Pub Date : 2026-02-03DOI: 10.1016/j.jaim.2025.101272
Manchal Shivappa Puja, Kothanath Bhaskaran Jyothy, Varuni Kulkarni, S Srihari
Duchenne Muscular Dystrophy is a debilitating X-linked genetic disorder that manifests in early childhood with progressive muscle weakness, loss of ambulation, and ultimately, respiratory and cardiac failure resulting in premature mortality. A nine-year-old male patient presented with the inability to stand and ambulate without assistance, which had persisted since six years of age. He had been previously diagnosed with Duchenne Muscular Dystrophy, and his parents provided the relevant diagnostic documents. The patient exhibited weakness in the lower extremities, poor appetite, irregular bowel habits, and irritability. The clinical manifestations were evaluated from an Ayurvedic perspective, and a corresponding treatment plan was subsequently devised. The treatment regimen spanned 4 months, consisting of 6 sessions with an interval of 15-20 days between each clinical visit. The therapeutic approach encompassed major interventions such as external and internal Swedana, Basti, and oral medications. Concurrently, internal medications and appropriate dietary modifications were incorporated. The internal medications included herbs like Sida cordifolia L, Withania somnifera, Terminalia chebula Retz, Bacopa monneri, and Zingiber officinale Roxb. Additional herbs with proven Immunomodulatory, Antioxidant, and Anti-Inflammatory properties were also utilized. Physiotherapy was continued as part of the overall management strategy. Following the third treatment session, the child exhibited the ability to stand with the support of a cot, grasp and throw a stone - abilities that were not previously observed prior to the therapies. Additionally, by the end of the first month, improvements were noted in the patient's appetite and bowel habits. The comprehensive Ayurvedic approach, when combined with physiotherapy, demonstrated enhancements in symptoms such as relief from constipation, the capacity to stand with cot support, subtle changes in the upper limb muscle tone, and an overall enhancement in the child's quality of life. This study highlights the potential of Ayurveda as a complementary approach to conventional treatment.
{"title":"Potential benefits of Ayurveda in Duchenne muscular Dystrophy: A case based analysis.","authors":"Manchal Shivappa Puja, Kothanath Bhaskaran Jyothy, Varuni Kulkarni, S Srihari","doi":"10.1016/j.jaim.2025.101272","DOIUrl":"10.1016/j.jaim.2025.101272","url":null,"abstract":"<p><p>Duchenne Muscular Dystrophy is a debilitating X-linked genetic disorder that manifests in early childhood with progressive muscle weakness, loss of ambulation, and ultimately, respiratory and cardiac failure resulting in premature mortality. A nine-year-old male patient presented with the inability to stand and ambulate without assistance, which had persisted since six years of age. He had been previously diagnosed with Duchenne Muscular Dystrophy, and his parents provided the relevant diagnostic documents. The patient exhibited weakness in the lower extremities, poor appetite, irregular bowel habits, and irritability. The clinical manifestations were evaluated from an Ayurvedic perspective, and a corresponding treatment plan was subsequently devised. The treatment regimen spanned 4 months, consisting of 6 sessions with an interval of 15-20 days between each clinical visit. The therapeutic approach encompassed major interventions such as external and internal Swedana, Basti, and oral medications. Concurrently, internal medications and appropriate dietary modifications were incorporated. The internal medications included herbs like Sida cordifolia L, Withania somnifera, Terminalia chebula Retz, Bacopa monneri, and Zingiber officinale Roxb. Additional herbs with proven Immunomodulatory, Antioxidant, and Anti-Inflammatory properties were also utilized. Physiotherapy was continued as part of the overall management strategy. Following the third treatment session, the child exhibited the ability to stand with the support of a cot, grasp and throw a stone - abilities that were not previously observed prior to the therapies. Additionally, by the end of the first month, improvements were noted in the patient's appetite and bowel habits. The comprehensive Ayurvedic approach, when combined with physiotherapy, demonstrated enhancements in symptoms such as relief from constipation, the capacity to stand with cot support, subtle changes in the upper limb muscle tone, and an overall enhancement in the child's quality of life. This study highlights the potential of Ayurveda as a complementary approach to conventional treatment.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"101272"},"PeriodicalIF":1.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarcopenia is a degenerative musculoskeletal condition that affects older persons with the hallmark of loss of muscle mass and function. Modern management is limited to nutrition, exercise, and lifestyle modifications, with no approved drugs. Ayurveda recognizes a similar condition called Mamsa kshaya due to vitiation of Vata dosha, which reflects the clinical picture of sarcopenia, and offers Ayush Ahara, a therapeutic dietary approach.
