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Nagapashana Pishti - A Potent Cardio Tonic Nagapashana Pishti -一种强有力的心脏强化剂
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.32
Vidya Amr, Chaitra Lv, Jeevesh Kb
Nagapashana (Serpentine), a hydrous silicate of Magnesium (Mg6 (Sio10) OH8), is an important mineral drug used in Ayurveda, often in the form of Pishti (fine powder of Nagapashana). It is a Hrudya Dravya (cardiotonic). It is particularly indicated in Hrud Dourbalyaa, a condition associated with weakness of cardiac muscles. Cardiovascular disease is a leading cause of death in developed and developing countries. The present study was conducted to evaluate the cardio tonic activity of Nagapashana Pishti on Wistar rats. In the in-vivo study, Doxorubicin (2mg/kg) for 7 days was used to induce cardiac damage and the cardio tonic effect of Nagapashana Pishti at a dose of 150 and 300 mg/kg.b.w, was compared with standard drug Digoxin. Biochemical assays like serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), Total Cholesterol (TC), Triglyceride (TG) and Creatine kinase Monoenzyme B (CKMB) were done together with histopathology of heart tissue and ECG analysis. The in-vivo study revealed that Nagapashana Pishti (300mg/kg) was relatively more effective due to decreased QT and ST interval in ECG, significantly reduced levels of serum CKMB, SGOT, SGPT, TC and LDH and improvement in myocardial tissue.
蛇纹石(Nagapashana)是一种镁(Mg6 (Sio10) OH8)的水合硅酸盐,是阿育吠陀中使用的重要矿物药物,通常以Pishti (Nagapashana的细粉末)的形式出现。这是一个Hrudya Dravya(强心剂)。它特别适用于与心肌无力相关的hud Dourbalyaa。心血管疾病是发达国家和发展中国家的主要死亡原因。本研究对Wistar大鼠进行了Nagapashana Pishti健心活动的评价。在体内研究中,用多柔比星(2mg/kg)连续7天诱导心脏损伤,用150和300 mg/kg剂量的那加帕沙那普什提诱导心脏强直作用。w,与标准药物地高辛进行比较。测定血清谷草转氨酶(SGOT)、谷丙转氨酶(SGPT)、乳酸脱氢酶(LDH)、总胆固醇(TC)、甘油三酯(TG)、肌酸激酶单酶B (CKMB)等生化指标,并进行心脏组织病理学检查和心电图分析。体内研究显示,Nagapashana Pishti (300mg/kg)相对更有效,可缩短心电图QT间期和ST间期,显著降低血清CKMB、SGOT、SGPT、TC和LDH水平,改善心肌组织。
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引用次数: 0
Pharmaceutico - Analytical study of Durvadya Taila and its conversion into cream 药剂学——杜尔瓦迪亚及其转化乳膏的分析研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.33
Baban Rathod, Gangaprasad R. Asore, S. Sankpal
Durvadya Taila is medicated oil used in Ayurveda for Kacchu, Vicharchika and Pama (types of Skin diseases) which is caused by vitiated Kapha or Pitta Dosha. Durva is one of the classical drugs of herbal origin, for the management of different disease conditions. The aim of the present study is to do physico-chemical standards for above Durvadya Taila and its conversion into Durvadya Taila Cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Taila or cream. In present article, we are trying to study analytical results of Durvadya Taila w.s.r. to Durvadya Taila cream. The skin constitutes a major part of the body and serves as a dividing line between the individual and his environment. In the Ayurvedic classics, Bahir Parimarjana means, the medicine intended for external use only. For that purpose, in Ayurveda different forms of external applications are described for the convenience of treatment of different diseases. They are Lepa, Udvartana, Upanaha, Abhyanga, Malahara etc. Without defining creams under Panchavidha Kashaya Kalpana, we can correlate Cream preparation with Lepa or Malahara Kalpana. Creams are those emulsions, which are either oil in-water or water-in-oil type. Durvadya Taila is medicated oil used in Ayurveda for Kacchu, Vicharchika and Pama which comes under Kushtha Rogadhikar.
