Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Arvind Kulkarni,&nbsp;Swapna Kulkarni,&nbsp;Vasanti Godse,&nbsp;Shrinivas Datar,&nbsp;Sushama Bhuvad,&nbsp;Shweta Gujar,&nbsp;Sameer Gore,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Vinita Awalkanthe,&nbsp;Anita Shingte,&nbsp;Sneha Dalvi,&nbsp;Vijay Radye,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.101070","DOIUrl":"10.1016/j.jaim.2024.101070","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits when used as a complementary therapy in combination with conventional treatment through various herbal, herbo-mineral or herbo-mineral-metallic formulations. One of such formulations, <em>Raupya Suvarna Sutshekhara (RSS),</em> has <em>Raupya bhasma</em> and <em>Suvarna bhasma</em> (incinerated Silver and Gold respectively) ingredients and they are described as <em>Rasayana</em> (immunomodulatory) and possess <em>Medhya</em> (enhances the brain functions and intelligence) activity.</div></div><div><h3>Objective</h3><div>The study documents effects of <em>Raupya Suvarna Sutshekhara</em> in alleviating symptoms of malignant brain tumors.</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study was done for malignant brain tumor patients (n = 110) registered at our centre who were treated with <em>Raupya Suvarna Sutshekhara</em> 125 mg–250 mg (a herbo-mineral metallic formulation) as a treatment of choice of neural tonic along with supporting Ayurvedic medicines. Treatment response evaluation period ranged from 3 months to 5 years (median period 29 weeks). Clinical symptoms, weight, Karnofsky Performance Score (KPS), Quality of Life (QoL) score, and survival data with respect to treatment with RSS were analyzed.</div></div><div><h3>Results</h3><div>RSS showed a very significant (<em>p</em> &lt; 0.001) effect on symptoms related to memory loss, headache, imbalance, loss of appetite, and generalized weakness while significant (<em>p</em> &lt; 0.05) decrease in urinary incontinence, seizures, difficulty in thinking/articulating, and weakness in one part/side of the body. However, a not-quite significant change was seen in symptom confusion/disorientation. No significant improvement was seen in vision changes, facial numbness or tingling, swallowing difficulties, and tingling in extremities. Body weight and KPS also showed improvement. Patients with treatment between 2 and 5 years showed median survival up to 62 months.</div></div><div><h3>Conclusions</h3><div>It was observed that adjunct Ayurvedic treatment with RSS helped to reduce the severity of symptoms due to the tumor itself or side-effects of conventional treatments, maintain the quality of life of malignant brain tumor patients and has shown to increase survival with respect to the duration of the treatment.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101070"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda management of migraine - a case report","authors":"Giramalla Patil ,&nbsp;Shivanand Patil ,&nbsp;Prateek Hosur","doi":"10.1016/j.jaim.2024.100983","DOIUrl":"10.1016/j.jaim.2024.100983","url":null,"abstract":"<div><div>Migraine is one of the most prevalent causes of functional disability worldwide. Migraine patients experience headaches of varying degrees, which are related with a higher level of disability and are triggered by psychological and physiological stressors. Migraine is estimated to affect 16.6% of the world's population, with women being three times more likely to experience it than men. Despite considerable advancements in modern and traditional medicine, a complete cure remains uncertain. In <em>Ayurvedic</em> treatises, migraine headache is referred to as <em>Ardhavabedhaka</em> under the classification of <em>Shiroroga</em> (diseases related to the head region).</div><div>35-year-old Indian male police inspector, suffering from recurrent right hemi-cranial headaches once in three days for the last three months, presented symptoms of <em>Tridhoshaja Ardhvabhedaka</em> (Migraine) associated with <em>Amlapitta</em> (hyperacidity).