首页 > 最新文献

Journal of Cellular Biotechnology最新文献

英文 中文
Review of the potential benefits and challenges of artificial intelligence in clinical laboratory 回顾人工智能在临床实验室中的潜在益处和挑战
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-02-03 DOI: 10.3233/jcb-230119
Yugeshwari R. Tiwade, N. Bankar, Vaishnavi Mishra, Anita Sajjanar
Over the past few years, medical artificial intelligence (AI) has been extensively utilized within the healthcare industry. However, the deployment of AI raises complicated social and ethical issues related to security, privacy, and human rights. While the use of artificial intelligence (AI) has the potential to improve healthcare outcomes and operational efficiency, this article gives a detailed assessment of current cutting-edge AI breakthroughs in clinical laboratories. It focuses on the potential benefits of AI and its application in clinical laboratory. The use of AI in clinical laboratory is rapidly growing, with the potential to alter patient care in the near future. Furthermore, it has the potential to democratize modern laboratory services, making them available to people all around the world.
过去几年来,医疗人工智能(AI)在医疗保健行业得到了广泛应用。然而,人工智能的部署引发了与安全、隐私和人权有关的复杂社会和伦理问题。虽然人工智能(AI)的使用具有改善医疗成果和提高运营效率的潜力,但本文对当前临床实验室中最前沿的人工智能突破进行了详细评估。文章重点介绍了人工智能的潜在优势及其在临床实验室中的应用。人工智能在临床实验室中的应用正在迅速增长,有可能在不久的将来改变患者护理。此外,它还有可能实现现代实验室服务的民主化,让世界各地的人们都能获得这些服务。
{"title":"Review of the potential benefits and challenges of artificial intelligence in clinical laboratory","authors":"Yugeshwari R. Tiwade, N. Bankar, Vaishnavi Mishra, Anita Sajjanar","doi":"10.3233/jcb-230119","DOIUrl":"https://doi.org/10.3233/jcb-230119","url":null,"abstract":"Over the past few years, medical artificial intelligence (AI) has been extensively utilized within the healthcare industry. However, the deployment of AI raises complicated social and ethical issues related to security, privacy, and human rights. While the use of artificial intelligence (AI) has the potential to improve healthcare outcomes and operational efficiency, this article gives a detailed assessment of current cutting-edge AI breakthroughs in clinical laboratories. It focuses on the potential benefits of AI and its application in clinical laboratory. The use of AI in clinical laboratory is rapidly growing, with the potential to alter patient care in the near future. Furthermore, it has the potential to democratize modern laboratory services, making them available to people all around the world.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139867467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surfactin production from Bacillus cereus AHMNAZ1 and its potential applications 蜡样芽孢杆菌 AHMNAZ1 生产表面活性剂及其潜在应用
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 DOI: 10.3233/jcb-230122
Alaa Atef, Mostafa M. Abo Elsoud, H. Elkhouly, N. Sidkey
BACKGROUND: Biosurfactants are surfactants derived from several types of microorganisms such as bacteria, yeasts and fungi as membrane components or secondary metabolites. OBJECTIVE: To increase BS productivity as a biocompatible, low-toxic substitute for chemical surfactants employed in modern industry and the huge variety of applications they are used in. METHODS: Different media were used in isolation of the biosurfactant BS producers. The most potent bacterial isolate was analysed by 16S-rRNA. Plackett Burman and Box-Behnken Designs were used for optimization conditions. BS was purified by and characterized. RESULTS: Only one strain demonstrated great BS productivity, excellent emulsifying capability (54.5±0.1%) and oil spreading activity which analysed as Bacillus cereus AHMNAZ1 with accession number OP714421.1. The BS was lipopeptide in nature, identified as a surfactin which was stable and has Critical Micelle Concentration of 60 mg/L. Isolated surfactin showed excellent activity against Colon Carcinoma and Breast Carcinoma cell lines and can be used as antimicrobial agent. CONCLUSION: The study found a cheaper way of creating biosurfactants from agro-industrial wastes, delivering a twofold benefit of lowering environmental pollution and manufacturing useful biotechnological products (biosurfactants) with high activity and thermostability. Moreover, it can be used for the bioremediation of oil-polluted soils and in medical fields.