Durvadya Taila是阿育吠陀中用于治疗由Kapha或Pitta Dosha恶化引起的Kacchu, Vicharchika和Pama(皮肤病类型)的药用油。杜尔瓦是一种经典的草药,用于治疗不同的疾病。本研究的目的是对上述杜尔瓦迪亚泰拉进行理化标准,并将其转化为杜尔瓦迪亚泰拉乳膏。从药学的角度来看,这两种制剂与通常的泰拉或乳膏相比具有特殊的重要性。本文对杜尔瓦迪亚乳膏的分析结果进行了研究。皮肤是身体的主要部分,是个体和环境之间的分界线。在阿育吠陀经典中,Bahir Parimarjana的意思是,仅供外用的药物。为此目的,在阿育吠陀中描述了不同形式的外部应用,以方便治疗不同的疾病。他们是勒帕、乌德瓦尔塔纳、乌帕那哈、阿比扬加、马拉哈拉等。不用在Panchavidha Kashaya Kalpana下定义面霜,我们可以将面霜的制备与Lepa或Malahara Kalpana联系起来。面霜就是那种油包水或水包油的乳剂。Durvadya Taila是阿育吠陀用于kachchu, Vicharchika和Pama的药用油,属于kustha Rogadhikar。
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引用次数: 0
A comparative clinical study to access the role of Basti and Virechana Karma followed by Rasayana in post menopausal Asthikshaya (Osteoporosis) 一项对比临床研究,探讨basi和Virechana Karma在绝经后骨质疏松症中的作用
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.12
D. S. Patil, S. Prashantha
Rajonivrutti condition manifests in the end phase of Jarawastha; but its Samprapti begins from the Sandhikala of Madhyamawastha and Jarawastha due to Vatavruddi in womens reaching Rajonivrutti. Postmenopausal Asthikshaya is a disabling disease, which renders women a bedridden life. Here 40 subjects diagnosed with postmenopausal Asthikshaya fulfilling the inclusion criteria were selected for the study and randomly categorized intp two groups as group A and group B each consisting of 20 subjects. Group A received Amapachana with Hinguvachadivati, Yastimadhu Siddha Ksheerabasti administered in Yoga Basti schedule followed by Tritiyatriphala Rasayana. Group B received Amapachana with Hinguvachadivati, Sadhyosnehapana with Amrita Ghrita, Sarvanga Abyanga with Murchita Tilataila followed by Sarvanga Swedana and Sneha Virechana was admistered with Eranda Taila followed by Tritiyatriphala Rasayana was given. Tritiya Triphala Rasayana selected for the present study by adapting all the general principles of prevention and management of Asthikshaya and as it is a well known Rasayana.
Rajonivrutti病症表现在贾拉瓦什邦末期;但是它的Samprapti开始于中央邦和贾拉瓦斯塔邦的Sandhikala,因为Vatavruddi在妇女中达到了Rajonivrutti。绝经后Asthikshaya是一种致残疾病,使妇女卧床不起。本研究选择40例符合入选标准的绝经后Asthikshaya患者,随机分为A组和B组,每组20例。A组接受Amapachana与Hinguvachadivati, Yastimadhu Siddha Ksheerabasti在Yoga Basti计划中进行,然后是tritiytriphala Rasayana。B组用阿玛帕查那加欣古瓦哈帝,Sadhyosnehapana加Amrita Ghrita, Sarvanga Abyanga加Murchita Tilataila后加Sarvanga Swedana, Sneha Virechana加Eranda Taila后加tritiytriphala Rasayana。Tritiya Triphala Rasayana是通过适应Asthikshaya预防和管理的所有一般原则而选择的,因为它是一个众所周知的Rasayana。
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引用次数: 1
Pharmaceutico analytical study of Ashwagandha Ghrita 印楝药材的药学分析研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.31
Amrita Raveendran, S. Rao, S. Vikram
Ashwagandha (Withania somnifera (L) Family - Solanaceae) known as Indian ginseng is an effective immunomodulator, aphrodisiac, sedative and adaptogen. Ashwagandha Ghrita is a ghee based Ayurvedic formulation which is available in the market, but Ashwagandha Ghrita containing Rasasindura and Tamra Bhasma along with Ashwagandha and Musta Churna is also mentioned in classical text which many of us are not aware of. As we all know that the action of Rasaushadhis are quick and require very less dose the one mentioned by Vagbhatacharya (author of Rasaratnasamuchaya) is the need of the hour for the immunomodulation. The current trend in applied instrumental medical research encourages good medical practice, clinical and research based drug analysis. The main aim of analytical study is to find out working standards for the formulations and safe use of therapeutics.