</div><div>After a thorough assessment of the patient, the treatment was meticulously planned based on the patient's <em>Dosha pradhanyatha</em> and <em>Vyadhi avastha</em> <em>(stage of disease)</em>. For the proper <em>Samprapti vighatana, Nidana parivarjana</em> (abstinance from the eitiological factors), <em>Deepana, Paachana, Siravyadha</em>, <em>Nasya</em> and <em>Dosha Shaman</em><em>a</em> <em>Chikitsa</em> principles were adopted. Further, the severity of the migraine was assessed by MIDAS and NPR score, which subsequently decreased from 19 to 4, and the NPR scale decreased from 8 to 2 till completion of the therapeutic intervention.</div><div>This case report unequivocally highlights the pivotal role of the Ayurveda treatment regimen in effectively managing migraine. Overall, effective treatment of migraine cases requires the correct assessment of <em>Dosha</em> status and <em>Vyadhi avastha</em> and the correct selection of the appropriate medicine and procedures like <em>Siravyadha and Nasya</em> at that appropriate stage of the disease.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100983"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of systemic sclerosis - A case report","authors":"Jagruti R. Parmar ,&nbsp;Naiya Upadhyay ,&nbsp;Manish V. Patel ,&nbsp;Shivenarain N. Gupta","doi":"10.1016/j.jaim.2024.100956","DOIUrl":"10.1016/j.jaim.2024.100956","url":null,"abstract":"<div><p>Scleroderma, an autoimmune connective tissue disorder, leads to skin and tissue thickening. In this autoimmune disease condition, the defense mechanism works against the body itself and mistakenly attacks normal cells. Ayurveda links it to <em>vatarakta</em>, initially affecting <em>tvak</em>, <em>rakta</em>, and <em>mamsa</em>. <em>Vata</em> is primarily involved, but as the disease progresses, all <em>doshas</em> and <em>dhatu</em> get involved.</p><p>A 45-year-old woman presented with skin hardening, skin depigmentation all over her body, limb stiffness, weakness, arthralgia, anorexia, constipation and burning in the chest region for the last three years.</p><p>She was diagnosed with diffuse systemic sclerosis (SSc) but as per Ayurveda we can correlate with <em>aamvata</em> and <em>vatarakta</em> based on her <em>lakshanas</em>(symptoms).</p><p>Ayurvedic treatment commenced with <em>vardhamana pippali</em>(<em>Piper longum</em>)<em>rasayan</em>, <em>svedana karma</em>, and <em>virechan karma</em>, followed by <em>basti</em>(enema) <em>chikitsa (pathyadi kvath niruh basti)</em> and oral ayurvedic medication viz., <em>Manjisthadi kvatha</em>, <em>kaishora guggulu</em>, <em>Jatamansi(Nardostachys Jatamansi) churna, mishreya(Foeniculum vulgare) arka, dashang churna</em> with water for local application and daily <em>shamanarth panchtikta ghrit.</em></p><p>After 8 weeks, depigmentation was reduced, new hair growth emerged, mild skin softening occured, chest burning, anorexia, sleeplessness was decreased and enhanced mental well-being.</p><p>The treatment aimed to balance vitiated doshas and dhatu while alleviating symptoms, and enhancing overall well-being, demonstrating the efficacy of the holistic approach in managing scleroderma through Ayurveda.</p><p>Auto-immune disorder, scleroderma, chronic complications, skin tightness, salt pepper depigmentation, sclerodactyly.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100956"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000718/pdfft?md5=da9d36f463e172d0440b1f4e0ad8b25e&pid=1-s2.0-S0975947624000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-center, randomized, open label, two-arm study to evaluate safety & efficacy of nutraceutical tablet as adjuvant when compared with standard of care in patients with benign prostatic hyperplasia","authors":"Suresh B. Patankar ,&nbsp;Anupama Patankar ,&nbsp;Sagar Patankar ,&nbsp;Rajesh Raje ,&nbsp;Chandu Devanpally ,&nbsp;Pranjal Ausekar ,&nbsp;GauravPatil ,&nbsp;Shraddha Chitale","doi":"10.1016/j.jaim.2024.100971","DOIUrl":"10.1016/j.jaim.2024.100971","url":null,"abstract":"<div><h3>Background</h3><div>Benign Prostrate Hyperplasia (BPH) is a progressive disease of ageing men that may be associated with enlargement of the prostate and lower urinary tract symptoms (LUTS). Herbal/Nutraceutical formulations in addition to standard of care (SOC) could alleviate the symptoms, and thus improve the quality of life of patients.</div></div><div><h3>Objectives</h3><div>To evaluate safety &amp; efficacy of nutraceutical tablet as an adjuvant with SOC.