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Effect of Saffron (Crocus sativus L) on Common NonCommunicable Disease: Review from Current Clinical Findings 藏红花(Crocus sativus L)对常见非传染性疾病的作用:从目前的临床研究综述
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7208
A. Chowdhury, M. A. Habib, Susmita Ghosh
Background: Due to the high prevalence of NCDs and treatment costs, many medical providers are looking for alternative medications, especially herbal medicine, and some herbal medicines can be used as an effective therapy for the treatment of NCDs. Many studies have shown the effective use of saffron to impede and treat different types of non-communicable diseases. Aim: This current review focuses on the medicinal uses of saffron and current findings relating to the effects of saffron on different types of non-communicable diseases. Methods: Cochrane library, Pub Med, and Google Scholar databases were searched from 2000 to 2020 before September to accumulate current findings with the limitation of the English language. Result: A total of 33 studies (8 human and 25 animalstudies) were identified through searching. Saffron and its active components improved lipid profile along with lowering the risk of cardiovascular disease, hypertension, diabetes, and obesity. Kidney function was also improved by reducing nitrogen urea, urinary citrate, uric acid, etc. Saffron can be also used for treating different types of cancer like prostate cancer, skin cancer, breast cancer, etc. Conclusion: Despite the beneficial effects of saffron on non-communicable diseases, more prospective clinical trials among humans and animals are needed for a better understanding of the effects and mechanisms of saffron and its compounds.
背景:由于非传染性疾病的高患病率和治疗费用,许多医疗提供者正在寻找替代药物,特别是草药,一些草药可以作为治疗非传染性疾病的有效疗法。许多研究表明,藏红花可有效预防和治疗不同类型的非传染性疾病。目的:目前的审查侧重于药用藏红花和目前的发现有关藏红花对不同类型的非传染性疾病的影响。方法:检索Cochrane图书馆、Pub Med和Google Scholar数据库,检索2000年至2020年9月前的文献,积累受英语语言限制的最新研究结果。结果:通过检索共获得33项研究(8项人类研究和25项动物研究)。藏红花及其活性成分改善了血脂,降低了患心血管疾病、高血压、糖尿病和肥胖的风险。通过降低氮素、尿素、柠檬酸、尿酸等,还能改善肾功能。藏红花还可以用于治疗不同类型的癌症,如前列腺癌、皮肤癌、乳腺癌等。结论:尽管藏红花对非传染性疾病有有益作用,但为了更好地了解藏红花及其化合物的作用和机制,还需要在人类和动物中进行更多的前瞻性临床试验。
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引用次数: 2
Traditional Approach to Cure Shingles Using Medicinal Plants in Eastern Nepal 尼泊尔东部使用药用植物治疗带状疱疹的传统方法
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7203
Homnath Khatiwada, Ajay Neupane, L. Thapa
Oral Collection and documentation of indigenous knowledge of local people have an important role in scientific research, biodiversity conservation, and the drug development process. A study was carried out to document the medicinal plants that have been used by the local folk healer to treat Shingles in Ilam district, Eastern Nepal. A renowned folk healer who was involved in curing Shingles for decades and 30 key informants were selected for the interview to know the methods of curing Shingles. Altogether six plants viz: Oroxylum indicum, Cynodon dactylon, Centella asiatica, Drymaria cordata, Sesamum indicum, and Lygodium japonicum were found to be used against the disease. The traditional method of preparing medicine from these plants was found to be highly effective. The finding provides a clue for further extensive lab-based research to isolate the specific compounds that are effective against the disease.
