{"title":"In Vivo Antioxidant Activity of Phyllanthus Emblicus against Cisplatin Induced Oxidative Stress in Mice","authors":"Mamuna Naz, U. Saleem, B. Ahmad","doi":"10.21065/19204159.8.1.1","DOIUrl":"https://doi.org/10.21065/19204159.8.1.1","url":null,"abstract":"","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81750586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-26DOI: 10.21065/1920-4159.1000231
M. Luisetto
The rationale of this works is to analyse relationship in field of poisoning and toxicology between pharmaceutical care approach in order to improve the global management of the system and improving clinical outcomes in high risk situations. Observing the roles played by clinical pharmacy in toxicology medical team we can have relevant improving in the management of the systems. Starting from the analysis of some relevant literature we submit to international organization a rethinking about the toxicological medical team organization with a stabile presence of clinical pharmacist. Poisoning therapy is a multidisciplinary bio- medical work and we have more benefit when clinical pharmacist is permanent member of toxicology team.
{"title":"Pharmaceutical Care and Toxicology, a Synergy in High Risk Situation","authors":"M. Luisetto","doi":"10.21065/1920-4159.1000231","DOIUrl":"https://doi.org/10.21065/1920-4159.1000231","url":null,"abstract":"The rationale of this works is to analyse relationship in field of poisoning and toxicology between pharmaceutical care approach in order to improve the global management of the system and improving clinical outcomes in high risk situations. Observing the roles played by clinical pharmacy in toxicology medical team we can have relevant improving in the management of the systems. Starting from the analysis of some relevant literature we submit to international organization a rethinking about the toxicological medical team organization with a stabile presence of clinical pharmacist. Poisoning therapy is a multidisciplinary bio- medical work and we have more benefit when clinical pharmacist is permanent member of toxicology team.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"69 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87211576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-08DOI: 10.21065/1920-4159.1000230
Khan Sa, R. Afridi, Afridi Uk, S. Sadozai
Background: The main strategy of analgesic therapy is to diminish the intensity of pain to bearable level. Guidelines have been established by WHO to reduce the possible medication error in analgesic therapy. However, in most of the hospitals in Pakistan, analgesics are not prescribed rationally in accordance with standard guidelines. Objectives: The purpose of this study is to analyze therapeutic strategy of pain management in patients hospitalized at a tertiary hospital, as an exemplary assessment of prescribing pattern of analgesics, and to estimate the prevalence of potential drug–drug interaction there in. Methodology: This is a non-interventional cross sectional study of patients hospitalized in surgical and oncology wards of an urban Pakistani tertiary care hospital. The prescriptions were analyzed for physicians' preferences for the choice of analgesics and number of analgesics prescribed. Moreover, general observation was made whether pain intensity assessment tools were employed before prescribing analgesics. The effectiveness of prescribed analgesics was assessed by interviewing the patients post analgesic therapy. Furthermore, potential drug–drug interactions were also studied using reference books and Medscape Multi Drug interaction checker. Results: In the study population of n=45 inpatient (24 male and 21 female). Tramadol was the most frequently prescribed analgesic. In none of the case pain intensity was assessed before prescribing analgesics, hence, 53.3% subjects complained about severe pain even after analgesic therapy. Potential drug–drug interactions were present in all the prescriptions. Ultimately, 276 interactions were found in 45 prescriptions, among which 60% were of major severity. Conclusion: In current study, poor management of pain was identified in a tertiary hospital in Pakistan. The analgesics were prescribed without actually assessing the pain intensity. Improper analgesic regimen was selected and too many interacting drugs were prescribed simultaneously.
