Journal of Clinical Periodontology最新文献_第5页

The efficacy of reconstructive therapy in the surgical management of peri-implantitis: A 3-year follow-up of a randomized clinical trial 重建疗法在种植体周围炎手术治疗中的疗效：随机临床试验的三年随访。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-17 DOI: 10.1111/jcpe.14049

Stefan Renvert, Jean-Louis Giovannoli, Sven Rinke

Aim

To assess whether guided bone regeneration (GBR) treatment of peri-implantitis-related bony defects could improve healing compared to open flap debridement (OFD) at 36 months.

Materials and Methods

In a multi-centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), mucosal recession (MREC) and patient-reported outcomes (PROs) were evaluated at 36 months.

Results

Fifty individuals attended a supportive peri-implant therapy program and completed the 36-month follow-up. GBR treatment resulted in an RDF of 2.13 ± 1.26 mm compared to 1.64 ± 1.54 mm following OFD (p = .18). No difference was found in PPD, BOP, SUP, REC or PROs between the groups. Successful treatment (no additional bone loss, PPD ≤ 5 mm, no BOP and no SUP) was achieved in 46.2% in TG and 20% in CG (p = .053). Treatment results obtained at 12 months were generally maintained up to 36 months. No significant changes were noticed between 12 and 36 months.

Conclusions

At 36 months, treatment results obtained at 1 year were sustained following both GBR and OFD in patients attending supportive peri-implant therapy. GBR resulted in more RDF and higher composite treatment success rate than OFD (ClinicalTrials.gov Identifier [NCT02375750]).

目的：与开放皮瓣清创术（OFD）相比，评估种植体周围炎相关骨缺损的引导骨再生（GBR）治疗是否能在36个月后改善愈合情况：在一项多中心随机临床试验中，32 人接受了开放皮瓣清创术（对照组 [CG]），34 人接受了 GBR 治疗（试验组 [TG]）。在 36 个月时对放射学缺损填充（RDF）、探诊袋深度（PPD）、探诊出血（BOP）、化脓（SUP）、粘膜衰退（MREC）和患者报告结果（PROs）进行评估：结果：50 人参加了支持性种植体周围治疗项目，并完成了 36 个月的随访。GBR 治疗后的 RDF 为 2.13 ± 1.26 mm，而 OFD 治疗后的 RDF 为 1.64 ± 1.54 mm（p = .18）。两组之间在 PPD、BOP、SUP、REC 或 PRO 方面没有差异。治疗成功率（无额外骨质流失、PPD ≤ 5 毫米、无 BOP 和无 SUP）：TG 组为 46.2%，CG 组为 20%（p = .053）。12 个月时取得的治疗效果一般都能保持到 36 个月。结论：36个月后，接受GBR和OFD支持性种植体周围治疗的患者在1年后获得的治疗效果得以保持。与 OFD 相比，GBR 的 RDF 更多，综合治疗成功率更高（ClinicalTrials.gov Identifier [NCT02375750]）。

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引用次数: 0

Correction to “Selective BET inhibitor RVX-208 ameliorates periodontal inflammation and bone loss” 更正为 "选择性 BET 抑制剂 RVX-208 可改善牙周炎症和骨质流失"。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-17 DOI: 10.1111/jcpe.14044

Sun, M, Clayton, N, Alam, S, Asmussen, N, Wong, A, Kim, JH, Luong, G, Mokhtari, S, Pellei, D, Carrico, CK, Schwartz, Z, Boyan, BD, Giannobile, WV, Sahingur, SE, Lin, Z. J Clin Periodontol. 2023 Dec; 50(12): 1658–1669. https://doi.org/10.1111/jcpe.13887. Epub 2023 Oct 19.

In materials and methods 2.1 (page 1660), the following sentence should have been as follows:

“THP-1 cells were cultured in Roswell Park Memorial Institute (RPMI) 1640 medium (Life Technologies) with 10% HI-FBS, 0.05 mM 2-mercaptoethanol and 1% PS.”

In materials and methods 2.2 (page 1660), the following sentence should have been as follows:

“For THP-1 cells, the cells were pre-treated using 50 ng/mL PMA overnight to initiate the cell attachment and differentiation.”

The experimental results and corresponding conclusions mentioned in the paper remain unaffected. We sincerely apologize for this error.

