首页 > 最新文献

Journal of Cardiac Failure最新文献

英文 中文
Influence of Environmental Temperature on the Occurrence of Driveline Infection in LVAD Patients.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-26 DOI: 10.1016/j.cardfail.2025.01.024
Filippo Calì, Alberto Pinsino, Annamaria Ladanyi, Giulio M Mondellini, Changhee Lee, Gabriel T Sayer, Yuji Kaku, Nir Uriel, Koji Takeda, Justin G Aaron, Melana Yuzefpolskaya, Paolo C Colombo
{"title":"Influence of Environmental Temperature on the Occurrence of Driveline Infection in LVAD Patients.","authors":"Filippo Calì, Alberto Pinsino, Annamaria Ladanyi, Giulio M Mondellini, Changhee Lee, Gabriel T Sayer, Yuji Kaku, Nir Uriel, Koji Takeda, Justin G Aaron, Melana Yuzefpolskaya, Paolo C Colombo","doi":"10.1016/j.cardfail.2025.01.024","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.024","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of initiation with sacubitril/valsartan on blood neurodegeneration markers in HFrEF.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-26 DOI: 10.1016/j.cardfail.2025.01.021
Suriya Prausmüller, Raphael Wurm, Markus Ponleitner, Elisabeth Stögmann, Martin Hulsmann, Noemi Pavo

Background: Sacubitril/valsartan is a key therapy for heart failure with reduced ejection fraction (HFrEF). However, concerns remain regarding its potential impact on cognitive function since neprilysin inhibition may influence amyloid-β (Aβ) metabolism. This study evaluates the effect of sacubitril/valsartan on plasma biomarkers of neurodegeneration.

Methods: Plasma neuromarkers, i.e. Aβ40, Aβ42, neurofilament light chain (NfL), and total tau (t-tau) were measured at baseline, 3 months, and 1 year after sacubitril/valsartan initiation using the single-molecule array (SIMOA) technology in a HFrEF cohort from a prospective registry with biobank. Comparisons were made for baseline vs. 3 months and baseline vs 1-year follow-up.

Results: A total of 31 HFrEF patients (median age: 61 years, 74% male, NT-proBNP: 2333 pg/ml) were included. Aβ40 increased transiently at 3 months [228.6 pg/ml (Q1-Q3: 157.8-321.1) vs. 138.8 (110.0-202.2), p < 0.001] but remained unchanged at 1 year [215.0 (106.5-290.9), p = 0.052]. Aβ42 remained stable [9.90 (6.67-12.49) and 8.43 (5.57-11.86) vs. 7.84 (6.50-11.02) pg/ml, p = 0.108 and 0.771], resulting in a reduced Aβ42/Aβ40 ratio at both follow-ups [0.039 (0.036-0.049) at 3 months, p < 0.001; 0.048 (0.041-0.060) at 1 year, p = 0.026 vs. 0.055 (0.052-0.061)]. Total tau remained unchanged [1.13 (0.91-1.90) and 1.21 (0.85-1.65) vs. 1.03 (0.82-1.53) pg/ml, p = 0.068 and 0.188], while NfL increased at 1 year [28.3 (16.5-78.6) vs. 22.6 (15.1-46.9) pg/ml, p = 0.013], with no short-term change [25.3 (15.0-51.3), p = 0.502].

Conclusion: Sacubitril/valsartan therapy in HFrEF patients leads to a transient increase in Aβ40 and a sustained reduction in the Aβ42/Aβ40 ratio. Stable t-tau and short-term stable NfL levels provide reassurance regarding the absence of immediate neuronal injury, while an NfL increase observed at 1 year may indicate ongoing heart failure progression rather than direct neurotoxicity. These findings highlight the need for cautious interpretation of the Aβ42/Aβ40 ratio in neurocognitive assessments among patients treated with ARNi. Further studies are warranted to clarify the long-term cognitive implications of sacubitril/valsartan in HFrEF.

