Journal of Ayurveda and Integrative Medicine最新文献_第4页

Characterization and effect of Naga Bhasma on hypoglycemic, antihyperglycemic, and antidiabetic activities in Charles Foster diabetic rats 那迦树对查尔斯·福斯特糖尿病大鼠降血糖、降高血糖和降糖尿病活性的表征和影响。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101226

Pravin Tate , B.J. Patgiri , P.K. Prajapati , B. Ravishankar

Background

Diabetes, typically characterized by hyperglycaemia, is a leading cause of morbidity and mortality. Over 800 million adults were estimated to have diabetes in 2022. Ayurveda texts emphasized on the antidiabetic potential of Naga Bhasma (NB) (a lead based formulation). Naga Bhasma is used in many classical antidiabetic formulations such as Vasantkusumakara Rasa.

Objectives

Present study was planned to evaluate hypoglycemic, antihyperglycemic, and antidiabetic activities of Naga Bhasma in euglycemic, sucrose loaded hyperglycemic and streptozotocin induced diabetic Charles Foster albino rats.

Material and methods

NB was prepared following classical texts of Ayurveda. Charles Foster albino rats were used for antidiabetic study. The study was divided into: hypoglycaemic, antihyperglycemic, and antidiabetic parts. Hypoglycaemic study was aimed to assess glucose lowering activity in normal rats. Antihyperglycemic study was carried out to assess the effect of test drug on blood sugar elevation observed after administration of sucrose (40 g/kg orally). For antidiabetic study, streptozotocin was injected intraperitoneally (40 mg/kg) to induce diabetes. Vehicles were administered on 3rd day of streptozotocin injection, after confirmation of diabetes. Blood sugar was checked before and on 5th day after vehicle administration. The data was analysed by unpaired ‘t’ test.

Results

Hypoglycaemic study did not show any significant effect on blood glucose in NB group. In Antihyperglycemic study, NB administered group showed only statistically non-significant increase in blood sugar level at 4th and 8th hour indicating presence of anti-hyperglycemic activity. In antidiabetic study, in control group, a statistically significant (48.90 %) elevation of blood sugar level was observed while in NB administered group highly significant (69.58 %) decrease was observed in comparison to initial values.

Conclusion

The study shows that NB has moderate anti-hyperglycaemic and good anti-diabetic activity; and it does not lower the blood glucose below the normal levels.

背景：糖尿病，以高血糖为典型特征，是发病率和死亡率的主要原因。到2022年，估计有超过8亿成年人患有糖尿病。阿育吠陀文献强调了那迦巴什玛（NB）（一种铅基制剂）的抗糖尿病潜力。在许多经典的抗糖尿病配方中，如Vasantkusumakara Rasa中使用了那伽巴什玛。目的：本研究拟评价长毛藤对高血糖、蔗糖负荷高血糖和链脲佐菌素诱导的糖尿病大鼠的降糖、降糖和降糖作用。材料和方法：NB是根据阿育吠陀经典文献制备的。采用Charles Foster白化大鼠进行抗糖尿病研究。该研究分为：降糖、降糖和降糖三个部分。降糖研究旨在评估正常大鼠的降糖活性。采用降糖研究评价试验药物对口服蔗糖（40 g/kg）后血糖升高的影响。在降糖研究中，腹腔注射链脲佐菌素（40 mg/kg）诱导糖尿病。在确认糖尿病后，于第3天给药链脲佐菌素。分别于给药前和给药后第5天检测血糖。数据采用非配对t检验进行分析。结果：降糖研究未发现NB组对血糖有明显影响。在降糖研究中，NB给药组仅在第4和第8小时血糖水平无统计学意义的升高，表明存在降糖活性。在降糖研究中，对照组血糖水平升高有统计学意义（48.90%），而给药组血糖水平较初始值显著降低（69.58%）。结论：研究表明，NB具有中等降糖和良好的抗糖尿病活性；而且它不会将血糖降低到正常水平以下。

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引用次数: 0

Traditional therapeutic practices in the Himalayan heartland of Kinnaur, Himachal Pradesh, India - A qualitative exploration 印度喜马偕尔邦金努尔喜马拉雅中心地带的传统治疗实践-定性探索。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101262

Abhishek Sharma , Qutsia Tabasum

Background

Traditional medicine systems have been essential components of health systems in rural areas, and areas with rich cultures and geographical isolation such as district Kinnaur. Derived from centuries of practice, these systems understand health and illness in terms of physical, mental, and socio-cultural well-being.

