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Journal of Cardiac Failure最新文献

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How Much Alcohol Is too Much for the Heart? 多少酒精对心脏有害?
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-18 DOI: 10.1016/j.cardfail.2024.10.005
Belén Peiró-Aventín, Fernando Domínguez
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引用次数: 0
Natriuretic Peptides For Diagnosing Heart Stress: Taking Action Now. 用于诊断心脏压力的 Natriuretic Peptides:立即行动。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-18 DOI: 10.1016/j.cardfail.2024.10.004
Enrique Santas, Antoni Bayes-Genís, Julio Núñez
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引用次数: 0
Assessment of Revascularization Preferences With Best-Worst Scaling Among Patients With Ischemic Heart Disease. 用最佳-最差比例评估缺血性心脏病患者的血管重建偏好。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.1016/j.cardfail.2024.10.006
Amrita Mukhopadhyay, Victoria Vaughan Dickson, Aisha Langford, John A Spertus, Sripal Bangalore, Yan Zhang, Thaddeus Tarpey, Judith Hochman, Stuart D Katz
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引用次数: 0
Physiologic Pacing for the Prevention and Treatment of Heart Failure A State-of-the-Art Review. 用于预防和治疗心力衰竭的生理起搏技术现状综述》(Physiologic Pacing for the Prevention and Treatment of Heart Failure A State-of-the-Art Review)。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-15 DOI: 10.1016/j.cardfail.2024.08.063
Margaret Infeld, Jamie A Cyr, Damián Sánchez-Quintana, Christopher Madias, James E Udelson, Daniel L Lustgarten, Markus Meyer

Permanent pacing from the right ventricular apex can reduce quality of life and increase the risk of heart failure and death. This review summarizes the milestones in the evolution of pacemakers towards "physiologic pacing" with biventricular pacing systems and lead implantation into the cardiac conduction system to synchronize cardiac contraction and relaxation. Both approaches aim to reproduce normal cardiac activation and help prevent and treat heart failure. This review introduces the basic concepts and clinical evidence and discusses practical uses of physiological pacing.

从右心室心尖进行永久起搏会降低生活质量,增加心力衰竭和死亡的风险。本综述总结了起搏器向 "生理性起搏 "发展的里程碑,包括双心室起搏系统和将导联植入心脏传导系统以同步心脏收缩和舒张。这两种方法都旨在重现正常的心脏激活,帮助预防和治疗心力衰竭。本综述介绍了生理起搏的基本概念和临床证据,并讨论了生理起搏的实际应用。
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引用次数: 0
Cardio-Oncology and Heart Failure: a Scientific Statement From the Heart Failure Society of America. 心脏肿瘤学与心力衰竭:美国心力衰竭协会的科学声明。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-15 DOI: 10.1016/j.cardfail.2024.08.045
Michelle Weisfelner Bloom, Jacqueline B Vo, Jo E Rodgers, Alana M Ferrari, Anju Nohria, Anita Deswal, Richard K Cheng, Michelle M Kittleson, Jenica N Upshaw, Nicolas Palaskas, Anne Blaes, Sherry-Ann Brown, Bonnie Ky, Daniel Lenihan, Mathew S Maurer, Anecita Fadol, Kerry Skurka, Christine Cambareri, Cynthia Chauhan, Ana Barac

Heart failure and cancer remain 2 of the leading causes of morbidity and mortality, and the 2 disease entities are linked in a complex manner. Patients with cancer are at increased risk of cardiovascular complications related to the cancer therapies. The presence of cardiomyopathy or heart failure in a patient with new cancer diagnosis portends a high risk for adverse oncology and cardiovascular outcomes. With the rapid growth of cancer therapies, many of which interfere with cardiovascular homeostasis, heart failure practitioners need to be familiar with prevention, risk stratification, diagnosis, and management strategies in cardio-oncology. This Heart Failure Society of America statement addresses the complexities of heart failure care among patients with active cancer diagnoses and cancer survivors. Risk stratification, monitoring and management of cardiotoxicity are presented across stages A through D heart failure, with focused discussion on heart failure with preserved ejection fraction and special populations, such as survivors of childhood and young-adulthood cancers. We provide an overview of the shared risk factors between cancer and heart failure, highlighting heart failure as a form of cardiotoxicity associated with many different cancer therapeutics. Finally, we discuss disparities in the care of patients with cancer and cardiac disease and present a framework for a multidisciplinary-team approach and critical collaboration among heart failure, oncology, palliative care, pharmacy, and nursing teams in the management of these complex patients.

