Pub Date : 2024-07-23DOI: 10.9734/jocamr/2024/v25i8555
U. P. Ise, T. Famojuro, Ambi Ibrahim Maman, Ponman Nanpon Samuel, Patience Duppe, M. Builders
This study evaluated the toxicity of a polyherbal Formulation (Ghana Cleanser®) on liver function markers of exposed albino rats. Thirty (30) male and female rats of the Wistar strain were randomly allotted into six (6) groups with n=5. 10.0 mL/kg distilled water was given to control groups 1 and 4. Polyherbal formulation doses of 374.0 mg/kg and 187.0 mg/kg were administered to groups 2-3 and 5-6, respectively. A modified Lorke's approach was used to compute acute toxicity. Animals were euthanized after 60 days under diethyl ether. Blood was collected for biochemical analyses through cardiac puncture. The liver was excised from each animal and was fixed in 10% buffered formaldehyde and prepared for histological assessment. LD50 of the polyherbal preparation was calculated as 3740 mg/kg (oral). The results indicated an appreciable increase (p<0.05) in ALT activity at 374.0 mg/kg in female rats; while there was no increase recorded at 187.0mg/kg in male rats. A significant increase in ALT activity was recorded at 374 mg/kg in male rats as well and increased AST activities were recorded at 187mg/kg in female rats. In the treated animals of both sexes, ALP activities were significantly elevated. Histopathology assessment of the hepatocytes showed no significant damage at 187 mg/kg in rats of both sexes when compared with their respective controls while some degrees of pathologies such as hepatocyte inflammation, hyperplasia, and congestion were recorded at 374 mg/kg in rats of both sexes. Results suggest caution on the long-term use of the polyherbal mixture due to its hepatotoxic potential.
{"title":"Sub-chronic Hepatotoxicity Assessment of Ghana Cleanser® in Exposed Wistar Rats","authors":"U. P. Ise, T. Famojuro, Ambi Ibrahim Maman, Ponman Nanpon Samuel, Patience Duppe, M. Builders","doi":"10.9734/jocamr/2024/v25i8555","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i8555","url":null,"abstract":"This study evaluated the toxicity of a polyherbal Formulation (Ghana Cleanser®) on liver function markers of exposed albino rats. Thirty (30) male and female rats of the Wistar strain were randomly allotted into six (6) groups with n=5. 10.0 mL/kg distilled water was given to control groups 1 and 4. Polyherbal formulation doses of 374.0 mg/kg and 187.0 mg/kg were administered to groups 2-3 and 5-6, respectively. A modified Lorke's approach was used to compute acute toxicity. Animals were euthanized after 60 days under diethyl ether. Blood was collected for biochemical analyses through cardiac puncture. The liver was excised from each animal and was fixed in 10% buffered formaldehyde and prepared for histological assessment. LD50 of the polyherbal preparation was calculated as 3740 mg/kg (oral). The results indicated an appreciable increase (p<0.05) in ALT activity at 374.0 mg/kg in female rats; while there was no increase recorded at 187.0mg/kg in male rats. A significant increase in ALT activity was recorded at 374 mg/kg in male rats as well and increased AST activities were recorded at 187mg/kg in female rats. In the treated animals of both sexes, ALP activities were significantly elevated. Histopathology assessment of the hepatocytes showed no significant damage at 187 mg/kg in rats of both sexes when compared with their respective controls while some degrees of pathologies such as hepatocyte inflammation, hyperplasia, and congestion were recorded at 374 mg/kg in rats of both sexes. Results suggest caution on the long-term use of the polyherbal mixture due to its hepatotoxic potential.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"112 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.9734/jocamr/2024/v25i7554
Agus Yudawijaya, Auxilia Briliana Shirley Londo, Patria Adri Wibhawa, Ganda Pariama, Christina Roseville Lasma Aritonang
Aims: To find out the profile of primary headache patients at the Tanjung Priok Community Health Center from January 2023 to December 2023. Study Design: This research is a type of descriptive research with a cross-sectional research design. Data was obtained through secondary data collection, namely medical record data at the Tanjung Priok Community Health Center from January to December 2023. Place and Duration of Study: This research was conducted at the Tanjung Priok Community Health Center in January 2024. Methodology: The population of this study were all patients with a primary working diagnosis of primary headache disease at the Tanjung Priok Community Health Center for the period January 2023 – December 2023. Primary headache patients at the Tanjung Priok Community Health Center were declared to have met the inclusion and exclusion criteria. The sampling technique that will be used is the Total Sampling technique, namely the number of samples is the same as the number of medical records that will be used in the research. Results: The results obtained from this study were that of the 125 patients diagnosed with primary headache, the most patients experienced tension-type headache, namely 93 patients (74.4%), and migraine with aura was the least experienced, namely 4 patients (3.2%); The gender that experienced primary headaches was women, namely 77 patients (61.6%), while men were 48 patients (38.4%); Primary headache sufferers with an age range of more than 30 years to 60 years are the age with the largest number of patients, namely 64 patients (51.2%), while those aged more than 60 years experience the least number of primary headaches, namely 6 patients (4.8%); Based on employment, the largest group of patients who did not work was 79 patients (63.2%); Based on the choice of therapy, the majority of primary headache patients were treated medically, namely 113 patients (90.4%). Conclusion: That still are many patients who experienced primary headaches at the Tanjung Priok Community Health Center for the period January 2023 to December 2023, including female patients with an age range of 30-60 years and unemployed. This is of course important for all stakeholders to pay attention to to develop appropriate service programs as an effort to prevent and treat primary headaches, which even though they are categorized as mild illnesses, can have an impact on various things, including a person's daily performance in activities.
