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Average rotation matrices for converting scapula- and glenoid-based coordinate systems to ISB recommendations 将基于肩胛骨和关节的坐标系转换为ISB推荐坐标系的平均旋转矩阵。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jbiomech.2026.113219
Florent Moissenet , Benjamin Michaud , Pierre Puchaud , Nicola Hagemeister , Mickaël Begon , Nicolas Holzer
Defining bone-embedded local coordinate systems (LCSs) is fundamental in shoulder biomechanics, yet multiple scapular LCSs exist, hindering data comparison. Although the International Society of Biomechanics (ISB) has published recommendations, alternative definitions based on distinct anatomical landmarks remain often used. To address these inconsistencies, average rotation matrices were recently proposed to convert between the three most common scapular LCSs, thereby facilitating comparison, merging, and interoperability between datasets. Building upon this, we have extended the approach to 11 scapular LCSs reported in the literature, including scapula- and glenoid-based systems. Using statistical shape models derived from 80 participants (asymptomatic and pathological shoulders), 1000 scapulae were generated to quantify geometric transformations between LCSs. Average rotation matrices were computed for each alternative system relative to the ISB-recommended LCS, and accuracy was assessed using helical angles. The application of the average rotation matrices substantially reduced the maximal discrepancies between LCSs, from 21.9° to 5.2°. Scapula-based systems exhibited lower discrepancies than glenoid-based ones, reflecting greater morphological variability in the glenoid region. Comparisons with previously published matrices showed minimal differences (<3°), supporting the robustness of the approach across various datasets and population. These findings confirm that average rotation matrices provide a reliable means of harmonising scapular kinematic data across studies, even if experimenters initially chose a different LCS. This work offers a simple framework, for bridging existing scapular kinematic datasets and promoting interoperability datasets in shoulder biomechanics research.
定义骨嵌入局部坐标系统(lcs)是肩部生物力学的基础,但存在多个肩胛骨lcs,阻碍了数据比较。尽管国际生物力学学会(ISB)已经发表了建议,但基于不同解剖标志的替代定义仍然经常被使用。为了解决这些不一致,最近提出了平均旋转矩阵在三种最常见的肩胛骨lcs之间进行转换,从而促进数据集之间的比较,合并和互操作性。在此基础上,我们将入路扩展到文献中报道的11例肩胛骨lcs,包括肩胛骨和肩关节为基础的系统。使用来自80名参与者(无症状肩部和病理性肩部)的统计形状模型,生成1000个肩胛骨,以量化lcs之间的几何转换。相对于isb推荐的LCS,计算每个备选系统的平均旋转矩阵,并使用螺旋角评估准确性。平均旋转矩阵的应用大大减少了lcs之间的最大差异,从21.9°降至5.2°。肩胛骨为基础的系统比肩胛为基础的系统表现出更低的差异,反映了肩胛区域更大的形态变异。与先前发表的矩阵比较显示差异很小(
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引用次数: 0
The use of residual lower limb –prosthetic socket interface pressure measurements to inform clinical decisions: A systematic review 残肢-义肢窝界面压力测量用于临床决策:一项系统综述。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-01-25 DOI: 10.1016/j.jbiomech.2026.113187
Lucy Armitage , Kenny Cho , Tawnee L. Sparling , Todd Sleeman , Gursel Alici , Manish Sreenivasa
This systematic review aims to synthesise and consolidate existing knowledge on the relationship between socket interface pressure measurement and outcome measures related to clinical parameters of socket comfort in lower-limb prosthetic sockets. A search of Scopus, Web of Science, MEDLINE, CINAHL, Cochrane database of systematic reviews and IEEE Xplore was performed up to 2nd August 2024. A total of 19 studies were included in the data extraction and quality assessment process. Most studies were moderate to high quality. Extracted data included a variety of sensing systems, predominantly on male subjects with transtibial amputation, measuring normal forces or pressure. Loads were associated with comfort, discomfort, satisfaction, pain onset or pain tolerance, tissue safety and changes to satisfaction over time. There were no studies reporting any of these outcomes for people with impaired sensation or phantom limb pain. Although, there was no consistent identifiable threshold associated with a comfort or discomfort condition for any region or activity between studies, measurements at some bony regions during dynamic or activity associated with higher interface loading allowed differentiation between comfortable and uncomfortable socket conditions across studies. The synthesis of the reported pressure measurements could be a starting point for the iterative process of developing tissue-safe pressure thresholds or ranges for use in long term socket fit monitoring or to assist clinicians and prosthesis users in defining socket fit and comfort.