Sun, M, Clayton, N, Alam, S, Asmussen, N, Wong, A, Kim, JH, Luong, G, Mokhtari, S, Pellei, D, Carrico, CK, Schwartz, Z, Boyan, BD, Giannobile, WV, Sahingur, SE, Lin, Z. J Clin Periodontol. 2023 年 12 月；50（12）：1658–1669. https://doi.org/10.1111/jcpe.13887.Epub 2023 Oct 19.在材料与方法 2.1（第 1660 页）中，以下句子应为："THP-1 细胞在罗斯威尔公园纪念研究所（RPMI）1640 培养基（Life Technologies）中培养，培养基中添加 10% HI-FBS、0.05 mM 2-巯基乙醇和 1% PS。2（第 1660 页）中，以下句子应为："对于 THP-1 细胞，使用 50 ng/mL PMA 预处理细胞一夜，以启动细胞附着和分化。"论文中提到的实验结果和相应结论不受影响。我们对这一错误表示诚挚的歉意。

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引用次数: 0

Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context 牙周炎的孟德尔随机研究：了解应用背景下的优势和自然限制。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-16 DOI: 10.1111/jcpe.14029

Simon Haworth, Nicholas J. Timpson, Kimon Divaris

Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that with care, this does not necessarily prevent valuable deployment of the approach. We argue that clarity of presentation as well as careful assessment of specific analytical conditions is a fundamental part of all MR analyses. To that end, awareness of its limitations should also guide the design of MR investigations and the presentation of results rather than rule out its use altogether. Notably, considerations similar to those known to be important in conventional epidemiological settings apply to MR. While MR studies are valuable in their contrast to other study limitations, the application of this technique must be carefully cross-examined. Specific considerations include possible confounders, recruitment strategy and phenotypic measurement and differential analysis properties across studies. In the case of periodontal research, current MR applications are limited by the available evidence base for genetic contributions to periodontitis; however, this sets a specific scene for the strategic use of MR and shines light on a need for greater research emphasis on the genetics of the condition and intermediaries. This article provides a perspective on the uses and inherent limitations of MR studies and the importance of adhering to basic epidemiological principles when designing them.

孟德尔随机化（Mendelian randomization，MR）是一种灵活的分析工具，已被广泛应用于加强观察性流行病学的因果推断，目前在包括牙周病研究在内的许多领域正受到越来越多的关注。对遗传变异法得出的结果的解释基于一系列假设，在某些情况下，这些假设可能不切实际或难以忠实地实现。不过，我们认为，只要小心谨慎，这并不一定会妨碍该方法的宝贵应用。我们认为，清晰的表述以及对具体分析条件的仔细评估是所有 MR 分析的基本组成部分。为此，对其局限性的认识也应指导磁共振研究的设计和结果的呈现，而不是完全排除其使用。值得注意的是，与传统流行病学环境中已知的重要因素类似的考虑因素也适用于磁共振。虽然磁共振研究在对比其他研究局限性方面很有价值，但在应用这种技术时必须仔细斟酌。具体考虑因素包括可能的混杂因素、招募策略和表型测量，以及不同研究之间的差异分析特性。就牙周研究而言，目前磁共振技术的应用受限于牙周炎遗传因素的现有证据基础；不过，这为战略性使用磁共振技术提供了一个特定场景，并揭示了对牙周炎遗传学和中间体进行更多研究的必要性。本文从一个角度阐述了磁共振研究的用途和固有局限性，以及在设计磁共振研究时遵守基本流行病学原则的重要性。

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引用次数: 0

Non-surgical retreatment versus papillary preservation flap surgery for residual pockets: A randomized controlled trial with clinical and patient-reported outcomes 治疗残余牙周袋的非手术再治疗与乳头保留瓣手术：临床和患者报告结果的随机对照试验。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-16 DOI: 10.1111/jcpe.14047

Luigi Barbato, Desirée Noce, Maria Di Martino, Walter Castelluzzo, Folco Spoleti, Cosimo Rupe, Michele Nieri, Francesco Cairo

Aim

To compare the efficacy of non-surgical re-instrumentation (NSR) and papillary preservation flap (PPF) surgery at single-rooted teeth with residual pockets.