{"title":"Effect of initiation with sacubitril/valsartan on blood neurodegeneration markers in HFrEF.","authors":"Suriya Prausmüller, Raphael Wurm, Markus Ponleitner, Elisabeth Stögmann, Martin Hulsmann, Noemi Pavo","doi":"10.1016/j.cardfail.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>Sacubitril/valsartan is a key therapy for heart failure with reduced ejection fraction (HFrEF). However, concerns remain regarding its potential impact on cognitive function since neprilysin inhibition may influence amyloid-β (Aβ) metabolism. This study evaluates the effect of sacubitril/valsartan on plasma biomarkers of neurodegeneration.</p><p><strong>Methods: </strong>Plasma neuromarkers, i.e. Aβ40, Aβ42, neurofilament light chain (NfL), and total tau (t-tau) were measured at baseline, 3 months, and 1 year after sacubitril/valsartan initiation using the single-molecule array (SIMOA) technology in a HFrEF cohort from a prospective registry with biobank. Comparisons were made for baseline vs. 3 months and baseline vs 1-year follow-up.</p><p><strong>Results: </strong>A total of 31 HFrEF patients (median age: 61 years, 74% male, NT-proBNP: 2333 pg/ml) were included. Aβ40 increased transiently at 3 months [228.6 pg/ml (Q1-Q3: 157.8-321.1) vs. 138.8 (110.0-202.2), p < 0.001] but remained unchanged at 1 year [215.0 (106.5-290.9), p = 0.052]. Aβ42 remained stable [9.90 (6.67-12.49) and 8.43 (5.57-11.86) vs. 7.84 (6.50-11.02) pg/ml, p = 0.108 and 0.771], resulting in a reduced Aβ42/Aβ40 ratio at both follow-ups [0.039 (0.036-0.049) at 3 months, p < 0.001; 0.048 (0.041-0.060) at 1 year, p = 0.026 vs. 0.055 (0.052-0.061)]. Total tau remained unchanged [1.13 (0.91-1.90) and 1.21 (0.85-1.65) vs. 1.03 (0.82-1.53) pg/ml, p = 0.068 and 0.188], while NfL increased at 1 year [28.3 (16.5-78.6) vs. 22.6 (15.1-46.9) pg/ml, p = 0.013], with no short-term change [25.3 (15.0-51.3), p = 0.502].</p><p><strong>Conclusion: </strong>Sacubitril/valsartan therapy in HFrEF patients leads to a transient increase in Aβ40 and a sustained reduction in the Aβ42/Aβ40 ratio. Stable t-tau and short-term stable NfL levels provide reassurance regarding the absence of immediate neuronal injury, while an NfL increase observed at 1 year may indicate ongoing heart failure progression rather than direct neurotoxicity. These findings highlight the need for cautious interpretation of the Aβ42/Aβ40 ratio in neurocognitive assessments among patients treated with ARNi. Further studies are warranted to clarify the long-term cognitive implications of sacubitril/valsartan in HFrEF.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences Between Ischemic and Nonischemic Cardiomyopathy in Heart Failure Related Cardiogenic Shock.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-26 DOI: 10.1016/j.cardfail.2025.01.020
Jason Feinman, Matthew I Tomey, Michael G Palazzolo, Miguel Martillo, Maria Ronquillo, Noah Moss, Gregory Serrao, Erin A Bohula, David D Berg, Sean VAN Diepen, Jason N Katz, Meshe D Chonde, Sunit-Preet Chaudhry, Alvin J George, Daniel Gerber, Michael J Goldfarb, Norma M Keller, Michael C Kontos, Daniel B Loriaux, Connor G O'Brien, Barbara A Pisani, Alastair Proudfoot, Kiran Sidhu, Shashank S Sinha, Lakshmi Sridharan, Natalie Tapaskar, Alexander Thomas, Andrea D Thompson, David A Morrow, Umesh Gidwani, Evan Leibner

Background: Heart failure-related cardiogenic shock (HF-CS) accounts for a growing proportion of cardiogenic shock (CS)-related admissions to contemporary cardiac intensive care units. Limited data exist comparing nonischemic (NICM) and ischemic cardiomyopathy (ICM) in this setting.

Methods and results: We sought to examine the differences in patients' characteristics, in-hospital treatments and outcomes in individuals admitted with ICM and NICM HF-CS. The study population included CS admissions within the Critical Care Cardiology Trials Network registry from 2017-2022. CS due to acute myocardial infarction or secondary causes was excluded. Admission characteristics, in-hospital treatments and outcomes were captured. The primary outcome of all-cause in-hospital mortality for ICM vs NICM was compared by using multivariable logistic regression; 2463 hospital admissions for HF-CS, including 902 (36.6%) admissions with ICM and 1561 (63.4%) admissions with NICM, were included. Patients with ICM more commonly had pre-existing comorbidities, pre-admission cardiac arrest and higher Sequential Organ Failure Assessment scores. The use of inotropes and temporary mechanical circulatory support was similar; however, the rates of mechanical ventilation and renal-replacement therapies were higher for ICM. Patients with ICM were less likely to undergo cardiac transplantation but had similar rates of durable left ventricular assist device implantation. After multivariable adjustment, patients with ICM were significantly more likely to die during the index hospitalization (OR 1.56, 95% CI 1.26-1.93; P < 0.001).

