Aim: This study evaluated the Impact of Distance Online Laughter Yoga (DOLY) on Work Stress, Work Anxiety, aloneness & Work Depression feelings in Corporate Employees Who Worked from Home During the COVID Pandemic
Methods: A pilot randomized controlled trial (RCT) was conducted to assess the effects of distance online laughter yoga (DOLY) on work depression, work anxiety, work stress, and aloneness among adults. Thirty-two participants were randomly assigned to receive DOLY twice weekly for four weeks, while twenty-nine participants were assigned to a control group that received no intervention. Data were collected using the Depression Anxiety Stress Scale (DASS-21) and the De Jong Gierveld Loneliness Scale (DGLS) at the beginning of the study and at week four.
Randomization Process : Using this website (http://www.randomizer.org)
Results: The online laughter yoga (DOLY) intervention resulted in a statistically significant reduction in work depression symptoms (DASS-21: t(59) = -2.31, p < 0.05). The mean work depression scores for the intervention and control groups at pre-test were 10.0 and 12.0, respectively. After the DOLY intervention, the mean work depression scores for the intervention and control groups were 8.0 and 12.0, respectively.
There were no statistically significant differences between the intervention and control groups in work anxiety, work stress, or work loneliness symptoms.
Conclusion: The findings of this study suggest that DOLY may be an effective intervention for reducing work depression symptoms. However, further research is needed to determine whether DOLY is effective in reducing other work-related stressors, such as anxiety, stress, and loneliness.
目的:本研究评估远程在线笑瑜伽(DOLY)对工作压力、工作焦虑、孤独感和情绪的影响。COVID大流行期间在家工作的企业员工的工作抑郁感
方法:采用随机对照试验(RCT)评估远程在线笑瑜伽(DOLY)对成人工作抑郁、工作焦虑、工作压力和孤独感的影响。32名参与者被随机分配到每周接受两次DOLY治疗，持续四周，而29名参与者被分配到不接受干预的对照组。在研究开始时和第四周使用抑郁焦虑压力量表(DASS-21)和De Jong Gierveld孤独量表(DGLS)收集数据。
随机化过程:使用本网站(http://www.randomizer.org)
结果:在线笑瑜伽(DOLY)干预导致工作抑郁症状显著减少(DASS-21: t(59) = -2.31, p <0.05)。干预组和对照组的工作抑郁前测平均分分别为10.0分和12.0分。经DOLY干预后，干预组和对照组的平均工作抑郁得分分别为8.0和12.0。
干预组与对照组在工作焦虑、工作压力、工作孤独症状方面无统计学差异。
结论:本研究结果提示DOLY可能是减轻工作抑郁症状的有效干预措施。然而，需要进一步的研究来确定DOLY是否有效地减少其他与工作相关的压力源，如焦虑、压力和孤独。
{"title":"The Impact of Distance Online Laughter Yoga (DOLY) on Work Stress, Work Anxiety, Aloneness & Work Depression Feeling on Corporate Employees Who Worked from Home during the COVID Pandemic","authors":"Harish Rawat, Saloni Bisht, Abhishek Gupta, Irfan Elahi, Anupam Kumar Sachan, Challa Krishnaveer Abhishek Ram Kukkurah Vighnahartayyapodu","doi":"10.9734/jocamr/2023/v24i2497","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i2497","url":null,"abstract":"Aim: This study evaluated the Impact of Distance Online Laughter Yoga (DOLY) on Work Stress, Work Anxiety, aloneness & Work Depression feelings in Corporate Employees Who Worked from Home During the COVID Pandemic
 Methods: A pilot randomized controlled trial (RCT) was conducted to assess the effects of distance online laughter yoga (DOLY) on work depression, work anxiety, work stress, and aloneness among adults. Thirty-two participants were randomly assigned to receive DOLY twice weekly for four weeks, while twenty-nine participants were assigned to a control group that received no intervention. Data were collected using the Depression Anxiety Stress Scale (DASS-21) and the De Jong Gierveld Loneliness Scale (DGLS) at the beginning of the study and at week four.
 Randomization Process : Using this website (http://www.randomizer.org)
 Results: The online laughter yoga (DOLY) intervention resulted in a statistically significant reduction in work depression symptoms (DASS-21: t(59) = -2.31, p < 0.05). The mean work depression scores for the intervention and control groups at pre-test were 10.0 and 12.0, respectively. After the DOLY intervention, the mean work depression scores for the intervention and control groups were 8.0 and 12.0, respectively.
 There were no statistically significant differences between the intervention and control groups in work anxiety, work stress, or work loneliness symptoms.
