K. Mala, A. Logeshwaran, S. Kathiravan, V. Umabarathi, P. Ravikumar
Background: Diabetes mellitus (DM) is a metabolic condition defined by persistent hyperglycemia caused by either insufficient insulin production by the pancreas or inability of peripheral target tissues to respond to normal insulin concentrations. The present study was designed to find the bioactive compounds from the Indian medicinal plants for the treatment of Diabetes mellitus using Virtual screening, Docking and ADMET studies. The 3D structure of phytocompounds was obtained using IMPPAT and PubChem database. The Lipinski rule of five for all the phytocompounds was tested using SwissADME. The sequence of the target protein was retrieved from the UniProt database and modelled using Swiss-Model. The docking studies were performed using PyRx and the results were analyzed using Discovery Studio 2021. Results: The phytocompounds Taraxerol, Obtusifoliol and Kulactone showed very good binding affinity like -9.7, -9.7 and -9.4 Kcal/mol, respectively. Toxicity studies were done for the best-interacted phytocompounds and the results showed that the compounds had very less toxicity. Conclusion: The present study concludes that Taraxerol from Coccinia grandis, Obtusifoliol and Kulactone from Azadirachta indica and may have a potential ability in the treatment of Diabetes Mellitus.
背景:糖尿病(DM)是一种代谢疾病，由胰腺胰岛素分泌不足或周围靶组织不能对正常胰岛素浓度作出反应引起的持续高血糖。本研究旨在通过虚拟筛选、对接和ADMET研究，从印度药用植物中寻找治疗糖尿病的生物活性化合物。利用IMPPAT和PubChem数据库获得植物化合物的三维结构。使用SwissADME测试了所有植物化合物的利平斯基五法则。目标蛋白序列从UniProt数据库中检索，并使用Swiss-Model建模。对接研究使用PyRx进行，结果使用Discovery Studio 2021进行分析。结果:化合物Taraxerol、Obtusifoliol和Kulactone分别表现出-9.7、-9.7和-9.4 Kcal/mol的良好结合亲和力。对相互作用最好的植物化合物进行了毒性研究，结果表明这些化合物的毒性非常小。结论:大球虫中的Taraxerol、印楝中的Obtusifoliol和Kulactone可能具有治疗糖尿病的潜在作用。
{"title":"Virtual screening, Docking and ADMET analysis of bioactive compounds from the Indian medicinal plants for the treatment of Diabetes Mellitus","authors":"K. Mala, A. Logeshwaran, S. Kathiravan, V. Umabarathi, P. Ravikumar","doi":"10.31254/jahm.2023.9207","DOIUrl":"https://doi.org/10.31254/jahm.2023.9207","url":null,"abstract":"Background: Diabetes mellitus (DM) is a metabolic condition defined by persistent hyperglycemia caused by either insufficient insulin production by the pancreas or inability of peripheral target tissues to respond to normal insulin concentrations. The present study was designed to find the bioactive compounds from the Indian medicinal plants for the treatment of Diabetes mellitus using Virtual screening, Docking and ADMET studies. The 3D structure of phytocompounds was obtained using IMPPAT and PubChem database. The Lipinski rule of five for all the phytocompounds was tested using SwissADME. The sequence of the target protein was retrieved from the UniProt database and modelled using Swiss-Model. The docking studies were performed using PyRx and the results were analyzed using Discovery Studio 2021. Results: The phytocompounds Taraxerol, Obtusifoliol and Kulactone showed very good binding affinity like -9.7, -9.7 and -9.4 Kcal/mol, respectively. Toxicity studies were done for the best-interacted phytocompounds and the results showed that the compounds had very less toxicity. Conclusion: The present study concludes that Taraxerol from Coccinia grandis, Obtusifoliol and Kulactone from Azadirachta indica and may have a potential ability in the treatment of Diabetes Mellitus.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85484312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. P Ravikumar Head, P. Srivedha, V. Umabarathi, B. Muhilan, P. Ravikumar
Colorectal cancer is one of the most frequent malignancies worldwide. An uncontrolled growth of the body’s cells can lead to cancer. Cancer of the large intestine (colon) is one of the main causes of death due to cancer. The present study was designed to find the potential phytocompounds from Indian medicinal plants against Colorectal cancer (CRC) using in silico studies. The 3D structure of the target protein was retrieved from the PDB database. The 3D structure of phytocompounds was obtained using IMPPAT, PubChem and Dr. Duke’s database. The Lipinski rule of five for all the phytocompounds was tested using SwissADME. The docking studies were performed using PyRx, and the results were analyzed using Discovery Studio 2021. From the results, the phytocompounds Pamoic acid, Fernenol, and Diosgenin showed very good binding affinity like -9.7, -9.4, and -9.1 Kcal/mol, respectively. Toxicity studies were done for the best-interacted phytocompounds, and the results showed that the compounds had very less toxicity. The present study concludes that Pamoic acid from Catharanthus roseus, Fernenol from Artemisia vulgaris, and Diosgenin from Solanum nigrum has the potential ability to act as a drug for treating colorectal cancer (CRC).
