Pub Date : 2026-01-01Epub Date: 2026-02-18DOI: 10.1016/j.jaim.2026.101328
{"title":"The Delhi Declaration on Traditional Medicine: Outcome of the Second WHO Global Summit on Traditional Medicine (2025)","authors":"","doi":"10.1016/j.jaim.2026.101328","DOIUrl":"10.1016/j.jaim.2026.101328","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101328"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-12-10DOI: 10.1016/j.jaim.2025.101181
Somit Kumar , Kavitha Singh , Santhi Krishna A S
Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time. The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.
{"title":"Efficacy of standalone personalized Ayurveda management in moderating functional index, inflammatory markers & radiological progression in Ankylosing Spondylitis with 12 years follow up – A case report","authors":"Somit Kumar , Kavitha Singh , Santhi Krishna A S","doi":"10.1016/j.jaim.2025.101181","DOIUrl":"10.1016/j.jaim.2025.101181","url":null,"abstract":"<div><div>Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time<strong>.</strong> The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101181"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duchenne Muscular Dystrophy (DMD; OMIM #310200) and Becker Muscular Dystrophy (BMD; OMIM #300376) are rare and severe genetic conditions. These X-linked recessive Muscular Dystrophies (MDs) stem from variants in the DMD gene (OMIM #300377), encoding the dystrophin protein (Uniprot #P11532). The Prakriti concept, adjudged in Ayurveda, epitomizes an individual's nature-nurture and has gained significance in healthcare with the emerging field of Ayurgenomics.
Objective
The present research thoroughly analyses demographic, clinical, genetic, and Prakriti profiles in the D/BMD patients of Gujarat, India by integrating ancient wisdom with modern paradigms.
Materials and methods
This observational study included 120 male participants whose demographic and clinical data were assessed. The concentration of total CPK was measured. Genetic analysis methods, viz. MPCR, MLPA, and NGS were applied to identify variants. Prakriti profiles of all participants were assessed using AyuSoft.
Results
The demographic and clinical aspects of the study highlight the heterogeneity in disease severity and progression, with 15.83% of familial cases. The difference in CPK levels between DMD (12,445.15 U/L) and BMD (8,095 U/L) underscores the usual gradient in severity seen in these two types. Comprehensive genetic analysis revealed 87.5% DMD and 12.5% BMD, where 90% were identified as deletions, 4.17% duplications, and 5.83% point variants. In the cohort, 84.96% of variants were out-of-frame and 15.04% in-frame. Variant events were predominantly in distal regions (78.33%) and involved the central hotspot domain (65.83%). Among the detected deletions, 45-52 deletions exhibited dominantly in DMD participants with heightened frequency for exon 50. The study uniquely integrates Ayurvedic Prakriti profiles into the analysis, contributing additional insight into the disease framework. Based on seven distinct Prakritis, three profiles emerged prominently within our study. These are KaphapradhaanaPittaanubandhi (KP), KaphapradhaanaVaataanubandhi (KV), and VaatapradhaanaKaphaanubandhi (VK). The distribution of Prakriti differed between DMD and BMD participants. In both groups, 46.67% had KP Prakriti, whereas DMD had 40.95% KV and 12.38% VK. Conversely, 53.33% of BMD participants had KV Prakriti, and VK Prakriti was absent.
Conclusion
The varying distribution of profiles introduces possibilities for Prakriti-based stratification of D/BMD. The multiple Factor Analysis (MFA) highlights the importance of age and Severity in the analysis. Such integrative Ayurgenomics holds promise for a deeper comprehension of genetic conditions and for paving the way for the development of innovative, real-time, and personalized management.