心力衰竭和癌症仍然是发病率和死亡率的两大主要原因,这两种疾病之间存在着复杂的联系。癌症患者因癌症治疗而出现心血管并发症的风险增加。新确诊癌症的患者出现心肌病或心力衰竭,预示着肿瘤和心血管不良后果的高风险。随着癌症疗法的快速发展,其中许多疗法都会干扰心血管平衡,因此心衰从业人员需要熟悉心肿瘤学的预防、风险分层、诊断和管理策略。美国心力衰竭协会的这份声明探讨了正在进行癌症诊断的患者和癌症幸存者中心力衰竭护理的复杂性。我们介绍了 A 至 D 期心力衰竭的风险分层、监测和心脏毒性管理,并重点讨论了射血分数保留型心力衰竭以及儿童和青少年癌症幸存者等特殊人群。我们概述了癌症与心力衰竭之间的共同风险因素,强调心力衰竭是一种与多种不同癌症疗法相关的心脏毒性。最后,我们讨论了癌症和心脏病患者护理中的差异,并提出了一个多学科团队方法框架,以及心力衰竭、肿瘤学、姑息治疗、药学和护理团队在管理这些复杂患者时的重要合作。
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引用次数: 0
Cardio-Oncology and Heart Failure: AL Amyloidosis for the Heart Failure Clinician: a Supplement to the Scientific Statement from the Heart Failure Society of America. 心脏肿瘤学与心力衰竭:美国心力衰竭协会科学声明的补充。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-15 DOI: 10.1016/j.cardfail.2024.08.046
Michelle Weisfelner Bloom, Jacqueline B Vo, Jo E Rodgers, Alana M Ferrari, Anju Nohria, Anita Deswal, Richard K Cheng, Michelle M Kittleson, Jenica N Upshaw, Nicolas Palaskas, Anne Blaes, Sherry-Ann Brown, Bonnie Ky, Daniel Lenihan, Mathew S Maurer, Anecita Fadol, Kerry Skurka, Christine Cambareri, Ana Barac
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引用次数: 0
Can't Rain on Our Parade: Highlights from the Heart Failure Society of America (HFSA) Annual Scientific Meeting 2024. 我们的游行不能下雨:美国心力衰竭协会(HFSA)2024 年科学年会花絮。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1016/j.cardfail.2024.10.001
Alexander G Hajduczok, Elena M Donald, Jennifer Maning, Quentin Youmans, Nosheen Reza
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引用次数: 0
COUNTERPOINT: Abandon or Reassess? Interpreting Treatment Effects in "Negative" Clinical Trials. 反驳:放弃还是重新评估?解读 "阴性 "临床试验中的治疗效果。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-04 DOI: 10.1016/j.cardfail.2024.09.007
Jessica R Overbey, Shelley Zieroth, Kert Viele
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引用次数: 0
FINEARTS Restoration: Revisiting the Role of Steroidal Mineralocorticoid Receptor Antagonists in Heart Failure with Mildly Reduced or Preserved Ejection Fraction Following FINEARTS-HF. FINEARTS 恢复:重新审视类固醇类矿物皮质激素受体拮抗剂在 FINEARTS-HF 后射血分数轻度降低或保留的心力衰竭患者中的作用。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-04 DOI: 10.1016/j.cardfail.2024.09.011
Ricky D Turgeon, Craig J Beavers
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引用次数: 0
The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry 心源性休克中康瑞洛的使用:CAMEO 登记的启示。
IF 6.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-01 DOI: 10.1016/j.cardfail.2024.08.003
JENNIFER RYMER MD, MBA, MHS , CAYLA PICHAN MD , COURTNEY PAGE MA , BROOKE ALHANTI PhD , DEEPAK L. BHATT MD, MPH, MBA , AJAR KOCHAR MD, MHS , DOMINICK J. ANGIOLILLO MD, PhD , MIGUEL DIAZ MD , NEIL J. WIMMER MD, MSc , RON WAKSMAN MD , LAWRENCE ANG MD , RICHARD BACH MD , RONALD JENKINS MD , HIJRAH EL-SABAE PharmD , LEO BROTHERS MPH , E. MAGNUS OHMAN MBBCh , W. SCHUYLER JONES MD , JEFFREY B. WASHAM PharmD , TRACY Y. WANG MD, MHS, MSc , DENNIS NARCISSE MD , MIR B. BASIR DO

