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CD1a-positive dendritic cell-enriched pigmented purpuric dermatosis in association with dyslipidemia cd1a阳性树突状细胞富集的色素性紫癜性皮肤病与血脂异常相关
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_85_20
T. Hinojosa, D. Lewis, M. Duvic, C. Torres‐Cabala
Indeterminate cells (ICs) are dendritic cells (DCs) that share the histologic features of Langerhans cells and macrophages but lack Birbeck granules. It remains unclear whether IC histiocytosis is a separate disease entity or a reactive process. We report the case of a male with an 8-year history of dyslipidemia who developed extensive pigmented purpuric papules. Laboratory studies revealed peripheral monocytosis (8.2%), and two skin biopsies showed a dermal lichenoid lymphohistiocytic infiltrate composed of CD4+ T cells and CD8+ T cells and CD68+CD163+CD1a+Langerin histiocytes. PD-1/PD-L1+T cells were present in the dermis. Our case may help in understanding the pathogenesis of IC histiocytosis, and we hypothesize that expression of CD1a+ dermal DCs and T-cell dysfunction is a reactive process to dyslipidemia.
不确定细胞是树突状细胞,具有朗格汉斯细胞和巨噬细胞的组织学特征,但缺乏Birbeck颗粒。目前尚不清楚IC组织细胞增多症是一种单独的疾病实体还是一种反应性过程。我们报告的情况下,男性与8年的历史血脂异常谁发展广泛的色素紫癜丘疹。实验室检查显示外周单核细胞增多(8.2%),两次皮肤活检显示真皮地衣样淋巴组织细胞浸润,由CD4+ T细胞、CD8+ T细胞和CD68+CD163+CD1a+Langerin组织细胞组成。真皮中存在PD-1/PD-L1+T细胞。我们的病例可能有助于理解IC组织细胞增多症的发病机制,我们假设CD1a+真皮dc的表达和t细胞功能障碍是血脂异常的反应过程。
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引用次数: 1
Autologous platelet-rich fibrin membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers: A prospective study 自体富血小板纤维蛋白膜作为伤口敷料治疗慢性不愈合腿溃疡:一项前瞻性研究
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_80_20
Amina Asfiya, Sacchidanand Sarvajnamurthy, F. Shariff, Leelavathy Budamakuntala
Background: Chronic nonhealing ulcers of the lower extremity are a cause of morbidity and mortality. The various treatment options available are limited and unsatisfactory. Promoting wound healing with an autologous platelet membrane could be a safe, easy, and inexpensive modality. Purpose: To assess an autologous platelet-rich fibrin (PRF) membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers. Methods: A prospective study enrolled 30 patients with chronic nonhealing leg ulcers. Autologous PRF was applied weekly for 6 weeks. At each visit, the ulcer healing was assessed with wound measurements and photographs. The treatment outcome was defined as a percentage in a change of area and volume of the ulcer at the end of the study period. Results: Thirty patients with chronic nonhealing leg ulcers were treated for 6 weeks. 100% improvement in area of the ulcer was seen in 43% ulcers. The mean percentage of improvement in area of the ulcer was 72%. The mean percentage of improvement in volume of the ulcer was 77%. The mean duration of healing was 5 weeks. Conclusion: This study was limited by the lack of a control group. Autologous PRF may be useful for the treatment of chronic nonhealing leg ulcers which can be done on an outpatient basis with minimum adverse effects.
