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Efficacy and safety of 10,600 nm fractional carbon dioxide laser versus 88% phenol in treatment of idiopathic guttate hypomelanosis: A prospective study 10600 nm分数二氧化碳激光与88%苯酚治疗特发性低黑素症的疗效和安全性:一项前瞻性研究
Pub Date : 2022-01-01 DOI: 10.4103/jdds.jdds_24_22
K. Deepadarshan, M. Harish, B. Shashikumar, PriyankaR Chandran
Background: Idiopathic guttate hypomelanosis (IGH) is a common benign acquired leukodermic dermatosis characterized by multiple, discrete, hypopigmented-to-depigmented macules. Various treatment modalities were tried for this condition with varied results. Purpose: This study was conducted to compare the efficacy and safety of fractional carbon dioxide laser and 88% phenol in the treatment of IGH. Methods: A total of 40 patients with five IGH macules on each side were treated with one session of fractional carbon dioxide laser on the right side and a single application of 88% phenol on the left side and were assessed monthly for 3 months. The improvement in pigmentation was graded as ≤25% - poor, 26%–50% - minimal, 51%–75% - good, and >75% - excellent response. Results: A total of 32 patients completed the study. Out of the 160 macules treated with laser, 16 (10%) macules showed an excellent response and 40 (25%) showed a good response, and 40 (25%) and 48 (30%) macules in the phenol group showed excellent and good improvement, respectively. Side effects such as persistent scabbing and ulceration were seen only on the phenol side. Conclusion: Single application of 88% phenol was more efficacious than one session of fractional carbon dioxide laser in inducing pigmentation in IGH macules in this study. However, fractional carbon dioxide laser can be considered a safer alternative modality.
背景:特发性点滴型低黑色素病(IGH)是一种常见的良性获得性白皮病,其特征是多发、离散、低色素到脱色的斑点。针对这种情况尝试了各种治疗方法,结果各不相同。目的:比较分数二氧化碳激光与88%苯酚治疗IGH的疗效和安全性。方法:共40例患者,每侧5个IGH斑,右侧1次co2激光治疗,左侧1次88%苯酚治疗,每月评估3个月。色素沉着的改善分为≤25% -差,26%-50% -最小,51%-75% -好,>75% -极好。结果:共有32例患者完成了研究。在激光治疗的160个斑点中,16个(10%)斑点表现出优异的反应,40个(25%)斑点表现出良好的反应,苯酚组分别有40个(25%)和48个(30%)斑点表现出优异和良好的改善。副作用如持续结痂和溃疡只在酚侧可见。结论:单次应用88%苯酚诱导IGH斑色素沉着的效果优于单次co2激光。然而,分数二氧化碳激光可以被认为是一种更安全的替代方式。
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引用次数: 0
Atypical presentation of bullous herpes zoster and necrotizing fasciitis in immunocompromised patients 免疫功能低下患者的大疱性带状疱疹和坏死性筋膜炎的不典型表现
Pub Date : 2021-12-02 DOI: 10.38207/jmcrcs/2021/0216239
Fatimah Jawad Al Muqarrab, Mohammed Al Mozayen, Ayah Al Muqarrab, Mohammed J Almosbeh
Herpes zoster infection represents a localized reactivation state of latent varicella-zoster virus. Zoster presents as a grouped vesicular rash on an erythematous base distributed over sensory dermatomes. Disseminated zoster is defined as the presence of >20 vesicles outside the primary area or adjacent dermatomes. Atypical manifestations of zoster infection, especially in immunocompromised patients, may lead to delayed diagnosis, infection dissemination, and potentially life-threatening systemic complications. Bacterial superinfection of zoster lesions is a common complication; however, more serious deep soft-tissue infection is not. Here, we present two atypical cases of zoster infection, which needed a high index of suspicion to avoid misdiagnosis and inappropriate treatment. Our first patient is a 30-year-old Saudi male, with systemic lupus erythematosus on oral steroids who presented with a tense vesiculobullous eruption over two adjacent dermatomes. Biopsy revealed herpes infection. The second case is for a 58-year-old diabetic female who presented to the emergency department for evaluation of an extremely painful eruption in a dermatomal distribution 1 week after zoster resolution. Clinical and radiologic evaluation of the lesions identified necrotizing fasciitis. Although zoster commonly affects immunocompromised individuals, the atypical presentation of the initial lesions in our two patients was challenging. A high index of suspicion is required for early detection, with special consideration of the painful lesion in a cropped configuration.
