COX-2/PGE2, and IL-23/Th17. These pathways aid in tumour development and progression by increasing the manufacture of inflammatory mediators, anti-apoptotic gene expression, cell proliferation, and angiogenesis. Lupeol, a naturally occurring lupine-type pentacyclic triterpenoid, has sparked widespread interest due to its several pharmacological qualities, which include antioxidant, anti-inflammatory, anticancer, and antibacterial capabilities. Despite its enormous medicinal promise, low water solubility and bioavailability have hampered its clinical use. Recent advances in nano-based delivery systems and the invention of lupeol derivatives have increased its bioavailability and bioactivity, making it a promising candidate for CRC treatment. This study seeks to inspire additional research into lupeol's significance as a nutraceutical intervention in CRC by integrating current knowledge and investigating novel techniques to increase its clinical efficacy.

结直肠癌（CRC）是一种严重的全球性健康问题，与慢性炎症和多种信号通路失调有关，包括IL-6/STAT3、NF-κB、COX-2/PGE2和IL-23/Th17。这些途径通过增加炎症介质的制造、抗凋亡基因表达、细胞增殖和血管生成来帮助肿瘤的发展和进展。羽扇豆醇是一种天然存在的羽扇豆素型五环三萜，由于其多种药理特性，包括抗氧化、抗炎、抗癌和抗菌能力，引起了广泛的兴趣。尽管其具有巨大的药用前景，但低水溶性和生物利用度阻碍了其临床应用。纳米递送系统的最新进展和芦荚醇衍生物的发明提高了其生物利用度和生物活性，使其成为治疗结直肠癌的有希望的候选药物。本研究旨在通过整合现有知识和研究新技术来提高其临床疗效，从而激发对芦皮醇作为CRC营养干预的意义的进一步研究。

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引用次数: 0

Potential benefits of Ayurveda in Duchenne muscular Dystrophy: A case based analysis 阿育吠陀治疗杜氏肌营养不良症的潜在益处：基于案例的分析。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-03 DOI: 10.1016/j.jaim.2025.101272

Manchal Shivappa Puja, Kothanath Bhaskaran Jyothy, Varuni Kulkarni, S. Srihari

Duchenne Muscular Dystrophy is a debilitating X-linked genetic disorder that manifests in early childhood with progressive muscle weakness, loss of ambulation, and ultimately, respiratory and cardiac failure resulting in premature mortality. A nine-year-old male patient presented with the inability to stand and ambulate without assistance, which had persisted since six years of age. He had been previously diagnosed with Duchenne Muscular Dystrophy, and his parents provided the relevant diagnostic documents. The patient exhibited weakness in the lower extremities, poor appetite, irregular bowel habits, and irritability. The clinical manifestations were evaluated from an Ayurvedic perspective, and a corresponding treatment plan was subsequently devised. The treatment regimen spanned 4 months, consisting of 6 sessions with an interval of 15–20 days between each clinical visit. The therapeutic approach encompassed major interventions such as external and internal Swedana, Basti, and oral medications. Concurrently, internal medications and appropriate dietary modifications were incorporated. The internal medications included herbs like Sida cordifolia L, Withania somnifera, Terminalia chebula Retz, Bacopa monneri, and Zingiber officinale Roxb. Additional herbs with proven Immunomodulatory, Antioxidant, and Anti-Inflammatory properties were also utilized. Physiotherapy was continued as part of the overall management strategy.

Following the third treatment session, the child exhibited the ability to stand with the support of a cot, grasp and throw a stone - abilities that were not previously observed prior to the therapies. Additionally, by the end of the first month, improvements were noted in the patient's appetite and bowel habits. The comprehensive Ayurvedic approach, when combined with physiotherapy, demonstrated enhancements in symptoms such as relief from constipation, the capacity to stand with cot support, subtle changes in the upper limb muscle tone, and an overall enhancement in the child's quality of life. This study highlights the potential of Ayurveda as a complementary approach to conventional treatment.