结直肠癌是世界上最常见的恶性肿瘤之一。身体细胞不受控制的生长会导致癌症。大肠癌是癌症导致死亡的主要原因之一。本研究旨在从印度药用植物中寻找抗结直肠癌(CRC)的潜在植物化合物。从PDB数据库中检索目标蛋白的三维结构。植物化合物的三维结构是通过IMPPAT、PubChem和Duke博士的数据库获得的。使用SwissADME测试了所有植物化合物的利平斯基五法则。对接研究使用PyRx进行，结果使用Discovery Studio 2021进行分析。结果表明，Pamoic acid、Fernenol和dioosgenin的结合亲和力分别为-9.7、-9.4和-9.1 Kcal/mol。对相互作用最好的植物化合物进行了毒性研究，结果表明这些化合物的毒性非常小。本研究认为，花楸花中的Pamoic酸、黄蒿中的fenenol和龙葵中的薯蓣皂苷元具有潜在的治疗结直肠癌的药物作用。
{"title":"Finding Focal Adhesion Kinase Inhibitors from Indian Medicinal Plants for Colorectal Cancer- An In-silico Approach","authors":"Dr. P Ravikumar Head, P. Srivedha, V. Umabarathi, B. Muhilan, P. Ravikumar","doi":"10.31254/jahm.2023.9205","DOIUrl":"https://doi.org/10.31254/jahm.2023.9205","url":null,"abstract":"Colorectal cancer is one of the most frequent malignancies worldwide. An uncontrolled growth of the body’s cells can lead to cancer. Cancer of the large intestine (colon) is one of the main causes of death due to cancer. The present study was designed to find the potential phytocompounds from Indian medicinal plants against Colorectal cancer (CRC) using in silico studies. The 3D structure of the target protein was retrieved from the PDB database. The 3D structure of phytocompounds was obtained using IMPPAT, PubChem and Dr. Duke’s database. The Lipinski rule of five for all the phytocompounds was tested using SwissADME. The docking studies were performed using PyRx, and the results were analyzed using Discovery Studio 2021. From the results, the phytocompounds Pamoic acid, Fernenol, and Diosgenin showed very good binding affinity like -9.7, -9.4, and -9.1 Kcal/mol, respectively. Toxicity studies were done for the best-interacted phytocompounds, and the results showed that the compounds had very less toxicity. The present study concludes that Pamoic acid from Catharanthus roseus, Fernenol from Artemisia vulgaris, and Diosgenin from Solanum nigrum has the potential ability to act as a drug for treating colorectal cancer (CRC).","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85775468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction- Ayurveda is the system of medicine for the concept of diseases and health. It is based on concept of Dosha, Dhatu and Mala.As we are following of western life style and food habits blindly, the equilibrium state of Doshas is rapidly disturbing and thus results in shortening of average life expectancy and also now prone towards the Khalitya (hair fall) in early age. Aim & Objectives- Aim- To assess risk factors associated with the Khalitya (Hair fall) in relation to different Deha Prakriti. Objectives- To define level of Khalitya (hair fall) in different Deha Prakriti with the use of hair pull test. To assess the effect of aharaj and viharaj factors in causing Khalitya. Material and Methods- Study design – It is an observational case control study. Male adults of age group between 20 to 50 years were selected. Convenient sampling was used. Cases (50) and controls (50) were selected in 1: 1 proportion. Results and Discussion- Age factor play an important role in Khalitya (p = 0.0365); as age increases the possibility of hair fall also increases. It is well known that, as the level of stress and anger increases, the propensity to develop Vata and Pitta also increases and thereby causes to hair fall. Conclusions- Age is the significant risk factor in causing Khalitya (hair fall); as age increases, there is increased tendency to have hair fall and thus in long run, this will contribute to increased proportion of male pattern baldness among adults.