Conclusions: Among patients admitted to cardiac intensive care units with HF-CS, patients with ICM were sicker, less likely to undergo cardiac transplantation, and more likely to die when compared with patients with NICM.

背景:在当代心脏重症监护病房收治的心源性休克(CS)患者中,心衰相关心源性休克(HF-CS)所占比例越来越大。在这种情况下,比较非缺血性(NICM)和缺血性心肌病(ICM)的数据有限:我们试图研究 ICM 和 NICM HF-CS 患者在患者特征、院内治疗和预后方面的差异。研究对象包括重症心脏病学试验网络登记处 2017 年至 2022 年收治的 CS 患者。因急性心肌梗死或继发性原因导致的CS不包括在内。记录了入院特征、院内治疗和结果。采用多变量逻辑回归法比较了 ICM 与 NICM 的主要结局(全因院内死亡率)。共纳入 2463 例 HF-CS 住院病例,包括 902 例(36.6%)ICM 住院病例和 1561 例(63.4%)NICM 住院病例。ICM 患者更常见的并发症是入院前心脏骤停,以及更高的器官功能衰竭序列评估评分。肌注和临时机械循环支持的使用情况相似;但 ICM 患者使用机械通气和肾脏替代疗法的比例更高。ICM 患者接受心脏移植的可能性较低,但植入耐用左心室辅助装置的比例相似。经过多变量调整后,ICM 患者在指数住院期间死亡的可能性明显更高(OR 1.56,95% CI 1.26-1.93;P 结论:ICM 患者在指数住院期间死亡的可能性明显更高(OR 1.56,95% CI 1.26-1.93):在入住 CICU 的 HF-CS 患者中,与 NICM 患者相比,ICM 患者病情更重,接受心脏移植的可能性更小,死亡的可能性更大。
{"title":"Differences Between Ischemic and Nonischemic Cardiomyopathy in Heart Failure Related Cardiogenic Shock.","authors":"Jason Feinman, Matthew I Tomey, Michael G Palazzolo, Miguel Martillo, Maria Ronquillo, Noah Moss, Gregory Serrao, Erin A Bohula, David D Berg, Sean VAN Diepen, Jason N Katz, Meshe D Chonde, Sunit-Preet Chaudhry, Alvin J George, Daniel Gerber, Michael J Goldfarb, Norma M Keller, Michael C Kontos, Daniel B Loriaux, Connor G O'Brien, Barbara A Pisani, Alastair Proudfoot, Kiran Sidhu, Shashank S Sinha, Lakshmi Sridharan, Natalie Tapaskar, Alexander Thomas, Andrea D Thompson, David A Morrow, Umesh Gidwani, Evan Leibner","doi":"10.1016/j.cardfail.2025.01.020","DOIUrl":"10.1016/j.cardfail.2025.01.020","url":null,"abstract":"<p><strong>Background: </strong>Heart failure-related cardiogenic shock (HF-CS) accounts for a growing proportion of cardiogenic shock (CS)-related admissions to contemporary cardiac intensive care units. Limited data exist comparing nonischemic (NICM) and ischemic cardiomyopathy (ICM) in this setting.</p><p><strong>Methods and results: </strong>We sought to examine the differences in patients' characteristics, in-hospital treatments and outcomes in individuals admitted with ICM and NICM HF-CS. The study population included CS admissions within the Critical Care Cardiology Trials Network registry from 2017-2022. CS due to acute myocardial infarction or secondary causes was excluded. Admission characteristics, in-hospital treatments and outcomes were captured. The primary outcome of all-cause in-hospital mortality for ICM vs NICM was compared by using multivariable logistic regression; 2463 hospital admissions for HF-CS, including 902 (36.6%) admissions with ICM and 1561 (63.4%) admissions with NICM, were included. Patients with ICM more commonly had pre-existing comorbidities, pre-admission cardiac arrest and higher Sequential Organ Failure Assessment scores. The use of inotropes and temporary mechanical circulatory support was similar; however, the rates of mechanical ventilation and renal-replacement therapies were higher for ICM. Patients with ICM were less likely to undergo cardiac transplantation but had similar rates of durable left ventricular assist device implantation. After multivariable adjustment, patients with ICM were significantly more likely to die during the index hospitalization (OR 1.56, 95% CI 1.26-1.93; P < 0.001).</p><p><strong>Conclusions: </strong>Among patients admitted to cardiac intensive care units with HF-CS, patients with ICM were sicker, less likely to undergo cardiac transplantation, and more likely to die when compared with patients with NICM.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and Prognostic Significance of Acute Non-Cardiac Organ Dysfunction across Cardiogenic Shock Subtypes: Varshney et al; Non-Cardiac Organ Dysfunction in CS.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-25 DOI: 10.1016/j.cardfail.2024.12.017
Anubodh S Varshney, Michael G Palazzolo, Christopher F Barnett, Erin A Bohula, James A Burke, Sunit-Preet Chaudhry, Meshe D Chonde, Shahab Ghafghazi, Daniel A Gerber, Benjamin Kenigsberg, Michael C Kontos, Younghoon Kwon, Patrick R Lawler, Daniel B Loriaux, Venu Menon, Elliott Miller, Connor G O'Brien, Alexander I Papolos, Siddharth M Patel, Brian J Potter, Rajnish Prasad, Kevin S Shah, Shashank S Sinha, Michael A Solomon, Andrea Thompson, Jeffrey J Teuteberg, Sean van Diepen, David A Morrow, David D Berg

