Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Synthesis and characterization of Sajjikshara derived from two distinct sources: herbal and mineral","authors":"Piyush Krantikumar Gandhi ,&nbsp;Rajesh Kundlikrao Ingole ,&nbsp;Ganesh Nigade","doi":"10.1016/j.jaim.2025.101264","DOIUrl":"10.1016/j.jaim.2025.101264","url":null,"abstract":"<div><h3>Background</h3><div><em>Sajjikshara</em> is derived from both plant and mineral sources. It is important to note that the API does not specify standards for <em>Sajjikshara</em> obtained from herbal and Mineral sources. Therefore, a comparative physicochemical analysis is essential to determine its composition.</div></div><div><h3>Objectives</h3><div>This study was designed to compare <em>Sajjikshara</em> prepared from two distinct sources: herbal-mineral, in terms of pharmaceutics and analytical parameters.</div></div><div><h3>Material and methods</h3><div><em>Sajjikshara</em> was prepared using the ash of <em>Duaralabha Panchang</em> (the whole plant of <em>Fagonia cretica</em> Linn.) and <em>Sajjimitti</em> (a special type of soil) according to textual references from Rasa Tarangini and Rasajalanidhi. Both herbal and mineral <em>Sajjikshara</em> (<em>Sajjikshara</em>-H and M, respectively) were analysed using various physicochemical parameters, phytochemical parameters, and concentrations of sodium (Na), potassium (K), carbonate, hydroxide, sulfate, and nitrate groups, as well as microbial load, aflatoxin concentration, and heavy metals (arsenic, mercury, and lead). X-ray diffraction (XRD) analysis was conducted to identify the crystals, and Fourier transform Infra-Red (FTIR) spectroscopy was used to determine the functional groups present in both types of <em>Sajjikshara</em>.</div></div><div><h3>Results</h3><div>The pH of both <em>Sajjikshara</em> types is approximately the same, exhibiting an alkaline nature. <em>Sajjikshara</em>-M has a higher percentage of ash value, acid-insoluble ash, and concentrations of Na, K, and carbonate groups. The absence of heavy metals, microbial load, and aflatoxins in both <em>Sajjikshara</em> indicates careful preparation. FTIR and XRD analyses of both <em>Sajjikshara</em> types reveal the presence of carbonate crystals.</div></div><div><h3>Conclusion</h3><div><em>Sajjikshara</em> derived from minerals contains a higher percentage of sodium, carbonates, and is cost-effective.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101264"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Yoga and naturopathic intervention on cardiac autonomic functions in chronic kidney disease with coronary artery disease – A Case Series","authors":"Deepa Yoganathan ,&nbsp;Vimal Vadivel ,&nbsp;Vaishali Narayanan ,&nbsp;Maheshkumar Kuppusamy ,&nbsp;Meenakshi Venkatesan","doi":"10.1016/j.jaim.2025.101261","DOIUrl":"10.1016/j.jaim.2025.101261","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) and coronary artery disease (CAD) are significant global health challenges with high mortality rates. Conventional treatments often yield limited satisfaction, necessitating exploration of integrative therapeutic approaches. Four patients (3 males, 1 female; ages 39–56) with confirmed CKD (eGFR &lt;15 ml/min) and CAD were enrolled. Patients presented with symptoms including breathing difficulties, chest heaviness, and reduced cardiac function, and were unsatisfied with previous conventional treatments. Patients underwent a 15-day intense program combining yoga, acupuncture, hydrotherapy, manipulative therapy, and specialised naturopathic diet. Daily yoga sessions lasted 60–75 minutes and included specific <em>asanas</em>, breathing techniques and relaxation practices. Heart rate variability (HRV) analysis revealed significant improvements across multiple autonomic function markers, observed across all patients. Mean RR intervals increased, with case 3 rising from 582 ms to 675 ms. RMSSD improved from 22.5 ms to 46.9 ms in case 1, indicating enhanced parasympathetic activity. The Stress Index decreased across all cases, most notably in case 3 from 96.4 to 44.8. The LF/HF ratio approached more balanced levels, with case 3 moving from 2.633 to 0.995, suggesting improved autonomic regulation. The integrated yoga and naturopathic intervention demonstrated potential in improving cardiac autonomic functions in CKD and CAD patients. Results suggest these complementary approaches may offer a promising adjunct to conventional medical management by modulating autonomic nervous system activity.