</div></div><div><h3>Materials and Methods</h3><div>This was a prospective, randomized two-arm study aimed to assess the safety and efficacy of Herbal/Nutraceutical Formulation (IP) + SOC versus only SOC, in BPH patients. The primary efficacy endpoint was the change in international prostate symptom score (IPSS) within and between two arms. The safety was evaluated in terms of adverse events and change in prostate specific antigen (PSA) levels.</div></div><div><h3>Results</h3><div>140 eligible patients (70 / arm) were evaluated for efficacy and safety endpoints. The baseline characteristics of patients in two arms differed nonsignificantly. The change in IPSS-storage, voiding and QoL scores, from day 1 to 90 were statistically significant in both the arms (p &lt; 0.0001). However, by day 90, the change in these scores in SOC+IP arm were significantly higher than that of SOC arm. Further, the change in International Index of Erectile Function (IIEF) scores was significant in SOC+IP arm (p &lt; 0.05), while non-significant in SOC arm. The adverse events non-significantly differed between two arms.</div></div><div><h3>Conclusion</h3><div>The herbal/nutraceutical formulation combined with SOC are safe and effective for the treatment of BPH. The combination therapy was effective in reducing urine-related symptoms and improving the QoL of BPH patients.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100971"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Ayurvedic philosophy with modern technologies for drug research and development: A critical need of mechanistic insights for wider acceptability","authors":"Chavan Sandeep ,&nbsp;Vidya Gupta ,&nbsp;Vineeta Deshmukh ,&nbsp;Sadanand Sardeshmukh","doi":"10.1016/j.jaim.2024.100954","DOIUrl":"10.1016/j.jaim.2024.100954","url":null,"abstract":"<div><div>Ayurveda is a holistic science emphasizing healing and maintaining harmony and balance in the body. Medicines from natural resources and in pre-defined dosage forms are integral parts of successful Ayurvedic treatment in various diseases including complex ailments, such as cancer. Ayurvedic medicines are cocktails of several active phyto-compounds and/or natural resources and no isolated/purified molecules are used in the treatment. However, various unique methods employed using natural media, such as water, lipids, buttermilk, and lemon juice, just to name a few, lead to the elimination of unwanted constituents/impurities and enhance the bioavailability and efficacy of the drug. Such plausible alterations, selection, and/or retention of signature phytocompounds in the raw materials, during the process, and in the final drug need to be studied for precise product identification and analysis. Critical standardization of the manufacturing procedures is, therefore, mandatory for quality fidelity, assurance, and optimum efficacy. Moreover, the simultaneous multi-level and/or multi-targeted actions of Ayurvedic medicines against various dysfunctions due to their complex nature makes it extremely challenging to understand the mechanistic aspects during pre-clinical and clinical studies.</div><div>The present article focuses on probable challenges and ideal roadmaps for standardization and characterization of such herbal as well as metallic-mineral Ayurvedic medicines being used for various simple and complex diseases like cancer and their treatments. It is emphasized that Ayurvedic manufacturing procedures should be followed meticulously and the finished product be characterized thoroughly using advanced pharmaceutical and analytical techniques. It is also accentuated that detailed monographs or dossiers including shelf-life studies need to be officially published for knowledge dissemination and worldwide acceptance. Finally, safety and efficacy studies as per modern pharmacology ought to be conducted in suitable animal models for the judicious use of these medicines. Mainstream or adjuvant treatment of dreadful diseases such as cancer with Ayurvedic medicines will only be fruitful through rational experimentation and ethical reporting.