背景:生物表面活性剂是从细菌、酵母和真菌等几种微生物中提取的表面活性剂,作为膜组分或次生代谢物。目的:提高BS作为生物相容性、低毒的化学表面活性剂在现代工业中广泛应用的替代品的生产效率。方法:采用不同培养基分离生物表面活性剂BS生产者。用16S-rRNA分析最强细菌分离物。采用Plackett Burman设计和Box-Behnken设计进行条件优化。对BS进行了纯化和表征。结果:只有1株芽孢杆菌具有较高的BS产率、良好的乳化能力(54.5±0.1%)和涂油活性,鉴定菌株为蜡样芽孢杆菌AHMNAZ1,菌株编号为OP714421.1。BS本质上为脂肽,是一种稳定的表面蛋白,临界胶束浓度为60 mg/L。分离得到的表面素对结肠癌和乳腺癌细胞株具有良好的抑菌活性,可作为抗菌药物使用。结论:该研究发现了一种从农业工业废物中制造生物表面活性剂的更便宜的方法,提供了降低环境污染和制造具有高活性和热稳定性的有用生物技术产品(生物表面活性剂)的双重效益。此外,它还可用于石油污染土壤的生物修复和医学领域。
{"title":"Surfactin production from Bacillus cereus AHMNAZ1 and its potential applications","authors":"Alaa Atef, Mostafa M. Abo Elsoud, H. Elkhouly, N. Sidkey","doi":"10.3233/jcb-230122","DOIUrl":"https://doi.org/10.3233/jcb-230122","url":null,"abstract":"BACKGROUND: Biosurfactants are surfactants derived from several types of microorganisms such as bacteria, yeasts and fungi as membrane components or secondary metabolites. OBJECTIVE: To increase BS productivity as a biocompatible, low-toxic substitute for chemical surfactants employed in modern industry and the huge variety of applications they are used in. METHODS: Different media were used in isolation of the biosurfactant BS producers. The most potent bacterial isolate was analysed by 16S-rRNA. Plackett Burman and Box-Behnken Designs were used for optimization conditions. BS was purified by and characterized. RESULTS: Only one strain demonstrated great BS productivity, excellent emulsifying capability (54.5±0.1%) and oil spreading activity which analysed as Bacillus cereus AHMNAZ1 with accession number OP714421.1. The BS was lipopeptide in nature, identified as a surfactin which was stable and has Critical Micelle Concentration of 60 mg/L. Isolated surfactin showed excellent activity against Colon Carcinoma and Breast Carcinoma cell lines and can be used as antimicrobial agent. CONCLUSION: The study found a cheaper way of creating biosurfactants from agro-industrial wastes, delivering a twofold benefit of lowering environmental pollution and manufacturing useful biotechnological products (biosurfactants) with high activity and thermostability. Moreover, it can be used for the bioremediation of oil-polluted soils and in medical fields.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":"101 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative DNA damage estimated by urinary 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) and 8-Oxoguanine DNA Glycosylase (OGG1) in cigarette and non-cigarette smokers in South West Nigeria 通过尿液中的 8-羟基-2'-脱氧鸟苷 (8-OHdG) 和 8-氧鸟嘌呤 DNA 糖基化酶 (OGG1) 评估尼日利亚西南部吸烟者和非吸烟者的 DNA 氧化损伤情况
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-12-01 DOI: 10.3233/jcb-230120
A.B. Ajileye, F.O. Akinbo
BACKGROUND: The thousands of chemicals and compounds found in cigarette smoke, including many free radicals and oxidants, can cause oxidative damage to DNA either directly or by producing reactive oxygen species in cultured cells. This study was carried out to analyze the urinary 8-Oxoguanine DNA Glycosylase (OGG1) and 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) among cigarette and non-cigarette smokers in South-West, Nigeria. METHODS: Urine samples were collected from 250 cigarette smokers and 200 non-cigarette smokers who live in south-west, Nigeria. Questionnaire was administered first to both cigarette and non-cigarette smokers prior to specimen collection. About 10mls of urine samples were collected from each of the subjects and was used to carry out Oxoguanine Glycosylase and 8-Hydroxyl-2-deoxyguanosine using spectrophotometer at 450 nm wavelength. RESULTS: There was a significant (P <  0.05) increase in Urinary 8-OHdG (345.84±90.98 vs 223±68.48) and OGG1 (220.71±59.55 vs 97.20±56.14) of the cigarette smokers when compared with that of non-cigarette smokers. CONCLUSION: On the basis of this study, it has been observed and established that indulging in cigarette smoking can result in oxidative stress and DNA damage.
背景:香烟烟雾中发现的数千种化学物质和化合物,包括许多自由基和氧化剂,可以直接或通过在培养细胞中产生活性氧对DNA造成氧化损伤。本研究分析了尼日利亚西南部吸烟和非吸烟人群尿8-氧鸟嘌呤DNA糖基化酶(OGG1)和8-羟基-2′-脱氧鸟嘌呤(8-OHdG)。方法:收集生活在尼日利亚西南部的250名吸烟者和200名非吸烟者的尿液样本。在采集样本之前,首先对吸烟和不吸烟的人进行问卷调查。每人取尿约10ml,用分光光度计测定氧鸟嘌呤糖基化酶和8-羟基-2-脱氧鸟嘌呤,波长450nm。结果:吸烟组尿8-OHdG(345.84±90.98 vs 223±68.48)、OGG1(220.71±59.55 vs 97.20±56.14)较不吸烟组明显升高(P < 0.05)。结论:在本研究的基础上,我们已经观察并确立了沉迷于吸烟会导致氧化应激和DNA损伤。
{"title":"Oxidative DNA damage estimated by urinary 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) and 8-Oxoguanine DNA Glycosylase (OGG1) in cigarette and non-cigarette smokers in South West Nigeria","authors":"A.B. Ajileye, F.O. Akinbo","doi":"10.3233/jcb-230120","DOIUrl":"https://doi.org/10.3233/jcb-230120","url":null,"abstract":"BACKGROUND: The thousands of chemicals and compounds found in cigarette smoke, including many free radicals and oxidants, can cause oxidative damage to DNA either directly or by producing reactive oxygen species in cultured cells. This study was carried out to analyze the urinary 8-Oxoguanine DNA Glycosylase (OGG1) and 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) among cigarette and non-cigarette smokers in South-West, Nigeria. METHODS: Urine samples were collected from 250 cigarette smokers and 200 non-cigarette smokers who live in south-west, Nigeria. Questionnaire was administered first to both cigarette and non-cigarette smokers prior to specimen collection. About 10mls of urine samples were collected from each of the subjects and was used to carry out Oxoguanine Glycosylase and 8-Hydroxyl-2-deoxyguanosine using spectrophotometer at 450 nm wavelength. RESULTS: There was a significant (P <  0.05) increase in Urinary 8-OHdG (345.84±90.98 vs 223±68.48) and OGG1 (220.71±59.55 vs 97.20±56.14) of the cigarette smokers when compared with that of non-cigarette smokers. CONCLUSION: On the basis of this study, it has been observed and established that indulging in cigarette smoking can result in oxidative stress and DNA damage.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic advancement in the detection of Systemic Lupus Erythematosus (SLE) 检测系统性红斑狼疮的基因进步
