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Biochemical Characterisation and in vitro anti-cancerous potential of Karpa Chenthur, an herbal formulation prepared from selective Indian Medicinal Plants Karpa Chenthur的生物化学特性和体外抗癌潜力,这是一种由精选的印度药用植物制备的草药配方
Pub Date : 2022-09-30 DOI: 10.31254/jahm.2022.8309
RK Arravinth Kumar, Bar Karuppana Ssami
Phytochemical compounds have been the starting point for the innovation of many modern drugs. In the present study, the anticancer properties of Karpa Chenthur, an herbal formulation prepared from four selected medicinal plants of India by virtue of their claimed anticancer properties in Indian traditional medicinal system. The in vitro studies conducted in different cancer cell lines confirmed the anti-cancer property of the herbal formulation. The anticancer property is probably due to the presence of flavonoids in the sample. Phytochemical analysis and assays also confirmed the presence of rich flavonoid contents followed by polyphenolics and glycosides. The preliminary results of the present study has indicated that the administration of Karpa Chenthur can ameliorate the adverse effects associated with cancer.
植物化学化合物一直是许多现代药物创新的起点。在本研究中,Karpa Chenthur的抗癌特性,是一种草药配方,由四种精选的印度药用植物制备而成,凭借其在印度传统医学系统中声称的抗癌特性。在不同的癌细胞系中进行的体外研究证实了该草药配方的抗癌特性。这种抗癌特性可能是由于样品中含有类黄酮。植物化学分析和测定也证实了其含有丰富的类黄酮,其次是多酚类和苷类。本研究的初步结果表明,服用Karpa Chenthur可以改善与癌症相关的不良反应。
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引用次数: 0
A Randomized Controlled Double Blind clinical trial to evaluate the efficacy of Vedanasthapana Mahakashaya as an anxiolytic and analgesic polyherbal drug in perioperative anorectal cases 一项随机对照双盲临床试验评估vedanastasapana Mahakashaya作为一种抗焦虑和镇痛的多草药药物在肛门直肠围手术期的疗效
Pub Date : 2022-09-30 DOI: 10.31254/jahm.2022.8308
Prem Kumar, O. Dave, B. Paliwal
Introduction: In surgery, pre-operatively anxiolytic drugs and analgesics are very essential for major or minor surgical procedures to better operative and post-operative outcomes. The Vedanasthapana mahakashaya, described by the Acharya Charaka, is a group of 10 herbs and those herbs are advocated as analgesic, and anxiolytic polyherbal composition by various text books of ayurveda. So, the aim of this study was to evaluate and compare the efficacy of the Vedanasthapana mahakashaya as an analgesic drug during post operative period and as an anxiolytic drug for pre operative anxiety. Metarials & Methods: The study was a prospective, randomized, double blind, controlled trial. 80 patients of anorectal diseases who undergone for surgical intervention were randomly allocated in one of two groups. Group-1 received Vedanasthapana mahakashaya kwath (Decoction), 30ml orally in preoperative and postoperative period while group-2 was treated with Tab. Alprazolam 0.25mg pre-operatively and Tab. Paracetamol 500 mg postoperatively. Anxiety was assessed on the basis of Anxiety score of Hospital Anxiety and Depression Scale (HADS) preoperatively and analgesia was assessed postoperatively by internationally validated Visual Analogue Scale. Inj. Diclofenac sodium 75mg IM was administered as a rescue analgesic. Results: Pain-baseline pain scores were not statistically differed in both groups. Both the groups showed statistically significant reduction in pain at the end of trial period. Both were found to be significantly similar (P 0.4856) but group-1 showed more reduction in pain 84.72% (P<0.0001) than the group-2 which have 80.08% reduction in VAS score (P<0.0001) Anxiety- The values of both the groups were showing statistically significant difference at different observational intervals but the reduction was significantly higher in group-2 (P<0.0158). Conclusion: Administration of the Vedanasthapana mahakashaya decoction is effective for post operative pain relief but less effective for preoperative anxiety.
