Journal of Dental Sciences最新文献

英文中文

Zoledronate enhances lipopolysaccharide-induced inflammation via toll-like receptor 4 upregulation 唑来膦酸钠通过toll样受体4上调来增强脂多糖诱导的炎症

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.06.004

Kanan Bando , Yasuo Endo

Background/Purpose

Bisphosphonates (BPs) are commonly used to treat osteoporosis and bone metastases, but their use is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ), a condition characterized by chronic inflammation and impaired healing. Since bacterial infection is a major risk factor for BRONJ, this study investigated whether zoledronate (Zol), a nitrogen-containing BP, modulates Toll-like receptor 4 (TLR4) expression and enhances lipopolysaccharide (LPS)-induced inflammation.

Materials and methods

Zol or other BPs were injected into the ear pinnae of mice. Five days later, tissues were harvested and analyzed by flow cytometry and ELISA to assess TLR4 expression and cytokine production. TLR4 expression in immune cells and keratinocytes was evaluated, and inflammatory cytokine production (IL-1β, TNF-α) was measured after LPS stimulation.

Results

TLR4 expression was significantly increased in keratinocytes and neutrophils after Zol administration, whereas it was decreased in macrophages due to an increased proportion of inflammatory macrophage subsets with intrinsically low TLR4 expression. Zol-treated neutrophils exhibited elevated IL-1β and TNF-α production following LPS stimulation. Co-administration of Zol and LPS markedly enhanced local inflammation compared to either agent alone.

Conclusion

Zoledronate upregulates TLR4 expression in neutrophils and keratinocytes and augments LPS-induced inflammation, suggesting a mechanism by which BPs exacerbate oral inflammatory responses. These findings provide new insight into the pathogenesis of BRONJ and suggest that targeting TLR4 signaling may be a potential strategy to mitigate BP-associated oral complications.

背景/目的双膦酸盐（bp）通常用于治疗骨质疏松症和骨转移，但它们的使用与双膦酸盐相关的颌骨骨坏死（BRONJ）有关，这是一种以慢性炎症和愈合受损为特征的疾病。由于细菌感染是BRONJ的主要危险因素，本研究探讨了含氮BP唑来膦酸盐（Zol）是否调节toll样受体4 （TLR4）表达并增强脂多糖（LPS）诱导的炎症。材料与方法将ol或其他bp注入小鼠耳廓。5天后，采集组织，用流式细胞术和ELISA检测TLR4的表达和细胞因子的产生。检测免疫细胞和角质形成细胞中TLR4的表达，检测LPS刺激后炎症因子（IL-1β、TNF-α）的产生。结果Zol给药后，stlr4在角质形成细胞和中性粒细胞中的表达显著增加，而在巨噬细胞中，由于TLR4低表达的炎性巨噬细胞亚群比例增加，其表达降低。zol处理的中性粒细胞在LPS刺激后IL-1β和TNF-α的产生升高。与单独使用任何一种药物相比，Zol和LPS联合使用明显增强了局部炎症。结论唑来膦酸盐上调中性粒细胞和角质形成细胞中TLR4的表达，增强lps诱导的炎症反应，提示bp加剧口腔炎症反应的机制。这些发现为BRONJ的发病机制提供了新的见解，并表明靶向TLR4信号通路可能是减轻bp相关口腔并发症的潜在策略。

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引用次数: 0

Analysis of multimodal large language models on visually-based questions in the Japanese National Examination for Dental Hygienists: A preliminary comparative study 日本全国口腔保健师考试中基于视觉的问题的多模态大语言模型分析：初步比较研究

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.06.005

Yoshino Kaneyasu , Yuichi Mine , Yoshie Niitani , Tsuyoshi Taji , Saori Takeda , Ryohei Tokinaga , Hideo Shigeishi , Toshinobu Takemoto , Naoya Kakimoto , Takeshi Murayama , Kouji Ohta

Background/purpose

The importance of oral health is globally recognized, which has increased the demand for qualified dental hygienists. This study assessed the performance of multimodal large language models (LLMs), on the Japanese National Examination for Dental Hygienists, focusing on their ability to answer visually-based questions and evaluating image-recognition capabilities.