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101261"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of psoriatic arthritis with Dactylitis - A Case Report","authors":"Sinimol Thekkekkootumughath Peethambaran ,&nbsp;Sree Deepthi Girija Nalinakshan","doi":"10.1016/j.jaim.2025.101200","DOIUrl":"10.1016/j.jaim.2025.101200","url":null,"abstract":"<div><div>This case report is the description of dactylitis associated with Psoriatic arthritis (PsA) of a thirty-eight years old male, government employee. He presented with complaints of pain, swelling, stiffness and restriction of movements in fingers of upper limb, especially distal interphalangeal joints (IJP) for 1 month. Skin manifestations like silvery flaky scales, itching over the scalp region and mild pinkish discoloration on mid dorsum of right foot were also present. Diagnosis was made with the aid of CASPAR criteria, history taking and clinical examination. Only temporary relief was obtained from non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) he had taken for 2 weeks as suggested by conventional treatment. In Ayurvedic parlance, PsA resembles conditions like <em>Gambheera Vatrakta</em>, due to involvement of skin and deeper tissues like bones and joints and dactylitis may be considered as <em>Anguli sopha</em>. Internal medications with properties alleviating three doshas <em>(tridoshahara</em>)<em>,</em> skin diseases <em>(kushtahara),</em> vitiated <em>rakta dhatu (raktahara)</em>, which detoxifies blood <em>(raktaprasadana),</em> anodyne <em>(soolahara),</em> anti-inflammatory <em>(shothahara),</em> rejuvenating <em>(Rasayana)</em> were used. The assessment was done before and after the treatment by using the Psoriasis Area and Severity Index (PASI) score and European Alliance of Associations for Rheumatology's ‘The Psoriatic Arthritis Impact of Disease 12 (EULAR PsAID 12)’ questionnaire score. It was observed that symptoms were almost completely resolved with Ayurvedic management and changes in biochemical parameters were also noted. Prescribed Ayurvedic medications was found to be a good alternative therapy in managing dactylitis associated with PsA.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101200"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of Glycyrrhiza glabra homeopathic formulations in a rat model of lipopolysaccharide-induced inflammation","authors":"Bharti Gawai,&nbsp;Amol A. Tagalpallewar,&nbsp;Anil T. Pawar,&nbsp;Akshay M. Baheti","doi":"10.1016/j.jaim.2025.101267","DOIUrl":"10.1016/j.jaim.2025.101267","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation plays a crucial role in the pathogenesis of various chronic diseases. Alternative therapies, such as homeopathy, have gained attention for their potential in managing inflammatory conditions. <em>Glycyrrhiza glabra</em>, commonly known as licorice, is well-documented for its anti-inflammatory properties in herbal medicine. However, its efficacy in homeopathic formulations remains largely unexplored.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the anti-inflammatory potential of different homeopathic potencies of <em>Glycyrrhiza glabra</em> against lipopolysaccharide (LPS)-induced inflammation in rats.</div></div><div><h3>Methods</h3><div>Male Wistar rats were divided into seven groups: normal control, LPS-induced inflammation control, dexamethasone-treated, <em>Glycyrrhiza glabra</em> homeopathic mother tincture (GHMT)-treated, and groups treated with <em>Glycyrrhiza glabra</em> homeopathic potency (G6CH, G30CH, G200CH). Anti-inflammatory effects of GHMT, G6CH, G30CH, and G200CH were evaluated against LPS-induced inflammation by measuring paw volume, serum pro-inflammatory cytokine levels [tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)], levels of oxidative stress biomarkers (superoxide dismutase, glutathione, and catalase) in paw tissues, and histopathological changes in inflamed paw tissues.</div></div><div><h3>Results</h3><div>The results demonstrated a significant reduction in paw volume in GHMT and G200CH-treated groups (p&lt;0.0001) as compared to the inflammation control group. Additionally, the levels of serum TNF-α and IL-6 were significantly lowered (p&lt;0.0001), and oxidative stress biomarkers showed significant improvement (p&lt;0.0001) in GHMT and G200CH-treated groups. Histopathological examination further confirmed the reversal of inflammation-induced tissue changes by <em>G. glabra</em> homeopathic formulations, indicating its anti-inflammatory activity.</div></div><div><h3>Conclusion</h3><div>These findings provide scientific evidence supporting the anti-inflammatory potential of homeopathic formulations of <em>Glycyrrhiza glabra</em>, particularly GHMT and G200CH. The study suggests that these homeopathic potencies could serve as promising alternative anti-inflammatory agents, warranting further research to elucidate the underlying molecular mechanisms.