前言:在外科手术中,术前抗焦虑药物和镇痛药物对于大大小小的外科手术是非常必要的,以获得更好的手术和术后效果。《阿查里亚·查罗卡》(Acharya Charaka)中描述的吠陀那斯塔帕那(vedanasasapana mahakashaya)是一组由10种草药组成的草药,这些草药被各种阿育吠陀教科书主张为止痛和抗焦虑的多草药成分。因此,本研究的目的是评估和比较vedanasasapana mahakashaya作为术后镇痛药物和术前焦虑抗焦虑药物的疗效。材料与方法:本研究为前瞻性、随机、双盲、对照试验。80例接受手术干预的肛肠疾病患者随机分为两组。组1患者术前、术后口服吠檀散大花散汤30ml,组2患者口服Tab。术前阿普唑仑0.25mg。扑热息痛500毫克术后。术前采用医院焦虑抑郁量表(HADS)焦虑评分进行焦虑评估,术后采用国际认可的视觉模拟量表进行镇痛评估。Inj。双氯芬酸钠75mg IM作为抢救镇痛药。结果:两组疼痛基线评分无统计学差异。两组在试验结束时疼痛均有统计学上的显著减轻。两组差异有统计学意义(P< 0.4856),但组1的疼痛减轻率为84.72% (P<0.0001),组2的VAS评分降低率为80.08% (P<0.0001)。焦虑-两组在不同观察间隔内差异有统计学意义,但组2的减轻率明显高于组2 (P<0.0158)。结论:吠檀散对术后疼痛有明显的缓解作用,但对术前焦虑的缓解效果较差。
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引用次数: 0
Application of Trisootra Principles in the Management of Acute Food Allergy - A Case Report 三索特拉原理在急性食物过敏治疗中的应用- 1例报告
Pub Date : 2022-09-30 DOI: 10.31254/jahm.2022.8303
Mahesh P Savalagimath, A. M, Neha K Pol, Veenashree C Hiremath
Food allergies are thought to affect up to 4% of adults and 8% of children under the age of five. Although there is no treatment, some kids outgrow their food allergies as they age. Foods can be contaminated by a wide range of diseasecausing microbes, leading to a wide range of foodborne illnesses (also known as foodborne sickness or food poisoning) and food allergies. An immune system response called a food allergy happens quickly after consuming a certain meal. Even a small amount of the food that causes the allergy can result in signs and symptoms like skin issues, hives, or enlarged airways. Some people may experience severe symptoms from a food allergy, including the potentially fatal anaphylactic reaction. In Ayurveda , rules for intake of food, preparation and sign and symptoms of visha misritha anna and their treatments are well explained. Proper history taking is an essential method in all these cases. In present case a 19-year male patient with the chief complaints of, severe itching and appearance of rashes over the neck, back ,arms and chest region of the body after ingesting food hence diagnosed as an acute food allergy have shown encouraging results when treated with Trisutra principles.
食物过敏被认为影响了4%的成年人和8%的5岁以下儿童。虽然没有治疗方法,但随着年龄的增长,有些孩子的食物过敏症状会消失。食物可能被各种致病微生物污染,导致各种食源性疾病(也称为食源性疾病或食物中毒)和食物过敏。一种叫做食物过敏的免疫系统反应在吃了一顿饭后很快就会发生。即使是少量引起过敏的食物也会导致皮肤问题、荨麻疹或呼吸道扩张等症状。有些人可能会经历食物过敏的严重症状,包括可能致命的过敏反应。在阿育吠陀,食物的摄入规则,准备和visha misritha anna的体征和症状及其治疗都有很好的解释。在所有这些情况下,适当的历史记录是必不可少的方法。在本病例中,一名19岁的男性患者,在摄入食物后,颈部、背部、手臂和胸部出现严重瘙痒和皮疹,因此被诊断为急性食物过敏,在接受Trisutra原则治疗后显示出令人鼓舞的结果。
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引用次数: 0
Review on preclinical and clinical trials of Indian herbal formulation against SARC COV-2 印度中药制剂抗SARC - COV-2临床前和临床试验综述
Pub Date : 2022-09-30 DOI: 10.31254/jahm.2022.8311
N. Mishra, Shraddha Tripathi, Pragya Mishra, N. Mishra
Mutation of the SARS-CoV-2 spikes protein leads to the appearance of novel variants with modified form that appear to be more transmissible and can escape immunity generated by the vaccine. Continuous mutation in SARC COV and the emergence of more competent variants have sparked alarm for the alternative way to strengthen the immunity and fight corona sustainably. Natural products have been investigated in the last decades to develop novel candidates for drug research. Medicinal plants are considered helpful for preventing and treating several diseases and COVID-19 patients. Thus, this review presents the Indian medicinal plant and its promising active ingredients that exhibit inhibitory activity against SARS-CoV-2. The present paper also reviewed the AYUSH recommended formulations and their ingredients routinely used by the Indian population and covid positive patients.
