Journal of Clinical Periodontology最新文献_第2页

Non-Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross-Linked Hyaluronic Acid: A Single-Blinded Randomized Controlled Clinical Trial. 使用交联透明质酸对中度牙周骨内缺陷进行非手术治疗：单盲随机对照临床试验。

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-14 DOI: 10.1111/jcpe.14078

Vincenzo Iorio-Siciliano,Andrea Blasi,Leopoldo Mauriello,Giovanni E Salvi,Luca Ramaglia,Anton Sculean

AIMTo evaluate the clinical outcomes of moderate intrabony defects treated with minimally invasive non-surgical technique (MINST) with or without adjunctive delivery of cross-linked hyaluronic acid (xHyA) gel.MATERIALS AND METHODSForty-two patients with 42 interdental intrabony defects were randomly assigned to test (MINST + xHyA) or control procedures (MINST alone). Probing depth (PD), clinical attachment level (CAL), gingival recession (GR) and bleeding on probing (BOP) at the treated sites were assessed at baseline and at 3 and 6 months. Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) were recorded at baseline and after 6 months. Radiographic evaluation was performed at baseline and after 6 months, assessing the defect fill (DF) and radiographic defect angle (RDA). The primary outcome variable was PD change.RESULTSThirty-eight patients completed the trial without any adverse events. At 6 months, a statistically significant improvement (p < 0.05) was measured in all clinical parameters except GR (p > 0.05). However, no statistically significant differences were found between the experimental and control procedures (p > 0.05). Statistically significant differences between the test and control sites were observed at 3 months for PD and CAL changes (p < 0.05). The DF change was statistically significant when comparing experimental and control procedures at 6 months (p < 0.05). Both procedures failed to show statistically significant differences in terms of RDA changes at 6 months (p > 0.05).CONCLUSIONWithin their limitations, the present results indicate that (a) treatment of intrabony defects with MINST, with or without application of xHyA gel, resulted in statistically significant improvements in the investigated clinical parameters at 3 and 6 months after therapy, and (b) although the adjunctive use of xHyA gel to MINST improved the clinical outcomes compared with MINST alone up to 3 months, statistically significant differences were not observed at 6 months. The study protocol was registered in ClinicalTrial.gov (NCT05188898).

材料与方法将42例牙间隙缺损患者随机分配到试验组（MINST + xHyA）或对照组（仅MINST）。在基线期、3 个月和 6 个月时评估治疗部位的探诊深度 (PD)、临床附着水平 (CAL)、牙龈退缩 (GR) 和探诊出血 (BOP)。在基线和 6 个月后记录全口牙菌斑评分（FMPS）和全口出血评分（FMBS）。在基线和 6 个月后进行放射学评估，评估缺损填充（DF）和放射学缺损角度（RDA）。结果38名患者完成了试验，未出现任何不良反应。6个月后，患者的病情有了显著改善（P 0.05）。然而，试验程序和对照程序之间没有发现明显的统计学差异（P > 0.05）。在 3 个月时，试验点和对照点之间在 PD 和 CAL 变化方面有明显的统计学差异（P 0.05）。结论尽管存在局限性，但本研究结果表明：(a) 使用 MINST（无论是否使用 xHyA 凝胶）治疗骨内缺损可在治疗后 3 个月和 6 个月时显著改善所调查的临床参数；(b) 虽然在 MINST 的基础上辅助使用 xHyA 凝胶可在 3 个月内改善临床结果，但在 6 个月时未观察到显著的统计学差异。该研究方案已在 ClinicalTrial.gov (NCT05188898) 上注册。

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引用次数: 0

Lockd Enhances Mandibular Mesenchymal Stem Cell Proliferation While Inhibiting Osteogenic Capability via Binding With SUZ12 in the Inflammatory Microenvironment. Lockd通过与炎症微环境中的SUZ12结合，增强下颌骨间充质干细胞增殖，同时抑制成骨能力。

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-14 DOI: 10.1111/jcpe.14076

Yahui Lu,Xiaolei Ruan,Gang Xiao,Yueming Dai,Gen Li,Guanhui Cai,Lihe Zheng,Zhaolan Guan,Wen Sun,Hua Wang