To assess the clinical evidence for the role of traditional Indian diet (∼Ayush ahara) in improving muscle strength and managing sarcopenia.
A scoping review was conducted according to PRISMA-ScR. Literature published from 2015 to 2025 was searched across various databases. Inclusion criteria: randomized controlled trials involving human subjects assessing the effect of traditional Indian diet on muscle strength-related outcomes. Non-English, non-full-text, in vitro/in vivo studies, and reviews were excluded.
The nine studies were included. Ayush ahara, such as green gram, dried grapes, turmeric, cow milk, finger millet, spinach, and almonds, was associated with improved muscle strength, physical performance, reduced inflammation, and enhanced bone mineral density.
Ayush ahara shows potential for improving muscle strength and managing sarcopenia. The reviewed RCTs showed statistical improvements in muscle strength measures, indicating the need for targeted clinical trials to validate these preliminary findings. Support further exploration of Ayurveda-based nutritional strategies as a complementary approach to musculoskeletal aging.
{"title":"Efficacy of traditional Indian diet (Ayush ahara) on muscle strength and Sarcopenia: A scoping review","authors":"Rahul Katkar , Usha Rana , Sriloy Mohanty , Monika Pathania","doi":"10.1016/j.jaim.2025.101265","DOIUrl":"10.1016/j.jaim.2025.101265","url":null,"abstract":"<div><div>Sarcopenia is a degenerative musculoskeletal condition that affects older persons with the hallmark of loss of muscle mass and function. Modern management is limited to nutrition, exercise, and lifestyle modifications, with no approved drugs. Ayurveda recognizes a similar condition called <em>Mamsa kshaya</em> due to vitiation of <em>Vata dosha</em>, which reflects the clinical picture of sarcopenia, and offers <em>Ayush Ahara</em>, a therapeutic dietary approach.</div><div>To assess the clinical evidence for the role of traditional Indian diet (∼<em>Ayush ahara</em>) in improving muscle strength and managing sarcopenia.</div><div>A scoping review was conducted according to PRISMA-ScR. Literature published from 2015 to 2025 was searched across various databases. Inclusion criteria: randomized controlled trials involving human subjects assessing the effect of traditional Indian diet on muscle strength-related outcomes. Non-English, non-full-text, in vitro/in vivo studies, and reviews were excluded.</div><div>The nine studies were included. <em>Ayush ahara,</em> such as green gram, dried grapes, turmeric, cow milk, finger millet, spinach, and almonds, was associated with improved muscle strength, physical performance, reduced inflammation, and enhanced bone mineral density.</div><div><em>Ayush ahara</em> shows potential for improving muscle strength and managing sarcopenia. The reviewed RCTs showed statistical improvements in muscle strength measures, indicating the need for targeted clinical trials to validate these preliminary findings. Support further exploration of Ayurveda-based nutritional strategies as a complementary approach to musculoskeletal aging.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101265"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jaim.2025.101269
Ramakrishna Allam , B. Kothainayagi , P.A. Sudhir , Vanitha R. Muralikumar , Muthuvel Arumugam , C.R. Rene Robin , S. Yokesh , U. Vishali , S. Fahima
The AYUSH sector relies mainly on medicinal plants and metals, which form the foundation of traditional healing practices. However, all plants are often inaccessible to many students due to geographic and seasonal limitations. To bridge this gap, Ayurveda Medical College, in collaboration with, Incubation Center and Engineering College, initiated a pilot project to develop a Virtual Herbal Garden a Solution for problem statement given by All India Institute of Ayurveda, under Smart India Hackathon 2024. This digital platform offers an immersive, interactive, and user-friendly learning experience, enabling users to explore medicinal plants in detail. The garden includes 3D models, multimedia resources, and comprehensive information on five medicinal plants: Cassia fistula, Ocimum sanctum, Aloe vera, Mentha piperita, and Azadirachta indica. The Virtual Herbal Garden is expected to become a valuable educational tool, promoting awareness and understanding of plants used in traditional medicine in the AYUSH sector.
