Muqiao Yu, Yilin Luo, Bolin Li, Lingqiao Xu, Xingmei Yang, Yi Man
Aim
This study aimed to evaluate the efficiency of and discrepancies between planned and final implant positions using dynamic computer-assisted implant surgery (d-CAIS) and autonomous robotic computer-assisted implant surgery (r-CAIS) in clinical practice.
Materials and Methods
The study included 83 patients, who received 135 implants between December 2022 and March 2024 (r-CAIS group: 43 patients with 71 implants; d-CAIS group: 40 patients with 64 implants). Cone-beam computed tomography scans taken before and after surgery assessed linear and angular deviations between the groups in both 2D and 3D spaces. The duration of surgery was also analysed.
Results
The angular deviation between d-CAIS and r-CAIS was 3.61° ± 1.65° versus 1.62° ± 0.93° (p < 0.001), the platform deviation was 1.12 ± 0.51 mm versus 0.50 ± 0.19 mm (p < 0.001) and the apex deviation was 1.36 ± 0.57 mm versus 0.58 ± 0.21 mm (p < 0.001). The d-CAIS group experienced significantly longer drilling and implant placement times compared to the r-CAIS group (10.6 ± 3.8 vs. 8.3 ± 3.4 min, p < 0.01), while preparation time showed no statistical difference between the groups (7.2 ± 3.3 vs. 6.2 ± 2.7 min, p > 0.05).
Conclusions
The robotic system demonstrated higher accuracy and efficiency of implant placement than the dynamic navigation system in partially edentulous patients.
目的本研究旨在评估临床实践中使用动态计算机辅助种植手术（d‐CAIS）和自主机器人计算机辅助种植手术（r‐CAIS）的效率和计划种植位置与最终种植位置之间的差异。材料和方法该研究纳入83例患者，在2022年12月至2024年3月期间接受了135个种植体(r‐CAIS组：43例患者，71个种植体；d‐CAIS组：40例患者，共植入64颗植入物)。手术前后进行锥形束计算机断层扫描，评估两组患者在二维和三维空间中的线性和角度偏差。并对手术时间进行分析。结果d‐CAIS与r‐CAIS的角偏差分别为3.61°±1.65°和1.62°±0.93°(p <；0.001)，平台偏差分别为1.12±0.51 mm和0.50±0.19 mm (p <；分别为1.36±0.57 mm和0.58±0.21 mm (p <；0.001)。与r - CAIS组相比，d - CAIS组钻孔和种植体放置时间明显更长(10.6±3.8 vs 8.3±3.4 min, p <；0.01)，而准备时间组间差异无统计学意义(7.2±3.3 vs. 6.2±2.7 min, p >；0.05)。结论在部分无牙患者中，机器人系统比动态导航系统具有更高的种植精度和效率。
{"title":"A Comparative Prospective Study on the Accuracy and Efficiency of Autonomous Robotic System Versus Dynamic Navigation System in Dental Implant Placement","authors":"Muqiao Yu, Yilin Luo, Bolin Li, Lingqiao Xu, Xingmei Yang, Yi Man","doi":"10.1111/jcpe.14091","DOIUrl":"10.1111/jcpe.14091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the efficiency of and discrepancies between planned and final implant positions using dynamic computer-assisted implant surgery (d-CAIS) and autonomous robotic computer-assisted implant surgery (r-CAIS) in clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study included 83 patients, who received 135 implants between December 2022 and March 2024 (r-CAIS group: 43 patients with 71 implants; d-CAIS group: 40 patients with 64 implants). Cone-beam computed tomography scans taken before and after surgery assessed linear and angular deviations between the groups in both 2D and 3D spaces. The duration of surgery was also analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The angular deviation between d-CAIS and r-CAIS was 3.61° ± 1.65° versus 1.62° ± 0.93° (<i>p</i> < 0.001), the platform deviation was 1.12 ± 0.51 mm versus 0.50 ± 0.19 mm (<i>p</i> < 0.001) and the apex deviation was 1.36 ± 0.57 mm versus 0.58 ± 0.21 mm (<i>p</i> < 0.001). The d-CAIS group experienced significantly longer drilling and implant placement times compared to the r-CAIS group (10.6 ± 3.8 vs. 8.3 ± 3.4 min, <i>p</i> < 0.01), while preparation time showed no statistical difference between the groups (7.2 ± 3.3 vs. 6.2 ± 2.7 min, <i>p</i> > 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The robotic system demonstrated higher accuracy and efficiency of implant placement than the dynamic navigation system in partially edentulous patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"280-288"},"PeriodicalIF":5.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chuanyuan Mao, Weijun Yu, Lu Lin, Ruhan Yang, Shucheng Hu, Guanglong Li, Yuting Gu, Min Jin, Eryi Lu
Aim: To establish a reproducible experimental animal model for systemic lupus erythematosus (SLE)-associated periodontitis (PD), investigate the effects of SLE on PD and assess the therapeutic potential of alpha-ketoglutarate (αKG) for SLE-PD treatment.