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101267"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo and in silico toxicity studies of hydroalcoholic extract of Vetiveria zizanioides roots","authors":"Pranali B. Yeram,&nbsp;Amisha Vora,&nbsp;Yogesh A. Kulkarni","doi":"10.1016/j.jaim.2025.101256","DOIUrl":"10.1016/j.jaim.2025.101256","url":null,"abstract":"<div><h3>Background</h3><div><em>Vetiveria zizanioides</em> (L.) is a traditional Indian medicinal plant belonging to the family Poaceae. Hydroalcoholic extract of <em>Vetiveria zizanioides</em> has been studied for its various pharmacological effects, but a systematic scientific study on its safety has not been done.</div></div><div><h3>Objective</h3><div>To study the toxic effects of single and repeated doses of hydroalcoholic extract of <em>Vetiveria zizanioides</em> root, and to establish the toxicity profile of hydroalcoholic extract using <em>in silico</em> toxicity prediction tools.</div></div><div><h3>Methods</h3><div>Acute and repeated dose toxicity studies were conducted following OECD guidelines 423 and 407, respectively. The acute toxicity study was carried out on female Sprague Dawley rats at 2000 and 5000 mg/kg doses, with effects monitored for 14 days. A repeated dose toxicity study was performed through daily dosing of the hydroalcoholic extract (ethanol: water, 1:1 v/v) of <em>Vetiveria zizanioides</em> extract for 28 days at doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg. At the end of the study, hematological parameters, biochemical parameters, kidney function, and histopathology were evaluated in all animals. Additionally, <em>In silico</em> toxicity prediction of the bioactive present in <em>Vetiveria zizanioides</em> root extract was performed using ProTox-II. Phytoconstituents of <em>Vetiveria zizanioides</em> roots were identified using GC-MS analysis.</div></div><div><h3>Results</h3><div>Single dose administration of <em>Vetiveria zizanioides</em> extract at 5000 mg/kg showed no toxicity or morbidity. Similarly, repeated doses of extract over 28 days did not significantly impact hematological and biochemical parameters. However, a significant increase in ALT (P &lt; 0.05) was noted at the highest dose (1000 mg/kg) of the extract. Histopathological examinations of the liver at this dose revealed mild changes in hepatocytes compared to the control animals. The toxicity prediction revealed that all identified compounds of <em>Vetiveria zizanioides</em> hydroalcoholic extract were free from cytotoxicity and mutagenicity. More than 50 percent of the compounds were found to be class 5 (2000 &lt; LD50 ≤ 5000). However, few compounds were found to be hepatotoxic at high doses.</div></div><div><h3>Conclusion</h3><div><em>Vetiveria zizanioides</em> extract may generally be safe, but long-term use at 1000 mg/kg in rats could pose a concern for liver toxicity. The results of the study indicate that <em>Vetiveria zizanioides</em> is safe for use up to 500 mg/kg in 28-day repeated dose toxicity study.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101256"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the pharmacokinetic interactions between cisplatin and Triphala through in-vitro, in-vivo, and in-silico approaches – A pilot study to bridge modern medicine with Ayurveda","authors":"T.K. Girija Kumari ,&nbsp;Kamatchi Sundara Saravanan ,&nbsp;Lakshmi M. Sundar ,&nbsp;Gouri Nair ,&nbsp;G.N.S. Hemasree ,&nbsp;Ganesan Rajalekshmi Saraswathy","doi":"10.1016/j.jaim.2025.101253","DOIUrl":"10.1016/j.jaim.2025.101253","url":null,"abstract":"<div><h3>Background</h3><div>Herbal drugs are often used alongside conventional cancer therapies to mitigate the adverse effects and enhance therapeutic efficacy. Triphala, a traditional herbal formulation used in Ayurveda, is known for its anticancer and CYP2E1 inhibitory properties. Cisplatin, although highly effective in cancer treatment, is known to cause significant hepatotoxicity and nephrotoxicity which are mediated by toxic metabolites formed through CYP2E1 metabolism.</div></div><div><h3>Objective</h3><div>The objective of this study is to explore the pharmacokinetic drug interactions between Triphala and cisplatin.</div></div><div><h3>Methods</h3><div>At the outset, the pharmacokinetic interactions between Triphala and cisplatin were confirmed by <em>in-vitro</em> experiments using HepG2 and 786-0 cell lines based on Reactive Oxygen Species (ROS) generation and cell viability assay, and <em>in-vivo</em> study using Sprague Dawley rats based on serum cisplatin concentration. Later, the literature derived phytoconstituents were subjected to <em>in</em><em>-</em><em>silico</em> studies to investigate their molecular interactions with the metabolizing enzyme CYP2E1.