{"title":"Virtual herbal garden (Hayushasutra): An educational aid for Ayurveda students","authors":"Ramakrishna Allam , B. Kothainayagi , P.A. Sudhir , Vanitha R. Muralikumar , Muthuvel Arumugam , C.R. Rene Robin , S. Yokesh , U. Vishali , S. Fahima","doi":"10.1016/j.jaim.2025.101269","DOIUrl":"10.1016/j.jaim.2025.101269","url":null,"abstract":"<div><div>The AYUSH sector relies mainly on medicinal plants and metals, which form the foundation of traditional healing practices. However, all plants are often inaccessible to many students due to geographic and seasonal limitations. To bridge this gap, Ayurveda Medical College, in collaboration with, Incubation Center and Engineering College, initiated a pilot project to develop a Virtual Herbal Garden a Solution for problem statement given by All India Institute of Ayurveda, under Smart India Hackathon 2024. This digital platform offers an immersive, interactive, and user-friendly learning experience, enabling users to explore medicinal plants in detail. The garden includes 3D models, multimedia resources, and comprehensive information on five medicinal plants: <em>Cassia fistula</em>, <em>Ocimum sanctum</em>, <em>Aloe vera</em>, <em>Mentha piperita</em>, and <em>Azadirachta indica</em>. The Virtual Herbal Garden is expected to become a valuable educational tool, promoting awareness and understanding of plants used in traditional medicine in the AYUSH sector.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101269"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jaim.2025.101271
Urmila J. Shirke , Payal P. Wavhal
{"title":"Need for a centralized repository of standardized validated scales and disease gradation tools for clinical research in Ayurveda","authors":"Urmila J. Shirke , Payal P. Wavhal","doi":"10.1016/j.jaim.2025.101271","DOIUrl":"10.1016/j.jaim.2025.101271","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101271"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jaim.2025.101285
Liang-Jun Lu , Xin-Yi Lu , Xiu-Zu Song , Ai-E Xu
Skin abscess is a common bacterial infection of the skin and soft tissues. Conventional treatment typically involves incision and drainage after pus formation, which may lead to prolonged healing and surgical scarring. Traditional Chinese Medicine (TCM) has extensive experience in treating infectious diseases with the potential for rapid recovery and minimal scarring; however, international literature on its efficacy remains limited. We present three cases of skin abscess successfully treated with an oral modified Xian Fang Huo Ming Yin (XFHMY) decoction based on syndrome differentiation.
Case 1
A 29-year-old male presented with a painful, swollen plaque on the left upper back persisting for over two weeks.
Case 2
A 12-year-old girl with a red, swollen mass on the left waist for more than 10 days.
Case 3
A 35-year-old male with a painful, erythematous plaque on the inner right upper arm for half a month.
After 5–7 days of TCM treatment, all abscesses resolved completely without significant scarring, and only mild hyperpigmentation or depression remained. These findings suggest that TCM, particularly modified XFHMY, may serve as an effective non-invasive alternative therapy for skin abscesses.
