Pub Date : 2025-12-23DOI: 10.1016/j.jaim.2025.101151
Bhushan Patwardhan
{"title":"","authors":"Bhushan Patwardhan","doi":"10.1016/j.jaim.2025.101151","DOIUrl":"10.1016/j.jaim.2025.101151","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101151"},"PeriodicalIF":1.9,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.jaim.2025.101225
Xiange Huang , Hegen Li , Ziming Li , Yilin Yao
Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.
{"title":"Oral administration of osimertinib mesylate induced multiple peripheral neuropathy of a non-small-cell lung cancer patient and treated with traditional Chinese medicine - A case report","authors":"Xiange Huang , Hegen Li , Ziming Li , Yilin Yao","doi":"10.1016/j.jaim.2025.101225","DOIUrl":"10.1016/j.jaim.2025.101225","url":null,"abstract":"<div><div>Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101225"},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.jaim.2025.101181
Somit Kumar , Kavitha Singh , Santhi Krishna A S
Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time. The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.
{"title":"Efficacy of standalone personalized Ayurveda management in moderating functional index, inflammatory markers & radiological progression in Ankylosing Spondylitis with 12 years follow up – A case report","authors":"Somit Kumar , Kavitha Singh , Santhi Krishna A S","doi":"10.1016/j.jaim.2025.101181","DOIUrl":"10.1016/j.jaim.2025.101181","url":null,"abstract":"<div><div>Ankylosing Spondylitis (AS) with extra-skeletal involvement predisposes patients to progressive axial spine complications affecting Quality of Life (QoL), if left untreated. A 21-year-old HLA B27 positive female affected with AS for twelve years, with multiple relapses and remissions had safety analysis of standalone Ayurvedic therapy during two pregnancies. Baseline and during disease flare-ups revealed elevated CRP levels. The current case reports the safety and efficacy of individualized Ayurveda interventions in ameliorating the progressive pathophysiology of AS with no clinical progression or radiological joint damage over time<strong>.</strong> The relative remission rate and progressive pathogenesis of AS can either be contained or arrested through Ayurveda, thereby improving the prognosis and QoL of an individual.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101181"},"PeriodicalIF":1.9,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duchenne Muscular Dystrophy (DMD; OMIM #310200) and Becker Muscular Dystrophy (BMD; OMIM #300376) are rare and severe genetic conditions. These X-linked recessive Muscular Dystrophies (MDs) stem from variants in the DMD gene (OMIM #300377), encoding the dystrophin protein (Uniprot #P11532). The Prakriti concept, adjudged in Ayurveda, epitomizes an individual's nature-nurture and has gained significance in healthcare with the emerging field of Ayurgenomics.
Objective
The present research thoroughly analyses demographic, clinical, genetic, and Prakriti profiles in the D/BMD patients of Gujarat, India by integrating ancient wisdom with modern paradigms.
Materials and methods
This observational study included 120 male participants whose demographic and clinical data were assessed. The concentration of total CPK was measured. Genetic analysis methods, viz. MPCR, MLPA, and NGS were applied to identify variants. Prakriti profiles of all participants were assessed using AyuSoft.
Results
The demographic and clinical aspects of the study highlight the heterogeneity in disease severity and progression, with 15.83% of familial cases. The difference in CPK levels between DMD (12,445.15 U/L) and BMD (8,095 U/L) underscores the usual gradient in severity seen in these two types. Comprehensive genetic analysis revealed 87.5% DMD and 12.5% BMD, where 90% were identified as deletions, 4.17% duplications, and 5.83% point variants. In the cohort, 84.96% of variants were out-of-frame and 15.04% in-frame. Variant events were predominantly in distal regions (78.33%) and involved the central hotspot domain (65.83%). Among the detected deletions, 45-52 deletions exhibited dominantly in DMD participants with heightened frequency for exon 50. The study uniquely integrates Ayurvedic Prakriti profiles into the analysis, contributing additional insight into the disease framework. Based on seven distinct Prakritis, three profiles emerged prominently within our study. These are KaphapradhaanaPittaanubandhi (KP), KaphapradhaanaVaataanubandhi (KV), and VaatapradhaanaKaphaanubandhi (VK). The distribution of Prakriti differed between DMD and BMD participants. In both groups, 46.67% had KP Prakriti, whereas DMD had 40.95% KV and 12.38% VK. Conversely, 53.33% of BMD participants had KV Prakriti, and VK Prakriti was absent.
