Journal of Cardiac Failure最新文献

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Between Two Signals: The Intersection of Electrophysiology and Heart Failure 两个信号之间：电生理学和心力衰竭的交叉。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-09-27 DOI: 10.1016/j.cardfail.2025.09.015

Jose Lopez MD

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Comparative Outcomes of Tirzepatide and Semaglutide in Patients With Heart Failure With Preserved Ejection Fraction and Type 2 Diabetes 替西帕肽和西马鲁肽在保留射血分数和2型糖尿病心力衰竭患者中的比较疗效。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-09-12 DOI: 10.1016/j.cardfail.2025.07.026

TAKEFUMI KISHIMORI M.D. , TAKAO KATO M.D., Ph.D. , ATSUYUKI WADA M.D., Ph.D. , AKIRA TANI M.D. , RYOSUKE YAMAJI M.D. , JUMPEI KOIKE M.D. , YOSHIHIRO IWASAKI M.D., Ph.D. , TAKEHIRO MATSUMOTO M.D., Ph.D. , TAKAFUMI YAGI M.D. , MASAHARU OKADA M.D., Ph.D.

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JCF: In Case You Missed it! Summary of HFSA 2025 JCF：以防你错过了！HFSA 2025摘要。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-10-29 DOI: 10.1016/j.cardfail.2025.10.002

STEPHANIE GOLOB MD , ELENA DONALD MD , MARIA ROSA COSTANZO MD

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The Creative Academic Leader: Six Attributes That Shape Discovery, Integrity, and Impact 创造性学术领袖塑造发现、诚信和影响力的六个属性。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-11-06 DOI: 10.1016/j.cardfail.2025.10.010

MANDEEP R. MEHRA M.D., M.Sc. , MILICA VUKIĆEVIĆ M.D. , ANDREAS ZUCKERMANN M.D.

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Letter to the Editor Reply: “The Advanced Heart Failure Workforce Crisis: A Path Forward” 致编辑的回信：“心力衰竭劳动力危机：前进之路”。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1016/j.cardfail.2025.11.472

EIRAN Z. GORODESKI MD, MPH , SHASHANK SHEKHAR MD , ROBERT A. MONTGOMERY MD

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The Advanced Heart Failure Workforce Crisis: A Path Forward 晚期心力衰竭劳动力危机：前进之路。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1016/j.cardfail.2025.10.018

MAYA GUGLIN M.D., Ph.D.

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Have We Been Overlooking Lipoprotein(a) in Heart Failure? 我们是否忽视了心力衰竭中的脂蛋白(a) ？

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-11-24 DOI: 10.1016/j.cardfail.2025.11.484

LAURA AGUILAR FRANCO MD, MPH , AMY L. ZHANG MD , A. RESHAD GARAN MD, MSc

引用次数: 0

Health Literacy and Physical Function Among Older Black and Hispanic Individuals With Heart Failure 老年黑人和西班牙裔心力衰竭患者的健康素养和身体功能

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-07-12 DOI: 10.1016/j.cardfail.2025.06.010

SHABATUN J. ISLAM MD , SERGIO TERUYA MD, MS , DENISE FINE BS , NATALIA SABOGAL BS , SERGYLENSKY FILS BS , IKRAM ULLAH MD , ANYA SANCHORAWALA BS , EDWARD MILLER MD , CESIA GALLEGOS MD , CINTHIA DE FREITAS RN , DAMIAN KURIAN MD , NATALIA IONESCU PA , IVROSE JANVIER PA , FARBOD RAISZADEH MD, PhD , EMELIA J. BENJAMIN MD, ScM , JARED W. MAGNANI MD, MSc , MATHEW S. MAURER MD , FREDERICK L. RUBERG MD

Background

Insufficient health literacy negatively impacts outcomes for heart failure (HF). Older adults with HF face significant barriers, including prevalence of multiple comorbidities, frailty and deficits in physical function, which can impact HF outcomes. Examination of the association between health literacy and physical function remains limited in older adults with HF. We investigated the cross-sectional associations of health literacy and physical function in a cohort of older self-identified Black and Hispanic patients with HF.