Background: The epidemiology and prognostic significance of acute non-cardiac organ dysfunction across cardiogenic shock (CS) subtypes are not well-defined.

Methods: CS admissions from 2017-2022 in the Critical Care Cardiology Trials Network Registry were classified as acute myocardial infarction-related CS (AMI-CS), acute-on-chronic heart failure-related CS (AoC HF-CS), or de novo HF-CS, and categorized as having at least moderate respiratory, kidney, liver, and/or neurologic dysfunction using established criteria. Burden of organ dysfunction was defined as no organ dysfunction (NOD), single organ dysfunction (SOD), or multi (≥2) organ dysfunction (MOD). Multivariable models were used to evaluate associations of burden and type of non-cardiac organ dysfunction with in-hospital death.

Results: Among 3,904 CS admissions, 29.4% had AMI-CS, 50.9% had AoC HF-CS, and 19.7% had de novo HF-CS. AMI-CS and de novo HF-CS had greater prevalence of MOD (35.0% and 33.9%, respectively) compared with AoC HF-CS (23.1%; p<0.01). In-hospital mortality was higher with greater burden of organ dysfunction in the overall CS cohort (SOD vs. NOD: adjusted odds ratio [aOR] for in-hospital death 2.5, 95% confidence interval [CI] 2.0-3.2; MOD vs. NOD: aOR 6.5, 95% CI 5.1-8.2) and across each CS subtype. Kidney dysfunction was the most prognostically important form of organ dysfunction in the overall cohort (aOR 4.1, 95% CI 3.4-5.0) and for each CS subtype.

Conclusion: Admissions for AoC HF-CS had a lower burden of acute non-cardiac organ dysfunction compared with admissions for de novo HF-CS and AMI-CS. However, acute non-cardiac organ dysfunction burden was similarly adversely prognostic across all CS subtypes.

