Journal of Clinical Periodontology最新文献_第6页

Contrast-Enhanced Micro-CT Imaging of Murine Mandibles: A Multi-Method Approach for Simultaneous Hard and Soft Tissue Analysis 小鼠下颌骨的对比度增强显微 CT 成像：多种方法同时分析硬组织和软组织

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-03 DOI: 10.1111/jcpe.14077

Torben Hildebrand, Yolanda Humphris, Håvard Jostein Haugen, Liebert Parreiras Nogueira

Aim

To develop and evaluate a novel multi-method micro-computed tomography (μCT) imaging protocol for enhanced visualization of both hard and soft tissues in murine mandibles, addressing the limitations of traditional imaging techniques in dental research.

Materials and Methods

We employed a contrast-enhanced (CE) μCT imaging technique using Lugol's iodine as a contrast agent to visualize the intricate structures of murine mandibles. The protocol involved the combination of conventional μCT imaging as well as CE-μCT, including decalcification with EDTA, allowing for simultaneous assessment of hard and soft tissues. The method is compared with standard imaging modalities, and the ability to visualize detailed anatomical features is discussed.

Results

The CE-μCT imaging technique provided superior visualization of murine mandibular structures, including dental pulp, periodontal ligaments and the surrounding soft tissues, along with conventional μCT imaging of alveolar bone and teeth. This method revealed detailed anatomical features with high specificity and contrast, surpassing traditional imaging approaches.

Conclusion

Our findings demonstrate the potential of CE-μCT imaging with Lugol's iodine as a powerful tool for dental research. This technique offers a comprehensive view of the murine mandible, facilitating advanced studies in tissue engineering, dental pathology and the development of dental materials.

目的：针对牙科研究中传统成像技术的局限性，开发并评估一种新型多方法微型计算机断层扫描（μCT）成像方案，以增强对小鼠下颌骨软硬组织的观察：我们采用了一种造影剂增强型（CE）μCT成像技术，使用鲁戈尔碘作为造影剂来观察小鼠下颌骨的复杂结构。该方法结合了传统的μCT成像和CE-μCT成像，包括用乙二胺四乙酸脱钙，可同时评估硬组织和软组织。该方法与标准成像模式进行了比较，并讨论了观察详细解剖特征的能力：结果：与牙槽骨和牙齿的传统μCT成像技术相比，CE-μCT成像技术能更好地观察小鼠下颌骨结构，包括牙髓、牙周韧带和周围软组织。这种方法以高特异性和高对比度显示了详细的解剖特征，超越了传统的成像方法：我们的研究结果表明，使用鲁戈尔碘的 CE-μCT 成像技术是牙科研究的有力工具。这项技术提供了小鼠下颌骨的全面视图，有助于组织工程、牙科病理学和牙科材料开发方面的高级研究。

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引用次数: 0

Periodontitis and Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis. 牙周炎与口腔健康相关的生活质量：系统回顾与元分析》。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-29 DOI: 10.1111/jcpe.14074

Catiusse Crestani Del' Agnese, Caroline Schöffer, Karla Zanini Kantorski, Fabricio Batistin Zanatta, Cristiano Susin, Raquel Pippi Antoniazzi

Aim: To investigate the association between periodontitis and oral health-related quality of life (OHRQoL) in adults, and to compare OHRQoL across different severities of the disease.

Materials and methods: Searches were conducted in five electronic databases up to December 2023. Observational studies that provided a clear definition of periodontitis and used validated measures of OHRQoL were included. Meta-analyses were performed both overall and based on factors that could explain heterogeneity between studies.

Results: Sixty studies comprising 14,851 individuals were included in the review. Meta-analyses showed that periodontitis was associated with impaired OHRQoL: any OHRQoL instruments (n = 33 studies; SMD: 0.75, 95% CI: 0.53-0.93), solely using the OHIP-14 (n = 26 studies; MD: 5.14, 95% CI: 3.64-6.64), and risk assessment (n = 9 studies; adjusted RR: 1.42, 95% CI: 1.12-1.78). Stages III-IV periodontitis had a greater impact than Stages I-II periodontitis. Subgroup and meta-regression analyses indicated smaller effect size estimates for individuals with comorbidities.