Conclusion
The varying distribution of profiles introduces possibilities for Prakriti-based stratification of D/BMD. The multiple Factor Analysis (MFA) highlights the importance of age and Severity in the analysis. Such integrative Ayurgenomics holds promise for a deeper comprehension of genetic conditions and for paving the way for the development of innovative, real-time, and personalized management.
{"title":"Prakriti and genetic profiling in Duchenne/Becker muscular dystrophy: An Ayurgenomic appraisal towards personalized care","authors":"Pooja Trivedi , Dhruv Prajapati , Krishnakumari Patel , Khushi Dhamecha , Gaurang Sindhav","doi":"10.1016/j.jaim.2025.101241","DOIUrl":"10.1016/j.jaim.2025.101241","url":null,"abstract":"<div><h3>Background</h3><div>Duchenne Muscular Dystrophy (DMD; OMIM #310200) and Becker Muscular Dystrophy (BMD; OMIM #300376) are rare and severe genetic conditions. These X-linked recessive Muscular Dystrophies (MDs) stem from variants in the DMD gene (OMIM #300377), encoding the dystrophin protein (Uniprot #P11532). The Prakriti concept, adjudged in Ayurveda, epitomizes an individual's nature-nurture and has gained significance in healthcare with the emerging field of Ayurgenomics.</div></div><div><h3>Objective</h3><div>The present research thoroughly analyses demographic, clinical, genetic, and Prakriti profiles in the D/BMD patients of Gujarat, India by integrating ancient wisdom with modern paradigms.</div></div><div><h3>Materials and methods</h3><div>This observational study included 120 male participants whose demographic and clinical data were assessed. The concentration of total CPK was measured. Genetic analysis methods, <em>viz.</em> MPCR, MLPA, and NGS were applied to identify variants. Prakriti profiles of all participants were assessed using AyuSoft.</div></div><div><h3>Results</h3><div>The demographic and clinical aspects of the study highlight the heterogeneity in disease severity and progression, with 15.83% of familial cases. The difference in CPK levels between DMD (12,445.15 U/L) and BMD (8,095 U/L) underscores the usual gradient in severity seen in these two types. Comprehensive genetic analysis revealed 87.5% DMD and 12.5% BMD, where 90% were identified as deletions, 4.17% duplications, and 5.83% point variants. In the cohort, 84.96% of variants were out-of-frame and 15.04% in-frame. Variant events were predominantly in distal regions (78.33%) and involved the central hotspot domain (65.83%). Among the detected deletions, 45-52 deletions exhibited dominantly in DMD participants with heightened frequency for exon 50. The study uniquely integrates Ayurvedic Prakriti profiles into the analysis, contributing additional insight into the disease framework. Based on seven distinct Prakritis, three profiles emerged prominently within our study. These are <em>Kaphapradhaana</em> <em>Pittaanubandhi</em> (KP), <em>Kaphapradhaana</em> <em>Vaataanubandhi</em> (KV), and <em>Vaatapradhaana</em> <em>Kaphaanubandhi</em> (VK). The distribution of Prakriti differed between DMD and BMD participants. In both groups, 46.67% had KP Prakriti, whereas DMD had 40.95% KV and 12.38% VK. Conversely, 53.33% of BMD participants had KV Prakriti, and VK Prakriti was absent.</div></div><div><h3>Conclusion</h3><div>The varying distribution of profiles introduces possibilities for Prakriti-based stratification of D/BMD. The multiple Factor Analysis (MFA) highlights the importance of age and Severity in the analysis. Such integrative Ayurgenomics holds promise for a deeper comprehension of genetic conditions and for paving the way for the development of innovative, real-time, and personalized management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101241"},"PeriodicalIF":1.9,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101224
Anjali Singh , Sanjoy Majhi , Arnab Das
Background
Suryanamaskar (SN) is popular amongst recent yoga practitioners for its health benefits and fitness promises. Most previous studies have focused on the long-term pre-post effects of SN intervention on health and fitness. However, a notable gap exists regarding the immediate response of practicing SN on cardiorespiratory and neuro-cognitive functions, especially in the female population.