本系统综述的目的是综合和巩固现有的关于下肢假肢关节窝界面压力测量与关节窝舒适临床参数相关结果测量之间关系的知识。检索截止到2024年8月2日的Scopus、Web of Science、MEDLINE、CINAHL、Cochrane系统综述数据库和IEEE explore。数据提取和质量评估过程共纳入了19项研究。大多数研究都是中等到高质量的。提取的数据包括各种传感系统,主要是对男性受试者进行胫骨截肢,测量正常的力或压力。负荷与舒适、不适、满意度、疼痛发作或疼痛耐受性、组织安全性以及满意度随时间的变化有关。没有研究报告这些结果适用于感觉受损或幻肢痛的人。尽管在不同的研究中,没有与任何区域或活动的舒适或不舒服状况相关的一致的可识别阈值,但在与较高界面负载相关的动态或活动期间,对某些骨骼区域的测量可以区分不同研究中舒适和不舒服的窝腔状况。综合报告的压力测量值可以作为开发组织安全压力阈值或范围的迭代过程的起点,用于长期的套管配合监测,或协助临床医生和假体使用者定义套管配合度和舒适度。
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引用次数: 0
Running with an exotendon reduces compressive knee contact force 使用外肌腱跑步可以减少膝关节的压缩接触力。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jbiomech.2026.113217
Jon Stingel , Nicos Haralabidis , Jennifer Hicks , Scott Uhlrich , Scott Delp
An exotendon—a spring that couples the legs when attached to a runner’s shoes—reduces the energetic cost of running, but the effects on joint contact forces are unknown. This study examined whether running with an exotendon alters the forces in the hip, knee and ankle. We used muscle-driven simulations of experimental data to compute compressive and shear contact forces at the hip, knee, and ankle joints for seven participants running at 2.7 m/s with and without an exotendon. We found that runners using the exotendon experienced a 8.4% reduction in peak knee compressive contact force (1.0 ± 0.7 BW; P = 0.026), and no change in the peak knee shear contact force. The primary contributor to this reduction was lower forces in the quadriceps muscles, which decreased their contribution to peak knee compressive contact force by 12.2% (−0.8 ± 0.7 BW; P = 0.018). We observed no change in the peak compressive or shear contact forces in the hip or ankle joints. Though the exotendon was not originally designed to reduce joint forces, our findings highlight the ability of this simple device to make changes to gait that reduce both energetic cost and compressive knee force.
外伸肌腱——一种连接在跑步者鞋子上的弹簧——可以减少跑步时的能量消耗,但对关节接触力的影响尚不清楚。这项研究考察了带外肌腱跑步是否会改变臀部、膝盖和脚踝的受力。我们使用肌肉驱动的模拟实验数据来计算7名参与者在有或没有外肌腱的情况下以2.7 m/s的速度跑步时,髋关节、膝关节和踝关节处的压缩和剪切接触力。我们发现,使用外肌腱的跑步者膝盖峰值压缩接触力降低了8.4%(1.0±0.7 BW; P = 0.026),而膝盖峰值剪切接触力没有变化。这种减少的主要原因是股四头肌的力量较低,使其对峰值膝关节压缩接触力的贡献降低了12.2%(-0.8±0.7 BW; P = 0.018)。我们观察到髋关节或踝关节的峰值压缩或剪切接触力没有变化。虽然外肌腱最初并不是为了减少关节力而设计的,但我们的研究结果强调了这种简单装置改变步态的能力,从而降低了能量消耗和膝关节压缩力。
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引用次数: 0
Dynamic regulation of Lower-Limb joint loading during Foot-Abducted landing in wide Lunge: An analysis of muscle synergy and neuromuscular activation patterns 下肢关节负荷的动态调节在足外蹬大箭步着地:肌肉协同和神经肌肉激活模式的分析。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.jbiomech.2026.113231
Yanlong Zhang , Yanyu Yin , Xiao Yu , Minghe Sun , Gengchao Bi , Si Chen
This study compares the relative contribution of knee joint medial and lateral compartmental loading, muscle synergy, and activation characteristics between two types of wide-lunge landing strategies to reveal the neuromuscular mechanisms by which foot-abducted landings reduce injury risk. Twenty male badminton players performed the lunge with two foot orientations: heel-to-second metatarsal (foot-forward) and 20° foot abduction (foot-abducted). The foot-abducted landing significantly reduced medial compartment peak shear force and pressure contributions from the semitendinosus, vastus medialis, and vastus lateralis (P < 0.05). It also decreased lateral compartment moments and muscle contributions from the biceps femoris, rectus femoris, and medial gastrocnemius (P < 0.05). Among the four identified muscle synergies, Syn1 was primarily active before landing. In foot-abducted landings, Syn2 exhibited higher activation of the vastus medialis and vastus lateralis (P < 0.05), while Syn3 showed greater gastrocnemius involvement (P < 0.05). Additionally, the co-activation index indicated higher gastrocnemius activity in foot-abducted landings (P < 0.05). These findings suggest that landing with foot abduction and initial lateral heel contact realigns force vectors, reducing knee joint loading. This strategy promotes a shift from single-joint control to a multi-joint kinetic-chain synergy, demonstrating a neuromuscular pattern associated with lower injury risk.