{"title":"Risk Factors Affecting Khalitya (Hair Fall) As Per Deha Prakruti- A Case Control Study Among Adults","authors":"A. Shete, Pawar Ujwala, MP Nakel","doi":"10.31254/jahm.2023.9204","DOIUrl":"https://doi.org/10.31254/jahm.2023.9204","url":null,"abstract":"Introduction- Ayurveda is the system of medicine for the concept of diseases and health. It is based on concept of Dosha, Dhatu and Mala.As we are following of western life style and food habits blindly, the equilibrium state of Doshas is rapidly disturbing and thus results in shortening of average life expectancy and also now prone towards the Khalitya (hair fall) in early age. Aim & Objectives- Aim- To assess risk factors associated with the Khalitya (Hair fall) in relation to different Deha Prakriti. Objectives- To define level of Khalitya (hair fall) in different Deha Prakriti with the use of hair pull test. To assess the effect of aharaj and viharaj factors in causing Khalitya. Material and Methods- Study design – It is an observational case control study. Male adults of age group between 20 to 50 years were selected. Convenient sampling was used. Cases (50) and controls (50) were selected in 1: 1 proportion. Results and Discussion- Age factor play an important role in Khalitya (p = 0.0365); as age increases the possibility of hair fall also increases. It is well known that, as the level of stress and anger increases, the propensity to develop Vata and Pitta also increases and thereby causes to hair fall. Conclusions- Age is the significant risk factor in causing Khalitya (hair fall); as age increases, there is increased tendency to have hair fall and thus in long run, this will contribute to increased proportion of male pattern baldness among adults.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82594422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is the most common malignancy among women globally and in India. The higher prevalence of advanced breast cancer (ABC) in elderly women is attributable to delayed diagnosis, lack of sufficient health care resources and high costs for conventional treatment). Also, the modern treatment very extensive for ABC cases with surgery, chemotherapy and radiotherapy with little compliance for elderly patients and mortality is mostly linked to the side-effects of these advanced treatments. We report a case of advanced breast cancer (locally advanced to axillary nodes and skeletal muscles) in 76 year-old-female patient who presented with initially with in right subscapular region and insomnia after conventional chemotherapy. She opted for complete Ayurvedic treatment over 8 months which led to complete regression of cancer and local sites. The aim of the case report is present the symptoms, treatment regimens, and dietary modifications of such a case with basic literature review on Ayurveda treatment of breast cancers.