AIMTo investigate the role of lncRNA Lockd in mandibular mesenchymal stem cell (M-MSC) proliferation and osteogenic capability in the inflammatory microenvironment, focusing on its interaction with SUZ12.MATERIALS AND METHODSUsing lncR Lockd knockdown/overexpression cell models and a murine periodontitis model, we explored Lockd's effects on M-MSC proliferation and osteogenic capability in the inflammatory microenvironment. Predictions from multiple databases and a series of rescue experiments revealed the regulatory role of the Lockd/SUZ12 signalling axis of M-MSC in the inflammatory microenvironment.RESULTSLockd was found to stimulate M-MSC proliferation but impair osteogenic differentiation. The in vitro studies suggested that the activation of Lockd negatively inhibited the osteogenic differentiation process and may ultimately impact bone formation in periodontitis. Mechanistically, it was elucidated that Lockd interacts with SUZ12, a core component of the polycomb repressive complex 2 (PRC2), and may affect the PRC2 complex's role in osteogenic gene expression.CONCLUSIONSLockd boosts the proliferation of M-MSCs but inhibits their osteogenic differentiation by interacting with SUZ12, potentially inhibiting osteogenic capability in the inflammatory microenvironment.

目的研究lncRNA Lockd在炎症微环境中下颌骨间充质干细胞（M-MSC）增殖和成骨能力中的作用，重点是其与SUZ12的相互作用。材料与方法利用lncR Lockd敲除/外显细胞模型和小鼠牙周炎模型，我们探讨了Lockd在炎症微环境中对M-MSC增殖和成骨能力的影响。来自多个数据库的预测和一系列挽救实验揭示了 Lockd/SUZ12 信号轴在炎症微环境中对 M-MSC 的调控作用。体外研究表明，Lockd 的激活对成骨分化过程有负面抑制作用，并可能最终影响牙周炎的骨形成。从机理上阐明了Lockd与多聚核抑制复合体2（PRC2）的核心成分SUZ12相互作用，并可能影响PRC2复合体在成骨基因表达中的作用。

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引用次数: 0

Effect of a Whole-Food Plant-Based Diet on Periodontal Parameters in Patients With Cardiovascular Risk Factors: A Secondary Sub-Analysis of a Randomized Clinical Trial. 基于全食物植物的饮食对心血管风险因素患者牙周参数的影响：一项随机临床试验的二次分析。

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-14 DOI: 10.1111/jcpe.14066

C L Pappe,S Lutzenberger,K Goebler,S Meier,M Jeitler,A Michalsen,H Dommisch

AIMTo investigate the effect of a 16-week whole-food plant-based diet (WPBD) on periodontal parameters in patients with increased cardiometabolic risk.MATERIALS AND METHODSA total of 36 participants from a randomized clinical trial received additional periodontal assessment. The intervention group (n = 17) followed a WPBD for 16 weeks, whereas the control group (CG) (n = 19) was instructed not to change their diet. Measurements were assessed at baseline (t1), week 8 (t2) and week 16 (t3). Periodontal examination included bleeding on probing (BOP), periodontal inflamed surface area (PISA) and plaque index (PI) on six index teeth, salivary pH and matrix-matalloproteinase-8 (MMP-8).RESULTSAt t3, the mean PISA of the index teeth was reduced by 32 mm2 (53.8) in the WPBD group and increased by 22.6 mm2 (45.1) in the CG group (intra-group p = 0.255 and p = 0.977, respectively), BOP changes were similar (intra-group p = 0.89 and p = 0.839, respectively). MMP-8 values reduced in the WPBD group by 50.73 ng/mL (117) and in the CG by 5.40 ng/mL (96.6) (intra-group p = 0.066, p = 0.837, respectively). Difference in change (t3 - t1) between the groups was p = 0.001, p = 0.003 and p = 0.032, respectively. Saliva pH increased in the WPBD group only (intra-group p = 0.007).CONCLUSIONA trend towards stabilization of the inflammatory parameters (BOP, PISA) was observed in the WPBD group. Because of the non-significant changes within the groups, this study highlights the imperative for future studies.CLINICALTRIALSGOV IDENTIFIERNCT03901183.