带状疱疹感染代表潜伏水痘-带状疱疹病毒的局部再激活状态。带状疱疹表现为分布在感觉皮肤的红斑基础上的成组水疱疹。播散性带状疱疹定义为原发区或邻近皮节外存在bbbb20小泡。带状疱疹感染的非典型表现,特别是在免疫功能低下的患者中,可能导致诊断延误、感染传播和潜在的危及生命的全身并发症。带状疱疹的细菌重复感染是常见的并发症;然而,更严重的深层软组织感染是没有的。在这里,我们提出了两个不典型的带状疱疹感染病例,需要高度怀疑,以避免误诊和不适当的治疗。我们的第一位患者是一名30岁的沙特男性,患有口服类固醇的系统性红斑狼疮,表现为相邻两个皮节上紧张的囊泡性皮疹。活检显示疱疹感染。第二个病例是一名58岁的女性糖尿病患者,她在带状疱疹消退1周后因皮肤分布出现极度疼痛的皮疹而到急诊科就诊。临床及影像学检查发现坏死性筋膜炎。虽然带状疱疹通常影响免疫功能低下的个体,但我们两位患者的初始病变的非典型表现是具有挑战性的。早期发现需要高度的怀疑指数,特别考虑到裁剪配置中的疼痛病变。
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引用次数: 1
Quality of life and psychiatric comorbidity in vitiligo: A hospital-based cross-sectional study from a tertiary care center in South India 白癜风患者的生活质量和精神合并症:一项来自南印度三级保健中心的基于医院的横断面研究
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_113_20
P. Mathew, Deepthi Benny, Anoop Makkuni, Anoop Thyvalappil, R. Sridharan, AV Druhin
Background: Vitiligo is a common, acquired, idiopathic, depigmenting disorder with a profound effect on the patient's quality of life (QoL). Purpose: The objective of the study was to measure the QoL of patients with vitiligo using the dermatology life quality index (DLQI) and to assess psychiatric comorbidity in vitiligo patients using the General Health Questionnaire-28 (GHQ-28). Methods: Sixty patients above 16 years of age with vitiligo were enrolled. Age, sex, occupation, marital status, duration of disease, extent of involvement, visibility of lesions, details of treatment, duration of treatment, and response to treatment were collected. Independent t-test and ANOVA were used to test for significance of continuous variables and Chi-square test for categorical variables. Correlation between DLQI and GHQ-28 was assessed using Spearman's rho correlation coefficient. Results: Females scored higher than males on overall GHQ-28 scores and in individual domains of anxiety/insomnia, social dysfunction, and severe depression. Unmarried participants had higher scores compared to married subjects in all dimensions of DLQI and GHQ-28, indicating worse QoL and mental health. Conclusion: More than half of vitiligo patients had psychiatric comorbidity. There was a strong correlation between DLQI and GHQ-28 score, indicating strong association of QoL impairment with psychological problems. Proper counseling of patients of vitiligo along with specific treatment may be prudent.