{"title":"Prakriti and genetic profiling in Duchenne/Becker muscular dystrophy: An Ayurgenomic appraisal towards personalized care","authors":"Pooja Trivedi , Dhruv Prajapati , Krishnakumari Patel , Khushi Dhamecha , Gaurang Sindhav","doi":"10.1016/j.jaim.2025.101241","DOIUrl":"10.1016/j.jaim.2025.101241","url":null,"abstract":"<div><h3>Background</h3><div>Duchenne Muscular Dystrophy (DMD; OMIM #310200) and Becker Muscular Dystrophy (BMD; OMIM #300376) are rare and severe genetic conditions. These X-linked recessive Muscular Dystrophies (MDs) stem from variants in the DMD gene (OMIM #300377), encoding the dystrophin protein (Uniprot #P11532). The Prakriti concept, adjudged in Ayurveda, epitomizes an individual's nature-nurture and has gained significance in healthcare with the emerging field of Ayurgenomics.</div></div><div><h3>Objective</h3><div>The present research thoroughly analyses demographic, clinical, genetic, and Prakriti profiles in the D/BMD patients of Gujarat, India by integrating ancient wisdom with modern paradigms.</div></div><div><h3>Materials and methods</h3><div>This observational study included 120 male participants whose demographic and clinical data were assessed. The concentration of total CPK was measured. Genetic analysis methods, <em>viz.</em> MPCR, MLPA, and NGS were applied to identify variants. Prakriti profiles of all participants were assessed using AyuSoft.</div></div><div><h3>Results</h3><div>The demographic and clinical aspects of the study highlight the heterogeneity in disease severity and progression, with 15.83% of familial cases. The difference in CPK levels between DMD (12,445.15 U/L) and BMD (8,095 U/L) underscores the usual gradient in severity seen in these two types. Comprehensive genetic analysis revealed 87.5% DMD and 12.5% BMD, where 90% were identified as deletions, 4.17% duplications, and 5.83% point variants. In the cohort, 84.96% of variants were out-of-frame and 15.04% in-frame. Variant events were predominantly in distal regions (78.33%) and involved the central hotspot domain (65.83%). Among the detected deletions, 45-52 deletions exhibited dominantly in DMD participants with heightened frequency for exon 50. The study uniquely integrates Ayurvedic Prakriti profiles into the analysis, contributing additional insight into the disease framework. Based on seven distinct Prakritis, three profiles emerged prominently within our study. These are <em>Kaphapradhaana</em> <em>Pittaanubandhi</em> (KP), <em>Kaphapradhaana</em> <em>Vaataanubandhi</em> (KV), and <em>Vaatapradhaana</em> <em>Kaphaanubandhi</em> (VK). The distribution of Prakriti differed between DMD and BMD participants. In both groups, 46.67% had KP Prakriti, whereas DMD had 40.95% KV and 12.38% VK. Conversely, 53.33% of BMD participants had KV Prakriti, and VK Prakriti was absent.</div></div><div><h3>Conclusion</h3><div>The varying distribution of profiles introduces possibilities for Prakriti-based stratification of D/BMD. The multiple Factor Analysis (MFA) highlights the importance of age and Severity in the analysis. Such integrative Ayurgenomics holds promise for a deeper comprehension of genetic conditions and for paving the way for the development of innovative, real-time, and personalized management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101241"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-01-30DOI: 10.1016/j.jaim.2025.101266
Rabia Malik , Mohd Aleemuddin Quamri , Galib R , Muzafar Din Ahmad Bhat , Mehjabeen Fatimah
Materiovigilance is the practice of monitoring and ensuring the safety of medical devices by identifying, assessing, and mitigating risks associated with their use. While this concept is well-established in modern medicine, its foundational principles can also be traced back to Unani literature, which emphasizes the safe and effective use of tools and instruments in traditional therapies. The integration of materiovigilance into the Unani system of medicine is a significant step towards enhancing patient safety and ensuring the efficacy of traditional healthcare practices. Unani medicine, known for its holistic approach, incorporates various therapeutic regimens such as Ḥijama(Cupping Therapy), Fasd(Venesection), Taliq al-‘Alaq(Leech Therapy), etc., many of which involve the use of medical devices and instruments. These devices, ranging from simple tools to complex instruments, pose varying levels of risk to patients. In this review, the concept of materiovigilance, its relevance to the Unani system, and the importance of its integration to ensure patient safety and improve treatment outcomes have been examined. It categorizes Unani therapeutic devices based on their risk levels—low, moderate, and high—underscoring the need for tailored monitoring and safety measures for each category. The paper also discusses the challenges and opportunities in implementing materiovigilance within Unani practices. The adoption of such measures is crucial for safeguarding patient health, maintaining the quality of traditional therapies, and aligning with international safety and regulatory standards. This integration not only supports the sustainable development of Unani medicine but also strengthens its role in the broader healthcare landscape.
