首页 > 最新文献

Journal of Dental Sciences最新文献

英文 中文
Artificial intelligence applications in the diagnosis and management of cleft lip and palate: An updated review 人工智能在唇腭裂诊断和治疗中的应用综述
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.09.014
Tu Manh Nguyen , Uyen Ngoc Thao Huynh , Thi Thuy Tien Vo , Yang-Che Wu , Chien-Fu Tseng , I-Ta Lee
According to the U.S. National Institutes of Health, cleft lip and/or palate (CL/P) is one of the most common congenital anomalies, significantly affecting both function and aesthetics while placing a considerable burden on healthcare systems worldwide. With the rapid advancement of artificial intelligence (AI) in various medical fields, a thorough evaluation of its role in CL/P management has become essential. Therefore, this review was undertaken to summarize recent clinical applications of AI in the diagnosis, treatment, and care of CL/P. A comprehensive search of PubMed and IEEE Xplore was conducted from January 1, 2015, to May 31, 2025, using combined keywords related to AI and CL/P. Of the 134 records initially identified, 51 full-text articles met the eligibility criteria and were included in the final analysis. In conclusion, AI is driving innovation in CL/P management across multiple domains; however, further evidence from diverse populations and the establishment of clear ethical frameworks are required to ensure its long-term clinical applicability.
根据美国国立卫生研究院的数据,唇裂和/或腭裂(CL/P)是最常见的先天性畸形之一,严重影响功能和美观,同时给全球医疗保健系统带来了相当大的负担。随着人工智能(AI)在各个医疗领域的快速发展,对其在CL/P管理中的作用进行全面评估已成为必要。因此,本文综述了人工智能在CL/P诊断、治疗和护理方面的最新临床应用。综合检索2015年1月1日至2025年5月31日的PubMed和IEEE Xplore,结合AI和CL/P相关关键词进行检索。在最初确定的134条记录中,有51篇全文文章符合资格标准,并被纳入最终分析。总之,人工智能正在推动跨多个领域的CL/P管理创新;然而,需要来自不同人群的进一步证据和建立明确的伦理框架,以确保其长期临床适用性。
{"title":"Artificial intelligence applications in the diagnosis and management of cleft lip and palate: An updated review","authors":"Tu Manh Nguyen ,&nbsp;Uyen Ngoc Thao Huynh ,&nbsp;Thi Thuy Tien Vo ,&nbsp;Yang-Che Wu ,&nbsp;Chien-Fu Tseng ,&nbsp;I-Ta Lee","doi":"10.1016/j.jds.2025.09.014","DOIUrl":"10.1016/j.jds.2025.09.014","url":null,"abstract":"<div><div>According to the U.S. National Institutes of Health, cleft lip and/or palate (CL/P) is one of the most common congenital anomalies, significantly affecting both function and aesthetics while placing a considerable burden on healthcare systems worldwide. With the rapid advancement of artificial intelligence (AI) in various medical fields, a thorough evaluation of its role in CL/P management has become essential. Therefore, this review was undertaken to summarize recent clinical applications of AI in the diagnosis, treatment, and care of CL/P. A comprehensive search of PubMed and IEEE Xplore was conducted from January 1, 2015, to May 31, 2025, using combined keywords related to AI and CL/P. Of the 134 records initially identified, 51 full-text articles met the eligibility criteria and were included in the final analysis. In conclusion, AI is driving innovation in CL/P management across multiple domains; however, further evidence from diverse populations and the establishment of clear ethical frameworks are required to ensure its long-term clinical applicability.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 22-30"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of GPT-4o and Gemini Advanced on the Korean National Dental Licensing Examination: Accuracy, consistency, and question generation 韩国国家牙科执照考试gpt - 40和Gemini高级评估:准确性,一致性和问题生成
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.07.020
Eun Sun Song , Ga Hyeon Kim , Seung-Pyo Lee

Background/purpose

Large language models (LLMs), such as GPT-4o and Gemini Advanced, have performed strongly on global medical examinations. However, their capabilities in non-English, dentistry-specific licensing contexts remain unclear. Thus, this study aimed to compare the performance, consistency, and question-generation abilities of GPT-4o and Gemini Advanced in the Korean National Dental Licensing Examination (KNDLE).