背景:白癜风是一种常见的、获得性的、特发性的、脱色性疾病,对患者的生活质量(QoL)有深远的影响。目的:采用皮肤病生活质量指数(DLQI)评价白癜风患者的生活质量,采用普通健康问卷-28 (GHQ-28)评价白癜风患者的精神共病情况。方法:选取60例16岁以上白癜风患者。收集患者的年龄、性别、职业、婚姻状况、病程、累及程度、病变可见性、治疗细节、治疗持续时间和治疗反应。连续变量的显著性检验采用独立t检验和方差分析,分类变量的显著性检验采用卡方检验。采用Spearman’s rho相关系数评价DLQI与GHQ-28的相关性。结果:女性在GHQ-28总体得分和焦虑/失眠、社交功能障碍和严重抑郁的个别领域得分高于男性。与已婚受试者相比,未婚受试者在DLQI和GHQ-28的所有维度上得分更高,表明生活质量和心理健康状况更差。结论:超过半数的白癜风患者存在精神疾病。DLQI与GHQ-28评分有较强的相关性,表明生活质量损害与心理问题有较强的相关性。对白癜风患者进行适当的咨询以及特定的治疗可能是谨慎的。
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引用次数: 0
Red, necrotic papule and lymphadenopathy in an immunocompromised patient: Case report 免疫功能低下患者的红色坏死丘疹和淋巴结病:病例报告
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_66_20
E. Clarke, T. Willenbrink, B. Keeling
Immunocompromised patients, including those with acquired immunodeficiency syndrome (AIDS), are susceptible to a variety of opportunistic infections, cutaneous malignancies, and other skin lesions, which can present with nonspecific cutaneous findings. Herein, we present the case of a 28-year-old male with AIDS who presented with fatigue, left axillary lymphadenopathy, and a necrotic, red papule on the left upper arm. This case reviews the differential diagnosis of this presentation in an immunosuppressed patient including the key pathological findings.
免疫功能低下的患者,包括那些获得性免疫缺陷综合征(艾滋病)患者,容易受到各种机会性感染、皮肤恶性肿瘤和其他皮肤病变的影响,这些皮肤病变可能会出现非特异性的皮肤表现。在此,我们提出一个28岁的男性艾滋病患者的情况下,谁提出了疲劳,左腋窝淋巴结病,并在左上臂坏死,红色丘疹。本病例回顾了免疫抑制患者的鉴别诊断,包括关键的病理结果。
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引用次数: 0
Erratum: Effect of oral isotretinoin therapy on thyroid function in patients with moderate-to-severe acne vulgaris: A prospective study 口服异维甲酸治疗对中重度寻常痤疮患者甲状腺功能的影响:一项前瞻性研究
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_22_22
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引用次数: 0
Use of intramuscular triamcinolone acetonide in intermediate responders to janus kinase inhibition for alopecia areata: Case report 使用肌内曲安奈德对斑秃斑秃激酶抑制的中间反应者:病例报告
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_38_20
E. Araoye, C. Aguh
Janus kinase (JAK) inhibitors have been identified as an effective treatment option for severe alopecia areata (AA), but response is variable among patients. Intramuscular triamcinolone acetonide (IMTA), which has a greater bioavailability than other forms of steroids, has been used effectively to treat refractory AA with very few side effects. However, the use of IMTA in combination with JAK inhibitors is not well characterized. We present two patients with severe patch type AA and alopecia totalis who failed to achieve substantial regrowth after at least 6 months of oral tofacitinib and were treated with a single dose of IMTA 60 mg. Both patients had more than 50% increase in hair regrowth in areas of hair loss that had persisted on tofacitinib with no reported adverse effects.