Materials and methods

The 34th Japanese National Examination for Dental Hygienists (March 2025) supplied 213 multiple-choice questions (74 text-only, 139 visually-based). Five multimodal LLMs were tested: OpenAI o3-mini-high (o3-mh), ChatGPT-4.5 Preview (GPT-4.5), Gemini 2.0 Flash Thinking Experimental (Gemini 2.0), Gemini 2.5 Pro Experimental (Gemini 2.5), and Claude 3.7 Sonnet (Claude 3.7). Performance was evaluated by comparing LLM answers to official correct answers. Cochran's Q test and McNemar's tests with Bonferroni correction were used for statistical analysis.

Results

Gemini 2.5 achieved the highest overall correct response rate (85.0 %), followed by Claude 3.7 (77.5 %), o3-mh (77.0 %), GPT-4.5 (76.1 %), and Gemini 2.0 (75.1 %). For text-only questions, Claude 3.7 (91.9 %) performed best. On visually-based questions, Gemini 2.5 was superior (82.0 %), while other models scored around 70–73 %. Gemini 2.5 significantly outperformed, GPT-4.5 and Gemini 2.0 overall, and GPT-4.5 and Claude 3.7 on visually-based questions.

Conclusion

Multimodal LLMs, particularly Gemini 2.5, demonstrate significant proficiency on the Japanese National Examination for Dental Hygienists, including questions with visual elements. These findings suggest a growing potential for LLMs as educational tools in dental hygiene. However, current limitations in accuracy and reliability necessitate further refinement and cautious integration into educational and clinical settings.

背景/目的全球都认识到口腔健康的重要性，这增加了对合格牙科保健师的需求。本研究评估了多模态大语言模型（llm）在日本国家牙科保健师考试中的表现，重点关注他们回答基于视觉的问题和评估图像识别能力的能力。材料和方法第34届日本国家牙科保健师考试（2025年3月）提供213个选择题（74个纯文本，139个基于视觉）。测试了五个多模式llm: OpenAI o3-mini-high （o3-mh）、ChatGPT-4.5 Preview （GPT-4.5）、Gemini 2.0 Flash Thinking Experimental （Gemini 2.0）、Gemini 2.5 Pro Experimental （Gemini 2.5）和Claude 3.7 Sonnet （Claude 3.7）。通过比较LLM答案与官方正确答案来评估绩效。采用Cochran’s Q检验和McNemar’s检验进行统计分析，并进行Bonferroni校正。结果Gemini 2.5整体正确率最高（85.0%），Claude 3.7（77.5%）、03 -mh（77.0%）、GPT-4.5（76.1%）、Gemini 2.0（75.1%）次之。对于纯文本问题，Claude 3.7（91.9%）表现最好。在基于视觉的问题上，Gemini 2.5的得分更高（82.0%），而其他型号的得分在70 - 73%左右。在基于视觉的问题上，Gemini 2.5的总体表现明显优于GPT-4.5和Gemini 2.0，以及GPT-4.5和Claude 3.7。结论：多模式法学硕士，特别是Gemini 2.5，在日本国家牙科保健师考试中表现出显著的熟练程度，包括视觉元素的问题。这些发现表明，法学硕士作为口腔卫生教育工具的潜力越来越大。然而，目前在准确性和可靠性方面的限制需要进一步完善和谨慎地整合到教育和临床环境中。

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引用次数: 0

The roles of CD24-Sec14 like lipid binding 2 (SEC14L2) axis in the neoplastic progression of oral squamous cell carcinomas CD24-Sec14样脂质结合2 （SEC14L2）轴在口腔鳞状细胞癌肿瘤进展中的作用

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.014

Shi-Rou Chang , Chung-Hsien Chou , Chung-Ji Liu , Kuo-Wei Chang , Jian-Hua Pan , Sheng-Lin Yen , Shu-Chun Lin

Background/purpose

Immune stimulation or escape are critical factors determining the survival of malignancies, including oral squamous cell carcinoma (OSCC) and head and neck SCC (HNSCC). CD24 (CD24A in mice) is a glycoprotein anchored to cell membranes, modulating macrophages' immune responses, cell interaction, tumorigenesis, and stemness. However, its roles in the OSCC pathogenesis are still controversial. The modulation of CD24 on the oncogenicity and immunity of OSCC were investigated in this study.

