Pub Date : 2025-01-29DOI: 10.1038/s41370-024-00740-4
Simone Stefano, Alessia Lanno, Sofia Ghironi, Alice Passoni, Renzo Bagnati, Alessandra Roncaglioni, Enrico Davoli, Elena Fattore
The Observed Individual Means (OIM) methodology, based on the non-parametric bootstrap, is usually employed to perform basic probabilistic dietary chronic exposure assessment, and assumes independence and identical distribution of occurrence data within food category. However, this assumption may not be valid if several expected distributions of occurrence can be a priori identified within food category. Moreover, OIM assumes each analysed food sample to equally contribute to mean occurrence, as information about relevance of each food item cannot be incorporated into exposure assessment. In this paper we address the above-mentioned violations and develop two statistical methodologies to accommodate for them into OIM. The stratified non-parametric bootstrap and weighted mean occurrence are employed to correct for such violations. As a case study, we compare the methodologies by estimating the exposure of the adult Italian population to the process contaminant 3-monochloropropane-1,2-diol. We propose strategies to interpret their results and show their relevance in conducting exposure assessment. For the first time in the literature, we critically examine a widely used methodology for Probabilistic Dietary Exposure Assessment from a statistical perspective, focusing on the underlying assumptions and their potential violations in real-world scenarios. We then develop techniques to address these violations, providing a more accurate and robust approach to exposure assessment. This work is particularly relevant for risk assessors and managers, since it offers a refined toolset for more precise exposure assessments.
{"title":"Refined methodologies for probabilistic dietary exposure assessment for food contaminants based on the observed individual means methodology","authors":"Simone Stefano, Alessia Lanno, Sofia Ghironi, Alice Passoni, Renzo Bagnati, Alessandra Roncaglioni, Enrico Davoli, Elena Fattore","doi":"10.1038/s41370-024-00740-4","DOIUrl":"10.1038/s41370-024-00740-4","url":null,"abstract":"The Observed Individual Means (OIM) methodology, based on the non-parametric bootstrap, is usually employed to perform basic probabilistic dietary chronic exposure assessment, and assumes independence and identical distribution of occurrence data within food category. However, this assumption may not be valid if several expected distributions of occurrence can be a priori identified within food category. Moreover, OIM assumes each analysed food sample to equally contribute to mean occurrence, as information about relevance of each food item cannot be incorporated into exposure assessment. In this paper we address the above-mentioned violations and develop two statistical methodologies to accommodate for them into OIM. The stratified non-parametric bootstrap and weighted mean occurrence are employed to correct for such violations. As a case study, we compare the methodologies by estimating the exposure of the adult Italian population to the process contaminant 3-monochloropropane-1,2-diol. We propose strategies to interpret their results and show their relevance in conducting exposure assessment. For the first time in the literature, we critically examine a widely used methodology for Probabilistic Dietary Exposure Assessment from a statistical perspective, focusing on the underlying assumptions and their potential violations in real-world scenarios. We then develop techniques to address these violations, providing a more accurate and robust approach to exposure assessment. This work is particularly relevant for risk assessors and managers, since it offers a refined toolset for more precise exposure assessments.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 3","pages":"375-381"},"PeriodicalIF":4.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-28DOI: 10.1038/s41370-025-00752-8
I-Chen Chen
{"title":"marlod: an R package to model environmental exposure and biomonitoring data with repeated measurements and values below the limit of detection","authors":"I-Chen Chen","doi":"10.1038/s41370-025-00752-8","DOIUrl":"10.1038/s41370-025-00752-8","url":null,"abstract":"","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 4","pages":"630-631"},"PeriodicalIF":4.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-25DOI: 10.1038/s41370-025-00744-8
Lauren A. Eaves, Evans K. Lodge, Wendy R. Rohin, Kyle R. Roell, Tracy A. Manuck, Rebecca C. Fry
Preterm birth (PTB) is a common pregnancy complication associated with significant neonatal morbidity. Prenatal exposure to environmental chemicals, including toxic and/or essential metal(loid)s, may contribute to PTB risk. We aimed to summarize the epidemiologic evidence of the associations among levels of arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), lead (Pb), and zinc (Zn) assessed during the prenatal period and PTB or gestational age at delivery; to assess the quality of the literature and strength of evidence for an effect for each metal; and to provide recommendations for future research. We adapted the Navigation Guide methodology and followed PRISMA guidelines. We searched the MEDLINE/PubMed database for epidemiologic studies from 1995 to 2023. We used a customized risk of bias protocol and evaluated the sufficiency of evidence for an effect of each metal(loid) on PTB risk. A total of 1206 studies were identified and screened. Of these, 139 were assessed for eligibility by reading the full-text, and 92 studies were ultimately included (arsenic: 40, cadmium: 30, chromium: 11, copper: 21, mercury: 27, manganese: 17, lead: 41, zinc: 18, metal(loid) mixtures: 12). We found sufficient evidence that lead increases the risk of PTB and, while the evidence was limited, suggestive evidence that cadmium and chromium increase the risk of PTB. The evidence was deemed inadequate to determine an effect for the other metal(loid)s. Future research would benefit from more precise PTB clinical phenotyping, measuring exposure early and longitudinally throughout pregnancy, using an appropriate media for metal(loid)s under study, and evaluating metal mixtures. Given the strength of evidence linking lead exposure and PTB, active and comprehensive prenatal screening for lead exposure among pregnant individuals is warranted.
