Journal of Dental Sciences最新文献

{"title":"Multi-institutional observational study on the relationship between oral infection focus and surgical site infection in artificial arthroplasty and the clinical significance of tooth extraction: An analysis using propensity score matching","authors":"Ryoji Kitamura ,&nbsp;Sakiko Soutome ,&nbsp;Naohisa Wada ,&nbsp;Daisuke Akita ,&nbsp;Takumi Hasegawa ,&nbsp;Narihiro Hirahara ,&nbsp;Yuichiro Imai ,&nbsp;Hideto Imura ,&nbsp;Yuki Hokita ,&nbsp;Shinichiro Kato ,&nbsp;Yuka Kojima ,&nbsp;Yuji Kusafuka ,&nbsp;Kousuke Matsumoto ,&nbsp;Yumiko Matsusue ,&nbsp;Hirokazu Nakahara ,&nbsp;Kanae Niimi ,&nbsp;Yu Ohashi ,&nbsp;Mitsunobu Otsuru ,&nbsp;Satoshi Rokutanda ,&nbsp;Hironori Sakai ,&nbsp;Nagato Natsume","doi":"10.1016/j.jds.2025.07.022","DOIUrl":"10.1016/j.jds.2025.07.022","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Surgical site infection (SSI) is a serious complication of artificial arthroplasty. Its relationship with dental infections and the necessity of preoperative dental screening remains debated. This study examined the relationship between oral condition and risk of SSI, along with preoperative tooth extraction effect, in patients undergoing artificial arthroplasty.</div></div><div><h3>Materials and methods</h3><div>Patients undergoing artificial hip or knee arthroplasty between April 2018 and September 2021 were retrospectively examined for age, sex, surgical site, surgical procedure, surgical time, preoperative hemoglobin level, white blood cell count, albumin level, creatinine level, remaining teeth, apical lesions ≥3 mm, periodontal pockets ≥4 mm, root fractures, residual roots, local infection symptoms in the oral cavity, preoperative or postoperative tooth extraction, and SSI occurrence. Tooth extraction effects on SSI incidence were analyzed using propensity score matching.</div></div><div><h3>Results</h3><div>The study included 3950 patients from 30 facilities. SSI occurred in 79 patients (2.0 %). Multivariate analysis identified surgery time and oral infection symptoms as significant risk factors. SSI occurred in 75 of 3793 patients without preoperative tooth extraction (2.0 %) and in 4 of 157 patients with tooth extraction (2.6 %), with no significant difference. However, in 292 propensity-matched patients, SSI incidences were 2.7 % and 6.2 % with and without preoperative extraction, respectively, indicating that preoperative infectious tooth removal may reduce SSI risk. Conversely, SSI occurred in three of seven patients (42.9 %) with tooth extraction within 60 days post-surgery, highlighting its risks.</div></div><div><h3>Conclusion</h3><div>Oral infections increase SSI risk after artificial arthroplasty. Preoperative tooth extraction is recommended to reduce this risk.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 88-95"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental caries prevalence and age-related patterns among populations remaining in war-affected regions of Ukraine","authors":"En-Tse Yen,&nbsp;Sung-Hsien Chiu,&nbsp;Wei-De Tsai,&nbsp;Gen-Min Lin,&nbsp;Kun-Zhe Tsai","doi":"10.1016/j.jds.2025.11.001","DOIUrl":"10.1016/j.jds.2025.11.001","url":null,"abstract":"<div><h3>Background/purpose</h3><div>The ongoing war in Ukraine has severely disrupted healthcare infrastructure, limiting access to preventive and restorative dental services. Most existing studies have focused on refugees abroad, while data from civilians who remained in conflict-affected regions are scarce. This study aimed to assess dental caries experience and age-related patterns among war-affected regions of Ukraine.</div></div><div><h3>Materials and methods</h3><div>A multinational medical team, in collaboration with local health institutions, delivered humanitarian medical and dental services in conflict-affected regions of Ukraine between September 17 and September 30, 2025. We retrospectively analyzed medical records from 230 civilians aged 12–85 years, assessing substance use, oral health behaviors, and dental caries experience, as quantified by the decayed, missing, and filled teeth (DMFT) index.</div></div><div><h3>Results</h3><div>The overall mean DMFT index was 9.93 ± 6.21, with 61.7 % of participants having at least one decayed tooth. A significant age gradient was observed, with DMFT increasing from 4.87 ± 3.33 in adolescents (12–19 years) to 15.39 ± 7.62 in elderly adults (≥65 years). In contrast, decayed teeth declined with age, from 2.13 ± 2.03 in adolescents to 0.70 ± 0.84 in elderly adults, while missing and filled teeth increased.