Materials and methods

Knockdown approaches and the establishment of stable tet-off CD24 expression cell subclones were used in cell and mouse models for phenotypic and transcriptomic analysis. Bioinformatic assessments were performed to specify the clinicopathological implications.

Results

CD24 expression modulated the increase of migration and invasion and the upregulation of phosphatidylcholine/phosphatidylinositol transfer protein Sec14 like lipid binding 2 (SEC14L2) expression. The syngeneic grafts of CD24 tet-off expressing murine OSCC cell subclones exhibited modest changes of immune cell infiltration within tumors and were devoid of immune profile disruption in the recipient's neck lymph node and spleen. The shutdown of CD24 with doxycycline treatment drastically suppressed the growth of CD24 tet-off tumors. A correlation between CD24 expression and myeloid dendritic cell population was noted in murine and human OSCC tissue. Concordances in CD24 and SEC14L2 expression and oncogenic induction were noted in murine tumors. SEC14L2 was upregulated in HNSCC/OSCC tumors, and it was an unfavorable survival predictor.

Conclusion

This study's elucidation of the oncogenic potential of the CD24-SEC14L2 axis may signify the therapeutic efficacy of CD24 targeting for HNSCC/OSCC.

背景/目的免疫刺激或逃逸是决定恶性肿瘤生存的关键因素，包括口腔鳞状细胞癌（OSCC）和头颈部鳞状细胞癌（HNSCC）。CD24（小鼠中的CD24A）是一种固定在细胞膜上的糖蛋白，调节巨噬细胞的免疫反应、细胞相互作用、肿瘤发生和干性。然而，其在OSCC发病机制中的作用仍存在争议。本研究探讨了CD24对OSCC致癌性和免疫的调节作用。材料和方法在细胞和小鼠模型中采用敲低方法和建立稳定的CD24表达细胞亚克隆进行表型和转录组学分析。进行生物信息学评估以明确临床病理意义。结果scd24的表达调节了磷脂酰胆碱/磷脂酰肌醇转移蛋白Sec14样脂质结合2 （SEC14L2）表达的上调和迁移侵袭的增加。表达CD24的小鼠OSCC细胞亚克隆的同基因移植物在肿瘤内表现出适度的免疫细胞浸润变化，并且在受体的颈部淋巴结和脾脏中没有免疫谱破坏。多西环素治疗关闭CD24可显著抑制CD24释放肿瘤的生长。在小鼠和人OSCC组织中，CD24的表达与骨髓树突状细胞群之间存在相关性。在小鼠肿瘤中发现了CD24和SEC14L2表达和致癌诱导的一致性。SEC14L2在HNSCC/OSCC肿瘤中上调，是一个不利的生存预测因子。结论本研究阐明了CD24- sec14l2轴的致瘤潜能，可能预示着CD24靶向治疗HNSCC/OSCC的疗效。

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引用次数: 0

Measurement of predictive validity of admission criteria used by public dental colleges in Pakistan. Time to reconsider 巴基斯坦公立牙科学院入学标准预测效度的测量。是时候重新考虑了

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.028

Shahid Akhtar Akhund

Background/purpose

Dentistry education evolved from treating painful teeth to comprehensive oral care program. Oral health is an integral component of general healthcare. Like medical institutes, dental institutes have introduced admission tests as a component of selection criteria. However, various selection criteria components are not investigated for their predictive validity. This study aimed to measure the predictive value of selection criteria used in Pakistani dental colleges. This study provides recommendations for revision of weightings of admission criteria.

Materials and methods

This is a retrospective, quantitative and longitudinal cohort study. Deidentified data from a public dental college of Pakistan were analyzed. The Secondary School Certificate Examination (SSCE), Higher Secondary School Certificate Examination (HSSCE), and admission test scores were used as predictive variables, and professional examinations scores as outcome variables. Spearman's correlation coefficient and multivariate multiple regression (MMR) analyses were performed.

Results

Most data were left skewed, suggesting higher scores. The SSCE and admission test scores showed moderate positive correlation with professional examinations (P-values <0.001 to < 0.05). The R² values from 0.439 to 0.343, indicating a moderate to good amount of variance explained for each professional examination. The SSCE and admission test scores make a significant predictive model for all professional examinations.