{"title":"Profile of Primary Headache Patients at Tanjung Priok Health Center for the Period of January – December 2023","authors":"Agus Yudawijaya, Auxilia Briliana Shirley Londo, Patria Adri Wibhawa, Ganda Pariama, Christina Roseville Lasma Aritonang","doi":"10.9734/jocamr/2024/v25i7554","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7554","url":null,"abstract":"Aims: To find out the profile of primary headache patients at the Tanjung Priok Community Health Center from January 2023 to December 2023. \u0000Study Design: This research is a type of descriptive research with a cross-sectional research design. Data was obtained through secondary data collection, namely medical record data at the Tanjung Priok Community Health Center from January to December 2023. \u0000Place and Duration of Study: This research was conducted at the Tanjung Priok Community Health Center in January 2024. \u0000Methodology: The population of this study were all patients with a primary working diagnosis of primary headache disease at the Tanjung Priok Community Health Center for the period January 2023 – December 2023. Primary headache patients at the Tanjung Priok Community Health Center were declared to have met the inclusion and exclusion criteria. The sampling technique that will be used is the Total Sampling technique, namely the number of samples is the same as the number of medical records that will be used in the research. \u0000Results: The results obtained from this study were that of the 125 patients diagnosed with primary headache, the most patients experienced tension-type headache, namely 93 patients (74.4%), and migraine with aura was the least experienced, namely 4 patients (3.2%); The gender that experienced primary headaches was women, namely 77 patients (61.6%), while men were 48 patients (38.4%); Primary headache sufferers with an age range of more than 30 years to 60 years are the age with the largest number of patients, namely 64 patients (51.2%), while those aged more than 60 years experience the least number of primary headaches, namely 6 patients (4.8%); Based on employment, the largest group of patients who did not work was 79 patients (63.2%); Based on the choice of therapy, the majority of primary headache patients were treated medically, namely 113 patients (90.4%). \u0000Conclusion: That still are many patients who experienced primary headaches at the Tanjung Priok Community Health Center for the period January 2023 to December 2023, including female patients with an age range of 30-60 years and unemployed. This is of course important for all stakeholders to pay attention to to develop appropriate service programs as an effort to prevent and treat primary headaches, which even though they are categorized as mild illnesses, can have an impact on various things, including a person's daily performance in activities.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.9734/jocamr/2024/v25i7553
Esievo, K.B., Fidelis, S.A., Gegele, I.B., Owen-Obaseki, E., Ibrahim, J.A
Aim: The aim of this research is to investigate the pharmacognostic characteristics, antioxidant potential, and anticholinesterase activity of Piliostigma thonningii (Schum.) Milne-Redh. This study seeks to evaluate its potential applications for neuroprotection and cognitive health enhancement. Place and Duration of Study: This study was carried out in Nigeria by the Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu – Abuja, Nigeria between January 2024 and March 2024. Methodology: Physicochemical studies, including total Ash value and moisture content, were assessed using the powdered leaf sample. Leaf microscopy was conducted to examine the epidermal layer of the leaves. Anti-oxidant assays (Total phenol, total flavonoid and 2,2- diphenyl-1-picrylhydrazyl [DPPH] free radical scavenging activity), as well as acetylcholinesterase (AchE) inhibition assay was carried out on the methanolic leaf extract of the plant. Results: The powdered leaves of P. thonningii contained a total ash of 5.00% ± 0.00 and 7.74% ± 0.01 moisture. The alcohol- and water-soluble extractive values were 8.51% ± 0.24 and 9.77% ± 0.31, respectively. Leaf microscopic analysis showed the presence of polygonal cell walls, unicellular multiseriate trichomes, trichome base, xylem vessels, rosette-type calcium oxalate crystals, parenchyma, and collenchyma cells. The methanolic leaf extract exhibited antioxidant capacity, inhibiting DPPH in a dose-dependent manner, with total phenolics and flavonoids of 53.74(GAE) ± 1.59 and 42.51mg QE/g ± 0.38, respectively. The methanolic extract of P. thonningii in this study showed an AchE inhibition of between 5.89 % at 10 mg/ml to 16.56 % at 20 mg/ml Conclusion: The study reveals significant pharmacognostic characteristics, robust antioxidant potential, and notable anticholinesterase activity of P. thonniingii, suggesting its promising role in neuroprotection. These findings highlight its potential application in enhancing cognitive health and preventing neurodegenerative diseases.