杜氏肌营养不良症是一种使人衰弱的x连锁遗传疾病，表现为儿童早期进行性肌肉无力，行动能力丧失，最终导致呼吸和心力衰竭，导致过早死亡。一名九岁男性患者，自六岁以来一直无法站立和行走，没有帮助。他之前被诊断为杜氏肌营养不良症，他的父母提供了相关的诊断文件。患者表现为下肢无力、食欲不振、排便不规律和易怒。从阿育吠陀医学的角度评估临床表现，并制定相应的治疗方案。治疗方案为期4个月，包括6个疗程，每次临床访问间隔15-20天。治疗方法包括主要的干预措施，如外部和内部Swedana， Basti和口服药物。同时，采用内部药物治疗和适当的饮食调整。内服药物包括仙花莲、苦参、苦参、假马齿苋和生姜等草药。此外，还使用了具有免疫调节、抗氧化和抗炎特性的草药。物理治疗继续作为整体管理策略的一部分。在第三次治疗之后，孩子表现出了在婴儿床的支撑下站立、抓握和扔石头的能力——这些能力在治疗之前是没有被观察到的。此外，在第一个月结束时，患者的食欲和排便习惯都有所改善。综合阿育吠陀疗法与物理疗法相结合，可以改善症状，如缓解便秘，用婴儿床支撑站立的能力，上肢肌肉张力的细微变化，以及儿童生活质量的整体提高。这项研究强调了阿育吠陀作为传统治疗的补充方法的潜力。

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引用次数: 0

Validation of an LCMS method for stability evaluations of piperine in Murchita utpalashatpala ghrita 用LCMS法评价辣椒碱的稳定性。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2026-01-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jaim.2025.101286

Ashutosh Gupta , Moumita Saha , Abhishek Ravindra Malandkar , Aditya Dev Rajora , Shivani Kunkalienkar , J. Dinesh Nayak , Sudheer Moorkoth

Background

Utpalashatphala ghrita (USG) is a traditional ayurvedic medicine containing piperine as its main chemical constituent responsible for the activity. Murchita is an ayurvedic process to detoxify and purify the lipids (ghee, oil). It involves heating ghee with specific ayurvedic ingredients for a specified duration and temperature. It is essential to understand the stability of piperine during and after the murchita process.

Objective

The objective of this study was to develop and validate an LCMS method to assess the stability of piperine after the murchita process.

Method

LCMS system with electrospray ionization and ion-trap as the analyser was used to estimate the piperine content. Analysis was carried out in the multiple reaction monitoring (MRM) mode. Chromatographic mobile phase composed of a mixture of 55 % formic acid (0.1 %) in Milli-Q water (pH 3) and 45 % methanol. The LC-MS method was validated as per ICH Q2 (R2) guidelines. Stability of ghrita was assessed at various stability conditions.

Result

The developed LCMS method was accurate, precise and linear over a range of 0.5–32 μg/mL. LOQ of the method was 125 ng/mL and the run time was 10 min. Utpalashatphala ghrita (USG) and Murchita- Utpalashatphala ghrita (M-USG) were prepared as specified under Bhaishajya Ratnavali. Our study revealed that the murchita process degraded piperine by 26 %. However, the stability of piperine was found to be better in the murchita ghrita (M -USG), compared to the unprocessed USG.

Conclusion

Study effectively demonstrated that the murchita process enhanced the long-term stability of piperine.

背景：Utpalashatphala ghrita （USG）是一种传统的印度草药，其主要化学成分是胡椒碱。Murchita是一种阿育吠陀方法，用于排毒和净化脂质（酥油，油）。它包括在特定的时间和温度下加热含有特定阿育吠陀成分的酥油。在默奇塔过程中和之后，了解胡椒碱的稳定性是至关重要的。目的：本研究的目的是建立和验证一种LCMS方法来评估摩奇塔工艺后胡椒碱的稳定性。方法：采用电喷雾电离和离子阱相结合的LCMS系统测定胡椒碱的含量。采用多反应监测（MRM）模式进行分析。色谱流动相由55%甲酸（0.1%）与ml - q水（pH 3）和45%甲醇的混合物组成。LC-MS方法按照ICH Q2 （R2）指南进行验证。在不同的稳定性条件下评价了ghrita的稳定性。结果：本方法在0.5 ~ 32 μg/mL范围内准确度高、精密度好、线性良好。该法的定量限为125 ng/mL，运行时间为10 min。Utpalashatphala ghrita （USG）和Murchita- Utpalashatphala ghrita （M-USG）是按照Bhaishajya Ratnavali的规定制备的。我们的研究表明，murchita工艺降低了26%的胡椒碱。然而，与未加工的USG相比，在murchita ghrita （M -USG）中发现胡椒碱的稳定性更好。结论：研究有效地证明了murchita工艺增强了胡椒碱的长期稳定性。

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引用次数: 0