{"title":"A novel effective treatment for skin abscess using traditional Chinese herbal medicine: a case series","authors":"Liang-Jun Lu , Xin-Yi Lu , Xiu-Zu Song , Ai-E Xu","doi":"10.1016/j.jaim.2025.101285","DOIUrl":"10.1016/j.jaim.2025.101285","url":null,"abstract":"<div><div>Skin abscess is a common bacterial infection of the skin and soft tissues. Conventional treatment typically involves incision and drainage after pus formation, which may lead to prolonged healing and surgical scarring. Traditional Chinese Medicine (TCM) has extensive experience in treating infectious diseases with the potential for rapid recovery and minimal scarring; however, international literature on its efficacy remains limited. We present three cases of skin abscess successfully treated with an oral modified Xian Fang Huo Ming Yin (XFHMY) decoction based on syndrome differentiation.</div></div><div><h3>Case 1</h3><div>A 29-year-old male presented with a painful, swollen plaque on the left upper back persisting for over two weeks.</div></div><div><h3>Case 2</h3><div>A 12-year-old girl with a red, swollen mass on the left waist for more than 10 days.</div></div><div><h3>Case 3</h3><div>A 35-year-old male with a painful, erythematous plaque on the inner right upper arm for half a month.</div><div>After 5–7 days of TCM treatment, all abscesses resolved completely without significant scarring, and only mild hyperpigmentation or depression remained. These findings suggest that TCM, particularly modified XFHMY, may serve as an effective non-invasive alternative therapy for skin abscesses.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101285"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jaim.2025.101270
Mohd Asad Farooqi, Kantrol Kumar Sahu
Colorectal cancer (CRC) is a serious worldwide health concern associated with chronic inflammation and dysregulation of numerous signaling pathways, including IL-6/STAT3, NF-κB, COX-2/PGE2, and IL-23/Th17. These pathways aid in tumour development and progression by increasing the manufacture of inflammatory mediators, anti-apoptotic gene expression, cell proliferation, and angiogenesis. Lupeol, a naturally occurring lupine-type pentacyclic triterpenoid, has sparked widespread interest due to its several pharmacological qualities, which include antioxidant, anti-inflammatory, anticancer, and antibacterial capabilities. Despite its enormous medicinal promise, low water solubility and bioavailability have hampered its clinical use. Recent advances in nano-based delivery systems and the invention of lupeol derivatives have increased its bioavailability and bioactivity, making it a promising candidate for CRC treatment. This study seeks to inspire additional research into lupeol's significance as a nutraceutical intervention in CRC by integrating current knowledge and investigating novel techniques to increase its clinical efficacy.
{"title":"Signaling pathways and molecular mechanisms of lupeol in colorectal cancer: A comprehensive review","authors":"Mohd Asad Farooqi, Kantrol Kumar Sahu","doi":"10.1016/j.jaim.2025.101270","DOIUrl":"10.1016/j.jaim.2025.101270","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is a serious worldwide health concern associated with chronic inflammation and dysregulation of numerous signaling pathways, including IL-6/STAT3, NF-κB, COX-2/PGE2, and IL-23/Th17. These pathways aid in tumour development and progression by increasing the manufacture of inflammatory mediators, anti-apoptotic gene expression, cell proliferation, and angiogenesis. Lupeol, a naturally occurring lupine-type pentacyclic triterpenoid, has sparked widespread interest due to its several pharmacological qualities, which include antioxidant, anti-inflammatory, anticancer, and antibacterial capabilities. Despite its enormous medicinal promise, low water solubility and bioavailability have hampered its clinical use. Recent advances in nano-based delivery systems and the invention of lupeol derivatives have increased its bioavailability and bioactivity, making it a promising candidate for CRC treatment. This study seeks to inspire additional research into lupeol's significance as a nutraceutical intervention in CRC by integrating current knowledge and investigating novel techniques to increase its clinical efficacy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101270"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jaim.2025.101266
Rabia Malik , Mohd Aleemuddin Quamri , Galib R , Muzafar Din Ahmad Bhat , Mehjabeen Fatimah
Materiovigilance is the practice of monitoring and ensuring the safety of medical devices by identifying, assessing, and mitigating risks associated with their use. While this concept is well-established in modern medicine, its foundational principles can also be traced back to Unani literature, which emphasizes the safe and effective use of tools and instruments in traditional therapies. The integration of materiovigilance into the Unani system of medicine is a significant step towards enhancing patient safety and ensuring the efficacy of traditional healthcare practices. Unani medicine, known for its holistic approach, incorporates various therapeutic regimens such as Ḥijama(Cupping Therapy), Fasd(Venesection), Taliq al-‘Alaq(Leech Therapy), etc., many of which involve the use of medical devices and instruments. These devices, ranging from simple tools to complex instruments, pose varying levels of risk to patients. In this review, the concept of materiovigilance, its relevance to the Unani system, and the importance of its integration to ensure patient safety and improve treatment outcomes have been examined. It categorizes Unani therapeutic devices based on their risk levels—low, moderate, and high—underscoring the need for tailored monitoring and safety measures for each category. The paper also discusses the challenges and opportunities in implementing materiovigilance within Unani practices. The adoption of such measures is crucial for safeguarding patient health, maintaining the quality of traditional therapies, and aligning with international safety and regulatory standards. This integration not only supports the sustainable development of Unani medicine but also strengthens its role in the broader healthcare landscape.
