Pub Date : 2026-03-21DOI: 10.1016/j.cardfail.2026.01.021
Juan B Ivey-Miranda, Samarth Rao, Zachary L Cox, Miguel Sandoval-Jimenez, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Genaro H Mendoza-Zavala, Cristina Revilla-Monsalve, Eduardo Almeida-Gutierrez, Edith L Posada-Martinez, Jeffrey M Testani
{"title":"Urine Sodium Variability during Continuous Loop Diuretic Infusion.","authors":"Juan B Ivey-Miranda, Samarth Rao, Zachary L Cox, Miguel Sandoval-Jimenez, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Genaro H Mendoza-Zavala, Cristina Revilla-Monsalve, Eduardo Almeida-Gutierrez, Edith L Posada-Martinez, Jeffrey M Testani","doi":"10.1016/j.cardfail.2026.01.021","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.01.021","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1016/j.cardfail.2026.03.012
S E Schroeder, S Chuzi, A Davies, K L Grady
{"title":"Integrating Palliative Care into LVAD Management: Evidence, Gaps, and Opportunities.","authors":"S E Schroeder, S Chuzi, A Davies, K L Grady","doi":"10.1016/j.cardfail.2026.03.012","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.012","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.cardfail.2026.02.039
Stephen J Greene, Javed Butler
{"title":"The Role of Vericiguat for Treatment of Heart Failure with Reduced Ejection Fraction.","authors":"Stephen J Greene, Javed Butler","doi":"10.1016/j.cardfail.2026.02.039","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.039","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1016/j.cardfail.2026.03.004
Grant Young, Juan Carlos Batlle, Katherine Aa Clark
{"title":"No Heart Failure Patient Left Behind: Making GDMT a Reality for All.","authors":"Grant Young, Juan Carlos Batlle, Katherine Aa Clark","doi":"10.1016/j.cardfail.2026.03.004","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.004","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.cardfail.2026.03.003
Filip Loncaric, Nina Jakus, Maja Cikes
{"title":"Dual antithrombotic therapy in the contemporary LVAD population - less is more.","authors":"Filip Loncaric, Nina Jakus, Maja Cikes","doi":"10.1016/j.cardfail.2026.03.003","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.cardfail.2026.03.006
Joseph D Abraham, William T Abraham
{"title":"Sleep Apnea in Heart Failure Patients with Preserved Ejection Fraction: Overlapping Syndromes, Negative Consequences: Sleep Apnea in HFpEF.","authors":"Joseph D Abraham, William T Abraham","doi":"10.1016/j.cardfail.2026.03.006","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.006","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.cardfail.2026.02.041
Alberto Aimo, Marianna Fontana
{"title":"The burden of amyloid transthyretin cardiomyopathy in heart failure with preserved ejection fraction: looking beyond the tip of the iceberg.","authors":"Alberto Aimo, Marianna Fontana","doi":"10.1016/j.cardfail.2026.02.041","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.041","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.cardfail.2026.01.023
Jason L Guichard, Eric L Bonno, Michael E Nassif, Taiyeb M Khumri, David Miranda, Orvar Jonsson, Hirak Shah, Tamas Alexy, Gregory P Macaluso, Gavin Hickey, Patrick McCann, Jennifer A Cowger, Amit Badiye, Yasmin Raza, Luke Masha, Chandra Kunavarapu, Mosi Bennett, Faisal Sharif, Michael Kiernan, Wilfried Mullens, Sandra V Chaparro, Claudius Mahr, Rohit R Amin, Lynne Warner Stevenson, Liviu Klein
Background: In the PROACTIVE-HF trial, remote heart failure (HF) management using comprehensive vital signs and seated mean pulmonary artery pressure (mPAP) was safe and resulted in a low reported rate of HF hospitalization (HFH) and all-cause mortality (HFH/D) through 12 months. In this report, we extend the results from the PROACTIVE-HF study through 2 years, stratified by ejection fraction (EF).
Methods and results: PROACTIVE-HF was a prospective, multi-center, open-label, single-arm trial evaluating the safety and efficacy of patient management using the CordellaTM PA pressure sensor system in patients with New York Heart Association (NYHA) class III symptoms, regardless of EF. In the first 24 months, the incidence of HF events (HFE)/D was 0.89 [95% CI: 0.81, 0.99] events per patient, driven by HFH. Patients with HF with reduced EF (HFrEF) had higher HFE/D rates than those with HF with preserved EF (HFpEF) (1.0 vs 0.8 events per patient, p=0.048).