印度人参(Withania somnifera (L) Family - Solanaceae)被称为印度人参,是一种有效的免疫调节剂、春药、镇静剂和适应原。Ashwagandha Ghrita是一种基于阿育吠陀配方的酥油,在市场上可以买到,但Ashwagandha Ghrita含有Rasasindura和Tamra Bhasma,以及Ashwagandha和Musta Churna也在经典文本中提到,但我们很多人都不知道。我们都知道,Rasaushadhis的作用是迅速的,需要非常少的剂量,Vagbhatacharya (Rasaratnasamuchaya的作者)提到的是免疫调节需要的时间。目前应用仪器医学研究的趋势鼓励良好的医疗实践、临床和基于研究的药物分析。分析研究的主要目的是找出治疗制剂的配方和安全使用的工作标准。
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引用次数: 0
A study on the effectivness of Guggulu based Karaveera Ksharasutra in comparison with Apamarga Ksharasutra in the management of Shalyaja Nadivrana w.s.r. to Pilonidal Sinus 以古古鲁为基础的《卡拉维拉经》与阿帕玛伽经比较,探讨其治疗毛窦炎的有效性
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.2
Monisha C. J., Narmada M.G.
Shalyaja Nadivrana is of Agantuja Vranabedha. Nidana Panchaka is described in Sushruta Samhita Nidhana and Chikitsa Sthana. Presence of “Shalya” is hindering factor for healing. Management of Nadivrana includes Ksharasutra ligation. Pilonidal sinus is acquired sinus occurring in young hirsute men’s commonly seen at intergluteal cleft caused by hair penetrating the skin resulting in Pilonidal abscess which gradually forms into sinus with presence of “Hair” leading to wound discharge. It is one of the troublesome diseases which doesn’t respond to medical management till hair is evacuated. The current surgical procedures adopted have surgical risk and recurrence as well. Guggulu and Karaveera is abundantly available and can be preserved easily for long time. Hence can be used as substitute to the standard Ksharasutra. The present study “A study on the effectiveness of Guggulu based Karaveera Ksharasutra in comparison with Apamarga Ksharasutra in the management of Shalyaja Nadivrana w.s.r. to Pilonidal Sinus”was conducted in SJIIM hospital Bengaluru with 40 patients randomly allotted into 2 groups namely - Group A and Group B. Assessment was done based on subjective parameters like (pain, discharge) and objective parameters like (length of tract, tenderness). Observation was done before treatment and on every 7th day till tract is completely cut and healed. Assessment of Pain, discharge, length of tract and tenderness in Group-A showed 100%, 100%, 100% and 100% improvement and in Group-B showed 97.92%, 100%, 100% and 100% respectively. UCT in Group-A is 6.58% and Group-B is 9.15%. Overall results of group A and B is 100% and 99.5% respectively. Statistical analysis revealed that the effectiveness of Guggulu based Karaveera Ksharasutra in Shalyaja Nadivrana is as effective as Apamarga Ksharasutra w.s.r. to pilonidal sinus.