{"title":"Ayurveda treatment strategy in management of advanced breast cancer in elderly female- A case report with review of literature","authors":"V. Lakshmi","doi":"10.31254/jahm.2023.9201","DOIUrl":"https://doi.org/10.31254/jahm.2023.9201","url":null,"abstract":"Breast cancer is the most common malignancy among women globally and in India. The higher prevalence of advanced breast cancer (ABC) in elderly women is attributable to delayed diagnosis, lack of sufficient health care resources and high costs for conventional treatment). Also, the modern treatment very extensive for ABC cases with surgery, chemotherapy and radiotherapy with little compliance for elderly patients and mortality is mostly linked to the side-effects of these advanced treatments. We report a case of advanced breast cancer (locally advanced to axillary nodes and skeletal muscles) in 76 year-old-female patient who presented with initially with in right subscapular region and insomnia after conventional chemotherapy. She opted for complete Ayurvedic treatment over 8 months which led to complete regression of cancer and local sites. The aim of the case report is present the symptoms, treatment regimens, and dietary modifications of such a case with basic literature review on Ayurveda treatment of breast cancers.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79497083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leptadenia pyrotechnica (Forssk.) Decne. (LP) and Capparis cartilaginea Decne. (CC) are plants used in local folk medicine, although there are no published studies on their physiological, hematological, and immune system effects. This study is the first to determine and compare the effects of aqueous LP and CC extracts on body weight parameters, consumptions of feed and water, and the differential complete blood counts in blood samples of healthy Wister albino rats. Six groups of rats (3 rats/group) were orally gavage separately with the aqueous extracts of LP (groups LP1, LP2, and LP3, respectively) and CC (groups CC1, CC2, and CC3, respectively) at concentrations of 30, 100, and 200 mg/kg body weight, while three control rats were gavage with water, daily for two weeks. Body weights were measured daily. The mean total body weights were not significantly different between all groups, between the experimental groups and the control group, and between the equal concentrations of LP and CC groups. The mean total and daily body weight gains and percent relative total body weight gain for the LP3 group were significantly lower compared with the control group. The mean feed and water intakes were highly significantly lower for the LP2, LP3, CC2, and CC3 groups compared with the control group, and for the LP3 group it was significantly lower compared with the CC3 group. The FER for the LP3 group was significantly lower compared with the control group. The mean lymphocyte percent for CC1 was significantly higher and the mean lymphocyte count for LP1 was significantly lower compared with the control. The mean neutrophil percent for LP1 was significantly higher than for CC1 and the mean lymphocyte percents for LP1 and LP2 were significantly lower than for CC1 and CC2. In conclusion, the LP extract enhances the innate immune response and inhibits the acquired immune response, while the CC extract does the exact opposite. Thus, the extract may be used for modulating the immune response.
{"title":"The aqueous extract of Leptadenia Pyrotechnica Decne enhances the innate immune response and inhibits the acquired immune response, while the aqueous extract of Capparis Cartilaginea Decne does the exact opposite in Healthy Rats","authors":"Elham H Algahdali, S. Mahassni","doi":"10.31254/jahm.2023.9206","DOIUrl":"https://doi.org/10.31254/jahm.2023.9206","url":null,"abstract":"Leptadenia pyrotechnica (Forssk.) Decne. (LP) and Capparis cartilaginea Decne. (CC) are plants used in local folk medicine, although there are no published studies on their physiological, hematological, and immune system effects. This study is the first to determine and compare the effects of aqueous LP and CC extracts on body weight parameters, consumptions of feed and water, and the differential complete blood counts in blood samples of healthy Wister albino rats. Six groups of rats (3 rats/group) were orally gavage separately with the aqueous extracts of LP (groups LP1, LP2, and LP3, respectively) and CC (groups CC1, CC2, and CC3, respectively) at concentrations of 30, 100, and 200 mg/kg body weight, while three control rats were gavage with water, daily for two weeks. Body weights were measured daily. The mean total body weights were not significantly different between all groups, between the experimental groups and the control group, and between the equal concentrations of LP and CC groups. The mean total and daily body weight gains and percent relative total body weight gain for the LP3 group were significantly lower compared with the control group. The mean feed and water intakes were highly significantly lower for the LP2, LP3, CC2, and CC3 groups compared with the control group, and for the LP3 group it was significantly lower compared with the CC3 group. The FER for the LP3 group was significantly lower compared with the control group. The mean lymphocyte percent for CC1 was significantly higher and the mean lymphocyte count for LP1 was significantly lower compared with the control. The mean neutrophil percent for LP1 was significantly higher than for CC1 and the mean lymphocyte percents for LP1 and LP2 were significantly lower than for CC1 and CC2. In conclusion, the LP extract enhances the innate immune response and inhibits the acquired immune response, while the CC extract does the exact opposite. Thus, the extract may be used for modulating the immune response.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84450382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pumpkin, belongs to the family Cucurbitaceae and genus Cucurbita, is gaining appeal across the world for a number of reasons. Pumpkin seeds have always been discarded as waste even with containing essential pharmaceutical micro and macro constituents such as proteins, antioxidative phenolic compounds, tocopherols, triterpenes, saponins, phytosterols, lignans, and carotenoids as well as these compounds D-chiro-inositol, trigonelline, and nicotinic acid. Pumpkin seeds are also rich in fibre, polyunsaturated fatty acids, vitamins, and minerals including zinc, iron, magnesium, calcium, manganese, and copper that may be used in the food industry. Pumpkin seeds are now generally used in traditional medicine in treatment of many diseases, including hypertension, rheumatoid arthritis, hyperglycemia, inflammation, dyslipidemia, bacteria, fungal infections, and tumours. As a result, pumpkin seeds are now often utilised as a herbal treatment or health-improving agent for both people and animals, and food scientists are providing the pumpkin-infused products to the food and health industries. Hence, food manufacturers have worked to broaden the range of appetiser, baking, and snack uses for pumpkin seeds. This review article provides insights into the pharmacological activities of pumpkin seeds and the possible processes which, might reduce the chance of a wide range of problems.