Conclusions: Periodontitis negatively impacts OHRQoL, with a positive score-response relationship found between periodontitis severity and poorer OHRQoL. However, the magnitude of this association appears to be diminished in individuals with comorbidities.

目的：研究成人牙周炎与口腔健康相关生活质量（OHRQoL）之间的关系，并比较不同严重程度的牙周炎患者的口腔健康相关生活质量：对截至 2023 年 12 月的五个电子数据库进行了检索。纳入了对牙周炎有明确定义并使用有效的 OHRQoL 测量方法的观察性研究。对研究的总体情况以及可解释研究间异质性的因素进行了元分析：综述共纳入了 60 项研究，涉及 14 851 人。Meta分析表明，牙周炎与OHRQoL受损有关：任何OHRQoL工具（n = 33项研究；SMD：0.75，95% CI：0.53-0.93），仅使用OHIP-14（n = 26项研究；MD：5.14，95% CI：3.64-6.64），以及风险评估（n = 9项研究；调整RR：1.42，95% CI：1.12-1.78）。III-IV 期牙周炎比 I-II 期牙周炎的影响更大。分组和元回归分析表明，合并症患者的效应大小估计值较小：结论：牙周炎对 OHRQoL 有负面影响，牙周炎严重程度与较差的 OHRQoL 之间存在正的分数-反应关系。结论：牙周炎对 OHRQoL 有负面影响，牙周炎严重程度与 OHRQoL 较差之间存在正向的分数-反应关系，但在有合并症的患者中，这种关系的程度似乎有所降低。

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引用次数: 0

Perceptions, Attitudes and Needs of Periodontitis Patients: A Qualitative Systematic Review 牙周炎患者的认知、态度和需求：定性系统回顾

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-27 DOI: 10.1111/jcpe.14058

Camila Pinheiro Furquim, Lina J. Suárez, Renata Tavares, Belén Retamal-Valdes, Murilo Fernando Neuppmann Feres, Magda Feres

Aim

Patient-reported outcomes (PROs) hold significant potential in guiding clinical decision making, yet their utilization in periodontal trials has been limited. This systematic review aimed to critically synthesize and analyse qualitative studies that evaluated the knowledge and impact of periodontitis and its treatment on patients' lives, as well as their motivations, expectations and experiences in seeking treatment.

Materials and Methods

Six databases were searched up to March 2024 for qualitative studies on periodontitis patients. Studies were quality-assessed using the JBI Critical Appraisal and ConQual tools. Two authors independently extracted the findings, with discrepancies resolved by a third reviewer.

Results

Thirteen studies from 2006 to 2023 across four continents, involving 215 participants, identified five themes related to periodontitis: (i) knowledge about periodontitis and its treatment; (ii) impact of periodontitis on patients' lives; (iii) motivation and treatment expectations; (iv) obstacles to treatment; and (v) treatment impact on patients' lives.

Conclusion

Significant physical and psychosocial impacts of periodontitis on patients' lives were identified, along with critical gaps in knowledge and awareness, emphasizing the important role of dentists in patient education. Specific PROs for use in validated instruments tailored to periodontitis were identified. These results can enhance patient-centred care by guiding future studies in accurately assessing patient perspectives on their condition and treatment.

目的患者报告结果（PROs）在指导临床决策方面具有很大的潜力，但其在牙周试验中的应用却很有限。本系统性综述旨在批判性地综合和分析定性研究，这些研究评估了牙周炎及其治疗对患者生活的了解和影响，以及患者寻求治疗的动机、期望和经历。使用 JBI Critical Appraisal 和 ConQual 工具对研究进行了质量评估。结果从 2006 年到 2023 年横跨四大洲的 13 项研究，涉及 215 名参与者，确定了与牙周炎相关的五个主题：(i) 对牙周炎及其治疗的了解；(ii) 牙周炎对患者生活的影响；(iii) 治疗动机和治疗期望；(iv) 治疗障碍；以及 (v) 治疗对患者生活的影响。结论确定了牙周炎对患者生活造成的重大生理和心理影响，以及在知识和认识方面存在的重大差距，强调了牙科医生在患者教育方面的重要作用。研究还确定了可用于专门针对牙周炎的验证工具的特定PROs。这些结果可以指导未来的研究准确评估患者对其病情和治疗的看法，从而加强以患者为中心的护理。