Objectives

This study documents the structural and functional aspects of the traditional medicine system prevalent in district Kinnaur, Himachal Pradesh, India, with a focus on understanding how traditional healers understand health, how they diagnose illness, and how they treat illnesses using traditional methods.

Material and methods

The present research was conducted in district Kinnaur, in the western Himalayas of Himachal Pradesh, India. This study is an exploratory qualitative research utilizing a thematic analysis approach (Braun and Clarke, 2006) to explore the traditional medicine system. The researcher collected data from all practicing traditional healers using an in-depth interview guide for the sessions.

Results

The traditional medicine system of district Kinnaur provides a holistic assessment of health and treatment of illness, incorporating all the aspects of the individual (physical, psychological, and socio-cultural). Structural and functional aspects of the traditional medicine system are documented under 6 major themes and sub-themes, which are 1) Concept of health, 2) Aetiology of Illness, 3) Diagnostic techniques, 4) Treatment methods, 5) Training and Learning process, 6) Production of medicine.

Conclusion

Traditional healers of Kinnaur have long classified, examined, and applied natural resource knowledge to develop therapeutic remedies. Understanding sociocultural patterns will aid policymakers in framing policies that would help sustain the age-old traditional knowledge of medicine, and it will also inform and sensitize healthcare providers to the beliefs and practices of their patients. In-depth interdisciplinary studies on the area's natural resources should be undertaken to understand active compounds of herbal plants used by traditional healers, which can validate traditional medicine through biomedical research.

背景：传统医学系统一直是农村地区以及具有丰富文化和地理隔离的地区（如Kinnaur区）卫生系统的重要组成部分。经过几个世纪的实践，这些系统从身体、精神和社会文化福祉的角度理解健康和疾病。目的：本研究记录了印度喜马偕尔邦Kinnaur地区流行的传统医学系统的结构和功能方面，重点是了解传统治疗师如何理解健康，他们如何诊断疾病，以及他们如何使用传统方法治疗疾病。材料和方法：本研究在印度喜马偕尔邦喜马拉雅山脉西部的Kinnaur地区进行。本研究是一项利用主题分析方法（Braun and Clarke, 2006）探索传统医学体系的探索性定性研究。研究人员使用深度访谈指南收集了所有执业传统治疗师的数据。结果：Kinnaur地区的传统医学系统提供了对健康和疾病治疗的整体评估，包括个人的所有方面（身体，心理和社会文化）。传统医学系统的结构和功能方面分为6个主题和子主题，即1)健康概念，2)疾病病因学，3)诊断技术，4)治疗方法，5)培训和学习过程，6)药物生产。结论：Kinnaur的传统治疗师长期以来对自然资源知识进行分类、检查和应用，以开发治疗方法。了解社会文化模式将有助于决策者制定有助于维持古老的传统医学知识的政策，并且还将使卫生保健提供者了解并敏感地了解患者的信仰和做法。应该对该地区的自然资源进行深入的跨学科研究，以了解传统治疗师使用的草药植物的活性化合物，这可以通过生物医学研究验证传统医学。

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引用次数: 0

Can cholesterol and its products serve as biomarkers for ojas? 胆固醇及其产物可以作为ojas的生物标志物吗？