Materials and Methods

Patients with at least a residual pocket depth (PD ≥ 5 mm) after Steps I and II were enrolled and randomly assigned to receive NSR or PPF surgery. The primary outcome was PD reduction, and secondary outcomes were clinical attachment level (CAL) change and patient-reported outcome measures (PROMs). Outcome variables were measured at baseline, 3 and 6 months. The examiner was blinded. Statistical analysis, one site for each patient, included descriptive statistics and analysis of covariance.

Results

Forty-six participants were enrolled, and one patient dropped out in the PPF group. After 6 months, both treatments resulted in significant PD reduction (1.3 ± 1.2 mm, p = .009 NSR; 2.0 ± 0.7 mm, p < .001 PPF) and CAL gain (1.0 ± 2.4 mm, p = .031 NSR; 1.4 ± 0.8 mm, p < .001 PPF). PD reduction between groups was not statistically significant (diff: 0.6 mm; 95% confidence interval [CI] [−0.3 to 1.5]; p = .167). Pocket closure was 61% NSR versus 86% PPF (p = .091). Smoking was associated with less PD reduction of almost 1 mm in both treatments. Treatment time was longer for PPF surgery, but PROMs and post-operative pain were similar between groups.

Conclusions

Both NSR and PPF reduced PD without significant difference between treatments at 6 months. PPF surgery may offer faster PD reduction, but smoking habits reduce treatment efficacy.

目的：比较对有残余袋的单根牙进行非手术再装置（NSR）和乳头保留瓣（PPF）手术的疗效：对经过步骤 I 和步骤 II 后至少有一个残余袋深度（PD ≥ 5 mm）的患者进行登记，并随机分配其接受 NSR 或 PPF 手术。主要结果是PD减少，次要结果是临床附着水平（CAL）变化和患者报告结果测量（PROMs）。结果变量在基线、3个月和6个月时进行测量。检查者为盲人。统计分析包括描述性统计和协方差分析：结果：46 名患者参加了治疗，PPF 组有一名患者退出。6 个月后，两种治疗方法都能显著减少 PD（1.3 ± 1.2 mm，p = .009 NSR；2.0 ± 0.7 mm，p 结论：NSR 和 PPF 都能减少 PD：NSR和PPF都能减少PD，但6个月后治疗效果无明显差异。PPF手术可更快地减少PD，但吸烟习惯会降低治疗效果。

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引用次数: 0

Association between volatile organic compounds exposure and periodontitis: A representative cross-sectional study 挥发性有机化合物暴露与牙周炎之间的关系：一项具有代表性的横断面研究。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-14 DOI: 10.1111/jcpe.14041

Haitao Dong, Xueting Wang, Ning Xiao, Xin Yang, Xin Zhang, Piye Niu, Tian Chen

Aim

Periodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross-sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based on data from the National Health and Nutrition Examination Survey (NHANES, 2011–2014).

Materials and Methods

We analysed data on blood VOC levels, periodontitis and related covariates from 2772 participants of the NHANES. The association between the blood VOCs and periodontitis was analysed using weighted logistic regression analysis, the restricted cubic spline (RCS) model and the weighted quantile sum (WQS) regression model. Interaction tests and mediation analysis were also conducted.

Results

After adjusting for covariates, for each natural constant-fold increase in 1,4-dichlorobenzene, the odds of having periodontitis increased by 16% (odds ratio = 1.16; 95% confidence interval: 1.08–1.24, p < .001). WQS regression model indicated that 1,4-dichlorobenzene contributed the most to the association between VOC co-exposure and periodontitis. Mediation analysis further revealed that total bilirubin levels mediated the association between 1,4-dichlorobenzene and the prevalence of periodontitis, accounting for 4.32%. In addition, the positive association between o-xylene and periodontitis was more pronounced in the <65-year-old group.

Conclusions

This study has provided relatively little evidence to demonstrate a specific link between VOCs and periodontitis. Nonetheless, exposure to VOCs remains a non-negligible public health concern, and further research is required to investigate the association and potential mechanisms of action between VOCs and periodontitis.