{"title":"Integration of materiovigilance in Unani medicine: A step towards patient safety","authors":"Rabia Malik , Mohd Aleemuddin Quamri , Galib R , Muzafar Din Ahmad Bhat , Mehjabeen Fatimah","doi":"10.1016/j.jaim.2025.101266","DOIUrl":"10.1016/j.jaim.2025.101266","url":null,"abstract":"<div><div>Materiovigilance is the practice of monitoring and ensuring the safety of medical devices by identifying, assessing, and mitigating risks associated with their use. While this concept is well-established in modern medicine, its foundational principles can also be traced back to Unani literature, which emphasizes the safe and effective use of tools and instruments in traditional therapies. The integration of materiovigilance into the Unani system of medicine is a significant step towards enhancing patient safety and ensuring the efficacy of traditional healthcare practices. Unani medicine, known for its holistic approach, incorporates various therapeutic regimens such as <em>Ḥijama</em>(Cupping Therapy), <em>Fasd</em>(Venesection), <em>Taliq al-‘Alaq</em>(Leech Therapy), etc., many of which involve the use of medical devices and instruments. These devices, ranging from simple tools to complex instruments, pose varying levels of risk to patients. In this review, the concept of materiovigilance, its relevance to the Unani system, and the importance of its integration to ensure patient safety and improve treatment outcomes have been examined. It categorizes Unani therapeutic devices based on their risk levels—low, moderate, and high—underscoring the need for tailored monitoring and safety measures for each category. The paper also discusses the challenges and opportunities in implementing materiovigilance within Unani practices. The adoption of such measures is crucial for safeguarding patient health, maintaining the quality of traditional therapies, and aligning with international safety and regulatory standards. This integration not only supports the sustainable development of Unani medicine but also strengthens its role in the broader healthcare landscape.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101266"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2026-02-16DOI: 10.1016/j.jaim.2025.101293
Divyansh Pandey , Arnav Bhavsar , Alok Bajpai
Social Media Addiction (SMA), a pervasive behavior disorder of the modern digital age, particularly in youth, is characterized by compulsive internet use and disrupted cognitive control. This narrative review integrates evidence from modern neuroscience and ancient Indian mind-body knowledge systems, namely Ayurveda, Yoga, and spiritual scripture on the basis of the Bhagavad Gita, Katha Upanishad, Charak Samhita, and Yoga Sutras.
Databases such as PubMed, Google Scholar, Scopus, and JSTOR were searched using keywords such as “social media addiction,” “Neurobiological mechanisms,” “Ayurveda,” “Indian Knowledge Systems,” and “Yoga and mindfulness,”. PRISMA-based screening of the studies was conducted for the period 1994–2024. Included peer-reviewed articles were thematically categorized into neuroscience-based mechanisms of SMA, mind-body interventions (Yoga, mindfulness), and Ayurvedic models (Pradnyaparadh, Triguna, Satvavajaya Chikitsa, and Medhya Rasayana).
This transdisciplinary overview illustrates the potential of integrative approaches that align neuroplastic techniques with culture-informed models of therapeutics. The aim is to comprehend how neurobiological processes like compromised executive function, reward sensitivity, and brain development intersect with ancient Indian mind-body balance systems, moral living, and mental self-regulation. By considering empirical neuroscience as well as established frameworks in Indian medicine and philosophy, it suggests an improved, holistic approach to understanding and treating social media addiction.