Introduction

Little is known about the use of cangrelor in patients with myocardial infarction (MI) presenting with cardiogenic shock (CS).

Methods

CAMEO (Cangrelor in Acute MI: Effectiveness and Outcomes) is a multicenter observational registry evaluating platelet inhibition in patients with MI. We examined the duration of cangrelor infusion and the amount of time to transition from cangrelor to an oral P2Y12 inhibitor in patients with CS. We also assessed major adverse cardiovascular events (MACEs) and bleeding risks, stratified by dosage duration, time to transition and oral P2Y12 inhibitor potency.

Results

Among 2352 cangrelor-treated patients with MI, 249 patients were in CS. Among the patients with CS, 16 (6.4%) received the “bridge” infusion dose, 202 (81.1%) the PCI cangrelor infusion dose, and 30 (12.0%) had a combination of both infusion doses. Patients with CS had a median age of 66 years; 32% were women; 21% were Black patients; 35% had diabetes; 19% received thrombectomy; and 59% received mechanical circulatory support (MCS) (35% intra-aortic balloon pump, 27% Impella). The median duration of infusion was 3.9 (2–21.5 hours) in patients with CS and was 2 (1.6–3.1 hours) for all cangrelor-treated patients. The median duration of transition from cangrelor to oral P2Y12 inhibitor administration was 0.1 (-0.5–21.0 hours) for patients with CS. In multivariable modeling, chronic lung disease and the use of MCS and was associated with longer cangrelor infusions (defined as > 3.9 hours). Among cangrelor-treated patients with CS, 24.1% of these patients had a bleeding event, and 41.8% had a MACE event. After adjustment, a longer cangrelor infusion duration was associated with increased risk of bleeding (P < 0.05).