Materials and methods: An SLE-PD murine model was established via ligature-induced PD in MRL-lpr strain, with MRL/MpJ strain as a non-SLE control. The periodontal state was assessed using micro-CT, real-time PCR, histology, immunofluorescence and flow cytometry assays. αKG levels were analysed, and a thermoresponsive gel was designed as a periodontal dimethyl (DM)-αKG delivery system. αKG levels were analysed in gingival crevicular fluid (GCF) of PD patients with or without SLE.
Results: SLE significantly increased the periodontal inflammation and bone resorption in the SLE-PD model. αKG levels in GCF were lower in PD patients with SLE than in PD patients without SLE. Decreased αKG levels in the gingiva and macrophage M1/M2 imbalance were observed in SLE-PD mice. However, DM-αKG thermoresponsive gel effectively alleviated the periodontal inflammation, bone resorption and macrophage M1/M2 imbalance in SLE-PD mice.
Conclusions: Our study established, for the first time, a novel SLE-PD murine model and revealed that SLE increases the severity of PD in vivo. Our findings highlight the therapeutic potential of αKG for SLE-associated PD.
{"title":"Alpha-Ketoglutarate Alleviates Systemic Lupus Erythematosus-Associated Periodontitis in a Novel Murine Model.","authors":"Chuanyuan Mao, Weijun Yu, Lu Lin, Ruhan Yang, Shucheng Hu, Guanglong Li, Yuting Gu, Min Jin, Eryi Lu","doi":"10.1111/jcpe.14080","DOIUrl":"https://doi.org/10.1111/jcpe.14080","url":null,"abstract":"<p><strong>Aim: </strong>To establish a reproducible experimental animal model for systemic lupus erythematosus (SLE)-associated periodontitis (PD), investigate the effects of SLE on PD and assess the therapeutic potential of alpha-ketoglutarate (αKG) for SLE-PD treatment.</p><p><strong>Materials and methods: </strong>An SLE-PD murine model was established via ligature-induced PD in MRL-lpr strain, with MRL/MpJ strain as a non-SLE control. The periodontal state was assessed using micro-CT, real-time PCR, histology, immunofluorescence and flow cytometry assays. αKG levels were analysed, and a thermoresponsive gel was designed as a periodontal dimethyl (DM)-αKG delivery system. αKG levels were analysed in gingival crevicular fluid (GCF) of PD patients with or without SLE.</p><p><strong>Results: </strong>SLE significantly increased the periodontal inflammation and bone resorption in the SLE-PD model. αKG levels in GCF were lower in PD patients with SLE than in PD patients without SLE. Decreased αKG levels in the gingiva and macrophage M1/M2 imbalance were observed in SLE-PD mice. However, DM-αKG thermoresponsive gel effectively alleviated the periodontal inflammation, bone resorption and macrophage M1/M2 imbalance in SLE-PD mice.</p><p><strong>Conclusions: </strong>Our study established, for the first time, a novel SLE-PD murine model and revealed that SLE increases the severity of PD in vivo. Our findings highlight the therapeutic potential of αKG for SLE-associated PD.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EXPRESSION OF CONCERN: Role of Cytokines in Development of Pre-Eclampsia Associated with Periodontal Disease-Cohort Study.","authors":"","doi":"10.1111/jcpe.14088","DOIUrl":"https://doi.org/10.1111/jcpe.14088","url":null,"abstract":"","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoe Kit Chee, Frank Abbas, Arie Jan van Winkelhoff, Geerten Has Tjakkes, Hla Myint Htoon, Huihua Li, Yvonne de Waal, Arjan Vissink, Chaminda Jayampath Seneviratne
AimTo assess the glycaemic status of Asian patients in a tertiary care dental setting and develop a risk model for undiagnosed diabetes mellitus (DM).Material and MethodsA total of 1074 participants completed a diabetes risk test questionnaire, full‐mouth periodontal examination and a point‐of‐care HbA1c finger‐prick blood test. Univariable logistic regression was performed to assess the effect of potential factors to predict DM, with confirmed diabetes as the outcome. Subsequently, multivariable logistic regression analysis with stepwise variable selection was employed to develop the final models for predicting DM.ResultsSixty‐five (6.1%) and 83 (7.7%) of the 1074 participants were medically confirmed with T2DM and prediabetes, respectively. The ‘best’ predictive risk model for DM included body mass index (BMI), family history of diabetes, smoking and a diagnosis of Stage III/IV or severe periodontitis with an area under the curve (AUC) of 0.717 (95% confidence interval, CI [0.689–0.744]) and 0.721 (95% CI [0.693–0.748]), respectively. Including the oral health measure marginally increased the AUC.ConclusionsDental patients clinically diagnosed with advanced periodontitis in combination with high BMI, positive family history of DM and smoking are potentially at high risk for DM and should be screened for DM and referred for medical confirmation and management.
{"title":"Identifying Undiagnosed Diabetes and Prediabetes in the Dental Setting in an Asian Population—A Clinical Risk Model","authors":"Hoe Kit Chee, Frank Abbas, Arie Jan van Winkelhoff, Geerten Has Tjakkes, Hla Myint Htoon, Huihua Li, Yvonne de Waal, Arjan Vissink, Chaminda Jayampath Seneviratne","doi":"10.1111/jcpe.14090","DOIUrl":"https://doi.org/10.1111/jcpe.14090","url":null,"abstract":"AimTo assess the glycaemic status of Asian patients in a tertiary care dental setting and develop a risk model for undiagnosed diabetes mellitus (DM).Material and MethodsA total of 1074 participants completed a diabetes risk test questionnaire, full‐mouth periodontal examination and a point‐of‐care HbA1c finger‐prick blood test. Univariable logistic regression was performed to assess the effect of potential factors to predict DM, with confirmed diabetes as the outcome. Subsequently, multivariable logistic regression analysis with stepwise variable selection was employed to develop the final models for predicting DM.ResultsSixty‐five (6.1%) and 83 (7.7%) of the 1074 participants were medically confirmed with T2DM and prediabetes, respectively. The ‘best’ predictive risk model for DM included body mass index (BMI), family history of diabetes, smoking and a diagnosis of Stage III/IV or severe periodontitis with an area under the curve (AUC) of 0.717 (95% confidence interval, CI [0.689–0.744]) and 0.721 (95% CI [0.693–0.748]), respectively. Including the oral health measure marginally increased the AUC.ConclusionsDental patients clinically diagnosed with advanced periodontitis in combination with high BMI, positive family history of DM and smoking are potentially at high risk for DM and should be screened for DM and referred for medical confirmation and management.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Luisa Mizgier, Gino Nardocci, Valeria Ramírez, María José Bendek, Marcela Hernández, Carolina Rojas, David Herrera, Alpdogan Kantarci, Matthew W. Kemp, Sebastián E. Illanes, Alejandra Chaparro
Aim
To characterize the gingival crevicular fluid (GCF) and plasma extracellular vesicles (EVs) and explore their proteomic cargo in healthy pregnant women compared to those with gestational diabetes mellitus (GDM) and periodontitis.
Methods
One-hundred and four pregnant women were recruited at 24–30 gestation weeks. GDM was diagnosed by an oral glucose tolerance test. GCF and plasma samples were obtained to isolate EVs and characterized by nanoparticle tracking, immunoassays, electron microscopy and mass spectrometry.
Results
Of the recruits,17.3% women were healthy, 50% had periodontitis and 32.7% had both GDM and periodontitis. Probing depth, clinical attachment loss and bleeding on probing were more severe in GDM and periodontitis pregnancies (p < 0.0001). Additionally, this group showed an increase concentration of total, small and large GCF-EVs (p = 0.0015, p = 0.0011 and p = 0.0008, respectively), with decreased expression of CD9, CD81 and CD81/CD63 ratio (p = 0.0461, p = 0.0164 and p = 0.0005, respectively). No differences were observed in plasmatic EVs concentration or markers expression. Proteomic analysis of GCF-EVs showed peptides of both host and bacterial origin. Gene ontology analysis revealed that proteins of GCF-EVs participate in immune inflammatory responses, glucose metabolism and insulin response mechanisms.