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引用次数: 0

Ten-Year Follow-Up of Oral Implants in Bone With Limited Bucco-Oral Dimensions: A Prospective Case Series 颊-口腔尺寸有限的骨内口腔种植体的十年随访：前瞻性病例系列

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-25 DOI: 10.1111/jcpe.14063

M. Alami, N. Ntovas, G. Penne, W. Teughels, M. Quirynen, A. Castro, A. Temmerman

Background

It has been suggested that 1–2 mm of bone width at the buccal and lingual aspect is required for a successful long-term implant outcome. Low levels of evidence support this minimum threshold of bone width. This prospective study aimed at evaluating the outcome of implants placed in alveolar ridges with limited bucco-oral dimensions.

Materials and Methods

One-hundred implants (dia. 3.5 mm) were placed in 28 patients with narrow alveolar ridge dimensions (<4.5 mm width) without augmentation procedures and conventionally loaded. Intra-oral radiographs were taken at implant placement and abutment connection and at 1, 2, 3, 5 and 10 years of follow-up. At the 10-year follow-up (21 patients; 75 implants), full-mouth periodontal charting was performed, and the peri-implant keratinized tissue width and attachment type were recorded. Two calibrated periodontists analysed the peri-implant bone changes.

Results

After 10 years, all implants showed successful osseointegration and a cumulative survival rate of 100%. The implants were placed 0.85 mm ± 0.89 mm subcrestally. After 10 years, the marginal bone was located 1.59 ± 2.11 mm apical to the implant shoulder. Throughout this period of follow-up, the mean annual marginal bone loss was 0.094 mm. Furthermore, 84% of implants in 72% of patients presented with bleeding on probing.

Conclusion

After 10 years of functional loading, implants placed in alveolar ridges with limited bucco-oral dimensions (≤4.5 mm) exhibited only minimum marginal bone loss.

背景有人认为，要想获得成功的长期种植效果，颊侧和舌侧的骨宽度必须达到 1-2 毫米。支持这一最小骨宽度阈值的证据较少。这项前瞻性研究旨在评估在颊--口腔尺寸有限的牙槽脊上植入种植体的效果。材料和方法在 28 名牙槽脊尺寸狭窄（宽度为 4.5 毫米）的患者中植入了 100 个种植体（直径为 3.5 毫米），这些种植体没有经过扩增程序，采用传统方式植入。在植入种植体和基台连接处以及 1、2、3、5 和 10 年的随访期间拍摄了口腔内放射线照片。在 10 年的随访中（21 名患者；75 个种植体），进行了全口牙周制图，记录了种植体周围角化组织的宽度和附着类型。结果10年后，所有种植体均成功实现骨结合，累积存活率为100%。种植体植入胸骨下 0.85 毫米 ± 0.89 毫米。10 年后，边缘骨位于种植体肩部 1.59 ± 2.11 mm 的顶端。在整个随访期间，平均每年的边缘骨损失为 0.094 毫米。此外，72% 患者的 84% 种植体在探诊时有出血现象。结论经过 10 年的功能负荷后，在颊-口腔尺寸有限（≤4.5 毫米）的牙槽脊上植入的种植体仅表现出最低限度的边缘骨流失。

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引用次数: 0

Is Starch Intake Associated With Periodontal Status? An 11‐Year Longitudinal Analysis Among Finnish Adults 淀粉摄入量与牙周状况有关吗？芬兰成年人 11 年的纵向分析