 Conclusion: The findings of this study suggest that DOLY may be an effective intervention for reducing work depression symptoms. However, further research is needed to determine whether DOLY is effective in reducing other work-related stressors, such as anxiety, stress, and loneliness.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.9734/jocamr/2023/v24i2496
Debasish Sahoo, Neha Jain, S. K. Meena
Objective: Sub-acute stroke is a common condition that often results in upper limb impairments. This systematic review aims to evaluate the effectiveness of combined modified constraint-induced movement therapy (mCIMT) and mirror therapy on upper limb performance in patients with sub-acute stroke. The review also aimed to identify gaps in the existing literature and provide recommendations for future research.
Methods: A comprehensive search was conducted on electronic databases, including PubMed, Google Scholar, ResearchGate, and AJOT. Studies published between 2010 and 2022 were included in the review. Qualitative studies that investigated the effects of combined mCIMT and mirror therapy in patients with sub-acute stroke were included. The PRISMA flow diagram was utilized to track the study selection process. Two independent reviewers assessed the eligibility of the studies and extracted relevant data using predefined criteria.
Results: Out of the initial 250 articles, 10 studies met the inclusion criteria and were included in the review. Published between 2010 and 2022, these studies utilized various research designs, including quasi-experimental studies, randomized controlled trials, and pilot studies. The majority of the studies were conducted in hospital settings and involved patients with sub-acute stroke. The findings of the included studies suggest that combined mCIMT and mirror therapy have positive effects on hand functions, motor recovery, functional outcomes, and activities of daily living in patients with sub-acute stroke.
Conclusion: This systematic review provides evidence supporting the effectiveness of combined mCIMT and mirror therapy in improving upper limb performance in patients with sub-acute stroke. These interventions have the potential to enhance motor recovery and functional outcomes in this population. However, further research is needed to determine the optimal duration, intensity, and timing of these interventions. Standardized outcome measures and larger sample sizes should be considered in future studies to strengthen the evidence base.
{"title":"Enhancing Upper Limb Performance in Sub-acute Stroke Patients: A Systematic Review of Combined Modified Constraint-Induced Movement Therapy and Mirror Therapy Interventions","authors":"Debasish Sahoo, Neha Jain, S. K. Meena","doi":"10.9734/jocamr/2023/v24i2496","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i2496","url":null,"abstract":"Objective: Sub-acute stroke is a common condition that often results in upper limb impairments. This systematic review aims to evaluate the effectiveness of combined modified constraint-induced movement therapy (mCIMT) and mirror therapy on upper limb performance in patients with sub-acute stroke. The review also aimed to identify gaps in the existing literature and provide recommendations for future research.
 Methods: A comprehensive search was conducted on electronic databases, including PubMed, Google Scholar, ResearchGate, and AJOT. Studies published between 2010 and 2022 were included in the review. Qualitative studies that investigated the effects of combined mCIMT and mirror therapy in patients with sub-acute stroke were included. The PRISMA flow diagram was utilized to track the study selection process. Two independent reviewers assessed the eligibility of the studies and extracted relevant data using predefined criteria.
 Results: Out of the initial 250 articles, 10 studies met the inclusion criteria and were included in the review. Published between 2010 and 2022, these studies utilized various research designs, including quasi-experimental studies, randomized controlled trials, and pilot studies. The majority of the studies were conducted in hospital settings and involved patients with sub-acute stroke. The findings of the included studies suggest that combined mCIMT and mirror therapy have positive effects on hand functions, motor recovery, functional outcomes, and activities of daily living in patients with sub-acute stroke.
 Conclusion: This systematic review provides evidence supporting the effectiveness of combined mCIMT and mirror therapy in improving upper limb performance in patients with sub-acute stroke. These interventions have the potential to enhance motor recovery and functional outcomes in this population. However, further research is needed to determine the optimal duration, intensity, and timing of these interventions. Standardized outcome measures and larger sample sizes should be considered in future studies to strengthen the evidence base.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Triumfetta cordifolia is a terrestrial plant of the Tiliaceae family used traditionally for the treatment of many diseases. Different parts are traditionally used for the treatment of diseases that cause pain and inflammation. This study aims to evaluate the antinociceptive and anti-inflammatory activities of the methanol/dichloromethane extract of T. cordifolia roots in animal models.
Methodology: Phytochemical screening and the toxicity study of methanol/dichloromethane extract of Triumfetta cordifolia roots were performed. Antinociceptive activity was evaluated using acetic acid and formalin tests. In vitro anti-inflammatory activity was evaluated using the bovine serum albumin (BSA) denaturation method and In vivo on carrageenan-induced oedema. The extract was given orally at doses of 50, 100 and 150 mg/kg of body weight.
Results: The phytochemical analysis revealed the presence of alkaloids, saponins, flavonoïds, polyphenols, reducing sugars, tannins, coumarins and steroids. No signs of toxicity were observed after 14 days experiment. Regarding antinociceptive activity, Triumfetta cordifolia (200 mg/kg) has decreased significantly (P ˂ 0.0001) the number of abdominal contortions and also significantly inhibited the formalin-induced neurogenic pain at the dose of 50 mg/kg body weight. In anti-inflammatory tests, the extract inhibited oedema (P˂ 0,001) at 50mg/kg at the fourth hour and also protected the serum albumin bovine denaturation (P <0.05) at a concentration of 50 μg/ml.