</div></div><div><h3>Results</h3><div><em>In-vitro</em> studies revealed a reduction in ROS generation and enhanced cell viability, indicating that the metabolism of cisplatin is hindered by Triphala, which was attributed to its CYP2E1 inhibitory potential. <em>In-vivo</em> studies showed a marginal increase in cisplatin concentrations in rat serum that received the combination of Triphala and cisplatin, supporting the <em>in-vitro</em> findings. <em>In</em><em>-</em><em>silico</em> studies revealed that Triphala constituents, especially gallic acid and 3,5-dihydroxy-4-methoxybenzoic acid, stably bind and potentially inhibit CYP2E1 via key interactions with THR303.</div></div><div><h3>Conclusion</h3><div>The results suggest that Triphala may interact with cisplatin by inhibiting the CYP2E1 enzyme, potentially affecting the metabolism and toxicity of cisplatin. These findings highlight the need for further research to evaluate the clinical implications of using Triphala alongside cisplatin-based cancer therapies.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101253"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of yoga regimen on the lung capacity of defence personnel deployed at high altitude area","authors":"Lakhvinder Singh,&nbsp;Rithika Keshav,&nbsp;Mangesh Pandey,&nbsp;Natesh Babu","doi":"10.1016/j.jaim.2025.101223","DOIUrl":"10.1016/j.jaim.2025.101223","url":null,"abstract":"<div><h3>Background</h3><div>High-altitude survival is difficult due to low oxygen levels. Good lung function and oxygen saturation are essential for optimum health. India's northern borders, characterized by mountainous terrain, remain vulnerable to infiltrators and enemies. Defence personnel assigned to these areas often face health challenges due to sudden shifts from low to high altitudes. Therefore, proper acclimatization is vital. Studies suggest yoga improves lung function and oxygen saturation, aiding adaptation.</div></div><div><h3>Objective</h3><div>This study explores whether the regular practice of yoga can help defence personnel stay prepared for high-altitude deployment by examining lung function, oxygen saturation, and heart rate.</div></div><div><h3>Method</h3><div>The present study, using a single-group pre-post design, evaluated the effectiveness of a yogic training program consisting of 50-min sessions administered over 20 consecutive days to twenty-two defence personnel deployed in a high-altitude area. The assessments for various Lung Function, Oxygen Saturation and Heart Rate were conducted before and after the intervention.</div></div><div><h3>Results</h3><div>The results demonstrated significant improvement in lung function and SPO₂. Statistically significant improvements were observed in expiratory flow rate (<em>p</em> &lt; 0.001), bhramari time (<em>p</em> &lt; 0.001), breath-holding time (<em>p</em> &lt; 0.001), oxygen saturation (<em>p</em> &lt; 0.001), and heart rate (<em>p</em> = 0.033).</div></div><div><h3>Conclusions</h3><div>Yogic practices—especially postures with breath awareness, breathing techniques, and mindfulness—significantly enhance lung function, including breath-holding and oxygen saturation. Integrating yoga into defence personnel routines may boost tolerance to hypoxia and improve operational performance. Further research is needed to assess yoga's impact on physical and mental fitness in high-altitude conditions.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101223"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo effects of IVT-15 - A traditional knowledge-inspired formulation for the management of rheumatoid arthritis","authors":"Dnyaneshwar U. Bawankule ,&nbsp;Amit Kaushik ,&nbsp;Mridula Sahu ,&nbsp;Dewasya P. Singh ,&nbsp;Aashcharya U. Mishra ,&nbsp;Vineet Babu ,&nbsp;Princi Gupta ,&nbsp;Ashutosh K. Shukla ,&nbsp;Velusamy Sundaresan ,&nbsp;Ritu Trivedi ,&nbsp;Karuna Shanker ,&nbsp;Debabrata Chanda ,&nbsp;Anirban Pal ,&nbsp;Mahendra P. Darokar ,&nbsp;Narayan P. Yadav ,&nbsp;Atul Gupta ,&nbsp;Daya N. Mani ,&nbsp;Suman P.S. Khanuja","doi":"10.1016/j.jaim.2025.101216","DOIUrl":"10.1016/j.jaim.2025.101216","url":null,"abstract":"<div><h3>Background</h3><div><u>-</u> <em>Cyperus scariosus</em>, <em>Zingiber officinale</em>, and <em>Piper longum</em> are known and used in <em>Ayurveda</em> to manage rheumatoid arthritis (RA). Due to their intrinsic properties, these plants fight diseases from different aspects. Combination of the three is suspected to provide all-around approach to manage RA and related disorders.