Pub Date : 2026-03-12DOI: 10.1016/j.cardfail.2026.03.005
Catherine G Derington, Karen Joynt Maddox, Larry A Allen
{"title":"A Tale of Two Medicares: The Medicare Advantage Experience for Patients with Heart Failure.","authors":"Catherine G Derington, Karen Joynt Maddox, Larry A Allen","doi":"10.1016/j.cardfail.2026.03.005","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.005","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1016/j.cardfail.2026.01.025
Julie Hempel Larsen, Camilla Fuchs Andersen, Maria Callesen Hansen, Massar Omar, Jesper Jensen, Lisbeth Antonsen, Per Lav Madsen, Julie Lyng Forman, Kurt Højlund, Filip Krag Knop, Mikael Kjær Poulsen, Morten Schou, Jacob Eifer Møller
Background and aim: Increased left ventricular (LV) mass is a predictor of HF. The preventive effect of sodium-glucose cotransporter 2 inhibitors remain unclear in subjects without heart failure (HF). The aim was to evaluate the effect of empagliflozin on LV mass index (LVMI) and LV volumes in individuals with overweight and considered at risk of HF.
Method and results: Investigator-initiated, double-blinded, randomized, placebo-controlled, multicenter superiority trial [NCT05084235] in 191 elderly (60-84 years), overweight (body mass index (BMI) >28 kg/m2) individuals with at least one known risk factor for HF (hypertension, ischemic heart disease, stroke, chronic kidney disease were randomized 1:1 to empagliflozin 10 mg or matching placebo for 180 days. Individuals with HF or T2D were excluded. The primary endpoint was change in LVMI from baseline to 180 days assessed by cardiac MRI, with between-group comparisons expressed as adjusted mean differences. Secondary endpoints were mean differences in changes of LV end-diastolic volume index (LVEDVI), LV end-systolic volume index (LVESVI), and LV ejection fraction (LVEF). Of 191 randomized, 165 individuals (median age 68 years, median BMI 31.8 kg/m2, 67% were male, and median LVEF 65%) completed MRI (empagliflozin: 83; placebo: 82). Empagliflozin reduced LVMI with an estimated treatment difference of -1.9 g/m2 (97.5% CI: (-3.5 to -0.2), p=0.01). No significant differences were observed for LV volumes or ejection fraction.
Conclusion: Among elderly individuals with overweight and cardiovascular disease Empagliflozin 10 mg daily compared to placebo for 180 days led to a significant reduction in LVMI.
{"title":"The effect of empagliflozin on left ventricular mass and volumes in elderly individuals with overweight and high risk of heart failure: The Empire Prevent Cardiac Trial.","authors":"Julie Hempel Larsen, Camilla Fuchs Andersen, Maria Callesen Hansen, Massar Omar, Jesper Jensen, Lisbeth Antonsen, Per Lav Madsen, Julie Lyng Forman, Kurt Højlund, Filip Krag Knop, Mikael Kjær Poulsen, Morten Schou, Jacob Eifer Møller","doi":"10.1016/j.cardfail.2026.01.025","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.01.025","url":null,"abstract":"<p><strong>Background and aim: </strong>Increased left ventricular (LV) mass is a predictor of HF. The preventive effect of sodium-glucose cotransporter 2 inhibitors remain unclear in subjects without heart failure (HF). The aim was to evaluate the effect of empagliflozin on LV mass index (LVMI) and LV volumes in individuals with overweight and considered at risk of HF.</p><p><strong>Method and results: </strong>Investigator-initiated, double-blinded, randomized, placebo-controlled, multicenter superiority trial [NCT05084235] in 191 elderly (60-84 years), overweight (body mass index (BMI) >28 kg/m<sup>2</sup>) individuals with at least one known risk factor for HF (hypertension, ischemic heart disease, stroke, chronic kidney disease were randomized 1:1 to empagliflozin 10 mg or matching placebo for 180 days. Individuals with HF or T2D were excluded. The primary endpoint was change in LVMI from baseline to 180 days assessed by cardiac MRI, with between-group comparisons expressed as adjusted mean differences. Secondary endpoints were mean differences in changes of LV end-diastolic volume index (LVEDVI), LV end-systolic volume index (LVESVI), and LV ejection fraction (LVEF). Of 191 randomized, 165 individuals (median age 68 years, median BMI 31.8 kg/m<sup>2</sup>, 67% were male, and median LVEF 65%) completed MRI (empagliflozin: 83; placebo: 82). Empagliflozin reduced LVMI with an estimated treatment difference of -1.9 g/m<sup>2</sup> (97.5% CI: (-3.5 to -0.2), p=0.01). No significant differences were observed for LV volumes or ejection fraction.</p><p><strong>Conclusion: </strong>Among elderly individuals with overweight and cardiovascular disease Empagliflozin 10 mg daily compared to placebo for 180 days led to a significant reduction in LVMI.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1016/j.cardfail.2026.02.040