Conclusions

The median duration of cangrelor infusion was longer for patients presenting with CS. Use of MCS was associated with longer cangrelor infusion durations in patients with CS. Further work is needed to understand the pharmacodynamics of antiplatelet agents in patients with CS.
简介人们对心肌梗死(MI)伴有心源性休克(CS)的患者使用坎格雷洛的情况知之甚少:CAMEO(坎格列罗在急性心肌梗死中的应用:疗效与结果)是一项多中心观察登记项目,旨在评估心肌梗死患者的血小板抑制情况。我们研究了CS患者输注坎格雷罗的持续时间以及从坎格雷罗过渡到口服P2Y12抑制剂的时间。我们还评估了主要心血管不良事件(MACEs)和出血风险,并根据剂量持续时间、过渡时间和口服 P2Y12 抑制剂的效力进行了分层:在2352例接受坎格雷乐治疗的心肌梗死患者中,有249例为CS患者。在CS患者中,16人(6.4%)接受了 "桥接 "输注剂量,202人(81.1%)接受了PCI坎格雷洛输注剂量,30人(12.0%)同时接受了两种输注剂量。CS患者的中位年龄为66岁;32%为女性;21%为黑人患者;35%患有糖尿病;19%接受了血栓切除术;59%接受了机械循环支持(MCS)(35%主动脉内球囊泵,27%Impella)。CS患者的中位输液持续时间为3.9(2-21.5小时),所有接受坎格雷乐治疗的患者的中位输液持续时间为2(1.6-3.1小时)。CS患者从服用康格列转为口服P2Y12抑制剂的中位持续时间为0.1(-0.5-21.0小时)。在多变量模型中,慢性肺部疾病和使用 MCS 与更长时间的坎格雷洛输注(定义为 > 3.9 小时)相关。在接受坎格雷乐治疗的 CS 患者中,24.1% 的患者发生了出血事件,41.8% 的患者发生了 MACE 事件。经调整后,坎格雷洛输注持续时间越长,出血风险越高(P<0.05):结论:CS患者坎格雷洛输注的中位持续时间更长。CS患者使用MCS与更长的坎格雷洛输注时间有关。还需要进一步研究以了解 CS 患者使用抗血小板药物的药效学。
{"title":"The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry","authors":"JENNIFER RYMER MD, MBA, MHS ,&nbsp;CAYLA PICHAN MD ,&nbsp;COURTNEY PAGE MA ,&nbsp;BROOKE ALHANTI PhD ,&nbsp;DEEPAK L. BHATT MD, MPH, MBA ,&nbsp;AJAR KOCHAR MD, MHS ,&nbsp;DOMINICK J. ANGIOLILLO MD, PhD ,&nbsp;MIGUEL DIAZ MD ,&nbsp;NEIL J. WIMMER MD, MSc ,&nbsp;RON WAKSMAN MD ,&nbsp;LAWRENCE ANG MD ,&nbsp;RICHARD BACH MD ,&nbsp;RONALD JENKINS MD ,&nbsp;HIJRAH EL-SABAE PharmD ,&nbsp;LEO BROTHERS MPH ,&nbsp;E. MAGNUS OHMAN MBBCh ,&nbsp;W. SCHUYLER JONES MD ,&nbsp;JEFFREY B. WASHAM PharmD ,&nbsp;TRACY Y. WANG MD, MHS, MSc ,&nbsp;DENNIS NARCISSE MD ,&nbsp;MIR B. BASIR DO","doi":"10.1016/j.cardfail.2024.08.003","DOIUrl":"10.1016/j.cardfail.2024.08.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Little is known about the use of cangrelor in patients with myocardial infarction (MI) presenting with cardiogenic shock (CS).</div></div><div><h3>Methods</h3><div>CAMEO (Cangrelor in Acute MI: Effectiveness and Outcomes) is a multicenter observational registry evaluating platelet inhibition in patients with MI. We examined the duration of cangrelor infusion and the amount of time to transition from cangrelor to an oral P2Y<sub>12</sub> inhibitor in patients with CS. We also assessed major adverse cardiovascular events (MACEs) and bleeding risks, stratified by dosage duration, time to transition and oral P2Y<sub>12</sub> inhibitor potency.</div></div><div><h3>Results</h3><div>Among 2352 cangrelor-treated patients with MI, 249 patients were in CS. Among the patients with CS, 16 (6.4%) received the “bridge” infusion dose, 202 (81.1%) the PCI cangrelor infusion dose, and 30 (12.0%) had a combination of both infusion doses. Patients with CS had a median age of 66 years; 32% were women; 21% were Black patients; 35% had diabetes; 19% received thrombectomy; and 59% received mechanical circulatory support (MCS) (35% intra-aortic balloon pump, 27% Impella). The median duration of infusion was 3.9 (2–21.5 hours) in patients with CS and was 2 (1.6–3.1 hours) for all cangrelor-treated patients. The median duration of transition from cangrelor to oral P2Y<sub>12</sub> inhibitor administration was 0.1 (-0.5–21.0 hours) for patients with CS. In multivariable modeling, chronic lung disease and the use of MCS and was associated with longer cangrelor infusions (defined as &gt; 3.9 hours). Among cangrelor-treated patients with CS, 24.1% of these patients had a bleeding event, and 41.8% had a MACE event. After adjustment, a longer cangrelor infusion duration was associated with increased risk of bleeding (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The median duration of cangrelor infusion was longer for patients presenting with CS. Use of MCS was associated with longer cangrelor infusion durations in patients with CS. Further work is needed to understand the pharmacodynamics of antiplatelet agents in patients with CS.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"30 10","pages":"Pages 1233-1240"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of Cardiac Failure
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