</div></div><div><h3>Conclusion</h3><div>This study provides rare, clinically assessed evidence of a high burden of dental caries among Ukrainians remaining in war-affected areas. The observed age gradient and high prevalence of decayed teeth highlight the urgent need to restore access to dental care and to establish comprehensive oral health surveillance in postwar Ukraine.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 620-623"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial counts in saliva of patients with percutaneous endoscopic gastrostomy: Cross-sectional research","authors":"Madoka Funahara ,&nbsp;Akira Imakiire ,&nbsp;Ryuichiro Funahara ,&nbsp;Sakiko Soutome ,&nbsp;Yuki Sakamoto ,&nbsp;Masahiro Umeda","doi":"10.1016/j.jds.2025.06.027","DOIUrl":"10.1016/j.jds.2025.06.027","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Dysphagia in older adults requiring long-term care often necessitates nutritional management via percutaneous endoscopic gastrostomy (PEG). Although PEG effectively prevents food aspiration, it does not mitigate the risk of silent saliva aspiration, leaving patients vulnerable to aspiration pneumonia. The purpose of this study was to evaluate the bacterial count in the saliva of PEG users.</div></div><div><h3>Materials and methods</h3><div>This study included 13 PEG users and 13 oral feeders residing in a facility for individuals with disabilities. We investigated the participants’ age, sex, Eastern Cooperative Oncology Group performance status, oral wetness, Oral Hygiene Index Debris Index (OHI-DI), Winkel Tongue Coating Index (WTCI), number of teeth, and denture use. We also measured the number of bacteria in the saliva using the real-time polymerase chain reaction.</div></div><div><h3>Results</h3><div>The study population comprised 12 men and 14 women. The oral feeding group had an average age of 61.9 years, whereas the PEG group had a lower average age of 50.6 years. The PEG group exhibited lower OHI-DI scores compared to the oral feeding group. However, the salivary bacterial count in the PEG group was over 10 times higher than that in oral feeders. Multivariate analysis revealed a higher salivary bacterial load in PEG users than in oral feeders, independent of oral hygiene indicators such as OHI-DI, oral wetness, and WTCI.</div></div><div><h3>Conclusion</h3><div>PEG users demonstrated significantly higher salivary bacterial counts than oral feeders.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 109-114"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive insights and clinical pathways for managing congenitally missing mandibular incisors: A literature review","authors":"Daniel De-Shing Chen ,&nbsp;Johnson Hsin-Chung Cheng ,&nbsp;Gannaran Narangerel","doi":"10.1016/j.jds.2025.09.007","DOIUrl":"10.1016/j.jds.2025.09.007","url":null,"abstract":"<div><div>Congenitally missing mandibular incisors present a unique clinical challenge in orthodontics due to their relative rarity and association with craniofacial variations. This literature review synthesized existing case reports and studies to outline diagnostic considerations, craniofacial characteristics, etiology, and treatment strategies. Genetic factors, developmental anomalies of the mandibular symphysis, and evolutionary theories have been implicated in the etiology of incisor agenesis, with higher prevalence observed in East Asian populations. Affected individuals often exhibit skeletal Class III tendencies and distinctive mandibular symphysis morphology. Treatment modalities include extraction strategies, space closure, and prosthetic space creation, with planning guided by Bolton analysis, digital model setup, and facial esthetics. A treatment decision flowchart was developed based on decades of clinical evidence to support individualized, interdisciplinary care. Advances in 3D imaging and digital simulation offer enhanced precision in evaluating treatment feasibility and outcomes. This review emphasizes the importance of integrating skeletal analysis, occlusal balance, and patient-specific factors to achieve optimal functional and esthetic results in cases of congenitally missing mandibular incisors.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 367-373"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of second mesiobuccal canal in maxillary first and second molar detected using cone-beam computed tomography in the Han population: A systemic review and meta-analysis","authors":"Jaan-Yih Wu ,&nbsp;Ho-Sheng Chiang ,&nbsp;Yi-Jie Chen ,&nbsp;Zi-Jun Dai ,&nbsp;Yen-Ching Chao ,&nbsp;Hsu-Hua Chu ,&nbsp;Yi-Shing Shieh ,&nbsp;Yu-Chiao Wu","doi":"10.1016/j.jds.2025.09.008","DOIUrl":"10.1016/j.jds.2025.09.