Objectives
This study aimed to find the immediate effect of SN practice on cardiorespiratory functions and neuro-cognitive performance in healthy adult females.
Material and methods
A total of 21 healthy females (aged: 18–25 years) were selected in this Quasi pre-post experimental study, guided by the CONSORT tool. Cardiorespiratory, heart rate (HR) variability, and cognitive parameters were assessed before and immediately after 45 minutes of SN session using a metabolic gas analyzer, HR sensor, and psychometric tests, respectively. Paired t-test was performed to find the difference between the pre- and post-SN responses.
Results
A significant increase in average volume of oxygen consumption (VO2) (11.4 %; p < 0.01), minute ventilation (VE) (15.9 %; p < 0.001), respiratory frequency (Rf) (6.2 %; p < 0.01), respiratory quotient (RQ) (4.6 %; p < 0.01), and METS (12.4 %; p < 0.001) were observed immediately after SN session. No significant changes in blood pressure was observed. LF power (23.7 %; p < 0.01) and LF/HF ratio (79.9 %; p < 0.05) showed a significant increase along with a decrease in pNN50 % (16.9 %; p < 0.05) and HF power (16.4 %; p < 0.01) at post-SN. A significant improvement (p < 0.01) in Stroop congruent (14.78 %) and incongruent (13.7 %) reaction times was also observed immediately after the SN session.
Conclusion
These findings collectively indicate that a single session of SN effectively enhanced both cardiorespiratory and cognitive functions, which can be used to improve cardiometabolic health and to train the autonomic nervous system in females.
suryanamaskar （SN）因其健康益处和健身承诺在最近的瑜伽练习者中很受欢迎。以往的研究大多集中在SN干预对健康和健身的长期前后影响上。然而，关于SN练习对心肺和神经认知功能的即时反应，特别是在女性人群中，存在明显的差距。目的探讨瑜伽练习对健康成年女性心肺功能和神经认知功能的直接影响。材料与方法采用CONSORT工具进行准实验前后研究，选取年龄在18-25岁的健康女性21例。分别使用代谢气体分析仪、心率传感器和心理测量测试评估心肺、心率（HR）变异性和认知参数。配对t检验发现sn前后反应的差异。结果SN治疗后，平均耗氧量（VO2） （11.4%; p < 0.01）、分钟通气量（VE） （15.9%; p < 0.001）、呼吸频率（Rf） （6.2%; p < 0.01）、呼吸商（RQ） （4.6%; p < 0.01）和METS （12.4%; p < 0.001）均显著升高。血压未见明显变化。sn后低频段功率（23.7%;p < 0.01）和低频段/高频比（79.9%;p < 0.05）显著升高，pNN50 % （16.9%; p < 0.05）和高频功率（16.4%;p < 0.01）显著降低。在Stroop一致（14.78%）和不一致（13.7%）的反应时间上也有显著改善（p < 0.01）。结论单次SN可有效增强女性的心肺功能和认知功能，可用于改善女性心脏代谢健康和训练自主神经系统。
{"title":"Immediate effect of Suryanamaskar on cardiorespiratory functions and cognitive performance: A quasi-experimental study on young adult females","authors":"Anjali Singh , Sanjoy Majhi , Arnab Das","doi":"10.1016/j.jaim.2025.101224","DOIUrl":"10.1016/j.jaim.2025.101224","url":null,"abstract":"<div><h3>Background</h3><div>Suryanamaskar (SN) is popular amongst recent yoga practitioners for its health benefits and fitness promises. Most previous studies have focused on the long-term pre-post effects of SN intervention on health and fitness. However, a notable gap exists regarding the immediate response of practicing SN on cardiorespiratory and neuro-cognitive functions, especially in the female population.</div></div><div><h3>Objectives</h3><div>This study aimed to find the immediate effect of SN practice on cardiorespiratory functions and neuro-cognitive performance in healthy adult females.