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-25 DOI: 10.1111/jcpe.14072

F. H. Jangda, A. L. Suominen, A. Lundqvist, S. Männistö, A. Golkari, E. Bernabé

AimTo evaluate the association between baseline starch intake (amount and sources) and changes in periodontal status over 11 years in adults.MethodsAdults aged 30–82 years, who participated in the Finnish Health 2000 survey and were re‐examined in 2004/2005 and/or 2011 were included in the study. The consumption of total starch and six relevant food groups (potatoes, fried potatoes, roots and tubers, pasta, wholegrains and legumes) over the past year was determined at baseline with a validated food frequency questionnaire. The number of teeth with periodontal pocketing ≥ 4 mm (NTPP) was recorded during clinical examinations in 2000, 2004/2005 and 2011. The association between baseline starch intake and the 11‐year change in the NTPP was tested in mixed‐effects negative binomial regression models, adjusting for covariates.ResultsA total of 1369 adults were included in the analysis. The mean NTPP was 4.1 ± 5.6, 6.3 ± 5.6, and 4.8 ± 5.9 in waves 1, 2 and 3, respectively. Baseline starch intake (in g/day or % energy intake) was not associated with changes in the NTPP after adjustment for covariates. In analysis by food groups, the baseline intake of wholegrains was negatively associated with the NTPP at baseline.ConclusionThis study found no evidence of an association between baseline starch intake and changes in periodontal status. Baseline intake of wholegrains was associated with better periodontal status at baseline.

目的评估基线淀粉摄入量（数量和来源）与成年人牙周状况在11年中的变化之间的关系。方法将参加芬兰2000年健康调查并在2004/2005年和/或2011年接受复查的30-82岁成年人纳入研究。在基线期，通过有效的食物频率问卷调查确定过去一年总淀粉和六类相关食物（马铃薯、油炸马铃薯、块根和块茎、面食、全麦和豆类）的消费量。2000年、2004/2005年和2011年的临床检查记录了牙周袋≥4毫米（NTPP）的牙齿数量。在混合效应负二项回归模型中检验了基线淀粉摄入量与11年NTPP变化之间的关系，并对协变量进行了调整。第 1、2 和 3 波的平均 NTPP 分别为 4.1 ± 5.6、6.3 ± 5.6 和 4.8 ± 5.9。基线淀粉摄入量（克/天或能量摄入百分比）与共变因素调整后的 NTPP 变化无关。结论本研究没有发现基线淀粉摄入量与牙周状况变化之间存在关联的证据。全谷物的基线摄入量与基线牙周状况的改善有关。

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引用次数: 0

Extracellular Release of a Disintegrin and Metalloproteinase Correlates With Periodontal Disease Severity 细胞外崩解素和金属蛋白酶的释放与牙周病严重程度有关

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-24 DOI: 10.1111/jcpe.14073

Ahmad Aljohmani, Hakon Heinze, Federico Guillermo Gharzia, Bashar Reda, Ahmed Mohamed Mostafa Abdrabou, Sören L. Becker, Markus Bischoff, Matthias Hannig, Daniela Yildiz

Aim

Periodontal disease is driven by oral pathogens, including Porphyromonas gingivalis, and the release of inflammatory cytokines. These cytokines (e.g., TNF) or their receptors (e.g., IL-1R) are substrates of a disintegrin and metalloproteinases (ADAMs). In this study, we aimed to determine the effects of ADAMs on periodontal disease phenotypes.

Materials and Methods

Western blot and FRET-based activity measurements of the gingival crevicular fluid (GCF) of patients were compared with those of infected (P. gingivalis) or cytokine-stimulated oral keratinocytes and primary human neutrophils, respectively. This was accompanied by an analysis of the released extracellular vesicles and MMP9 activity.

Results

In the GCF of patients, ADAM8 protein expression and activity were correlated with disease stage, whereas ADAM10 protein expression was inversely correlated with disease stage. Infection and the resulting cytokine release orchestrated the release of soluble ADAM8 by oral keratinocytes and primary neutrophils as soluble ectodomain and on exosomes, respectively. Furthermore, ADAM8 regulated the release of ADAM10 and MMP9.