Conclusion

The SSCE and admission test are the significant predictors of successful professional examinations. The Pakistan Medical and Dental Council (PMDC) should reconsider selection criteria weightings. A revised higher weighting for SSCE and admission test and lower weighting for HSSCE scores would bring fairness in the selection process.

背景/目的牙科教育从治疗牙痛发展到综合性口腔护理。口腔健康是一般保健的一个组成部分。与医疗机构一样，牙科机构也将入学考试作为选拔标准的一个组成部分。然而，各种选择标准的组成部分没有调查其预测效度。本研究旨在衡量巴基斯坦牙科院校使用的选择标准的预测价值。本研究为修订入学标准的权重提供了建议。材料与方法本研究为回顾性、定量、纵向队列研究。分析了巴基斯坦一所公立牙科学院的未识别数据。以中学毕业证书考试（SSCE）、高中毕业证书考试（HSSCE）和入学考试成绩作为预测变量，以专业考试成绩作为结果变量。采用Spearman相关系数和多变量回归（MMR）分析。结果大多数数据都是扭曲的，表明得分更高。SSCE和入学考试成绩与专业考试呈中度正相关（p值<；0.001 ~ < 0.05）。R2值从0.439到0.343，表明每个专业检查解释的方差适度到良好。SSCE和入学考试成绩是所有专业考试的重要预测模型。结论SSCE和入学考试是专业考试成功的重要预测因素。巴基斯坦医学和牙科理事会（PMDC）应重新考虑选择标准权重。提高SSCE和入学考试的权重，降低HSSCE分数的权重，将使选拔过程更加公平。

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引用次数: 0

Long non-coding RNA PP7080 enhances cancer stemness and tumorigenic features in oral cancer 长链非编码RNA PP7080增强口腔癌的癌干性和致瘤性特征

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.07.004

Chih-Yu Peng , Yu-Wei Chiu , Chun-Chung Huang , Po-Hsuan Tang , Fang-Yu Chang , Yi-Wen Liao , Cheng-Chia Yu , Shih-Min Wang

Background/purpose

Emerging evidence has shown that various failures in cancer therapy, such as drug resistance, metastasis, and cancer relapse are attributed to cancer stem cells (CSCs). Also, growing attention has been paid to the regulation of non-coding RNAs in cancer stemness. Here, we aimed to investigate the impact of lncRNA PP7080 on cancer stemness in oral squamous cell carcinomas.

Materials and methods

PP7080 expression was assessed in ALDH1⁺ and ALDH1^- cells sorted from oral squamous cell carcinoma cell lines using qRT-PCR. PP7080 was silenced in ALDH1⁺ SAS cells, and the effects on stemness characteristics, including ALDH1 activity, cell migration, colony formation, CD44 and Oct4 expression, and the expression of drug resistance-related markers ABCG2 and Bmi-1, were examined. The interaction between PP7080 and miR-601 was validated using a luciferase reporter assay. Rescue experiments were performed by inhibiting miR-601 in PP7080-silenced cells using apoptosis analysis. PP7080 expression in HNSCC was analyzed using the TCGA-HNSCC database.

Results

Our results showed that PP7080 was significantly overexpressed in oral cancer tissues and positively correlated with stemness markers. The phenotypic and flow cytometry assays demonstrated that suppression of PP7080 reduced the migratory and colony-forming aibilities, cancer stemness features, and self-renewal abilities in oral CSCs. Furthermore, we demonstrated that PP7080 may enhance cancer stemness features by counteracting the tumor-suppressive effect of miR-601.

Conclusion

Targeting PP7080 may offer a promising therapeutic strategy for oral cancer by reducing cancer stemness.