{"title":"Understanding social media addiction through Ayurveda, Yoga, and Neuroscience: A narrative review anchored in Indian Knowledge Systems","authors":"Divyansh Pandey , Arnav Bhavsar , Alok Bajpai","doi":"10.1016/j.jaim.2025.101293","DOIUrl":"10.1016/j.jaim.2025.101293","url":null,"abstract":"<div><div>Social Media Addiction (SMA), a pervasive behavior disorder of the modern digital age, particularly in youth, is characterized by compulsive internet use and disrupted cognitive control. This narrative review integrates evidence from modern neuroscience and ancient Indian mind-body knowledge systems, namely Ayurveda, Yoga, and spiritual scripture on the basis of the Bhagavad Gita, Katha Upanishad, Charak Samhita, and Yoga Sutras.</div><div>Databases such as PubMed, Google Scholar, Scopus, and JSTOR were searched using keywords such as “social media addiction,” “Neurobiological mechanisms,” “Ayurveda,” “Indian Knowledge Systems,” and “Yoga and mindfulness,”. PRISMA-based screening of the studies was conducted for the period 1994–2024. Included peer-reviewed articles were thematically categorized into neuroscience-based mechanisms of SMA, mind-body interventions (Yoga, mindfulness), and Ayurvedic models (<em>Pradnyaparadh</em>, <em>Triguna</em>, <em>Satvavajaya Chikitsa</em>, and <em>Medhya Rasayana</em>).</div><div>This transdisciplinary overview illustrates the potential of integrative approaches that align neuroplastic techniques with culture-informed models of therapeutics. The aim is to comprehend how neurobiological processes like compromised executive function, reward sensitivity, and brain development intersect with ancient Indian mind-body balance systems, moral living, and mental self-regulation. By considering empirical neuroscience as well as established frameworks in Indian medicine and philosophy, it suggests an improved, holistic approach to understanding and treating social media addiction.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101293"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.jaim.2025.101151
Bhushan Patwardhan
{"title":"","authors":"Bhushan Patwardhan","doi":"10.1016/j.jaim.2025.101151","DOIUrl":"10.1016/j.jaim.2025.101151","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101151"},"PeriodicalIF":1.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101224
Anjali Singh , Sanjoy Majhi , Arnab Das
Background
Suryanamaskar (SN) is popular amongst recent yoga practitioners for its health benefits and fitness promises. Most previous studies have focused on the long-term pre-post effects of SN intervention on health and fitness. However, a notable gap exists regarding the immediate response of practicing SN on cardiorespiratory and neuro-cognitive functions, especially in the female population.
Objectives
This study aimed to find the immediate effect of SN practice on cardiorespiratory functions and neuro-cognitive performance in healthy adult females.
Material and methods
A total of 21 healthy females (aged: 18–25 years) were selected in this Quasi pre-post experimental study, guided by the CONSORT tool. Cardiorespiratory, heart rate (HR) variability, and cognitive parameters were assessed before and immediately after 45 minutes of SN session using a metabolic gas analyzer, HR sensor, and psychometric tests, respectively. Paired t-test was performed to find the difference between the pre- and post-SN responses.
Results
A significant increase in average volume of oxygen consumption (VO2) (11.4 %; p < 0.01), minute ventilation (VE) (15.9 %; p < 0.001), respiratory frequency (Rf) (6.2 %; p < 0.01), respiratory quotient (RQ) (4.6 %; p < 0.01), and METS (12.4 %; p < 0.001) were observed immediately after SN session. No significant changes in blood pressure was observed. LF power (23.7 %; p < 0.01) and LF/HF ratio (79.9 %; p < 0.05) showed a significant increase along with a decrease in pNN50 % (16.9 %; p < 0.05) and HF power (16.4 %; p < 0.01) at post-SN. A significant improvement (p < 0.01) in Stroop congruent (14.78 %) and incongruent (13.7 %) reaction times was also observed immediately after the SN session.
Conclusion
These findings collectively indicate that a single session of SN effectively enhanced both cardiorespiratory and cognitive functions, which can be used to improve cardiometabolic health and to train the autonomic nervous system in females.