</div></div><div><h3>Material and methods</h3><div>A total of 21 healthy females (aged: 18–25 years) were selected in this Quasi pre-post experimental study, guided by the CONSORT tool. Cardiorespiratory, heart rate (HR) variability, and cognitive parameters were assessed before and immediately after 45 minutes of SN session using a metabolic gas analyzer, HR sensor, and psychometric tests, respectively. Paired <em>t</em>-test was performed to find the difference between the pre- and post-SN responses.</div></div><div><h3>Results</h3><div>A significant increase in average volume of oxygen consumption (VO<sub>2</sub>) (11.4 %; p < 0.01), minute ventilation (VE) (15.9 %; p < 0.001), respiratory frequency (Rf) (6.2 %; p < 0.01), respiratory quotient (RQ) (4.6 %; p < 0.01), and METS (12.4 %; p < 0.001) were observed immediately after SN session. No significant changes in blood pressure was observed. LF power (23.7 %; p < 0.01) and LF/HF ratio (79.9 %; p < 0.05) showed a significant increase along with a decrease in pNN50 % (16.9 %; p < 0.05) and HF power (16.4 %; p < 0.01) at post-SN. A significant improvement (p < 0.01) in Stroop congruent (14.78 %) and incongruent (13.7 %) reaction times was also observed immediately after the SN session.</div></div><div><h3>Conclusion</h3><div>These findings collectively indicate that a single session of SN effectively enhanced both cardiorespiratory and cognitive functions, which can be used to improve cardiometabolic health and to train the autonomic nervous system in females.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101224"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-alcoholic Fatty Liver Disease (NAFLD) involves excessive fat build-up in the liver unrelated to alcohol use. This study aimed to evaluate the clinical efficacy and safety of Liv-Pro capsules, a formulation combining Osbeckia octandra and Aloe vera, in managing NAFLD. This is the first report of the clinical trial using this combination against NAFLD.
Methods
A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 NAFLD patients from February 1, 2021 to March 31, 2023. Participants received either Liv-Pro or a placebo (two capsules once a day) for two months. Medical assessments at baseline, one month, and two months included liver function tests (ALT and AST), abdominal ultrasound scan, serum creatinine analysis, and lipid profile assessment. All patients were advised on lifestyle modifications.
Results
Liv-Pro significantly reduced ALT levels after one month (p = 0.049) and two months (p = 0.048) compared to baseline. AST levels also decreased significantly in the first (p = 0.047) and second months (p = 0.046), showing a consistent decline. Liv-Pro reduced total cholesterol, triglycerides, and Low-density lipoprotein (LDL) levels significantly after one and two months (p < 0.05) compared to baseline measurements. Abdominal ultrasound scans showed a significant decrease in hepatic fat content after two months (p = 0.020). Serum creatinine levels remained stable throughout the treatment period.
Conclusion
Liv-Pro was well-tolerated with no reported side effects, suggesting its potential as a safe and effective therapeutic option for NAFLD. Continuous administration of Liv-Pro is recommended for sustained efficacy.
