Pub Date : 2019-03-11DOI: 10.4172/2155-952X-C1-112
pChara Simitzi, Richard Dayp
{"title":"Biodegradable microparticles with hierarchical topographical features influence mesenchymal stem cell behaviour","authors":"pChara Simitzi, Richard Dayp","doi":"10.4172/2155-952X-C1-112","DOIUrl":"https://doi.org/10.4172/2155-952X-C1-112","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84115002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-11DOI: 10.4172/2155-952X-C1-113
pHanin Bashirp
{"title":"Antimicrobial nano-fiber structures development to rejuvenate injured dura mater in brain surgery","authors":"pHanin Bashirp","doi":"10.4172/2155-952X-C1-113","DOIUrl":"https://doi.org/10.4172/2155-952X-C1-113","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85331416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-07DOI: 10.4172/2155-952X-C2-116
pMartin Schomberp
{"title":"Cellulase production with Penicillium verruculosum strain in lab and pilot scale","authors":"pMartin Schomberp","doi":"10.4172/2155-952X-C2-116","DOIUrl":"https://doi.org/10.4172/2155-952X-C2-116","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82045116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-07DOI: 10.4172/2155-952X-C2-115
Annele Sainio
{"title":"Human metaplastic breast carcinoma and decorin","authors":"Annele Sainio","doi":"10.4172/2155-952X-C2-115","DOIUrl":"https://doi.org/10.4172/2155-952X-C2-115","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83114156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-12DOI: 10.4172/2155-952x-c8-109
pDinah Weissmannp
Major depressive and bipolar disorders are leading causes of disability worldwide yet, many people remain undiagnosed or misdiagnosed or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms and currently, there is no molecular diagnostic test available. Identifying and validating blood biomarkers could provide a more accurate and objective means of diagnosis. Genetic and epigenetic events are involved in psychiatric aetiology, among them RNA editing modifications have been associated with inflammation and neuropsychiatric disorders. Adenosine to inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease. RNA editing is post-transcriptional process that leads to functional diversity of proteins. These marks form the molecular interface between the genome and the environment. Of particular interest is the RNA editing modification that occurs on the phosphodiesterase 8A gene located on chromosome 15q25.3, a genomic region that has recurrently been associated with early onset of major depressive disorder. ALCEDIAG???s test, EDITDIAG, identifies in blood specific signatures through the RNA editing modifications of patients in different pathological conditions such as a cohort of hepatitis C infected patients, treated with interferon alpha and ribavirin were followed during 16 weeks. This treatment is well known to trigger depression in 50% of patients. RNA editing modifications were measured each two weeks as well as clinical evaluations of depression (MINI). An algorithm was identified which allows to discriminate patients with depression from others with a high specificity and sensitivity; a cohort of depressed patients (n=163) was compared to controls (n=69). A specific RNA editing signature was identified in depressed patients. The test shows that RNA editing related blood biomarkers allow to stratify patients, characterizes psychiatric conditions and follows up the disease/treatment modifications along time. This test paves the way for a better management of psychiatric patients. Recent Publications 1. Weissmann D, Underwood M, Salvetat N, Cavarec L and Vincent L (2016) Region specific alterations of A-to-I RNA editin of serotonin 2c receptor in cortex of suicides with major depression. Translational Psychiatry 6(8):e878. 2. Van Der Laan S, Salvetat N, Weissmann D and Molina F (2017) Emerging RNA editing biomarkers will foster drug development. Drug Discovery Today 22(7):1056-1063. 3. Cavarec L, Vincent L, Le Borgne C, Plusquellec C and Ollivier N (2013) In Vitro screening for drug-induced depression and/or suicidal adverse effects: a new toxicogenomic assay based on CE-SSCP analysis of HTR2C mRNA editing in SHSY5Y cells. Neurotox Res. 23(1):49-62. 4. Cambon K, Dos-Santos Coura R, Groc L, Carbon A and Weissmann D (2010) Aggressive behavior during social interaction in mice is controlled by the modulation of