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>A thorough understanding of root canal morphology, particularly the second mesiobuccal (MB2) canal, is crucial for successful endodontic treatment of maxillary molars. The prevalence of MB2 shows ethnic variability, and this systematic review and meta-analysis aimed to synthesize existing CBCT-based studies to determine the prevalence of the second mesiobuccal canal (MB2) in the Han population.</div></div><div><h3>Materials and methods</h3><div>A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases including PubMed, MEDLINE, Scopus, and ClinicalKey were searched through 17th August 2025. Studies reporting MB2 prevalence in permanent maxillary first and/or second molars within Han populations using CBCT were included. Data were pooled using a random-effects model.</div></div><div><h3>Results</h3><div>Fourteen eligible studies involving 15,639 participants and 35,929 teeth were analyzed. The pooled MB2 prevalence was 63.7 % for permanent maxillary first molars (PMFMs) and 23.3 % for permanent maxillary second molars (PMSMs). Males had significantly higher odds of having MB2 canals in both molar types (Odds Ratio = 1.532 and 1.790, respectively). No significant difference was found between left and right sides. Heterogeneity was high (<em>I</em>^<em>2</em> &gt; 95 %), but most studies were of high methodological quality.</div></div><div><h3>Conclusion</h3><div>MB2 canals are common in the Han population, particularly in PMFMs. Clinicians may consider advanced imaging like CBCT to improve detection and treatment outcomes. Sex-related differences further underscore the need for individualized diagnostic approaches.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 333-340"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of bio-compatible isosorbide-based polyurethanes exhibiting eucalyptol solubility for advanced root canal filling applications","authors":"Yuen-Shan Tsai ,&nbsp;Sheng-Wun Huang ,&nbsp;Yin-Lin Wang ,&nbsp;Shu-Fang Chang ,&nbsp;Chun-Pin Lin","doi":"10.1016/j.jds.2025.10.002","DOIUrl":"10.1016/j.jds.2025.10.002","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Gutta-percha (GP) has long been the standard root canal filling material, but its poor removability, limited mechanical properties, and potential cytotoxicity restrict clinical performance. To address these shortcomings, this study aimed to develop bio-based D-isosorbide thermoplastic polyurethanes (IPUs) with improved removability in eucalyptol oil, superior mechanical performance, and enhanced cytocompatibility, providing a potential alternative to GP.</div></div><div><h3>Materials and methods</h3><div>D-isosorbide-based IPUs were synthesized from polycarbonate polyol and D-isosorbide via catalyst-free, two-step polymerization. Four formulations with different hard segment contents (HS10–HS40) were prepared and evaluated for thermal stability (thermogravimetric analysis and differential scanning calorimetry), mechanical properties (tensile testing), solubility in eucalyptol oil, and cytocompatibility (CCK-8 and LDH assays), compared with GP.</div></div><div><h3>Results</h3><div>All IPUs showed high thermal stability (T₅d &gt; 270 °C) and melting transitions between 44 and 48 °C, similar to GP. Among the formulations, IPU-30 demonstrated optimal performance, achieving a tensile strength of 11.8 ± 1.0 MPa and elongation at break of 721 ± 144 %, markedly surpassing GP. Solubility in eucalyptol increased with D-isosorbide content, with IPU-40 exhibiting up to 13 % mass loss. In cytocompatibility assays, IPU-30 displayed lower early-phase cytotoxicity and maintained higher cell viability than GP over 6 days.</div></div><div><h3>Conclusion</h3><div>D-isosorbide-based IPUs combine favorable thermal and mechanical properties with partial solubility in eucalyptol, enabling easier and safer retreatment. Their excellent cytocompatibility further supports their potential as sustainable and clinically viable alternatives to GP in root canal obturation.