Conclusion
GCF-EVs were increased in both GDM and periodontitis, and their proteomic cargo suggest their involvement in immune inflammatory response, glucose metabolism and insulin pathways during pregnancy.
{"title":"Proteomic Insights Into Gingival Crevicular Extracellular Vesicles in Periodontitis and Gestational Diabetes: An Exploratory Study","authors":"María Luisa Mizgier, Gino Nardocci, Valeria Ramírez, María José Bendek, Marcela Hernández, Carolina Rojas, David Herrera, Alpdogan Kantarci, Matthew W. Kemp, Sebastián E. Illanes, Alejandra Chaparro","doi":"10.1111/jcpe.14083","DOIUrl":"10.1111/jcpe.14083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To characterize the gingival crevicular fluid (GCF) and plasma extracellular vesicles (EVs) and explore their proteomic cargo in healthy pregnant women compared to those with gestational diabetes mellitus (GDM) and periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One-hundred and four pregnant women were recruited at 24–30 gestation weeks. GDM was diagnosed by an oral glucose tolerance test. GCF and plasma samples were obtained to isolate EVs and characterized by nanoparticle tracking, immunoassays, electron microscopy and mass spectrometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the recruits,17.3% women were healthy, 50% had periodontitis and 32.7% had both GDM and periodontitis. Probing depth, clinical attachment loss and bleeding on probing were more severe in GDM and periodontitis pregnancies (<i>p</i> < 0.0001). Additionally, this group showed an increase concentration of total, small and large GCF-EVs (<i>p =</i> 0.0015, <i>p =</i> 0.0011 and <i>p =</i> 0.0008, respectively), with decreased expression of CD9, CD81 and CD81/CD63 ratio (<i>p =</i> 0.0461, <i>p =</i> 0.0164 and <i>p =</i> 0.0005, respectively). No differences were observed in plasmatic EVs concentration or markers expression. Proteomic analysis of GCF-EVs showed peptides of both host and bacterial origin. Gene ontology analysis revealed that proteins of GCF-EVs participate in immune inflammatory responses, glucose metabolism and insulin response mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GCF-EVs were increased in both GDM and periodontitis, and their proteomic cargo suggest their involvement in immune inflammatory response, glucose metabolism and insulin pathways during pregnancy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"225-236"},"PeriodicalIF":5.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nils Werner, Iris Frasheri, Katrin Heck, Carla Scalia, Vinay Pitchika, Burkhard Summer, Christina Ern, Richard Heym, Falk Schwendicke, Caspar Victor Bumm, Matthias Folwaczny
Aim
To analyse whether some selected inflammatory biomarkers collected from venous blood and gingival crevicular fluid (GCF) were associated with the outcome of non-surgical periodontal therapy.
Materials and Methods
Two-hundred and nine patients affected by periodontitis were enrolled in the study, who had undergone steps I and II therapy as well as a non-surgical re-instrumentation (NSRI) of periodontal pockets after 6 months. Serum (SE), plasma (PL) and GCF samples were quantitatively analysed for the following inflammatory biomarkers: active matrix metalloproteinase-8 (aMMP-8), prostaglandin E2 (PGE2) and surfactant protein D (SP-D). Therapy outcomes were evaluated using a ‘treat-to-target’ endpoint (T2T) at the patient level, defined as ≤ 4 sites with pocket depth ≥ 5 mm.
Results
Patients presented with 23 ± 6 teeth (mean ± SD) at baseline. After steps I and II therapy, 41.6% of the patients reached T2T and after NSRI 47.4%. Univariate analysis identified a potential association between high levels of PL-SP-D and more favourable treatment outcomes. Multivariate binary logistic regression adjusted for sex, mean baseline probing depth, diabetes and current smoking status confirmed an independent relationship between baseline PL-SP-D and the T2T after steps I and II therapy (aOR 0.432, p = 0.011), implying that a higher level PL-SP-D at baseline is associated with a > 50% reduced risk of failing T2T. However, no such association was found for PL-SP-D and NSRI.