重度抑郁症和双相情感障碍是全世界致残的主要原因，然而，许多人仍未得到诊断或误诊或治疗无效。诊断依赖于对症状的临床评估，目前还没有可用的分子诊断测试。识别和验证血液生物标志物可以提供更准确和客观的诊断手段。遗传和表观遗传事件涉及精神病学病因学，其中RNA编辑修饰与炎症和神经精神疾病有关。腺苷到肌苷RNA编辑构成了一个生理细胞过程，通过调节健康和疾病中突触水平的蛋白质功能来翻译环境线索。RNA编辑是导致蛋白质功能多样性的转录后过程。这些标记形成了基因组和环境之间的分子界面。特别令人感兴趣的是发生在染色体15q25.3上的磷酸二酯酶8A基因上的RNA编辑修饰，这个基因组区域经常与早期发病的重度抑郁症有关。ALCEDIAG ? ?该公司的EDITDIAG测试通过RNA编辑修饰来识别不同病理状态患者的血液特异性特征，例如一组丙型肝炎感染患者，在16周内接受干扰素α和利巴韦林治疗。众所周知，这种治疗方法会导致50%的患者患上抑郁症。每两周测量一次RNA编辑修饰以及抑郁症的临床评估(MINI)。确定了一种算法，该算法可以以高特异性和敏感性区分抑郁症患者;一组抑郁症患者(n=163)与对照组(n=69)进行比较。在抑郁症患者中发现了一种特定的RNA编辑特征。该测试表明，RNA编辑相关的血液生物标志物允许对患者进行分层，表征精神疾病，并随时间跟踪疾病/治疗修改。这项试验为更好地管理精神病患者铺平了道路。最近的出版物魏思曼，陈晓明，陈晓明，等。(2016)重度抑郁自杀患者血清素2c受体A-to-I RNA编辑素的区域特异性改变。中华精神病学杂志，6(8):878。2. Van Der Laan S, Salvetat N, Weissmann D和Molina F(2017)新兴RNA编辑生物标志物将促进药物开发。药物发现今日22(7):1056-1063。3.Cavarec L, Vincent L, Le Borgne C, plusquelec C和Ollivier N (2013) SHSY5Y细胞中HTR2C mRNA编辑的一种新的毒性基因组学分析方法:体外筛选药物性抑郁和/或自杀不良反应。中华神经医学杂志，23(1):49-62。4. Cambon K, Dos-Santos Coura R, Groc L, Carbon A和Weissmann D(2010)小鼠社会交往中的攻击行为受前额叶皮层酪氨酸羟化酶表达的调节。神经科学171(3):840 - 51。
{"title":"Epitranscriptomic blood biomarkers to manage psychiatric disorders","authors":"pDinah Weissmannp","doi":"10.4172/2155-952x-c8-109","DOIUrl":"https://doi.org/10.4172/2155-952x-c8-109","url":null,"abstract":"Major depressive and bipolar disorders are leading causes of disability worldwide yet, many people remain undiagnosed or misdiagnosed or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms and currently, there is no molecular diagnostic test available. Identifying and validating blood biomarkers could provide a more accurate and objective means of diagnosis. Genetic and epigenetic events are involved in psychiatric aetiology, among them RNA editing modifications have been associated with inflammation and neuropsychiatric disorders. Adenosine to inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease. RNA editing is post-transcriptional process that leads to functional diversity of proteins. These marks form the molecular interface between the genome and the environment. Of particular interest is the RNA editing modification that occurs on the phosphodiesterase 8A gene located on chromosome 15q25.3, a genomic region that has recurrently been associated with early onset of major depressive disorder. ALCEDIAG???s test, EDITDIAG, identifies in blood specific signatures through the RNA editing modifications of patients in different pathological conditions such as a cohort of hepatitis C infected patients, treated with interferon alpha and ribavirin were followed during 16 weeks. This treatment is well known to trigger depression in 50% of patients. RNA editing modifications were measured each two weeks as well as clinical evaluations of depression (MINI). An algorithm was identified which allows to discriminate patients with depression from others with a high specificity and sensitivity; a cohort of depressed patients (n=163) was compared to controls (n=69). A specific RNA editing signature was identified in depressed patients. The test shows that RNA editing related blood biomarkers allow to stratify patients, characterizes psychiatric conditions and follows up the disease/treatment modifications along time. This test paves the way for a better management of psychiatric patients. Recent Publications 1. Weissmann D, Underwood M, Salvetat N, Cavarec L and Vincent L (2016) Region specific alterations of A-to-I RNA editin of serotonin 2c receptor in cortex of suicides with major depression. Translational Psychiatry 6(8):e878. 2. Van Der Laan S, Salvetat N, Weissmann D and Molina F (2017) Emerging RNA editing biomarkers will foster drug development. Drug Discovery Today 22(7):1056-1063. 3. Cavarec L, Vincent L, Le Borgne C, Plusquellec C and Ollivier N (2013) In Vitro screening for drug-induced depression and/or suicidal adverse effects: a new toxicogenomic assay based on CE-SSCP analysis of HTR2C mRNA editing in SHSY5Y cells. Neurotox Res. 23(1):49-62. 4. Cambon K, Dos-Santos Coura R, Groc L, Carbon A and Weissmann D (2010) Aggressive behavior during social interaction in mice is controlled by the modulation of","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84972714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-03DOI: 10.4172/2155-952X-C3-093
Nathan S Bryan
{"title":"Nitric oxide and heart disease: New discoveries and innovations in diagnostics and therapeutics","authors":"Nathan S Bryan","doi":"10.4172/2155-952X-C3-093","DOIUrl":"https://doi.org/10.4172/2155-952X-C3-093","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73367066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-14DOI: 10.4172/2155-952x-c1-087
Yongmei Zheng
{"title":"Bioinspired surfaces with gradient micro- and nanostructures and dynamic wettability","authors":"Yongmei Zheng","doi":"10.4172/2155-952x-c1-087","DOIUrl":"https://doi.org/10.4172/2155-952x-c1-087","url":null,"abstract":"","PeriodicalId":15156,"journal":{"name":"Journal of biotechnology & biomaterials","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80250213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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