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-11-17 DOI: 10.3233/jcb-230121
Akshat Pratap Singh, Mohammad Kamran Shaikh, Anjali Borker, Gulshan R Bandre
The disease lupus, also known as systemic lupus erythematosus (SLE), is an autoimmune condition, chronic in nature, that can affect any organ in the body. The immune system of the body becomes hyperactive in lupus, attacking normal tissues and organs such as the skin, skeletal, renal, brain, heart, lungs, and blood. Normally, the immunologic response protects the body against outside susceptibilities. Periods of illness, known as flares, and times of wellness, known as remissions, are characteristics of lupus. Lupus is challenging to diagnose since its symptoms are vastly adherent and often mistaken for those of other illnesses. The presence of complexities in this illness cannot be proven with a single laboratory test. Lupus has no recognised cause or treatment as of yet. However, research is going on to achieve improved health outcomes, and early identification and treatment are essential. Lupus has no recognised cause or treatment as of yet. Early detection and treatment, which can typically reduce a disease’s severity and course, are essential to enhancing health outcomes. NSAIDs, antimalarials, and steroids (including cortisone and others) are widely used to treat lupus. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. This well-known and respected resource has a new edition that blends basic and clinical science to present a translational medicine concept. A helpful resource for professionals in the diagnosis and treatment of Systemic Lupus Erythematous patients, SLE serves as a reference for hospital libraries and as a tool for measuring clinical activity for drug development and fundamental research. Beautifully depicted and in full colour throughout Basic science part has been enhanced to let readers concentrate on the most recent molecular medicine techniques and how they affect the expression and treatment of diseases.
红斑狼疮又称系统性红斑狼疮(SLE),是一种自身免疫性疾病,属于慢性病,可影响身体的任何器官。狼疮患者体内的免疫系统变得异常活跃,攻击正常的组织和器官,如皮肤、骨骼、肾脏、大脑、心脏、肺部和血液。正常情况下,免疫反应会保护人体免受外界易感因素的侵袭。红斑狼疮的特征是患病期(称为发作期)和康复期(称为缓解期)。红斑狼疮的症状多种多样,常常被误认为是其他疾病的症状,因此诊断难度很大。这种疾病的复杂性无法通过单一的实验室检测来证明。红斑狼疮至今没有公认的病因或治疗方法。不过,目前正在开展研究,以改善健康状况,早期识别和治疗至关重要。红斑狼疮目前还没有公认的病因或治疗方法。早期发现和治疗通常可以减轻疾病的严重程度,缩短病程,这对提高健康水平至关重要。非甾体抗炎药、抗疟药和类固醇(包括可的松等)被广泛用于治疗狼疮。狼疮患者也可以接受与治疗癌症的化疗类似的细胞毒性化疗。狼疮患者也可能接受与治疗癌症的化疗类似的细胞毒性化疗。这本广为人知、备受推崇的资料集在新版中融合了基础和临床科学,提出了转化医学的概念。系统性红斑狼疮》是诊断和治疗系统性红斑狼疮患者的专业人士的有用资源,既可作为医院图书馆的参考资料,也可作为衡量药物开发和基础研究临床活动的工具。全书图文并茂,全彩印刷 基础科学部分的内容得到了加强,使读者能够集中了解最新的分子医学技术,以及这些技术如何影响疾病的表达和治疗。
{"title":"Genetic advancement in the detection of Systemic Lupus Erythematosus (SLE)","authors":"Akshat Pratap Singh, Mohammad Kamran Shaikh, Anjali Borker, Gulshan R Bandre","doi":"10.3233/jcb-230121","DOIUrl":"https://doi.org/10.3233/jcb-230121","url":null,"abstract":"The disease lupus, also known as systemic lupus erythematosus (SLE), is an autoimmune condition, chronic in nature, that can affect any organ in the body. The immune system of the body becomes hyperactive in lupus, attacking normal tissues and organs such as the skin, skeletal, renal, brain, heart, lungs, and blood. Normally, the immunologic response protects the body against outside susceptibilities. Periods of illness, known as flares, and times of wellness, known as remissions, are characteristics of lupus. Lupus is challenging to diagnose since its symptoms are vastly adherent and often mistaken for those of other illnesses. The presence of complexities in this illness cannot be proven with a single laboratory test. Lupus has no recognised cause or treatment as of yet. However, research is going on to achieve improved health outcomes, and early identification and treatment are essential. Lupus has no recognised cause or treatment as of yet. Early detection and treatment, which can typically reduce a disease’s severity and course, are essential to enhancing health outcomes. NSAIDs, antimalarials, and steroids (including cortisone and others) are widely used to treat lupus. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. This well-known and respected resource has a new edition that blends basic and clinical science to present a translational medicine concept. A helpful resource for professionals in the diagnosis and treatment of Systemic Lupus Erythematous patients, SLE serves as a reference for hospital libraries and as a tool for measuring clinical activity for drug development and fundamental research. Beautifully depicted and in full colour throughout Basic science part has been enhanced to let readers concentrate on the most recent molecular medicine techniques and how they affect the expression and treatment of diseases.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139265346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the clinical parameters and volumetric analysis of gingival crevicular fluid for chlohexidine vying silver nanoparticle mouthwash the avant garde for chronic periodontitis 氯己定与纳米银漱口水的临床参数评价及龈沟液容量分析
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-08-18 DOI: 10.3233/jcb-230116
Shivani Sachdeva, Amit Mani, H. Saluja, R. Kunkulol, Navid Mohammadi, Deepak Abhaya