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 410-418"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hydrogen peroxide concentration on plasma arc-activated tooth bleaching: An in vitro study","authors":"Pei-Ling Lai ,&nbsp;Ping-Hui Liao ,&nbsp;Po-Sung Fu ,&nbsp;Chih-Te Liu ,&nbsp;Wen-Cheng Chen ,&nbsp;Chun-Cheng Hung","doi":"10.1016/j.jds.2025.10.008","DOIUrl":"10.1016/j.jds.2025.10.008","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Tooth bleaching was a conservative treatment compared with veneer and crown restorations that causes damage of teeth structure. This study evaluated the effectiveness of different concentrations of hydrogen peroxide combined with plasma arc activation for tooth whitening, focusing on tooth shade, microhardness, and surface roughness.</div></div><div><h3>Materials and methods</h3><div>The extracted teeth were standardized to ensure consistent surface conditions. They were bleached using various concentrations of 20 %–35 % hydrogen peroxide, with or without plasma arc activation. After the bleaching process, the shade, microhardness, and surface roughness of the teeth were measured before, during, and after the first and fourth bleaching cycles.</div></div><div><h3>Results</h3><div>The concentration of hydrogen peroxide significantly affected tooth color changes following a single plasma arc bleaching cycle. After the fourth cycle, all concentrations except for the 23 % hydrogen peroxide showed effects on tooth color and microhardness due to plasma arc activation, with roughness being the most notably impacted indicator. Therefore, while plasma arc treatment enhanced the efficacy of tooth whitening, it also significantly reduced microhardness, especially within the hydrogen peroxide concentration range of 26 %–35 %.</div></div><div><h3>Conclusion</h3><div>We suggest using a 26 % peroxide solution instead of high-concentration hydrogen peroxide, activated by a plasma arc, to achieve the same teeth whitening results while minimizing damage to the tooth surface.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 419-428"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts","authors":"Ya-Lun Li ,&nbsp;Yang-Che Wu ,&nbsp;Chien-Fu Tseng ,&nbsp;Yung-Li Wang ,&nbsp;Sin-Yu Li ,&nbsp;Thi Thuy Tien Vo ,&nbsp;Yuh-Lien Chen ,&nbsp;Yin-Tzer Shih ,&nbsp;I-Ta Lee","doi":"10.1016/j.jds.2025.10.022","DOIUrl":"10.1016/j.jds.2025.10.022","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Particulate matter (PM) exposure is associated with inflammation and extracellular matrix degradation in periodontal tissues. Cyclooxygenase-2 (COX-2), prostaglandin E₂ (PGE₂), and matrix metalloproteinase-1 (MMP-1) are key mediators in these processes. Nattokinase, a fibrinolytic enzyme derived from <em>Bacillus subtilis</em> fermentation, has recently gained attention for its potent anti-inflammatory and antioxidant effects.</div></div><div><h3>Materials and methods</h3><div>Human gingival fibroblasts (HGF-1 cells) were exposed to PM, and the protective effects of nattokinase pretreatment were systematically evaluated. COX-2, PGE₂, and MMP-1 expression and release were analyzed using immunoblotting and enzyme-linked immunosorbent assay. The roles of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS), phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and mitogen-activated protein kinase (MAPK) pathways were examined using pharmacological inhibitors. The nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) axis was validated by inhibitors and antioxidant response element (ARE)-luciferase assays.</div></div><div><h3>Results</h3><div>PM stimulation induced COX-2 expression, PGE₂ release, and MMP-1 upregulation in HGF-1 cells through NADPH oxidase-mediated ROS generation, PI3K/Akt activation, and phosphorylation of p42/p44 MAPK and p38 MAPK. ROS and PI3K/Akt exhibited bidirectional regulation reinforcing COX-2 and MMP-1 induction. Nattokinase pretreatment markedly suppressed these pro-inflammatory and matrix-degrading responses. Mechanistically, nattokinase enhanced Nrf2 activation and HO-1 expression, thereby attenuating PM-induced signaling cascades and mediator release. Inhibition of Nrf2 or HO-1 abolished nattokinase's protective effects.</div></div><div><h3>Conclusion</h3><div>Nattokinase protects HGF-1 cells from PM-induced inflammation and matrix degradation by activating the Nrf2/HO-1 axis and suppressing NADPH oxidase-derived ROS, effectively interrupting the reciprocal regulation between ROS, PI3K/Akt, and MAPK pathways.