Conclusion
Higher baseline PL-SP-D levels might be associated with more favourable treatment outcomes after steps I and II therapy. This may be due to its role in the regulation of neutrophil function. However, further investigation is required to confirm this hypothesis. If proven, PL-SP-D could play a role as a biomarker for identifying individuals who respond differentially to primary therapy.
目的分析从静脉血和牙龈缝隙液（GCF）中采集的某些特定炎症生物标志物是否与牙周非手术疗法的结果有关。材料与方法研究纳入了 290 名牙周炎患者，他们接受了第一步和第二步疗法，并在 6 个月后对牙周袋进行了非手术再刺激（NSRI）。对血清 (SE)、血浆 (PL) 和 GCF 样品进行了以下炎症生物标记物的定量分析：活性基质金属蛋白酶-8 (aMMP-8)、前列腺素 E2 (PGE2) 和表面活性蛋白 D (SP-D)。治疗结果采用患者水平的 "治疗到目标 "终点（T2T）进行评估，"治疗到目标 "终点的定义是：牙槽深度≥ 5 毫米的部位≤ 4 个。经过第一步和第二步治疗后，41.6%的患者达到了T2T，经过NSRI治疗后，47.4%的患者达到了T2T。单变量分析发现，高水平的 PL-SP-D 与更有利的治疗结果之间存在潜在联系。多变量二元逻辑回归调整了性别、平均基线探查深度、糖尿病和当前吸烟状况，证实基线 PL-SP-D 与步骤 I 和步骤 II 治疗后的 T2T 之间存在独立关系（aOR 0.432，p = 0.011），这意味着基线 PL-SP-D 水平越高，T2T 失败的风险就会降低 50%。结论较高的基线 PL-SP-D 水平可能与 I 步和 II 步治疗后更有利的治疗结果有关。这可能是由于 PL-SP-D 在中性粒细胞功能调节中的作用。然而，要证实这一假设还需要进一步的研究。如果得到证实，PL-SP-D 可作为一种生物标志物，用于识别对初治有不同反应的个体。
{"title":"A Study Into Systemic and Oral Levels of Proinflammatory Biomarkers Associated With Endpoints After Active Non-Surgical Periodontal Therapy","authors":"Nils Werner, Iris Frasheri, Katrin Heck, Carla Scalia, Vinay Pitchika, Burkhard Summer, Christina Ern, Richard Heym, Falk Schwendicke, Caspar Victor Bumm, Matthias Folwaczny","doi":"10.1111/jcpe.14089","DOIUrl":"10.1111/jcpe.14089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyse whether some selected inflammatory biomarkers collected from venous blood and gingival crevicular fluid (GCF) were associated with the outcome of non-surgical periodontal therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two-hundred and nine patients affected by periodontitis were enrolled in the study, who had undergone steps I and II therapy as well as a non-surgical re-instrumentation (NSRI) of periodontal pockets after 6 months. Serum (SE), plasma (PL) and GCF samples were quantitatively analysed for the following inflammatory biomarkers: active matrix metalloproteinase-8 (aMMP-8), prostaglandin E2 (PGE2) and surfactant protein D (SP-D). Therapy outcomes were evaluated using a ‘treat-to-target’ endpoint (T2T) at the patient level, defined as ≤ 4 sites with pocket depth ≥ 5 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients presented with 23 ± 6 teeth (mean ± SD) at baseline. After steps I and II therapy, 41.6% of the patients reached T2T and after NSRI 47.4%. Univariate analysis identified a potential association between high levels of PL-SP-D and more favourable treatment outcomes. Multivariate binary logistic regression adjusted for sex, mean baseline probing depth, diabetes and current smoking status confirmed an independent relationship between baseline PL-SP-D and the T2T after steps I and II therapy (aOR 0.432, <i>p</i> = 0.011), implying that a higher level PL-SP-D at baseline is associated with a > 50% reduced risk of failing T2T. However, no such association was found for PL-SP-D and NSRI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher baseline PL-SP-D levels might be associated with more favourable treatment outcomes after steps I and II therapy. This may be due to its role in the regulation of neutrophil function. However, further investigation is required to confirm this hypothesis. If proven, PL-SP-D could play a role as a biomarker for identifying individuals who respond differentially to primary therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"188-198"},"PeriodicalIF":5.8,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AimPeriodontal disease (PD) screening models based on a self‐reported questionnaire were previously established and externally validated. The aim of the present study is to explore whether the screening models could be modified to improve prediction performance; this methodology is called ‘updating’.MethodsUpdating the models for ‘total’ and ‘severe’ PD was performed using two datasets. One dataset from a previous study (n = 155) was used to explore the updating, and a second (n = 187, built for the current study) was used to validate whether updating improved performance. Updating