收集和记录当地居民的土著知识在科学研究、生物多样性保护和药物开发过程中具有重要作用。一项研究记录了尼泊尔东部Ilam地区当地民间治疗师用来治疗带状疱疹的药用植物。为了了解带状疱疹的治疗方法,我们选择了一位从事带状疱疹治疗数十年的著名民间治疗师和30名关键线人进行采访。共有6种植物被发现具有抗该病的作用,即:雪草、雪草、积雪草、雪莲、芝麻和枸杞。人们发现用这些植物制药的传统方法非常有效。这一发现为进一步广泛的实验室研究提供了线索,以分离出有效对抗这种疾病的特定化合物。
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引用次数: 1
An updated review on Shankhpushpi- As Medhya Rasayana Shankhpushpi- As Medhya Rasayana的最新评论
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7210
P. Devi
Shankhpushpi is a plant and known as best brain tonic medicine which is classified under four Medhya Rasayana by Acharya Charaka. It is also included as main ingredient in many herbal extractives or decoction-based brain tonics or memory boosting formulations. Various Ayurvedacharya have named it as manglayakusuma, ksheerpushpi, medhya etc. Shankhpushi is also comes under convolvulacea family indicated as Convolvulus pluricaulis. The Charaka Samhita, which is an ancient book of Ayurveda described the use of paste (kalka) as Medhya Rasayana. There are so many experimental, pharmacological, clinical studies done on Convolvulus pluricaulis revealed the promising results as neuroprotective, memory enhancer, and antianxiety properties. The studies analysed its chemical composition like convolidine, convolvine, confoline etc. and may help to stimulate the brain activities. In addition, the studies have shown other properties like diuretic, antioxidant, hypolipidemic, hypotensive, antiulcer, antipyretic which helps to manage the various disorders. The various dosage forms like powder, paste, syrup is prepared by using whole plant or different parts of plant as indicated in classical texts. The present review study on Shankhpushpi basically focused on the experimental or clinical studies done in the management of various ailments.
Shankhpushpi是一种植物,被认为是最好的补脑药物,被阿查里亚·查罗卡(Acharya Charaka)分为四种Medhya Rasayana。它也被包括在许多草药提取物或煎剂为基础的大脑滋补品或记忆增强配方的主要成分。不同的阿育吠陀arya将其命名为manglayakusuma, ksheerpushpi, medhya等。它也属于旋花科,称为旋花。《Charaka Samhita》是阿育吠陀的一本古老的书,它将膏体(kalka)的使用描述为Medhya Rasayana。对旋花进行了大量的实验、药理学和临床研究,揭示了其在神经保护、记忆增强和抗焦虑方面的良好效果。研究分析了其化学成分,如convolidine, convolvine, confoline等,可能有助于刺激大脑活动。此外,研究还显示了其他特性,如利尿剂、抗氧化剂、降血脂、降压、抗溃疡、解热,有助于控制各种疾病。各种剂型,如粉末、糊状、糖浆,是根据经典文献中所述,用整株植物或植物的不同部位制备的。目前对山普皮的综述研究主要集中在治疗各种疾病的实验或临床研究上。
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引用次数: 2
Hepatoprotective activity of Cynodon dactylon leaf extract against rifampicin- induced liver damage in albino rats 利福平对白化大鼠肝损伤的保护作用
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7204
Akshay Javalgikar, N. Mahurkar, K. Keerthi
Liver plays an important role in maintaining the biological equilibrium of vertebrates. Liver diseases are a major worldwide health problem with high endemicity in developing countries. They are mainly caused by chemicals and some drugs when taken in very high doses. Despite advances in modern medicine, there is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. There is urgent need, therefore, for effective drugs to replace/supplement those in current use. The plant kingdom is undoubtedly valuable as a source of new medicinal agents. The main aim of any medication in the treatment of liver disorders is to prevent degeneration of hepatocytes and associated metabolic abnormalities and promote regeneration of hepatic cells. In present study the hepatoprotective activity of Cynodon dactylon extracts was evaluated in rifampicin induced liver toxicity by biochemical parameters like SGPT, SGOT, ALP, BIT and by histopathological study. Acute administration of rifampicin produced marked elevation of the serum levels of the above parameters compared to that of the control group. Treatment with ethanolic and aqueous extracts of Cynodon dactylon leaves at doses of 200 and 400 mg/kg produces significant prevention in rifampicin induced rise of the above parameters. Silymarin at 100 mg/kg body weight significantly prevented such rise in study. The effect of Cynodon dactylon leaves extracts was found possess promising hepatoprotective activity. Further studies in other species and on other parameter would throw more light on this plant.