Materials and methods

This study used 1,401 text-based KNDLE questions from 2019 to 2023 in Korean. Each model responded to the questions in three separate runs. Accuracy and consistency were compared with human answers. The models generated new questions in four subject areas and attempted to solve each other's generated items. Paired t-tests and chi-square tests were conducted.

Results

GPT-4o achieved significantly higher average accuracy than Gemini Advanced (81.1 % vs. 76.6 %, P = 0.013) and showed greater consistency across attempts. Both models performed better in basic sciences than in clinical subjects, such as prosthodontics. In cross-solving tasks, GPT-4o′s performance notably declined in Gemini-generated oral biology questions, indicating interpretation differences. However, the consistency difference between models was not significant (P = 0.578).

Conclusion

GPT-4o outperformed Gemini Advanced in accuracy, consistency, and alignment with its generated content. However, challenges remain in clinical domains and cross-model understanding, highlighting the potential of LLMs as supportive tools for non-English dental education and question generation while emphasizing the persistent need for expert oversight and domain-specific refinement.
大型语言模型(llm),如gpt - 40和Gemini Advanced,在全球医学检查中表现强劲。然而,他们在非英语、牙科特定许可环境中的能力仍不清楚。因此,本研究旨在比较gpt - 40和Gemini Advanced在韩国国家牙科执照考试(KNDLE)中的表现、一致性和问题生成能力。材料和方法本研究使用了2019年至2023年的1401个基于文本的韩国KNDLE问题。每个模型在三个单独的运行中回答问题。与人类答案的准确性和一致性进行了比较。这些模型在四个主题领域生成新问题,并试图解决彼此生成的问题。采用配对t检验和卡方检验。结果gpt - 40的平均准确率明显高于Gemini Advanced(81.1%对76.6%,P = 0.013),并且在不同的尝试中表现出更高的一致性。这两种模型在基础科学方面的表现都优于临床学科,如口腔修复学。在交叉解决任务中,gpt - 40在双子座生成的口头生物学问题中的表现明显下降,表明解释差异。但模型间一致性差异不显著(P = 0.578)。结论pt - 40在准确性、一致性和与其生成内容的一致性方面优于Gemini Advanced。然而,在临床领域和跨模型理解方面仍然存在挑战,强调llm作为非英语牙科教育和问题生成的支持工具的潜力,同时强调对专家监督和特定领域改进的持续需求。
{"title":"Evaluation of GPT-4o and Gemini Advanced on the Korean National Dental Licensing Examination: Accuracy, consistency, and question generation","authors":"Eun Sun Song ,&nbsp;Ga Hyeon Kim ,&nbsp;Seung-Pyo Lee","doi":"10.1016/j.jds.2025.07.020","DOIUrl":"10.1016/j.jds.2025.07.020","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Large language models (LLMs), such as GPT-4o and Gemini Advanced, have performed strongly on global medical examinations. However, their capabilities in non-English, dentistry-specific licensing contexts remain unclear. Thus, this study aimed to compare the performance, consistency, and question-generation abilities of GPT-4o and Gemini Advanced in the Korean National Dental Licensing Examination (KNDLE).</div></div><div><h3>Materials and methods</h3><div>This study used 1,401 text-based KNDLE questions from 2019 to 2023 in Korean. Each model responded to the questions in three separate runs. Accuracy and consistency were compared with human answers. The models generated new questions in four subject areas and attempted to solve each other's generated items. Paired t-tests and chi-square tests were conducted.</div></div><div><h3>Results</h3><div>GPT-4o achieved significantly higher average accuracy than Gemini Advanced (81.1 % vs. 76.6 %, <em>P</em> = 0.013) and showed greater consistency across attempts. Both models performed better in basic sciences than in clinical subjects, such as prosthodontics. In cross-solving tasks, GPT-4o′s performance notably declined in Gemini-generated oral biology questions, indicating interpretation differences. However, the consistency difference between models was not significant (<em>P</em> = 0.578).</div></div><div><h3>Conclusion</h3><div>GPT-4o outperformed Gemini Advanced in accuracy, consistency, and alignment with its generated content. However, challenges remain in clinical domains and cross-model understanding, highlighting the potential of LLMs as supportive tools for non-English dental education and question generation while emphasizing the persistent need for expert oversight and domain-specific refinement.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 96-102"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of the Vietnamese version of the patient's denture assessment questionnaire in complete denture wearers 越南版患者义齿评估问卷在全口义齿佩戴者中的验证
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.013
Trang Ngoc Huyen Bui , Yang-Che Wu , Chien-Fu Tseng , Thi Thuy Tien Vo , Van Thi Thao Nguyen , Yuriko Komagamine , Manabu Kanazawa , Chi-Fen Chang , I-Ta Lee , Pao-Chang Chiang