Janus激酶(JAK)抑制剂已被确定为严重斑秃(AA)的有效治疗选择,但患者的反应各不相同。肌内注射曲安奈德(IMTA)比其他形式的类固醇具有更高的生物利用度,已被有效地用于治疗难治性AA,而且副作用很少。然而,IMTA联合JAK抑制剂的使用并没有很好地表征。我们报告了两例严重AA型贴片和全秃患者,他们在口服托法替尼至少6个月后未能实现实质性的再生,并接受了单剂量IMTA 60mg的治疗。两名患者在持续使用托法替尼的脱发区域的头发再生都增加了50%以上,没有报道有不良反应。
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引用次数: 0
Nail abnormalities associated with various dermatoses in a tertiary care center in North India: A cross-sectional study 指甲异常与各种皮肤病在北印度三级保健中心:横断面研究
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_22_21
A. David, E. Alexander, A. Bhatia
Background: Nail is an important structure both functionally and cosmetically. Nail examination is an integral part of a complete dermatological examination and can provide a clue in the diagnosis and severity of skin diseases. Purpose: The aim of the study is to study the pattern of nail changes in various dermatoses. Methods: The present study was a cross-sectional study conducted among 550 patients attending dermatology outpatient department in a tertiary care center in North India. A prestructured pro forma captured detailed demographic profile, clinical examination related to various dermatoses, and associated nail changes. KOH examination, fungal or bacterial culture, nail biopsy, and radiographic studies were done when indicated. The data analysis was done using the Statistical Package for Social Sciences (SPSS) version 21.0. Results: Majority of patients had onychomycosis (48%) followed by psoriasis (29%), paronychia (5%), vitiligo (4.7%), lichen planus (4%), and alopecia areata (2.3%). Twenty-nail dystrophy was noticed in three patients. The most common type of onychomycosis was distal lateral subungual onychomycosis (89%). Pits were seen in all psoriatic patients. Longitudinal ridges were the most frequent nail change in lichen planus (83%) and vitiligo (80%). Conclusion: Nails, in spite of being easily accessible for examination, are often overlooked. A variety of nail changes occur in various dermatological conditions and may be helpful in achieving a diagnosis.
背景:指甲是一个重要的功能和美容结构。指甲检查是完整皮肤病学检查的一个组成部分,可以为皮肤病的诊断和严重程度提供线索。目的:研究不同皮肤病患者指甲的变化规律。方法:本研究是一项横断面研究,在北印度三级保健中心皮肤科门诊就诊的550例患者中进行。预结构的形式捕获了详细的人口统计资料,与各种皮肤病相关的临床检查,以及相关的指甲变化。KOH检查,真菌或细菌培养,指甲活检和x线检查。数据分析使用社会科学统计软件包(SPSS) 21.0版完成。结果:以甲真菌病为主(48%),其次为银屑病(29%)、甲癣(5%)、白癜风(4.7%)、扁平苔藓(4%)、斑秃(2.3%)。3例患者出现二十指甲营养不良。最常见的甲真菌病类型是远侧甲下甲真菌病(89%)。所有银屑病患者均可见凹陷。纵脊是扁平苔藓(83%)和白癜风(80%)中最常见的指甲变化。结论:指甲虽易检查,但常被忽视。各种指甲变化发生在不同的皮肤病,可能有助于实现诊断。
{"title":"Nail abnormalities associated with various dermatoses in a tertiary care center in North India: A cross-sectional study","authors":"A. David, E. Alexander, A. Bhatia","doi":"10.4103/jdds.jdds_22_21","DOIUrl":"https://doi.org/10.4103/jdds.jdds_22_21","url":null,"abstract":"Background: Nail is an important structure both functionally and cosmetically. Nail examination is an integral part of a complete dermatological examination and can provide a clue in the diagnosis and severity of skin diseases. Purpose: The aim of the study is to study the pattern of nail changes in various dermatoses. Methods: The present study was a cross-sectional study conducted among 550 patients attending dermatology outpatient department in a tertiary care center in North India. A prestructured pro forma captured detailed demographic profile, clinical examination related to various dermatoses, and associated nail changes. KOH examination, fungal or bacterial culture, nail biopsy, and radiographic studies were done when indicated. The data analysis was done using the Statistical Package for Social Sciences (SPSS) version 21.0. Results: Majority of patients had onychomycosis (48%) followed by psoriasis (29%), paronychia (5%), vitiligo (4.7%), lichen planus (4%), and alopecia areata (2.3%). Twenty-nail dystrophy was noticed in three patients. The most common type of onychomycosis was distal lateral subungual onychomycosis (89%). Pits were seen in all psoriatic patients. Longitudinal ridges were the most frequent nail change in lichen planus (83%) and vitiligo (80%). Conclusion: Nails, in spite of being easily accessible for examination, are often overlooked. A variety of nail changes occur in various dermatological conditions and may be helpful in achieving a diagnosis.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"82 1","pages":"119 - 123"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83759254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between androgenic alopecia severity and the development of metabolic syndrome in Saudi Arabia: A case-control study 沙特阿拉伯雄激素性脱发严重程度与代谢综合征发展之间的关系:一项病例对照研究