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101240

Venil N. Sumantran , Pratibha P. Nair

Ojas is essential for human heath and vitality. In 1995, Walton et al. proposed an equivalence between ojas and cholesterol, and linked specific dhatus with steroid hormones derived from cholesterol. This paper examines five links between cholesterol and ojas. First, properties of ojas suggest a complex, mobile or immobile lipid. Only cholesterol has these properties. Insoluble, unesterified cholesterol maintains cell membranes. Cholesterol synthesized by the liver is converted into soluble cholesteryl lipoprotein esters (LDL-C and HDL-C), which circulate like apara ojas. Interestingly, cholesteryl-esters and apara ojas respond to diet and drugs. Second, eight biomolecules (five steroid hormones, bile acids, vitamin D, and myelin), which can only be synthesized from cholesterol, function at twelve physiological sites of ojas activity. Third, cholesterol and its products explain key functions of ojas. Thus, cholesterol controls reproduction, fertilization (shukra), and has a morphogenetic role in foetal development (garbhasara). Cholesterol and its products control stress responses, brain functions, and the musculoskeleton (bala). Cholesterol immunometabolism and vitamin D regulate immunity (vyadhi kshamatva). Fourth, oxidized LDL-C contributes to plaque formation in atherosclerosis, which is the leading cause of global deaths. Conversely, hypocholesterolemia and depleted ojas (ojo kshaya) significantly increase risk of mortality. Fifth, long term studies suggest that HDL-C can be a surrogate marker of healthy apara ojas. These facts indirectly prove that cholesterol homeostasis and robust ojas are absolute requirements for health and survival. We explain how these five links provide correlative, potentially causal, and clinical evidence for our hypothesis that cholesterol and products of cholesterol, are candidate biomarkers for ojas.

Ojas对人体健康和活力至关重要。1995年，Walton等人提出了ojas和胆固醇之间的等价关系，并将特异性dhatus与胆固醇衍生的类固醇激素联系起来。本文探讨了胆固醇和ojas之间的五个联系。首先，ojas的性质表明它是一种复杂的、可移动的或不可移动的脂质。只有胆固醇具有这些特性。不溶性、未酯化的胆固醇维持细胞膜。肝脏合成的胆固醇被转化为可溶性胆固醇脂蛋白酯（LDL-C和HDL-C），它们像空气一样循环。有趣的是，胆固醇酯和青蒿素对饮食和药物有反应。其次，只能由胆固醇合成的8种生物分子（5种类固醇激素、胆汁酸、维生素D和髓磷脂）在12个具有ojas活性的生理部位发挥作用。第三，胆固醇及其产物解释了ojas的关键功能。因此，胆固醇控制生殖、受精（shukra），并在胎儿发育（garbhasara）中起形态发生作用。胆固醇及其产物控制应激反应、脑功能和肌肉骨架（bala）。胆固醇免疫代谢和维生素D调节免疫力（vyadhi kshamatva）。第四，氧化LDL-C有助于动脉粥样硬化斑块的形成，这是全球死亡的主要原因。相反，低胆固醇血症和ojas （ojo kshaya）耗尽会显著增加死亡风险。第五，长期研究表明HDL-C可以作为健康皮肤的替代标记物。这些事实间接证明，胆固醇稳态和强健的ojas是健康和生存的绝对要求。我们解释了这五个联系如何为我们的假设提供相关的、潜在的因果关系和临床证据，即胆固醇和胆固醇产物是ojas的候选生物标志物。

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引用次数: 0

Ayurvedic management of a chronic venous ulcer using dusting of powdered botanicals – A Case Report 阿育吠陀管理慢性静脉溃疡使用粉末植物粉尘-一个病例报告

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101259

Arvind Singh Sisodia , Mahesh P. Jadhav , Sanjay C. Babar , Amit Paliwal , Priyanka D. Patil , Manvendra Singh Sisodia

Chronic venous ulcers (CVUs) pose a persistent challenge in clinical practice, especially among elderly individuals with comorbidities such as hypertension and venous insufficiency. Characterised by delayed healing, frequent recurrence, and impaired quality of life, these ulcers often remain unresponsive to conventional treatment. In recent years, Ayurveda has gained attention for its approach to chronic wound care, offering fewer side effects and greater cost-effectiveness.

This report details the case of a 74-year-old male with a history of varicose veins. He presented with a chronic, non-healing venous ulcer over the left lower limb, unresponsive to standard wound management. Diagnosed with a chronic venous ulcer.

