Journal of Dental Sciences最新文献

英文中文

Laser-modified titanium surfaces induce sex-dimorphic secretion of angiogenic factors by gingiva-derived mesenchymal stromal cells 激光修饰钛表面诱导牙龈源性间充质间质细胞分泌血管生成因子

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.09.013

Ting-Han Chang , Hsin-Han Hou , Yi-Shing Shieh , Her-Hsiung Huang , Da-Yo Yuh

Background/purpose

Dental implants have been applied to restore missing dentition for more than fifty years. However, whether different surface modification on implant provide topographical cues that alter sex-specific effect on peri-implant angiogenesis remains unclear. This study aimed to investigate whether titanium surface modifications influence sex-specific chromatin accessibility, gene expression, and angiogenesis-related functions in human gingiva-derived mesenchymal stromal cells (GMSCs).

Materials and methods

We collected health gingival tissues from sixteen subjects (eight females and eight males) and isolated primary GMSCs. The primary GMSCs were cultured on three types of titanium surfaces: machined, lasered, and SLA (sand-blasted, large-grit, acid-etched). Chromatin accessibility and gene expression were assessed via ATAC-seq and RNA-seq, respectively, with further validation through qRT-PCR, ELISA, and western blot. Functional angiogenic potential was evaluated using both direct and indirect tube formation assays.

Results

Our findings revealed that titanium surface modifications induce sex-dimorphic effects on the secretion of angiogenic factors CCN1 and EDIL3. Laser-modified titanium significantly increased the secretion of extracellular vesicles enriched with both CCN1 and EDIL3 compared to machined surfaces. Interestingly, female GMSCs secreted higher levels of EDIL3, while male GMSCs secreted more CCN1 on lasered titanium surfaces. Moreover, lasered titanium demonstrated superior angiogenic potential in both direct and indirect tube formation assays compared with machined and SLA titanium.

Conclusion

This study suggests that laser-modified microchannels on titanium surfaces provide bioactive topographical cues that enhance the secretion of extracellular vesicles enriched with angiogenic factors—particularly CCN1 and EDIL3—by GMSCs, which may play key roles in promoting angiogenesis and supporting early-stage osseointegration.

背景/目的牙种植体用于修复缺失牙列已有50多年的历史。然而，不同的种植体表面修饰是否提供了改变种植体周围血管生成的性别特异性效应的地形线索尚不清楚。本研究旨在探讨钛表面修饰是否影响人牙龈源性间充质间质细胞（GMSCs）的性别特异性染色质可及性、基因表达和血管生成相关功能。材料和方法我们收集了16名受试者（男女各8名）的健康牙龈组织，并分离了原代GMSCs。原代GMSCs在三种钛表面培养：机械、激光和SLA（喷砂、大粒度、酸蚀）。分别通过ATAC-seq和RNA-seq评估染色质可及性和基因表达，并通过qRT-PCR、ELISA和western blot进一步验证。使用直接和间接的血管形成试验来评估功能性血管生成潜力。结果钛表面修饰可诱导血管生成因子CCN1和EDIL3分泌的性别二态效应。与加工表面相比，激光修饰钛显著增加了富含CCN1和EDIL3的细胞外囊泡的分泌。有趣的是，雌性GMSCs分泌更高水平的EDIL3，而雄性GMSCs在激光钛表面分泌更多的CCN1。此外，与机械钛和SLA钛相比，激光钛在直接和间接的血管生成实验中都表现出优越的血管生成潜力。结论激光修饰的钛表面微通道提供了生物活性的地形线索，可促进GMSCs分泌富含血管生成因子（特别是CCN1和edil3）的细胞外囊泡，这可能在促进血管生成和支持早期骨整合中发挥关键作用。

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引用次数: 0

Adjuvant metronomic tegafur-uracil is associated with poorer outcomes and unfavorable histopathologic progression in oral squamous cell carcinomas 辅助节拍剂替加福-尿嘧啶与口腔鳞状细胞癌较差的预后和不利的组织病理学进展有关

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.023

Kai-Feng Hung , Yi-Ping Wang , Yi-Chen Sun , Zhi-Qian Lin , Cheng-Hsien Wu , Peter Mu-Hsin Chang , Julia Yu-Fong Chang

Background/purpose

Tegafur-uracil (UFUR) is widely prescribed as metronomic adjuvant chemotherapy for oral squamous cell carcinoma (OSCC) in East Asia, though its long-term benefit remains unclear. This study aimed to evaluate the oncologic and pathological impact of adjuvant UFUR in a large real-world OSCC cohort spanning three decades.

Materials and methods

This retrospective, single-institution cohort included 2048 patients with histopathologically confirmed OSCC treated at a tertiary medical center in Taiwan (1990–2020). All underwent curative-intent surgery with or without postoperative radiotherapy or concurrent chemoradiotherapy (CCRT). Among them, 878 patients received adjuvant metronomic UFUR for ≥12 months. Survival outcomes were analyzed using Kaplan–Meier and Cox proportional hazards models, and clinicopathologic associations were assessed using chi-square and Wilcoxon tests.