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_139_20
A. Almudimeegh, K. Alekrish, Rakan A Bahammam, Ibrahim Alhedaithi, Khalid A Al Dakheel
Background: Androgenic alopecia (AGA) is a common type of chronic progressive hair loss that affects both males and females. AGA was shown to be associated with metabolic syndrome (MS) in many studies; the correlation between the AGA grade and MS, however, is still debatable. Purpose: The objective of the study was to assess the severity of AGA in a sample of patients suffering from this condition and its association with MS. Methods: This case–control study included 319 patients attending a dermatology clinic at a tertiary care hospital. Anthropometrics, blood pressure, lipid profile, and fasting blood sugar were collected from patients' records. Patients with AGA were allocated to the case group and were stratified based on severity using the Ludwig hair loss scale for females and the Norwood scale for males. The control group was composed of patients free of any hair condition. Data were analyzed using version 25 of SPSS. Results: MS was seen in 26.4% and 10.2% in cases and controls, respectively (P < 0.05). In terms of severity, MS was found in 21.6% of Grade I, 30.5% of Grade II, and 42.9% of Grade III patients. Although the findings showed no statistical significance (P > 0.05), the burden of MS was associated with the severity of AGA. Conclusion: Our findings suggest an association between MS and AGA and that burden of MS is associated with the severity of AGA, although the analysis showed no statistical significance. Based on our results, we think that early screening for MS might be beneficial to patients with AGA, as this will encourage early lifestyle modification to hopefully prevent future complications.
背景:雄激素性脱发(AGA)是一种常见的慢性进行性脱发,影响男性和女性。许多研究表明AGA与代谢综合征(MS)有关;然而,AGA分级与MS之间的相关性仍有争议。目的:本研究的目的是评估患有这种疾病的患者中AGA的严重程度及其与ms的关系。方法:本病例对照研究包括319名在三级保健医院皮肤科就诊的患者。从患者记录中收集人体测量、血压、血脂和空腹血糖。AGA患者被分配到病例组,并根据严重程度使用Ludwig脱发量表(女性)和Norwood脱发量表(男性)进行分层。对照组由无任何头发状况的患者组成。数据分析采用SPSS 25版。结果:病例组MS发生率为26.4%,对照组MS发生率为10.2% (P < 0.05)。就严重程度而言,MS在I级患者中占21.6%,在II级患者中占30.5%,在III级患者中占42.9%。虽然研究结果无统计学意义(P > 0.05),但MS负担与AGA严重程度相关。结论:我们的研究结果表明MS与AGA之间存在关联,MS的负担与AGA的严重程度相关,尽管分析结果没有统计学意义。基于我们的研究结果,我们认为MS的早期筛查可能对AGA患者有益,因为这将鼓励早期生活方式的改变,以防止未来的并发症。
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引用次数: 0
Dermatologic surgery training in dermatology residency programs in Saudi Arabia: A cross-sectional survey 沙特阿拉伯皮肤科住院医师项目中的皮肤外科培训:一项横断面调查
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_42_21
Norah Alsubait, Hadeel Mitwalli
Background: Dermatologic surgical procedures are expanding. Residents' training in procedural dermatology must evolve with the changes in the field. Purpose: We assessed the current status of surgical dermatology training in all Saudi Commission for Health Specialties (SCFHS)-accredited dermatology residency programs in Saudi Arabia. Methods: The survey was mailed to all 4th-year dermatology residents who completed the full 4 years of training at 5 SCFHS-accredited dermatology residency programs in December 2020. Statistical software SPSS (Version 22) was used to analyze responses. Results: A total of 26 4th-year residents participated, with a response rate of 89.6%. About 53.8% of the participants were equally assigned as the primary surgeons in laser for acne scar treatment and botulinum toxin for hyperhidrosis. Most of residents reported higher levels of nonexposure, especially for hair transplant procedures at 88.5%, fat transfer at 84.6%, fillers injection, and chemical peels at 65.4%. Regarding Mohs surgery, 73.1% of them are only knowledgeable through lectures and observations, without any hands-on training. The majority of residents (92.3%) were not satisfied with their dermatologic surgery training during residency. Conclusion: Residents express dissatisfaction with procedural and surgical dermatology training. Exposure in important areas of dermatologic surgery training could be better.