The patient was managed with Avachoornan (dusting powdered botanicals), composed of equal parts of Shigru (Moringa oleifera), Nirgundi (Vitex negundo), and Guduchi (Tinospora cordifolia) powders. The dressing was applied once daily for four weeks. Progressive improvement in the wound was observed, with noticeable epithelialisation within 1 week.

This case demonstrates the potential of Avachoornan (dusting powdered botanicals) as a complementary approach during dressing in managing chronic venous ulcers, warranting further clinical evaluation.

慢性静脉溃疡（CVUs）在临床实践中是一个持续的挑战，特别是在患有高血压和静脉功能不全等合并症的老年人中。这些溃疡的特点是愈合延迟、频繁复发和生活质量受损，通常对常规治疗没有反应。近年来，阿育吠陀因其治疗慢性伤口的方法而受到关注，副作用更少，成本效益更高。本报告详细介绍了一例74岁男性静脉曲张病史。他表现为左下肢慢性静脉性溃疡，对标准伤口处理无反应。诊断为慢性静脉溃疡。患者使用Avachoornan（粉状植物药），由Shigru（辣木）、Nirgundi（白荆）和Guduchi（堇青花）粉末等份组成。这种敷料每天使用一次，持续四周。观察到伤口的进行性改善，1周内出现明显的上皮化。该病例证明了Avachoornan（植物粉末粉末）作为治疗慢性静脉溃疡敷料的补充方法的潜力，值得进一步的临床评估。

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引用次数: 0

Potential therapeutic use of Indian medicinal plants for preeclampsia management 印度药用植物对子痫前期管理的潜在治疗用途

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101218

Sheema Wazib, Yashesvi Ambardar, Huma Quasimi, Sushmita Alam, Sher Afghan, Md Iqbal Alam

Preeclampsia (PE), an adverse illness of pregnancy, poses significant risks to maternal and fetal health. Current management strategies focus on symptomatic relief and delivery, often neglecting the underlying pathophysiology. Indian medicinal plants, rich in bioactive compounds, offer a promising alternative by targeting oxidative stress, endothelial dysfunction, and inflammation, which are primary contributors to PE. Hemidesmus indicus exhibits strong anti-inflammatory and antioxidant properties, which may help reduce systemic inflammation and oxidative damage. Allium sativum (garlic) is well known for its ability to enhance nitric oxide (NO) bioavailability, promote vasodilation, and regulate blood pressure. Tribulus terrestris (Gokshura) supports cardiovascular health by stabilizing blood pressure and maintaining endothelial function. Curcuma longa (Turmeric) is known for its anti-inflammatory, antioxidant, and endothelial-protective effects. Withania somnifera (Ashwagandha) has adaptogenic and vasodilatory properties that contribute to improved vascular function and stress response. Rheum officinale (Rhubarb) has anti-inflammatory and vascular-protective effects, which may help improve maternal vascular health and reduce complications associated with PE. By addressing key pathological mechanisms, these medicinal plants offer a promising approach for PE management.

Among these medicinal plants, Asparagus racemosus willd. (AR) (Shatavari) has gained significant attention due to its rich composition of saponins, flavonoids, and antioxidants. These bioactive compounds play a crucial role in enhancing NO production, reducing oxidative stress, and improving endothelial function in PE. While traditional use supports their benefits, rigorous research is needed to confirm efficacy, safety and dosage. Integrating these botanicals into modern therapeutic protocols could offer a holistic and cost-effective strategy for PE management, ultimately improving maternal and fetal health outcomes.