{"title":"Exploring the Pharmacognostic Characteristics, Antioxidant Potential, and Anticholinesterase Activity of Piliostigma thonningii (Schum.) Milne-Redh.: Implications for Neuroprotection and Cognitive Health","authors":"Esievo, K.B., Fidelis, S.A., Gegele, I.B., Owen-Obaseki, E., Ibrahim, J.A","doi":"10.9734/jocamr/2024/v25i7553","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7553","url":null,"abstract":"Aim: The aim of this research is to investigate the pharmacognostic characteristics, antioxidant potential, and anticholinesterase activity of Piliostigma thonningii (Schum.) Milne-Redh. This study seeks to evaluate its potential applications for neuroprotection and cognitive health enhancement.\u0000Place and Duration of Study: This study was carried out in Nigeria by the Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu – Abuja, Nigeria between January 2024 and March 2024.\u0000Methodology: Physicochemical studies, including total Ash value and moisture content, were assessed using the powdered leaf sample. Leaf microscopy was conducted to examine the epidermal layer of the leaves. Anti-oxidant assays (Total phenol, total flavonoid and 2,2- diphenyl-1-picrylhydrazyl [DPPH] free radical scavenging activity), as well as acetylcholinesterase (AchE) inhibition assay was carried out on the methanolic leaf extract of the plant.\u0000Results: The powdered leaves of P. thonningii contained a total ash of 5.00% ± 0.00 and 7.74% ± 0.01 moisture. The alcohol- and water-soluble extractive values were 8.51% ± 0.24 and 9.77% ± 0.31, respectively. Leaf microscopic analysis showed the presence of polygonal cell walls, unicellular multiseriate trichomes, trichome base, xylem vessels, rosette-type calcium oxalate crystals, parenchyma, and collenchyma cells. The methanolic leaf extract exhibited antioxidant capacity, inhibiting DPPH in a dose-dependent manner, with total phenolics and flavonoids of 53.74(GAE) ± 1.59 and 42.51mg QE/g ± 0.38, respectively. The methanolic extract of P. thonningii in this study showed an AchE inhibition of between 5.89 % at 10 mg/ml to 16.56 % at 20 mg/ml\u0000Conclusion: The study reveals significant pharmacognostic characteristics, robust antioxidant potential, and notable anticholinesterase activity of P. thonniingii, suggesting its promising role in neuroprotection. These findings highlight its potential application in enhancing cognitive health and preventing neurodegenerative diseases.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.9734/jocamr/2024/v25i7547
V. P. Simarmata, Keswari Aji Patriawati
Aims: This research aims to determine the relationship between parents practicing Clean and Healthy Living Behavior (PHBS) and the incidence of stunting in toddlers aged 2-5 years in Cibungur Village, Sumedang Regency in 2023. Study Design: This research is an analytical observational study with a cross-sectional design. Place and Duration of Study: The research was carried out in Cibungur Village, Sumedang Regency, West Java in May 2023. Methodology: The sample in this study was 139 parents who had children aged 2-5 years in Cibungur Village, Sumedang Regency, West Java. The sampling technique used in this study was consecutive sampling, that is, all subjects who came and met the selection criteria were included in the study until the required number of subjects was met. A questionnaire instrument was used to obtain data on variables that influence (X1) parents' healthy hygiene behavior. The variable influenced by (Y) is the incidence of stunting in toddlers aged 2-5 years in Cibungur Village, Sumedang Regency. The data source is parents of toddlers aged 2-5 years in Cibungur Village, Sumedang. Results: The results of the correlation test of the 10 PHBS indicators studied with the incidence of stunting found a relationship between exclusive breastfeeding (p = 0.004) and the habit of washing hands with soap (p = 0.001) with the incidence of stunting while history of childbirth assisted by health personnel (p = 0.066), weighing toddler routine at posyandu (p=0.070), eradicating mosquito nests (p = 0.778), daily physical activity (p = 1.000), consumption of fruits and vegetables every day (p = 0.594), not smoking in the house (p = 0.877), use of clean water (p = 0.066) and use of healthy latrines (p = 0.066) were not associated with stunting. Conclusion: Of the ten indicators of a Clean and Healthy Lifestyle, it was concluded that only two of them were related to the incidence of stunting, namely the Exclusive Breastfeeding indicator and the Habit of Washing Hands with Soap indicator.