Background/purpose

The patient's denture assessment (PDA) is a standardized self-reported questionnaire developed in Japan to evaluate patient satisfaction with complete dentures. Although it has been validated in multiple languages, no validated version existed for the Vietnamese population. This study aimed to assess the psychometric properties of the Vietnamese version of the PDA (PDA-V) in a clinical sample of complete denture wearers.

Materials and methods

A cross-sectional validation study was conducted with 200 complete denture wearers in a public dental hospital in Vietnam. Internal consistency was assessed using Cronbach's α. Test-retest reliability was evaluated in a subsample of 120 participants after a 7–14 day interval using intraclass correlation coefficients (ICCs). Convergent validity was examined through correlation with a 100-mm visual analog scale (VAS) of global denture satisfaction. Discriminant validity was tested by comparing PDA-V scores between patients clinically judged as needing new dentures and those who did not.

Results

The PDA-V demonstrated excellent internal consistency across all six subscales (Cronbach's α = 0.82–0.87) and strong test-retest reliability (ICC = 0.86–0.92). A significant positive correlation was found between total PDA-V and VAS satisfaction scores (ρ = 0.78, P < 0.001), supporting convergent validity. Discriminant validity was confirmed by significantly lower PDA-V scores in patients assessed as needing new dentures (P < 0.01). No significant ceiling or floor effects were observed.