先兆子痫（PE）是一种不良的妊娠疾病，对孕产妇和胎儿健康构成重大风险。目前的治疗策略侧重于症状缓解和分娩，往往忽视了潜在的病理生理。印度药用植物富含生物活性化合物，通过靶向氧化应激、内皮功能障碍和炎症（PE的主要诱因），提供了一种有希望的替代方案。半赤豆具有很强的抗炎和抗氧化特性，可能有助于减少全身炎症和氧化损伤。Allium sativum（大蒜）以其提高一氧化氮（NO）生物利用度、促进血管舒张和调节血压的能力而闻名。蒺藜（Gokshura）通过稳定血压和维持内皮功能支持心血管健康。姜黄以其抗炎、抗氧化和内皮保护作用而闻名。Withania somnifera （Ashwagandha）具有适应性和血管舒张特性，有助于改善血管功能和应激反应。大黄（大黄）具有抗炎和血管保护作用，可能有助于改善孕妇血管健康，减少PE相关并发症。通过解决关键的病理机制，这些药用植物为PE的管理提供了有前途的方法。在这些药用植物中，有野生总状芦笋。（AR）（Shatavari）因其丰富的皂苷、类黄酮和抗氧化剂成分而受到广泛关注。这些生物活性化合物在促进NO生成、减少氧化应激和改善PE内皮功能方面起着至关重要的作用。虽然传统用法支持它们的益处，但需要严格的研究来确认其功效、安全性和剂量。将这些植物药物整合到现代治疗方案中，可以为PE管理提供一个整体的、具有成本效益的策略，最终改善孕产妇和胎儿的健康结果。

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引用次数: 0

Padmabhushan Sri. Vaidhyabhushanam K. Raghavan Thirumulpad - an exemplary physician and guru Padmabhushan斯里兰卡。Vaidhyabhushanam K. Raghavan Thirumulpad——一位杰出的医生和古鲁。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101217

Nikhila Sankar M , Jyotsna Govindan , Aswin T. Das

引用次数: 0

A rheological study of human cranial cavity in shirodhara procedure using finite element method 用有限元法研究shirodhara手术中人类颅腔的流变学

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101263

K. Sivaselvi , E. Abhishek , M. Abhijith , V. Gautham , P.V. Anandaraman Sharma

Background

Shirodhara is a classical Ayurvedic therapy involving the continuous pouring of medicated liquids on the forehead to treat stress, insomnia, migraines, and neurological disorders. However, its underlying biomechanical mechanisms remain poorly understood.

Objective

To simulate and analyze the biomechanical response of cranial tissues during Shirodhara using water, cow milk, and sesame oil, investigate the rheological behavior of the human cranial vault and assess their relative therapeutic efficacy.

Methods

A forehead-skull model is developed in ANSYS Workbench to simulate fluid impact under controlled flow conditions. Key parameters such as velocity distribution, pressure gradient, total deformation, shear stress, and von Mises stress are evaluated for each fluid.

Results

Sesame oil exhibits the highest velocity (1.13 m/s), pressure gradient (up to 587 Pa), and shear stress due to its greater viscosity and density. This resulted in more pronounced micro-stresses and tissue deformations compared to milk and water.

Conclusion

Sesame oil demonstrated the most effective mechanical interaction with the cranial structure during Shirodhara, which correlates with its well-documented benefits in anxiety reduction, improved sleep, and nervous system regulation.

shirodhara是一种经典的阿育吠陀疗法，包括在额头上连续倾倒药液来治疗压力、失眠、偏头痛和神经系统疾病。然而，其潜在的生物力学机制仍然知之甚少。目的模拟和分析水、牛奶和香油在Shirodhara过程中颅脑组织的生物力学反应，探讨人颅穹的流变学行为，评价其相对治疗效果。方法在ANSYS Workbench中建立额骨-颅骨模型，模拟受控流动条件下的流体冲击。对每种流体的速度分布、压力梯度、总变形、剪切应力和von Mises应力等关键参数进行了评估。结果由于其较大的粘度和密度，芝麻油表现出最高的速度（1.13 m/s）、压力梯度（高达587 Pa）和剪切应力。与牛奶和水相比，这导致了更明显的微应力和组织变形。结论芝麻油在Shirodhara过程中与颅骨结构的机械相互作用最为有效，这与芝麻油在减少焦虑、改善睡眠和调节神经系统方面的益处有关。

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引用次数: 0

Remission in ulcerative colitis with standalone Ayurveda intervention: A Case Report 单独阿育吠陀干预缓解溃疡性结肠炎：1例报告。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101227

Sanjeev Rastogi , Krishna Gopal Sharma

Ulcerative Colitis (UC) is an autoimmune disorder presents with bloody diarrhea. This responds well to conventional medicine including steroids but recurrences are frequent once the treatment is stopped. Present report is about a case of UC having frequent recurrence of symptoms with ongoing conventional medicine, having treated with Ayurveda interventions to the extent of remission like state followed up for over 1 year. The case proposes that Ayurveda interventions in refractory cases of UC can be of value to provide long term remission and sustained clinical relief.