suryanamaskar （SN）因其健康益处和健身承诺在最近的瑜伽练习者中很受欢迎。以往的研究大多集中在SN干预对健康和健身的长期前后影响上。然而，关于SN练习对心肺和神经认知功能的即时反应，特别是在女性人群中，存在明显的差距。目的探讨瑜伽练习对健康成年女性心肺功能和神经认知功能的直接影响。材料与方法采用CONSORT工具进行准实验前后研究，选取年龄在18-25岁的健康女性21例。分别使用代谢气体分析仪、心率传感器和心理测量测试评估心肺、心率（HR）变异性和认知参数。配对t检验发现sn前后反应的差异。结果SN治疗后，平均耗氧量（VO2） （11.4%; p < 0.01）、分钟通气量（VE） （15.9%; p < 0.001）、呼吸频率（Rf） （6.2%; p < 0.01）、呼吸商（RQ） （4.6%; p < 0.01）和METS （12.4%; p < 0.001）均显著升高。血压未见明显变化。sn后低频段功率（23.7%;p < 0.01）和低频段/高频比（79.9%;p < 0.05）显著升高，pNN50 % （16.9%; p < 0.05）和高频功率（16.4%;p < 0.01）显著降低。在Stroop一致（14.78%）和不一致（13.7%）的反应时间上也有显著改善（p < 0.01）。结论单次SN可有效增强女性的心肺功能和认知功能，可用于改善女性心脏代谢健康和训练自主神经系统。
{"title":"Immediate effect of Suryanamaskar on cardiorespiratory functions and cognitive performance: A quasi-experimental study on young adult females","authors":"Anjali Singh , Sanjoy Majhi , Arnab Das","doi":"10.1016/j.jaim.2025.101224","DOIUrl":"10.1016/j.jaim.2025.101224","url":null,"abstract":"<div><h3>Background</h3><div>Suryanamaskar (SN) is popular amongst recent yoga practitioners for its health benefits and fitness promises. Most previous studies have focused on the long-term pre-post effects of SN intervention on health and fitness. However, a notable gap exists regarding the immediate response of practicing SN on cardiorespiratory and neuro-cognitive functions, especially in the female population.</div></div><div><h3>Objectives</h3><div>This study aimed to find the immediate effect of SN practice on cardiorespiratory functions and neuro-cognitive performance in healthy adult females.</div></div><div><h3>Material and methods</h3><div>A total of 21 healthy females (aged: 18–25 years) were selected in this Quasi pre-post experimental study, guided by the CONSORT tool. Cardiorespiratory, heart rate (HR) variability, and cognitive parameters were assessed before and immediately after 45 minutes of SN session using a metabolic gas analyzer, HR sensor, and psychometric tests, respectively. Paired <em>t</em>-test was performed to find the difference between the pre- and post-SN responses.</div></div><div><h3>Results</h3><div>A significant increase in average volume of oxygen consumption (VO<sub>2</sub>) (11.4 %; p < 0.01), minute ventilation (VE) (15.9 %; p < 0.001), respiratory frequency (Rf) (6.2 %; p < 0.01), respiratory quotient (RQ) (4.6 %; p < 0.01), and METS (12.4 %; p < 0.001) were observed immediately after SN session. No significant changes in blood pressure was observed. LF power (23.7 %; p < 0.01) and LF/HF ratio (79.9 %; p < 0.05) showed a significant increase along with a decrease in pNN50 % (16.9 %; p < 0.05) and HF power (16.4 %; p < 0.01) at post-SN. A significant improvement (p < 0.01) in Stroop congruent (14.78 %) and incongruent (13.7 %) reaction times was also observed immediately after the SN session.</div></div><div><h3>Conclusion</h3><div>These findings collectively indicate that a single session of SN effectively enhanced both cardiorespiratory and cognitive functions, which can be used to improve cardiometabolic health and to train the autonomic nervous system in females.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101224"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-alcoholic Fatty Liver Disease (NAFLD) involves excessive fat build-up in the liver unrelated to alcohol use. This study aimed to evaluate the clinical efficacy and safety of Liv-Pro capsules, a formulation combining Osbeckia octandra and Aloe vera, in managing NAFLD. This is the first report of the clinical trial using this combination against NAFLD.
Methods
A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 NAFLD patients from February 1, 2021 to March 31, 2023. Participants received either Liv-Pro or a placebo (two capsules once a day) for two months. Medical assessments at baseline, one month, and two months included liver function tests (ALT and AST), abdominal ultrasound scan, serum creatinine analysis, and lipid profile assessment. All patients were advised on lifestyle modifications.