SARS-CoV-2刺突蛋白的突变导致出现具有修饰形式的新变体,这些变体似乎更具传染性,并且可以逃避疫苗产生的免疫。SARC冠状病毒的持续突变和更强变异的出现引发了人们对增强免疫力和可持续抗击冠状病毒的替代方法的警惕。在过去的几十年里,人们对天然产物进行了研究,以开发新的药物研究候选物。药用植物被认为有助于预防和治疗几种疾病和COVID-19患者。因此,本文综述了印度药用植物及其具有抑制SARS-CoV-2活性的活性成分。本文还回顾了印度人口和covid阳性患者常规使用的AYUSH推荐配方及其成分。
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引用次数: 0
Morpho-Anatomical, Preliminary Phytochemical and Hptlc Profile of Extra-Pharmacopoeial Herb Passiflora foetida Linn. Leaf 外药典药材西番莲的形态解剖、初步植物化学和Hptlc图谱。叶
Pub Date : 2022-09-30 DOI: 10.31254/jahm.2022.8307
Shruthi Pandith, S. Bhat, K. S. Kumar
Background: Medicine has evolved after a lot of trial and error practices. Ayurveda is a life science which is meant for well-being of all living creature. The medicinal importance of wide range of plants has been recorded in Ayurveda, but some plants which are found later or exotic are not mentioned in Ayurveda, they are named as Anukta which means untold. Ethnobotany is the branch of botany which deals with the study of relationship between people and plants. Passiflora foetida Linn. is an extra pharmacopeial drug in Ayurveda, which is used by folklore and traditional healers for various ailments like hysteria, skin disease, asthma, headache, for poisonous bites, digestive complaints etc. Methodology: Pharmacognostic, physico-chemical, preliminary phytochemical study and HPTLC studies were carried out following standard procedures mentioned in Pharmacopoeias. Results: Pharmacognostic study revealed macromicroscopic features of the plant. Physicochemical studies gave information about the moisture content, total ash, acid insoluble ash, water soluble ash, alcohol soluble extractive and water soluble extractive. Preliminary phytochemical evaluation of alcoholic extract revealed the presence of phenols, alkaloids and resins. HPTLC study revealed the fingerprint of extract of the plant sample. Conclusion: The results obtained from the studies will help in the standardisation of the plant material.