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100954"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of hemangiomatous ulcer: A case report","authors":"Praveen Kumar Yadav ,&nbsp;Laxmikant S.D.","doi":"10.1016/j.jaim.2024.101056","DOIUrl":"10.1016/j.jaim.2024.101056","url":null,"abstract":"<div><div>The most frequent infantile tumor is a hemangioma, and its most common complication is ulceration. A quickly progressing ulcer called a hemangioma can also result in secondary infection. The mechanism of ulcer formation is unknown but is thought to develop during the rapid growth phase. Infantile hemangiomas are diagnosed clinically, based on the progression of the lesion's history and a clinical examination. Physical interventions (laser surgery, cryosurgery, excision) and systemic corticosteroids or beta-blockers are the usual course of treatment; all carry the potential for substantial side effects. A two-month young female baby approached us, with a diagnosis of hemangiomatous ulcer. Skin grafting was advised by a plastic surgeon, but the baby's parents approached for Ayurveda treatment. The case was treated with oral medicine bilwadi agada and external treatments vranaprakshalana with triphala kwatha and jatyadi taila local application for 2 months. There was complete healing of the ulcer.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101056"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and cytotoxicity properties of a polyherbal mouthwash containing Achyranthes aspera and Trachyspermum ammi against selected periodontal pathogens","authors":"Ram Surath Kumar ,&nbsp;Anil V. Ankola ,&nbsp;Mahantesh B. Nagamoti ,&nbsp;Roopali M. Sankeshwari ,&nbsp;Kishori P. Sutar ,&nbsp;Shushant I. Jigan ,&nbsp;Atrey J. Pai Khot","doi":"10.1016/j.jaim.2024.101046","DOIUrl":"10.1016/j.jaim.2024.101046","url":null,"abstract":"<div><h3>Background</h3><div>Chlorhexidine (CHX) is considered as a gold standard for its antibacterial efficacy and substantivity in chemical plaque control. However, some adverse effects are associated with its prolonged use. Herbal medicines like <em>Achyranthes aspera</em> and <em>Trachyspermum ammi</em> have been used in many clinical conditions, and they appear to be a valuable substitute next to CHX in the management of periodontal diseases.</div></div><div><h3>Objective</h3><div>This <em>in vitro</em> study was designed to assess and compare the antibacterial potential and cytotoxic effects of novel polyherbal mouthwash containing <em>A. aspera</em> and <em>T. ammi</em> with 0.2% CHX mouthwash against <em>Porphyromonas gingivalis, Tannerella forsythia,</em> and <em>Aggregatibacter actinomycetemcomitans</em>.</div></div><div><h3>Methods</h3><div>Ethanolic extracts of <em>A. aspera</em> and <em>T. ammi</em> were prepared by the Soxhlet apparatus method and were subjected to preliminary phytochemical screening. The individual plant extracts and the plant extract mixture (PEM) of <em>A. aspera</em> and <em>T. ammi</em> in the ratio of 1:1, 2:1, 1:2 (<em>w/v</em>) were assessed for minimum inhibitory concentration (resazurin microtitre assay) and minimum bactericidal concentration (spread plating method) against selected periodontal pathogens in comparison to CHX. The polyherbal mouthwash was assessed for zone of inhibition (well diffusion method) and cytotoxicity (MTT assay) on adult human gingival fibroblasts. All the experiments were performed in triplicate.</div></div><div><h3>Results</h3><div>The antibacterial activity was evident in the PEMs, and polyherbal mouthwash against tested periodontal pathogens and was comparable to CHX. The cytotoxicity assay findings confirmed that polyherbal mouthwash exhibited 82.1% of surviving cells which proved good biocompatibility.</div></div><div><h3>Conclusion</h3><div><em>A. aspera</em> and <em>T. ammi</em> based mouthwash possess comparable antibacterial activity against periodontal pathogens when compared to CHX.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101046"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies","authors":"Anitha Kuttiappan ,&nbsp;Santenna Chenchula ,&nbsp;Murugesan Vanangamudi ,&nbsp;Shvetank Bhatt ,&nbsp;Radhika Chikatipalli ,&nbsp;P Shaila Bhanu ,&nbsp;Nagaraju Bandaru","doi":"10.1016/j.jaim.2024.101036","DOIUrl":"10.1016/j.jaim.2024.101036","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Phytochemicals and their derivatives are promising target drugs for various ailments and have served as therapeutic agents for several decades. Using &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; models and molecular docking, this study investigated the pharmacological potential of a flavonoid-rich fraction of the ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; (SG).