目的：牙周炎是最常见的口腔疾病之一，也是成年人牙齿脱落的主要原因。环境污染与牙周炎的发病率密切相关。然而，很少有研究关注挥发性有机化合物（VOC）与牙周炎之间的关系。这项横断面研究旨在根据美国国家健康与营养调查（NHANES，2011-2014 年）的数据，研究暴露于挥发性有机化合物是否与牙周炎有关：我们分析了2772名NHANES参与者的血液中挥发性有机化合物水平、牙周炎和相关协变量的数据。我们使用加权逻辑回归分析、受限立方样条（RCS）模型和加权量化和（WQS）回归模型分析了血液中挥发性有机化合物与牙周炎之间的关系。此外，还进行了交互检验和中介分析：结果：在对协变量进行调整后，1,4-二氯苯的浓度每增加一个自然常数倍，患牙周炎的几率就会增加 16%（几率比 = 1.16；95% 置信区间：1.08-1.24，P 结论：该研究为牙周炎的发生提供了相对较少的证据：本研究提供的证据相对较少，无法证明挥发性有机化合物与牙周炎之间存在特定联系。然而，暴露于挥发性有机化合物仍然是一个不可忽视的公共健康问题，需要进一步研究挥发性有机化合物与牙周炎之间的关联和潜在作用机制。

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引用次数: 0

Using SWATH-MS to identify new molecular biomarkers in gingival crevicular fluid for detecting periodontitis and its response to treatment 利用 SWATH-MS 在牙龈沟液中鉴定新的分子生物标记物，以检测牙周炎及其对治疗的反应。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-10 DOI: 10.1111/jcpe.14037

T. Blanco-Pintos, A. Regueira-Iglesias, M. Relvas, M. Alonso-Sampedro, M. P. Chantada-Vázquez, C. Balsa-Castro, I. Tomás

Aim

To identify new biomarkers to detect untreated and treated periodontitis in gingival crevicular fluid (GCF) using sequential window acquisition of all theoretical mass spectra (SWATH-MS).

Materials and Methods

GCF samples were collected from 44 periodontally healthy subjects and 40 with periodontitis (Stages III–IV). In the latter, 25 improved clinically 2 months after treatment. Samples were analysed using SWATH-MS, and proteins were identified by the UniProt human-specific database. The diagnostic capability of the proteins was determined with generalized additive models to distinguish the three clinical conditions.

Results

In the untreated periodontitis vs. periodontal health modelling, five proteins showed excellent or good bias-corrected (bc)-sensitivity/bc-specificity values of >80%. These were GAPDH, ZG16B, carbonic anhydrase 1, plasma protease inhibitor C1 and haemoglobin subunit beta. GAPDH with MMP-9, MMP-8, zinc-α-2-glycoprotein and neutrophil gelatinase-associated lipocalin and ZG16B with cornulin provided increased bc-sensitivity/bc-specificity of >95%. For distinguishing treated periodontitis vs. periodontal health, most of these proteins and their combinations revealed a predictive ability similar to previous modelling. No model obtained relevant results to differentiate between periodontitis conditions.

Conclusions

New single and dual GCF protein biomarkers showed outstanding results in discriminating untreated and treated periodontitis from periodontal health. Periodontitis conditions were indistinguishable. Future research must validate these findings.

目的：利用所有理论质谱的顺序窗口采集（SWATH-MS）技术，确定检测牙龈缝隙液（GCF）中未治疗和已治疗牙周炎的新生物标记物：采集了 44 名牙周健康者和 40 名牙周炎患者（III-IV 期）的 GCF 样本。后者中有 25 人在治疗 2 个月后临床症状有所改善。使用 SWATH-MS 对样本进行分析，并通过 UniProt 人类特异性数据库对蛋白质进行鉴定。利用广义加性模型确定了蛋白质的诊断能力，以区分三种临床状况：结果：在未经治疗的牙周炎与牙周健康模型中，有五种蛋白质的灵敏度/特异度偏差校正（bc）值大于80%，显示出极佳或良好的灵敏度/特异度偏差校正（bc）值。它们是 GAPDH、ZG16B、碳酸酐酶 1、血浆蛋白酶抑制剂 C1 和血红蛋白亚基 beta。GAPDH与MMP-9、MMP-8、锌-α-2-糖蛋白和中性粒细胞明胶酶相关脂褐质以及ZG16B与玉米蛋白的bc敏感性/bc特异性均大于95%。在区分治疗过的牙周炎与牙周健康方面，这些蛋白质及其组合的预测能力与以前的模型相似。在区分牙周炎条件方面，没有任何模型能获得相关结果：结论：新的单一和双重 GCF 蛋白生物标志物在区分未经治疗和已治疗的牙周炎与牙周健康方面表现突出。牙周炎的情况无法区分。未来的研究必须验证这些发现。