{"title":"A Descriptive Study on Stunting in Toddlers & Contributing Factors in Cibungur Village, Sumedang District, Indonesia","authors":"V. P. Simarmata, Keswari Aji Patriawati","doi":"10.9734/jocamr/2024/v25i7547","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7547","url":null,"abstract":"Aims: This research aims to determine the relationship between parents practicing Clean and Healthy Living Behavior (PHBS) and the incidence of stunting in toddlers aged 2-5 years in Cibungur Village, Sumedang Regency in 2023. \u0000Study Design: This research is an analytical observational study with a cross-sectional design. \u0000Place and Duration of Study: The research was carried out in Cibungur Village, Sumedang Regency, West Java in May 2023. \u0000Methodology: The sample in this study was 139 parents who had children aged 2-5 years in Cibungur Village, Sumedang Regency, West Java. The sampling technique used in this study was consecutive sampling, that is, all subjects who came and met the selection criteria were included in the study until the required number of subjects was met. A questionnaire instrument was used to obtain data on variables that influence (X1) parents' healthy hygiene behavior. The variable influenced by (Y) is the incidence of stunting in toddlers aged 2-5 years in Cibungur Village, Sumedang Regency. The data source is parents of toddlers aged 2-5 years in Cibungur Village, Sumedang. \u0000Results: The results of the correlation test of the 10 PHBS indicators studied with the incidence of stunting found a relationship between exclusive breastfeeding (p = 0.004) and the habit of washing hands with soap (p = 0.001) with the incidence of stunting while history of childbirth assisted by health personnel (p = 0.066), weighing toddler routine at posyandu (p=0.070), eradicating mosquito nests (p = 0.778), daily physical activity (p = 1.000), consumption of fruits and vegetables every day (p = 0.594), not smoking in the house (p = 0.877), use of clean water (p = 0.066) and use of healthy latrines (p = 0.066) were not associated with stunting. \u0000Conclusion: Of the ten indicators of a Clean and Healthy Lifestyle, it was concluded that only two of them were related to the incidence of stunting, namely the Exclusive Breastfeeding indicator and the Habit of Washing Hands with Soap indicator.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"35 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Acupuncture Readiness Attitude (ARA) is a crucial component within the realm of acupuncture therapy. While the response expectancy of acupuncture - the anticipation of treatment effectiveness - is significant, the ARA plays a pivotal role. The ARA encompasses a patient’s willingness, openness, and readiness for acupuncture treatment, which can profoundly impact treatment outcomes. By prioritizing the ARA, acupuncture practitioners can enhance patient receptivity and ultimately contribute to the evolution of this ancient healing practice. This paper highlights the importance of considering the historical context in the development of acupuncture and stresses the requirement for a dedicated evaluator capable of assessing the ARA using an informal screener developed by the authors.
针灸准备态度（ARA）是针灸疗法的重要组成部分。针灸的反应预期--即对治疗效果的预期--固然重要，但 ARA 也起着举足轻重的作用。ARA 包括患者对针灸治疗的意愿、开放性和准备程度，可对治疗效果产生深远影响。通过优先考虑 ARA，针灸医师可以提高患者的接受能力，并最终促进这一古老疗法的发展。本文强调了考虑针灸发展历史背景的重要性，并强调需要有专门的评估人员，能够使用作者开发的非正式筛选器评估 ARA。
{"title":"Acupuncture Readiness Attitude Scale (ARAS): An Informal Screener for Patient Suitability for Acupuncture Treatment","authors":"Guo-Hui Xie, Meng Kiat Tan, Jennifer Erin Camulli, Chin Aik Koh","doi":"10.9734/jocamr/2024/v25i7546","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7546","url":null,"abstract":"The Acupuncture Readiness Attitude (ARA) is a crucial component within the realm of acupuncture therapy. While the response expectancy of acupuncture - the anticipation of treatment effectiveness - is significant, the ARA plays a pivotal role. The ARA encompasses a patient’s willingness, openness, and readiness for acupuncture treatment, which can profoundly impact treatment outcomes. By prioritizing the ARA, acupuncture practitioners can enhance patient receptivity and ultimately contribute to the evolution of this ancient healing practice. This paper highlights the importance of considering the historical context in the development of acupuncture and stresses the requirement for a dedicated evaluator capable of assessing the ARA using an informal screener developed by the authors.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141347482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.9734/jocamr/2024/v25i7545
F. Suling, Anastacia Justine, Wiradi Suryanegara
Aims: This research aims to determine the factors that most cause the incidence of hypertension in outpatients at the Kramat Jati District Health Center, East Jakarta in 2024. Study design: Cross-Sectional Design Place and Duration of Study: This research was carried out at the Non-Communicable Diseases Polyclinic or Hypertension Polyclinic, Kramat Jati District Health Center, East Jakarta. Data collection took place for 2 weeks in February 2024. Methodology: The selected population is outpatients who have hypertension and are active as controls and non-hypertensive outpatients who visit the Kramat Jati District Health Center, East Jakarta. The selected samples were outpatients, specifically hypertensive patients at the Kramat Jati District Health Center, East Jakarta. Samples were collected using non-random accidental sampling technique and 101 research samples were obtained. Data Processing and Analysis using SPSS (Statistical Package for the Social Sciences) 29th version was used to view research results using univariate and bivariate analysis. Results: The results obtained showed that 81 respondents (80.2%) experienced hypertension. The dominant characteristics of hypertensive patients were found to be women (65.3%), aged 56-65 years (28.7%), patients who had a family history of hypertension (52.5%), patients who consumed ≥ 5 grams of sodium (70 .3%), patients who did physical activity (76.2%), and patients who did smoke (31.7%). The factors of age (p-value = 0.0001), history of hypertension (p-value = 0.046), sodium diet (p-value = 0.0001), and smoking (p-value = 0.039) are significantly related and most dominantly influence the incidence. Hypertension. The factors of gender (p-value = 0.410) and physical activity (p-value = 0.454) were not significantly related to increasing blood pressure. Conclusion: There is a significant relationship between factors that unmodified factors, namely age and family history of hypertension, with the incidence of hypertension at the Kramat Jati District Health Center, East Jakarta, and there is also a significant relationship between factors that can be changed, namely dietary sodium patterns and smoking activities, and the incidence of hypertension in Kramat Jati District Health Center, East Jakarta.