Conclusion

Dysregulation of cell-associated and extracellular ADAM proteolytic activity may be an essential regulatory element in the progression of periodontal disease driven by ADAM8. The influence of ADAM8 on disease onset and the evaluation of targeting ADAM8 as a potential and novel local treatment option should be addressed in future translational in vivo studies.

目的牙周疾病是由包括牙龈卟啉单胞菌在内的口腔病原体和炎性细胞因子的释放引起的。这些细胞因子（如 TNF）或其受体（如 IL-1R）是崩解酶和金属蛋白酶（ADAMs）的底物。在本研究中，我们旨在确定 ADAMs 对牙周疾病表型的影响。材料与方法分别将患者牙龈缝隙液（GCF）的 Western 印迹和 FRET 活性测量结果与受感染（牙龈脓疱病）或细胞因子刺激的口腔角质形成细胞和原代人类中性粒细胞的测量结果进行比较。结果在患者的 GCF 中，ADAM8 蛋白表达和活性与疾病分期相关，而 ADAM10 蛋白表达与疾病分期成反比。感染和由此导致的细胞因子释放分别协调了口腔角质形成细胞和原发性中性粒细胞以可溶性外域和外泌体的形式释放可溶性 ADAM8。此外，ADAM8 还能调节 ADAM10 和 MMP9 的释放。结论细胞相关和细胞外 ADAM 蛋白水解活性的失调可能是 ADAM8 驱动牙周病进展的一个重要调节因素。ADAM8 对疾病发生的影响以及将 ADAM8 作为一种潜在的新型局部治疗方案的评估，应在未来的体内转化研究中加以探讨。

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引用次数: 0

Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment 牙周炎进展期间和牙周治疗后的龈沟液生物标志物

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-15 DOI: 10.1111/jcpe.14061

Flavia Teles, Lynn Martin, Michele Patel, Weiming Hu, Kyle Bittinger, Michael J. Kallan, Ganesh Chandrasekaran, Andrew J. Cucchiara, William V. Giannobile, Danielle Stephens, Alpdogan Kantarci

Objective

To identify gingival crevicular fluid (GCF)-derived inflammatory markers of periodontitis progression and periodontal treatment impact.

Methods

Periodontally healthy (H; n = 112) and periodontitis (P; n = 302) patients were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT). Levels of 64 biomarkers were measured in the GCF samples collected at each visit from progressing (n = 12 sites in H; n = 76 in P) and stable (n = 100 in H, n = 225 in P) sites. Clinical parameters and log-transformed analyte levels were averaged within clinical groups at each time point and analysed using linear mixed models.

Results

During monitoring, progressing sites had significantly higher levels of IL-1β, MMP-8, IL-12p40, EGF and VEGF. MMP-9 and Periostin were significantly more elevated in stable sites. Distinct cytokine profiles were observed based on baseline PD. Treatment led to significant reductions in Eotaxin, Flt-3L, GDF-15, GM-CSF, IL-1β, IL-17, MIP-1d, RANTES and sCD40L, and increases in IP-10 and MMP-9.

Conclusion

Distinct cytokine signatures observed in stable and progressing sites were maintained over time in the absence of treatment and significantly affected by NSPT.

目的确定牙龈缝隙液（GCF）衍生的牙周炎进展和牙周治疗影响的炎症标志物：方法：对牙周健康（H；n = 112）和牙周炎（P；n = 302）患者进行为期一年的双月监测。牙周炎患者在接受非手术牙周治疗（NSPT）6个月后接受复查。在每次就诊时从进展期（H = 12 个部位；P = 76 个部位）和稳定期（H = 100 个部位；P = 225 个部位）采集的 GCF 样本中测量了 64 种生物标志物的水平。临床参数和对数转换的分析物水平在每个时间点的临床组内取平均值，并使用线性混合模型进行分析：结果：在监测过程中，进展部位的 IL-1β、MMP-8、IL-12p40、EGF 和 VEGF 水平明显升高。MMP-9和Periostin在稳定部位明显升高。根据基线PD观察到不同的细胞因子特征。治疗导致Eotaxin、Flt-3L、GDF-15、GM-CSF、IL-1β、IL-17、MIP-1d、RANTES和sCD40L明显降低，IP-10和MMP-9升高：结论：在稳定和进展部位观察到的不同细胞因子特征在没有治疗的情况下长期存在，并受到NSPT的显著影响。