本研究比较了两种大弓步着地策略之间膝关节内侧和外侧室室负荷、肌肉协同作用和激活特征的相对贡献,以揭示足部外旋着地降低损伤风险的神经肌肉机制。20名男子羽毛球运动员用两种脚的方向进行弓步:脚跟到第二跖(脚向前)和脚外展20°(脚外展)。脚外展着地显著降低了内侧筋室峰值剪切力和来自半腱肌、股内侧肌和股外侧肌的压力贡献(P
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引用次数: 0
Quantifying differences in high-pressure region mapping between dynamic in-shoe and barefoot plantar pressure in diabetic subjects 糖尿病患者动态鞋内足底压力与赤脚足底压力之间高压区映射的量化差异。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-08 DOI: 10.1016/j.jbiomech.2026.113201
Dylan Heino , Scott Telfer , Avocet Nagle-Christensen , William R. Ledoux , Brittney C. Muir
Foot ulceration is a serious complication of diabetes, often linked to elevated forefoot pressures during walking. Custom accommodative insoles reduce peak plantar pressures, with greater reductions achieved when dynamic pressure data informs design. While in-shoe and barefoot data are used separately to design insoles, their agreement in pressure distribution and high-pressure region location has not been evaluated. This study compares pressure distribution and high-pressure region mapping between in-shoe and barefoot data.
In-shoe and barefoot pressures were recorded during walking for 25 feet from 16 individuals with high forefoot pressures. High-pressure regions were masked, grouped, and labeled by anatomical region. In-shoe and barefoot pressure maps were averaged over trials and overlaid, and peak pressure and contact area were calculated for all high-pressure regions. For matched regions, centroid locations were compared.
In-shoe high-pressure regions (>200 kPa) were typically observed in similar locations to barefoot walking, while barefoot maps often identified additional regions (>450 kPa) in the toes and lateral forefoot. For in-shoe data, these regions had lower peak pressures and larger contact areas. Matched regions’ centroid positions differed by 0.23–0.60 cm.
Key loading areas were consistent between systems, though unmatched regions were common, particularly in barefoot data, reflecting greater sensitivity to localized pressures. Barefoot data may overestimate high-risk regions that do not display elevated in-shoe pressures. Basing offloading insole design on threshold-based barefoot high-pressure regions could reduce specificity and limit pressure reduction for in-shoe high-pressure regions. These findings have potential implications for streamlining clinical workflows during pressure-informed insole design.
足部溃疡是糖尿病的严重并发症,通常与行走时前脚压力升高有关。定制调节鞋垫减少峰值足底压力,更大的减少实现时,动态压力数据通知设计。虽然鞋内和赤脚数据分别用于设计鞋垫,但它们在压力分布和高压区域位置上的一致性尚未得到评估。本研究比较了鞋内和赤脚数据的压力分布和高压区域映射。记录了16名前足压力高的人在行走25英尺时的鞋内和赤脚压力。高压区被掩盖,分组,并按解剖区域标记。在试验中取鞋内和赤脚压力图的平均值并叠加,并计算所有高压区域的峰值压力和接触面积。对于匹配的区域,比较质心位置。鞋内高压区(bb1 ~ 200千帕)通常在与赤脚行走相似的位置观察到,而赤脚地图通常在脚趾和前外侧发现额外的区域(bb1 ~ 450千帕)。对于鞋内数据,这些区域具有较低的峰值压力和较大的接触面积。匹配区域的质心位置相差0.23 ~ 0.60 cm。系统之间的关键加载区域是一致的,尽管不匹配的区域很常见,特别是在赤脚数据中,反映了对局部压力的更大敏感性。赤脚数据可能高估了没有显示鞋内压力升高的高风险区域。基于阈值的赤脚高压区设计卸载鞋垫,降低了鞋内高压区的特异性,限制了鞋内高压区的减压。这些发现对于在压力知情的鞋垫设计过程中简化临床工作流程具有潜在的意义。
{"title":"Quantifying differences in high-pressure region mapping between dynamic in-shoe and barefoot plantar pressure in diabetic subjects","authors":"Dylan Heino ,&nbsp;Scott Telfer ,&nbsp;Avocet Nagle-Christensen ,&nbsp;William R. Ledoux ,&nbsp;Brittney C. Muir","doi":"10.1016/j.jbiomech.2026.113201","DOIUrl":"10.1016/j.jbiomech.2026.113201","url":null,"abstract":"<div><div>Foot ulceration is a serious complication of diabetes, often linked to elevated forefoot pressures during walking. Custom accommodative insoles reduce peak plantar pressures, with greater reductions achieved when dynamic pressure data informs design. While in-shoe and barefoot data are used separately to design insoles, their agreement in pressure distribution and high-pressure region location has not been evaluated. This study compares pressure distribution and high-pressure region mapping between in-shoe and barefoot data.