{"title":"A randomised double blind placebo-controlled clinical trial to evaluate the effects of Liv-Pro- a food supplement for Non-Alcoholic Fatty Liver Disease","authors":"Anchala Ishani Kuruppu , Uditha Prabhath Liyanage , Aruni Chamika , Priyani Asoka Paranagama , Lankani Hettigoda","doi":"10.1016/j.jaim.2025.101196","DOIUrl":"10.1016/j.jaim.2025.101196","url":null,"abstract":"<div><h3>Background</h3><div>Non-alcoholic Fatty Liver Disease (NAFLD) involves excessive fat build-up in the liver unrelated to alcohol use. This study aimed to evaluate the clinical efficacy and safety of Liv-Pro capsules, a formulation combining <em>Osbeckia octandra</em> and <em>Aloe vera</em>, in managing NAFLD. This is the first report of the clinical trial using this combination against NAFLD.</div></div><div><h3>Methods</h3><div>A randomized, double-blind, placebo-controlled clinical trial was conducted with 30 NAFLD patients from February 1, 2021 to March 31, 2023. Participants received either Liv-Pro or a placebo (two capsules once a day) for two months. Medical assessments at baseline, one month, and two months included liver function tests (ALT and AST), abdominal ultrasound scan, serum creatinine analysis, and lipid profile assessment. All patients were advised on lifestyle modifications.</div></div><div><h3>Results</h3><div>Liv-Pro significantly reduced ALT levels after one month (p = 0.049) and two months (p = 0.048) compared to baseline. AST levels also decreased significantly in the first (p = 0.047) and second months (p = 0.046), showing a consistent decline. Liv-Pro reduced total cholesterol, triglycerides, and Low-density lipoprotein (LDL) levels significantly after one and two months (p < 0.05) compared to baseline measurements. Abdominal ultrasound scans showed a significant decrease in hepatic fat content after two months (p = 0.020). Serum creatinine levels remained stable throughout the treatment period.</div></div><div><h3>Conclusion</h3><div>Liv-Pro was well-tolerated with no reported side effects, suggesting its potential as a safe and effective therapeutic option for NAFLD. Continuous administration of Liv-Pro is recommended for sustained efficacy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101196"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101258
Sanjeev Rastogi , Shashwat Rastogi
Urine retention is a common problem in elderly people. In male it is often associated with prostatic hypertrophy and can also be associated with hypo contractile bladder. Such functional disorders of bladder do not respond well to conventional medicine and the only respite is given by catheterization either in situ or intermittent as per the requirement. Besides social stigma, catheterization has its own accompanying problems leading to its poor acceptance. Newer approaches like electrical stimulation, Sacral neuro-modulation and stem cell therapy for this clinical condition are still in the process of development. Ayurveda earlier has reported to have successfully treated such cases to the extent of complete recovery. We present here a case of 83 year old male who was not able to pass the urine due to bladder hypo contractility and was on self-retaining catheter for about 2 years, got clinically cured with the help of Ayurveda interventions taken for about a year. A follow up of the case was done for another two years to find him well without any medication. This case endorses the worth of Ayurveda interventions in such cases and warrants a serious enquiry about such interventions to generate more robust evidences.
{"title":"Urine retention in elderly male due to hypo-contractile bladder treated successfully through Ayurveda – A Case Report","authors":"Sanjeev Rastogi , Shashwat Rastogi","doi":"10.1016/j.jaim.2025.101258","DOIUrl":"10.1016/j.jaim.2025.101258","url":null,"abstract":"<div><div>Urine retention is a common problem in elderly people. In male it is often associated with prostatic hypertrophy and can also be associated with hypo contractile bladder. Such functional disorders of bladder do not respond well to conventional medicine and the only respite is given by catheterization either in situ or intermittent as per the requirement. Besides social stigma, catheterization has its own accompanying problems leading to its poor acceptance. Newer approaches like electrical stimulation, Sacral neuro-modulation and stem cell therapy for this clinical condition are still in the process of development. Ayurveda earlier has reported to have successfully treated such cases to the extent of complete recovery. We present here a case of 83 year old male who was not able to pass the urine due to bladder hypo contractility and was on self-retaining catheter for about 2 years, got clinically cured with the help of Ayurveda interventions taken for about a year. A follow up of the case was done for another two years to find him well without any medication. This case endorses the worth of Ayurveda interventions in such cases and warrants a serious enquiry about such interventions to generate more robust evidences.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101258"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101219
Ekta Mishra, Shivam Sharma, Kashinath G. Metri
Major depressive disorder is a common mental disorder with a lifetime prevalence of 4.4 % worldwide. Cognitive dysfunction is a consequence of MDD. A 27-year-old female with MDD since 2015 experienced an acute MDD episode with anxiety, extreme sadness, poor memory, and impaired attention in July 2023 after discontinuation of anti-depressants. She was on anti-depressants since 2023, yet symptoms persisted. She enrolled in yoga therapy in January 2024. Yoga therapy consisted of a 60-min yoga session every day of the week for 12 weeks. She was followed up twice, on the 15th and 90th day. The selective and sustained attention, working memory and depressive symptoms were assessed using the Attention Network Test, Colour Stroop test, Corsi Block test, and the Beck Depression Inventory-II, respectively. There was marked improvement in selected and sustained attention and depressive symptoms but no improvement in working memory on the 90th day compared to baseline and 15th day. This case study concludes that yoga therapy as an add-on to the conventional treatment of MDD may enhance cognition and reduce depressive symptoms in patients with MDD who have a poor response to conventional anti-depressant treatment. This case study provides insights into the possible role of yoga in MDD patients who poorly respond to conventional anti-depressant therapy.