Conclusion

The PDA-V is a reliable and valid instrument for evaluating patient satisfaction with complete dentures. It is suitable for both clinical assessment and research purposes in the Vietnamese population.
背景/目的患者义齿评估(patient's denture assessment, PDA)是日本开发的一种标准化的自我报告问卷,用于评估患者对全口义齿的满意度。虽然它已在多种语言中得到验证,但没有针对越南人口的验证版本。本研究旨在评估越南版PDA (PDA- v)在全口义齿佩戴者临床样本中的心理测量特性。材料与方法对越南一家公立牙科医院的200名全口义齿佩戴者进行了横断面验证研究。采用Cronbach’s α评价内部一致性。使用类内相关系数(ICCs)在7-14天间隔后对120名参与者的子样本进行重测信度评估。通过与全口义齿满意度100毫米视觉模拟量表(VAS)的相关性来检验收敛效度。通过比较临床判定需要更换假牙的患者和不需要更换假牙的患者的PDA-V评分来检验判别效度。结果PDA-V量表具有良好的内部一致性(Cronbach′s α = 0.82 ~ 0.87)和较强的重测信度(ICC = 0.86 ~ 0.92)。总PDA-V与VAS满意度评分之间存在显著正相关(ρ = 0.78, P < 0.001),支持收敛效度。需要更换假牙的患者的PDA-V评分显著降低,证实了判别效度(P < 0.01)。没有观察到明显的上限或下限效应。结论PDA-V是一种可靠、有效的全口义齿满意度评价方法。它适用于越南人群的临床评估和研究目的。
{"title":"Validation of the Vietnamese version of the patient's denture assessment questionnaire in complete denture wearers","authors":"Trang Ngoc Huyen Bui ,&nbsp;Yang-Che Wu ,&nbsp;Chien-Fu Tseng ,&nbsp;Thi Thuy Tien Vo ,&nbsp;Van Thi Thao Nguyen ,&nbsp;Yuriko Komagamine ,&nbsp;Manabu Kanazawa ,&nbsp;Chi-Fen Chang ,&nbsp;I-Ta Lee ,&nbsp;Pao-Chang Chiang","doi":"10.1016/j.jds.2025.08.013","DOIUrl":"10.1016/j.jds.2025.08.013","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The patient's denture assessment (PDA) is a standardized self-reported questionnaire developed in Japan to evaluate patient satisfaction with complete dentures. Although it has been validated in multiple languages, no validated version existed for the Vietnamese population. This study aimed to assess the psychometric properties of the Vietnamese version of the PDA (PDA-V) in a clinical sample of complete denture wearers.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional validation study was conducted with 200 complete denture wearers in a public dental hospital in Vietnam. Internal consistency was assessed using Cronbach's α. Test-retest reliability was evaluated in a subsample of 120 participants after a 7–14 day interval using intraclass correlation coefficients (ICCs). Convergent validity was examined through correlation with a 100-mm visual analog scale (VAS) of global denture satisfaction. Discriminant validity was tested by comparing PDA-V scores between patients clinically judged as needing new dentures and those who did not.</div></div><div><h3>Results</h3><div>The PDA-V demonstrated excellent internal consistency across all six subscales (Cronbach's α = 0.82–0.87) and strong test-retest reliability (ICC = 0.86–0.92). A significant positive correlation was found between total PDA-V and VAS satisfaction scores (ρ = 0.78, <em>P</em> &lt; 0.001), supporting convergent validity. Discriminant validity was confirmed by significantly lower PDA-V scores in patients assessed as needing new dentures (<em>P</em> &lt; 0.01). No significant ceiling or floor effects were observed.</div></div><div><h3>Conclusion</h3><div>The PDA-V is a reliable and valid instrument for evaluating patient satisfaction with complete dentures. It is suitable for both clinical assessment and research purposes in the Vietnamese population.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 244-249"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Domiciliary dental care coverage in Taiwan: An assessment of provider participation and geographic distribution using the universal health coverage framework 台湾的居家牙科保健覆盖:利用全民健康覆盖框架评估提供者参与和地理分布
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.11.005
Chuan-Hang Yu

Background/purpose

Universal health coverage (UHC) ensures access to needed health services without financial hardship. While Taiwan has achieved near-universal coverage for most medical services, domiciliary dental care (DDC) for people with mobility limitations remains poorly integrated into the UHC framework. This study assessed DDC coverage in Taiwan using the World Health Organization UHC framework.

Materials and methods

Publicly available 2024 data were analyzed for dental institutions, practicing dentists, DDC providers, and long-term care populations across Taiwan's six National Health Insurance (NHI) regions and 22 administrative districts. Geographic distribution was examined using provider density metrics, Lorenz curves, and Gini coefficients.

Results

Among 7560 dental institutions, only 102 (1.3 %) provided DDC services, while 163 of 16,690 dentists (1.0 %) participated. Of 892,117 people who required long-term care, 23,379 (2.6 %) received DDC services. DDC represented 3.1 % of special needs dental services budget utilization. Geographic distribution demonstrated excellent equity with Gini coefficients of 0.064–0.082 and Lorenz curves above the equality line, indicating pro-rural distribution. However, service provision varied substantially: three districts had zero coverage, regional participation ranged from 0.5 % to 4.1 %, and provider density ranged from 0.7 to 3.9 per 10,000 people requiring care.