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;p&gt;This research aimed to determine whether flavonoid-rich whole-plant extracts of SGs have any cytoprotective or &lt;em&gt;in vivo&lt;/em&gt; hepatoprotective effects. Additionally, the study was intended to elucidate the molecular connections between the discovered flavonoid flavonols and PPARα target proteins linked to liver problems, for which an in silico molecular docking investigation was performed.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;p&gt;To separate the flavonoid components, the entire &lt;em&gt;Sesbania grandiflora&lt;/em&gt; plant was first extracted using ethanol as a solvent by soxhlet extraction. The resulting ethanolic extract was then fractionated. The cytoprotective and hepatoprotective properties were evaluated via &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; experiments. SGOT, SGPT, triglyceride, bilirubin, and total protein levels were used to evaluate hepatotoxicity in animal models. &lt;em&gt;In vitro&lt;/em&gt; studies on Hepatocellular Carcinoma G2 (HepG2) cell lines have examined their cytotoxic effects and antioxidant activity. The most promising flavonoid-flavanol compounds were identified by conducting molecular docking studies against PPARα target protein (PDB ID: &lt;span&gt;&lt;span&gt;3VI8&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;) using MOE software.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;&lt;em&gt;In vivo&lt;/em&gt;, the serum levels of SGOT, SGPT, total triglyceride and total bilirubin were measured in experimental animals treated with the flavonoid-rich ethanolic extract of SG. Significant reductions in the levels of these hepatic injury markers were observed, indicating the hepatoprotective potential of the extract. Elevated levels of liver biomarkers in the untreated group indicated liver injury or dysfunction. The treated groups showed significant restoration of these biomarkers, suggesting the hepatoprotective potential of &lt;em&gt;SG&lt;/em&gt;. The IC&lt;sub&gt;50&lt;/sub&gt; value for the total flavonoid content of SG was 190.28 μg/ml, indicating its safety in inhibiting HepG2 cell growth. Flavonoid treatment decreased cell viability but did not affect antioxidant parameters in hepatocytes. In addition, SG restored the damaged hepatocyte architecture. Molecular docking studies revealed the binding affinities of flavonoids for PPARα. These findings suggest that a promising lead candidate for the development of therapeutic medicines against anti-TB drug-induced hepatotoxicity has been identified.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Our findings demonstrate the hepatoprotective potential of the flavonoid-rich fraction of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; both &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101036"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001517/pdfft?md5=0f7fc8a45bc8f15450e3737f599c90e3&pid=1-s2.0-S0975947624001517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural study on the uses of traditional herbal medicine to treat various women's health issues in Northeast India","authors":"Klaret Kropi,&nbsp;K.P. Jastone,&nbsp;Sweety Angelirie Kharumnuid,&nbsp;Hemanta Kumar Das,&nbsp;Moses M. Naga","doi":"10.1016/j.jaim.2024.101024","DOIUrl":"10.1016/j.jaim.2024.101024","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;This cross-cultural study conducted in the diverse regions of Assam, Meghalaya, and Manipur sheds light on the common utilization of five specific medicinal plants among indigenous communities residing in these areas.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The main focus of this study is to document and compare the traditional medicinal plant used and the knowledge and practices related to women's health issues in different cultures; to identify commonalities and differences in the use of medicinal plants across cultures and various medicinal plants used traditionally by the indigenous communities to treat women's health problems according to their indigenous name, scientific name.