BACKGROUND: Oral cavity ecosystem represents a dynamic pattern. Scaling and root planing (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Although chlorhexidine is the most effective mouthwash against oral microorganisms, the side effects of long- term use suggest the need for an alternative. Hence, this study has been undertaken to know effectiveness of silver nanoparticle mouthwash with chlorhexidine mouthwash which is effective on common microorganisms of oral cavity. OBJECTIVE: To evaluate and compare the clinical and biochemical outcome of chlorhexidine (CHX) and silver nanoparticle as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis. METHODS: Ninety- two patients with generalized moderate to severe chronic periodontitis from the Dept. of Periodontology who fulfilled the inclusion and exclusion criteria were recruited for the study. In the experimental clinical trial, the clinical parameters likewise; Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. The volumetric analysis of gingival crevicular fluid (GCF) levels were assessed at baseline and follow up visits. The IBM SPSS Statistics for Windows software, v. 20.0 (IBM Corp., Armonk, USA), was used. The data was numerically coded and entered into the program. Both the descriptive statistics and the inferential statistics were analyzed to compare the responses between the groups. RESULTS: The statistical analysis was carried out by descriptive as well as inferential statistics and both groups demonstrated significant intragroup reduction in PI, GI, PPD, CAL, GCF from baseline to 3 months follow-up. There were statistically significant intragroup differences between both the groups for all of the parameters. CONCLUSION: Silver nanoparticle mouthwash can be an alternative adjunct for non-surgical periodontal therapy in patients with chronic periodontitis. Results of this study indicated that both the mouth rinse demonstrated an equal range of effectiveness. These conclusions were supported by the clinical parameters and biochemical outcomes.
背景:口腔生态系统是一个动态格局。除垢和牙根刨平(SRP)是治疗慢性牙周炎的金标准方法,但单独使用它可能无法有效地从难以进入的部位清除牙周病原体。虽然氯己定是对抗口腔微生物最有效的漱口水,但长期使用的副作用表明需要另一种漱口水。因此,本研究旨在了解纳米银漱口水与氯己定漱口水对口腔常见微生物的有效性。目的:评价和比较氯己定(CHX)和纳米银颗粒辅助刮治和根规划(SRP)治疗慢性牙周炎患者的临床和生化结果。方法:从牙周病科招募92例符合纳入和排除标准的广泛性中重度慢性牙周炎患者进行研究。在实验性临床试验中,临床参数也同样如此;评估菌斑指数(PI)、牙龈指数(GI)、探诊深度(PD)、临床附着损失(CAL)。在基线和随访时评估牙龈沟液(GCF)水平的容量分析。使用IBM SPSS Statistics for Windows软件,v. 20.0 (IBM Corp., Armonk, USA)。数据被数字编码并输入到程序中。采用描述性统计和推断性统计比较两组间的反应。结果:采用描述性统计和推断性统计进行统计分析,两组患者PI、GI、PPD、CAL、GCF从基线到随访3个月均有组内显著降低。两组间所有参数的组内差异均有统计学意义。结论:纳米银漱口水可作为慢性牙周炎非手术治疗的辅助手段。这项研究的结果表明,这两种漱口水显示出相同的有效性范围。这些结论得到了临床指标和生化指标的支持。
{"title":"Evaluation of the clinical parameters and volumetric analysis of gingival crevicular fluid for chlohexidine vying silver nanoparticle mouthwash the avant garde for chronic periodontitis","authors":"Shivani Sachdeva, Amit Mani, H. Saluja, R. Kunkulol, Navid Mohammadi, Deepak Abhaya","doi":"10.3233/jcb-230116","DOIUrl":"https://doi.org/10.3233/jcb-230116","url":null,"abstract":"BACKGROUND: Oral cavity ecosystem represents a dynamic pattern. Scaling and root planing (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Although chlorhexidine is the most effective mouthwash against oral microorganisms, the side effects of long- term use suggest the need for an alternative. Hence, this study has been undertaken to know effectiveness of silver nanoparticle mouthwash with chlorhexidine mouthwash which is effective on common microorganisms of oral cavity. OBJECTIVE: To evaluate and compare the clinical and biochemical outcome of chlorhexidine (CHX) and silver nanoparticle as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis. METHODS: Ninety- two patients with generalized moderate to severe chronic periodontitis from the Dept. of Periodontology who fulfilled the inclusion and exclusion criteria were recruited for the study. In the experimental clinical trial, the clinical parameters likewise; Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. The volumetric analysis of gingival crevicular fluid (GCF) levels were assessed at baseline and follow up visits. The IBM SPSS Statistics for Windows software, v. 20.0 (IBM Corp., Armonk, USA), was used. The data was numerically coded and entered into the program. Both the descriptive statistics and the inferential statistics were analyzed to compare the responses between the groups. RESULTS: The statistical analysis was carried out by descriptive as well as inferential statistics and both groups demonstrated significant intragroup reduction in PI, GI, PPD, CAL, GCF from baseline to 3 months follow-up. There were statistically significant intragroup differences between both the groups for all of the parameters. CONCLUSION: Silver nanoparticle mouthwash can be an alternative adjunct for non-surgical periodontal therapy in patients with chronic periodontitis. Results of this study indicated that both the mouth rinse demonstrated an equal range of effectiveness. These conclusions were supported by the clinical parameters and biochemical outcomes.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47194704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence changing the future of healthcare diagnostics 人工智能改变医疗诊断的未来
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-08-18 DOI: 10.3233/jcb-230118
Vaishnavi Mishra, Sarita Ugemuge, Yugeshwari R. Tiwade
Artificial intelligence (AI) is a computer’s capacity to carry out operations like speech and image recognition and decision-making that ordinarily require human intelligence. Healthcare is using AI to automate tasks such as medical image analysis and diagnosis that require high precision and accuracy. The healthcare industry is significantly impacted by the rapid development of machine learning algorithms, which are frequently implemented using deep learning, as well as the growth of digital data and computing power supported by improvements in hardware technologies. Significant progress has been made in the field of artificial intelligence in recent years and is now widely used in healthcare to automate a variety of tasks, which require a high degree of accuracy and precision. The creation of machine learning algorithms, which can learn from data and make predictions based on that learning, has made it possible to use AI in healthcare. Neural networks are used in deep learning, a subfield of machine learning, to simulate how the human brain functions. Crucial advances have been made in clinical decision support, drug discovery, and medical imaging. Furthermore, the rapid development of hardware technologies, such as graphics processing units, has allowed AI systems to process enormous amounts of data quickly and accurately. Due to this, AI-based tools and platforms can help healthcare professionals with tasks such as patient monitoring, disease diagnosis, and treatment planning.