Conclusion: The results obtained indicate that the methanol/dichloromethane extract is without acute toxicity and has peripheral and central analgesic properties, as well as anti-inflammatory properties In vivo and In vitro.
{"title":"Antinociceptive and Anti-inflammatory Properties of Triumfetta cordifolia A. Rich. (Tiliaceae) Root Methanol/Dichloromethane Extract","authors":"Chameni Nkouankam Maeva Jenna, Nguemfo Edwige Laure, Hzounda Jean Baptiste, Ngene Jean Pierre, Nguemnang Tchatchouang Russelle Camelie, Nsegbe Annick Christianne, Kuinze Kojap Augustine, Mbogbe Nadia Elise, Songue Sylvie Pascale, Sone Enone Bertin, Francois Eya’ane Meva","doi":"10.9734/jocamr/2023/v24i2495","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i2495","url":null,"abstract":"Objective: Triumfetta cordifolia is a terrestrial plant of the Tiliaceae family used traditionally for the treatment of many diseases. Different parts are traditionally used for the treatment of diseases that cause pain and inflammation. This study aims to evaluate the antinociceptive and anti-inflammatory activities of the methanol/dichloromethane extract of T. cordifolia roots in animal models.
 Methodology: Phytochemical screening and the toxicity study of methanol/dichloromethane extract of Triumfetta cordifolia roots were performed. Antinociceptive activity was evaluated using acetic acid and formalin tests. In vitro anti-inflammatory activity was evaluated using the bovine serum albumin (BSA) denaturation method and In vivo on carrageenan-induced oedema. The extract was given orally at doses of 50, 100 and 150 mg/kg of body weight.
 Results: The phytochemical analysis revealed the presence of alkaloids, saponins, flavonoïds, polyphenols, reducing sugars, tannins, coumarins and steroids. No signs of toxicity were observed after 14 days experiment. Regarding antinociceptive activity, Triumfetta cordifolia (200 mg/kg) has decreased significantly (P ˂ 0.0001) the number of abdominal contortions and also significantly inhibited the formalin-induced neurogenic pain at the dose of 50 mg/kg body weight. In anti-inflammatory tests, the extract inhibited oedema (P˂ 0,001) at 50mg/kg at the fourth hour and also protected the serum albumin bovine denaturation (P <0.05) at a concentration of 50 μg/ml.
 Conclusion: The results obtained indicate that the methanol/dichloromethane extract is without acute toxicity and has peripheral and central analgesic properties, as well as anti-inflammatory properties In vivo and In vitro.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.9734/jocamr/2023/v24i2494
None Weerasekara S., None Waratenne P. R., None Chandrasekara N. V., None Wijewickrama E. S., None Sunil-Chandra N. P.
At present, Chronic kidney disease (CKD) has emerged as a significant global health concern even in Sri Lanka. The statistical data regarding the increased incidence and prevalence rate of CKD have already proven that there is still no identification of a permanent cure or solution instead of renal replacement therapy for disease management. This remains a tremendous challenge for Western and Āyurveda medical systems. Although the Āyurveda medical system is well nourished by its own concepts such as Dhātu sāratā (tissue excellence), Deha prakṛti (body constitution), which can potentially contribute to the prevention and management of CKD, their clinical applicability appears to be limited. Therefore, this study was planned to assess the status of Dhātu sāratā (the level of tissue excellence) and its association with Deha prakṛti (body constitution) in patients with CKD – Western Province, Sri Lanka. This is a prospective observational case – control study. University Nephrology Clinic at the National Hospital, Sri Lanka and the Renal Clinic at Bandaranaike Memorial Āyurveda Research Institute, Nawinna, Sri Lanka. 113 patients with a diagnosis of CKD and 122 healthy volunteers residing in the Western Province were enrolled in the study. Dhātu sāratā status of Rasa to Sattva was assessed using a standardized and validated questionnaire and ĀyuSoft software was used to assess the type of Deha prakṛti of the research participants. Data analysis was done by using Microsoft Excel 2007 version and appropriate statistical software. The study results revealed that a majority between 43 – 50 % of CKD patients exhibited a predominance of Madhyama sāra status (moderate level of tissue excellence) for Rasa, Rakta and Māṃsa dhātu. A considerable percentage (over 60%) of patients displayed Avara sāra status (inferior or lower level of tissue excellence) in their subsequent dhātu (including Sattva), commencing from Asthi. Compared to the CKD patients, the number of healthy individuals/ controls with Pravara sāra status (superior level of tissue excellence) of each dhātu and Sattva is substantially high. None of the healthy individuals had Avara sāra status of Dhātu nor Sattva. Furthermore, it was observed that the mean percentage scores of all dhātu (commencing from Rasa to Śukra dhātu) and Sattva sāratā significantly differed according to CKD stages under a 5% level of significance. It was also observed that the status of Dhātu commencing from Rasa to Śukra dhātu and Sattva sāratā was significantly associated with the Deha prakṛti types i.e., Vāta, Pitta and Kapha pradhāna prakṛti in CKD patients – Western Province, Sri Lanka, under a 5 % level of significance.It can be concluded that Dhātu sāratā status including Sattva depends on the type of Deha prakṛti in CKD patients and Sāra status of each Dhātu including Sattva declines from Pravara sāra to Avara sāra as the disease progresses. In addition, the CKD patients with Kapha pradhāna prakṛti type can be conside