{"title":"Prescribing Pattern and DrugâÂÂDrug Interactions of Analgesics Prescribed For Pain Management in a Pakistani Tertiary Hospital","authors":"Khan Sa, R. Afridi, Afridi Uk, S. Sadozai","doi":"10.21065/1920-4159.1000230","DOIUrl":"https://doi.org/10.21065/1920-4159.1000230","url":null,"abstract":"Background: The main strategy of analgesic therapy is to diminish the intensity of pain to bearable level. Guidelines have been established by WHO to reduce the possible medication error in analgesic therapy. However, in most of the hospitals in Pakistan, analgesics are not prescribed rationally in accordance with standard guidelines. Objectives: The purpose of this study is to analyze therapeutic strategy of pain management in patients hospitalized at a tertiary hospital, as an exemplary assessment of prescribing pattern of analgesics, and to estimate the prevalence of potential drug–drug interaction there in. Methodology: This is a non-interventional cross sectional study of patients hospitalized in surgical and oncology wards of an urban Pakistani tertiary care hospital. The prescriptions were analyzed for physicians' preferences for the choice of analgesics and number of analgesics prescribed. Moreover, general observation was made whether pain intensity assessment tools were employed before prescribing analgesics. The effectiveness of prescribed analgesics was assessed by interviewing the patients post analgesic therapy. Furthermore, potential drug–drug interactions were also studied using reference books and Medscape Multi Drug interaction checker. Results: In the study population of n=45 inpatient (24 male and 21 female). Tramadol was the most frequently prescribed analgesic. In none of the case pain intensity was assessed before prescribing analgesics, hence, 53.3% subjects complained about severe pain even after analgesic therapy. Potential drug–drug interactions were present in all the prescriptions. Ultimately, 276 interactions were found in 45 prescriptions, among which 60% were of major severity. Conclusion: In current study, poor management of pain was identified in a tertiary hospital in Pakistan. The analgesics were prescribed without actually assessing the pain intensity. Improper analgesic regimen was selected and too many interacting drugs were prescribed simultaneously.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"378 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77503435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-06DOI: 10.21065/1920-4159.1000229
M. Luisetto, B. Nili-Ahmadabadi
In hospital setting patients drug therapy are administered in continuous way: every night and day, every day in a year and in order to assure the continuity of a pharmacological treatment we have to make sure to have a pharmacy systems that provide drugs in continuous way. Background: When hospital pharmacies are closed night-time or during weekend, in order to provide emergency service or dispense drugs, a 24-h pharmacist service (or on call) have been often used. Several pharmacists may be involved in this kind of service, generally from 4 to 6, and this is a cost for some hospital and institutions or government. A solution to cut or reduce such cost as an alternative service, without any risk to the safety of patients can be an interesting innovation in today’s healthcare. Motivation: Often the cost is not the only problem; in addition to that, those long hours were putting the pharmacist under pressure in covering the service. If we decide to introduce new systems then the most important thing to cover all the emergency case is to choose a small list of the most important drugs to put in emergency cabinets in order to cover the most critical cases. Since the number of the drugs available in a hospital pharmacy is too big for a cabinet. Problem Statement: In this works, we analyze some article in biomedical database and guideline and we submit to the institution a management system to overtake the pharmacist. Presence during nighttime or in weekend, and were make also an economic evaluation in cost reducing using this system.
{"title":"Emergency Hospital Drug Cabinet Systems Managed by Hospital Pharmacists and ER Physicians: A Healthcare Management Model to Reduce Costs","authors":"M. Luisetto, B. Nili-Ahmadabadi","doi":"10.21065/1920-4159.1000229","DOIUrl":"https://doi.org/10.21065/1920-4159.1000229","url":null,"abstract":"In hospital setting patients drug therapy are administered in continuous way: every night and day, every day in a year and in order to assure the continuity of a pharmacological treatment we have to make sure to have a pharmacy systems that provide drugs in continuous way. Background: When hospital pharmacies are closed night-time or during weekend, in order to provide emergency service or dispense drugs, a 24-h pharmacist service (or on call) have been often used. Several pharmacists may be involved in this kind of service, generally from 4 to 6, and this is a cost for some hospital and institutions or government. A solution to cut or reduce such cost as an alternative service, without any risk to the safety of patients can be an interesting innovation in today’s healthcare. Motivation: Often the cost is not the only problem; in addition to that, those long hours were putting the pharmacist under pressure in covering the service. If we decide to introduce new systems then the most important thing to cover all the emergency case is to choose a small list of the most important drugs to put in emergency cabinets in order to cover the most critical cases. Since the number of the drugs available in a hospital pharmacy is too big for a cabinet. Problem Statement: In this works, we analyze some article in biomedical database and guideline and we submit to the institution a management system to overtake the pharmacist. Presence during nighttime or in weekend, and were make also an economic evaluation in cost reducing using this system.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"36 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87378267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-28DOI: 10.21065/1920-4159.1000228
M. Rupeshkumar, Upashna Chettri, S. Jaikumar, M. RathiBai, P. M. Paarakh
Ganoderma lucidum, commonly referred to as Lingzhi or Reishi, is a basidiomycete rot fungus which has been used for centuries in East Asia for promotion of good health and longevity. The main bioactive components of G. lucidum can be broadly grouped into polysaccharides and triterpenes. The anticancer properties of G. lucidum have been proved in both in vitro and in vivo studies using human and murine cell lines. Various pharmacological activities have been reported such as, hepatoprotective, anti-diabetic, anti-hypertensive, cardioprotective, immune modulatory, antioxidant, anticancer, etc. Regardless of polysaccharides and triterpenes have been used for treatment of different types of cancers the mechanism by which they exert their anticancer effect remains undefined. The aim of this paper is to summarise the treatment of various cancer with respect to various mechanisms that have been suggested for the anticancer properties of polysaccharides and triterpenes extracted from G. lucidum.