Results
Liv-Pro significantly reduced ALT levels after one month (p = 0.049) and two months (p = 0.048) compared to baseline. AST levels also decreased significantly in the first (p = 0.047) and second months (p = 0.046), showing a consistent decline. Liv-Pro reduced total cholesterol, triglycerides, and Low-density lipoprotein (LDL) levels significantly after one and two months (p < 0.05) compared to baseline measurements. Abdominal ultrasound scans showed a significant decrease in hepatic fat content after two months (p = 0.020). Serum creatinine levels remained stable throughout the treatment period.
Conclusion
Liv-Pro was well-tolerated with no reported side effects, suggesting its potential as a safe and effective therapeutic option for NAFLD. Continuous administration of Liv-Pro is recommended for sustained efficacy.
{"title":"A randomised double blind placebo-controlled clinical trial to evaluate the effects of Liv-Pro- a food supplement for Non-Alcoholic Fatty Liver Disease","authors":"Anchala Ishani Kuruppu , Uditha Prabhath Liyanage , Aruni Chamika , Priyani Asoka Paranagama , Lankani Hettigoda","doi":"10.1016/j.jaim.2025.101196","DOIUrl":"10.1016/j.jaim.2025.101196","url":null,"abstract":"<div><h3>Background</h3><div>Non-alcoholic Fatty Liver Disease (NAFLD) involves excessive fat build-up in the liver unrelated to alcohol use. This study aimed to evaluate the clinical efficacy and safety of Liv-Pro capsules, a formulation combining <em>Osbeckia octandra</em> and <em>Aloe vera</em>, in managing NAFLD. This is the first report of the clinical trial using this combination against NAFLD.</div></div><div><h3>Methods</h3><div>A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 NAFLD patients from February 1, 2021 to March 31, 2023. Participants received either Liv-Pro or a placebo (two capsules once a day) for two months. Medical assessments at baseline, one month, and two months included liver function tests (ALT and AST), abdominal ultrasound scan, serum creatinine analysis, and lipid profile assessment. All patients were advised on lifestyle modifications.</div></div><div><h3>Results</h3><div>Liv-Pro significantly reduced ALT levels after one month (p = 0.049) and two months (p = 0.048) compared to baseline. AST levels also decreased significantly in the first (p = 0.047) and second months (p = 0.046), showing a consistent decline. Liv-Pro reduced total cholesterol, triglycerides, and Low-density lipoprotein (LDL) levels significantly after one and two months (p < 0.05) compared to baseline measurements. Abdominal ultrasound scans showed a significant decrease in hepatic fat content after two months (p = 0.020). Serum creatinine levels remained stable throughout the treatment period.</div></div><div><h3>Conclusion</h3><div>Liv-Pro was well-tolerated with no reported side effects, suggesting its potential as a safe and effective therapeutic option for NAFLD. Continuous administration of Liv-Pro is recommended for sustained efficacy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101196"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-10-16DOI: 10.1016/j.jaim.2025.101204
Anshul Narula, Sharad Porte, Anita Sharma
Laryngeal cancer is the most common malignant tumor among head and neck cancers in the world. Half of laryngeal cancers involve the vocal folds. Ayurvedic science being comprehensive, may not have described contemporary diseases as we read in modern texts. However, many contemporary diseases can be evaluated well by applying Ayurvedic diagnostic and therapeutic tools such as Nidana Panchaka, Agni (digestive fire) assessment, Dosha (body humors), Dhatu (body tissues), and Mala (excretory products), Srotas (body channels).
Here a case study of a 72 year old patient with chief complaint of hoarseness of voice and having biopsy confirmed as squamous cell carcinoma of left vocal cord is treated.
The patient was treated with Ayurvedic medications like Rakta prasadaka hima, kwatha prepared from Kanchnar bark, Yashtimadhu churana and Gomutra, combination of drugs which included jaharmohra pishti, Kahrva pishti, Tapyadi lauh, Vaikrant bhasma, Swarna bhasma, Heerak bhasma given with Drakshavaleh, Tab cytocruel AT, Kanthsudharak vati.
The size of nodule in CECT neck and GRBAS score (for hoarseness of voice) declined significantly after treatment and the voice of patient was improved.
Thus a case of carcinoma of left vocal cord treated successfully only with Ayurvedic treatment without any conventional therapy and with no side effects.