{"title":"Potential Pharmacological Activities of Pumpkin Seeds as a Functional Food: A Comprehensive Review","authors":"Manshi, Neelam Chaturvedi","doi":"10.31254/jahm.2023.9209","DOIUrl":"https://doi.org/10.31254/jahm.2023.9209","url":null,"abstract":"Pumpkin, belongs to the family Cucurbitaceae and genus Cucurbita, is gaining appeal across the world for a number of reasons. Pumpkin seeds have always been discarded as waste even with containing essential pharmaceutical micro and macro constituents such as proteins, antioxidative phenolic compounds, tocopherols, triterpenes, saponins, phytosterols, lignans, and carotenoids as well as these compounds D-chiro-inositol, trigonelline, and nicotinic acid. Pumpkin seeds are also rich in fibre, polyunsaturated fatty acids, vitamins, and minerals including zinc, iron, magnesium, calcium, manganese, and copper that may be used in the food industry. Pumpkin seeds are now generally used in traditional medicine in treatment of many diseases, including hypertension, rheumatoid arthritis, hyperglycemia, inflammation, dyslipidemia, bacteria, fungal infections, and tumours. As a result, pumpkin seeds are now often utilised as a herbal treatment or health-improving agent for both people and animals, and food scientists are providing the pumpkin-infused products to the food and health industries. Hence, food manufacturers have worked to broaden the range of appetiser, baking, and snack uses for pumpkin seeds. This review article provides insights into the pharmacological activities of pumpkin seeds and the possible processes which, might reduce the chance of a wide range of problems.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79590753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Polycystic Ovarian Syndrome is one of the most common metabolic and reproductive disorder among women of reproductive age. This condition is characterized by elevated androgen levels, anovulatory menstrual abnormalities and multiple small cysts in ovaries. This female endocrine disorder is prevalent in age group of 18-45 years with rate ranging from 2.2% to 26%. Sedentary life style, faulty dietary habits lead to obesity in young adults which results in metabolic and hormonal disturbances such as insulin resistance, hyperandrogenemia etc. In Ayurvedic literature, the features associated with PCOS closely resemble with Nasta Artava, Ksheen Artava and a group of Yoni Vyapada like Bandhya, Arajska, Lohitkshara and Artava Vaha Strotas Viddh Lakshana mentioned by Acharya Sushruta. PCOS also has close resemblance with Pushpghani Jatharini mentioned by Acharya Kashyapa. Symptoms of PCOS mimic with conditions like Sthoulya, Aratava Kshaya, Agni Mandya, Rrakta/Medo Dhatu Dushti, Granthi Roga. So, based upon Rog lakshana and dosha dushya involvement, Ayurveda explains Nidana parivarjanam and Shamshodhan as a prime line of treatment for PCOS. Aim & Objectives: The main aim of this study is to establish the role of Samshodhan therapy in PCOS. PCOS can be considered as Tridoshaj Vyadhi with Vata & Kapha predominance that is the reason Vamana for Kapha Shodhan and Virechana for Vata and Pitta Sanshuddhi were planned to achieve desired results. Results: In this case study, a 27 years female patient suffering from symptoms like Ksheen Artava, Granthibhoot artava, Sthoulya, was managed with Samshodhan therapy and got complete relief from symptoms. Conclusion: This case study corroborates the importance of Samshodhan Chikitsa in PCOS.