Shalyaja Nadivrana是Agantuja Vranabedha。在Sushruta Samhita Nidhana和Chikitsa Sthana中描述了Nidana Panchaka。“沙利亚”的存在是阻碍治疗的因素。中脉的管理包括枢椎结扎。毛毛窦是发生在年轻多毛男性的获得性窦,常见于臀间裂,由毛发穿透皮肤引起毛毛脓肿,毛毛脓肿逐渐形成窦,有“毛发”存在,导致伤口流出。它是一种棘手的疾病,直到头发被清除后才对医疗管理起作用。目前采用的手术方式存在手术风险和复发风险。Guggulu和Karaveera是丰富的,可以很容易地保存很长时间。因此可以用来代替标准的《经》。本研究是在班加罗尔SJIIM医院进行的“Guggulu - based Karaveera Ksharasutra与Apamarga Ksharasutra的疗效对比研究”,将40名患者随机分为两组,即A组和b组。根据主观参数(疼痛、分泌物)和客观参数(尿道长度、压痛)进行评估。治疗前观察,每7天观察一次,直到尿道完全切开愈合。a组疼痛、分泌物、尿路长度和压痛改善率分别为100%、100%、100%和100%,b组分别为97.92%、100%、100%和100%。a组的UCT为6.58%,b组为9.15%。A组和B组的总有效率分别为100%和99.5%。统计分析显示,以古古鲁为基础的卡拉维拉口服液在沙利亚纳迪芙拉纳的有效性与阿帕玛加口服液w.s.r.对脊髓窦的有效性相同。
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引用次数: 0
A clinical study to evaluate the efficacy of Murivenna application on Episiotomy Wound 评价Murivenna应用于会阴切口创面的临床研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.8
K. P, S. Patil
A surgically planned incision on the perineum and the posterior vaginal wall during the second stage of labor is called episiotomy (Perineotomy). It is in fact an inflicted second-degree perineal injury. It is the most common obstetric operation performed. This is done to enlarge the vaginal introitus to facilitate easy and safe delivery of the fetus and to minimize overstretching and rupture of the perineal muscles and fascia thus to reduce the stress and strain on the fetal head. This wound of episiotomy is associated with a delicate area of the female with immense pain and discomfort and seeks appropriate medical care and attention. If ignored, it may lead to puerperal wound infections and delayed healing that can interfere mother-infant interaction, lactation and prolonged hospital stay. Episiotomy wound care should be start immediately after suturing the wound in order to reduce pain and inflammation. The surgical wound of episiotomy can be considered as Sadyo Vrana. Different treatment modalities have been told in Ayurveda for Vrana Chikitsa. Drugs having Shodhana and Ropana qualities are essential for healing. In this research study total 30 patients were registered and treated in two groups, group A with application of Jatyadi Taila on episiotomy wound after Ushna Jala Parisheka as a standard control group and Group B with application of Murivenna after Ushna Jala Parisheka as a trial group. Encouraging results were observed in Murivenna. Study emerges that Murivenna possess better pain relieving and tenderness diminishing properties.