</div><div>In-shoe and barefoot pressures were recorded during walking for 25 feet from 16 individuals with high forefoot pressures. High-pressure regions were masked, grouped, and labeled by anatomical region. In-shoe and barefoot pressure maps were averaged over trials and overlaid, and peak pressure and contact area were calculated for all high-pressure regions. For matched regions, centroid locations were compared.</div><div>In-shoe high-pressure regions (&gt;200 kPa) were typically observed in similar locations to barefoot walking, while barefoot maps often identified additional regions (&gt;450 kPa) in the toes and lateral forefoot. For in-shoe data, these regions had lower peak pressures and larger contact areas. Matched regions’ centroid positions differed by 0.23–0.60 cm.</div><div>Key loading areas were consistent between systems, though unmatched regions were common, particularly in barefoot data, reflecting greater sensitivity to localized pressures. Barefoot data may overestimate high-risk regions that do not display elevated in-shoe pressures. Basing offloading insole design on threshold-based barefoot high-pressure regions could reduce specificity and limit pressure reduction for in-shoe high-pressure regions. These findings have potential implications for streamlining clinical workflows during pressure-informed insole design.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113201"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of lower limb kinematic characteristics in stroke patients on gait speed mediated by paretic side propulsive force 脑卒中患者下肢运动特征对瘫侧推进力介导的步态速度的影响。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1016/j.jbiomech.2026.113220
Haruna Ukigai , Yuichiro Hosoi , Takayuki Kamimoto , Junsuke Ito , Arisa Kawabata , Kohsuke Okada , Kohshiro Haruyama , Tetsuya Tsuji , Michiyuki Kawakami
The relationships among gait speed, paretic side propulsive force (PPF), and kinematic characteristics in stroke patients remain unclear. This study retrospectively analyzed data from 109 post-stroke patients to identify kinematic characteristics influencing gait speed mediated by PPF. Motion capture system was used for measuring ground walking, and hip, knee, and ankle joint angle during stance phase of paretic side were extracted. The joint angle data were classified into four phases (the initial double-support (Phase 1), the first and second 50% of the single-leg stance (Phase 2, Phase 3), the second double-support (Phase 4)), and average angle of the time series for each phase was calculated (kinematic variables). Comfortable gait speed (CGS) and PPF were also averaged. Statistical analysis first performed correlation analysis between CGS, PPF and kinematic variables. Next, mediation analysis was conducted using kinematic variables as independent variables, CGS as dependent variable, and PPF as mediating variable. Correlation analysis revealed that the kinematic variables of hip and knee joints in all phases, and ankle joint in Phase 3, showed significant correlations with CGS and PPF. For mediation analysis, the mediation model with only indirect effects significant was established for the following variables: hip extension (Total Effect (TE) =  − 0.007, p = 0.018), knee flexion (TE = 0.010, p < 0.01), and ankle dorsiflexion (TE = 0.013, p < 0.01) in Phases 3 and hip extension in Phase 4 (TE =  − 0.011, p < 0.01). These four kinematic variables were each found to influence gait speed mediated by PPF. In gait intervention, focusing on these joint movements during mid-to-late stance phase is important.