{"title":"Determinants of Hypertension in Outpatients: A Cross-Sectional Study at Kramat Jati Health Center, East Jakarta","authors":"F. Suling, Anastacia Justine, Wiradi Suryanegara","doi":"10.9734/jocamr/2024/v25i7545","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7545","url":null,"abstract":"Aims: This research aims to determine the factors that most cause the incidence of hypertension in outpatients at the Kramat Jati District Health Center, East Jakarta in 2024. \u0000Study design: Cross-Sectional Design \u0000Place and Duration of Study: This research was carried out at the Non-Communicable Diseases Polyclinic or Hypertension Polyclinic, Kramat Jati District Health Center, East Jakarta. Data collection took place for 2 weeks in February 2024. \u0000Methodology: The selected population is outpatients who have hypertension and are active as controls and non-hypertensive outpatients who visit the Kramat Jati District Health Center, East Jakarta. The selected samples were outpatients, specifically hypertensive patients at the Kramat Jati District Health Center, East Jakarta. Samples were collected using non-random accidental sampling technique and 101 research samples were obtained. Data Processing and Analysis using SPSS (Statistical Package for the Social Sciences) 29th version was used to view research results using univariate and bivariate analysis. \u0000Results: The results obtained showed that 81 respondents (80.2%) experienced hypertension. The dominant characteristics of hypertensive patients were found to be women (65.3%), aged 56-65 years (28.7%), patients who had a family history of hypertension (52.5%), patients who consumed ≥ 5 grams of sodium (70 .3%), patients who did physical activity (76.2%), and patients who did smoke (31.7%). The factors of age (p-value = 0.0001), history of hypertension (p-value = 0.046), sodium diet (p-value = 0.0001), and smoking (p-value = 0.039) are significantly related and most dominantly influence the incidence. Hypertension. The factors of gender (p-value = 0.410) and physical activity (p-value = 0.454) were not significantly related to increasing blood pressure. \u0000Conclusion: There is a significant relationship between factors that unmodified factors, namely age and family history of hypertension, with the incidence of hypertension at the Kramat Jati District Health Center, East Jakarta, and there is also a significant relationship between factors that can be changed, namely dietary sodium patterns and smoking activities, and the incidence of hypertension in Kramat Jati District Health Center, East Jakarta.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"50 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-08DOI: 10.9734/jocamr/2024/v25i7543
E. O. Ohanme, O. Iganga, C. Ofor, Uzochukwu Ofonakara, Amucheukwu Veronica Nwafor, C. Eze, K. E. Etu, B. N. Nwakelu, Chiazor Prince Unekwe
Both recurrent and spontaneous seizures are indications of epilepsy, a disorder of the brain. Around the world, as many as sixty-five million individuals could be influenced, and 80 percent of cases are found in low-income countries. Medicinal herbs are widely utilized to treat and manage epilepsy and convulsions due to their unique healing properties. Through greater research and clinical use, medicinal plants are gaining attention on a global scale because of their potent therapeutic effects and few adverse effects. The development of innovative plant-based antiepileptic/anticonvulsant medications has drawn a lot of interest from the pharmaceutical industry. This article provides an overview of the study on medicinal plants that have been demonstrated to have antiepileptic and anticonvulsant qualities. It provides pharmacological and molecular mechanism of action data for the crude extracts and related active ingredients evaluated in preclinical research for the treatment of epilepsy and convulsions, and it works as a guide for the development of future pertinent studies in this area. Articles about ethnopharmacological and antiepileptic studies on plants or natural products from the most recent and recent years were obtained from PubMed, Web of Science, and Scopus, among other sources, using keywords related to epilepsy, medicinal plants, natural products, etc. Many plant species are commonly utilized in Asian and African countries to treat epilepsy and convulsions. It has also been discovered that natural chemicals derived from these medicinal plants may possess antiepileptic and anticonvulsant qualities. These compounds can be broadly classified as terpenoids, alkaloids, coumarins, flavonoids, and saponins. The antiepileptic capabilities of plant extracts and their active ingredients can be classified according to their ability to affect the GABAergic and glutamatergic systems, act as antioxidants, exhibit anti-neuroinflammatory characteristics, and provide neuroprotection. Additionally, we highlight the potential use of various medicinal plants as a therapeutic intervention for refractory epilepsy, as they may be able to pharmacologically reduce epilepsy and cognitive impairment. The research highlights how herbal remedies used in traditional medicine are a great source of potential candidates for antiepileptic drugs. This demonstrates and validates the antiepileptic and anticonvulsant qualities of various therapeutic herbs, which could inspire further study. To fully comprehend the ideas of metabolic processes, toxicity, clinical trials, structural optimization, and change, further research is still necessary.