{"title":"Status of Dhātu sāratā (the Level of Tissue Excellence) and its Association with Deha prakṛti (Body Constitution) in Patients with Chronic Kidney Disease","authors":"None Weerasekara S., None Waratenne P. R., None Chandrasekara N. V., None Wijewickrama E. S., None Sunil-Chandra N. P.","doi":"10.9734/jocamr/2023/v24i2494","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i2494","url":null,"abstract":"At present, Chronic kidney disease (CKD) has emerged as a significant global health concern even in Sri Lanka. The statistical data regarding the increased incidence and prevalence rate of CKD have already proven that there is still no identification of a permanent cure or solution instead of renal replacement therapy for disease management. This remains a tremendous challenge for Western and Āyurveda medical systems. Although the Āyurveda medical system is well nourished by its own concepts such as Dhātu sāratā (tissue excellence), Deha prakṛti (body constitution), which can potentially contribute to the prevention and management of CKD, their clinical applicability appears to be limited. Therefore, this study was planned to assess the status of Dhātu sāratā (the level of tissue excellence) and its association with Deha prakṛti (body constitution) in patients with CKD – Western Province, Sri Lanka. This is a prospective observational case – control study. University Nephrology Clinic at the National Hospital, Sri Lanka and the Renal Clinic at Bandaranaike Memorial Āyurveda Research Institute, Nawinna, Sri Lanka. 113 patients with a diagnosis of CKD and 122 healthy volunteers residing in the Western Province were enrolled in the study. Dhātu sāratā status of Rasa to Sattva was assessed using a standardized and validated questionnaire and ĀyuSoft software was used to assess the type of Deha prakṛti of the research participants. Data analysis was done by using Microsoft Excel 2007 version and appropriate statistical software. The study results revealed that a majority between 43 – 50 % of CKD patients exhibited a predominance of Madhyama sāra status (moderate level of tissue excellence) for Rasa, Rakta and Māṃsa dhātu. A considerable percentage (over 60%) of patients displayed Avara sāra status (inferior or lower level of tissue excellence) in their subsequent dhātu (including Sattva), commencing from Asthi. Compared to the CKD patients, the number of healthy individuals/ controls with Pravara sāra status (superior level of tissue excellence) of each dhātu and Sattva is substantially high. None of the healthy individuals had Avara sāra status of Dhātu nor Sattva. Furthermore, it was observed that the mean percentage scores of all dhātu (commencing from Rasa to Śukra dhātu) and Sattva sāratā significantly differed according to CKD stages under a 5% level of significance. It was also observed that the status of Dhātu commencing from Rasa to Śukra dhātu and Sattva sāratā was significantly associated with the Deha prakṛti types i.e., Vāta, Pitta and Kapha pradhāna prakṛti in CKD patients – Western Province, Sri Lanka, under a 5 % level of significance.It can be concluded that Dhātu sāratā status including Sattva depends on the type of Deha prakṛti in CKD patients and Sāra status of each Dhātu including Sattva declines from Pravara sāra to Avara sāra as the disease progresses. In addition, the CKD patients with Kapha pradhāna prakṛti type can be conside","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134944621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.9734/jocamr/2023/v24i1493
Brendan C. Iloka, Christopher O. Igbokwe, Williams E. Ike, Gail B. Mahady, Bolanle A. Adeniyi
Background: The urgent need for new and novel antibacterial chemotherapy to combat the worrisome emergence of antimicrobial resistance necessitated the exploration of medicinal plants such as Funtumia elastica. This study was designed to evaluate the antibacterial activity, acute and sub-acute toxicity studies of Funtumia elastica which is used in the ethnomedical treatment of infections.
Methods: The leaves and stem bark of F. elastica were collected, pulverized, extracted using soxhlet extractor and evaluated phytochemically. Antibacterial activities and Minimum Inhibitory Concentrations (MIC) of the crude extracts were investigated on clinical isolates using agar well diffusion. Bioactive fractions of the dichloromethane extract were obtained through column chromatography and thin layer chromatography. Acute and subacute toxicity studies were evaluated on the dichloromethane extract (DCM) using female Swiss albino mice.