人工智能(AI)是一种计算机执行语音、图像识别和决策等通常需要人类智能的操作的能力。医疗保健正在使用人工智能来自动化医疗图像分析和诊断等需要高精度和准确性的任务。医疗保健行业受到机器学习算法的快速发展的重大影响,机器学习算法经常使用深度学习来实现,以及硬件技术改进所支持的数字数据和计算能力的增长。近年来,人工智能领域取得了重大进展,目前已广泛应用于医疗保健领域,以实现各种任务的自动化,这些任务需要高度的准确性和准确性。机器学习算法的创建,可以从数据中学习并根据学习做出预测,使人工智能在医疗保健中的应用成为可能。神经网络用于机器学习的子领域深度学习,以模拟人脑的功能。在临床决策支持、药物发现和医学成像方面取得了至关重要的进展。此外,图形处理单元等硬件技术的快速发展使人工智能系统能够快速准确地处理大量数据。因此,基于人工智能的工具和平台可以帮助医疗保健专业人员完成患者监测、疾病诊断和治疗计划等任务。
{"title":"Artificial intelligence changing the future of healthcare diagnostics","authors":"Vaishnavi Mishra, Sarita Ugemuge, Yugeshwari R. Tiwade","doi":"10.3233/jcb-230118","DOIUrl":"https://doi.org/10.3233/jcb-230118","url":null,"abstract":"Artificial intelligence (AI) is a computer’s capacity to carry out operations like speech and image recognition and decision-making that ordinarily require human intelligence. Healthcare is using AI to automate tasks such as medical image analysis and diagnosis that require high precision and accuracy. The healthcare industry is significantly impacted by the rapid development of machine learning algorithms, which are frequently implemented using deep learning, as well as the growth of digital data and computing power supported by improvements in hardware technologies. Significant progress has been made in the field of artificial intelligence in recent years and is now widely used in healthcare to automate a variety of tasks, which require a high degree of accuracy and precision. The creation of machine learning algorithms, which can learn from data and make predictions based on that learning, has made it possible to use AI in healthcare. Neural networks are used in deep learning, a subfield of machine learning, to simulate how the human brain functions. Crucial advances have been made in clinical decision support, drug discovery, and medical imaging. Furthermore, the rapid development of hardware technologies, such as graphics processing units, has allowed AI systems to process enormous amounts of data quickly and accurately. Due to this, AI-based tools and platforms can help healthcare professionals with tasks such as patient monitoring, disease diagnosis, and treatment planning.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44009742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immunohistochemistry in pathology: A review 免疫组织化学在病理学中的应用综述
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-08-04 DOI: 10.3233/jcb-230110
M. Kohale, Anupama V Dhobale, N. Bankar, Obaid Noman, Kajal Hatgaonkar, Vaishnavi Mishra
Immunohistochemistry (IHC) is an invaluable technique in pathology that allows for the localization and characterization of specific antigens within tissues using specific antibodies. Over the years, IHC has revolutionized the field of diagnostic pathology, providing critical information about the molecular and cellular composition of tissues. This comprehensive review article aims to provide an overview of the principles, methodologies, applications, and challenges of IHC in pathology. Immunohistochemistry (IHC) is a vital technique in pathology that allows for the detection and visualization of specific antigens within tissue samples. This article provides an overview of the principles, methodology, and applications of IHC in pathology. The principles of immunoreactivity, antibody selection, and detection methods are discussed, highlighting their importance in achieving accurate and reliable results. The methodology of IHC, including tissue preparation, antigen retrieval, and visualization techniques, is outlined to guide researchers and pathologists in implementing the technique effectively. The article also explores the role of antibodies in IHC, emphasizing the differences between monoclonal and polyclonal antibodies, as well as the significance of antibody validation and quality control. The applications of IHC in pathology are described, ranging from tumor classification and prognostic assessments to the detection of infectious agents and the characterization of autoimmune diseases. Furthermore, the article examines advancements and challenges in IHC, such as multiplex staining, digital pathology, quality control, and interpretation. Finally, emerging techniques, including the integration of next-generation sequencing and artificial intelligence, are discussed as future perspectives for IHC. Overall, this comprehensive overview demonstrates the indispensable role of IHC in pathology and its continuous evolution to meet the ever-expanding needs of diagnostic and research endeavors.