材料和方法一项随机临床试验的 36 名参与者接受了额外的牙周评估。干预组（n = 17）接受为期 16 周的 WPBD，而对照组（n = 19）则接受不改变饮食习惯的指导。分别在基线（t1）、第 8 周（t2）和第 16 周（t3）进行评估。牙周检查包括探诊出血（BOP）、牙周炎症表面积（PISA）和六颗牙齿的牙菌斑指数（PI）、唾液 pH 值和基质金属蛋白酶-8（MMP-8）。8），CG 组增加了 22.6 平方毫米（45.1）（组内 p = 0.255 和 p = 0.977），BOP 变化相似（组内 p = 0.89 和 p = 0.839）。WPBD 组的 MMP-8 值减少了 50.73 纳克/毫升（117），CG 组减少了 5.40 纳克/毫升（96.6）（组内 p = 0.066，组间 p = 0.837）。组间变化（t3 - t1）差异分别为 p = 0.001、p = 0.003 和 p = 0.032。结论 WPBD 组的炎症参数（BOP、PISA）呈稳定趋势。由于组内变化不显著，本研究强调了未来研究的必要性。

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引用次数: 0

Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) 膳食模式与龈下微生物群之间的关系：口腔感染、葡萄糖不耐受和胰岛素抵抗研究（ORIGINS）的结果

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-12 DOI: 10.1111/jcpe.14067

Rebecca L. Molinsky, Abigail J. Johnson, Lisa Marotz, Sumith Roy, Bruno Bohn, Charlene E. Goh, Ching‐Yuan Chen, Bruce Paster, Rob Knight, Jeanine Genkinger, Panos N. Papapanou, David R. Jacobs, Ryan T. Demmer

ObjectiveTo study the association between dietary patterns and subgingival microbiota.MethodsParticipants (n = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival plaque sampling (n = 890 plaques) and a dietary assessment were included. 16S rRNA gene amplicon sequences of subgingival plaque from sites with either probing depth <4 or ≥4 mm were processed separately and used to obtain α‐diversity metrics (Faith, Shannon, Simpson, Observed) and taxa ratios (Red Complex to Corynebacterium [RCLR], Treponema to Corynebacterium [TCLR], and Treponema to Neisseria [TNLR]). Food frequency questionnaires (FFQs) were processed to calculate Alternate Healthy Eating Index (AHEI) and A Priori Diet Quality Score (APDQS) scores. Mixed regression models examined the mean levels of microbial metrics across quartiles of diet quality. Means ± standard errors are reported along with p‐values.ResultsIn multivariable models assessing the association between diet scores and α‐diversity metrics, higher AHEI values were significantly associated with lower Faith (p‐value = 0.01) and Observed (p‐value = 0.04) diversity values; similar findings were observed for APDQS (p‐value = 0.01, p‐value = 0.04). In multivariable models assessing the association between diet scores (AHEI and APDQS) and taxa ratios (RCLR, TCLR and TNLR), as the AHEI quartile increased, all taxa ratios decreased significantly as follows: −1.06 ± 0.093 in Q1 to −1.34 ± 0.099 in Q4 (RCLR), −0.43 ± 0.077 in Q1 to −0.64 ± 0.083 in Q4 (TCLR) and −0.09 ± 0.083 in Q1 to −0.38 ± 0.089 in Q4 (TNLR), respectively. In contrast, as the APDQS quartiles increased, only TNLR decreased significantly from −0.08 ± 0.085 in Q1 to −0.34 ± 0.091 in Q4.ConclusionDiets rich in fruits, vegetables, whole grains and other nutritionally rich plant foods are associated with lower oral microbial diversity and favourable ratios of pathogenic to commensal microbiota.