{"title":"Effect of yoga therapy as an add-on to conventional medicine in improving cognitive functions and depressive symptoms in major depressive disorder: A case report","authors":"Ekta Mishra, Shivam Sharma, Kashinath G. Metri","doi":"10.1016/j.jaim.2025.101219","DOIUrl":"10.1016/j.jaim.2025.101219","url":null,"abstract":"<div><div>Major depressive disorder is a common mental disorder with a lifetime prevalence of 4.4 % worldwide. Cognitive dysfunction is a consequence of MDD. A 27-year-old female with MDD since 2015 experienced an acute MDD episode with anxiety, extreme sadness, poor memory, and impaired attention in July 2023 after discontinuation of anti-depressants. She was on anti-depressants since 2023, yet symptoms persisted. She enrolled in yoga therapy in January 2024. Yoga therapy consisted of a 60-min yoga session every day of the week for 12 weeks. She was followed up twice, on the 15th and 90th day. The selective and sustained attention, working memory and depressive symptoms were assessed using the Attention Network Test, Colour Stroop test, Corsi Block test, and the Beck Depression Inventory-II, respectively. There was marked improvement in selected and sustained attention and depressive symptoms but no improvement in working memory on the 90th day compared to baseline and 15th day. This case study concludes that yoga therapy as an add-on to the conventional treatment of MDD may enhance cognition and reduce depressive symptoms in patients with MDD who have a poor response to conventional anti-depressant treatment. This case study provides insights into the possible role of yoga in MDD patients who poorly respond to conventional anti-depressant therapy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101219"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101222
A.M.H.S. Attanayake , U.M.G.D. De Silva , A. Upadhyay , A.K. Sahu , P.K. Perera
Stroke due to intracerebral hemorrhage is the most destructive subtype often causing disabilities in survivors. Early motor recovery, improving quality of life and improved social participation are the key aspects of stroke rehabilitation. Ayurveda describes stroke as Pakshaghata and categorized it as a Vata dominant disease.
This case reports the effect of Ayurveda and Sri Lankan traditional medicine in post stroke rehabilitation of a 60-year-old male, known case of diabetes and hypertension with recent left sided hemiplegia due to hemorrhage in the basal ganglia and hemorrhage in the lateral ventricle.
Following initial management at a modern facility for three weeks, the patient received Ayurveda and Sri Lankan traditional interventions for three months in addition to conventional treatment. Improvement was monitored using visual analogue scale, improvement in neurological and motor functions, clinical parameters, quality of life with stroke specific quality of life index, and life satisfaction questionnaire.
Significant improvement in motor functions, muscle tone, rigidity and hyperreflexia were observed. Patient's bladder-bowel control and functional abilities also improved leading to better quality of life. Better control of blood pressure and glucose levels was also observed indicating positive outcomes of integration of Ayurveda with conventional therapy in such cases. No adverse effects were observed during the observation period.
This case report suggests that Ayurveda and folklore medicine may play an important role in improving neuromuscular functions, quality of life and speedy rehabilitation of stroke patients.