免疫组织化学(IHC)是病理学中一种非常宝贵的技术,可以使用特异性抗体在组织内定位和表征特异性抗原。多年来,IHC彻底改变了诊断病理学领域,提供了有关组织分子和细胞组成的关键信息。这篇综合综述文章旨在概述IHC在病理学中的原则、方法、应用和挑战。免疫组织化学(IHC)是病理学中的一项重要技术,可以检测和可视化组织样本中的特异性抗原。本文概述了IHC在病理学中的原理、方法和应用。讨论了免疫反应性、抗体选择和检测方法的原理,强调了它们在获得准确可靠结果方面的重要性。概述了IHC的方法,包括组织制备、抗原提取和可视化技术,以指导研究人员和病理学家有效实施该技术。文章还探讨了抗体在IHC中的作用,强调了单克隆抗体和多克隆抗体之间的差异,以及抗体验证和质量控制的重要性。介绍了IHC在病理学中的应用,从肿瘤分类和预后评估到感染源的检测和自身免疫性疾病的表征。此外,本文还探讨了IHC的进展和挑战,如多重染色、数字病理学、质量控制和解释。最后,讨论了新兴技术,包括下一代测序和人工智能的集成,作为IHC的未来前景。总的来说,这一全面的综述证明了IHC在病理学中不可或缺的作用,以及它的不断发展,以满足诊断和研究工作不断扩大的需求。
{"title":"Immunohistochemistry in pathology: A review","authors":"M. Kohale, Anupama V Dhobale, N. Bankar, Obaid Noman, Kajal Hatgaonkar, Vaishnavi Mishra","doi":"10.3233/jcb-230110","DOIUrl":"https://doi.org/10.3233/jcb-230110","url":null,"abstract":"Immunohistochemistry (IHC) is an invaluable technique in pathology that allows for the localization and characterization of specific antigens within tissues using specific antibodies. Over the years, IHC has revolutionized the field of diagnostic pathology, providing critical information about the molecular and cellular composition of tissues. This comprehensive review article aims to provide an overview of the principles, methodologies, applications, and challenges of IHC in pathology. Immunohistochemistry (IHC) is a vital technique in pathology that allows for the detection and visualization of specific antigens within tissue samples. This article provides an overview of the principles, methodology, and applications of IHC in pathology. The principles of immunoreactivity, antibody selection, and detection methods are discussed, highlighting their importance in achieving accurate and reliable results. The methodology of IHC, including tissue preparation, antigen retrieval, and visualization techniques, is outlined to guide researchers and pathologists in implementing the technique effectively. The article also explores the role of antibodies in IHC, emphasizing the differences between monoclonal and polyclonal antibodies, as well as the significance of antibody validation and quality control. The applications of IHC in pathology are described, ranging from tumor classification and prognostic assessments to the detection of infectious agents and the characterization of autoimmune diseases. Furthermore, the article examines advancements and challenges in IHC, such as multiplex staining, digital pathology, quality control, and interpretation. Finally, emerging techniques, including the integration of next-generation sequencing and artificial intelligence, are discussed as future perspectives for IHC. Overall, this comprehensive overview demonstrates the indispensable role of IHC in pathology and its continuous evolution to meet the ever-expanding needs of diagnostic and research endeavors.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42076090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemorrheological changes in arterial hypertension in persons with and without COVID-19 新冠肺炎感染者和非感染者动脉高血压的血液流变学变化
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-08-04 DOI: 10.3233/jcb-230113
A. Muravyov, A. Priezzhev, I. Tikhomirova, A. Lugovtsov, P. V. Mikhailov
BACKGROUND: Vascular resistance, and therefore blood pressure (BP), depends on vascular and rheological factors. Microrheological characteristics of red blood cells (RBCs) can affect blood viscosity (BV) and thus be included in the pathogenesis of increased blood pressure in arterial hypertension (AH). Signaling molecules such as gasotransmitters (NO, CO and H2S) regulate vascular tone and RBC microrheological characteristics and thus affect blood pressure and tissue perfusion. OBJECTIVE: It was evaluated the changes in the macro- and microrheological characteristics of blood and red blood cells (RBCs) under arterial hypertension in persons with and without COVID-19, as well as the protective effect of NO and H2S donors on the RBC microrheological properties. METHODS: Hemorheological profile parameters were recorded in group 1 individuals (n = 18, 9 women and 9 men) without a history of COVID-19; group 2 (n = 16; 11 females and 5 males), hypertensive patients who had COVID-19. As a control, there was a group of healthy individuals (group 3 n = 22). In experiments with red blood cells (RBCs) and their recovered ghosts (filled with an isotonic solution of known viscosity), deformability (RBCD) and aggregation (RBCA) were recorded after incubation of cells with sodium nitroprusside (SNP, 100μM) and sodium hydrosulfide (NaHS, 100μM). RESULTS: In patients with AH in both groups, the main parameters of the hemorheological profile were negatively changed, including a decrease in RBCD and an increase in BV, plasma viscosity (PV) and RBCA. SNP and NaHS significantly increased deformability and reduced their aggregation (p <  0.01). However, in healthy individuals, microrheological responses to GT donors (100μM) were more pronounced than in patients with AH, especially in the AH+COVID-19 group (p <  0.05). CONCLUSION: Both gasotransmitter donors (NO and H2S) have a positive effect on the RBC microrheological characteristics in healthy and sick individuals. However in hypertensive patients, especially those who had COVID-19, microrheological responses to GT donors were significantly lower. Therefore, on the model of red cell microrheological responses, as on a test object, it is possible to determine the decrease in the sensitivity of cells and tissues to the regulatory action of gasotransmitters.