背景/目的越来越多的证据表明，癌症治疗的各种失败，如耐药、转移和癌症复发可归因于癌症干细胞（CSCs）。此外，非编码rna在肿瘤发生中的调控作用也越来越受到关注。在这里，我们的目的是研究lncRNA PP7080对口腔鳞状细胞癌的癌变的影响。材料与方法采用qRT-PCR技术检测口腔鳞癌细胞系ALDH1+和ALDH1-细胞中spp7080的表达。在ALDH1+ SAS细胞中沉默PP7080，检测其对ALDH1活性、细胞迁移、集落形成、CD44和Oct4表达以及耐药相关标志物ABCG2和Bmi-1表达等干细胞特性的影响。PP7080和miR-601之间的相互作用通过荧光素酶报告试验进行验证。通过凋亡分析，通过抑制pp7080沉默细胞中的miR-601进行挽救实验。使用TCGA-HNSCC数据库分析PP7080在HNSCC中的表达。结果PP7080在口腔癌组织中显著过表达，并与干性标志物正相关。表型和流式细胞术分析表明，PP7080的抑制降低了口腔csc的迁移和集落形成能力、癌性特征和自我更新能力。此外，我们证明PP7080可能通过抵消miR-601的肿瘤抑制作用来增强癌症干性特征。结论以PP7080为靶点，通过降低口腔癌的癌变程度，为口腔癌的治疗提供了一种有前景的治疗策略。

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引用次数: 0

Ovatodiolide overcomes cisplatin resistance in head and neck cancer by disrupting a novel oncogenic signature and cancer-associated fibroblast activation 卵泡内酯通过破坏一种新的致癌特征和癌症相关的成纤维细胞激活来克服头颈癌的顺铂耐药性

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.041

Chi-Hsueh Yang , Rachel Raditya Renantha , Po-Chih Hsu , Alexander TH. Wu , Szu-Yuan Wu , Nur Azizah , Ritmaleni Ritmaleni , Jia-Hong Chen , Jih-Chin Lee , Chih-Yuan Fang , Kuan-Chou Lin

Background/purpose

Malignant head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with complex tumor microenvironment interactions. We aimed to identify key molecular drivers and therapeutic targets using bioinformatics approaches and examine their associations with cancer-associated fibroblasts (CAF).

Materials and methods

We analyzed three HNSCC transcriptomic datasets using bioinformatics. Protein–protein interaction networks were created using STRING, and pathway enrichment was also performed. The clinical relevance and CAF association of genes were evaluated using the TCGA HNSCC cohort and TIMER 2.0. Molecular docking predicted ovatodiolide binding to target proteins. Bioinformatics findings were validated in HNSCC cell lines and normal fibroblasts (WS1) by assessing cell viability, tumor spheroid formation, and CAF transformation through viability assays, qPCR, and Western blot. A mouse model of cisplatin resistance was used to test ovatodiolide's therapeutic effect.

Results

Our bioinformatics identified a nine-gene oncogenic network in HNSCC enriched in inflammatory and profibrotic pathways. A core three-gene SIS oncogenic signature (SERPINE1, INHBA, SPP1) was identified. High SIS expression correlated with poor survival and increased CAF infiltration. Docking predicted favorable binding of ovatodiolide to SERPINE1, SPP1, and INHBA. CAF-conditioned medium enhanced the stemness and chemoresistance of HNSCC cells, promoting SIS signature and stemness markers. Ovatodiolide suppressed oncogenic properties and CAF activation, decreasing SIS and CAF markers. In a mouse model, ovatodiolide overcame cisplatin resistance by reducing the SIS signature.

Conclusion

The SIS signature contributes to HNSCC progression, stemness, and drug resistance by facilitating CAF generation. Ovatodiolide disrupts this signature and inhibits CAF transformation.

背景/目的：恶性头颈部鳞状细胞癌（HNSCC）是一种具有复杂肿瘤微环境相互作用的侵袭性癌症。我们的目的是利用生物信息学方法确定关键的分子驱动因素和治疗靶点，并研究它们与癌症相关成纤维细胞（CAF）的关联。材料与方法应用生物信息学方法对3个HNSCC转录组学数据集进行分析。使用STRING创建了蛋白-蛋白相互作用网络，并进行了途径富集。使用TCGA HNSCC队列和TIMER 2.0评估基因的临床相关性和CAF相关性。分子对接预测卵泡内酯与靶蛋白结合。生物信息学研究结果在HNSCC细胞系和正常成纤维细胞（WS1）中得到验证，方法是通过细胞活力测定、qPCR和Western blot来评估细胞活力、肿瘤球体形成和CAF转化。采用小鼠顺铂耐药模型，观察卵泡内酯的治疗效果。结果我们的生物信息学在HNSCC中发现了一个富含炎症和纤维化途径的9基因致癌网络。鉴定出一个核心的三基因SIS致癌特征（SERPINE1， INHBA, SPP1）。高SIS表达与生存差和CAF浸润增加相关。对接预测卵泡二内酯与SERPINE1、SPP1和INHBA的良好结合。ca条件培养基增强了HNSCC细胞的干性和化学抗性，促进了SIS特征和干性标记。卵黄内酯抑制致癌特性和CAF激活，降低SIS和CAF标记物。在小鼠模型中，卵泡内酯通过降低SIS特征克服了顺铂耐药性。结论SIS特征通过促进CAF的产生，促进了HNSCC的进展、干性和耐药。卵泡内酯破坏这一特征并抑制CAF转化。