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;The study used a survey method and a pre-structured interview schedule through one-on-one interactive communication and field observation. The authors collected data from three different states, i.e., Assam (Karbi Anglong district &amp; Udalguri district), Meghalaya (East Khasi Hills district), and Manipur (Senapati district) by personally meeting and interacting with traditional herbal medicinal practitioners. For this study, 10 practitioners from each area of study were interviewed. During the data collection process, the vernacular name of the medicinal plant, methods of preparation, mode of application, and probable dosage were compiled and documented involving practitioners belonging to four different communities, i.e, Bodo, Karbi, Khasi, and Poumai Naga of the selected states.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 39 plant species were meticulously collected and documented across the Karbi Anglong district and Udalguri district in Assam, East Khasi Hills district in Meghalaya, and Senapati district in Manipur. Turmeric (&lt;em&gt;Curcuma longa&lt;/em&gt;), ginger (&lt;em&gt;Zingiber officinale&lt;/em&gt;), gooseberry (&lt;em&gt;Emblica officinalis&lt;/em&gt;), papaya (&lt;em&gt;Carica papaya&lt;/em&gt;), and passion fruit (&lt;em&gt;Passiflora edulis)&lt;/em&gt; have emerged as common medicinal resources within these communities. Poaceae, represented by 5 species, emerged as the dominant family among the collected plants, highlighting the diversity and significance of these botanical remedies. &lt;em&gt;Zingiber officinale&lt;/em&gt; Roscoe \" has the highest usage report of 18 with an RFC (Relative frequency citation) of 0.45.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The study's findings reveal a rich repository of traditional herbal knowledge in the northeast regions of India. Notably, the indigenous communities of these regions use plant resources to cure a wide range of ailments. This study emphasizes the necessity of documenting, preserving, and transmitting traditional herbal medicinal knowledge for both cultural and practical reasons. It also provides vital insights into the importance of cross-cultural study in promoting different cultures, the richness of traditional medicinal knowledge by engaging with diverse cultures and demonstrates ","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101024"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001396/pdfft?md5=0d1e78e724747eaf81fd946f8f26c940&pid=1-s2.0-S0975947624001396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of post-hysterectomy urinary incontinence with composite Ayurveda treatment – A case report","authors":"Ranjani Karthik Pandit","doi":"10.1016/j.jaim.2024.100961","DOIUrl":"10.1016/j.jaim.2024.100961","url":null,"abstract":"<div><div>This is a case report of a patient who developed urinary incontinence after undergoing abdominal hysterectomy. This was successfully treated with Ayurvedic treatment procedures. A 63-year-old lady was suffering from urinary incontinence, which developed after hysterectomy. It did not subside even after undergoing trans vaginal taping. She was treated with Ayurvedic procedures and medicines for a period of 2 and a half months from 4^th of March 2016 to 26^th of May 2016. <em>Matrabasti</em> (medicated enema) and <em>Madhutailika</em> <em>basti</em> (enema treatment with honey and oil), along with other palliative medicines – <em>S</em><em>ukumara ghrita, Chandraprabha vati,</em> <em>S</em><em>hilajatu,</em> <em>M</em><em>ahakalyanaka kashaya,</em> <em>M</em><em>amsapachaka ghana vati and Mahatiktaka ghrita</em> were given to the patient. Urinary incontinence reduced to dribbling of urine after Matra basti and after the second course of <em>B</em><em>asti</em> (medicated enema), that is after one and half months, patient stopped using diapers and was relieved from incontinence. This case report summarises the effective management of urinary incontinence by adopting basti (enema) treatment along with other palliative ayurvedic medicine.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100961"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}