肝脏在维持脊椎动物的生物平衡中起着重要的作用。肝病是世界范围内的一个主要健康问题,在发展中国家具有很高的地方性。它们主要是由化学物质和一些大剂量服用的药物引起的。尽管现代医学取得了进步,但目前还没有一种有效的药物可以刺激肝脏功能,保护肝脏免受损害,或帮助肝细胞再生。因此,迫切需要有效的药物来替代/补充目前使用的药物。作为新药的来源,植物界无疑是有价值的。治疗肝脏疾病的任何药物的主要目的是防止肝细胞变性和相关的代谢异常,促进肝细胞再生。本研究采用生化指标SGPT、SGOT、ALP、BIT及组织病理学方法,对利福平对大鼠肝毒性的影响进行了评价。与对照组相比,急性给予利福平可显著提高上述血清参数水平。用200和400 mg/kg剂量的醇提液和水提液对利福平诱导的上述参数升高有显著的预防作用。水飞蓟素在100 mg/kg体重组中显著抑制了这种升高。研究发现,短爪蟹叶提取物具有良好的保肝作用。对其他物种和其他参数的进一步研究将使人们对这种植物有更多的了解。
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引用次数: 0
Short and Long term effects of Overeating (Atimatrashan) on health and well-being: A Conceptual Study 暴饮暴食对健康和幸福的短期和长期影响:一项概念性研究
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7205
Unnati A. Chavan, Ayurveda Samhita M.D – Final Year, Narayan R. Sabu
Overeating is the excess food consumed in relation to the energy that an organism expends. Out of various eating disorders overeating from supersize meal portions is termed as Atimatrashan in Ayurveda. In Ayurveda great emphasis has been given on the ideal quantity i.e., ‘matra’ of Aahara which is customized according to individual appetite. While occasional overeating predisposes to various disorders manifested through impaired digestive function, Habitual overeating eventually leads to obesity. Obesity being a state of chronic inflammation predisposes to wide range of diseases including Metabolic syndrome and Cancer. In this context, this paper discusses the Ayurvedic concept of Tridosha Prakop (vitiation of all the three Doshas) with the resulting ailments and Aamvish which is said to be formed as a result of habitual overeating and is thought to be Vishsadrushya (highly toxic) and param asaadhyam (incurable).
暴饮暴食是指与机体消耗的能量相关的过量食物。在各种饮食失调中,过量饮食在阿育吠陀医学中被称为atimatashan。在阿育吠陀中,非常强调理想的量,即根据个人胃口定制的Aahara的“matra”。偶尔暴饮暴食容易导致消化功能受损等各种疾病,而习惯性暴饮暴食最终会导致肥胖。肥胖是一种慢性炎症状态,易患多种疾病,包括代谢综合征和癌症。在此背景下,本文讨论了阿育吠陀的Tridosha Prakop(所有三个dosha的破坏)与由此产生的疾病和Aamvish的概念,据说这是由于习惯性暴饮暴食而形成的,被认为是Vishsadrushya(剧毒)和param asaadhyam(无法治愈)。
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引用次数: 0
Adulteration & Substitution: An Interrupted and Noninterrupted Practices in Medicinal Plants in Ambiguous Herbal World 掺假与替代:模棱两可的草药世界中药用植物的间断与不间断实践
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7212
P. Farzin, Ladani Miral
In India approximately 80% tribal population depends on herbal medicines for their health and proper care to cure disease at first primary level. Generally, these herbal medicines are classified into five different classes. Now a days people are not more worried about Ayurvedic medicines therefore Ayurvedic practitioners become busy professionals like other modern practitioners because preparation of their own medicines requires so much time and its processing is hard enough for patients as well as their family members also. Substitution of Ayurvedic medicines is carried out therefore is carried out Ayurvedic medicines are facings number of problems for different purposes. Ambiguous medicinal plants are those plants which are described very well in classes of Ayurvedic ancient medicines in a well manner but their identification is not yet clear. Based on book related survey these plants are identified and defined by many names. Sometimes one common name is given to two or more than two medicinalplants.Substitution and aduteration are activities that are most often seen in herbal businesses. Aim of th ese practices is mainly found in many large or small commercial firms include Worst mixing with other plant raw m aterials, substitution,addition with great skill, loss of medicinal properties of main drug. Now a day's substitution a nd adulteration is extremely important step in herbal businesses. Therefore there is need for proper methods for their right medicinal plants and herbal medicines.