背景:下肢慢性不愈合溃疡是导致发病率和死亡率的原因之一。可供选择的各种治疗方法是有限的,而且不能令人满意。自体血小板膜促进伤口愈合是一种安全、简便、廉价的方法。目的:评估一种自体富血小板纤维蛋白(PRF)膜作为伤口敷料治疗慢性不愈合的腿部溃疡。方法:一项前瞻性研究纳入了30例慢性无法愈合的腿部溃疡患者。每周应用自体PRF,连续6周。每次就诊时,通过伤口测量和照片评估溃疡愈合情况。治疗结果被定义为研究期结束时溃疡面积和体积变化的百分比。结果:30例慢性下肢溃疡患者治疗6周。43%的溃疡面积改善100%。溃疡面积改善的平均百分比为72%。溃疡体积改善的平均百分比为77%。平均愈合时间为5周。结论:本研究因缺乏对照组而受到限制。自体PRF可用于治疗慢性不愈合的腿部溃疡,可在门诊进行,副作用最小。
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引用次数: 0
Seborrheic keratosis-like changes in epidermal inclusion cyst: An unusual feature in a usual entity 表皮包涵囊肿的脂溢性角化样改变:在正常实体中不寻常的特征
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_110_21
S. Palo, C. Gargade
A 58-year-old male presented with an asymptomatic, slowly growing, cystic and mobile swelling on the left leg calf of 6 months duration. Fine-needle aspiration cytology was suggestive of epidermal inclusion cyst. Histopathological examination revealed seborrheic keratosis-like changes in the cyst wall comprising of marked acanthosis, papillomatosis, pseudohorn cysts, squamous eddies, and clumps of keratohyalin granules. This is a very rare variant of epidermal inclusion cyst, possibly induced by infection with human papillomavirus.
58岁男性,左腿小腿无症状,缓慢生长,囊性和移动性肿胀,持续6个月。细针穿刺细胞学提示表皮包涵性囊肿。组织病理学检查显示囊肿壁有脂流性角化样改变,包括明显的棘层增生、乳头状瘤、假角囊肿、鳞状漩涡和角质透明素颗粒团块。这是一种非常罕见的表皮包涵性囊肿,可能由人乳头瘤病毒感染引起。
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引用次数: 0
Linezolid-induced black hairy tongue: A case report and review of literature 利奈唑胺致黑毛舌1例报告及文献复习
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_1_22
M. Siddiqui, M. Adil, S. Amin, Kritika Xess
Black hairy tongue is an asymptomatic and benign condition presenting with black-to-brownish discoloration of the dorsum of the tongue with elongated filiform papillae. Several medications, particularly antibiotics, are implicated in its causation. Xerostomia, abnormal desquamation of the tongue, use of oxidizing mouthwashes, excessive intake of nicotine, coffee, and tea, and immunosuppressive states predispose to the development of this condition. Herein, we describe a case of a young female who developed black hairy tongue within 5 days of linezolid intake. The discoloration disappeared after 7 days of stopping the drug. We also summarize the various reports of black hairy tongue due to linezolid in a tabular form. We aim to highlight the importance of medication history in the identification of this uncommon condition. We also emphasize identifying risk factors for this condition and educating the patients about them.
黑毛舌是一种无症状的良性疾病,表现为舌背呈黑色至褐色变色,有细长的丝状乳头。几种药物,特别是抗生素,与其病因有关。口干、舌头异常脱屑、使用氧化性漱口水、过量摄入尼古丁、咖啡和茶以及免疫抑制状态均易导致此病的发生。在这里,我们描述了一个年轻的女性谁发展黑毛舌5天内利奈唑胺摄入的情况。停药7天后变色消失。我们还以表格形式总结了利奈唑胺引起的黑毛舌的各种报告。我们的目的是强调用药史在鉴别这种罕见疾病中的重要性。我们还强调识别这种情况的危险因素并对患者进行相关教育。
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引用次数: 0
Allergens in corticosteroid vehicles in Saudi Arabia 沙特阿拉伯皮质类固醇车辆中的过敏原
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_26_22
M. Alharbi, S. Almutairi, Maisa A Alfalah
Background: Both the active steroid compounds and vehicle ingredients of the topical corticosteroid products can cause allergic contact dermatitis. Purpose: The objective of the current study was to assess the presence of allergens in topical corticosteroid vehicles used in Saudi Arabia. Methods: Package inserts of topical corticosteroid products available through February 2022 were reviewed independently by two dermatologists. Topical corticosteroids were excluded if they were not approved by the Saudi Food and Drug Authority. Results: Out of 79 products examined, 49 (62%) were included in the study. Out of the 49 products, 29 (59%) had one or more allergens (a total of 38 allergens). Three topical corticosteroids were responsible for more than 80% of all allergens. These included mometasone furoate (n = 12), clobetasol propionate (n = 7), and betamethasone valerate (n = 5). The most frequent allergens were propylene glycol (66%), parabens (16%), sorbitan (13%), and lanolin (5%). Formaldehyde(s), methylchloro-isothiazolinone, and methyl-isothiazolinone were not detected in any product. Approximately 48% of the products with allergens were creams, 41% were ointments, and 10% were lotions. With two exceptions, there were no statistically significant differences in the overall presence of allergens by the type, formulation, and concentration of topical corticosteroid products. Conclusion: Almost 60% of topical corticosteroid products widely used in dermatologic clinics in Saudi Arabia had one or more vehicle allergens. Since the best treatment for contact allergy is avoidance, dermatologists should be aware of vehicle allergens in topical corticosteroids and consider the use of allergen-free products.