{"title":"Pharmacological Review of Plants and Natural Products with Antiepileptic Effects","authors":"E. O. Ohanme, O. Iganga, C. Ofor, Uzochukwu Ofonakara, Amucheukwu Veronica Nwafor, C. Eze, K. E. Etu, B. N. Nwakelu, Chiazor Prince Unekwe","doi":"10.9734/jocamr/2024/v25i7543","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7543","url":null,"abstract":"Both recurrent and spontaneous seizures are indications of epilepsy, a disorder of the brain. Around the world, as many as sixty-five million individuals could be influenced, and 80 percent of cases are found in low-income countries. Medicinal herbs are widely utilized to treat and manage epilepsy and convulsions due to their unique healing properties. Through greater research and clinical use, medicinal plants are gaining attention on a global scale because of their potent therapeutic effects and few adverse effects. The development of innovative plant-based antiepileptic/anticonvulsant medications has drawn a lot of interest from the pharmaceutical industry. This article provides an overview of the study on medicinal plants that have been demonstrated to have antiepileptic and anticonvulsant qualities. It provides pharmacological and molecular mechanism of action data for the crude extracts and related active ingredients evaluated in preclinical research for the treatment of epilepsy and convulsions, and it works as a guide for the development of future pertinent studies in this area. Articles about ethnopharmacological and antiepileptic studies on plants or natural products from the most recent and recent years were obtained from PubMed, Web of Science, and Scopus, among other sources, using keywords related to epilepsy, medicinal plants, natural products, etc. Many plant species are commonly utilized in Asian and African countries to treat epilepsy and convulsions. It has also been discovered that natural chemicals derived from these medicinal plants may possess antiepileptic and anticonvulsant qualities. These compounds can be broadly classified as terpenoids, alkaloids, coumarins, flavonoids, and saponins. The antiepileptic capabilities of plant extracts and their active ingredients can be classified according to their ability to affect the GABAergic and glutamatergic systems, act as antioxidants, exhibit anti-neuroinflammatory characteristics, and provide neuroprotection. Additionally, we highlight the potential use of various medicinal plants as a therapeutic intervention for refractory epilepsy, as they may be able to pharmacologically reduce epilepsy and cognitive impairment. The research highlights how herbal remedies used in traditional medicine are a great source of potential candidates for antiepileptic drugs. This demonstrates and validates the antiepileptic and anticonvulsant qualities of various therapeutic herbs, which could inspire further study. To fully comprehend the ideas of metabolic processes, toxicity, clinical trials, structural optimization, and change, further research is still necessary.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-08DOI: 10.9734/jocamr/2024/v25i7544
M. Njie, A. Timimi, P. M. Mulendelé, H. Charif, M. Bouziane, M. Haboub, S. Arous, G. Benouna, A. Drighil, R. Habbal
Background: APECED or multiple endocrine deficiency autoimmune candidiasis syndrome is a rare disease characterized by the manifestation of autoimmune endocrinopathies in a peculiar sequence during infancy. The clinical diagnosis of APECED requires the presence of at least two of these three major components: Chronic mucocutaneus candidiasis, hypoparathyroidism and or primary adrenal insufficiency. Genetic testing is necessary for precise identification in certain instances, particularly those presenting with atypical or subtle symptoms. Clinical Presentation: we report a rare clinical manifestation of APECED syndrome in a 7-year-old girl from a Moroccan origin, unique child born in a 2nd consanguineous marriage, was admitted initially for cardiac tamponade revealing the underlying disease. Patient’s assessment after pericardiocentesis confirmed hypoparathyroidism disease and undiagnosed chronic onychomycosis of the nails of her right hand. A genetic test was carried out after multidisciplinary discussion between cardiologists and endocrinologists which tested positive for a mutation in the AIRE (21q22.3) gene responsible for APECED syndrome. Treatment was based on symptomatic treatment of acute pericarditis according to the guidelines of European Society of Cardiology on the management of pericarditis with a good clinical outcome associated with oral calcium supplementation and levothyroxine. Conclusion: APECED syndrome is an exceptional disease both in terms of its frequency and its pathophysiological mechanisms and requires a multidisciplinary approach. The management of APECED syndrome involves the management of the various diseases. Patients must be monitored regularly to detect the appearance of other pathological elements of the syndrome.