{"title":"Integration of materiovigilance in Unani medicine: A step towards patient safety","authors":"Rabia Malik , Mohd Aleemuddin Quamri , Galib R , Muzafar Din Ahmad Bhat , Mehjabeen Fatimah","doi":"10.1016/j.jaim.2025.101266","DOIUrl":"10.1016/j.jaim.2025.101266","url":null,"abstract":"<div><div>Materiovigilance is the practice of monitoring and ensuring the safety of medical devices by identifying, assessing, and mitigating risks associated with their use. While this concept is well-established in modern medicine, its foundational principles can also be traced back to Unani literature, which emphasizes the safe and effective use of tools and instruments in traditional therapies. The integration of materiovigilance into the Unani system of medicine is a significant step towards enhancing patient safety and ensuring the efficacy of traditional healthcare practices. Unani medicine, known for its holistic approach, incorporates various therapeutic regimens such as <em>Ḥijama</em>(Cupping Therapy), <em>Fasd</em>(Venesection), <em>Taliq al-‘Alaq</em>(Leech Therapy), etc., many of which involve the use of medical devices and instruments. These devices, ranging from simple tools to complex instruments, pose varying levels of risk to patients. In this review, the concept of materiovigilance, its relevance to the Unani system, and the importance of its integration to ensure patient safety and improve treatment outcomes have been examined. It categorizes Unani therapeutic devices based on their risk levels—low, moderate, and high—underscoring the need for tailored monitoring and safety measures for each category. The paper also discusses the challenges and opportunities in implementing materiovigilance within Unani practices. The adoption of such measures is crucial for safeguarding patient health, maintaining the quality of traditional therapies, and aligning with international safety and regulatory standards. This integration not only supports the sustainable development of Unani medicine but also strengthens its role in the broader healthcare landscape.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101266"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.jaim.2025.101151
Bhushan Patwardhan
{"title":"","authors":"Bhushan Patwardhan","doi":"10.1016/j.jaim.2025.101151","DOIUrl":"10.1016/j.jaim.2025.101151","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101151"},"PeriodicalIF":1.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.jaim.2025.101225
Xiange Huang , Hegen Li , Ziming Li , Yilin Yao
Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.
{"title":"Oral administration of osimertinib mesylate induced multiple peripheral neuropathy of a non-small-cell lung cancer patient and treated with traditional Chinese medicine - A case report","authors":"Xiange Huang , Hegen Li , Ziming Li , Yilin Yao","doi":"10.1016/j.jaim.2025.101225","DOIUrl":"10.1016/j.jaim.2025.101225","url":null,"abstract":"<div><div>Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101225"},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.jaim.2025.101181
Somit Kumar , Kavitha Singh , Santhi Krishna A S
Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time. The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.
{"title":"Efficacy of standalone personalized Ayurveda management in moderating functional index, inflammatory markers & radiological progression in Ankylosing Spondylitis with 12 years follow up – A case report","authors":"Somit Kumar , Kavitha Singh , Santhi Krishna A S","doi":"10.1016/j.jaim.2025.101181","DOIUrl":"10.1016/j.jaim.2025.101181","url":null,"abstract":"<div><div>Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time<strong>.</strong> The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101181"},"PeriodicalIF":1.9,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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