was based on different statistical approaches, including model recalibration and revision. Discrimination and calibration were assessed after updating.ResultsFor ‘total’ PD, the update based on model revision improved its performance. However, still low AUCs were found: 0.64 (0.56–0.73) and 0.61 (0.53–0.69) with corresponding O:E ratios 1.00 (0.80–1.23) and 0.92 (0.75–1.13) in the update and validation cohorts, respectively. For ‘severe’ PD, performance of the original model without update performed still the best; AUCs were 0.72 (0.61–0.83) and 0.75 (0.66–0.84) in the update and validation cohorts, respectively, with corresponding O:E ratios 0.60 (0.38–0.84) and 0.62 (0.42–0.87).ConclusionsThe updating methodology did not further improve the performance of the original ‘severe’ PD screening model; it performed satisfactorily in the medical care setting. Despite updating attempts, the screening model for ‘total’ PD remained sub‐optimal. Screening for ‘severe’ PD can now be implemented in the medical care setting.
{"title":"Attempts to Modify Periodontal Screening Models Based on a Self‐Reported Oral Health Questionnaire in the Medical Care Setting","authors":"N. Nijland, N. Su, V. E. A. Gerdes, B. G. Loos","doi":"10.1111/jcpe.14069","DOIUrl":"https://doi.org/10.1111/jcpe.14069","url":null,"abstract":"AimPeriodontal disease (PD) screening models based on a self‐reported questionnaire were previously established and externally validated. The aim of the present study is to explore whether the screening models could be modified to improve prediction performance; this methodology is called ‘updating’.MethodsUpdating the models for ‘total’ and ‘severe’ PD was performed using two datasets. One dataset from a previous study (<jats:italic>n</jats:italic> = 155) was used to explore the updating, and a second (<jats:italic>n</jats:italic> = 187, built for the current study) was used to validate whether updating improved performance. Updating was based on different statistical approaches, including model recalibration and revision. Discrimination and calibration were assessed after updating.ResultsFor ‘total’ PD, the update based on model revision improved its performance. However, still low AUCs were found: 0.64 (0.56–0.73) and 0.61 (0.53–0.69) with corresponding O:E ratios 1.00 (0.80–1.23) and 0.92 (0.75–1.13) in the update and validation cohorts, respectively. For ‘severe’ PD, performance of the original model without update performed still the best; AUCs were 0.72 (0.61–0.83) and 0.75 (0.66–0.84) in the update and validation cohorts, respectively, with corresponding O:E ratios 0.60 (0.38–0.84) and 0.62 (0.42–0.87).ConclusionsThe updating methodology did not further improve the performance of the original ‘severe’ PD screening model; it performed satisfactorily in the medical care setting. Despite updating attempts, the screening model for ‘total’ PD remained sub‐optimal. Screening for ‘severe’ PD can now be implemented in the medical care setting.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To investigate the effect of periodontitis on the long-term changes of the cardio-ankle vascular index (CAVI).
Materials and methods: A 10-year retrospective cohort study of 3842 Thai participants (range 25-76 years) with normal CAVI at the study initiation was undertaken. Full-mouth periodontal examination was performed by calibrated periodontists, and the extent and severity of periodontitis were determined at 5-year intervals. Serial CAVI measurements were used to examine the incidence of high CAVI (≥ 9.0) and changes in CAVI over time (ΔCAVI).
Results: Participants with a higher extent or severity of periodontitis were found to have a significantly higher mean ΔCAVI. The incidence of high CAVI was also observed to be higher in those with periodontitis compared to those without it. The adjusted risk ratios for developing high CAVI were 1.309 and 1.513 for localized and generalized periodontitis, respectively. Participants with severe periodontitis had a 37% higher likelihood of developing CAVI ≥ 9.0 compared to individuals with no/mild periodontitis. This risk was consistent with a significant change in ΔCAVI of 0.054-0.140.