{"title":"Managing PCOS with Samshodhan Therapy: A Case Report","authors":"Chanderlata Suman, S. Kapil, Anil Bhardwaj","doi":"10.31254/jahm.2023.9202","DOIUrl":"https://doi.org/10.31254/jahm.2023.9202","url":null,"abstract":"Background: Polycystic Ovarian Syndrome is one of the most common metabolic and reproductive disorder among women of reproductive age. This condition is characterized by elevated androgen levels, anovulatory menstrual abnormalities and multiple small cysts in ovaries. This female endocrine disorder is prevalent in age group of 18-45 years with rate ranging from 2.2% to 26%. Sedentary life style, faulty dietary habits lead to obesity in young adults which results in metabolic and hormonal disturbances such as insulin resistance, hyperandrogenemia etc. In Ayurvedic literature, the features associated with PCOS closely resemble with Nasta Artava, Ksheen Artava and a group of Yoni Vyapada like Bandhya, Arajska, Lohitkshara and Artava Vaha Strotas Viddh Lakshana mentioned by Acharya Sushruta. PCOS also has close resemblance with Pushpghani Jatharini mentioned by Acharya Kashyapa. Symptoms of PCOS mimic with conditions like Sthoulya, Aratava Kshaya, Agni Mandya, Rrakta/Medo Dhatu Dushti, Granthi Roga. So, based upon Rog lakshana and dosha dushya involvement, Ayurveda explains Nidana parivarjanam and Shamshodhan as a prime line of treatment for PCOS. Aim & Objectives: The main aim of this study is to establish the role of Samshodhan therapy in PCOS. PCOS can be considered as Tridoshaj Vyadhi with Vata & Kapha predominance that is the reason Vamana for Kapha Shodhan and Virechana for Vata and Pitta Sanshuddhi were planned to achieve desired results. Results: In this case study, a 27 years female patient suffering from symptoms like Ksheen Artava, Granthibhoot artava, Sthoulya, was managed with Samshodhan therapy and got complete relief from symptoms. Conclusion: This case study corroborates the importance of Samshodhan Chikitsa in PCOS.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90342422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Menopause is usually associated with inevitable manifestation of ageing process in women. In Ayurveda Rajonivrutti is described as end of Artava Pravrutti. This is associated with distressing physical, pshycological, vasomotor and sexual symptoms that degrades the quality of life- and life-threatening health risks. Aims and objectives: Aim was to create awareness regarding predisposing factors, preventive and treatment measures among menopausal women. Objective was to find out the prevalence, severity of menopausal symptoms and quality of life, to assess the role of sociodemographic characteristics, predisposing factors influencing occurrence of Menopause and complications of menopause, to assess the association between Prakriti of patients and Menopausal Symptoms. Materials and Methods: A cross sectional survey study was conducted in the 206 patients of the age group 45-65 years through face-to-face interview method by using survey questionnaire, which consists of three parts. 1) assessement of sociodemographic data, 2) Prakruti assessment questionnaire, 3) evaluation of symptoms using a standard validated Menopause specific QOL (MENQOL) Questionnaire. Results: Maximum no. of patients participated in the survey 40-45 yrs (67%); married (96.1%); uneducated (47.6 %); (63.6 %) Vishamagni; (60.7% ) disturbed sleep; ( 44.7%) excessive use of Madhura Rasa (85.4%) Katu Rasa (16.5 %), Amla Rasa ( 9.2%) Lavana Rasa (8.7%), Vishamashana (87.4%) ; (48.5%) Avyayama; Vata Pitta Prakriti (76.7%) ; The mean score of vasomotor symptoms, psychosocial symptoms, sexual symptoms and physical symptoms is (6.89 ± 0.83), (6.53 ± 1.12), (5.91 ± 2.94), (5.60 ± 1.00) respectively. Conclusion: The sociodemographic factors such as age, marital status, education, socioeconomic status, contraception and etiological factors such as Vishamasana, excessive use of Madhura Rasa, Katu Rasa, Amla Rasa, LavanaRasa, Avyayama can influence the severity of menopausal symptoms. Vatapitta Prakruti patients are more prone to menopausal symptoms. The quality of life of Menopausal women in this survey study are more troublesome by vasomotor symptoms followed by psychosocial, physical and sexual symptoms respectively.