Conclusion

Despite comprehensive financial protection and equitable geographic distribution, critically low provider participation creates severe supply constraints that prevent most people requiring long-term care from accessing domiciliary oral health services. Taiwan has achieved equity in DDC distribution but not adequacy of supply, revealing substantial gaps in UHC achievement for vulnerable populations.
背景/目的全民健康覆盖(UHC)确保在没有经济困难的情况下获得所需的卫生服务。虽然台湾已经实现了大多数医疗服务的几乎全民覆盖,但针对行动不便人士的居家牙科保健(DDC)仍未纳入全民健康覆盖框架。本研究使用世界卫生组织全民健康覆盖框架评估台湾地区的DDC覆盖率。资料与方法分析台湾6个全民健保大区和22个行政区域的牙科机构、执业牙医、免赔金提供者和长期护理人口的公开数据。使用提供者密度指标、洛伦兹曲线和基尼系数检查地理分布。结果在7560家牙科机构中,仅有102家(1.3%)提供DDC服务,而在16690名牙医中,有163名(1.0%)参与了DDC服务。在需要长期护理的892,117人中,23,379人(2.6%)接受了DDC服务。DDC占特殊需要牙科服务预算利用率的3.1%。地理分布表现出良好的公平性,基尼系数在0.064 ~ 0.082之间,洛伦兹曲线位于平等线上,呈现亲农分布。然而,提供的服务差异很大:三个地区的覆盖率为零,区域参与率从0.5%到4.1%不等,提供者密度从每10,000名需要护理的人0.7到3.9不等。结论:尽管有全面的财政保护和公平的地域分配,但提供者参与程度极低造成了严重的供应限制,使大多数需要长期护理的人无法获得住家口腔保健服务。台湾在DDC分配上实现了公平,但在供应上不充足,这表明弱势群体的UHC成就存在很大差距。
{"title":"Domiciliary dental care coverage in Taiwan: An assessment of provider participation and geographic distribution using the universal health coverage framework","authors":"Chuan-Hang Yu","doi":"10.1016/j.jds.2025.11.005","DOIUrl":"10.1016/j.jds.2025.11.005","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Universal health coverage (UHC) ensures access to needed health services without financial hardship. While Taiwan has achieved near-universal coverage for most medical services, domiciliary dental care (DDC) for people with mobility limitations remains poorly integrated into the UHC framework. This study assessed DDC coverage in Taiwan using the World Health Organization UHC framework.</div></div><div><h3>Materials and methods</h3><div>Publicly available 2024 data were analyzed for dental institutions, practicing dentists, DDC providers, and long-term care populations across Taiwan's six National Health Insurance (NHI) regions and 22 administrative districts. Geographic distribution was examined using provider density metrics, Lorenz curves, and Gini coefficients.</div></div><div><h3>Results</h3><div>Among 7560 dental institutions, only 102 (1.3 %) provided DDC services, while 163 of 16,690 dentists (1.0 %) participated. Of 892,117 people who required long-term care, 23,379 (2.6 %) received DDC services. DDC represented 3.1 % of special needs dental services budget utilization. Geographic distribution demonstrated excellent equity with Gini coefficients of 0.064–0.082 and Lorenz curves above the equality line, indicating pro-rural distribution. However, service provision varied substantially: three districts had zero coverage, regional participation ranged from 0.5 % to 4.1 %, and provider density ranged from 0.7 to 3.9 per 10,000 people requiring care.</div></div><div><h3>Conclusion</h3><div>Despite comprehensive financial protection and equitable geographic distribution, critically low provider participation creates severe supply constraints that prevent most people requiring long-term care from accessing domiciliary oral health services. Taiwan has achieved equity in DDC distribution but not adequacy of supply, revealing substantial gaps in UHC achievement for vulnerable populations.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 551-561"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current challenges of safety management and supervision for the dental radiology diagnosis equipment in Taiwan 当前台湾牙科放射诊断设备安全管理与监管之挑战
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.09.005
Feng-Chou Cheng, Mu-Hsiung Chen, Sheau-Jing Yu, Chun-Pin Chiang
{"title":"Current challenges of safety management and supervision for the dental radiology diagnosis equipment in Taiwan","authors":"Feng-Chou Cheng,&nbsp;Mu-Hsiung Chen,&nbsp;Sheau-Jing Yu,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.09.005","DOIUrl":"10.1016/j.jds.2025.09.005","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 650-651"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathological premature loss of primary teeth and its influence on aberrant eruption of successors 乳牙病理性过早脱落及其对继发乳牙异常萌出的影响
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.038
Pakapol Wanitkitkurpol, Pornpoj Fuangtharnthip, Tsui-Hsein Huang, Chia-Tze Kao
{"title":"Pathological premature loss of primary teeth and its influence on aberrant eruption of successors","authors":"Pakapol Wanitkitkurpol,&nbsp;Pornpoj Fuangtharnthip,&nbsp;Tsui-Hsein Huang,&nbsp;Chia-Tze Kao","doi":"10.1016/j.jds.2025.08.038","DOIUrl":"10.1016/j.jds.2025.08.038","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 19-21"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tooth jewelry in rural Cambodia: An unexpected finding during dental volunteer service 柬埔寨农村的牙齿首饰:牙科志愿者服务期间的意外发现
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.012
Chuan-Hang Yu
{"title":"Tooth jewelry in rural Cambodia: An unexpected finding during dental volunteer service","authors":"Chuan-Hang Yu","doi":"10.1016/j.jds.2025.10.012","DOIUrl":"10.1016/j.jds.2025.10.012","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 677-678"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geographical distribution of hometowns of female dental graduates from Toyo girls dental college in Japan in 1932 1932年日本东洋女子牙科专科学校牙科女毕业生的家乡地理分布
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.015
Feng-Chou Cheng, Ling-Hsia Wang, Shiang-Yao Liu, Chun-Pin Chiang
{"title":"Geographical distribution of hometowns of female dental graduates from Toyo girls dental college in Japan in 1932","authors":"Feng-Chou Cheng,&nbsp;Ling-Hsia Wang,&nbsp;Shiang-Yao Liu,&nbsp;Chun-Pin Chiang","doi":"10.1016/j.jds.2025.10.015","DOIUrl":"10.1016/j.jds.2025.10.015","url":null,"abstract":"","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 662-664"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezo1-mediated mechanotransduction in cementocytes via protein kinase B and p38 mitogen-activated protein kinase signaling 通过蛋白激酶B和p38丝裂原激活的蛋白激酶信号传导,压电介导的骨水泥细胞机械转导
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.001
Kaixin Xiong , Yukihiko Sakisaka , Taichi Tenkumo , Eiji Nemoto , Kentaro Maruyama , Faisal Muhammad , Shigeki Suzuki , Hiroyuki Tada , Satoru Yamada