Conclusions: For HF patients experiencing moderate-severe symptoms, management using the Cordella PA sensor system was associated with low event rates and improved health status at 2 years, regardless of EF. Comprehensive remote monitoring of vital signs, seated PAP, and patient-reported symptoms via a digital platform supports sustained benefit for high-risk patients with HF.
背景：在PROACTIVE-HF试验中，使用综合生命体征和坐位平均肺动脉压（mPAP）进行心力衰竭（HF）远程治疗是安全的，并且在12个月内导致较低的HF住院率（HFH）和全因死亡率（HFH/D）。在本报告中，我们将PROACTIVE-HF研究的结果延长了2年，并按射血分数（EF）分层。方法和结果：PROACTIVE-HF是一项前瞻性、多中心、开放标签、单臂试验，评估在患有纽约心脏协会（NYHA） III级症状的患者中使用CordellaTM PA压力传感器系统进行患者管理的安全性和有效性，无论是否有EF。在前24个月，HF事件(HFE)/D的发生率为每名患者0.89 [95% CI: 0.81, 0.99]事件，由HFH驱动。EF降低的HF患者（HFrEF）的HFE/D率高于EF保留的HF患者（HFpEF）（每例1.0 vs 0.8事件，p=0.048）。结论：对于出现中重度症状的心衰患者，使用Cordella PA传感器系统管理与低事件发生率和2年健康状况改善相关，无论EF如何。通过数字平台对生命体征、坐式PAP和患者报告的症状进行全面的远程监测，支持高危心衰患者的持续获益。
{"title":"Two Year Results of PROACTIVE-HF Trial Stratified by LVEF.","authors":"Jason L Guichard, Eric L Bonno, Michael E Nassif, Taiyeb M Khumri, David Miranda, Orvar Jonsson, Hirak Shah, Tamas Alexy, Gregory P Macaluso, Gavin Hickey, Patrick McCann, Jennifer A Cowger, Amit Badiye, Yasmin Raza, Luke Masha, Chandra Kunavarapu, Mosi Bennett, Faisal Sharif, Michael Kiernan, Wilfried Mullens, Sandra V Chaparro, Claudius Mahr, Rohit R Amin, Lynne Warner Stevenson, Liviu Klein","doi":"10.1016/j.cardfail.2026.01.023","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.01.023","url":null,"abstract":"<p><strong>Background: </strong>In the PROACTIVE-HF trial, remote heart failure (HF) management using comprehensive vital signs and seated mean pulmonary artery pressure (mPAP) was safe and resulted in a low reported rate of HF hospitalization (HFH) and all-cause mortality (HFH/D) through 12 months. In this report, we extend the results from the PROACTIVE-HF study through 2 years, stratified by ejection fraction (EF).</p><p><strong>Methods and results: </strong>PROACTIVE-HF was a prospective, multi-center, open-label, single-arm trial evaluating the safety and efficacy of patient management using the CordellaTM PA pressure sensor system in patients with New York Heart Association (NYHA) class III symptoms, regardless of EF. In the first 24 months, the incidence of HF events (HFE)/D was 0.89 [95% CI: 0.81, 0.99] events per patient, driven by HFH. Patients with HF with reduced EF (HFrEF) had higher HFE/D rates than those with HF with preserved EF (HFpEF) (1.0 vs 0.8 events per patient, p=0.048).</p><p><strong>Conclusions: </strong>For HF patients experiencing moderate-severe symptoms, management using the Cordella PA sensor system was associated with low event rates and improved health status at 2 years, regardless of EF. Comprehensive remote monitoring of vital signs, seated PAP, and patient-reported symptoms via a digital platform supports sustained benefit for high-risk patients with HF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.cardfail.2026.01.022
Jennifer A Cowger, Igor D Gregoric, Liviu Klein, Duc Thinh Pham, Michael S Kiernan, Kory J Lavine, Jonathan D Rich, Manjula G Ananthram, Ashwin Ravichandran, Alexis E Shafii, William Hiesinger, Brent C Lampert, Mandar A Aras, Claudius Mahr, Jeffrey J Teuteberg, Nader Moazami
{"title":"Lessons Learned from the HVAD Post Approval Study Registry: Implications for Investigating Future VAD Technology.","authors":"Jennifer A Cowger, Igor D Gregoric, Liviu Klein, Duc Thinh Pham, Michael S Kiernan, Kory J Lavine, Jonathan D Rich, Manjula G Ananthram, Ashwin Ravichandran, Alexis E Shafii, William Hiesinger, Brent C Lampert, Mandar A Aras, Claudius Mahr, Jeffrey J Teuteberg, Nader Moazami","doi":"10.1016/j.cardfail.2026.01.022","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.01.022","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Frailty is a multidimensional syndrome associated with adverse outcomes in heart failure. However, its prognostic significance in patients with advanced heart failure receiving a durable left ventricular assistive device (LVAD) remains unclear. This study aimed to investigate the association of frailty status with mortality and adverse events using a nationwide cohort of patients undergoing durable LVAD implantation.