{"title":"A Crosssectional survey research to assess the determinants of Menopause, prevalence and severity of menopausal symptoms and its impact on quality of life of menopausal women","authors":"M. Akhila, L. Dei","doi":"10.31254/jahm.2023.9101","DOIUrl":"https://doi.org/10.31254/jahm.2023.9101","url":null,"abstract":"Background: Menopause is usually associated with inevitable manifestation of ageing process in women. In Ayurveda Rajonivrutti is described as end of Artava Pravrutti. This is associated with distressing physical, pshycological, vasomotor and sexual symptoms that degrades the quality of life- and life-threatening health risks. Aims and objectives: Aim was to create awareness regarding predisposing factors, preventive and treatment measures among menopausal women. Objective was to find out the prevalence, severity of menopausal symptoms and quality of life, to assess the role of sociodemographic characteristics, predisposing factors influencing occurrence of Menopause and complications of menopause, to assess the association between Prakriti of patients and Menopausal Symptoms. Materials and Methods: A cross sectional survey study was conducted in the 206 patients of the age group 45-65 years through face-to-face interview method by using survey questionnaire, which consists of three parts. 1) assessement of sociodemographic data, 2) Prakruti assessment questionnaire, 3) evaluation of symptoms using a standard validated Menopause specific QOL (MENQOL) Questionnaire. Results: Maximum no. of patients participated in the survey 40-45 yrs (67%); married (96.1%); uneducated (47.6 %); (63.6 %) Vishamagni; (60.7% ) disturbed sleep; ( 44.7%) excessive use of Madhura Rasa (85.4%) Katu Rasa (16.5 %), Amla Rasa ( 9.2%) Lavana Rasa (8.7%), Vishamashana (87.4%) ; (48.5%) Avyayama; Vata Pitta Prakriti (76.7%) ; The mean score of vasomotor symptoms, psychosocial symptoms, sexual symptoms and physical symptoms is (6.89 ± 0.83), (6.53 ± 1.12), (5.91 ± 2.94), (5.60 ± 1.00) respectively. Conclusion: The sociodemographic factors such as age, marital status, education, socioeconomic status, contraception and etiological factors such as Vishamasana, excessive use of Madhura Rasa, Katu Rasa, Amla Rasa, LavanaRasa, Avyayama can influence the severity of menopausal symptoms. Vatapitta Prakruti patients are more prone to menopausal symptoms. The quality of life of Menopausal women in this survey study are more troublesome by vasomotor symptoms followed by psychosocial, physical and sexual symptoms respectively.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84971698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paba Senarath, V. Paheerathan, S. Ramiah, Piratheepkumar Rajadurai
The purpose of this study was to determine the larvicidal effect of aqueous extracts of different parts of the Plumbago zeylanica plant on the dengue vector, Aedes aegypti. This research assessed P. zeylanica for its larvicide activity against A. aegypti larvae. Five different concentrations of hot and cold aqueous extracts of root, leaf, and stem powders of P. zeylanica were separately prepared. The larvicidal effect of these extracts was assessed against early 1st, 3rd, and 4th instar larvae of Aedes aegypti. Mosquito larvae were sampled, larval populations were monitored before and after application of aqueous extracts, and larval mortality was monitored after 12, 24, and 48 hours. Three trials were carried out under the same conditions. The percentage mortality of larvae in the sample was calculated, and the mean mortality was obtained for the 3 trials. Then the LC50 value was calculated according to the mean mortality with the SPSS package. The lowest LC50 values were obtained for the hot aqueous extracts on 1st instar larvae: root 122.74 mg/l, leaf 274.95 mg/l and stem 275.92 mg/l, 3rd instar larvae: root 129.37 mg/l, leaf 205.74 mg/l and stem 286.21 mg/l, 4th instar larvae: root 165.52 mg/l, leaf 216.89 mg/l and stem 329.94 mg/l and the root was found to have the highest larvicide activity. Finally, it was identified that by using 165.52 mg/l all three larval instar stages could be killed up to 50% and 90% with 280.921 mg/l. The present study reports that Plumbago zeylanica could serve as a potential larvicidal agent.