{"title":"Ganoderma lucidum: A Review with Special Emphasis on the Treatment of Various Cancer","authors":"M. Rupeshkumar, Upashna Chettri, S. Jaikumar, M. RathiBai, P. M. Paarakh","doi":"10.21065/1920-4159.1000228","DOIUrl":"https://doi.org/10.21065/1920-4159.1000228","url":null,"abstract":"Ganoderma lucidum, commonly referred to as Lingzhi or Reishi, is a basidiomycete rot fungus which has been used for centuries in East Asia for promotion of good health and longevity. The main bioactive components of G. lucidum can be broadly grouped into polysaccharides and triterpenes. The anticancer properties of G. lucidum have been proved in both in vitro and in vivo studies using human and murine cell lines. Various pharmacological activities have been reported such as, hepatoprotective, anti-diabetic, anti-hypertensive, cardioprotective, immune modulatory, antioxidant, anticancer, etc. Regardless of polysaccharides and triterpenes have been used for treatment of different types of cancers the mechanism by which they exert their anticancer effect remains undefined. The aim of this paper is to summarise the treatment of various cancer with respect to various mechanisms that have been suggested for the anticancer properties of polysaccharides and triterpenes extracted from G. lucidum.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"25 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72791058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Interest in herbal drugs is undergoing a renaissance at present time. Herbal agents are regarded to be more effective and comparatively safe as opposed to conventional medications which are relatively inaccessible and arguably associated with various adverse effects. Harrisonia abyssinica and Landolphia buchananii have been used by the Ameru and Embu communities to alleviate various ailments. However, despite their wide folklore use, extensive literature research reveals limited scientific evaluation of their described effects. Thus, the current study aimed to evaluate the antipyretic effects of their methanolic extracts. The plant samples were sourced from Mbeere, Embu County, Kenya. The test subjects (experimental rats) were grouped into four; normal group, a negative control group, reference group and experimental groups. The experimental groups were treated with stem bark extracts at concentration of 50 mg/kg, 100 mg/kg and 150 mg/kg. The determination of antipyretic activities was evaluated by using a 20% turpentine solution as the pyrexia inducing agent and then compared with aspirin as the reference drug. H. abyssinica extract reduced the rectal temperature by between 0.90% and 1.73% while L. buchananii extract reduced it by between 0.32% and 2.52%. Aspirin reduced the elevated rectal temperature by 1.70% and 2.32%. Qualitative phytochemical screening results showed that the extracts possessed several phytochemicals. The results of the study have confirmed the folklore use of the aforementioned plants in the suppression of pyrexia.
{"title":"Antipyretic potential of methanolic stem bark extracts of harrisonia abyssinica oliv and landolphia buchananii (hallier f.) stapf in wistar rats","authors":"Nthiga Pm, Kamau Jk, Safari Vz, Mwonjoria Jk, Mburu Dn, M. Ngugi","doi":"10.21065/1920-4159.1000227","DOIUrl":"https://doi.org/10.21065/1920-4159.1000227","url":null,"abstract":"Interest in herbal drugs is undergoing a renaissance at present time. Herbal agents are regarded to be more effective and comparatively safe as opposed to conventional medications which are relatively inaccessible and arguably associated with various adverse effects. Harrisonia abyssinica and Landolphia buchananii have been used by the Ameru and Embu communities to alleviate various ailments. However, despite their wide folklore use, extensive literature research reveals limited scientific evaluation of their described effects. Thus, the current study aimed to evaluate the antipyretic effects of their methanolic extracts. The plant samples were sourced from Mbeere, Embu County, Kenya. The test subjects (experimental rats) were grouped into four; normal group, a negative control group, reference group and experimental groups. The experimental groups were treated with stem bark extracts at concentration of 50 mg/kg, 100 mg/kg and 150 mg/kg. The determination of antipyretic activities was evaluated by using a 20% turpentine solution as the pyrexia inducing agent and then compared with aspirin as the reference drug. H. abyssinica extract reduced the rectal temperature by between 0.90% and 1.73% while L. buchananii extract reduced it by between 0.32% and 2.52%. Aspirin reduced the elevated rectal temperature by 1.70% and 2.32%. Qualitative phytochemical screening results showed that the extracts possessed several phytochemicals. The results of the study have confirmed the folklore use of the aforementioned plants in the suppression of pyrexia.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"58 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82078616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-15DOI: 10.21065/1920-4159.1000E113
M. Luisetto
In vitro diagnostic products management is needed because new innovative products are present in today laboratory (biomolecular lab, immunogenetic, immunohistochemistry) and many procedures need specialist reagent (PCR, MABS, DNA POLIMERASe and other). The specific competencies of clinical pharmacists also in diagnostic field and clinical chemistry, biochemistry, analytical chemistry are core business in hospital pharmacist core curriculum and we think in medical devices field.