背景:医学是经过大量的试验和错误实践而发展起来的。阿育吠陀是一门生命科学,它意味着所有生物的幸福。阿育吠陀记载了多种植物的药用价值,但一些后来发现的或外来的植物在阿育吠陀中没有被提及,它们被命名为Anukta,意思是不为人知的。民族植物学是植物学的一个分支,主要研究人与植物之间的关系。西番莲。是阿育吠陀的一种额外的药典药物,被民间传说和传统治疗师用于治疗各种疾病,如歇斯底里症、皮肤病、哮喘、头痛、中毒咬伤、消化系统疾病等。方法学:按照药典中规定的标准程序进行生药学、理化、植物化学初步研究和HPTLC研究。结果:生药学研究揭示了该植物的显微特征。理化研究给出了水分含量、总灰分、酸不溶灰分、水溶性灰分、醇溶浸出物和水溶性浸出物的信息。酒精提取物的初步植物化学评价显示存在酚类、生物碱和树脂。hplc分析显示了该植物提取物的指纹图谱。结论:本研究的结果将有助于植物原料的标准化。
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引用次数: 0
To Investigate the Possible Mechanism of “Asthisanghar Churna” in Asthi Bhagna W.s.r. To bone fracture: A Review Study 巴格纳哮喘病致骨折可能机制的研究综述
Pub Date : 2022-06-30 DOI: 10.31254/jahm.2022.8213
Sujata Rathore, Bandapalle Dattu Narayanrao
According to modern science Bhagna (bone fracture) is include under of Fracture. Generally, fracture take time to heal in adults 6-8 weeks, and this time of duration patient must go on bed and because of this condition may develop some complications like muscle wasting, joint stiffness, thrombosis in deep veins, improper movement of that joint etc. along these hazards patients suffers other things also like stress, irritation, and prolong healing create financial problems. It is approximate that 80% of the population faith on tradition herbal (ayurvedic) medicine which are living in developing countries. Now this modern world’s big problem and challenge is the managing of the skeletal coordination damages which come about as the consequence of trauma in maximum cases. In ancient period. Acharya Sushruta already mentioned that herbs can sufficiently effective in reducing swelling, pain and soreness of the fracture and also speedy recovery of function. Aim of this paper presents for evaluate a significant viewpoint of healing of bone breakage (bhagna) management according to the Ayurveda practice. Possession above aim in thoughts we selected “asthisanghar churna” from “Chakradutta Bhagna Chikitsa (CBC)” after which applicable keywords have been examined in diverse Ayurveda and cutting-edge writings in addition to on on-line databanks to recognize the mode of action (MOA) of character contents of Rasonadi Kalka in accelerating fractured bone recovery in instances of Bhagna (bone fracture).
根据现代科学,骨折是骨折的一种。一般来说,成人骨折需要6-8周的时间才能愈合,这段时间患者必须卧床休息,因为这种情况可能会产生一些并发症,如肌肉萎缩,关节僵硬,深静脉血栓形成,关节不正确运动等。伴随着这些危险,患者还会遭受其他事情,如压力,刺激,延长愈合时间,造成经济问题。大约80%的人口信仰传统草药(阿育吠陀)药物,这些人生活在发展中国家。当今世界最大的问题和挑战是如何处理创伤导致的骨骼协调损伤。在古代。Acharya Sushruta已经提到,草药可以充分有效地减少骨折的肿胀,疼痛和酸痛,并迅速恢复功能。本文的目的是根据阿育吠陀的实践,对骨折愈合(bhagna)的管理提出一个有意义的观点。拥有上述目标的思想,我们从“Chakradutta Bhagna Chikitsa (CBC)”中选择了“asthisanghar churna”,然后在各种阿育吠陀和前沿著作以及在线数据库中检查了适用的关键词,以识别Rasonadi Kalka字符内容在加速Bhagna(骨折)情况下骨折恢复的作用模式(MOA)。
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引用次数: 0
Concept of jihwa pariksha w.s.r. to mutravaha sroto vikaras jihwa pariksha的概念是由mutraaha sroto vikaras组成的
Pub Date : 2022-06-30 DOI: 10.31254/jahm.2022.8212
Nency Vaghasiya, S. Deva
In the same way that the Doshas as well as Dhatus feed our bodies, the Mala as well as its functions keep the body together. Srotas creates Dhatus and Mala and then transfers them out. Srotas are anatomical structures that convey the Dosha, Dhatu, and Mala energies. There are 13 Antarmukha Srotas, as per Sthanabheda (place of origin), as well as Mutravaha Srotas is among them. Basti but also Medhra, or Basti and vankshana, were Moolasthana of Mutravaha srotas, according to Ayurvedic literature. Varied Acharyas have different perspectives on Moolasthana, indicating where practically all of that Srota's actions take place, as well as which is most afflicted during clinical manifestations. Having function like eliminating the unctuousness out of the body, Mutra helps in removing excessive kleda out of the body which may be generated through vitiation of Kledaka kapha and Bodhaka kapha. Having a seat of Bodhaka kapha, changes on jihwa can be manifested due to ama which ultimately produced by the impairment of functions of Mutra. The study's end goal is to define the principle of Jihwa Pariksha W.S.R. To Mutravaha Sroto Vikaras, as well as explore the significance of Ayurveda, dosha, and dhatus for bodily sustenance. The study's future possibilities are that individuals would understand the important ideas of Ayurveda and srotas by reading this article.