脑卒中患者的步态速度、麻痹侧推进力(PPF)和运动学特征之间的关系尚不清楚。本研究回顾性分析了109例脑卒中后患者的数据,以确定PPF介导的影响步态速度的运动学特征。采用运动捕捉系统测量地面行走,提取瘫侧站立阶段的髋关节、膝关节和踝关节角度。将关节角度数据分为4个阶段(初始双支撑阶段(Phase 1)、单腿站立的第一、第二个50%阶段(Phase 2、Phase 3)、第二次双支撑阶段(Phase 4)),并计算各阶段时间序列的平均角度(运动学变量)。舒适步态速度(CGS)和PPF也是平均的。统计分析首先对CGS、PPF与运动学变量进行相关性分析。其次,以运动学变量为自变量,CGS为因变量,PPF为中介变量进行中介分析。相关分析显示,各阶段髋关节、膝关节和第3阶段踝关节的运动学变量与CGS和PPF呈显著相关。为了进行中介分析,我们对以下变量建立了仅间接影响显著的中介模型:髋部伸展(总效应(Total Effect, TE) = - 0.007, p = 0.018),膝关节屈曲(TE = 0.010, p
{"title":"The influence of lower limb kinematic characteristics in stroke patients on gait speed mediated by paretic side propulsive force","authors":"Haruna Ukigai ,&nbsp;Yuichiro Hosoi ,&nbsp;Takayuki Kamimoto ,&nbsp;Junsuke Ito ,&nbsp;Arisa Kawabata ,&nbsp;Kohsuke Okada ,&nbsp;Kohshiro Haruyama ,&nbsp;Tetsuya Tsuji ,&nbsp;Michiyuki Kawakami","doi":"10.1016/j.jbiomech.2026.113220","DOIUrl":"10.1016/j.jbiomech.2026.113220","url":null,"abstract":"<div><div>The relationships among gait speed, paretic side propulsive force (PPF), and kinematic characteristics in stroke patients remain unclear. This study retrospectively analyzed data from 109 post-stroke patients to identify kinematic characteristics influencing gait speed mediated by PPF. Motion capture system was used for measuring ground walking, and hip, knee, and ankle joint angle during stance phase of paretic side were extracted. The joint angle data were classified into four phases (the initial double-support (Phase 1), the first and second 50% of the single-leg stance (Phase 2, Phase 3), the second double-support (Phase 4)), and average angle of the time series for each phase was calculated (kinematic variables). Comfortable gait speed (CGS) and PPF were also averaged. Statistical analysis first performed correlation analysis between CGS, PPF and kinematic variables. Next, mediation analysis was conducted using kinematic variables as independent variables, CGS as dependent variable, and PPF as mediating variable. Correlation analysis revealed that the kinematic variables of hip and knee joints in all phases, and ankle joint in Phase 3, showed significant correlations with CGS and PPF. For mediation analysis, the mediation model with only indirect effects significant was established for the following variables: hip extension (Total Effect (TE) =  − 0.007, p = 0.018), knee flexion (TE = 0.010, p &lt; 0.01), and ankle dorsiflexion (TE = 0.013, p &lt; 0.01) in Phases 3 and hip extension in Phase 4 (TE =  − 0.011, p &lt; 0.01). These four kinematic variables were each found to influence gait speed mediated by PPF. In gait intervention, focusing on these joint movements during mid-to-late stance phase is important.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113220"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “The impact of backpack load on adolescent stair descent safety and injury risk” [J. Biomech. 166 (2024) 112029] “背包载荷对青少年下楼梯安全及伤害风险的影响”[J]。生物医学学报,2016,32(2):1158 - 1158。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jbiomech.2026.113215
Zijun Lu, Chuangui Mao, Yuanyuan Tan, Tao Liu, Xinglu Li, Zhengao Li, Wenfei Zhu, Yuliang Sun
This study investigates the impact of increasing backpack load on the gait of adolescents during stair descent. Sixteen healthy male students (age = 12.9 ± 0.6 years) were required to descend the stairs in 4 loaded conditions. The kinematic, kinetic, and EMG data were collected synchronously and gait parameters, especially indicators of balance control, were analyzed. The posterior tilt angles (COM-COP IA in the sagittal plane) (0%–42%, 48%–53%, 58%–91%, p < 0.01), trunk anterior tilt angles (9–33%, 51–65%, p < 0.01), and CV of stride length (p < 0.01) increased with the backpack load. The COM-Step edge separation decreased with the increased backload (p < 0.01). In addition, the hip flexion torque (25–40%, 45–51%, p < 0.01), the rectus femoris activation, and the hip stiffness increased significantly as the load up to 15% Body Weight (BW)and 20% BW. The increasing backpack load may affect adolescent’s stair descent gait. Especially as the load was up to 15% BW, the adolescents’ bodies tended to tilt backwards relative to the support foot during the single stance phase. They may activate the hip flexors and tilt forward the trunk to recover from the balance perturbation, which was associated with increased hip flexion torques. This adjustment was more pronounced with the increasing backpack load. However, excessive forward flexion may increase the risk of forward falls. The boundaries of adjustment need further research in the future. Findings from this study provide baseline information on the intrinsic mechanisms of balance control during stair descent.