The patient treated here was a young girl having blood mixed loose stools 10–15 times a day and ongoing weight loss. With conventional treatment, there were partial responses followed by the recurrences once the treatment stopped. Endoscopic finding were suggestive of multiple ulcers in the colon and rectum. On the basis of clinical and endoscopic findings, the patient was diagnosed for UC. Considering it as aam-raktaj pravahika, Ayurveda interventions were individualized for the patient. Following the Ayurveda treatment for about 1 year, patient reported reduced frequency of stool with blood along with weight gain. Endoscopic observation after one year reveled no ulcers in the colon and rectum.

This report suggests that in cases of refractory UC, it is worth trying other therapeutic options like Ayurveda as these may provide additional relief and reduced frequency of relapses. Based upon such observations, more systematic clinical trials are required to be planned to evaluate these therapeutic options in cases of UC.

溃疡性结肠炎（UC）是一种以带血腹泻为表现的自身免疫性疾病。这对包括类固醇在内的常规药物反应良好，但一旦停止治疗，复发是常见的。本文报告1例UC患者在持续常规药物治疗后症状频繁复发，经阿育吠陀干预治疗至缓解状态，随访1年以上。该病例表明，阿育吠陀干预难治性UC病例可以提供长期缓解和持续的临床缓解的价值。这里治疗的病人是一个年轻的女孩，每天有10-15次血混合稀便，体重持续下降。在常规治疗中，有部分反应，一旦停止治疗就会复发。内窥镜检查提示结肠和直肠多发溃疡。根据临床和内镜检查结果，诊断为UC。考虑到它是am-raktaj pravahika，阿育吠陀的干预措施是针对患者个性化的。阿育吠陀治疗约1年后，患者报告大便带血次数减少，体重增加。内镜下观察一年后未发现结肠和直肠溃疡。该报告表明，对于难治性UC，值得尝试其他治疗方案，如阿育吠陀，因为这些可能提供额外的缓解和减少复发的频率。基于这些观察结果，需要计划更系统的临床试验来评估UC病例中的这些治疗方案。

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引用次数: 0

Ayurvedic management of uterine fibroids with a cervical Polyp - A case report 阿育吠陀治疗子宫肌瘤伴宫颈息肉1例报告

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101221

Vidyasagar Panchal , Malashree Panchal , Deepa , Veena

Uterine fibroids are of major concern in women's life, which are the most common causes of conditions like Abnormal Uterine Bleeding (AUB), Dysmenorrhea that can negatively affect their life. The increased global incidence of Hysterectomies due to uterine fibroids and Polyps in society is of major concern. Even though polyps are generally not advised for hysterectomy, but when it is associated with unresponsive AUB/Malignant changes may require hysterectomy. Ayurveda can manage these clinical conditions in a very cost-effective way without any surgical intervention.

In this report, we are presenting the case of a women in her mid-forties with complaints of abnormal uterine bleeding, pain in the abdomen, and back pain. USG scan had revealed two fibroids of size 1.6cm each in the fundus of the uterus, and a cervical polyp of 3∗2.4 cm and PID For which she had been advised to undergo Hysterectomy. Here an effort has been made to treat the condition with the available Ayurvedic management and to avoid surgery. The patient was treated with Ayurvedic medications, and Uttarabasti was carried out once every cycle. After 3 months of treatment, the patient was free of all the symptoms and the follow-up scan revealed the absence of all the above impressions. The patient has not reported any negative feedback regarding her condition or treatment methods. This article intends to bring confidence in young Ayurvedic practitioners, that Ayurveda can manage such solid benign uterine growths with non-surgical methods.