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引用次数: 0

Association between masticatory function and depression in older adults: Results from NHANES 2009 to 2018 老年人咀嚼功能与抑郁之间的关系：2009 年至 2018 年美国国家健康调查（NHANES）结果。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-10 DOI: 10.1111/jcpe.14046

Xindi Wei, Xiaomeng Zhang, Xiao Zhang, Ruiying Chen, Maurizio S. Tonetti, Junyu Shi, Hongchang Lai

Aim

Depression is prevalent among older adults. Although the number of missing teeth is considered to be associated with depression, the relationship between masticatory function, which is usually indicated by functional tooth units (FTUs), and depression in older adults remains unclear.

Materials and Methods

This study used data from the National Health and Nutrition Examination Survey (NHANES) 2009–2018. The number of FTUs was defined as pairs of opposing natural and artificial teeth. Depression was accessed using the Patient Health Questionnaire (PHQ-9), and participants who scored ≥10 on PHQ-9 were diagnosed with depression. Logistic regression analyses, propensity score matching (PSM) analyses and subgroup analyses were conducted to assess the association between FTU and depression.

Results

The analysis included 5764 individuals over 60 years. An association between FTU and the risk of depression among older adults was detected (odds ratio [OR] = 0.951, 95% confidence interval [CI] 0.915–0.989), suggesting protective roles of more FTUs. Significant increase in the risk of depression in 0 ≤ FTUs ≤ 3 was observed compared with 10 ≤ FTUs ≤ 12 (OR = 1.819, 95% CI 1.157–2.858). However, no significant increase in the risk of depression in 4 ≤ FTUs ≤ 9 was found. After PSM, significant increase in the risk of depression in 0 ≤ FTUs ≤ 3 was still detected compared with 4 ≤ FTUs ≤ 12 (OR = 1.484, 95% CI 1.030–2.136). Subgroup analyses demonstrated consistent results in all subgroups, except for individuals aged 76–80 and drinking regularly.

Conclusions

The findings suggested the association between impaired masticatory function and the risk of depression among older adults. Longitudinal studies are needed to elucidate the role of masticatory function impairment in the development of depression further.

目的：抑郁症在老年人中很普遍。虽然缺牙数量被认为与抑郁有关，但通常以功能性牙齿单位（FTU）表示的咀嚼功能与老年人抑郁之间的关系仍不清楚：本研究使用了 2009-2018 年美国国家健康与营养调查（NHANES）的数据。FTU 的数量定义为对立的天然牙和人工牙。通过患者健康问卷（PHQ-9）了解抑郁情况，PHQ-9得分≥10分的参与者被诊断为抑郁症患者。研究人员进行了逻辑回归分析、倾向得分匹配（PSM）分析和亚组分析，以评估 FTU 与抑郁症之间的关系：分析对象包括 5764 名 60 岁以上的老年人。研究发现，FTU 与老年人患抑郁症的风险之间存在关联（几率比 [OR] = 0.951，95% 置信区间 [CI] 0.915-0.989），这表明更多的 FTU 具有保护作用。与 10 ≤ FTU ≤ 12 相比，0 ≤ FTU ≤ 3 患抑郁症的风险显著增加（OR = 1.819，95% 置信区间 [CI] 1.157-2.858）。然而，4 ≤ FTU ≤ 9 的抑郁风险没有明显增加。在 PSM 后，与 4 ≤ FTU ≤ 12 相比，0 ≤ FTU ≤ 3 的抑郁风险仍有明显增加（OR = 1.484，95% CI 1.030-2.136）。亚组分析表明，除了年龄在76-80岁之间且经常饮酒的人之外，所有亚组的结果都是一致的：研究结果表明，咀嚼功能受损与老年人患抑郁症的风险有关。要进一步阐明咀嚼功能受损在抑郁症发病中的作用，还需要进行纵向研究。

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引用次数: 0

A nomogram-based predictive model for tooth survival in Chinese patients with periodontitis: An 11-year retrospective cohort study 基于提名图的中国牙周炎患者牙齿存活率预测模型：一项为期 11 年的回顾性队列研究。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-10 DOI: 10.1111/jcpe.14027

Shuwen Shi, Yang Meng, Jian Jiao, Dong Shi, Xianghui Feng, Huanxin Meng

Aim

To develop a nomogram-based predictive model of tooth survival by comprehensively analysing clinical and radiographic risk factors of tooth loss (TL).