{"title":"Role of Ayurveda and Sri Lankan traditional medicine in post hemorrhagic stroke rehabilitation - A Case Report","authors":"A.M.H.S. Attanayake , U.M.G.D. De Silva , A. Upadhyay , A.K. Sahu , P.K. Perera","doi":"10.1016/j.jaim.2025.101222","DOIUrl":"10.1016/j.jaim.2025.101222","url":null,"abstract":"<div><div>Stroke due to intracerebral hemorrhage is the most destructive subtype often causing disabilities in survivors. Early motor recovery, improving quality of life and improved social participation are the key aspects of stroke rehabilitation. Ayurveda describes stroke as Pakshaghata and categorized it as a Vata dominant disease.</div><div>This case reports the effect of Ayurveda and Sri Lankan traditional medicine in post stroke rehabilitation of a 60-year-old male, known case of diabetes and hypertension with recent left sided hemiplegia due to hemorrhage in the basal ganglia and hemorrhage in the lateral ventricle.</div><div>Following initial management at a modern facility for three weeks, the patient received Ayurveda and Sri Lankan traditional interventions for three months in addition to conventional treatment. Improvement was monitored using visual analogue scale, improvement in neurological and motor functions, clinical parameters, quality of life with stroke specific quality of life index, and life satisfaction questionnaire.</div><div>Significant improvement in motor functions, muscle tone, rigidity and hyperreflexia were observed. Patient's bladder-bowel control and functional abilities also improved leading to better quality of life. Better control of blood pressure and glucose levels was also observed indicating positive outcomes of integration of Ayurveda with conventional therapy in such cases. No adverse effects were observed during the observation period.</div><div>This case report suggests that Ayurveda and folklore medicine may play an important role in improving neuromuscular functions, quality of life and speedy rehabilitation of stroke patients.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101222"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jaim.2025.101239
Rajesh Kotecha , Deep Narayan Pandey
The rediscovery of Vrikshayurveda principles offers a holistic framework to address contemporary environmental challenges and support sustainability goals. This analysis provides three foundational principles—Resource Utilization and Regeneration, No Harm to Nature, and Resource Conservation—rooted in the Atharva Veda and integrates ancient wisdom with modern ecological science. Through an exploration of Vedic texts and contemporary literature, these principles are shown to align with regenerative agriculture, natural forest regeneration, and biodiversity conservation, offering practical, scalable, and cost-effective solutions. Their applications extend to urban forestry, regenerative agriculture, and ecosystem recovery, demonstrating the potential to enhance soil health, improve carbon sequestration, and facilitate community-based conservation efforts. Furthermore, this approach also highlights how ancient practices, such as water harvesting and agroforestry, can inform modern strategies to achieve global restoration targets, environmental management, urban greening, and human health promotion. Future research should examine how Vrikshayurveda principles, in conjunction with contemporary science, can systematically be integrated into contemporary conservation policies, bridging cultural heritage with scientific advancements to create resilient ecosystems and sustainable societies through nature-based solutions.
{"title":"Rediscovery of Vrikshayurveda: A nature-based vision for sustainability","authors":"Rajesh Kotecha , Deep Narayan Pandey","doi":"10.1016/j.jaim.2025.101239","DOIUrl":"10.1016/j.jaim.2025.101239","url":null,"abstract":"<div><div>The rediscovery of Vrikshayurveda principles offers a holistic framework to address contemporary environmental challenges and support sustainability goals. This analysis provides three foundational principles—Resource Utilization and Regeneration, No Harm to Nature, and Resource Conservation—rooted in the Atharva Veda and integrates ancient wisdom with modern ecological science. Through an exploration of Vedic texts and contemporary literature, these principles are shown to align with regenerative agriculture, natural forest regeneration, and biodiversity conservation, offering practical, scalable, and cost-effective solutions. Their applications extend to urban forestry, regenerative agriculture, and ecosystem recovery, demonstrating the potential to enhance soil health, improve carbon sequestration, and facilitate community-based conservation efforts. Furthermore, this approach also highlights how ancient practices, such as water harvesting and agroforestry, can inform modern strategies to achieve global restoration targets, environmental management, urban greening, and human health promotion. Future research should examine how Vrikshayurveda principles, in conjunction with contemporary science, can systematically be integrated into contemporary conservation policies, bridging cultural heritage with scientific advancements to create resilient ecosystems and sustainable societies through nature-based solutions.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101239"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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