子宫肌瘤是女性生活中的主要问题，它是导致子宫异常出血（AUB）、痛经等疾病的最常见原因，这些疾病会对她们的生活产生负面影响。由于子宫肌瘤和息肉引起的子宫切除术在全球的发病率越来越高，这是社会关注的主要问题。尽管息肉通常不建议切除子宫，但当它伴有无反应的AUB/恶性变化时，可能需要切除子宫。阿育吠陀可以在不需要任何手术干预的情况下以一种非常经济有效的方式管理这些临床状况。在本报告中，我们提出的情况下，妇女在她的45岁中期的投诉异常子宫出血，腹部疼痛，背部疼痛。USG扫描显示子宫底有两个1.6cm大小的肌瘤，一个3 * 2.4 cm的宫颈息肉和PID，因此她被建议进行子宫切除术。在这里，人们努力用现有的阿育吠陀治疗方法来治疗这种疾病，避免手术。患者接受阿育吠陀药物治疗，每周期进行一次Uttarabasti。治疗3个月后，患者所有症状消失，随访扫描显示上述所有印象均不存在。患者未报告任何关于其病情或治疗方法的负面反馈。本文旨在为年轻的阿育吠陀从业者带来信心，阿育吠陀可以用非手术方法治疗这种固体良性子宫生长。

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引用次数: 0

Exploring the interaction hotspots of p-glycoprotein with herbal bioactives: In silico insights for integrative Ayurvedic therapeutics 探索p-糖蛋白与草药生物活性的相互作用热点：阿育吠陀综合治疗的计算机洞察。

IF 1.9 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.jaim.2025.101238

Chandana Roy, Pratiti Ghosh

Background

The human multidrug resistant efflux transporter p-glycoprotein plays a crucial role in the pharmacokinetics of xenobiotics, mediating their elimination from systemic circulation. Its overexpression contributes to multidrug resistance, posing challenges to effective therapeutic interventions.

Objectives

This study integrates Ayurvedic and contemporary biomedical research to investigate hotspot residues involved in the interaction of p-glycoprotein with bioactives from medicinal herbs to enhance the understanding of its substrate recognition and transport mechanisms.

Material and methods

The 3D structure of 6C0V was docked with 789 herbal ligand molecules utilizing the CDOCKER programme in Biovia Discovery Studio (version 4.5, 2021), revealing key residues involved in binding interactions. Alanine scanning mutagenesis was performed to evaluate the functional importance of these residues by analyzing changes in binding affinity through molecular docking.

Result

The study identified residues Ser979, Glu972, Leu332, Phe336, Leu976, Thr76, Leu975, Gly737 and Phe732 as potential hotspots for binding and inhibition of ligand efflux into the extracellular compartment. Targeting these energetically important residues with herbal compounds can guide the development of small-molecule drugs that bind with high specificity and reduce off-target interactions, minimizing undesirable side effects.

Conclusion

This study provides insight into the structural basis of p-glycoprotein-herbal ligand interactions, aiding in the design of specific plant-based inhibitors for overcoming multidrug resistance in treatment of chronic diseases.

背景：人类多药耐药外排转运蛋白p-糖蛋白在外源药物的药代动力学中起着至关重要的作用，介导其从体循环中消除。它的过表达导致多药耐药，对有效的治疗干预提出了挑战。目的：本研究结合阿育吠陀医学和当代生物医学研究，研究p-糖蛋白与中草药生物活性相互作用的热点残基，以加深对其底物识别和转运机制的理解。材料和方法：利用Biovia Discovery Studio（版本4.5,2021）的CDOCKER程序，将6C0V的3D结构与789种草药配体分子对接，揭示了参与结合相互作用的关键残基。通过分子对接分析结合亲和力的变化，利用丙氨酸扫描诱变来评价这些残基的功能重要性。结果：研究发现Ser979、Glu972、Leu332、Phe336、Leu976、Thr76、Leu975、Gly737和Phe732等残基是结合和抑制配体外排进入细胞外室的潜在热点。用草药化合物靶向这些能量上重要的残基可以指导小分子药物的开发，这些药物具有高特异性结合，减少脱靶相互作用，最大限度地减少不良副作用。结论：本研究揭示了p-糖蛋白-草药配体相互作用的结构基础，有助于设计特异性植物抑制剂来克服慢性疾病治疗中的多药耐药。

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