体外诊断产品管理是必要的，因为新的创新产品出现在今天的实验室(生物分子实验室，免疫遗传学，免疫组织化学)和许多程序需要专业试剂(PCR, maabs, DNA POLIMERASe等)。临床药师在诊断、临床化学、生物化学、分析化学等领域的具体能力是医院药师核心课程的核心业务，我们认为在医疗器械领域也是如此。
{"title":"The Medical Devices Pharmacists Management Role and Pharmaceutical Care","authors":"M. Luisetto","doi":"10.21065/1920-4159.1000E113","DOIUrl":"https://doi.org/10.21065/1920-4159.1000E113","url":null,"abstract":"In vitro diagnostic products management is needed because new innovative products are present in today laboratory (biomolecular lab, immunogenetic, immunohistochemistry) and many procedures need specialist reagent (PCR, MABS, DNA POLIMERASe and other). The specific competencies of clinical pharmacists also in diagnostic field and clinical chemistry, biochemistry, analytical chemistry are core business in hospital pharmacist core curriculum and we think in medical devices field.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"34 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75855759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-28DOI: 10.21065/1920-4159.1000226
S. Huq, M. Ali, R. Islam, Farzana Manzoor, Imon Rahman
The study was designed to determine the phytochemical constituents and to evaluate several biological activities of crude methanol extracts of a native plant, Murdannia nudiflora, an exotic plant, Tradescantia pallida, and a common spice, Piper nigrum, as well as their organic soluble fractions. Preliminary phytochemical screening confirmed the presence of several secondary metabolites.The petroleum ether extract of P. nigrum exhibited the highest degree of cytotoxicity (LC50=3.524 μg/ml) whereas that of M. nudiflora and T. pallida were quite low. Antioxidant studies of the plant extracts yielded prominent results where the free radical scavenging potential of M. Nudiflora and T. Pallida were found to be 95.76 ± 1.34 mg/100g and 97.15 ± 0.96mg/100g of AAE, respectively, whereas, IC50 values of M. nudiflora and T. pallida were 1.51x10-10μg/ml and 4.209x10-13μg/ml, respectively, justifying the presence of high concentration of flavonoids. In addition, the analgesic studies of M. nudiflora and T. Pallida revealed significant inhibition of writhing upon induction of pain by acetic acid (p<0.001, p<0.05, respectively). The chloroform extract of P.nigrum showed 61.27% inhibition of hypotonic solution induced and 96.61% inhibition of heat induced haemolysis, while the methanolic extract of the plant produced 30.74% of clot lysis confirming a moderate thrombolytic activity. Thus, the present study strives to provide a scientific basis of the traditional uses of the medicinal plants.
{"title":"Biological Evaluation of Native and Exotic Plants of Bangladesh","authors":"S. Huq, M. Ali, R. Islam, Farzana Manzoor, Imon Rahman","doi":"10.21065/1920-4159.1000226","DOIUrl":"https://doi.org/10.21065/1920-4159.1000226","url":null,"abstract":"The study was designed to determine the phytochemical constituents and to evaluate several biological activities of crude methanol extracts of a native plant, Murdannia nudiflora, an exotic plant, Tradescantia pallida, and a common spice, Piper nigrum, as well as their organic soluble fractions. Preliminary phytochemical screening confirmed the presence of several secondary metabolites.The petroleum ether extract of P. nigrum exhibited the highest degree of cytotoxicity (LC50=3.524 μg/ml) whereas that of M. nudiflora and T. pallida were quite low. Antioxidant studies of the plant extracts yielded prominent results where the free radical scavenging potential of M. Nudiflora and T. Pallida were found to be 95.76 ± 1.34 mg/100g and 97.15 ± 0.96mg/100g of AAE, respectively, whereas, IC50 values of M. nudiflora and T. pallida were 1.51x10-10μg/ml and 4.209x10-13μg/ml, respectively, justifying the presence of high concentration of flavonoids. In addition, the analgesic studies of M. nudiflora and T. Pallida revealed significant inhibition of writhing upon induction of pain by acetic acid (p<0.001, p<0.05, respectively). The chloroform extract of P.nigrum showed 61.27% inhibition of hypotonic solution induced and 96.61% inhibition of heat induced haemolysis, while the methanolic extract of the plant produced 30.74% of clot lysis confirming a moderate thrombolytic activity. Thus, the present study strives to provide a scientific basis of the traditional uses of the medicinal plants.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"79 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91141389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-27DOI: 10.21065/1920-4159.1000225
S. El-Adl, M. El-Sadek, Hasan Mh
A novel isocratic HPLC method had been developed for rapid simultaneous separation and determination of cinnarizine and Piracetam in pure form or in pharmaceutical formulations within less than 10 minutes. Separation was carried out on a Hypersil gold C18 (10μm, 100x4.6mm) column. Effect of pH and composition of mobile phase in addition to flow rate was studied. Calibration was obeyed in the range of (10-80) μg/ml for cinnarizine or (160- 960) μg/ ml for Piracetam. The method was applied for the simultaneous determination of these drugs in both bulk and pharmaceutical forms and this is the first published method that uses isocratic HPLC method for cinnarizine and piracetam determination in combined formulation and the method were validated according to ICH parameters.