就像Doshas和Dhatus滋养我们的身体一样,Mala和它的功能使身体保持在一起。斯罗塔斯创造了达图斯和玛拉,然后把它们转移出去。脉塔是传递多沙、达图和玛拉能量的解剖结构。根据Sthanabheda(原籍地),有13个Antarmukha Srotas, Mutravaha Srotas也在其中。根据阿育吠陀文献,Basti和Medhra,或者Basti和vankshana都是Mutravaha srotas的Moolasthana。不同的阿查里亚对Moolasthana有不同的看法,表明实际上所有斯罗塔的行为都发生在哪里,以及在临床表现中哪个最受折磨。有功能像消除身体的油腻,佛经有助于消除多余的kleda从身体可能产生的Kledaka kapha和Bodhaka kapha的破坏。有了菩提卡法的座位,在智化上的变化可以表现出来,因为ama最终是由佛法功能的损害而产生的。本研究的最终目标是定义Jihwa Pariksha W.S.R. to Mutravaha Sroto Vikaras的原则,以及探索阿育吠陀,dosha和dhatus对身体营养的意义。这项研究未来的可能性是,通过阅读这篇文章,个人将理解阿育吠陀和斯罗塔的重要思想。
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引用次数: 0
Lactose intolerance: an ayurvedic perspective-a conceptual study 乳糖不耐症:阿育吠陀的观点-一项概念性研究
Pub Date : 2022-06-30 DOI: 10.31254/jahm.2022.8216
Aashik M Raju, Akashdeep A. Meshram
Ayurveda appears to have had a different view of food and its function in maintaining good health and curing diseases, even before the dawn of mainstream clinical research. Ayurveda believes that healthy eating is the basis of success and well-being, whereas unnatural nutrition is the basis of all maladies. In Ayurveda-sector, food is known as rasayana, vibrant, etc. Milk is also regarded as a complete-food by modern medical science. Lactose intolerance is a condition that limits the feeding of milk in humans. After infancy, like further creatures, most humans mislay the extracellular enzymelactase over time and it also offers us the opportunity to digest lactose, milk's principal sugar. Hypolactasia infects more than 70% of the planet's population, many times it goes unreported and generates mortality. Ayurvedic description of the In Mahodadhi Astyamita Dugdha, a historical treatise on dietary habits, addresses lactose intolerance. Milksensitivity therapy can actually be found in ancient books such as the Charakasamhita, where its disease was not addressed as a result of individuals, but can be seen scattered over and over again. The aim of this paper is to introduce the idea of lactose intolerance with Ayurvedic treatment options.
甚至在主流临床研究开始之前,阿育吠陀似乎对食物及其在保持身体健康和治疗疾病方面的功能有不同的看法。阿育吠陀认为健康的饮食是成功和幸福的基础,而非自然的营养是所有疾病的基础。在阿育吠陀领域,食物被称为rasayana,充满活力等。牛奶也被现代医学视为全脂食品。乳糖不耐症是一种限制人类食用牛奶的疾病。在婴儿期之后,像其他生物一样,随着时间的推移,大多数人类失去了细胞外酶,它也为我们提供了消化乳糖的机会,乳糖是牛奶的主要糖。低乳酸血症感染了地球上70%以上的人口,很多时候它没有被报道并造成死亡。阿育吠陀的描述在Mahodadhi Astyamita Dugdha,一个关于饮食习惯的历史论文,解决乳糖不耐症。乳敏疗法实际上可以在《Charakasamhita》等古书中找到,在这些古书中,乳敏疗法并没有因为个体的原因而得到解决,而是一次又一次地分散开来。本文的目的是介绍与阿育吠陀治疗方案的乳糖不耐症的想法。
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引用次数: 0
Case Study on Eka Kustha- Principle to Practice 依卡库沙个案研究-从原则到实践
Pub Date : 2022-06-30 DOI: 10.31254/jahm.2022.8202
B. Mohanty, S. Das
The disease Kustha Roga occurs due to the vitiation of Vata, Pitta and Kapha Doshas. It shows symptoms like Ugrakandu (Severe itching either generalised or localised), Twaksphutana (breaking or cracking of skin), Kharasparsha and lesions are Vritta (round), Snigdha and Ghana (thick). The colour is Krishna or Shyama Varna (brownish black). EkaKustha(Psoriasis) is one among the wide numbers of Kustha Roga. It is a chronic inflammatory skin disease which usually localised in the extremities, trunk, scalp, hairs, etc. This case study deals with a sixty-five years old male patient suffering from Sarwanga Kandu (itching all over the body), Shyava Aruna Vaivarnyata, patches in Sarwanga, Keshachyuti (hair fall). In this case Ayurvedic formulations of Arogyavardhini Vati (orally), Yashtimandhu Churna, Chandan churna and Yashadapuspha mixed with Shatadhauta Ghrita is given for external application.