Results: The leaves contain tannins, flavonoids, alkaloids, steroids, saponins, and glycosides while the stem contains tannins and steroids. The hexane extracts lack activities while DCM and ethylacetate extracts of F. elastica were found to have some degree of activities on tested clinical isolates. Bioactivity guided fractionation of the DCM extract yielded only fraction 2 been active on the clinical isolates at 3.5625mg/mL. There were no signs of acute toxicity at the maximum dose of 5000mg/kg body weight. Biochemical parameters showed no significant changes in the liver enzymes. This infers that the extract might not have any negative impact on the liver with regards to metabolism.
Conclusion: The moderate antibacterial activities of Funtumia elastica extracts justified its ethnomedicinal uses and potential to furnish new antimicrobials.
{"title":"Evaluation of the Antibacterial Activity and Toxicity Properties of Funtumia elastica (Preuss) Stapf. (TSN 30176), Used in Traditional Medicine in Nigeria","authors":"Brendan C. Iloka, Christopher O. Igbokwe, Williams E. Ike, Gail B. Mahady, Bolanle A. Adeniyi","doi":"10.9734/jocamr/2023/v24i1493","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i1493","url":null,"abstract":"Background: The urgent need for new and novel antibacterial chemotherapy to combat the worrisome emergence of antimicrobial resistance necessitated the exploration of medicinal plants such as Funtumia elastica. This study was designed to evaluate the antibacterial activity, acute and sub-acute toxicity studies of Funtumia elastica which is used in the ethnomedical treatment of infections.
 Methods: The leaves and stem bark of F. elastica were collected, pulverized, extracted using soxhlet extractor and evaluated phytochemically. Antibacterial activities and Minimum Inhibitory Concentrations (MIC) of the crude extracts were investigated on clinical isolates using agar well diffusion. Bioactive fractions of the dichloromethane extract were obtained through column chromatography and thin layer chromatography. Acute and subacute toxicity studies were evaluated on the dichloromethane extract (DCM) using female Swiss albino mice.
 Results: The leaves contain tannins, flavonoids, alkaloids, steroids, saponins, and glycosides while the stem contains tannins and steroids. The hexane extracts lack activities while DCM and ethylacetate extracts of F. elastica were found to have some degree of activities on tested clinical isolates. Bioactivity guided fractionation of the DCM extract yielded only fraction 2 been active on the clinical isolates at 3.5625mg/mL. There were no signs of acute toxicity at the maximum dose of 5000mg/kg body weight. Biochemical parameters showed no significant changes in the liver enzymes. This infers that the extract might not have any negative impact on the liver with regards to metabolism.
 Conclusion: The moderate antibacterial activities of Funtumia elastica extracts justified its ethnomedicinal uses and potential to furnish new antimicrobials.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.9734/jocamr/2023/v24i1492
Bello Usman, Mohammed Usman Sajo, Musa Kalim Adam, Peter Anjili Mshelia, Ibrahim Bulama, Kyari Abba Sanda
Objective: Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. This study was designed to investigate the role of antioxidants in the treatment of induced TBI in albino rats.
Methodology: Adult albino rats were induced with TBI by the weight-drop method. Rats were grouped into three groups of eight rats each. Group I served as a traumatized-treated group (TT), Group II served as a non-traumatized, non-treated group (TNT), and group III served as normal control group. The treatment group received 67.5 mg/kg of vitamin E (VE). Treatment started 30 minutes after the trauma and continued for 21 days. The antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA) in serum tissue were assayed to evaluate oxidative stress (OS).
Results: The treated group showed a significant (p< 0.05) increase in the activities of antioxidant enzymes (SOD, CAT GPx) and a significant (p<0.05) decrease in the concentration of MDA compared to the TNT group.
Conclusion: Conclusively, these promising results suggest that the use of antioxidant VE may be a useful neuroprotective strategy in the treatment of TBI.
{"title":"Effect of Vitamin E on Serum MDA and Antioxidant Enzymes in Traumatic Brain Injury-Induced Rats","authors":"Bello Usman, Mohammed Usman Sajo, Musa Kalim Adam, Peter Anjili Mshelia, Ibrahim Bulama, Kyari Abba Sanda","doi":"10.9734/jocamr/2023/v24i1492","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i1492","url":null,"abstract":"Objective: Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. This study was designed to investigate the role of antioxidants in the treatment of induced TBI in albino rats.
 Methodology: Adult albino rats were induced with TBI by the weight-drop method. Rats were grouped into three groups of eight rats each. Group I served as a traumatized-treated group (TT), Group II served as a non-traumatized, non-treated group (TNT), and group III served as normal control group. The treatment group received 67.5 mg/kg of vitamin E (VE). Treatment started 30 minutes after the trauma and continued for 21 days. The antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA) in serum tissue were assayed to evaluate oxidative stress (OS). 