本研究探讨背包负重增加对青少年下楼梯时步态的影响。16名健康男学生(年龄= 12.9±0.6岁)被要求在4种负荷条件下下楼梯。同步采集运动学、动力学和肌电图数据,分析步态参数,特别是平衡控制指标。后倾斜角度(COM-COP IA在矢状面)(0%-42%,48%-53%,58%-91%,p
{"title":"Corrigendum to “The impact of backpack load on adolescent stair descent safety and injury risk” [J. Biomech. 166 (2024) 112029]","authors":"Zijun Lu,&nbsp;Chuangui Mao,&nbsp;Yuanyuan Tan,&nbsp;Tao Liu,&nbsp;Xinglu Li,&nbsp;Zhengao Li,&nbsp;Wenfei Zhu,&nbsp;Yuliang Sun","doi":"10.1016/j.jbiomech.2026.113215","DOIUrl":"10.1016/j.jbiomech.2026.113215","url":null,"abstract":"<div><div>This study investigates the impact of increasing backpack load on the gait of adolescents during stair descent. Sixteen healthy male students (age = 12.9 ± 0.6 years) were required to descend the stairs in 4 loaded conditions. The kinematic, kinetic, and EMG data were collected synchronously and gait parameters, especially indicators of balance control, were analyzed. The posterior tilt angles (COM-COP IA in the sagittal plane) (0%–42%, 48%–53%, 58%–91%, p &lt; 0.01), trunk anterior tilt angles (9–33%, 51–65%, p &lt; 0.01), and CV of stride length (p &lt; 0.01) increased with the backpack load. The COM-Step edge separation decreased with the increased backload (p &lt; 0.01). In addition, the hip flexion torque (25–40%, 45–51%, p &lt; 0.01), the rectus femoris activation, and the hip stiffness increased significantly as the load up to 15% Body Weight (BW)and 20% BW. The increasing backpack load may affect adolescent’s stair descent gait. Especially as the load was up to 15% BW, the adolescents’ bodies tended to tilt backwards relative to the support foot during the single stance phase. They may activate the hip flexors and tilt forward the trunk to recover from the balance perturbation, which was associated with increased hip flexion torques. This adjustment was more pronounced with the increasing backpack load. However, excessive forward flexion may increase the risk of forward falls. The boundaries of adjustment need further research in the future. Findings from this study provide baseline information on the intrinsic mechanisms of balance control during stair descent.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113215"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal stem cells differentiate dynamic from static load through variable regulation of the Hippo pathway 间充质干细胞通过Hippo通路的可变调节从静态负荷分化为动态负荷。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-21 DOI: 10.1016/j.jbiomech.2026.113228
Zhihui Xie , Buer Sen , Nina Nikitina , Sean Howard , Maya Styner , Clinton Rubin , Gunes Uzer , Janet Rubin
The mechanical environment of a cell, which profoundly influences cell behaviors, includes loading parameters such as magnitude, rate cycle number and duration. Time-varying, or dynamic, levels of load are generally associated with anabolic responses, while time invariant, or static, forces often increase catabolic pathophysiology. How cells differentiate between static and dynamic loading parameters is unclear. In mesenchymal stem cells (MSC), we found that static strain (SS) increased nuclear YAP at 3 h, whereas 200 cycles of dynamic strain (DS) did not. Differences in nuclear YAP were directed by phosphorylation of Hippo enzymes: SS promoted association of PP2Ac dephosphorylase with nuclear MST1/2. In contrast, DS activated Hippo signaling with phosphorylation of MST1/2 and YAP. Actin remodeling was differentially affected by DS and SS: DS generated thicker fibers with greater cross-sectional area and enhanced parallel alignment. In contrast, static strain reinforced the existing isotropic actin network by increasing fiber density and focal adhesion count. DS induced actin remodeling was associated with phosphorylation of both LATS1/2 and AMOT, which binds both actin and nuclear MST1/2. When LATS1/2 was inhibited, or AMOT was knocked down, nuclear PP2Ac increased and YAP was dephosphorylated. This suggests that DS induced actin remodeling provokes release of phosphorylated AMOT from actin binding sites, while SS induced actin reinforcement sequesters AMOT. In sum, our data shows that MSC are equipped to differentiate between load components, resulting in nuanced mechanical effects on the Hippo pathway.