背景:皮肤外科手术正在扩大。住院医师在程序皮肤科的培训必须随着该领域的变化而发展。目的:我们评估了所有沙特卫生专业委员会(SCFHS)认可的沙特阿拉伯皮肤科住院医师项目的外科皮肤科培训现状。方法:该调查于2020年12月邮寄给所有在5个scfhs认可的皮肤科住院医师项目中完成了整整4年培训的四年级皮肤科住院医师。采用统计软件SPSS (Version 22)对调查结果进行分析。结果:共有26名四年级住院医师参与调查,回复率为89.6%。约53.8%的参与者被平均分配为激光治疗痤疮疤痕和肉毒杆菌毒素治疗多汗症的主要外科医生。大多数居民报告的非暴露水平较高,尤其是植发手术(88.5%)、脂肪移植(84.6%)、填充剂注射(65.4%)和化学换肤(65.4%)。关于莫氏手术,73.1%的人只通过讲座和观察了解,没有任何实际操作培训。绝大多数住院医师(92.3%)对住院期间的皮肤外科培训不满意。结论:住院医师对皮肤科的外科和程序培训表示不满。暴露在皮肤外科重要领域的培训可以更好。
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引用次数: 0
Microneedling with topical 5-fluorouracil in the localized stable vitiligo – Is this the way out? – Our experience: A hospital-based study 局部用5-氟尿嘧啶微针治疗稳定型白癜风-这是出路吗?-我们的经验:以医院为基础的研究
Pub Date : 2021-07-01 DOI: 10.4103/jdds.jdds_35_21
Ankit Singrodia, R. Mehta, Divyansha Sharma, P. Choudhary, B. Ghiya, Jyothi Bai S
Background: Vitiligo is a dermatological challenge with a major socio-psychological concern. Despite the availability of numerous medical and surgical treatment options, a single universally reliable therapeutic modality is yet to emerge due to the variability of response rate in different patients. Purpose: The objective of this study was to assess the safety and efficacy of microneedling along with topical 5-fluorouracil (5-FU) solution application in localized stable vitiligo. Methods: This open, nonrandomized, single-arm study was enrolled with 100 patients with localized stable vitiligo. Microneedling with topical 5-FU solution application was performed on 204 patches. The procedure was performed fortnightly for maximum 6 months. Results: At the end of 3 months, good to excellent (Grade IV) repigmentation was noted in 106 patches (51.96%) and Grade I to Grade II repigmentation was seen in 56 (27.45%) patches whereas at the end of follow-up, 128 (62.74%) patches showed good to excellent response. Conclusion: In conclusion, the results of this study showed that needling with 5-FU is a simple, cost-effective, and well-tolerated procedure which can be used as an alternative or additive modality in the treatment of localized stable vitiligo.
背景:白癜风是一种具有重大社会心理学关注的皮肤病挑战。尽管有许多医疗和手术治疗选择,但由于不同患者的反应率存在差异,尚未出现一种普遍可靠的治疗方式。目的:评价微针联合5-氟尿嘧啶(5-FU)溶液外用治疗局部稳定型白癜风的安全性和有效性。方法:这项开放、非随机、单臂研究纳入了100例局部稳定型白癜风患者。局部应用5-FU溶液微针治疗204个贴片。该手术每两周进行一次,最多持续6个月。结果:3个月结束时,良至优(IV级)重着色106个(51.96%),1至II级重着色56个(27.45%),随访结束时,良至优反应128个(62.74%)。结论:本研究结果表明,5-FU针刺是一种简单、经济、耐受性良好的治疗方法,可作为局部稳定型白癜风的替代或辅助治疗方式。
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引用次数: 0
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Journal of Dermatology and Dermatologic Surgery
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