Iacopo Fabiani, Francesco Gentile, Giorgia Panichella, Michele Emdin
{"title":"PAWP vs. LVEDP During Invasive Cardiopulmonary Exercise Testing: in search of the Holy Grail of a Hemodynamic Truth in Heart Failure.","authors":"Iacopo Fabiani, Francesco Gentile, Giorgia Panichella, Michele Emdin","doi":"10.1016/j.cardfail.2026.02.040","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.040","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1016/j.cardfail.2026.02.028
Scott Lundgren
{"title":"Normalizing Congestion: The Role of Inferior Vena Cava Sensors in Heart Failure.","authors":"Scott Lundgren","doi":"10.1016/j.cardfail.2026.02.028","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.028","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.cardfail.2026.03.009
Ishan Garg, Aman Goyal, Karthik Gangu, Malik Alqawasmi, Alexandra C Millhuff, Rudra Pratap Singh, Nicole Silva Collantes, Mohammed Quazi, Abu Baker Sheikh
{"title":"Acute Heart Failure in U.S. Emergency Departments: Burden, Predictors of Admission, and Regional Variation.","authors":"Ishan Garg, Aman Goyal, Karthik Gangu, Malik Alqawasmi, Alexandra C Millhuff, Rudra Pratap Singh, Nicole Silva Collantes, Mohammed Quazi, Abu Baker Sheikh","doi":"10.1016/j.cardfail.2026.03.009","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.03.009","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.cardfail.2026.02.048
Jonas Erzeel, Marnicq van Es, Petra Nijst, Michiel De Wever, Evelyne Meekers, Sebastiaan Dhont, Gabor Voros, Rik Willems, Matthias Dupont, Pieter Martens, Wilfried Mullens
{"title":"Withdrawal of neurohumoral blockade in patients with normalized ejection fraction after cardiac resynchronization therapy: long-term follow-up of the STOP-CRT trial.","authors":"Jonas Erzeel, Marnicq van Es, Petra Nijst, Michiel De Wever, Evelyne Meekers, Sebastiaan Dhont, Gabor Voros, Rik Willems, Matthias Dupont, Pieter Martens, Wilfried Mullens","doi":"10.1016/j.cardfail.2026.02.048","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.048","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.cardfail.2026.02.027
Ersilia M DeFilippis, Koji Takeda, Gabriel Sayer
{"title":"Ex Vivo Heart Perfusion: A Transformative Technology Still Out of Reach.","authors":"Ersilia M DeFilippis, Koji Takeda, Gabriel Sayer","doi":"10.1016/j.cardfail.2026.02.027","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.027","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.cardfail.2026.02.034
Alexandra I Mansour, Jessica Barkdoll, Sarah Riley, Kamishia Thomas, Ama Awuah-Asamoah, Maxwell Ditlevson, LeeAnn Henry, Shawna Deshields, Julianne Chambers, Martha Abshire-Saylor, Jill Patton, Nisha A Gilotra
{"title":"Words Matter: Implementation and outcomes of a humanizing medicine initiative in a heart failure disease management clinic.","authors":"Alexandra I Mansour, Jessica Barkdoll, Sarah Riley, Kamishia Thomas, Ama Awuah-Asamoah, Maxwell Ditlevson, LeeAnn Henry, Shawna Deshields, Julianne Chambers, Martha Abshire-Saylor, Jill Patton, Nisha A Gilotra","doi":"10.1016/j.cardfail.2026.02.034","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.02.034","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.cardfail.2026.02.037
Lynne Warner Stevenson, Ryan J Tedford
{"title":"Remote Monitoring to Optimize Guideline-Directed Medical Therapy Beyond Diuretics.","authors":"Lynne Warner Stevenson, Ryan J Tedford","doi":"10.1016/j.cardfail.2026.02.037","DOIUrl":"10.1016/j.cardfail.2026.02.037","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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