电池的力学环境包括加载参数,如强度、速率周期数和持续时间等,对电池的行为有深远的影响。时变或动态的负荷水平通常与合成代谢反应有关,而时不变或静态的力通常会增加分解代谢病理生理。细胞如何区分静态和动态加载参数尚不清楚。在间充质干细胞(MSC)中,我们发现静态菌株(SS)在3 h时增加了核YAP,而200个周期的动态菌株(DS)则没有。核YAP的差异受Hippo酶磷酸化的影响:SS促进PP2Ac去磷酸化酶与核MST1/2的关联。相反,DS通过磷酸化MST1/2和YAP激活Hippo信号。DS和SS对肌动蛋白重塑的影响不同:DS产生的纤维更粗,横截面积更大,平行排列增强。相比之下,静态应变通过增加纤维密度和焦点粘附数来增强现有的各向同性肌动蛋白网络。DS诱导的肌动蛋白重塑与LATS1/2和AMOT的磷酸化有关,AMOT结合肌动蛋白和核MST1/2。当LATS1/2被抑制或AMOT被敲除时,细胞核PP2Ac增加,YAP去磷酸化。这表明DS诱导的肌动蛋白重塑激发了肌动蛋白结合位点磷酸化AMOT的释放,而SS诱导的肌动蛋白强化则隔离了AMOT。总之,我们的数据表明MSC能够区分负载成分,从而对Hippo通路产生细微的机械影响。
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引用次数: 0
Effects of infraglottal implantation on voice production in type I thyroplasty: a computational study 喉内植入对I型甲状腺成形术中声音产生的影响:一项计算研究。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.jbiomech.2026.113234
Weili Jiang , Charles Farbos de Luzan , Liran Oren , Ephraim Gutmark , Xudong Zheng , Qian Xue
Type I thyroplasty (TT1) is one of the primary phonosurgical interventions for unilateral vocal fold paralysis. This study investigated the effects of infraglottal implant placement in TT1 on voice production using numerical simulations. The laryngeal and implant geometries were reconstructed from computed tomography scan of a canine larynx with a hand-carved Silastic implant. Fluid–structure interaction simulations, coupling the continuum finite element vocal fold and implant models with a one-dimensional Bernoulli-based glottal flow model, were conducted to evaluate vocal fold vibration across a range of implant stiffnesses, insertion depths, and vertical positions. Effects of implant parameters on pre-phonatory shape and stiffness, glottal flow and vocal fold dynamics and acoustic outcome have been analyzed. The results revealed that infraglottal implants can enhance both sound pressure level (SPL) and vocal efficiency (VE) when the insertion depth exceeds a certain threshold. The observed enhancement in SPL and VE was attributed to an increased vertical stiffness gradient in the vocal folds induced by the inferior implant, which leads to greater force asymmetry between vocal folds opening and closing, thereby promoting more effective energy transfer from the glottal airflow to the vocal folds. The result is larger vocal fold vibrations, which leads to a larger SPL and may also contribute to the improved VE. The current simulation is based on the simulation of one single canine larynx. Future studies incorporating more subjects would help to generalize the current findings.
I型甲状腺成形术(TT1)是单侧声带麻痹的主要声音外科干预措施之一。本研究采用数值模拟的方法研究了TT1中颏下植入物对声音产生的影响。用手工雕刻的硅胶植入物重建了犬喉部的计算机断层扫描和植入物的几何形状。流体-结构相互作用模拟,将连续体有限元声带和种植体模型与一维伯努利声门流动模型耦合,以评估种植体刚度、插入深度和垂直位置范围内的声带振动。分析了种植体参数对发声前形状和刚度、声门流动和声带动力学以及声学效果的影响。结果表明,当植入深度超过一定阈值时,声压级(SPL)和发声效率(VE)均有提高。所观察到的声压级和声压级的增强是由于下部植入物引起声带垂直刚度梯度的增加,导致声带打开和关闭之间的力不对称更大,从而促进声门气流更有效地将能量传递到声带。结果是更大的声带振动,导致更大的声压级,也可能有助于改善VE。目前的模拟是基于对单个犬喉的模拟。纳入更多研究对象的未来研究将有助于概括目前的发现。
{"title":"Effects of infraglottal implantation on voice production in type I thyroplasty: a computational study","authors":"Weili Jiang ,&nbsp;Charles Farbos de Luzan ,&nbsp;Liran Oren ,&nbsp;Ephraim Gutmark ,&nbsp;Xudong Zheng ,&nbsp;Qian Xue","doi":"10.1016/j.jbiomech.2026.113234","DOIUrl":"10.1016/j.jbiomech.2026.113234","url":null,"abstract":"<div><div>Type I thyroplasty (TT1) is one of the primary phonosurgical interventions for unilateral vocal fold paralysis. This study investigated the effects of infraglottal implant placement in TT1 on voice production using numerical simulations. The laryngeal and implant geometries were reconstructed from computed tomography scan of a canine larynx with a hand-carved Silastic implant. Fluid–structure interaction simulations, coupling the continuum finite element vocal fold and implant models with a one-dimensional Bernoulli-based glottal flow model, were conducted to evaluate vocal fold vibration across a range of implant stiffnesses, insertion depths, and vertical positions. Effects of implant parameters on pre-phonatory shape and stiffness, glottal flow and vocal fold dynamics and acoustic outcome have been analyzed. The results revealed that infraglottal implants can enhance both sound pressure level (SPL) and vocal efficiency (VE) when the insertion depth exceeds a certain threshold. The observed enhancement in SPL and VE was attributed to an increased vertical stiffness gradient in the vocal folds induced by the inferior implant, which leads to greater force asymmetry between vocal folds opening and closing, thereby promoting more effective energy transfer from the glottal airflow to the vocal folds. The result is larger vocal fold vibrations, which leads to a larger SPL and may also contribute to the improved VE. The current simulation is based on the simulation of one single canine larynx. Future studies incorporating more subjects would help to generalize the current findings.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113234"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential mechanical behaviour of superficial and deep aponeurosis and tendon during in situ cyclic contractions of rabbit medial gastrocnemius muscle 兔内侧腓肠肌原位循环收缩时浅、深腱膜和肌腱的不同力学行为。