{"title":"Cardiac Tamponade Revealing an “APECED Syndrome”, an Unsual Manifestation in a 7-Year-Old Moroccan Girl: A Case Report","authors":"M. Njie, A. Timimi, P. M. Mulendelé, H. Charif, M. Bouziane, M. Haboub, S. Arous, G. Benouna, A. Drighil, R. Habbal","doi":"10.9734/jocamr/2024/v25i7544","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7544","url":null,"abstract":"Background: APECED or multiple endocrine deficiency autoimmune candidiasis syndrome is a rare disease characterized by the manifestation of autoimmune endocrinopathies in a peculiar sequence during infancy. The clinical diagnosis of APECED requires the presence of at least two of these three major components: Chronic mucocutaneus candidiasis, hypoparathyroidism and or primary adrenal insufficiency. Genetic testing is necessary for precise identification in certain instances, particularly those presenting with atypical or subtle symptoms. \u0000Clinical Presentation: we report a rare clinical manifestation of APECED syndrome in a 7-year-old girl from a Moroccan origin, unique child born in a 2nd consanguineous marriage, was admitted initially for cardiac tamponade revealing the underlying disease. Patient’s assessment after pericardiocentesis confirmed hypoparathyroidism disease and undiagnosed chronic onychomycosis of the nails of her right hand. A genetic test was carried out after multidisciplinary discussion between cardiologists and endocrinologists which tested positive for a mutation in the AIRE (21q22.3) gene responsible for APECED syndrome. Treatment was based on symptomatic treatment of acute pericarditis according to the guidelines of European Society of Cardiology on the management of pericarditis with a good clinical outcome associated with oral calcium supplementation and levothyroxine. \u0000Conclusion: APECED syndrome is an exceptional disease both in terms of its frequency and its pathophysiological mechanisms and requires a multidisciplinary approach. The management of APECED syndrome involves the management of the various diseases. Patients must be monitored regularly to detect the appearance of other pathological elements of the syndrome.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: The purpose of this study was to see how telerehabilitation affected post-viral tiredness following COVID-19. Study Design: Narrative Review. Materials and Methods: Various computerised data bases were used to conduct a structured Literature search. PubMed, Google Scholar, Pedro, American Physical Therapy Association (APTA), World Health Organization (WHO), World Confederation Physical Therapy (WCPT), Medscape, Research-gate Embase, American Physical Therapy Association (APTA), World Health Organization (WHO), World Confederation Physical Therapy (WCPT), Medscape, Research-gate Embase Clinical trials, randomised controlled trials, cross-sectional studies, cohort studies, and literature reviews were all part of the search strategy. The search was restricted to English literature alone. Result: A total of 75 items were found in various electronic databases. Based on inclusion and exclusion criteria, 57 articles containing actual substance were shortlisted. Telerehabilitation in post-viral fatigue syndrome following covid 19 had a good effect on the patients, according to the study. It helps individuals with Post-Viral Fatigue Syndrome increase their breathing rate, physical strength, and overall function. Conclusion: This narrative review of the literature discovered that physiotherapy therapies, particularly Telerehabilitation, have a good effect in post-viral fatigue following covid19. Telerehabilitation has a greater impact on reducing the symptoms of post viral fatigue syndrome patients and will aid in their recovery. The things taught in Telerehabilitation also assist a lot, and the exercise improves the cardiovascular system by increasing HR (heart rate), breathing rate, body temperature, and blood pressure (Blood pressure).
{"title":"Exploring Impact of Telerehabilitation in Post Viral Fatigue Syndrome Following COVID-19: A Narrative Review of Literature","authors":"Nilofar Rasheed, Jyoti Yadav, Bhawna Sharma, Farha Parveen","doi":"10.9734/jocamr/2024/v25i7542","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i7542","url":null,"abstract":"Aims: The purpose of this study was to see how telerehabilitation affected post-viral tiredness following COVID-19. \u0000Study Design: Narrative Review. \u0000Materials and Methods: Various computerised data bases were used to conduct a structured Literature search. PubMed, Google Scholar, Pedro, American Physical Therapy Association (APTA), World Health Organization (WHO), World Confederation Physical Therapy (WCPT), Medscape, Research-gate Embase, American Physical Therapy Association (APTA), World Health Organization (WHO), World Confederation Physical Therapy (WCPT), Medscape, Research-gate Embase Clinical trials, randomised controlled trials, cross-sectional studies, cohort studies, and literature reviews were all part of the search strategy. The search was restricted to English literature alone. \u0000Result: A total of 75 items were found in various electronic databases. Based on inclusion and exclusion criteria, 57 articles containing actual substance were shortlisted. Telerehabilitation in post-viral fatigue syndrome following covid 19 had a good effect on the patients, according to the study. It helps individuals with Post-Viral Fatigue Syndrome increase their breathing rate, physical strength, and overall function. \u0000Conclusion: This narrative review of the literature discovered that physiotherapy therapies, particularly Telerehabilitation, have a good effect in post-viral fatigue following covid19. Telerehabilitation has a greater impact on reducing the symptoms of post viral fatigue syndrome patients and will aid in their recovery. The things taught in Telerehabilitation also assist a lot, and the exercise improves the cardiovascular system by increasing HR (heart rate), breathing rate, body temperature, and blood pressure (Blood pressure).","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.9734/jocamr/2024/v25i6541
Daisy Ahluwalia, N. Khunger, Abhishek Lachyan, Kuchana Prathibha, Abhay Goyal
Background: Acanthosis Nigricans (AN) is a dermatologic manifestation characterized by hyperpigmentation and thickening of the skin, commonly observed in body folds. While traditionally considered a cutaneous marker of insulin resistance, recent studies have hinted at broader metabolic implications associated with AN. Understanding the intricate connections between AN and various metabolic parameters is crucial for comprehensive patient care and management. Purpose: The primary objective of this study was to investigate the metabolic associations of Acanthosis Nigricans, with a specific emphasis on its correlation with obesity, insulin resistance (IR), and metabolic syndrome (METS). The aim was to provide insights into the interplay between AN severity and metabolic health indicators, particularly focusing on the 18-40 age group and the impact on the neck area. Methods: The study employed a cross-sectional design, involving a diverse sample of participants within the 18-40 age range. Data collection included detailed clinical assessments, anthropometric measurements, biochemical analyses, and ultrasound evaluations. Statistical analyses explored associations between AN severity, obesity, insulin resistance, metabolic syndrome, and other relevant metabolic parameters. Results: The study found a high prevalence of AN in the 18-40 age group, primarily affecting the neck area. Significant associations were observed between AN and metabolic derangements such as obesity, hypertension, hyperinsulinemia, and type 2 diabetes. The prevalence of metabolic syndrome in AN cases was 20.0%, with ultrasound changes like fatty liver and polycystic ovary syndrome noted in 13.3% of the participants. Conclusion: The findings highlight the importance of recognizing the broader impact of AN on metabolic health beyond its traditional association with insulin resistance. The intricate interplay between AN and various metabolic parameters, including abnormal insulin levels, BMI, ultrasound findings, and metabolic syndrome, underscores the complexity of this dermatologic manifestation. It is crucial to shift the focus from AN severity alone to a comprehensive understanding of its multifaceted connections with systemic metabolic health.