Background/purpose

Cementocytes, terminally differentiated cells embedded within cellular cementum, are morphologically similar to osteocytes; however, their mechanosensory function remains poorly understood. This study aimed to investigate whether Piezo1, a mechanosensitive ion channel, contributes to the regulation of osteo/cementogenic gene expression in murine cementocyte-like IDG-CM6 cells.

Materials and methods

IDG-CM6 cells were subjected to cyclic stretch or treated with Piezo1-specific agonist Yoda1 or antagonist GsMTx4. Expression levels of osteo/cementogenic genes (Wnt1, Sost, Opg) and protein levels were analyzed. The involvement of intracellular signaling pathways was assessed using pharmacological inhibitors targeting mitogen-activated protein kinase and protein kinase B (PKB/AKT) pathways.

Results

Cyclic stretch upregulated Wnt1 and Opg, and downregulated Sost expression, without altering Piezo1 expression, suggesting an enhanced osteo/cementogenic potential. These effects were abolished by GsMTx4 and closely mimicked by Yoda1 stimulation. The Yoda1-induced gene expression changes were transient and diminished after withdrawal. Inhibitor experiments confirmed that Piezo1-mediated gene expression is modulated primarily through the AKT and p38 signaling pathways. Phosphorylation of AKT and p38 was rapidly induced by cyclic stretch.