{"title":"Standalone Ayurvedic management of carcinoma of vocal cord - a case report","authors":"Anshul Narula, Sharad Porte, Anita Sharma","doi":"10.1016/j.jaim.2025.101204","DOIUrl":"10.1016/j.jaim.2025.101204","url":null,"abstract":"<div><div>Laryngeal cancer is the most common malignant tumor among head and neck cancers in the world. Half of laryngeal cancers involve the vocal folds. <em>Ayurvedic</em> science being comprehensive, may not have described contemporary diseases as we read in modern texts. However, many contemporary diseases can be evaluated well by applying <em>Ayurvedic</em> diagnostic and therapeutic tools such as <em>Nidana Panchaka</em>, <em>Agni</em> (digestive fire) assessment, <em>Dosha</em> (body humors), <em>Dhatu</em> (body tissues), and <em>Mala</em> (excretory products), <em>Srotas</em> (body channels).</div><div>Here a case study of a 72 year old patient with chief complaint of hoarseness of voice and having biopsy confirmed as squamous cell carcinoma of left vocal cord is treated.</div><div>The patient was treated with <em>Ayurvedic</em> medications like <em>Rakta prasadaka hima</em>, <em>kwatha</em> prepared from <em>Kanchnar</em> bark, <em>Yashtimadhu churana</em> and <em>Gomutra</em>, combination of drugs which included <em>jaharmohra pishti, Kahrva pishti, Tapyadi lauh</em>, <em>Vaikrant bhasma, Swarna bhasma, Heerak bhasma</em> given with <em>Drakshavaleh</em>, Tab cytocruel AT, <em>Kanthsudharak vati</em>.</div><div>The size of nodule in CECT neck and GRBAS score (for hoarseness of voice) declined significantly after treatment and the voice of patient was improved.</div><div>Thus a case of carcinoma of left vocal cord treated successfully only with Ayurvedic treatment without any conventional therapy and with no side effects.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101204"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-11-06DOI: 10.1016/j.jaim.2025.101258
Sanjeev Rastogi , Shashwat Rastogi
Urine retention is a common problem in elderly people. In male it is often associated with prostatic hypertrophy and can also be associated with hypo contractile bladder. Such functional disorders of bladder do not respond well to conventional medicine and the only respite is given by catheterization either in situ or intermittent as per the requirement. Besides social stigma, catheterization has its own accompanying problems leading to its poor acceptance. Newer approaches like electrical stimulation, Sacral neuro-modulation and stem cell therapy for this clinical condition are still in the process of development. Ayurveda earlier has reported to have successfully treated such cases to the extent of complete recovery. We present here a case of 83 year old male who was not able to pass the urine due to bladder hypo contractility and was on self-retaining catheter for about 2 years, got clinically cured with the help of Ayurveda interventions taken for about a year. A follow up of the case was done for another two years to find him well without any medication. This case endorses the worth of Ayurveda interventions in such cases and warrants a serious enquiry about such interventions to generate more robust evidences.
{"title":"Urine retention in elderly male due to hypo-contractile bladder treated successfully through Ayurveda – A Case Report","authors":"Sanjeev Rastogi , Shashwat Rastogi","doi":"10.1016/j.jaim.2025.101258","DOIUrl":"10.1016/j.jaim.2025.101258","url":null,"abstract":"<div><div>Urine retention is a common problem in elderly people. In male it is often associated with prostatic hypertrophy and can also be associated with hypo contractile bladder. Such functional disorders of bladder do not respond well to conventional medicine and the only respite is given by catheterization either in situ or intermittent as per the requirement. Besides social stigma, catheterization has its own accompanying problems leading to its poor acceptance. Newer approaches like electrical stimulation, Sacral neuro-modulation and stem cell therapy for this clinical condition are still in the process of development. Ayurveda earlier has reported to have successfully treated such cases to the extent of complete recovery. We present here a case of 83 year old male who was not able to pass the urine due to bladder hypo contractility and was on self-retaining catheter for about 2 years, got clinically cured with the help of Ayurveda interventions taken for about a year. A follow up of the case was done for another two years to find him well without any medication. This case endorses the worth of Ayurveda interventions in such cases and warrants a serious enquiry about such interventions to generate more robust evidences.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101258"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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