方法纳入参加口腔感染、葡萄糖不耐受和胰岛素抵抗研究（ORIGINS）并进行龈下菌斑采样（890 个菌斑）和饮食评估的参与者（n = 651）。对探查深度为 4 毫米或≥4 毫米的龈下斑块的 16S rRNA 基因扩增片段序列分别进行处理，并用于获得 α 多样性指标（费斯、香农、辛普森、观察）和类群比（红色复合菌与棒状杆菌 [RCLR]、特雷波菌与棒状杆菌 [TCLR] 和特雷波菌与奈瑟菌 [TNLR]）。对食物频率问卷（FFQ）进行处理，以计算替代健康饮食指数（AHEI）和先验饮食质量评分（APDQS）。混合回归模型检验了膳食质量四分位数中微生物指标的平均水平。结果在评估饮食评分与 α 多样性指标之间关系的多变量模型中，AHEI 值越高，信仰值（p-value = 0.01）和观察值（p-value = 0.04）越低；APDQS 也有类似结果（p-value = 0.01，p-value = 0.04）。在评估膳食评分（AHEI 和 APDQS）与分类群比率（RCLR、TCLR 和 TNLR）之间关系的多变量模型中，随着 AHEI 四分位数的增加，所有分类群比率均显著下降，具体情况如下：从第一季度的-1.06 ± 0.093 到第四季度的-1.34 ± 0.099（RCLR），从第一季度的-0.43 ± 0.077 到第四季度的-0.64 ± 0.083（TCLR），从第一季度的-0.09 ± 0.083 到第四季度的-0.38 ± 0.089（TNLR）。相比之下，随着 APDQS 四分位数的增加，只有 TNLR 从第一季度的 -0.08 ± 0.085 显著下降到第四季度的 -0.34 ± 0.091。

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引用次数: 0

Wide Restorative Emergence Angle Increases Marginal Bone Loss and Impairs Integrity of the Junctional Epithelium of the Implant Supracrestal Complex: A Preclinical Study. 较宽的修复体暴露角会增加边缘骨丧失并损害种植体上颌联合上皮的完整性：临床前研究。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-09 DOI: 10.1111/jcpe.14070

Franz J Strauss, Jin-Young Park, Jung-Seok Lee, Lucia Schiavon, Rawen Smirani, Sonja Hitz, Jennifer G M Chantler, Nikos Mattheos, Ronald Jung, Dieter Bosshardt, Jae-Kook Cha, Daniel Thoma

Aim: To assess the influence of the emergence angle on marginal bone loss (MBL) and supracrestal soft tissue around dental implants.

Materials and methods: In six mongrel dogs, the mandibular premolars and molars were extracted. After 3 months of healing, four dental implants were placed in each hemimandible. The implants were randomly allocated to receive one of four customized healing abutments, each with a different value of the restorative emergence angle: 20°, 40°, 60° or 80°. Intra-oral radiographs were taken after placing the healing abutments and at 6, 9, 16 and 24 weeks of follow-up. Then, micro-CT and undecalcified histology and synchrotron were performed. MBL over time was analysed with generalized estimating equations (GEEs) and adjusted for baseline soft-tissue thickness.

Results: From implant placement to 24 weeks, GEE modelling showed that the MBL at mesial and distal sites consistently increased over time, indicating MBL in all groups (p < 0.001). The model indicated that MBL varied significantly across the different restorative angles (angle effect, p < 0.001), with 80° showing the greatest bone loss. Micro-CT, histology and synchrotron confirmed the corresponding trends and showed that wide restorative angles (60° and 80°) impaired the integrity of the junctional epithelium of the supracrestal tissue.

Conclusions: A wide restorative angle increases MBL and impairs the integrity of the junctional epithelium of the implant supracrestal complex.

目的：评估出牙角对牙科种植体周围边缘骨损失（MBL）和上软组织的影响：在六只杂种狗中拔除下颌前磨牙和臼齿。3 个月愈合后，在每个半下颌植入 4 个种植体。种植体被随机分配到四个定制的愈合基台中的一个，每个基台的修复萌出角值不同：20°、40°、60°或80°。植入愈合基台后，分别在 6 周、9 周、16 周和 24 周的随访期间拍摄口内 X 光片。然后进行显微 CT 和未脱钙组织学检查以及同步加速器检查。使用广义估计方程（GEEs）分析了随时间变化的 MBL，并根据基线软组织厚度进行了调整：结果：从种植体植入到 24 周，GEE 模型显示，中轴和远轴部位的 MBL 随时间持续增加，表明所有组的 MBL 都增加了（p 结论：从种植体植入到 24 周，GEE 模型显示，中轴和远轴部位的 MBL 随时间持续增加，表明所有组的 MBL 都增加了：较宽的修复角会增加 MBL，并损害种植体嵴上复合体连接上皮的完整性。