在分娩第二阶段在会阴和阴道后壁上进行手术计划的切口称为会阴切开术。实际上是会阴部二级损伤。这是最常见的产科手术。这样做是为了扩大阴道开口,以方便和安全地分娩胎儿,并尽量减少会阴肌肉和筋膜的过度拉伸和破裂,从而减少对胎儿头部的压力和紧张。这种外阴切开术的伤口与女性的脆弱区域有关,具有巨大的疼痛和不适,需要适当的医疗护理和关注。如果忽视,它可能导致产褥期伤口感染和愈合延迟,从而干扰母婴互动、哺乳和延长住院时间。会阴切开术创面护理应在创面缝合后立即开始,以减少疼痛和炎症。会阴切开术的手术伤口可以认为是sdiyo Vrana。阿育吠陀对Vrana Chikitsa有不同的治疗方法。具有Shodhana和Ropana性质的药物对治疗至关重要。本研究共登记30例患者,分为两组进行治疗,A组为标准对照组,使用Jatyadi Taila涂抹在Ushna Jatyadi Taila涂抹在Ushna Jala Parisheka术后外阴切口创面,B组为试验组。在穆里文纳观察到令人鼓舞的结果。研究表明,木纹草具有较好的镇痛和消痛性能。
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引用次数: 0
Pharmaceutico analytical study of Mukha Kanthikara Lepa and development of its new dosage form into Cream and Gel 枇杷的药学分析研究及新剂型乳膏和凝胶的研制
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.22
Amaresha Jeedi, S. Yadav, Surekha S. Medikeri
The need for cosmetics is seen from very ancient days; peoples were using variety of cosmetic products both for curative purpose as well as enhancing beauty. Mukhakantikara Lepa is a polyherbal formulation mentioned in Sharandhara Samhita in the form of Churna, which is extensively used to enhance skin complexion. In present time, the difficulty of portability, application, removal and shelf life of the Churna is a great challenge to Lepa form though being effective. Here arises a need for newer dosage form. Creams and gels are semisolid preparations which may be defined as topical products intended for application on skin or accessible mucous membrane to provide localised and sometimes systemic effects at the site of application. This dosage forms are more stable, easy to handle, easy to apply and remove. Hence, modification of Mukhakatikara Lepa into Cream and Gel can be a better idea to overcome the shortcoming of Lepa form.
对化妆品的需求从非常古老的时代就可以看到;人们使用各种各样的化妆品既用于治疗目的,也用于美容。Mukhakantikara Lepa是Sharandhara Samhita中以Churna形式提到的一种多草药配方,广泛用于改善皮肤肤色。目前,虽然乐巴剂型有效,但其便携性、应用、去除、保质期等方面的困难对乐巴剂型的发展是一个很大的挑战。这就产生了对新剂型的需要。面霜和凝胶是半固体制剂,可定义为局部产品,用于涂抹在皮肤或可触及的粘膜上,以在涂抹部位提供局部和有时是全身效果。这种剂型更稳定,易于操作,易于涂抹和去除。因此,将Mukhakatikara乐巴修改成乳霜和凝胶是一个更好的主意,可以克服乐巴形态的缺点。
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引用次数: 0
Pharmaceutical and Analytical Study of Ashwagandha Paak Ashwagandha Paak的药学和分析研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.35
Baban Rathod, Gangaprasad R. Asore, Kanchan Bhawarlal Suthar
Avaleha / Paak Kalpana is Upkalpana of Kwatha which is commonly prepared nowadays and useful in various disorders. Because of simple preparation method, better palatability and longer shelf life it is gaining popularity on a large scale. Ashwagandha Paak has been prepared as per reference of Bharat Bhaishajya Ratnakar. After preparation it has been studied for its quality and pharmaceutical parameters.
Avaleha / Paak Kalpana是Kwatha的Upkalpana,现在通常准备,对各种疾病都有用。由于其制作方法简单,适口性好,保质期长,正受到人们的广泛欢迎。Ashwagandha Paak是根据Bharat Bhaishajya Ratnakar的参考编写的。制备后对其进行了质量和药学参数的研究。
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引用次数: 0
Pharmaceutico-Analytical study of Karanjadi Taila and its conversion into cream 卡兰加迪草及其制乳膏的药学分析研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.34
Sachin S. Sheth, Gangaprasad R. Asore, Kiran Sudhakar Darade
Karanjadi Taila is medicated oil used in Ayurveda for Indralupta (Alopecia). Indralupta comes under Kshudra Roga which is characterized by loss of hair it can be correlated with Alopecia areata which is having chief complaint of hair loss on body especially on scalp. The aim of the present study is to do physic-chemical standards for the above Taila and its conversion into Karanjadi Taila cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Tailas or cream. In present article, we are trying to study analytical results of Karanjadi Taila w.s.r. to Karanjadi Taila cream.