 Results: The treated group showed a significant (p< 0.05) increase in the activities of antioxidant enzymes (SOD, CAT GPx) and a significant (p<0.05) decrease in the concentration of MDA compared to the TNT group.
 Conclusion: Conclusively, these promising results suggest that the use of antioxidant VE may be a useful neuroprotective strategy in the treatment of TBI.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.9734/jocamr/2023/v24i1490
Faith Onyedikachi Ogar, Victor Tamunotonye Ibubeleye, Precious Ojo Uahomo, Nwibana Barisuka Kofii
Background: Green tea is rich in flavonoids and catechins, compounds reported to have antioxidant, anti-inflammatory, and anticancer properties. However, there is a need to evaluate the effects of green tea on vital organs like the liver. This study aimed to investigate the effects of Camellia sinensis on markers of liver function, and liver histology in Wistar rats.
Methods: Forty-eight adult male Wistar rats were divided into four equal groups and orally administered 250mg/kg, 500mg/kg and 1000mg/kg of Camellia sinensis extract or 1ml of distilled water for up to 28 days. AST, ALT, ALP, TP, ALB, TB, and CB levels were measured at various time points. Effect on liver histology was also assessed using haematoxylin and eosin staining. Results: Camellia sinensis had varying effects on biomarkers of liver injury in a dose-dependent manner. Higher doses (500mg/kg and 1000mg/kg) of Camellia sinensis led to significant increases in AST, ALT, and ALP levels when consumed for up to 21 days. TP and ALB levels were not significantly altered. TB levels significantly increased in the highest dose group while CB levels did not significantly change at any time point studied. Also, higher doses of Camellia sinensis were associated with the development of fatty liver and mild inflammation from the histology. Conclusion: Camellia sinensis extract at low dose may not be harmful to the liver, however, the potential toxicity of green tea on the liver (at higher doses) should be further studied. Moderate use of green tea is therefore, recommended to ensure its safe and beneficial effects on liver health.
{"title":"Evaluation of the Effects of Green Tea (Camellia sinensis) on Markers of Liver Function and Liver Histology in Wistar Rats","authors":"Faith Onyedikachi Ogar, Victor Tamunotonye Ibubeleye, Precious Ojo Uahomo, Nwibana Barisuka Kofii","doi":"10.9734/jocamr/2023/v24i1490","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i1490","url":null,"abstract":"Background: Green tea is rich in flavonoids and catechins, compounds reported to have antioxidant, anti-inflammatory, and anticancer properties. However, there is a need to evaluate the effects of green tea on vital organs like the liver. This study aimed to investigate the effects of Camellia sinensis on markers of liver function, and liver histology in Wistar rats.
 Methods: Forty-eight adult male Wistar rats were divided into four equal groups and orally administered 250mg/kg, 500mg/kg and 1000mg/kg of Camellia sinensis extract or 1ml of distilled water for up to 28 days. AST, ALT, ALP, TP, ALB, TB, and CB levels were measured at various time points. Effect on liver histology was also assessed using haematoxylin and eosin staining. Results: Camellia sinensis had varying effects on biomarkers of liver injury in a dose-dependent manner. Higher doses (500mg/kg and 1000mg/kg) of Camellia sinensis led to significant increases in AST, ALT, and ALP levels when consumed for up to 21 days. TP and ALB levels were not significantly altered. TB levels significantly increased in the highest dose group while CB levels did not significantly change at any time point studied. Also, higher doses of Camellia sinensis were associated with the development of fatty liver and mild inflammation from the histology. Conclusion: Camellia sinensis extract at low dose may not be harmful to the liver, however, the potential toxicity of green tea on the liver (at higher doses) should be further studied. Moderate use of green tea is therefore, recommended to ensure its safe and beneficial effects on liver health.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-25DOI: 10.9734/jocamr/2023/v24i1489
R. S. Ajani, John Chinedu Obianke
Objective: Lead is a highly toxic, non-biodegradable heavy metal usually found in the environment largely as a pollutant of water, soil or air. Chronic lead exposure has adverse effects on human health. Lycopersicon esculentum has many phytochemicals that may ameliorate organ injury due to lead toxicity in humans. This study answered the question “Is aqueous extract of Lycopersicon esculentum (tomato) beneficent to lead toxicity induced liver injury?” Methodology: The study had five groups with fifteen animals each. The control was group CN. The lead toxicity group (PbT) had 30 mg/kg/day of lead acetate crystals, the concomitant extract group (CE) had concurrent administration of lead acetate and aqueous extract of L. esculentum (at 400 mg/kg). The post lead toxicity low dose extract. (PLE) had sequential administration of lead acetate and aq. extract L. esculentum (at 400 mg/kg). The post lead toxicity high dose extract. (PHE) had sequential administration of lead acetate and aq. extract L. esculentum (at 800 mg/kg). Both the lead acetate and extract were administered orally for twenty one days. At specific periods, blood samples were collected for biochemical analyses and organs harvested for histopathological evaluation. Result: The total plasma protein levels of the extract groups (CE, PLE and PHE) were significantly higher than that of the PbT group. The PbT group had markedly elevated plasma liver enzymes. Oxidative stress was only evident in the PbT group but not in the extract groups as suggested by the significantly depressed anti-oxidant activities and elevated lipid peroxidation. A cystic lesion was observed in one of the liver specimens from the PbT group. Histopathological findings included fatty infiltration of the liver in the PbT group and presence of multinucleated hepatocytes in the extract groups. The latter feature suggested the ability of aqueous extract of L. esculentum to ameliorate the lead (Pb) toxicity induced liver damage. Conclusion: Concurrent and post-exposure administration of aqueous extract of tomato fruit (L. esculentum) mollified the liver injury caused by lead toxicity.