{"title":"Wide Restorative Emergence Angle Increases Marginal Bone Loss and Impairs Integrity of the Junctional Epithelium of the Implant Supracrestal Complex: A Preclinical Study.","authors":"Franz J Strauss, Jin-Young Park, Jung-Seok Lee, Lucia Schiavon, Rawen Smirani, Sonja Hitz, Jennifer G M Chantler, Nikos Mattheos, Ronald Jung, Dieter Bosshardt, Jae-Kook Cha, Daniel Thoma","doi":"10.1111/jcpe.14070","DOIUrl":"https://doi.org/10.1111/jcpe.14070","url":null,"abstract":"Aim: To assess the influence of the emergence angle on marginal bone loss (MBL) and supracrestal soft tissue around dental implants.Materials and methods: In six mongrel dogs, the mandibular premolars and molars were extracted. After 3 months of healing, four dental implants were placed in each hemimandible. The implants were randomly allocated to receive one of four customized healing abutments, each with a different value of the restorative emergence angle: 20°, 40°, 60° or 80°. Intra-oral radiographs were taken after placing the healing abutments and at 6, 9, 16 and 24 weeks of follow-up. Then, micro-CT and undecalcified histology and synchrotron were performed. MBL over time was analysed with generalized estimating equations (GEEs) and adjusted for baseline soft-tissue thickness.Results: From implant placement to 24 weeks, GEE modelling showed that the MBL at mesial and distal sites consistently increased over time, indicating MBL in all groups (p < 0.001). The model indicated that MBL varied significantly across the different restorative angles (angle effect, p < 0.001), with 80° showing the greatest bone loss. Micro-CT, histology and synchrotron confirmed the corresponding trends and showed that wide restorative angles (60° and 80°) impaired the integrity of the junctional epithelium of the supracrestal tissue.Conclusions: A wide restorative angle increases MBL and impairs the integrity of the junctional epithelium of the implant supracrestal complex.","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrast-Enhanced Micro-CT Imaging of Murine Mandibles: A Multi-Method Approach for Simultaneous Hard and Soft Tissue Analysis. 小鼠下颌骨的对比度增强显微 CT 成像：多种方法同时分析硬组织和软组织

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-10-03 DOI: 10.1111/jcpe.14077

Torben Hildebrand, Yolanda Humphris, Håvard Jostein Haugen, Liebert Parreiras Nogueira

Aim: To develop and evaluate a novel multi-method micro-computed tomography (μCT) imaging protocol for enhanced visualization of both hard and soft tissues in murine mandibles, addressing the limitations of traditional imaging techniques in dental research.

Materials and methods: We employed a contrast-enhanced (CE) μCT imaging technique using Lugol's iodine as a contrast agent to visualize the intricate structures of murine mandibles. The protocol involved the combination of conventional μCT imaging as well as CE-μCT, including decalcification with EDTA, allowing for simultaneous assessment of hard and soft tissues. The method is compared with standard imaging modalities, and the ability to visualize detailed anatomical features is discussed.

Results: The CE-μCT imaging technique provided superior visualization of murine mandibular structures, including dental pulp, periodontal ligaments and the surrounding soft tissues, along with conventional μCT imaging of alveolar bone and teeth. This method revealed detailed anatomical features with high specificity and contrast, surpassing traditional imaging approaches.

Conclusion: Our findings demonstrate the potential of CE-μCT imaging with Lugol's iodine as a powerful tool for dental research. This technique offers a comprehensive view of the murine mandible, facilitating advanced studies in tissue engineering, dental pathology and the development of dental materials.