背景:心源性休克(CS)亚型的急性非心脏器官功能障碍的流行病学和预后意义尚未明确:心源性休克(CS)亚型中急性非心脏器官功能障碍的流行病学和预后意义尚未明确:重症心脏病学试验网络登记处将2017-2022年收治的CS患者分为急性心肌梗死相关CS(AMI-CS)、急性慢性心力衰竭相关CS(AoC HF-CS)或新发HF-CS,并使用既定标准将其分为至少中度呼吸、肾、肝和/或神经功能障碍。器官功能障碍的负担被定义为无器官功能障碍(NOD)、单器官功能障碍(SOD)或多器官(≥2)功能障碍(MOD)。采用多变量模型评估非心脏器官功能障碍的负担和类型与院内死亡的关系:在 3904 例 CS 住院患者中,29.4% 患有 AMI-CS,50.9% 患有 AoC HF-CS,19.7% 患有新发 HF-CS。与AoC HF-CS相比,AMI-CS和新发HF-CS的MOD发病率更高(分别为35.0%和33.9%)(23.1%;P结论:与新发高频综合征和急性心肌梗死综合征相比,急性非心脏器官功能障碍的发生率较低。然而,急性非心脏器官功能障碍对所有 CS 亚型的预后都有不利影响。
{"title":"Epidemiology and Prognostic Significance of Acute Non-Cardiac Organ Dysfunction across Cardiogenic Shock Subtypes: Varshney et al; Non-Cardiac Organ Dysfunction in CS.","authors":"Anubodh S Varshney, Michael G Palazzolo, Christopher F Barnett, Erin A Bohula, James A Burke, Sunit-Preet Chaudhry, Meshe D Chonde, Shahab Ghafghazi, Daniel A Gerber, Benjamin Kenigsberg, Michael C Kontos, Younghoon Kwon, Patrick R Lawler, Daniel B Loriaux, Venu Menon, Elliott Miller, Connor G O'Brien, Alexander I Papolos, Siddharth M Patel, Brian J Potter, Rajnish Prasad, Kevin S Shah, Shashank S Sinha, Michael A Solomon, Andrea Thompson, Jeffrey J Teuteberg, Sean van Diepen, David A Morrow, David D Berg","doi":"10.1016/j.cardfail.2024.12.017","DOIUrl":"https://doi.org/10.1016/j.cardfail.2024.12.017","url":null,"abstract":"<p><strong>Background: </strong>The epidemiology and prognostic significance of acute non-cardiac organ dysfunction across cardiogenic shock (CS) subtypes are not well-defined.</p><p><strong>Methods: </strong>CS admissions from 2017-2022 in the Critical Care Cardiology Trials Network Registry were classified as acute myocardial infarction-related CS (AMI-CS), acute-on-chronic heart failure-related CS (AoC HF-CS), or de novo HF-CS, and categorized as having at least moderate respiratory, kidney, liver, and/or neurologic dysfunction using established criteria. Burden of organ dysfunction was defined as no organ dysfunction (NOD), single organ dysfunction (SOD), or multi (≥2) organ dysfunction (MOD). Multivariable models were used to evaluate associations of burden and type of non-cardiac organ dysfunction with in-hospital death.</p><p><strong>Results: </strong>Among 3,904 CS admissions, 29.4% had AMI-CS, 50.9% had AoC HF-CS, and 19.7% had de novo HF-CS. AMI-CS and de novo HF-CS had greater prevalence of MOD (35.0% and 33.9%, respectively) compared with AoC HF-CS (23.1%; p<0.01). In-hospital mortality was higher with greater burden of organ dysfunction in the overall CS cohort (SOD vs. NOD: adjusted odds ratio [aOR] for in-hospital death 2.5, 95% confidence interval [CI] 2.0-3.2; MOD vs. NOD: aOR 6.5, 95% CI 5.1-8.2) and across each CS subtype. Kidney dysfunction was the most prognostically important form of organ dysfunction in the overall cohort (aOR 4.1, 95% CI 3.4-5.0) and for each CS subtype.</p><p><strong>Conclusion: </strong>Admissions for AoC HF-CS had a lower burden of acute non-cardiac organ dysfunction compared with admissions for de novo HF-CS and AMI-CS. However, acute non-cardiac organ dysfunction burden was similarly adversely prognostic across all CS subtypes.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inertia Is Not an Option: Laying the Foundation for a Consensus on the Assessment of Kidney Function in Acute Decompensated Heart Failure.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-25 DOI: 10.1016/j.cardfail.2025.01.025
Isabella Cavagna, Mona Fiuzat, Anuradha Lala, James Januzzi, William Abraham, Matthew Dimond, Marvin Konstam, Christopher O'Connor, Maria Rosa Costanzo

none.

{"title":"Inertia Is Not an Option: Laying the Foundation for a Consensus on the Assessment of Kidney Function in Acute Decompensated Heart Failure.","authors":"Isabella Cavagna, Mona Fiuzat, Anuradha Lala, James Januzzi, William Abraham, Matthew Dimond, Marvin Konstam, Christopher O'Connor, Maria Rosa Costanzo","doi":"10.1016/j.cardfail.2025.01.025","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.025","url":null,"abstract":"<p><p>none.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weighing the Future: A Novel Tool to Manage Patients With Heart Failure.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-22 DOI: 10.1016/j.cardfail.2025.02.009
Anjan Tibrewala, Jane E Wilcox
{"title":"Weighing the Future: A Novel Tool to Manage Patients With Heart Failure.","authors":"Anjan Tibrewala, Jane E Wilcox","doi":"10.1016/j.cardfail.2025.02.009","DOIUrl":"10.1016/j.cardfail.2025.02.009","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicted Heart Mass and Outcomes in the Contemporary Era of Heart Transplantation: Insights from the Dallas Heart Study.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-22 DOI: 10.1016/j.cardfail.2025.01.023
Ersilia M DeFilippis, Lauren K Truby, Sonia Garg, Elaine Wu, Hadi Beaini, Matthias Peltz, Mark H Drazner, Natalie Bello, Maryjane A Farr

Background: Donor-recipient size matching is a key factor in donor selection in heart transplantation (HT). One approach uses predicted heart mass (PHM), derived from the Multi-ethnic Study of Atherosclerosis (MESA). We sought to examine whether predicted left ventricular mass (PLVM) derived from the Dallas Heart Study (DHS) is associated with post-transplant outcomes.