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 457-467"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful prevention of medication-related osteonecrosis of the jaw after dental extractions by socket preservation with alloplast plus tetracycline in patients taking antiresorptive drugs","authors":"Liang-Ho Lin ,&nbsp;Chun-Hsiang Wang ,&nbsp;Shin-Yu Lu","doi":"10.1016/j.jds.2025.10.020","DOIUrl":"10.1016/j.jds.2025.10.020","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of antiresorptive, antiangiogenic or targeted agents, and usually occurs after dental extraction. The etiopathogenesis of MRONJ is multifactorial and not fully understood. MRONJ remains difficult to treat. Precluding MRONJ occurrence is therefore essential. We offer our experiences and treatment strategies regarding the successful prevention of MRONJ after tooth extractions in patients taking antiresorptive drugs (ARDs).</div></div><div><h3>Materials and methods</h3><div>Under ARDs cessation of at least 3 months before and after oral surgery, 106 consecutive patients who underwent 249 dental extractions on 137 occasions were examined according to complete follow-up data. Among them, 42 patients (39.7 %) were classified as higher risk by the Scottish Dental Clinical Effectiveness Program (SDCEP) guidance. All extractions were performed under perioperative antibiotic prophylaxis. Each extraction involved socket preservation with alloplastic bone graft plus tetracycline and then covering it with a flatted Gelfoam and suturing. Post-operative antimicrobial mouthwash was advised.</div></div><div><h3>Results</h3><div>In 105 patients (99.1 %) with 248 dental extractions (99.6 %), MRONJ was successfully prevented despite most extraction sockets without primary closure. Only one tooth extraction (0.4 %) in a lower-risk patient developed MRONJ due to resuming denosumab one-month post-extraction before completing healing of socket. No one suffered skeletal-related events during the withdrawal of ARDs.</div></div><div><h3>Conclusion</h3><div>The study demonstrates a high prevention effect of socket preservation with alloplast plus tetracycline on reducing MRONJ occurrence after tooth extraction. Enough drug holiday and antimicrobial mouthwash plus systemic antibiotics before and after surgery are recommended. Primary closure is likely unnecessary.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 468-474"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a checklist for evaluating root canal treatment performance in Taiwan","authors":"Tien-Hao Chang ,&nbsp;Yong-Chen Huang ,&nbsp;Shu-Hui Chang ,&nbsp;Stanley Shih-Li Tsai ,&nbsp;Yi-Ling Tsai","doi":"10.1016/j.jds.2025.10.035","DOIUrl":"10.1016/j.jds.2025.10.035","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Over the past decade, numerous efforts have been made to develop guidelines for endodontic education; however, there has been no corresponding reform of the assessment scale. This study aimed to adopt an integrative approach to develop a checklist that summarizes the guidelines into key points for evaluating root canal treatment performance.</div></div><div><h3>Materials and methods</h3><div>We followed the modified Delphi method and employed a five-step process to develop the checklist. Eight experts were recruited to develop the checklist, each with at least 7 years of clinical dentistry experiences, including a minimum 5 years in endodontics, as well as at least 3 years of teaching experience. Inter-rater reliability was assessed by three experts who applied the final item-weighted checklist to evaluate 66 extracted natural teeth operated by students who were about to enter pre-clinical training. Both experts and students were asked to provide feedback regarding the content validity of the checklist.</div></div><div><h3>Results</h3><div>The careful development process with expert opinions supported the content validity. The final checklist includes 15 key items designed to measure comprehensive root canal treatment skills. The inter-rater reliability ranged from 0.437 to 0.865, indicating acceptable agreement among raters. Both teachers and students confirmed that the items were clear, comprehensible, and relevant, thereby supporting the face validity of the checklist.</div></div><div><h3>Conclusion</h3><div>This study developed the first qualitative checklist in Taiwan for assessing root canal treatment techniques using a structured approach and the modified Delphi method. The checklist offers teachers a standardized assessment tool and enhances learning efficiency for students.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 501-508"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}