{"title":"Exploring Novel Isocractic HPLC Method for Quantitative Determination of Cinnarizine and Piracetam in Their Capsule Preparations","authors":"S. El-Adl, M. El-Sadek, Hasan Mh","doi":"10.21065/1920-4159.1000225","DOIUrl":"https://doi.org/10.21065/1920-4159.1000225","url":null,"abstract":"A novel isocratic HPLC method had been developed for rapid simultaneous separation and determination of cinnarizine and Piracetam in pure form or in pharmaceutical formulations within less than 10 minutes. Separation was carried out on a Hypersil gold C18 (10μm, 100x4.6mm) column. Effect of pH and composition of mobile phase in addition to flow rate was studied. Calibration was obeyed in the range of (10-80) μg/ml for cinnarizine or (160- 960) μg/ ml for Piracetam. The method was applied for the simultaneous determination of these drugs in both bulk and pharmaceutical forms and this is the first published method that uses isocratic HPLC method for cinnarizine and piracetam determination in combined formulation and the method were validated according to ICH parameters.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"45 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77379952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-22DOI: 10.21065/1920-4159.1000224
Sauda Binte Sunjida, S. Yesmine, Imon Rahman, R. Islam
Rapid industrialization, deteriorating the quality of water leads towards disastrous health effects among the inhabitants of the areas with numerous industries. This study is a brief reflection of the toxicological effects of industrialization on water resources, as well as the pharmacological effects of contaminated household and drinking water on animal model of an industrialized area in a developing country. The obtained results of this study showed high concentration of some heavy metals in the water used in industrial area, than the maximum permissible limit that can be present in water according to the WHO guidelines of water which might cause anomaly in blood composition, severe effect on vital organs such as kidneys and livers. Successively, significant abnormalities were observed in the organs of the tested rat models drinking the water. Therefore, the findings of this study can be used to implement the long term study by broadening the sampling areas and to further elucidate the molecular mechanisms and public health impact associated with human exposure to water contaminated in the industrial areas.
{"title":"Assessing the Quality of Household and Drinking Water in Tongi Industrial Zone of Bangladesh and Its Toxicological Impact on Healthy Sprague Dawley Rats","authors":"Sauda Binte Sunjida, S. Yesmine, Imon Rahman, R. Islam","doi":"10.21065/1920-4159.1000224","DOIUrl":"https://doi.org/10.21065/1920-4159.1000224","url":null,"abstract":"Rapid industrialization, deteriorating the quality of water leads towards disastrous health effects among the inhabitants of the areas with numerous industries. This study is a brief reflection of the toxicological effects of industrialization on water resources, as well as the pharmacological effects of contaminated household and drinking water on animal model of an industrialized area in a developing country. The obtained results of this study showed high concentration of some heavy metals in the water used in industrial area, than the maximum permissible limit that can be present in water according to the WHO guidelines of water which might cause anomaly in blood composition, severe effect on vital organs such as kidneys and livers. Successively, significant abnormalities were observed in the organs of the tested rat models drinking the water. Therefore, the findings of this study can be used to implement the long term study by broadening the sampling areas and to further elucidate the molecular mechanisms and public health impact associated with human exposure to water contaminated in the industrial areas.","PeriodicalId":15238,"journal":{"name":"Journal of Applied Pharmacy","volume":"5 5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80817748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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