目的：针对牙科研究中传统成像技术的局限性，开发并评估一种新型多方法微型计算机断层扫描（μCT）成像方案，以增强对小鼠下颌骨软硬组织的观察：我们采用了一种造影剂增强型（CE）μCT成像技术，使用鲁戈尔碘作为造影剂来观察小鼠下颌骨的复杂结构。该方法结合了传统的μCT成像和CE-μCT成像，包括用乙二胺四乙酸脱钙，可同时评估硬组织和软组织。该方法与标准成像模式进行了比较，并讨论了观察详细解剖特征的能力：结果：与牙槽骨和牙齿的传统μCT成像技术相比，CE-μCT成像技术能更好地观察小鼠下颌骨结构，包括牙髓、牙周韧带和周围软组织。这种方法以高特异性和高对比度显示了详细的解剖特征，超越了传统的成像方法：我们的研究结果表明，使用鲁戈尔碘的 CE-μCT 成像技术是牙科研究的有力工具。这项技术提供了小鼠下颌骨的全面视图，有助于组织工程、牙科病理学和牙科材料开发方面的高级研究。

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引用次数: 0

Periodontitis and Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis. 牙周炎与口腔健康相关的生活质量：系统回顾与元分析》。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-29 DOI: 10.1111/jcpe.14074

Catiusse Crestani Del' Agnese, Caroline Schöffer, Karla Zanini Kantorski, Fabricio Batistin Zanatta, Cristiano Susin, Raquel Pippi Antoniazzi

Aim: To investigate the association between periodontitis and oral health-related quality of life (OHRQoL) in adults, and to compare OHRQoL across different severities of the disease.

Materials and methods: Searches were conducted in five electronic databases up to December 2023. Observational studies that provided a clear definition of periodontitis and used validated measures of OHRQoL were included. Meta-analyses were performed both overall and based on factors that could explain heterogeneity between studies.

Results: Sixty studies comprising 14,851 individuals were included in the review. Meta-analyses showed that periodontitis was associated with impaired OHRQoL: any OHRQoL instruments (n = 33 studies; SMD: 0.75, 95% CI: 0.53-0.93), solely using the OHIP-14 (n = 26 studies; MD: 5.14, 95% CI: 3.64-6.64), and risk assessment (n = 9 studies; adjusted RR: 1.42, 95% CI: 1.12-1.78). Stages III-IV periodontitis had a greater impact than Stages I-II periodontitis. Subgroup and meta-regression analyses indicated smaller effect size estimates for individuals with comorbidities.

Conclusions: Periodontitis negatively impacts OHRQoL, with a positive score-response relationship found between periodontitis severity and poorer OHRQoL. However, the magnitude of this association appears to be diminished in individuals with comorbidities.

目的：研究成人牙周炎与口腔健康相关生活质量（OHRQoL）之间的关系，并比较不同严重程度的牙周炎患者的口腔健康相关生活质量：对截至 2023 年 12 月的五个电子数据库进行了检索。纳入了对牙周炎有明确定义并使用有效的 OHRQoL 测量方法的观察性研究。对研究的总体情况以及可解释研究间异质性的因素进行了元分析：综述共纳入了 60 项研究，涉及 14 851 人。Meta分析表明，牙周炎与OHRQoL受损有关：任何OHRQoL工具（n = 33项研究；SMD：0.75，95% CI：0.53-0.93），仅使用OHIP-14（n = 26项研究；MD：5.14，95% CI：3.64-6.64），以及风险评估（n = 9项研究；调整RR：1.42，95% CI：1.12-1.78）。III-IV 期牙周炎比 I-II 期牙周炎的影响更大。分组和元回归分析表明，合并症患者的效应大小估计值较小：结论：牙周炎对 OHRQoL 有负面影响，牙周炎严重程度与较差的 OHRQoL 之间存在正的分数-反应关系。结论：牙周炎对 OHRQoL 有负面影响，牙周炎严重程度与 OHRQoL 较差之间存在正向的分数-反应关系，但在有合并症的患者中，这种关系的程度似乎有所降低。

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引用次数: 0

Perceptions, Attitudes and Needs of Periodontitis Patients: A Qualitative Systematic Review. 牙周炎患者的认知、态度和需求：定性系统回顾

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-27 DOI: 10.1111/jcpe.14058

Camila Pinheiro Furquim,Lina J Suárez,Renata Tavares,Belén Retamal-Valdes,Murilo Fernando Neuppmann Feres,Magda Feres