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引用次数: 0

Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long-Term Follow-Up of the PAROKRANK Study 牙周炎会增加未来心血管事件的风险吗？PAROKRANK研究的长期随访。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-11 DOI: 10.1111/jcpe.14064

Anna Norhammar, Per Näsman, Kåre Buhlin, Ulf de Faire, Giulia Ferrannini, Anders Gustafsson, Barbro Kjellström, Thomas Kvist, Eva Levring Jäghagen, Bertil Lindahl, Åke Nygren, Ulf Näslund, Elisabet Svenungsson, Björn Klinge, Lars Rydén, for the PAROKRANK Study Group

Background and Aim

The study ‘Periodontitis and Its Relation to Coronary Artery Disease’ (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD—compared to periodontally healthy individuals—are at increased risk for cardiovascular (CV) events and death.

Methods

A total of 1587 participants (age <75 years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (≥80% alveolar bone height), mild/moderate (79%–66%) or severe (<66%). A composite CV event (first of all-cause death, non-fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow-up period of 9.9 years (range 0.2–12.5 years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan–Meier method and Cox regression.

Results

The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%; p < 0.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] = 1.26; 95% CI: 1.01–1.57; p = 0.038), following adjustment for age, smoking and diabetes.

Conclusion

The PAROKRANK follow-up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.

背景和目的 "牙周炎及其与冠状动脉疾病的关系"（PAROKRANK）研究报告了牙周炎（PD）与首次心肌梗塞（MI）之间的关系。本后续研究旨在验证以下假设：与牙周健康的人相比，患有牙周炎的人发生心血管（CV）事件和死亡的风险更高。方法共有 1587 名参与者（年龄小于 75 岁；女性占 19%）在 2010 年至 2014 年期间进行了牙科检查，包括全景 X 光片。牙周病分为健康（牙槽骨高度≥80%）、轻度/中度（79%-66%）或重度（<66%）。在平均 9.9 年（0.2-12.5 年）的随访期间，对复合心血管事件（首次全因死亡、非致命性心肌梗死或中风以及心力衰竭住院）进行了调查。参与者被分为两组：有和没有帕金森病的患者。结果985名牙周健康的参与者中发生了187起事件（19%），602名患有帕金森病的参与者中发生了174起事件（29%；P < 0.0001）。在对年龄、吸烟和糖尿病等因素进行调整后，患有牙周病的参与者未来发生事件的可能性更高（危险比 [HR] = 1.26；95% CI：1.01-1.57；p = 0.038）。

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引用次数: 0

The Potential Effect of Periodontal Disease on the Development of Metabolic Syndrome: A 10-Year Observational Study in a Thai Adult Cohort. 牙周病对代谢综合征发展的潜在影响：一项为期 10 年的泰国成人队列观察研究。

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-10 DOI: 10.1111/jcpe.14068

Benjar Issaranggun Na Ayuthaya,Attawood Lertpimonchai,Lakshman Samaranayake,Prin Vathesatogkit,Lalitsara Thienpramuk,Wichaya Wisitrasameewong,Suphot Tamsailom

AIMAs data are sparse on the long-term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over a 10-year observational period.METHODSMedical records and data on periodontal assessments of 2161 employees of the Electricity Generating Authority of Thailand collected at two time points, 2003 and 2013, were used. Experienced periodontists used standard national and international criteria to define periodontitis and MetS. The impact of baseline periodontitis on subsequent MetS incidence and its components was evaluated using regression analyses.RESULTSThe severity and extent of periodontitis significantly predicted MetS incidence over a decade, with a higher incidence of MetS in individuals with poorer periodontal health. A single percentage increase in the periodontitis extent raised the risk of MetS incidence by 0.4% and the risk of developing individual components of MetS by 0.2%. Independent of periodontal health, age of an individual emerged as a factor impacting MetS development.CONCLUSIONThis study highlights the potential effect of the severity and extent of periodontitis on the increased incidence and progression of MetS. Hyperglycaemia and hypertension were the two MetS components most significantly affected by the existence of periodontitis.