背景:活性类固醇化合物和外用皮质类固醇产品的载体成分均可引起过敏性接触性皮炎。目的:本研究的目的是评估在沙特阿拉伯使用的外用皮质类固醇车辆中是否存在过敏原。方法:两位皮肤科医生独立审查了截至2022年2月的外用皮质类固醇产品的说明书。如果外用皮质类固醇未经沙特食品和药物管理局批准,则被排除在外。结果:在检测的79种产品中,49种(62%)被纳入研究。在49种产品中,29种(59%)含有一种或多种过敏原(总共38种过敏原)。三种外用皮质类固醇占所有过敏原的80%以上。这些过敏原包括糠酸莫米松(n = 12)、丙酸氯倍他索(n = 7)和戊酸倍他米松(n = 5)。最常见的过敏原是丙二醇(66%)、对羟基苯甲酸酯(16%)、山梨醇(13%)和羊毛脂(5%)。在任何产品中均未检测到甲醛、甲基氯异噻唑啉酮和甲基异噻唑啉酮。大约48%含有过敏原的产品是面霜,41%是软膏,10%是乳液。除了两个例外,在过敏原的总体存在方面,外用皮质类固醇产品的类型、配方和浓度没有统计学上的显著差异。结论:在沙特阿拉伯皮肤病诊所广泛使用的近60%的外用皮质类固醇产品有一个或多个车辆过敏原。由于接触性过敏的最佳治疗是避免,皮肤科医生应该意识到外用皮质类固醇中的车辆过敏原,并考虑使用不含过敏原的产品。
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引用次数: 0
Saudi adolescent present with new-onset vitiligo post-COVID-19 vaccination: Case report 沙特青少年在covid -19疫苗接种后出现新发白癜风:病例报告
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_35_22
Abdullah Alnaim, Amnah Al-Mulhim, Mohammed Al-Momen, Lenah Shaikh
Coronavirus disease of 2019 (COVID-19) is a relatively new pandemic; the first reported case was in late 2019, and the first vaccine was given in December 2020. To this date, multiple side effects have been reported with COVID-19 vaccines. Nonetheless, autoimmune (AI) diseases with the COVID-19 vaccine have rarely been associated. We described herein a case of sudden onset of vitiligo occurring after the first dose of the COVID-19 vaccine. To date, there are less than 10 reported cases of vitiligo post-COVID-19 vaccine. This report aims to recognize AI disease presentation with vaccines, specifically COVID-19.
2019年冠状病毒病(COVID-19)是一种相对较新的大流行;第一例报告病例发生在2019年底,第一批疫苗于2020年12月接种。迄今为止,已报告了COVID-19疫苗的多种副作用。尽管如此,很少将自身免疫性疾病与COVID-19疫苗联系起来。我们在此描述了一例在首次接种COVID-19疫苗后突然发作的白癜风。迄今为止,报告的covid -19疫苗接种后白癜风病例不到10例。本报告旨在通过疫苗确认人工智能疾病的表现,特别是COVID-19。
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引用次数: 1
Topical immunotherapy for alopecia areata: A successful diphenylcyclopropenone protocol 局部免疫治疗斑秃:一个成功的二苯环丙烯方案
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_21_22
Melika Motamedi, Kush Bapujib, N. Dhaliwal
Alopecia areata (AA) is an autoimmune disorder that involves the destruction of anagenic hair follicles, resulting in non-scarring patchy hair loss. The patient presented in the following case had not seen improvement by use of conventional treatments and was started on topical immunotherapy, diphenylcyclopropenone (DPCP). This agent is commonly left as a last resort due to its constant need for follow-up, clinician-required administration, and risk of adverse effects. The following case presents a titration schedule using DPCP, resulting in minimal adverse effects and dramatic improvement in hair regeneration.