{"title":"Evaluation of Larvicidal Activity of Aqueous Extracts of Leaves, Root, Stem of Plumbago zeylanica Plant on Aedes aegypti","authors":"Paba Senarath, V. Paheerathan, S. Ramiah, Piratheepkumar Rajadurai","doi":"10.31254/jahm.2023.9102","DOIUrl":"https://doi.org/10.31254/jahm.2023.9102","url":null,"abstract":"The purpose of this study was to determine the larvicidal effect of aqueous extracts of different parts of the Plumbago zeylanica plant on the dengue vector, Aedes aegypti. This research assessed P. zeylanica for its larvicide activity against A. aegypti larvae. Five different concentrations of hot and cold aqueous extracts of root, leaf, and stem powders of P. zeylanica were separately prepared. The larvicidal effect of these extracts was assessed against early 1st, 3rd, and 4th instar larvae of Aedes aegypti. Mosquito larvae were sampled, larval populations were monitored before and after application of aqueous extracts, and larval mortality was monitored after 12, 24, and 48 hours. Three trials were carried out under the same conditions. The percentage mortality of larvae in the sample was calculated, and the mean mortality was obtained for the 3 trials. Then the LC50 value was calculated according to the mean mortality with the SPSS package. The lowest LC50 values were obtained for the hot aqueous extracts on 1st instar larvae: root 122.74 mg/l, leaf 274.95 mg/l and stem 275.92 mg/l, 3rd instar larvae: root 129.37 mg/l, leaf 205.74 mg/l and stem 286.21 mg/l, 4th instar larvae: root 165.52 mg/l, leaf 216.89 mg/l and stem 329.94 mg/l and the root was found to have the highest larvicide activity. Finally, it was identified that by using 165.52 mg/l all three larval instar stages could be killed up to 50% and 90% with 280.921 mg/l. The present study reports that Plumbago zeylanica could serve as a potential larvicidal agent.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85390799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated in vitro antioxidant and acute anti-inflammatory effect of aerial parts of Morinda umbellata L. (ML). Extracts of ethanol 70% were used to evaluate pharmacological activities. Total flavonoid content (TFC), and the scavenging effect on DPPH radical were exhibited. The effect on acute anti-inflammation was evaluated by in vivo models. It was found that the TFC, antioxidant ability and acute anti-inflammatory effect of the ML leave extract was higher and more effective than this of the stem extract.
{"title":"Antioxidant and acute antiinflammatory activities of aerial parts of Morinda umbellata L","authors":"Quang-Ung Le, Thi-Ngoc Lanh, The-Huan Nguyen","doi":"10.31254/jahm.2023.9104","DOIUrl":"https://doi.org/10.31254/jahm.2023.9104","url":null,"abstract":"This study investigated in vitro antioxidant and acute anti-inflammatory effect of aerial parts of Morinda umbellata L. (ML). Extracts of ethanol 70% were used to evaluate pharmacological activities. Total flavonoid content (TFC), and the scavenging effect on DPPH radical were exhibited. The effect on acute anti-inflammation was evaluated by in vivo models. It was found that the TFC, antioxidant ability and acute anti-inflammatory effect of the ML leave extract was higher and more effective than this of the stem extract.","PeriodicalId":15252,"journal":{"name":"Journal of Ayurvedic and Herbal Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74662650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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