{"title":"Ovatodiolide overcomes cisplatin resistance in head and neck cancer by disrupting a novel oncogenic signature and cancer-associated fibroblast activation","authors":"Chi-Hsueh Yang , Rachel Raditya Renantha , Po-Chih Hsu , Alexander TH. Wu , Szu-Yuan Wu , Nur Azizah , Ritmaleni Ritmaleni , Jia-Hong Chen , Jih-Chin Lee , Chih-Yuan Fang , Kuan-Chou Lin","doi":"10.1016/j.jds.2025.08.041","DOIUrl":"10.1016/j.jds.2025.08.041","url":null,"abstract":"<div><h3>Background/purpose</h3><div>Malignant head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with complex tumor microenvironment interactions. We aimed to identify key molecular drivers and therapeutic targets using bioinformatics approaches and examine their associations with cancer-associated fibroblasts (CAF).</div></div><div><h3>Materials and methods</h3><div>We analyzed three HNSCC transcriptomic datasets using bioinformatics. Protein–protein interaction networks were created using STRING, and pathway enrichment was also performed. The clinical relevance and CAF association of genes were evaluated using the TCGA HNSCC cohort and TIMER 2.0. Molecular docking predicted ovatodiolide binding to target proteins. Bioinformatics findings were validated in HNSCC cell lines and normal fibroblasts (WS1) by assessing cell viability, tumor spheroid formation, and CAF transformation through viability assays, qPCR, and Western blot. A mouse model of cisplatin resistance was used to test ovatodiolide's therapeutic effect.</div></div><div><h3>Results</h3><div>Our bioinformatics identified a nine-gene oncogenic network in HNSCC enriched in inflammatory and profibrotic pathways. A core three-gene SIS oncogenic signature (SERPINE1, INHBA, SPP1) was identified. High SIS expression correlated with poor survival and increased CAF infiltration. Docking predicted favorable binding of ovatodiolide to SERPINE1, SPP1, and INHBA. CAF-conditioned medium enhanced the stemness and chemoresistance of HNSCC cells, promoting SIS signature and stemness markers. Ovatodiolide suppressed oncogenic properties and CAF activation, decreasing SIS and CAF markers. In a mouse model, ovatodiolide overcame cisplatin resistance by reducing the SIS signature.</div></div><div><h3>Conclusion</h3><div>The SIS signature contributes to HNSCC progression, stemness, and drug resistance by facilitating CAF generation. Ovatodiolide disrupts this signature and inhibits CAF transformation.</div></div>","PeriodicalId":15583,"journal":{"name":"Journal of Dental Sciences","volume":"21 1","pages":"Pages 282-293"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful non-surgical repair of a large furcal perforation using endodontic biomaterials: A case report of 30-month follow-up 根管生物材料成功修复大分叉穿孔1例，随访30个月

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.09.006

Saeed Asgary

引用次数: 0

Furcation-involved class II subclass B molar treated by Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under a microscope: A case report 显微镜下Er:YAG激光辅助综合牙周袋治疗ⅱ亚类B磨牙功能受损1例

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.017

Taichen Lin, Min Yee Ng, Yoichi Taniguchi, Akira Aoki

引用次数: 0

Rethinking English medium instruction for dental education in Taiwan 台湾牙科教育英语教学的再思考

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.013

Ching-Shuen Wang , Feng-Chou Cheng , Wei-Chun Lin, Chun-Pin Chiang

引用次数: 0

Pleomorphic adenoma with extensive squamous metaplasia - A case report 多形性腺瘤伴广泛鳞状化生1例

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.016

Hung-Pin Lin, Chun-Pin Chiang

引用次数: 0

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