Methods: We analysed data from the Japanese Registry for Mechanically Assisted Circulatory Support, including patients who underwent durable LVAD implantation between June 2010 and December 2023. Frailty status was assessed at 3 months after LVAD implantation using the frailty index (FI), which is based on the Rockwood cumulative deficits approach.
Results: In total, 508 (34.8%) were classified as not frail (FI ≤ 0.210), 669 (45.9%) as more frail (FI 0.211-0.310), and 281 (19.3%) as most frail (FI ≥ 0.311). During a median follow-up of 1,237 days, 230 patients (15.8%) died. Compared to patients in non-frail group, those in the more frail or most frail groups had a higher risk of all-cause death (more frail: adjusted sub-distribution hazard ratio [sHR] 2.04 [95% CI, 1.39-3.01]; most frail: 4.98 [3.34-7.43]). In addition, greater frailty was linked to increased risk of hemocompatibility-related adverse events and right ventricular failure but not driveline or pump infection, ventricular arrhythmia, or pump malfunction.
Conclusions: Frailty after LVAD implantation is highly prevalent and is associated with long-term mortality and other clinically relevant outcomes. A comprehensive frailty assessment may help stratify long-term risk after durable LVAD implantation.
{"title":"Impact of frailty on mortality and adverse events after durable left ventricular assist device implantation: Insights from the J-MACS registry.","authors":"Shingo Kazama, Toru Kondo, Takahiro Imaizumi, Shin Nagai, Asuka Nozaki, Shotaro Komeyama, Chiaki Mizuno, Ryota Ito, Hiroaki Hiraiwa, Ryota Morimoto, Yasunari Hayashi, Tomo Yoshizumi, Jawad H Butt, Yoshikatsu Saiki, Hiroshi Niinami, Minoru Ono, Toyoaki Murohara, Masato Mutsuga","doi":"10.1016/j.cardfail.2026.02.051","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.051","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a multidimensional syndrome associated with adverse outcomes in heart failure. However, its prognostic significance in patients with advanced heart failure receiving a durable left ventricular assistive device (LVAD) remains unclear. This study aimed to investigate the association of frailty status with mortality and adverse events using a nationwide cohort of patients undergoing durable LVAD implantation.</p><p><strong>Methods: </strong>We analysed data from the Japanese Registry for Mechanically Assisted Circulatory Support, including patients who underwent durable LVAD implantation between June 2010 and December 2023. Frailty status was assessed at 3 months after LVAD implantation using the frailty index (FI), which is based on the Rockwood cumulative deficits approach.</p><p><strong>Results: </strong>In total, 508 (34.8%) were classified as not frail (FI ≤ 0.210), 669 (45.9%) as more frail (FI 0.211-0.310), and 281 (19.3%) as most frail (FI ≥ 0.311). During a median follow-up of 1,237 days, 230 patients (15.8%) died. Compared to patients in non-frail group, those in the more frail or most frail groups had a higher risk of all-cause death (more frail: adjusted sub-distribution hazard ratio [sHR] 2.04 [95% CI, 1.39-3.01]; most frail: 4.98 [3.34-7.43]). In addition, greater frailty was linked to increased risk of hemocompatibility-related adverse events and right ventricular failure but not driveline or pump infection, ventricular arrhythmia, or pump malfunction.</p><p><strong>Conclusions: </strong>Frailty after LVAD implantation is highly prevalent and is associated with long-term mortality and other clinically relevant outcomes. A comprehensive frailty assessment may help stratify long-term risk after durable LVAD implantation.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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