Results

Adjuvant UFUR did not improve disease-free survival (DFS) across cancer stages and was associated with significantly poorer DFS in early-stage diseases. Hazard ratios (HRs) for DFS in stages I–III were 1.523, 1.616, and 1.441, respectively (all P < 0.01). UFUR-treated patients also exhibited higher rates of recurrence, earlier onset of second primary cancers, and more frequent spindle-cell transformation, particularly among poorly-differentiated OSCCs.

Conclusion

Adjuvant metronomic UFUR provided no survival advantage and was associated with unfavorable histopathologic evolution in OSCCs. These findings warrant re-evaluation of UFUR as routine adjuvant therapy and support risk-adapted, molecularly guided postoperative strategies in oral cancer management.

背景/目的替加富-尿嘧啶（UFUR）在东亚地区被广泛用作口腔鳞状细胞癌（OSCC）的节律辅助化疗，但其长期疗效尚不清楚。本研究旨在评估辅助UFUR在30年真实世界大型OSCC队列中的肿瘤学和病理学影响。材料与方法本回顾性单机构队列研究纳入了2048例在台湾某三级医疗中心接受组织病理学证实的OSCC患者（1990-2020）。所有患者均接受了有或无术后放疗或同步放化疗（CCRT）的治疗目的手术。其中878例患者接受辅助节律性UFUR治疗≥12个月。使用Kaplan-Meier和Cox比例风险模型分析生存结果，使用卡方检验和Wilcoxon检验评估临床病理相关性。结果佐剂UFUR并没有改善癌症分期的无病生存（DFS），并且与早期疾病的无病生存（DFS）显著降低相关。I-III期DFS的风险比（hr）分别为1.523、1.616和1.441 （P均为0.01）。ufu治疗的患者也表现出更高的复发率，第二原发癌发病更早，纺锤细胞转化更频繁，特别是在低分化的OSCCs中。结论辅助节律性UFUR在OSCCs中没有生存优势，并与不利的组织病理演变有关。这些发现支持重新评估UFUR作为常规辅助治疗，并支持风险适应，分子指导的口腔癌术后治疗策略。

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引用次数: 0

Collaborative care for children's oral and holistic health among physicians and dentists in Taiwan 台湾医师与牙医对儿童口腔与整体健康的合作照护

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.10.001

Feng-Chou Cheng , Ling-Hsia Wang , Yin-Lin Wang, Chun-Pin Chiang

引用次数: 0

Bio-obturation of a large perforated internal root resorption: A case report 生物封闭大穿孔内根吸收1例报告

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.08.043

Saeed Asgary

引用次数: 0

Impact of female hormonal changes throughout life on oral health: A scoping review 一生中女性荷尔蒙变化对口腔健康的影响：范围综述

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.09.016

Inês Lopes Cardoso , Mayane Fryde , Maria Inês Guimarães , Fernanda Leal

This work looks at the impact of female hormonal fluctuations throughout life, during puberty, pregnancy and the menopause, on oral health. These physiological periods, marked by major variations in estrogen and progesterone levels, influence oral health, so the following question was formulated: to what extent do female hormonal fluctuations influence oral health? Through a scoping review of 37 scientific articles selected using a rigorous methodology (in particular using the Rayyan tool), it was possible to highlight clinical manifestations specific to each hormonal stage. In adolescent girls, puberty is frequently accompanied by exacerbated gingivitis, independent of dental plaque. During pregnancy, the increase in hormones leads to increased gingival inflammation and transient tooth mobility. Finally, the menopause is associated with a drop in female sex hormones, which can lead to dry mouth, altered salivary flora and accelerated bone loss, all of which contribute to the worsening of periodontal disease. These results underline the importance of a preventive and personalized approach to oral health care for patients, taking into account the hormonal context. They also highlight the collaboration between dentists, general practitioners and gynecologists, to optimize comprehensive care for women at every stage of their hormonal life.

这项研究着眼于女性荷尔蒙波动对口腔健康的影响，包括青春期、孕期和更年期。这些生理时期，以雌激素和黄体酮水平的主要变化为标志，影响口腔健康，因此提出了以下问题：女性荷尔蒙波动在多大程度上影响口腔健康？通过使用严格的方法（特别是使用Rayyan工具）对37篇科学文章进行范围审查，有可能突出每个激素阶段特有的临床表现。在青春期女孩中，青春期经常伴有牙龈炎的加重，与牙菌斑无关。在怀孕期间，荷尔蒙的增加会导致牙龈发炎和短暂的牙齿活动。最后，更年期与女性性激素下降有关，这会导致口干、唾液菌群改变和骨质流失加速，所有这些都会导致牙周病的恶化。这些结果强调了预防和个性化的方法对患者口腔保健的重要性，考虑到激素的背景。他们还强调了牙医、全科医生和妇科医生之间的合作，以优化妇女在荷尔蒙生活的每个阶段的综合护理。

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引用次数: 0

Clinical decision support of advanced large language models in endodontic disease 高级大语言模型在牙髓疾病中的临床决策支持

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.06.007

Jiahe Li , Xian He , Yong Wang , Yanan Liu , Jie Liu , Mingxiao Liu , Tianyu Huang , Zeyu Huang

Background/purpose

Large language models (LLMs) exhibit significant potential for clinical decision support, yet their application in endodontic disease remains underexplored.