{"title":"Mollification of Lead Induced Liver Injury by Lycopersicon esculentum (Tomato) Extract","authors":"R. S. Ajani, John Chinedu Obianke","doi":"10.9734/jocamr/2023/v24i1489","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i1489","url":null,"abstract":"Objective: Lead is a highly toxic, non-biodegradable heavy metal usually found in the environment largely as a pollutant of water, soil or air. Chronic lead exposure has adverse effects on human health. Lycopersicon esculentum has many phytochemicals that may ameliorate organ injury due to lead toxicity in humans. This study answered the question “Is aqueous extract of Lycopersicon esculentum (tomato) beneficent to lead toxicity induced liver injury?” \u0000Methodology: The study had five groups with fifteen animals each. The control was group CN. The lead toxicity group (PbT) had 30 mg/kg/day of lead acetate crystals, the concomitant extract group (CE) had concurrent administration of lead acetate and aqueous extract of L. esculentum (at 400 mg/kg). The post lead toxicity low dose extract. (PLE) had sequential administration of lead acetate and aq. extract L. esculentum (at 400 mg/kg). The post lead toxicity high dose extract. (PHE) had sequential administration of lead acetate and aq. extract L. esculentum (at 800 mg/kg). Both the lead acetate and extract were administered orally for twenty one days. At specific periods, blood samples were collected for biochemical analyses and organs harvested for histopathological evaluation. \u0000Result: The total plasma protein levels of the extract groups (CE, PLE and PHE) were significantly higher than that of the PbT group. The PbT group had markedly elevated plasma liver enzymes. Oxidative stress was only evident in the PbT group but not in the extract groups as suggested by the significantly depressed anti-oxidant activities and elevated lipid peroxidation. A cystic lesion was observed in one of the liver specimens from the PbT group. Histopathological findings included fatty infiltration of the liver in the PbT group and presence of multinucleated hepatocytes in the extract groups. The latter feature suggested the ability of aqueous extract of L. esculentum to ameliorate the lead (Pb) toxicity induced liver damage. \u0000Conclusion: Concurrent and post-exposure administration of aqueous extract of tomato fruit (L. esculentum) mollified the liver injury caused by lead toxicity.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89350680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.9734/jocamr/2023/v24i1488
Nia Reviani, Wiradi Suryanegara, Abitmer Gultom
The first thousand days of life is a golden period from 0-2 years which is a critical period in brain growth because there is a rapid increase in the development of cells in the brain that are very vulnerable to damage. If, at this time, the child is suffering from malnutrition, it cannot be guaranteed that further development will proceed normally. This study aims to describe knowledge about the importance of of the first 1000 days of life in women of childbearing age (15-49 years) in 2021. This research is a descriptive study with purposive sampling and obtained a total sample of 115 respondents. The results showed that the description of the knowledge of women of childbearing age about the meaning of of the first 1000 days of life showed that most women of childbearing age had moderate knowledge of 64 people (56%), knowledge of the of the first 1000 days of life program showed that most women of childbearing age had high knowledge of 44 people (38%), and knowledge about nutrition in of the first 1000 days of life shows that most women of childbearing age have moderate knowledge of 72 people (63%). Based on the results of the study, the description of knowledge about the importance of the first 1000 days of life in women of childbearing age (15-49 years) regarding of the first 1000 days of life program is included in the medium category, regarding the understanding of of the first 1000 days of life is included in the high category, and regarding nutrition in of the first 1000 days of life is included in the medium category.