Methods and Results

The Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations (SCAN-MP) study recruited participants (age ≥ 60 years) of self-identified Black race or Hispanic ethnicity in New York City, Boston and New Haven. We measured health literacy by using the Newest Vital Sign, and we measured physical function by using the 6-minute walk duration (6MWD) and the Short Physical Performance Battery test (SPPB). Linear regression models evaluated the association between participants’ health-literacy levels and physical function, as defined by continuous measures of 6MWD and SPPB. Only 12.7% of the cohort (n = 433) had adequate health literacy. After adjusting for age, sex, number of comorbidities, and neighborhood social vulnerability, those with adequate (compared to limited) health literacy demonstrated better performance on the 6MWD (β = 37.5 m, 95% CI [1.49, 73.5]; P = 0.04) and SPPB (β = 1.18 (0.41, 1.95); P = 0.002).

Conclusion

Older Black or Hispanic participants with HF have an extremely high prevalence of limited health literacy, which is associated with poor physical function. Interventions targeting health literacy may represent an avenue to improve HF outcomes for patients with minoritized backgrounds.

背景：健康素养不足会对心力衰竭（HF）的预后产生负面影响。老年HF患者面临重大障碍，包括多种合并症的流行、虚弱和身体功能缺陷，这些都可能影响HF的结局。对老年心衰患者健康素养与身体功能之间关系的研究仍然有限。我们调查了一组自认为是黑人和西班牙裔的老年心衰患者的健康素养和身体功能的横断面关联。方法与结果：在少数人群中使用核成像筛查心脏淀粉样变性（SCAN-MP）研究在纽约市、波士顿和纽黑文招募了自认为是黑人或西班牙裔的参与者（年龄0 - 60岁）。我们使用最新生命体征测量健康素养，使用6分钟步行时间（6MWD）和短物理性能电池测试（SPPB）测量身体功能。线性回归模型通过连续测量6MWD和SPPB来评估参与者的健康素养水平与身体功能之间的关系。只有12.7%的队列（n=433）有足够的健康素养。在调整了年龄、性别、合共病数量和社区社会脆弱性后，健康素养较好的人群在6MWD （β=37.5 m, 95% CI [1.49, 73.5], p=0.04）和SPPB （β=1.18 (0.41, 1.95), p=0.002）上表现更好。结论：老年黑人或西班牙裔HF患者健康素养有限的患病率极高，这与身体功能差有关。针对健康素养的干预措施可能是改善少数族裔心衰患者预后的一种途径。

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引用次数: 0

Lipoprotein(a) Levels and Adverse Outcomes in Heart Failure 心力衰竭患者脂蛋白(a)水平和不良结局。

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 Epub Date: 2025-04-04 DOI: 10.1016/j.cardfail.2025.03.016

ADITHYA K. YADALAM MD, MSc , APOORVA GANGAVELLI MD, MSc , ALEXANDER C. RAZAVI MD, MPH, PhD , YI-AN KO PhD , AYMAN ALKHODER MD , NISREEN HAROUN MD , RAFIA LODHI MBBS , AHMED ELDAIDAMOUNI MBBCh , MAHMOUD AL KASEM MD , ARSHED A. QUYYUMI MD

Background

Although lipoprotein(a) [Lp(a)] level elevation is associated with new-onset heart failure (HF), it is unclear if elevated Lp(a) levels predict cardiovascular events in patients with chronic HF. Thus, we examined the association between Lp(a) levels and adverse cardiovascular outcomes in patients with HF.