Materials and methods

This study assessed the decision-making capabilities of three advanced LLMs (GPT-4o, Claude 3.5, and Grok2) in specialized endodontic contexts. A question bank of 421 multiple-choice questions was constructed across 27 core endodontic topics, including theory, procedures, and 35 complex cases. The three LLMs were tested using standardized prompts, with performance evaluated via topic-stratified accuracy analysis.

Results

Claude 3.5 achieved the highest overall accuracy (73.39 %), followed by Grok2 (66.27 %) and GPT-4o (46.32 %). Grok2 excelled in complex case analysis (69.57 %). The models performed strongly in theoretical domains (e.g., clinical examination, structural function, pharmacology) but showed limitations in complex scenarios and procedural techniques.

Conclusion

LLMs hold promise as endodontic decision support tools, though domain-specific refinement is essential for effective clinical application.

背景/目的大型语言模型（LLMs）在临床决策支持方面显示出巨大的潜力，但它们在牙髓疾病中的应用仍未得到充分探索。材料和方法本研究评估了三种高级LLMs （gpt - 40, Claude 3.5和Grok2）在专业牙髓环境下的决策能力。题目库包含421道选择题，涉及27个牙髓学核心主题，包括理论、程序和35个复杂案例。三个llm使用标准化提示进行测试，并通过主题分层准确性分析评估性能。结果claude 3.5的总体准确率最高（73.39%），其次是Grok2（66.27%）和gpt - 40（46.32%）。Grok2在复杂病例分析方面表现突出（69.57%）。这些模型在理论领域（如临床检查、结构功能、药理学）表现良好，但在复杂场景和程序技术方面存在局限性。结论llm作为牙髓学决策支持工具具有良好的前景，但针对特定领域的改进对于有效的临床应用至关重要。

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引用次数: 0

A scientometric study on research trends and characteristics of mucoepidermoid carcinoma of salivary glands 唾液腺黏液表皮样癌研究趋势及特点的科学计量学研究

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences

Pub Date : 2026-01-01 DOI: 10.1016/j.jds.2025.07.027

Xiuyin Wu , Yawen Ji , Ke Bi , Zhen Wang , Meili Sun

Background/purpose

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. The purpose of this study was to analyze the scientometric characteristics and research trends of salivary MEC.

Materials and methods

All the papers on salivary MEC were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2014 and Jan 2014–Jun 2025 in the analysis of research trends.

Results

There were 1308 papers on salivary MEC, with total citations of 24,598 and the h index of 70. The most frequent location of MEC involved was parotid gland, followed by minor saliva gland and submandibular gland. The keywords of differential diagnosis included adenosquamous carcinoma, pleomorphic adenoma, squamous cell carcinoma, Warthin tumor, and adenoid cystic carcinoma. Cancer surgery, radiotherapy, parotidectomy, neck dissection, chemotherapy, and cisplatin were the keywords of treatment. The research trend of has changed to cohort analysis, cancer prognosis, diagnostic imaging, positron emission tomography-computed tomography (PET-CT), perineural invasion, p63, gene mutation, gene rearrangement, and gene translocation after 2014. There have always been the common keywords such as pathology, tumor marker, immunohistochemistry, Ki-67, CRTC1, MAML2, gene fusion, and fluorescence in situ hybridization (FISH).

Conclusion

This study for the first time elucidated the current scenario and scientometric characteristics of MEC, and would help in improving in reciprocal collaboration and provide helpful guidance for further research.

背景/目的涎腺上皮样癌（MEC）是唾液腺最常见的恶性肿瘤。本研究的目的是分析唾液MEC的科学计量学特征和研究趋势。材料与方法从Scopus数据库中综合检索唾液MEC相关文献。在研究趋势分析中，将发表年份分为2014年以前和2014年1月- 2025年6月。结果共收录唾液MEC相关论文1308篇，总被引24598次，h指数为70。最常见的受累部位为腮腺，其次为小涎腺和下颌下腺。鉴别诊断关键词：腺鳞癌、多形性腺瘤、鳞状细胞癌、沃辛瘤、腺样囊性癌。肿瘤手术、放疗、腮腺切除术、颈部清扫、化疗、顺铂是治疗的关键词。2014年以后，研究趋势转变为队列分析、肿瘤预后、诊断影像、正电子发射断层扫描-计算机断层扫描（PET-CT）、神经周围侵袭、p63、基因突变、基因重排、基因易位。病理学、肿瘤标志物、免疫组织化学、Ki-67、CRTC1、MAML2、基因融合、荧光原位杂交（FISH）等常用关键词一直存在。结论本研究首次阐明了MEC的现状和科学计量学特征，有助于加强相互协作，为进一步的研究提供有益的指导。

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