背景：黑棘皮病（AN）是一种皮肤病，以色素沉着和皮肤增厚为特征，常见于身体褶皱处。虽然传统上认为黑棘皮病是胰岛素抵抗的皮肤标志，但最近的研究暗示了与黑棘皮病相关的更广泛的代谢影响。了解 AN 与各种代谢参数之间错综复杂的联系对于患者的全面护理和管理至关重要。目的：本研究的主要目的是调查黑棘皮病的代谢相关性，特别强调其与肥胖、胰岛素抵抗（IR）和代谢综合征（METS）的相关性。其目的是深入了解黑棘皮病的严重程度与代谢健康指标之间的相互作用，尤其侧重于 18-40 岁年龄组以及对颈部的影响。研究方法研究采用横断面设计，涉及 18-40 岁年龄段的不同参与者样本。数据收集包括详细的临床评估、人体测量、生化分析和超声波评估。统计分析探讨了AN严重程度、肥胖、胰岛素抵抗、代谢综合征和其他相关代谢参数之间的关联。研究结果研究发现，18-40 岁年龄组的 AN 患病率较高，主要累及颈部。研究发现，AN 与肥胖、高血压、高胰岛素血症和 2 型糖尿病等代谢紊乱之间存在显著关联。AN病例中代谢综合征的发病率为20.0%，13.3%的参与者出现脂肪肝和多囊卵巢综合征等超声变化。结论研究结果强调，除了传统的胰岛素抵抗外，还必须认识到AN对代谢健康的广泛影响。AN 与各种代谢参数（包括胰岛素水平异常、体重指数、超声波检查结果和代谢综合征）之间错综复杂的相互作用凸显了这种皮肤病表现的复杂性。关键是要将关注点从 AN 的严重程度转移到全面了解 AN 与全身代谢健康的多方面联系上来。
{"title":"The Correlation between Severity of Acanthosis Nigricans and Metabolic Syndrome","authors":"Daisy Ahluwalia, N. Khunger, Abhishek Lachyan, Kuchana Prathibha, Abhay Goyal","doi":"10.9734/jocamr/2024/v25i6541","DOIUrl":"https://doi.org/10.9734/jocamr/2024/v25i6541","url":null,"abstract":"Background: Acanthosis Nigricans (AN) is a dermatologic manifestation characterized by hyperpigmentation and thickening of the skin, commonly observed in body folds. While traditionally considered a cutaneous marker of insulin resistance, recent studies have hinted at broader metabolic implications associated with AN. Understanding the intricate connections between AN and various metabolic parameters is crucial for comprehensive patient care and management. \u0000Purpose: The primary objective of this study was to investigate the metabolic associations of Acanthosis Nigricans, with a specific emphasis on its correlation with obesity, insulin resistance (IR), and metabolic syndrome (METS). The aim was to provide insights into the interplay between AN severity and metabolic health indicators, particularly focusing on the 18-40 age group and the impact on the neck area. \u0000Methods: The study employed a cross-sectional design, involving a diverse sample of participants within the 18-40 age range. Data collection included detailed clinical assessments, anthropometric measurements, biochemical analyses, and ultrasound evaluations. Statistical analyses explored associations between AN severity, obesity, insulin resistance, metabolic syndrome, and other relevant metabolic parameters. \u0000Results: The study found a high prevalence of AN in the 18-40 age group, primarily affecting the neck area. Significant associations were observed between AN and metabolic derangements such as obesity, hypertension, hyperinsulinemia, and type 2 diabetes. The prevalence of metabolic syndrome in AN cases was 20.0%, with ultrasound changes like fatty liver and polycystic ovary syndrome noted in 13.3% of the participants. \u0000Conclusion: The findings highlight the importance of recognizing the broader impact of AN on metabolic health beyond its traditional association with insulin resistance. The intricate interplay between AN and various metabolic parameters, including abnormal insulin levels, BMI, ultrasound findings, and metabolic syndrome, underscores the complexity of this dermatologic manifestation. It is crucial to shift the focus from AN severity alone to a comprehensive understanding of its multifaceted connections with systemic metabolic health.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"210 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141375972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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