Karanjadi Taila是阿育吠陀用于治疗因陀罗笈多(脱发)的药用油。因陀罗毗陀病属于虚陀罗伽病,其特征是脱发,它可能与斑秃有关斑秃是身体尤其是头皮上脱发的主要症状。本研究的目的是对上述泰拉及其转化为Karanjadi泰拉乳膏的理化标准进行研究。从药学的角度来看,这两种制剂与通常的泰拉或乳膏相比具有特殊的重要性。本文对卡兰加迪卡兰乳膏的分析结果进行了研究。
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引用次数: 0
A comparative clinical study to evaluate the effect of Indrayavadi Yoga and Bhoomyamalaki Choorna in the management of Asrigdara w.s.r. to Puberty Menorrhagia 评价因陀罗雅梵瑜伽和博玛玛拉基瑜伽治疗青春期月经过多的临床对照研究
Pub Date : 2020-10-25 DOI: 10.21760/jaims.5.5.4
Patil Ashwini Shrimant, P. Rawal, Sunita Shiraguppi, Shrishail. S. Pujeri
A normal menstruation denotes a healthy state of female reproductive system. If the menstrual bleeding is abnormally excessive, prolonged and is associated with pain, it indicates some pathology. The abnormal menstrual cycle not only disturbs the general health, it also disturbs routine work schedule of the woman and her entire family. There is no direct reference of Puberty menorrhagia in classics. Puberty menorrhagia is defined as excessive bleeding occurring between menarche to 19 years of age. Anovulatory bleeding with irregular shedding of endometrium is the cause for puberty Menorrhagia which can be effectively tackled with the help of herbal drugs which contains hemostatic action. Asrigdara mainly due to vitiation of Vata and Pitta Doshas, hence the treatment should be based on use of drugs which are having predominance of Kashayarasa and Pitta-Vatashamaka properties and Stambhan action. Thus selected drugs are Indrayavadi Yoga and Bhoomyamalaki Choorna possess Vata-Pitta Shamaka and Raktastambhaka. This research work is comparative clinical study. 40 patients presenting with Pratyatma Lakshana of Asrigdara were randomly selected and divided into 2 groups of 20 patients each. Group A were given Indrayavadi Yoga and group B were given Bhoomyamalaki Choorna for a period of 2 menstrual cycle and two follow up during treatment and one follow up after treatment. After the completion of clinical trial, it was found that Bhoomyamalaki Choorna which was group B is more effective than group A. The overall effect in group A and Group B, both the groups shown excellent response, but when comparing all the parameters Bhoomyamalaki Choorna shown more significant response than Indrayavadi Yoga. Trial drug is a better remedy for Asrigdara. It has no side effect, cost effective.
月经正常表明女性生殖系统处于健康状态。如果月经出血异常多、时间长,并伴有疼痛,则说明有某种病理。不正常的月经周期不仅扰乱了一般的健康,也扰乱了妇女及其整个家庭的日常工作安排。经书中没有关于青春期月经过多的直接记载。青春期月经过多被定义为发生在初潮至19岁之间的大量出血。无排卵性出血与不规则脱落的子宫内膜是青春期月经过多的原因,可以有效地解决与草药的帮助下,其中含有止血作用。Asrigdara主要是由于Vata和Pitta Doshas的破坏,因此治疗应该基于使用具有Kashayarasa和Pitta- vatashamaka特性和Stambhan作用的药物。因此,选择的药物是因陀罗雅梵瑜伽和Bhoomyamalaki Choorna拥有Vata-Pitta Shamaka和Raktastambhaka。本研究为临床比较研究。随机选择40例出现阿斯rigdara的pratatma Lakshana患者,分为2组,每组20例。A组给予因陀罗雅梵瑜伽,B组给予bomyamalaki Choorna,疗程2个月经周期,治疗中随访2次,治疗后随访1次。临床试验完成后,发现B组的bomyamalaki Choorna比A组更有效,A组和B组的整体效果都很好,但在比较所有参数时,bomyamalaki Choorna的反应比因陀罗瓦迪瑜伽更显著。试验药物对Asrigdara来说是更好的治疗方法。无副作用,性价比高。
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引用次数: 0
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Journal of Ayurveda and Integrated Medical Sciences (JAIMS)
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