Conclusions: Periodontitis, both in terms of extent and severity, was found to have a significant dose-dependent effect on the risk of developing high CAVI over a 10-year period, suggesting a causal relationship between these two parameters.
{"title":"Periodontitis Is Associated With Arterial Stiffness as Measured by Serial Cardio-Ankle Vascular Index (CAVI): A 10-Year Cohort Study.","authors":"Bantita Kanpittaya, Attawood Lertpimonchai, Sanutm Mongkornkarn, Lakshman Samaranayake, Nisakorn Thongmung, Thosaphol Limpijankit, Orawan Charatkulangkun","doi":"10.1111/jcpe.14086","DOIUrl":"https://doi.org/10.1111/jcpe.14086","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of periodontitis on the long-term changes of the cardio-ankle vascular index (CAVI).</p><p><strong>Materials and methods: </strong>A 10-year retrospective cohort study of 3842 Thai participants (range 25-76 years) with normal CAVI at the study initiation was undertaken. Full-mouth periodontal examination was performed by calibrated periodontists, and the extent and severity of periodontitis were determined at 5-year intervals. Serial CAVI measurements were used to examine the incidence of high CAVI (≥ 9.0) and changes in CAVI over time (ΔCAVI).</p><p><strong>Results: </strong>Participants with a higher extent or severity of periodontitis were found to have a significantly higher mean ΔCAVI. The incidence of high CAVI was also observed to be higher in those with periodontitis compared to those without it. The adjusted risk ratios for developing high CAVI were 1.309 and 1.513 for localized and generalized periodontitis, respectively. Participants with severe periodontitis had a 37% higher likelihood of developing CAVI ≥ 9.0 compared to individuals with no/mild periodontitis. This risk was consistent with a significant change in ΔCAVI of 0.054-0.140.</p><p><strong>Conclusions: </strong>Periodontitis, both in terms of extent and severity, was found to have a significant dose-dependent effect on the risk of developing high CAVI over a 10-year period, suggesting a causal relationship between these two parameters.</p>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the hypoxic changes in periodontal tissues resulting from smoking and periodontitis by assessing levels of hypoxia-inducible factors (HIF-1α, HIF-2α, HIF-3α) and vascular endothelial growth factor (VEGF) in gingival crevicular fluid (GCF).
Materials and Methods
The study comprised 22 periodontally healthy non-smokers (Group H), 22 periodontally healthy smokers (Group HS), 22 non-smokers with periodontitis (Group P) and 22 smokers with periodontitis (Group PS). Clinical periodontal parameters were documented, and GCF samples were collected and analysed using enzyme-linked immunosorbent assay (ELISA).
Results
Significantly elevated levels of HIF-1α, HIF-3α and VEGF were observed in Groups HS, P and PS compared to Group H (p < 0.05). Moreover, higher HIF-2α levels were detected in the Groups HS and P compared to Group H (p < 0.05). Significant correlations were detected between all evaluated hypoxia biomarkers in the Group P (p < 0.05) except HIF-2α and HIF-3α. However, in the PS group, significant correlation appeared only between HIF-1α and HIF-2α (p < 0.05).
Conclusion
Our findings indicate that smoking and periodontitis induce comparable hypoxic effects in periodontal tissues, as evidenced by the evaluated biomarkers. Further research is warranted to gain a deeper understanding of the mechanisms underlying hypoxia in periodontal tissues.