在印度,大约80%的部落人口依靠草药来维持健康,并在初级一级获得适当的治疗。一般来说,这些草药被分为五类。现在人们不再担心阿育吠陀药物,因此阿育吠陀从业者像其他现代从业者一样成为忙碌的专业人士,因为他们自己的药物准备需要很多时间,而且对病人和他们的家人来说,它的处理也足够困难。阿育吠陀药物的替代是进行的,因此进行阿育吠陀药物面临着许多不同目的的问题。模棱两可的药用植物是那些在阿育吠陀古代药物分类中描述得很好的植物,但它们的鉴定还不清楚。根据与书籍相关的调查,这些植物被识别和定义为许多名称。有时,两种或两种以上的药用植物被赋予一个通用名称。替代和掺假是草药行业中最常见的活动。这些做法的目的主要是在许多大型或小型商业公司发现,包括与其他植物原料混合不良,替代,添加技术高超,失去主要药物的药用特性。现在一天的替代和掺假是草药生意中极其重要的一步。因此,有必要采取适当的方法,对其适当的药用植物和草药。
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引用次数: 0
Lepidium sativum: A potential functional food 枸杞:一种潜在的功能性食品
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7213
M. Shah, Vinisha A. Dudhat, Krupa V. Gadhvi
Lepidium sativum Linn. (family Cruciferae) is an edible herb that is botanically related to watercress and mustard, having their peppery, tangy taste and odour. Traditionally L. sativum seeds are used to treat wounds, sprains, asthma, bronchitis, cough and is considered useful as abortifacient, aphrodisiac, antibacterial, diuretic, expectorant, gastrointestinal stimulant, gastroprotective, laxative and stomachic. Many of these traditional uses have been scientifically validated using different in vitro and in vivo studies and in this review are compiled in an inclusive manner. Seeds are reported to be rich in carbohydrates, vitamins, amino acids, proteins, triterpenoids, steroids and saponin glycosides possessing different pharmacological activities. Aim of the study: This study is an effort to collate complete scientific literature published till March 2021 in order to generate a succinct summation on the distribution, traditional beneficial potential, chemical constituents, phytochemistry, pharmacology and toxicology of this coveted species of genus Lepidium. Materials and Methods: Exploring assorted scientific databases. Results: The present methodically compiled review article accentuates medicinal and nutritional significance of this highly valued plant by focusing on various aspects of the plant such as the, physicochemical characterisation and pharmacological studies that validates folklore uses. Thus, this annotated script on L. sativum would be a handy tool to explore the future prospective of research on this traditional plant.
蛇尾草(十字花科)是一种可食用的草本植物,在植物学上与豆瓣菜和芥末有关,具有辛辣、浓烈的味道和气味。传统上,L. satium种子用于治疗伤口,扭伤,哮喘,支气管炎,咳嗽,并被认为是有用的堕胎药,壮阳药,抗菌,利尿剂,祛痰剂,胃肠兴奋剂,胃保护,泻药和胃。许多这些传统用途已经通过不同的体外和体内研究得到了科学验证,并且在本综述中以包容性的方式编制。据报道,种子富含碳水化合物、维生素、氨基酸、蛋白质、三萜、类固醇和皂苷,具有不同的药理活性。研究目的:本研究旨在整理截至2021年3月发表的完整科学文献,以对这一令人垂涎的Lepidium属物种的分布、传统有益潜力、化学成分、植物化学、药理学和毒理学进行简要总结。材料和方法:探索各种科学数据库。结果:这篇系统的综述文章强调了这种高价值植物的药用和营养意义,重点介绍了这种植物的各个方面,如物理化学特征和药理学研究,验证了民间用途。因此,本文的注释将为探索这一传统植物的未来研究前景提供一个便利的工具。
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引用次数: 8
Observational Case Studies on Effect of Phage-laden Ganga water on Dyspepsia and Diabetes Patients 含噬菌体恒河水治疗消化不良和糖尿病的观察性病例研究
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7202
A. Shukla, B. Jhunjhunwala
12 patients of dyspepsia and diabetes were administered phage-laden Ganga water orally. Of these, the results of 3 patients who took Ganga water in the two rounds continuously indicate substantial and sustained benefit.