目的由于有关牙周疾病与代谢综合征（MetS）发展之间长期关系的数据稀少，我们在泰国的一个队列中调查了这两者之间长达 10 年的观察期关系。方法使用 2003 年和 2013 年两个时间点收集的泰国发电局 2161 名员工的医疗记录和牙周评估数据。经验丰富的牙周病专家采用标准的国内和国际标准来定义牙周炎和 MetS。结果牙周炎的严重程度和范围可显著预测十年内 MetS 的发病率，牙周健康状况较差的人 MetS 发病率较高。牙周炎程度每增加一个百分点，MetS的发病风险就会增加0.4%，而MetS各组成部分的发病风险则会增加0.2%。结论：本研究强调了牙周炎的严重程度和范围对 MetS 的发病率增加和发展的潜在影响。高血糖和高血压是受牙周炎影响最大的两种 MetS 成分。

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引用次数: 0

Effect of Discontinuation of Supportive Periodontal Therapy on Periodontal Status—A Retrospective Study 停止牙周支持疗法对牙周状况的影响--一项回顾性研究。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-05 DOI: 10.1111/jcpe.14062

Thomas Kocher, Karoline Lösler, Christiane Pink, Hans Jörgen Grabe, Birte Holtfreter

Aim

To assess the impact of active (APT) and supportive periodontal therapy (SPT) on the change in probing depth (PD) and annual tooth loss in partially and fully compliant and drop-out patients.

Material and Methods

Data of 280 periodontally treated partially and fully compliant (regular supportive visits, SPT duration 5.5 ± 4.5 years) and 55 drop-out patients (SPT and drop-out duration 8.3 ± 3.8 years, only drop-out duration 5.3 ± 3.7 years) were recorded. PD data and the number of teeth present at the start of APT (T1) and at the start of SPT (T2) were taken from the patient files and evaluated at the time of the final examination (T3).

Results

Annual tooth loss during SPT was significantly higher (p < 0.001) in drop-out patients than in partially and fully compliant patients (0.31 ± 0.50 vs. 0.19 ± 0.55, respectively). In partially and fully compliant and drop-out patients, the mean PD (all available site data) decreased significantly between T1 (3.61 ± 0.82 vs. 3.70 ± 0.73 mm) and T2 (2.68 ± 0.40 vs. 2.76 ± 0.42 mm), while the values increased again slightly up to T3 (2.74 ± 0.41 vs. 2.99 ± 0.75 mm).

Conclusions

In partially and fully compliant patients, SPT had a positive impact on PD stability and medium-term tooth preservation. In contrary to expectations, drop-out patients, PD did not return to baseline values, although PD stability was not achieved.

目的：评估积极牙周治疗（APT）和支持性牙周治疗（SPT）对部分和完全达标以及辍学患者探诊深度（PD）变化和年牙齿脱落的影响：记录了280名牙周治疗部分达标和完全达标患者（定期支持性就诊，SPT持续时间为5.5 ± 4.5年）以及55名辍学患者（SPT和辍学持续时间为8.3 ± 3.8年，仅辍学持续时间为5.3 ± 3.7年）的数据。从患者档案中获取PD数据以及APT开始时（T1）和SPT开始时（T2）的牙齿数量，并在最终检查时（T3）进行评估：结果：SPT期间的年牙齿脱落率明显更高（p 结论：SPT期间的年牙齿脱落率明显高于APT期间：在部分和完全达标的患者中，SPT 对 PD 稳定性和中期牙齿保存有积极影响。与预期相反，退出的患者虽然没有达到 PD 稳定度，但 PD 没有恢复到基线值。

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引用次数: 0