Methods: The study cohort included participants without pre-existing cardiac disease in DHS who had a cardiac MRI (n=1,746). A PLVM model was derived by linear regression. The DHS PLVM and MESA PHM were tested for correlation. The associations of DHS PLVM and MESA PHM with 1-year mortality post-HT were assessed in the United Network for Organ Sharing Registry in three eras (Era 1: 1/1/2011-12/31/2014, Era 2: 1/1/2015-10/17/2018, and Era 3 10/18/2018 - 12/31/2021). A pre-specified threshold for low donor-to-recipient mass ratio (< 0.86) was used in Kaplan Meier survival estimation and univariate and multivariable Cox proportional hazard models.

Results: The DHS cohort had a median age of 43 (IQR 36-52) years, 49% male, 40% Black, and 18% Hispanic ethnicity. DHS PLVM was highly correlated with MESA PHM: r = 0.96, p <0.001. In Era 1, a low donor-to-recipient mass ratio by DHS PLVM was associated with increased 1-year mortality (log-rank p<0.001) as was MESA PHM (log rank p = 0.002). However, in Eras 2 and 3, a low donor-to-recipient mass ratio by either DHS PLVM or MESA PHM was not associated with increased 1-year mortality.

Conclusion: PLVM was highly correlated with PHM. A low donor-to-recipient mass ratio, whether assessed by PLVM or PHM, was associated with 1-year mortality post-HT in a historical era but not in the current era under the new allocation system. These findings suggest that other factors may be contributing to donor selection and mortality risk in the modern era.

{"title":"Predicted Heart Mass and Outcomes in the Contemporary Era of Heart Transplantation: Insights from the Dallas Heart Study.","authors":"Ersilia M DeFilippis, Lauren K Truby, Sonia Garg, Elaine Wu, Hadi Beaini, Matthias Peltz, Mark H Drazner, Natalie Bello, Maryjane A Farr","doi":"10.1016/j.cardfail.2025.01.023","DOIUrl":"https://doi.org/10.1016/j.cardfail.2025.01.023","url":null,"abstract":"<p><strong>Background: </strong>Donor-recipient size matching is a key factor in donor selection in heart transplantation (HT). One approach uses predicted heart mass (PHM), derived from the Multi-ethnic Study of Atherosclerosis (MESA). We sought to examine whether predicted left ventricular mass (PLVM) derived from the Dallas Heart Study (DHS) is associated with post-transplant outcomes.</p><p><strong>Methods: </strong>The study cohort included participants without pre-existing cardiac disease in DHS who had a cardiac MRI (n=1,746). A PLVM model was derived by linear regression. The DHS PLVM and MESA PHM were tested for correlation. The associations of DHS PLVM and MESA PHM with 1-year mortality post-HT were assessed in the United Network for Organ Sharing Registry in three eras (Era 1: 1/1/2011-12/31/2014, Era 2: 1/1/2015-10/17/2018, and Era 3 10/18/2018 - 12/31/2021). A pre-specified threshold for low donor-to-recipient mass ratio (< 0.86) was used in Kaplan Meier survival estimation and univariate and multivariable Cox proportional hazard models.</p><p><strong>Results: </strong>The DHS cohort had a median age of 43 (IQR 36-52) years, 49% male, 40% Black, and 18% Hispanic ethnicity. DHS PLVM was highly correlated with MESA PHM: r = 0.96, p <0.001. In Era 1, a low donor-to-recipient mass ratio by DHS PLVM was associated with increased 1-year mortality (log-rank p<0.001) as was MESA PHM (log rank p = 0.002). However, in Eras 2 and 3, a low donor-to-recipient mass ratio by either DHS PLVM or MESA PHM was not associated with increased 1-year mortality.</p><p><strong>Conclusion: </strong>PLVM was highly correlated with PHM. A low donor-to-recipient mass ratio, whether assessed by PLVM or PHM, was associated with 1-year mortality post-HT in a historical era but not in the current era under the new allocation system. These findings suggest that other factors may be contributing to donor selection and mortality risk in the modern era.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of GLP-1 Receptor Agonists in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-22 DOI: 10.1016/j.cardfail.2025.01.022
Saad Ahmed Waqas, Muhammad Umer Sohail, Muhammad Saad, Abdul Mannan Khan Minhas, Stephen J Greene, Marat Fudim, Gregg C Fonarow, Dmitry Abramov, Muhammad Shahzeb Khan, Raheel Ahmed

Background: Heart failure (HF) with mildly reduced or preserved ejection fraction (HFpEF) accounts for over half of cases of HF, with obesity playing a key role. Residual risk remains high despite available therapies. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential cardiometabolic benefits, but their role in HFpEF remains unclear.