Conclusion

Our findings demonstrate that Piezo1 functions as a mechanosensor in cementocytes, modulating the expression of osteo/cementogenic genes via the AKT and p38 pathways. This study provides new insight into the molecular mechanisms of cementocyte mechanotransduction and may inform strategies for periodontal regeneration and orthodontic treatment.
背景/目的骨水泥细胞是嵌入在骨水泥内的终末分化细胞,在形态上与骨细胞相似;然而,它们的机械感觉功能仍然知之甚少。本研究旨在探讨Piezo1这种机械敏感离子通道是否有助于调节小鼠骨水泥细胞样IDG-CM6细胞中骨水泥基因的表达。材料和方法将sig - cm6细胞进行循环拉伸或使用piezo1特异性激动剂Yoda1或拮抗剂GsMTx4处理。分析成骨/骨质形成基因(Wnt1, Sost, Opg)的表达水平和蛋白水平。使用靶向丝裂原活化蛋白激酶和蛋白激酶B (PKB/AKT)通路的药物抑制剂评估细胞内信号通路的参与情况。结果cyclic拉伸上调Wnt1和Opg,下调Sost表达,但不改变Piezo1表达,表明其增强了成骨/骨质形成潜能。这些效应被GsMTx4消除,并被Yoda1刺激近似模拟。yoda1诱导的基因表达变化是短暂的,停药后减弱。抑制实验证实,piezo1介导的基因表达主要通过AKT和p38信号通路调节。循环拉伸快速诱导AKT和p38磷酸化。结论Piezo1在骨水泥细胞中发挥机械传感器的作用,通过AKT和p38通路调节骨水泥基因的表达。本研究为牙骨质细胞机械转导的分子机制提供了新的见解,并可能为牙周再生和正畸治疗提供策略。
{"title":"Piezo1-mediated mechanotransduction in cementocytes via protein kinase B and p38 mitogen-activated protein kinase signaling","authors":"Kaixin Xiong ,&nbsp;Yukihiko Sakisaka ,&nbsp;Taichi Tenkumo ,&nbsp;Eiji Nemoto ,&nbsp;Kentaro Maruyama ,&nbsp;Faisal Muhammad ,&nbsp;Shigeki Suzuki ,&nbsp;Hiroyuki Tada ,&nbsp;Satoru Yamada","doi":"10.1016/j.jds.2025.08.001","DOIUrl":"10.1016/j.jds.2025.08.001","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Cementocytes, terminally differentiated cells embedded within cellular cementum, are morphologically similar to osteocytes; however, their mechanosensory function remains poorly understood. This study aimed to investigate whether Piezo1, a mechanosensitive ion channel, contributes to the regulation of osteo/cementogenic gene expression in murine cementocyte-like IDG-CM6 cells.</div></div><div><h3>Materials and methods</h3><div>IDG-CM6 cells were subjected to cyclic stretch or treated with Piezo1-specific agonist Yoda1 or antagonist GsMTx4. Expression levels of osteo/cementogenic genes (<em>Wnt1</em>, <em>Sost</em>, <em>Opg</em>) and protein levels were analyzed. The involvement of intracellular signaling pathways was assessed using pharmacological inhibitors targeting mitogen-activated protein kinase and protein kinase B (PKB/AKT) pathways.</div></div><div><h3>Results</h3><div>Cyclic stretch upregulated <em>Wnt1</em> and <em>Opg</em>, and downregulated <em>Sost</em> expression, without altering <em>Piezo1</em> expression, suggesting an enhanced osteo/cementogenic potential. These effects were abolished by GsMTx4 and closely mimicked by Yoda1 stimulation. The Yoda1-induced gene expression changes were transient and diminished after withdrawal. Inhibitor experiments confirmed that Piezo1-mediated gene expression is modulated primarily through the AKT and p38 signaling pathways. Phosphorylation of AKT and p38 was rapidly induced by cyclic stretch.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that Piezo1 functions as a mechanosensor in cementocytes, modulating the expression of osteo/cementogenic genes via the AKT and p38 pathways. This study provides new insight into the molecular mechanisms of cementocyte mechanotransduction and may inform strategies for periodontal regeneration and orthodontic treatment.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 57-66"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigation-guided autotransplantation: A novel technique for precise and predictable tooth placement 导航引导自体移植:一种精确和可预测牙齿放置的新技术