AIMPatient-reported outcomes (PROs) hold significant potential in guiding clinical decision making, yet their utilization in periodontal trials has been limited. This systematic review aimed to critically synthesize and analyse qualitative studies that evaluated the knowledge and impact of periodontitis and its treatment on patients' lives, as well as their motivations, expectations and experiences in seeking treatment.MATERIALS AND METHODSSix databases were searched up to March 2024 for qualitative studies on periodontitis patients. Studies were quality-assessed using the JBI Critical Appraisal and ConQual tools. Two authors independently extracted the findings, with discrepancies resolved by a third reviewer.RESULTSThirteen studies from 2006 to 2023 across four continents, involving 215 participants, identified five themes related to periodontitis: (i) knowledge about periodontitis and its treatment; (ii) impact of periodontitis on patients' lives; (iii) motivation and treatment expectations; (iv) obstacles to treatment; and (v) treatment impact on patients' lives.CONCLUSIONSignificant physical and psychosocial impacts of periodontitis on patients' lives were identified, along with critical gaps in knowledge and awareness, emphasizing the important role of dentists in patient education. Specific PROs for use in validated instruments tailored to periodontitis were identified. These results can enhance patient-centred care by guiding future studies in accurately assessing patient perspectives on their condition and treatment.

目的患者报告结果（PROs）在指导临床决策方面具有很大的潜力，但其在牙周试验中的应用却很有限。本系统性综述旨在批判性地综合和分析定性研究，这些研究评估了牙周炎及其治疗对患者生活的了解和影响，以及患者寻求治疗的动机、期望和经历。使用 JBI Critical Appraisal 和 ConQual 工具对研究进行了质量评估。结果从 2006 年到 2023 年横跨四大洲的 13 项研究，涉及 215 名参与者，确定了与牙周炎相关的五个主题：(i) 对牙周炎及其治疗的了解；(ii) 牙周炎对患者生活的影响；(iii) 治疗动机和治疗期望；(iv) 治疗障碍；以及 (v) 治疗对患者生活的影响。结论确定了牙周炎对患者生活造成的重大生理和心理影响，以及在知识和认识方面存在的重大差距，强调了牙科医生在患者教育方面的重要作用。研究还确定了可用于专门针对牙周炎的验证工具的特定PROs。这些结果可以指导未来的研究准确评估患者对其病情和治疗的看法，从而加强以患者为中心的护理。

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引用次数: 0

Ten‐Year Follow‐Up of Oral Implants in Bone With Limited Bucco‐Oral Dimensions: A Prospective Case Series 颊-口腔尺寸有限的骨内口腔种植体的十年随访：前瞻性病例系列

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-26 DOI: 10.1111/jcpe.14063

M. Alami, N. Ntovas, G. Penne, W. Teughels, M. Quirynen, A. Castro, A. Temmerman

BackgroundIt has been suggested that 1–2 mm of bone width at the buccal and lingual aspect is required for a successful long‐term implant outcome. Low levels of evidence support this minimum threshold of bone width. This prospective study aimed at evaluating the outcome of implants placed in alveolar ridges with limited bucco‐oral dimensions.Materials and MethodsOne‐hundred implants (dia. 3.5 mm) were placed in 28 patients with narrow alveolar ridge dimensions (<4.5 mm width) without augmentation procedures and conventionally loaded. Intra‐oral radiographs were taken at implant placement and abutment connection and at 1, 2, 3, 5 and 10 years of follow‐up. At the 10‐year follow‐up (21 patients; 75 implants), full‐mouth periodontal charting was performed, and the peri‐implant keratinized tissue width and attachment type were recorded. Two calibrated periodontists analysed the peri‐implant bone changes.ResultsAfter 10 years, all implants showed successful osseointegration and a cumulative survival rate of 100%. The implants were placed 0.85 mm ± 0.89 mm subcrestally. After 10 years, the marginal bone was located 1.59 ± 2.11 mm apical to the implant shoulder. Throughout this period of follow‐up, the mean annual marginal bone loss was 0.094 mm. Furthermore, 84% of implants in 72% of patients presented with bleeding on probing.ConclusionAfter 10 years of functional loading, implants placed in alveolar ridges with limited bucco‐oral dimensions (≤4.5 mm) exhibited only minimum marginal bone loss.