IF 2.4 3区 医学 Q3 BIOPHYSICS Pub Date : 2026-04-01 Epub Date: 2026-02-07 DOI: 10.1016/j.jbiomech.2026.113212
Stephanie A. Ross, Christine Waters-Banker, Andrew Sawatsky, Timothy R. Leonard, Walter Herzog
Aponeuroses are sheet-like extensions of tendon that transmit forces from muscle fascicles but experience more complex and heterogeneous loading than tendons. Despite this, most muscle models treat tendon and aponeurosis as a single, uniform elastic element in series with muscle. In this study, we examined strains of the superficial and deep aponeurosis and distal tendon of the rabbit medial gastrocnemius in situ under dynamic, physiologically relevant cyclic contractions. We found that, unlike tendon, aponeurosis did not exhibit strain patterns proportional to muscle force. Instead, both aponeuroses showed peak strain early in the activation phase and remained largely constant length during subsequent muscle shortening or lengthening, despite changes in force and belly length. These patterns were absent during passive cycles, indicating context-dependent behaviour of the aponeuroses. The superficial aponeurosis showed considerable variability in strain patterns across animals, particularly during active shortening, consistent with previous in vivo measures. Our findings challenge the assumption that aponeurosis and tendon function as a single series elastic element. Instead, aponeurosis exhibits distinct mechanical behaviour due to its complex structure and loading from the underlying muscle tissue. These results emphasize the need for muscle models that represent aponeurosis and tendon as separate structures, reflecting their unique mechanical behaviours and roles during contraction.
腱膜是腱的片状延伸,传递来自肌束的力,但比肌腱承受更复杂和不均匀的负荷。尽管如此,大多数肌肉模型将肌腱和腱膜视为与肌肉串联的单一,均匀的弹性元件。在这项研究中,我们检查了兔内侧腓肠肌在动态、生理相关的循环收缩下的浅、深腱膜和远端肌腱的张力。我们发现,与肌腱不同,腱膜不表现出与肌肉力量成比例的应变模式。相反,两种腱膜在激活阶段早期都表现出最大的张力,并且在随后的肌肉缩短或延长期间基本保持恒定长度,尽管力量和腹部长度发生了变化。这些模式在被动循环中不存在,表明腱膜的行为依赖于上下文。浅表腱膜在动物的应变模式中表现出相当大的变异性,特别是在主动缩短期间,与先前的体内测量一致。我们的研究结果挑战了腱膜和肌腱作为单一系列弹性元件的假设。相反,由于其复杂的结构和来自底层肌肉组织的负荷,腱膜表现出独特的机械行为。这些结果强调需要将腱膜和肌腱作为独立的结构来代表肌肉模型,以反映它们在收缩过程中的独特力学行为和作用。
{"title":"Differential mechanical behaviour of superficial and deep aponeurosis and tendon during in situ cyclic contractions of rabbit medial gastrocnemius muscle","authors":"Stephanie A. Ross,&nbsp;Christine Waters-Banker,&nbsp;Andrew Sawatsky,&nbsp;Timothy R. Leonard,&nbsp;Walter Herzog","doi":"10.1016/j.jbiomech.2026.113212","DOIUrl":"10.1016/j.jbiomech.2026.113212","url":null,"abstract":"<div><div>Aponeuroses are sheet-like extensions of tendon that transmit forces from muscle fascicles but experience more complex and heterogeneous loading than tendons. Despite this, most muscle models treat tendon and aponeurosis as a single, uniform elastic element in series with muscle. In this study, we examined strains of the superficial and deep aponeurosis and distal tendon of the rabbit medial gastrocnemius <em>in situ</em> under dynamic, physiologically relevant cyclic contractions. We found that, unlike tendon, aponeurosis did not exhibit strain patterns proportional to muscle force. Instead, both aponeuroses showed peak strain early in the activation phase and remained largely constant length during subsequent muscle shortening or lengthening, despite changes in force and belly length. These patterns were absent during passive cycles, indicating context-dependent behaviour of the aponeuroses. The superficial aponeurosis showed considerable variability in strain patterns across animals, particularly during active shortening, consistent with previous <em>in vivo</em> measures. Our findings challenge the assumption that aponeurosis and tendon function as a single series elastic element. Instead, aponeurosis exhibits distinct mechanical behaviour due to its complex structure and loading from the underlying muscle tissue. These results emphasize the need for muscle models that represent aponeurosis and tendon as separate structures, reflecting their unique mechanical behaviours and roles during contraction.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"199 ","pages":"Article 113212"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of biomechanics
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