Methods: A systematic review and meta-analysis of randomized controlled trials evaluating GLP-1RAs in HFpEF were conducted. Studies evaluating GLP-1RA in combination with glucose-dependent insulinotropic polypeptide (GIP) were also included. The analyzed outcomes included cardiovascular (CV) death, worsening HF events and their composite. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by using a random-effects model.

Results: Six randomized controlled trials involving 8788 patients were included. GLP-1RAs significantly reduced the composite outcome of CV death or worsening HF events (HR: 0.68 [0.51-0.89]; P = 0.006, I² = 47%) as well as worsening HF events alone (HR: 0.56 [0.38-0.82]; P = 0.003, I² = 51%). No significant reduction was observed for CV death alone (HR: 0.86 [0.67-1.12]; P = 0.27, I² = 0%).

Conclusion: GLP-1RAs reduce worsening HF events and the composite of CV death or worsening HF in HFpEF, particularly in patients with obesity or diabetes. These findings support their role as a promising therapy requiring further HFpEF-focused trials.

{"title":"Efficacy of GLP-1 Receptor Agonists in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.","authors":"Saad Ahmed Waqas, Muhammad Umer Sohail, Muhammad Saad, Abdul Mannan Khan Minhas, Stephen J Greene, Marat Fudim, Gregg C Fonarow, Dmitry Abramov, Muhammad Shahzeb Khan, Raheel Ahmed","doi":"10.1016/j.cardfail.2025.01.022","DOIUrl":"10.1016/j.cardfail.2025.01.022","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) with mildly reduced or preserved ejection fraction (HFpEF) accounts for over half of cases of HF, with obesity playing a key role. Residual risk remains high despite available therapies. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential cardiometabolic benefits, but their role in HFpEF remains unclear.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of randomized controlled trials evaluating GLP-1RAs in HFpEF were conducted. Studies evaluating GLP-1RA in combination with glucose-dependent insulinotropic polypeptide (GIP) were also included. The analyzed outcomes included cardiovascular (CV) death, worsening HF events and their composite. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by using a random-effects model.</p><p><strong>Results: </strong>Six randomized controlled trials involving 8788 patients were included. GLP-1RAs significantly reduced the composite outcome of CV death or worsening HF events (HR: 0.68 [0.51-0.89]; P = 0.006, I² = 47%) as well as worsening HF events alone (HR: 0.56 [0.38-0.82]; P = 0.003, I² = 51%). No significant reduction was observed for CV death alone (HR: 0.86 [0.67-1.12]; P = 0.27, I² = 0%).</p><p><strong>Conclusion: </strong>GLP-1RAs reduce worsening HF events and the composite of CV death or worsening HF in HFpEF, particularly in patients with obesity or diabetes. These findings support their role as a promising therapy requiring further HFpEF-focused trials.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and Outcomes of Patients With Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-17 DOI: 10.1016/j.cardfail.2025.01.019
Anthony P Carnicelli, P Elliott Miller, David D Berg, Nijat Aliyev, Carlos L Alviar, Erin A Bohula, Sunit-Preet Chaudhry, Meshe Chonde, Christine Chow, Howard A Cooper, Lori B Daniels, Christopher B Fordyce, Shahab Ghafghazi, Michael J Goldfarb, Kari L Gorder, Madeleine M Hamilton, Ryan R Keane, Michael C Kontos, Jonathan J Kusner, Evan Leibner, Daniel B Loriaux, Venu Menon, Raunak M Nair, L Kristin Newby, Mary-Tiffany Oduah, Michael G Palazzolo, Harsh Patolia, Jacob B Pierce, Matthew J Pierce, Brian J Potter, Alastair Proudfoot, Robert O Roswel, Gregory Schnell, Jeffrey Shaw, Kiran Sidhu, Shashank S Sinha, Anubodh S Varshney, Jason N Katz, Sean VAN Diepen, David A Morrow

Background: Cardiogenic shock (CS) can be complicated by severe valvular heart disease (VHD). We analyzed cardiac intensive care unit (CICU) admissions according to VHD status.