{"title":"Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis","authors":"Bejna Bozyel, Özlem Doğan, Serenay Elgün, Burcu Özdemir","doi":"10.1111/jcpe.14087","DOIUrl":"10.1111/jcpe.14087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the hypoxic changes in periodontal tissues resulting from smoking and periodontitis by assessing levels of hypoxia-inducible factors (HIF-1α, HIF-2α, HIF-3α) and vascular endothelial growth factor (VEGF) in gingival crevicular fluid (GCF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study comprised 22 periodontally healthy non-smokers (Group H), 22 periodontally healthy smokers (Group HS), 22 non-smokers with periodontitis (Group P) and 22 smokers with periodontitis (Group PS). Clinical periodontal parameters were documented, and GCF samples were collected and analysed using enzyme-linked immunosorbent assay (ELISA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significantly elevated levels of HIF-1α, HIF-3α and VEGF were observed in Groups HS, P and PS compared to Group H (<i>p</i> < 0.05). Moreover, higher HIF-2α levels were detected in the Groups HS and P compared to Group H (<i>p</i> < 0.05). Significant correlations were detected between all evaluated hypoxia biomarkers in the Group P (<i>p</i> < 0.05) except HIF-2α and HIF-3α. However, in the PS group, significant correlation appeared only between HIF-1α and HIF-2α (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings indicate that smoking and periodontitis induce comparable hypoxic effects in periodontal tissues, as evidenced by the evaluated biomarkers. Further research is warranted to gain a deeper understanding of the mechanisms underlying hypoxia in periodontal tissues.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"249-257"},"PeriodicalIF":5.8,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingfei Wei, Yuanyuan Sun, Dedong Yu, Herman Pieterse, Daniel Wismeijer, Yuelian Liu, Yiqun Wu
Aim
This first randomized controlled trial in humans aimed to assess the efficacy and safety of low-dosage Escherichia coli-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2)-incorporated biomimetic calcium phosphate coating-functionalized β-TCP (ErhBMP-2/BioCaP/β-TCP) as a novel bone substitute using the tooth-extraction-socket-healing model.
Materials and Methods
Forty patients requiring dental implants after single-root tooth extraction were enrolled in this study and randomly assigned into three groups: ErhBMP-2/BioCaP/β-TCP (N = 15), β-TCP (N = 15) and natural healing (N = 10). New bone volume density from histomorphometric analyses was evaluated 6 weeks post-operatively as the primary outcome, and other histomorphometric analyses, alveolar bone and soft-tissue changes were the secondary outcomes. Safety parameters included adverse events, soft-tissue healing, oral health impact profile, serum BMP-2 concentrations and other laboratory tests.
Results
The findings revealed a significant increase in new bone volume density in patients treated with ErhBMP-2/BioCaP/β-TCP compared to those receiving β-TCP alone. The required bone augmentation procedures during implant placement surgery in the ErhBMP-2/BioCaP/β-TCP group were significantly less than in the natural healing group. There were no significant differences in safety parameters among the three groups.
Conclusion
This clinical trial primarily proved the safety and efficacy of ErhBMP-2/BioCaP/β-TCP as a promising bone substitute.
{"title":"The Clinical Efficacy and Safety of ErhBMP-2/BioCaP/β-TCP as a Novel Bone Substitute Using the Tooth-Extraction-Socket-Healing Model: A Proof-of-Concept Randomized Controlled Trial","authors":"Lingfei Wei, Yuanyuan Sun, Dedong Yu, Herman Pieterse, Daniel Wismeijer, Yuelian Liu, Yiqun Wu","doi":"10.1111/jcpe.14084","DOIUrl":"10.1111/jcpe.14084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This first randomized controlled trial in humans aimed to assess the efficacy and safety of low-dosage <i>Escherichia coli</i>-derived recombinant human bone morphogenetic protein 2 (ErhBMP-2)-incorporated biomimetic calcium phosphate coating-functionalized β-TCP (ErhBMP-2/BioCaP/β-TCP) as a novel bone substitute using the tooth-extraction-socket-healing model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty patients requiring dental implants after single-root tooth extraction were enrolled in this study and randomly assigned into three groups: ErhBMP-2/BioCaP/β-TCP (<i>N</i> = 15), β-TCP (<i>N</i> = 15) and natural healing (<i>N</i> = 10). New bone volume density from histomorphometric analyses was evaluated 6 weeks post-operatively as the primary outcome, and other histomorphometric analyses, alveolar bone and soft-tissue changes were the secondary outcomes. Safety parameters included adverse events, soft-tissue healing, oral health impact profile, serum BMP-2 concentrations and other laboratory tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings revealed a significant increase in new bone volume density in patients treated with ErhBMP-2/BioCaP/β-TCP compared to those receiving β-TCP alone. The required bone augmentation procedures during implant placement surgery in the ErhBMP-2/BioCaP/β-TCP group were significantly less than in the natural healing group. There were no significant differences in safety parameters among the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This clinical trial primarily proved the safety and efficacy of ErhBMP-2/BioCaP/β-TCP as a promising bone substitute.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 2","pages":"299-309"},"PeriodicalIF":5.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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