12例消化不良和糖尿病患者口服含噬菌体的恒河水。其中,连续两轮服用恒河水的3名患者的结果显示出实质性和持续的益处。
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引用次数: 0
Antimicrobial and Antiasthmatic Properties of Plants 植物的抗菌和平喘特性
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7216
Raveena, Sana Shaheen, R. Mathur, A. Jha
Asthma is a disease that mainly affects our respiratory system. It affects millions of people in the world. It is most common chronic and non-communicable disease in adults as well as children. It is more prevalent in industrialized countries. Asthma is caused by the genetic interaction and environmental factors. The major risk factor for developing asthma is the genetic disposition of individual. Asthma symptoms are caused due to the liberation of endogenous and intrinsic mediators like histamine, nitric oxide, chemokines, inflammation of the airways in the lungs. Therefore, there are many treatments associated with this disease. One of which is the nutraceutical therapy which provides medicinal and health benefits. Indian herbs and plants are well known for its medicinal properties from the ancient times. Allium species, Aloevera, crinum, Licorice, Adhatoda species that possess the antimicrobial activities are known to provide efficient therapeutic response in treating asthma.
哮喘是一种主要影响我们呼吸系统的疾病。它影响着世界上数百万人。它是成人和儿童中最常见的慢性和非传染性疾病。它在工业化国家更为普遍。哮喘是由遗传相互作用和环境因素共同引起的。患哮喘的主要危险因素是个体的遗传倾向。哮喘症状是由于内源性和内在介质如组胺、一氧化氮、趋化因子、肺部气道炎症的释放而引起的。因此,有许多与这种疾病相关的治疗方法。其中之一是提供药物和健康益处的营养疗法。印度草药和植物自古以来就以其药用特性而闻名。已知具有抗菌活性的葱属植物、芦荟、犯罪、甘草、Adhatoda属植物在治疗哮喘方面具有有效的治疗作用。
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引用次数: 0
Precautions in Panchakarma w.s.r. to Parihara Vishaya Panchakarma s.r.到Parihara Vishaya的预防措施
Pub Date : 2021-07-14 DOI: 10.31254/jahm.2021.7214
Swarnakant Jena, PS Arshathjyothi, Prasanth Dharmarajan
Global acceptance of Panchakarma is increasing day by day. It is the duty of responsible Vaidyas that to maintain the essence of the scientific wisdom during this developmental stage. All the procedures have their own precautions and complications specifically mentioned in classics. One who has excellent knowledge as well as practical experience in Panchakarma should perform these procedures with utmost care. If we explore the various classical precautions mentioned in Ayurveda we can find scientific and logical reasons for the advises.So it is the need of the hour to review on the precautions of Panchakarma.A standardised operating procedure should be needed nationally and internationally including necessary precautions for ensuring better clinical practices.Also extensive researches should be done in this area to develop evidence based conclusions.
全球对Panchakarma的接受程度与日俱增。在这一发展阶段保持科学智慧的本质是负责任的维达人的责任。所有的手术都有自己的注意事项和典籍中特别提到的并发症。一个在Panchakarma有卓越的知识和实践经验的人应该非常小心地执行这些程序。如果我们探索阿育吠陀提到的各种经典预防措施,我们可以找到这些建议的科学和逻辑原因。因此,回顾一下Panchakarma的预防措施是必要的。在国内和国际上需要标准化的操作程序,包括必要的预防措施,以确保更好的临床实践。此外,还应在这一领域进行广泛的研究,以得出基于证据的结论。
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引用次数: 0
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Journal of Ayurvedic and Herbal Medicine
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