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.027
Yang-Chih Chou , Wen-Hui Chen , Hui-Na Lee , Yu-Feng Chen
Autotransplantation (AT) is a promising alternative for restoring failed teeth. However, the success rate varies due to technique sensitivity and absence of standardized protocol. We present the first documented AT protocol utilizing a dynamic navigation system, including three core innovations: (1) navigation-guided socket preparation, (2) extra-alveolar retrograde filling, and (3) digital lingual stent fixation with flowable resin. A 55-year-old Taiwanese female with a vertical root fracture in tooth 36 underwent dynamic navigation-guided AT of tooth 38. The recipient area was prepared using a 2.5 mm wide round bur under the X-Guide® navigation. The X-Mark® probe was used to detect underprepared areas, and once preparation was deemed optimal, a three-dimensional (3D) replica was used for final confirmation. Tooth 38 was extracted and underwent retrograde filling, then transplanted into the socket of tooth 36 and fixed with a lingual stent. Postoperative image demonstrated ideal tooth positioning and favorable bone remodeling.
自体移植(AT)是一种很有前途的替代修复失败的牙齿。然而,由于技术敏感性和缺乏标准化的方案,成功率有所不同。我们提出了第一个使用动态导航系统的记录AT方案,包括三个核心创新:(1)导航引导的眼窝准备,(2)牙槽外逆行填充,(3)可流动树脂的数字舌支架固定。一位55岁台湾女性,第36颗牙牙根垂直骨折,接受第38颗牙的动态导航导引AT治疗。在X-Guide®导航下使用2.5 mm宽的圆垫准备受体区域。X-Mark®探针用于检测准备不足的区域,一旦准备被认为是最佳的,三维(3D)复制品用于最终确认。38号牙拔除后行逆行充填,移植至36号牙槽内,舌部支架固定。术后图像显示理想的牙齿定位和良好的骨重塑。
{"title":"Navigation-guided autotransplantation: A novel technique for precise and predictable tooth placement","authors":"Yang-Chih Chou ,&nbsp;Wen-Hui Chen ,&nbsp;Hui-Na Lee ,&nbsp;Yu-Feng Chen","doi":"10.1016/j.jds.2025.08.027","DOIUrl":"10.1016/j.jds.2025.08.027","url":null,"abstract":"<div><div>Autotransplantation (AT) is a promising alternative for restoring failed teeth. However, the success rate varies due to technique sensitivity and absence of standardized protocol. We present the first documented AT protocol utilizing a dynamic navigation system, including three core innovations: (1) navigation-guided socket preparation, (2) extra-alveolar retrograde filling, and (3) digital lingual stent fixation with flowable resin. A 55-year-old Taiwanese female with a vertical root fracture in tooth 36 underwent dynamic navigation-guided AT of tooth 38. The recipient area was prepared using a 2.5 mm wide round bur under the X-Guide® navigation. The X-Mark® probe was used to detect underprepared areas, and once preparation was deemed optimal, a three-dimensional (3D) replica was used for final confirmation. Tooth 38 was extracted and underwent retrograde filling, then transplanted into the socket of tooth 36 and fixed with a lingual stent. Postoperative image demonstrated ideal tooth positioning and favorable bone remodeling.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 599-603"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Dental Sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1