Methods and results: The Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs. Centers contributed data from consecutive admissions during 2-month annual snapshots from 2017-2023. CS admissions were classified as having CS attributed to VHD, CS with noncausative VHD or CS without severe VHD. Demographics and therapies were compared. Unadjusted and adjusted odds ratios for in-hospital mortality were calculated. We analyzed 5242 admissions with CS (4.1% attributed to VHD, 18.8% with noncausative VHD, 77.1% without severe VHD). Mitral regurgitation (32.1%) and aortic stenosis (27.9%) were the most common pathologies in CS attributed to VHD. Admissions with CS attributed to VHD more commonly had LVEF ≥ 40% on admission (present in 62.8%, 22.6% and 15.1%, respectively; P < 0.001). Valve intervention was performed in 32.1% of those with CS attributed to VHD. Unadjusted in-hospital mortality in admissions with CS attributed to VHD was 40.0%, compared to 33.4% and 30.3% in the other groups.

Conclusions: VHD is the underlying cause of CS in a minority of CICU admissions but is associated with high in-hospital mortality rates.

{"title":"Characteristics and Outcomes of Patients With Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network.","authors":"Anthony P Carnicelli, P Elliott Miller, David D Berg, Nijat Aliyev, Carlos L Alviar, Erin A Bohula, Sunit-Preet Chaudhry, Meshe Chonde, Christine Chow, Howard A Cooper, Lori B Daniels, Christopher B Fordyce, Shahab Ghafghazi, Michael J Goldfarb, Kari L Gorder, Madeleine M Hamilton, Ryan R Keane, Michael C Kontos, Jonathan J Kusner, Evan Leibner, Daniel B Loriaux, Venu Menon, Raunak M Nair, L Kristin Newby, Mary-Tiffany Oduah, Michael G Palazzolo, Harsh Patolia, Jacob B Pierce, Matthew J Pierce, Brian J Potter, Alastair Proudfoot, Robert O Roswel, Gregory Schnell, Jeffrey Shaw, Kiran Sidhu, Shashank S Sinha, Anubodh S Varshney, Jason N Katz, Sean VAN Diepen, David A Morrow","doi":"10.1016/j.cardfail.2025.01.019","DOIUrl":"10.1016/j.cardfail.2025.01.019","url":null,"abstract":"<p><strong>Background: </strong>Cardiogenic shock (CS) can be complicated by severe valvular heart disease (VHD). We analyzed cardiac intensive care unit (CICU) admissions according to VHD status.</p><p><strong>Methods and results: </strong>The Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs. Centers contributed data from consecutive admissions during 2-month annual snapshots from 2017-2023. CS admissions were classified as having CS attributed to VHD, CS with noncausative VHD or CS without severe VHD. Demographics and therapies were compared. Unadjusted and adjusted odds ratios for in-hospital mortality were calculated. We analyzed 5242 admissions with CS (4.1% attributed to VHD, 18.8% with noncausative VHD, 77.1% without severe VHD). Mitral regurgitation (32.1%) and aortic stenosis (27.9%) were the most common pathologies in CS attributed to VHD. Admissions with CS attributed to VHD more commonly had LVEF ≥ 40% on admission (present in 62.8%, 22.6% and 15.1%, respectively; P < 0.001). Valve intervention was performed in 32.1% of those with CS attributed to VHD. Unadjusted in-hospital mortality in admissions with CS attributed to VHD was 40.0%, compared to 33.4% and 30.3% in the other groups.</p><p><strong>Conclusions: </strong>VHD is the underlying cause of CS in a minority of CICU admissions but is associated with high in-hospital mortality rates.</p>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Heart Failure Physicians in the Contemporary Cardiac Intensive Care Unit: Impact on Heart Failure as a Career Choice Among Fellowship Applicants.
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-02-13 DOI: 10.1016/j.cardfail.2025.02.006
Nir Uriel, Justin Fried, Adil Yunis, Kevin Clerkin, Dor Lotan, Boaz Elad, Nancy Kelly, Jayant Raikhelkar, Daniel Burkhoff, Martin Leon, Manreet K Kanwar, Gabriel T Sayer
{"title":"The Role of Heart Failure Physicians in the Contemporary Cardiac Intensive Care Unit: Impact on Heart Failure as a Career Choice Among Fellowship Applicants.","authors":"Nir Uriel, Justin Fried, Adil Yunis, Kevin Clerkin, Dor Lotan, Boaz Elad, Nancy Kelly, Jayant Raikhelkar, Daniel Burkhoff, Martin Leon, Manreet K Kanwar, Gabriel T Sayer","doi":"10.1016/j.cardfail.2025.02.006","DOIUrl":"10.1016/j.cardfail.2025.02.006","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Cardiac Failure
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1