斑秃(AA)是一种自身免疫性疾病,涉及到对毛囊的破坏,导致无疤痕的斑状脱发。在以下病例中,患者没有看到使用常规治疗的改善,并开始局部免疫治疗,二苯环丙烯(DPCP)。这种药物通常作为最后的手段,因为它需要持续的随访,临床要求的给药,以及不良反应的风险。以下病例介绍了使用DPCP的滴定计划,导致最小的不良反应和显著改善头发再生。
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引用次数: 0
A 3-year-old girl with old face appearance: Case report 3岁女童面容老旧1例报告
Pub Date : 2022-07-01 DOI: 10.4103/jdds.jdds_51_22
Hamad Ayed Alfahaad
Hutchinson–Gilford Progeria Syndrome (HGPS) is a genetic disorder. Patients who suffer from this disorder show premature aging and a “plucked-bird” appearance on the face. This case reports a 3-year-old female, who manifested the symptoms of HGPS. The patient has a large head and eyes, receded jaws, a narrow nose, protruded forehead, decreased eyebrows and eyelash hair, stunted growth, and severe wrinkles. A genetic test was conducted to confirm the existence of the disease. The case is reported due to its rarity.
哈钦森-吉尔福德早衰综合征(HGPS)是一种遗传性疾病。患有这种疾病的患者表现为过早衰老,脸上出现“拔毛鸟”的样子。本病例报告一名3岁女性,她表现出HGPS的症状。患者头大,眼大,下颚后缩,鼻子窄,前额突出,眉毛和睫毛减少,生长发育迟缓,皱纹严重。进行了基因测试以证实这种疾病的存在。这一病例因罕见而被报道。
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引用次数: 0
Cavernous hemangioma resembling lymphangioma circumscriptum: The central role of dermoscope in diagnosis 海绵状血管瘤:皮肤镜在诊断中的核心作用
Pub Date : 2022-01-01 DOI: 10.4103/jdds.jdds_144_20
K. Djawad
Vascular tumors and malformations are often called “angiomas.” Cavernous hemangiomas are more commonly found in adolescents, often on the face and rarely on the extremities. Surgery may be pursued for cosmesis in cases of cutaneous lesions that do not involute. A 12-year-old girl presented with a lump on her right knee 4 years ago. Initially, the lump was flat and appeared like a bluish bruise but then slowly enlarged. There were no complaints of itching, pain, and other discomfort. Physical examination showed a 3.2 cm × 2.1 cm mobile violaceous tumor composed of dark red or blue-black vesicles in the right knee, clinically resembling lymphangioma circumscriptum. Dermoscopic examination showed a pattern composed of central dark, red-blue lacunae, white structures, and a peripheral brownish homogeneous area, which was consistent for cavernous hemangioma. The patient underwent biopsy excision and the diagnosis was confirmed through histopathological examination.
血管肿瘤和畸形通常被称为“血管瘤”。海绵状血管瘤更常见于青少年,通常在面部,很少在四肢。如果皮肤病变不扩大,可以进行外科手术进行美容。一个12岁的女孩四年前右膝有个肿块。最初,肿块是扁平的,看起来像蓝色的瘀伤,但后来慢慢变大。没有瘙痒、疼痛和其他不适的抱怨。体格检查:右膝一个3.2 cm × 2.1 cm的移动性violi肿瘤,由暗红色或蓝黑色的小泡组成,临床似淋巴管瘤边缘。皮肤镜检查显示中央暗红色、蓝色的腔隙、白色结构和周围棕色均匀区域,与海绵状血管瘤一致。患者行活检切除,经组织病理学检查确诊。
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引用次数: 0
Surgical pearl: A small handy apparatus for chemical cautery 外科用珍珠:一种用于化学烧灼的小而方便的器具
Pub Date : 2022-01-01 DOI: 10.4103/jdds.jdds_7_21
M. Mukhtar
{"title":"Surgical pearl: A small handy apparatus for chemical cautery","authors":"M. Mukhtar","doi":"10.4103/jdds.jdds_7_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_7_21","url":null,"abstract":"","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"201 2 1","pages":"43 - 44"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85614580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Journal of Dermatology and Dermatologic Surgery
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