Materials and Methods

In this study, 3447 teeth of 131 subjects who underwent non-surgical periodontal treatment were examined retrospectively within a mean follow-up period of 11.6 years. The association of risk factors including clinical and radiographic parameters with TL was assessed using univariate and multivariate Cox regression analyses. A nomogram-based predictive model was developed, and its validation and discriminatory ability were analysed.

Results

In all, 313 teeth were lost in 94 patients in this study (overall tooth loss [OTL] 9.08%; 0.21 teeth/patient/year). Male, heavy smoking, molar teeth, probing depth (PD), attachment loss (AL), tooth mobility and radiographic bone loss were significantly associated with TL (p < .05). A gradient effect of tooth mobility on TL increased from degree I to III versus none (p < .0001). The area under the curve (AUC) of the model was 0.865. Calibration curve and decision curve analysis demonstrated good performance and high net benefit, respectively.

Conclusions

Adopting a specific nomogram could facilitate the prediction of tooth survival and the development of tailored treatment plans in Chinese patients with advanced periodontitis.

目的：通过全面分析牙齿脱落（TL）的临床和放射学风险因素，建立基于提名图的牙齿存活率预测模型：本研究对 131 名接受过非手术牙周治疗的受试者的 3447 颗牙齿进行了回顾性检查，平均随访时间为 11.6 年。使用单变量和多变量 Cox 回归分析评估了包括临床和放射学参数在内的风险因素与 TL 的关系。研究还建立了一个基于提名图的预测模型，并对其验证和判别能力进行了分析：本研究中共有 94 名患者的 313 颗牙齿脱落（总牙齿脱落率 [OTL] 9.08%；0.21 颗/患者/年）。男性、大量吸烟、磨牙、探诊深度 (PD)、附着丧失 (AL)、牙齿移动性和放射骨丧失与 TL 显著相关（p 结论：采用特定的提名图可以帮助确定牙齿缺失的程度：采用特定的提名图有助于预测中国晚期牙周炎患者的牙齿存活率并制定有针对性的治疗方案。

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引用次数: 0

Association of the Life's Essential 8 cardiovascular health score with periodontitis among US adults 美国成年人生活必备 8 项心血管健康评分与牙周炎的关系。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-04 DOI: 10.1111/jcpe.14042

Lang Liang, Chia-Yu Chen, Izzuddin M. Aris

Aim

To investigate whether cardiovascular health (CVH) is associated with periodontitis.

Materials and Methods

We used data from the 2009 to 2014 National Health and Nutrition Examination Survey. We quantified CVH using Life's Essential 8, which includes four health behaviours (diet, smoking, physical activity and sleep) and four health factors (body mass index, blood cholesterol, glucose and pressure). We categorized scores as low (0–49), moderate (50–79) and high (80–100). We calculated subscores of health behaviours and factors and categorized them as low, moderate and high. We used logistic regression to assess the association of CVH with periodontitis, adjusting for age, gender, race/ethnicity, education, poverty index, marital status and health insurance. We computed odds ratios (ORs) and 95% confidence intervals (CIs).

Results

This study included 9296 adults ≥30 years old. Multivariable-adjusted models showed that subjects with moderate (OR, 0.62; 95% CI: 0.52–0.74) or high (OR, 0.43; 95% CI: 0.33–0.57) CVH had significantly lower odds of periodontitis compared to those with low CVH. These results were consistent in the health behaviours model, but the estimates in the health factors model were not significant.

Conclusions

Improving CVH may help prevent periodontitis. Longitudinal studies are needed to confirm our findings.