疾病Kustha Roga是由于Vata, Pitta和Kapha dosha的破坏而发生的。它表现出乌格拉坎度(全身或局部严重瘙痒)、Twaksphutana(皮肤破裂或开裂)、Kharasparsha等症状,病变为Vritta(圆形)、Snigdha和Ghana(厚)。颜色是Krishna或Shyama Varna(棕黑色)。EkaKustha(牛皮癣)是Kustha Roga众多疾病之一。它是一种慢性炎症性皮肤病,通常局限于四肢、躯干、头皮、头发等部位。本案例研究涉及一名65岁男性患者,患有Sarwanga Kandu(全身瘙痒),Shyava Aruna Vaivarnyata, Sarwanga斑块,Keshachyuti(毛发脱落)。在这种情况下,阿育吠陀配方的Arogyavardhini Vati(口服),Yashtimandhu Churna, Chandan Churna和yashaapuspha与Shatadhauta Ghrita混合用于外用。
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引用次数: 0
Effect of Classical Music on Fetus: A Review 古典音乐对胎儿的影响:综述
Pub Date : 2022-06-30 DOI: 10.31254/jahm.2022.8211
Dr. Sujatashamkuwar, V. Ashokan, Y. Shrivas, Pratibha Baghel, S. Sujata
Even before birth, music may have a significant impact on your child's development. Music stimulates all aspects of a child's growth when they are exposed to it. And doing so at a young age may assist guarantee that your child grows up to be healthy. In several psychological conditions, music therapy is known to be effective, but not much research has been done to ascertain the effect of classical Indian music on psychiatric disorders. The ascendant is the antenatal musical practice. With reference to evidence-based study, the paper supports 5 primary objectives: music therapeutic modulation of pre- and perinatal stress, anxiety, and depression; mental and physical birth planning related to music, including cognitive change, emotional regulation, physical exercise, maintenance of relaxation and discomfort, and social inclusion; music-related bonding and self-efficacy; prenatal sound enhancement. Traditional therapeutic tools include Raga Chikitsa, Vedic chanting, Garbha Sanskara (Learning in the Womb), Time theory of ragas (combining ancient Ayurvedic notions) and Cakra activation (music and breathing approach using ragas). Outcomes in clinical are studied to see how they impact biological, physiological, psychological, chronobiological, as well as spiritual factors.
甚至在出生前,音乐就可能对孩子的发展产生重大影响。当孩子接触音乐时,音乐会刺激他们成长的各个方面。在年轻的时候这样做可以帮助保证你的孩子健康成长。众所周知,在一些心理疾病中,音乐疗法是有效的,但没有太多的研究来确定古典印度音乐对精神疾病的影响。升支是产前的音乐练习。参考循证研究,本文支持5个主要目标:音乐治疗调节产前和围产期压力、焦虑和抑郁;与音乐相关的心理和生理生育计划,包括认知变化、情绪调节、体育锻炼、保持放松和不适以及社会包容;与音乐相关的联系与自我效能;产前声音增强。传统的治疗工具包括拉格奇奇奇萨,吠陀念诵,Garbha Sanskara(在子宫里学习),拉格的时间理论(结合古老的阿育吠陀概念)和脉轮激活(使用拉格的音乐和呼吸方法)。研究临床结果,以了解它们如何影响生物、生理、心理、时间生物学以及精神因素。
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引用次数: 0
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Journal of Ayurvedic and Herbal Medicine
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