背景:血管阻力和血压取决于血管和流变因素。红细胞(RBCs)的微流变特性会影响血液粘度(BV),从而参与动脉高压(AH)血压升高的发病机制。信号分子如气体发射器(NO、CO和H2S)调节血管张力和红细胞微流变特性,从而影响血压和组织灌注。目的:评价新冠肺炎患者和非新冠肺炎患者动脉高压状态下血液和红细胞宏观和微观流变学特征的变化,以及NO和H2S供体对红细胞微观流变学特性的保护作用。方法:记录第1组(n = 18、9名女性和9名男性)没有新冠肺炎病史;第2组(n = 16;11名女性和5名男性)、患有新冠肺炎的高血压患者。作为对照,有一组健康个体(第3组n = 22)。在用红细胞(RBCs)及其回收的重影(用已知粘度的等渗溶液填充)进行的实验中,在用硝普钠(SNP,100μM)和硫化钠(NaHS,100μM)孵育细胞后,记录细胞的变形能力(RBCD)和聚集性(RBCA)。结果:两组AH患者的血液流变学主要参数均呈负变化,包括RBCD降低,BV、血浆粘度(PV)和RBCA升高。SNP和NaHS显著增加了变形能力并减少了它们的聚集(p <  然而,在健康个体中,对GT供体(100μM)的微流变反应比AH患者更显著,尤其是在AH+neneneba COVID-19组(p <  结论:NO和H2S对健康和患病个体红细胞微流变学特性均有积极影响。然而,在高血压患者中,尤其是那些患有新冠肺炎的患者,对GT供体的微流变反应显著降低。因此,在红细胞微流变反应模型上,就像在测试对象上一样,可以确定细胞和组织对气体发射器调节作用的敏感性降低。
{"title":"Hemorrheological changes in arterial hypertension in persons with and without COVID-19","authors":"A. Muravyov, A. Priezzhev, I. Tikhomirova, A. Lugovtsov, P. V. Mikhailov","doi":"10.3233/jcb-230113","DOIUrl":"https://doi.org/10.3233/jcb-230113","url":null,"abstract":"BACKGROUND: Vascular resistance, and therefore blood pressure (BP), depends on vascular and rheological factors. Microrheological characteristics of red blood cells (RBCs) can affect blood viscosity (BV) and thus be included in the pathogenesis of increased blood pressure in arterial hypertension (AH). Signaling molecules such as gasotransmitters (NO, CO and H2S) regulate vascular tone and RBC microrheological characteristics and thus affect blood pressure and tissue perfusion. OBJECTIVE: It was evaluated the changes in the macro- and microrheological characteristics of blood and red blood cells (RBCs) under arterial hypertension in persons with and without COVID-19, as well as the protective effect of NO and H2S donors on the RBC microrheological properties. METHODS: Hemorheological profile parameters were recorded in group 1 individuals (n = 18, 9 women and 9 men) without a history of COVID-19; group 2 (n = 16; 11 females and 5 males), hypertensive patients who had COVID-19. As a control, there was a group of healthy individuals (group 3 n = 22). In experiments with red blood cells (RBCs) and their recovered ghosts (filled with an isotonic solution of known viscosity), deformability (RBCD) and aggregation (RBCA) were recorded after incubation of cells with sodium nitroprusside (SNP, 100μM) and sodium hydrosulfide (NaHS, 100μM). RESULTS: In patients with AH in both groups, the main parameters of the hemorheological profile were negatively changed, including a decrease in RBCD and an increase in BV, plasma viscosity (PV) and RBCA. SNP and NaHS significantly increased deformability and reduced their aggregation (p <  0.01). However, in healthy individuals, microrheological responses to GT donors (100μM) were more pronounced than in patients with AH, especially in the AH+COVID-19 group (p <  0.05). CONCLUSION: Both gasotransmitter donors (NO and H2S) have a positive effect on the RBC microrheological characteristics in healthy and sick individuals. However in hypertensive patients, especially those who had COVID-19, microrheological responses to GT donors were significantly lower. Therefore, on the model of red cell microrheological responses, as on a test object, it is possible to determine the decrease in the sensitivity of cells and tissues to the regulatory action of gasotransmitters.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49556213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ozonized hydrogels for clinical and domiciliary management in periodontal regenerative therapy an annotation 臭氧水凝胶用于牙周再生治疗的临床和家庭管理
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-06-23 DOI: 10.3233/jcb-230101
Shivani Sachdeva, Amit Mani, H. Saluja, A. Chatterjee
OBJECTIVE: The therapeutic application of ozone and its derivatives in the dental field has been used for many purposes. However, there has yet to be a consistent evaluation of the outcomes, due to the lack of standardization of the treatment operating procedures. MATERIALS AND METHODS: The keywords “ozone”, “ozonated”, “ozonation” “ozonized”, “ozonization”, “dentistry”, “periodontology”, “oral surgery”, “oxygen-ozone therapy” was used to perform a literature review using PubMed, Cochrane, Google Scholar databases with the temporal restriction for manuscripts published between 2000 and 2020. Clinical trials and case reports of good, neutral, as well as negative results related to ozone treatment specifications were evaluated. DISCUSSION: A better understanding of the mechanisms of action of this bio-oxidative therapy could open new horizons related to the personalization of treatments and the quality of dental care. The critical condition to achieve these goals is an improved knowledge of the qualitative/quantitative characteristics of ozone and its derivatives. CONCLUSION: Considering the advantages of the ozone therapy in both gingivitis and periodontitis over gold standard chlorhexidine can help to build up a ladder of its use topically.