目的：研究心血管健康（CVH）是否与牙周炎有关：我们使用了 2009 年至 2014 年全国健康与营养调查的数据。我们使用 "生活必备 8 要素 "对心血管健康进行量化，其中包括四种健康行为（饮食、吸烟、体育锻炼和睡眠）和四种健康因素（体重指数、血胆固醇、血糖和血压）。我们将得分分为低分（0-49 分）、中分（50-79 分）和高分（80-100 分）。我们计算了健康行为和因素的子分数，并将其分为低、中和高。我们使用逻辑回归评估了 CVH 与牙周炎的关系，并对年龄、性别、种族/民族、教育程度、贫困指数、婚姻状况和医疗保险进行了调整。我们计算了几率比（ORs）和 95% 的置信区间（CIs）：本研究共纳入 9296 名年龄≥30 岁的成年人。多变量调整模型显示，与低 CVH 受试者相比，中度（OR，0.62；95% CI：0.52-0.74）或高度（OR，0.43；95% CI：0.33-0.57）CVH 受试者患牙周炎的几率明显较低。这些结果在健康行为模型中是一致的，但在健康因素模型中的估计值并不显著：结论：改善CVH有助于预防牙周炎。需要进行纵向研究来证实我们的发现。

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引用次数: 0

Supportive periodontal care with or without subgingival instrumentation: Microbiological results of a 2-year randomized clinical trial 使用或不使用龈下器械的支持性牙周护理：为期两年的随机临床试验的微生物学结果。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-02 DOI: 10.1111/jcpe.14038

P. D. M. Angst, U. Van der Velden, C. Susin, S. C. Gomes

Aim

To compare the subgingival microbiota of patients receiving supportive periodontal care (SPC) with and without subgingival instrumentation, over 2 years.

Materials and Methods

This study was a randomized clinical trial that included 62 participants (50.97 ± 9.26 years old; 40 females) who completed non-surgical periodontal therapy. Participants were randomly assigned to receive oral prophylaxis with oral hygiene instructions alone (test) or in combination with subgingival instrumentation (control) during SPC. Pooled subgingival biofilm samples were obtained from four sites per patient at SPC baseline and at 3, 6, 12, 18, and 24 months. Real-time polymerase chain reaction was used for absolute quantification of Eubacteria and the target bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. Data were analysed using generalized estimating equations, taking into consideration the clustering of observations within individuals.

Results

No significant differences were found between the experimental groups regarding the mean counts of Eubacteria and target bacteria, as well as the periodontal parameters at the sampled sites. Although significant variability in bacterial counts was present during SPC, all counts after 2 years were not statistically different from those at baseline. Bacterial counts were associated with the presence of plaque, bleeding on probing, mean probing depth ≥3 mm, and follow-up period.

Conclusions

SPC with or without subgingival instrumentation can result in comparable subgingival microbiological outcomes. Clinical trial registration: clinicaltrials.gov: NCT01598155 (https://clinicaltrials.gov/study/NCT01598155?intr=supragingival%20control&rank=4#study-record-dates).

目的：比较接受支持性牙周护理（SPC）和不接受龈下器械治疗的患者在两年内的龈下微生物群：本研究是一项随机临床试验，包括 62 名完成非手术牙周治疗的参与者（50.97 ± 9.26 岁；40 名女性）。参与者被随机分配到在 SPC 期间单独接受口腔卫生指导的口腔预防治疗（试验）或结合龈下器械治疗的口腔预防治疗（对照）。在 SPC 基线期、3、6、12、18 和 24 个月时，从每位患者的四个部位采集龈下生物膜样本。实时聚合酶链反应用于绝对定量龈上真菌和目标细菌牙龈卟啉单胞菌、连翘单胞菌和牙髓震颤素。数据采用广义估计方程进行分析，并考虑了个体内观察结果的聚类：结果：在取样部位，实验组与实验组之间在抑菌和目标细菌的平均数量以及牙周参数方面没有发现明显差异。虽然在 SPC 期间细菌数量存在明显差异，但两年后的所有细菌数量与基线时的细菌数量在统计学上没有差异。细菌计数与牙菌斑的存在、探诊出血、平均探诊深度≥3毫米和随访时间有关：临床试验注册：clinicaltrials.gov：临床试验注册：clinicaltrials.gov：NCT01598155 (https://clinicaltrials.gov/study/NCT01598155?intr=supragingival%20control&rank=4#study-record-dates)。

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引用次数: 0