Methods and Results

A total of 1088 patients with HF undergoing cardiac catheterization at Emory-affiliated hospitals from 2004 to 2022 were divided into low (<30 mg/dL), intermediate (30–49 mg/dL), and high (≥50 mg/dL) Lp(a) groups. The primary outcome was the composite of cardiovascular death and HF hospitalization. Outcomes were assessed by Lp(a) group with competing risk modeling accounting for noncardiovascular death after adjustment for demographics, traditional cardiovascular risk factors, ejection fraction, ischemic HF etiology, and N-terminal prohormone of brain natriuretic peptide. Sensitivity analyses were performed to explore for heterogeneity of effect. The median age was 67 years, 34% were women, 18% were Black, 74% had ischemic HF, and 60% had an ejection fraction of ≤40%. During a median follow-up time of 4.3 years, 474 composite events (44%) occurred. When compared with participants with Lp(a) <30 mg/dL after multivariable adjustment, those with Lp(a) 30-49 mg/dL (subdistribution hazard ratio [sHR] 1.35, 95% confidence interval 1.04–1.76, P = .025) and Lp(a) ≥50 mg/dL (sHR 1.38, 95% confidence interval 1.11–1.72, P = .004) had a significantly higher risk of cardiovascular death or HF hospitalization. This relationship seemed to diminish over time and was nominally stronger in those with ischemic versus nonischemic HF (P_interaction = .06), but did not meet significance after adjustment for multiple hypothesis testing.

Conclusions

In patients with HF, Lp(a) ≥30 mg/dL independently predicts the risk of cardiovascular death or HF hospitalization.

背景：虽然脂蛋白(a) [Lp(a)]水平升高与新发心力衰竭（HF）相关，但目前尚不清楚Lp(a)水平升高是否能预测慢性心力衰竭患者的心血管事件。因此，我们研究了心衰患者Lp(a)水平与不良心血管结局之间的关系。方法与结果：将2004 - 2022年在emory附属医院行心导管术的1088例HF患者分为低组(结论：在HF患者中，Lp(A)≥30 mg/dL独立预测心血管死亡或HF住院的风险。

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Association Between Baseline Hypertension and Longitudinal Functional Status in Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten. 马伐卡坦治疗梗阻性肥厚性心肌病患者基线高血压与纵向功能状态的关系

IF 8.2 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure

Pub Date : 2026-02-01 DOI: 10.1016/j.cardfail.2025.12.010

Nosheen Reza, Nadim Mahmud, Melissa A Austin, Ellen Boakye, Estherland Duqueney, Parth Patel, Alejandro DE Feria, Nicole Hornsby, Amy Marzolf, Anjali Tiku Owens

Hypertension is common in hypertrophic cardiomyopathy (HCM) yet its impact on patients on long-term mavacamten is unknown. In this single-center observational study of 163 patients with symptomatic obstructive HCM treated with mavacamten for up to 108 weeks, hemodynamic and functional responses stratified by baseline hypertension status (60.7% hypertensive) were compared. Mavacamten produced similar reductions in resting and Valsalva LVOT gradients regardless of hypertension status. However, patients with hypertension had a significantly lower probability of achieving NYHA Class I functional status over time (interaction p=0.01). These findings suggest that hypertension-related factors beyond LVOT obstruction may limit complete functional recovery in obstructive HCM despite effective gradient reduction with mavacamten.

高血压在肥厚性心肌病（HCM）中很常见，但其对长期服用马伐卡坦患者的影响尚不清楚。在这项单中心观察性研究中，163例症状性阻塞性HCM患者接受马伐卡坦治疗长达108周，比较了基线高血压状态（60.7%高血压）分层的血液动力学和功能反应。无论高血压状态如何，Mavacamten在静息和Valsalva LVOT梯度上均产生相似的降低。然而，随着时间的推移，高血压患者达到NYHA I级功能状态的概率显著降低（相互作用p=0.01）。这些研究结果表明，尽管马伐卡坦有效降低了LVOT的梯度，但除了LVOT阻塞之外，高血压相关因素可能限制梗阻性HCM的完全功能恢复。

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