目的:臭氧及其衍生物在牙科领域的治疗应用具有多种用途。然而,由于治疗操作程序缺乏标准化,尚未对结果进行一致的评估。材料和方法:使用PubMed、Cochrane和Google Scholar数据库,使用关键词“臭氧”、“臭氧氧化”、“臭氧化”、臭氧氧化、“臭氧化”、“牙科”、“牙周病学”、“口腔外科”、“氧-臭氧疗法”对2000年至2020年间发表的手稿进行时间限制的文献综述。评估了与臭氧治疗规范相关的良好、中性和阴性结果的临床试验和病例报告。讨论:更好地了解这种生物氧化疗法的作用机制,可以为个性化治疗和牙科护理质量开辟新的视野。实现这些目标的关键条件是提高对臭氧及其衍生物的定性/定量特征的认识。结论:与金标准洗必泰相比,臭氧治疗牙龈炎和牙周炎的优势有助于建立其局部使用的阶梯。
{"title":"Ozonized hydrogels for clinical and domiciliary management in periodontal regenerative therapy an annotation","authors":"Shivani Sachdeva, Amit Mani, H. Saluja, A. Chatterjee","doi":"10.3233/jcb-230101","DOIUrl":"https://doi.org/10.3233/jcb-230101","url":null,"abstract":"OBJECTIVE: The therapeutic application of ozone and its derivatives in the dental field has been used for many purposes. However, there has yet to be a consistent evaluation of the outcomes, due to the lack of standardization of the treatment operating procedures. MATERIALS AND METHODS: The keywords “ozone”, “ozonated”, “ozonation” “ozonized”, “ozonization”, “dentistry”, “periodontology”, “oral surgery”, “oxygen-ozone therapy” was used to perform a literature review using PubMed, Cochrane, Google Scholar databases with the temporal restriction for manuscripts published between 2000 and 2020. Clinical trials and case reports of good, neutral, as well as negative results related to ozone treatment specifications were evaluated. DISCUSSION: A better understanding of the mechanisms of action of this bio-oxidative therapy could open new horizons related to the personalization of treatments and the quality of dental care. The critical condition to achieve these goals is an improved knowledge of the qualitative/quantitative characteristics of ozone and its derivatives. CONCLUSION: Considering the advantages of the ozone therapy in both gingivitis and periodontitis over gold standard chlorhexidine can help to build up a ladder of its use topically.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41527389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue engineering in periodontal regeneration: A future paradigm in inflammatory disorder 组织工程在牙周再生中的应用:炎症性疾病的未来范例
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-05-17 DOI: 10.3233/jcb-230099
Shivani Sachdeva, H. Saluja, Amit Mani
Periodontitis is an inflammatory disorder that results in tissue destruction when there are too many germs present or when the host’s normal inflammatory response is disrupted. The fight against periodontal regeneration is a titanic one. Tissue engineering was suggested by Langer and colleagues as a potential method for replacing the missing periodontal tissues. The development of functional and long-lasting periodontal tissues will take the role of sick tissues thanks to the science of tissue engineering, which combines engineering and the life sciences. Tissue engineering is an emerging specialisation in the realm of medical health and sciences. It is advancing, spreading its wings over numerous facets of molecular biology, physiology, surgery, regeneration, and molecular medicine. Cell biologists, molecular biologists, biomaterial engineers, experts in microscopic imaging, robotics engineers, computer-assisted designers, and developers of equipment such as bioreactors, where tissues are grown and nurtured, are just a few of the medical and technical specialties that make up the field. Finally, legal advisors and marketing research specialists (product development, and medical implementation) are also involved in the practical process of tissue engineering. New biological organs will be created in the future using engineering and biological techniques.
牙周炎是一种炎症性疾病,当存在太多细菌或宿主的正常炎症反应被破坏时,会导致组织破坏。对抗牙周再生是一场巨大的斗争。Langer及其同事提出组织工程是替换缺失牙周组织的一种潜在方法。由于组织工程科学结合了工程和生命科学,功能性和持久性牙周组织的开发将扮演患病组织的角色。组织工程是医学健康和科学领域的一个新兴专业。它正在进步,在分子生物学、生理学、外科学、再生和分子医学的许多方面展开翅膀。细胞生物学家、分子生物学家、生物材料工程师、显微成像专家、机器人工程师、计算机辅助设计师以及生物反应器等设备的开发人员,这些设备是组织生长和培育的地方,只是该领域的少数医学和技术专业。最后,法律顾问和市场研究专家(产品开发和医疗实施)也参与组织工程的实践过程。未来将利用工程和生物技术创造新的生物器官。
{"title":"Tissue engineering in periodontal regeneration: A future paradigm in inflammatory disorder","authors":"Shivani Sachdeva, H. Saluja, Amit Mani","doi":"10.3233/jcb-230099","DOIUrl":"https://doi.org/10.3233/jcb-230099","url":null,"abstract":"Periodontitis is an inflammatory disorder that results in tissue destruction when there are too many germs present or when the host’s normal inflammatory response is disrupted. The fight against periodontal regeneration is a titanic one. Tissue engineering was suggested by Langer and colleagues as a potential method for replacing the missing periodontal tissues. The development of functional and long-lasting periodontal tissues will take the role of sick tissues thanks to the science of tissue engineering, which combines engineering and the life sciences. Tissue engineering is an emerging specialisation in the realm of medical health and sciences. It is advancing, spreading its wings over numerous facets of molecular biology, physiology, surgery, regeneration, and molecular medicine. Cell biologists, molecular biologists, biomaterial engineers, experts in microscopic imaging, robotics engineers, computer-assisted designers, and developers of equipment such as bioreactors, where tissues are grown and nurtured, are just a few of the medical and technical specialties that make up the field. Finally, legal advisors and marketing research specialists (product development, and medical implementation) are also involved in the practical process of tissue engineering. New biological organs will be created in the future using engineering and biological techniques.","PeriodicalId":15286,"journal":{"name":"Journal of Cellular Biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46969552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Cellular Biotechnology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1