{"title":"Overview of Knowledge about the Importance of the First 1000 Days of Life In Indonesian Women of Reproductive Age (15 - 49 Years) in 2021","authors":"Nia Reviani, Wiradi Suryanegara, Abitmer Gultom","doi":"10.9734/jocamr/2023/v24i1488","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v24i1488","url":null,"abstract":"The first thousand days of life is a golden period from 0-2 years which is a critical period in brain growth because there is a rapid increase in the development of cells in the brain that are very vulnerable to damage. If, at this time, the child is suffering from malnutrition, it cannot be guaranteed that further development will proceed normally. This study aims to describe knowledge about the importance of of the first 1000 days of life in women of childbearing age (15-49 years) in 2021. This research is a descriptive study with purposive sampling and obtained a total sample of 115 respondents. The results showed that the description of the knowledge of women of childbearing age about the meaning of of the first 1000 days of life showed that most women of childbearing age had moderate knowledge of 64 people (56%), knowledge of the of the first 1000 days of life program showed that most women of childbearing age had high knowledge of 44 people (38%), and knowledge about nutrition in of the first 1000 days of life shows that most women of childbearing age have moderate knowledge of 72 people (63%). Based on the results of the study, the description of knowledge about the importance of the first 1000 days of life in women of childbearing age (15-49 years) regarding of the first 1000 days of life program is included in the medium category, regarding the understanding of of the first 1000 days of life is included in the high category, and regarding nutrition in of the first 1000 days of life is included in the medium category.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81640751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-18DOI: 10.9734/jocamr/2023/v23i4487
J. Ibrahim, I. B. Gegele, Omotayo T. Hamzat, H. Egharevba, Adeola I. Jegede, O. Kunle, O. Adigwe
Aim: This study explores and documents obstacles faced by Traditional Medicine Practitioners (TMPs) in Nigeria. Traditional Medicine (TM) plays a vital role in the healthcare systems of low- and middle-income countries, yet it encounters numerous challenges. Place and Duration of Study: This study was carried out in Nigeria by the Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu – Abuja, Nigeria between December 2021 and January 2022. Methodology: A survey was conducted among Nigerian TMPs using a semi-structured questionnaire to gain insights into their challenges and potential solutions. TMPs were recruited nationwide using purposive and convenient sampling, and descriptive statistics were used to present data gathered. Results: The majority of TMP respondents (67%) were male, with 48% holding graduate degrees and 11% having doctorates. Regarding practice, 87% of TMPs maintain patient records, and 88% keep medicinal recipe records. Most TMPs (81%) engage in general practice alongside other forms. Collaboration willingness was expressed by 89% towards fellow practitioners, 95% towards research institutes, and 89% towards individual researchers. Challenges identified by TMPs include a lack of cooperation from orthodox doctors (25%), absence of standardized products (19%), inadequate policies (19%), and disorganization among TMPs (15%). Product registration revealed that 81% of TMPs had unregistered products, with 49% citing high registration costs and 21% lacking knowledge about the process. Specific challenges mentioned were insufficient financial resources (48%) and a need for training (30%). Conclusion: It is crucial for stakeholders to collaborate and review policies to address the highlighted challenges and gaps as found in this study.
{"title":"Practice and Perception of Traditional Medicine Practitioners towards Challenges Facing Traditional Medicine Practice in Nigeria: A Pilot Study","authors":"J. Ibrahim, I. B. Gegele, Omotayo T. Hamzat, H. Egharevba, Adeola I. Jegede, O. Kunle, O. Adigwe","doi":"10.9734/jocamr/2023/v23i4487","DOIUrl":"https://doi.org/10.9734/jocamr/2023/v23i4487","url":null,"abstract":"Aim: This study explores and documents obstacles faced by Traditional Medicine Practitioners (TMPs) in Nigeria. Traditional Medicine (TM) plays a vital role in the healthcare systems of low- and middle-income countries, yet it encounters numerous challenges. \u0000Place and Duration of Study: This study was carried out in Nigeria by the Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu – Abuja, Nigeria between December 2021 and January 2022. \u0000Methodology: A survey was conducted among Nigerian TMPs using a semi-structured questionnaire to gain insights into their challenges and potential solutions. TMPs were recruited nationwide using purposive and convenient sampling, and descriptive statistics were used to present data gathered. \u0000Results: The majority of TMP respondents (67%) were male, with 48% holding graduate degrees and 11% having doctorates. Regarding practice, 87% of TMPs maintain patient records, and 88% keep medicinal recipe records. Most TMPs (81%) engage in general practice alongside other forms. Collaboration willingness was expressed by 89% towards fellow practitioners, 95% towards research institutes, and 89% towards individual researchers. Challenges identified by TMPs include a lack of cooperation from orthodox doctors (25%), absence of standardized products (19%), inadequate policies (19%), and disorganization among TMPs (15%). Product registration revealed that 81% of TMPs had unregistered products, with 49% citing high registration costs and 21% lacking knowledge about the process. Specific challenges mentioned were insufficient financial resources (48%) and a need for training (30%). \u0000Conclusion: It is crucial for stakeholders to collaborate and review policies to address the highlighted challenges and gaps as found in this study.","PeriodicalId":15398,"journal":{"name":"Journal of Complementary and Alternative Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90476531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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