</div></div><div><h3>Objective</h3><div><u>-</u> The study aims to scientifically validate the efficacy of IVT-15 (combination of <em>C. scariosus</em>, <em>Z. officinale</em>, and <em>P. longum</em>) against RA and related disorders.</div></div><div><h3>Materials &amp; methods</h3><div>IVT-15 was prepared by mixing aqueous extracts of the three plants in 1:1:1 ratio and analysed using high performance liquid chromatography (HPLC) for authenticating plant materials. IVT-15, a chemically defined formulation was further scientifically validated for safety and efficacy. Acute and subacute toxicity studies were performed on Swiss albino mice and efficacy was studied on standard animal models.</div></div><div><h3>Results</h3><div>Chemical profiling revealed high presence of 6-gingerol, α-cyperone, and piperine, and toxicity studies proved IVT-15 to be safe up to 2000 mg/kg body weight single dose acute oral toxicity study. IVT-15 revealed its <em>in</em> <em>vivo</em> anti-arthritic efficacy by reducing arthritis score and index significantly against collagen-induced arthritis. Reduction of tumor necrosis factor (TNF)-α, interleukin-1β (IL-1β), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-induced inflammation confirmed anti-inflammatory potential of IVT-15. Further in vivo testing indicated that IVT-15 has potential analgesic and immunomodulatory properties.</div></div><div><h3>Conclusion</h3><div>This study proves that IVT-15 can be used as alternative medicine for managing RA. Future clinical studies on IVT-15 will help in realizing its full healthcare benefits against arthritis.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101216"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking silos in healthcare: A futuristic vision for Viksit Bharat","authors":"Bhushan Patwardhan ,&nbsp;Gururaj Mutalik ,&nbsp;Girish Tillu","doi":"10.1016/j.jaim.2025.101288","DOIUrl":"10.1016/j.jaim.2025.101288","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101288"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and effect of Naga Bhasma on hypoglycemic, antihyperglycemic, and antidiabetic activities in Charles Foster diabetic rats","authors":"Pravin Tate ,&nbsp;B.J. Patgiri ,&nbsp;P.K. Prajapati ,&nbsp;B. Ravishankar","doi":"10.1016/j.jaim.2025.101226","DOIUrl":"10.1016/j.jaim.2025.101226","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes, typically characterized by hyperglycaemia, is a leading cause of morbidity and mortality. Over 800 million adults were estimated to have diabetes in 2022. <em>Ayurveda</em> texts emphasized on the antidiabetic potential of <em>Naga Bhasma</em> (NB) (a lead based formulation). <em>Naga Bhasma</em> is used in many classical antidiabetic formulations such as <em>Vasantkusumakara Rasa</em>.</div></div><div><h3>Objectives</h3><div>Present study was planned to evaluate hypoglycemic, antihyperglycemic, and antidiabetic activities of <em>Naga Bhasma</em> in euglycemic, sucrose loaded hyperglycemic and streptozotocin induced diabetic Charles Foster albino rats.</div></div><div><h3>Material and methods</h3><div>NB was prepared following classical texts of Ayurveda. Charles Foster albino rats were used for antidiabetic study. The study was divided into: hypoglycaemic, antihyperglycemic, and antidiabetic parts. Hypoglycaemic study was aimed to assess glucose lowering activity in normal rats. Antihyperglycemic study was carried out to assess the effect of test drug on blood sugar elevation observed after administration of sucrose (40 g/kg orally). For antidiabetic study, streptozotocin was injected intraperitoneally (40 mg/kg) to induce diabetes. Vehicles were administered on 3rd day of streptozotocin injection, after confirmation of diabetes. Blood sugar was checked before and on 5th day after vehicle administration. The data was analysed by unpaired ‘t’ test.</div></div><div><h3>Results</h3><div>Hypoglycaemic study did not show any significant effect on blood glucose in NB group. In Antihyperglycemic study, NB administered group showed only statistically non-significant increase in blood sugar level at 4th and 8th hour indicating presence of anti-hyperglycemic activity. In antidiabetic study, in control group, a statistically significant (48.90 %) elevation of blood sugar level was observed while in NB administered group highly significant (69.58 %) decrease was observed in comparison to initial values.</div></div><div><h3>Conclusion</h3><div>The study shows that NB has moderate anti-hyperglycaemic and good anti-diabetic activity; and it does not lower the blood glucose below the normal levels.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101226"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}