背景有人认为，要想获得成功的长期种植效果，颊侧和舌侧的骨宽度必须达到 1-2 毫米。支持这一最小骨宽度阈值的证据较少。这项前瞻性研究旨在评估在颊--口腔尺寸有限的牙槽脊上植入种植体的效果。材料和方法在 28 名牙槽脊尺寸狭窄（宽度为 4.5 毫米）的患者中植入了 100 个种植体（直径为 3.5 毫米），这些种植体没有经过扩增程序，采用传统方式植入。在植入种植体和基台连接处以及 1、2、3、5 和 10 年的随访期间拍摄了口腔内放射线照片。在 10 年的随访中（21 名患者；75 个种植体），进行了全口牙周制图，记录了种植体周围角化组织的宽度和附着类型。结果10年后，所有种植体均成功实现骨结合，累积存活率为100%。种植体植入胸骨下 0.85 毫米 ± 0.89 毫米。10 年后，边缘骨位于种植体肩部 1.59 ± 2.11 mm 的顶端。在整个随访期间，平均每年的边缘骨损失为 0.094 毫米。此外，72% 患者的 84% 种植体在探诊时有出血现象。结论经过 10 年的功能负荷后，在颊-口腔尺寸有限（≤4.5 毫米）的牙槽脊上植入的种植体仅表现出最低限度的边缘骨流失。

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引用次数: 0

Is Starch Intake Associated With Periodontal Status? An 11‐Year Longitudinal Analysis Among Finnish Adults 淀粉摄入量与牙周状况有关吗？芬兰成年人 11 年的纵向分析

IF 6.7 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-09-25 DOI: 10.1111/jcpe.14072

F. H. Jangda, A. L. Suominen, A. Lundqvist, S. Männistö, A. Golkari, E. Bernabé

AimTo evaluate the association between baseline starch intake (amount and sources) and changes in periodontal status over 11 years in adults.MethodsAdults aged 30–82 years, who participated in the Finnish Health 2000 survey and were re‐examined in 2004/2005 and/or 2011 were included in the study. The consumption of total starch and six relevant food groups (potatoes, fried potatoes, roots and tubers, pasta, wholegrains and legumes) over the past year was determined at baseline with a validated food frequency questionnaire. The number of teeth with periodontal pocketing ≥ 4 mm (NTPP) was recorded during clinical examinations in 2000, 2004/2005 and 2011. The association between baseline starch intake and the 11‐year change in the NTPP was tested in mixed‐effects negative binomial regression models, adjusting for covariates.ResultsA total of 1369 adults were included in the analysis. The mean NTPP was 4.1 ± 5.6, 6.3 ± 5.6, and 4.8 ± 5.9 in waves 1, 2 and 3, respectively. Baseline starch intake (in g/day or % energy intake) was not associated with changes in the NTPP after adjustment for covariates. In analysis by food groups, the baseline intake of wholegrains was negatively associated with the NTPP at baseline.ConclusionThis study found no evidence of an association between baseline starch intake and changes in periodontal status. Baseline intake of wholegrains was associated with better periodontal status at baseline.

目的评估基线淀粉摄入量（数量和来源）与成年人牙周状况在11年中的变化之间的关系。方法将参加芬兰2000年健康调查并在2004/2005年和/或2011年接受复查的30-82岁成年人纳入研究。在基线期，通过有效的食物频率问卷调查确定过去一年总淀粉和六类相关食物（马铃薯、油炸马铃薯、块根和块茎、面食、全麦和豆类）的消费量。2000年、2004/2005年和2011年的临床检查记录了牙周袋≥4毫米（NTPP）的牙齿数量。在混合效应负二项回归模型中检验了基线淀粉摄入量与11年NTPP变化之间的关系，并对协变量进行了调整。第 1、2 和 3 波的平均 NTPP 分别为 4.1 ± 5.6、6.3 ± 5.6 和 4.8 ± 5.9。基线淀粉摄入量（克/天或能量摄入百分比）与共变因素调整后的 NTPP 变化无关。结论本研究没有发现基线淀粉摄入量与牙周状况变化之间存在关联的证据。全谷物的基线摄入量与基线牙周状况的改善有关。

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