{"title":"Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence","authors":"Lauren A. Eaves, Evans K. Lodge, Wendy R. Rohin, Kyle R. Roell, Tracy A. Manuck, Rebecca C. Fry","doi":"10.1038/s41370-025-00744-8","DOIUrl":"10.1038/s41370-025-00744-8","url":null,"abstract":"Preterm birth (PTB) is a common pregnancy complication associated with significant neonatal morbidity. Prenatal exposure to environmental chemicals, including toxic and/or essential metal(loid)s, may contribute to PTB risk. We aimed to summarize the epidemiologic evidence of the associations among levels of arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), lead (Pb), and zinc (Zn) assessed during the prenatal period and PTB or gestational age at delivery; to assess the quality of the literature and strength of evidence for an effect for each metal; and to provide recommendations for future research. We adapted the Navigation Guide methodology and followed PRISMA guidelines. We searched the MEDLINE/PubMed database for epidemiologic studies from 1995 to 2023. We used a customized risk of bias protocol and evaluated the sufficiency of evidence for an effect of each metal(loid) on PTB risk. A total of 1206 studies were identified and screened. Of these, 139 were assessed for eligibility by reading the full-text, and 92 studies were ultimately included (arsenic: 40, cadmium: 30, chromium: 11, copper: 21, mercury: 27, manganese: 17, lead: 41, zinc: 18, metal(loid) mixtures: 12). We found sufficient evidence that lead increases the risk of PTB and, while the evidence was limited, suggestive evidence that cadmium and chromium increase the risk of PTB. The evidence was deemed inadequate to determine an effect for the other metal(loid)s. Future research would benefit from more precise PTB clinical phenotyping, measuring exposure early and longitudinally throughout pregnancy, using an appropriate media for metal(loid)s under study, and evaluating metal mixtures. Given the strength of evidence linking lead exposure and PTB, active and comprehensive prenatal screening for lead exposure among pregnant individuals is warranted.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 5","pages":"696-708"},"PeriodicalIF":4.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41370-025-00744-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1038/s41370-025-00746-6
Lia Visintin, En-Hsuan Lu, Hsing-Chieh Lin, Yasmine Bader, Truong Nhat Nguyen, Thanos Mouchtaris Michailidis, Sarah De Saeger, Weihsueh A. Chiu, Marthe De Boevre
Tenuazonic acid (TeA), a mycotoxin produced by Alternaria alternata, contaminates various food commodities and is known to cause acute and chronic health effects. However, the lack of human toxicokinetic (TK) data and the reliance on external exposure estimates have stalled a comprehensive risk assessment for TeA. To bridge this gap, a human TK trial and population-based TK (PopTK) modeling were applied to determine human TK parameters of TeA, and the results were applied for risk screening using population biomonitoring data and threshold of toxicological concern (TTC)-based approaches. Ten healthy volunteers participated in the TK trial during which the volunteers ingested a bolus dose of TeA at the (external) TTC (1500 ng/kg bw). Blood, urine, and fecal samples were collected over 48 h and analyzed using UPLC-MS/MS. Concentration-time profiles were fit with a multi-compartmental PopTK model using a hierarchical Bayesian population structure. Utilizing a probabilistic framework, fitted TK parameters were used to derive internal TTC (iTTC) values for comparison to blood and urine biomonitoring data. Risk screening with data from five diverse biomonitoring cohorts was performed using Hazard Quotient (HQ) and probabilistic individual margin of exposure (IMOE) approaches. TeA was estimated to have a population median half-life of 1.9 [90% CI: 1.4–2.7] hours and volume of distribution of 4.4 [3.1–6.1] L/kg, with inter-individual variability geometric standard deviations of 2.4- and 1.7-fold, respectively. Probabilistic lower confidence bound iTTCs were derived of 0.5 nmol/L in blood and 2.53 nmol/kg-d urinary excretion. Risk screening HQs were mostly >1 for the three blood biomonitoring cohorts and < 1 for the two urinary biomonitoring cohorts; results from probabilistic IMOE calculations were qualitatively consistent. A comprehensive human TK study was performed for TeA for the first time, demonstrating the importance of integrating TK and population variability for a more comprehensive risk evaluation, particularly for interpreting biomonitoring data. The results for TeA point to the critical need for toxicity data to move beyond TTC-based risk screening.
{"title":"Derivation of human toxicokinetic parameters and internal threshold of toxicological concern for tenuazonic acid through a human intervention trial and hierarchical Bayesian population modeling","authors":"Lia Visintin, En-Hsuan Lu, Hsing-Chieh Lin, Yasmine Bader, Truong Nhat Nguyen, Thanos Mouchtaris Michailidis, Sarah De Saeger, Weihsueh A. Chiu, Marthe De Boevre","doi":"10.1038/s41370-025-00746-6","DOIUrl":"10.1038/s41370-025-00746-6","url":null,"abstract":"Tenuazonic acid (TeA), a mycotoxin produced by Alternaria alternata, contaminates various food commodities and is known to cause acute and chronic health effects. However, the lack of human toxicokinetic (TK) data and the reliance on external exposure estimates have stalled a comprehensive risk assessment for TeA. To bridge this gap, a human TK trial and population-based TK (PopTK) modeling were applied to determine human TK parameters of TeA, and the results were applied for risk screening using population biomonitoring data and threshold of toxicological concern (TTC)-based approaches. Ten healthy volunteers participated in the TK trial during which the volunteers ingested a bolus dose of TeA at the (external) TTC (1500 ng/kg bw). Blood, urine, and fecal samples were collected over 48 h and analyzed using UPLC-MS/MS. Concentration-time profiles were fit with a multi-compartmental PopTK model using a hierarchical Bayesian population structure. Utilizing a probabilistic framework, fitted TK parameters were used to derive internal TTC (iTTC) values for comparison to blood and urine biomonitoring data. Risk screening with data from five diverse biomonitoring cohorts was performed using Hazard Quotient (HQ) and probabilistic individual margin of exposure (IMOE) approaches. TeA was estimated to have a population median half-life of 1.9 [90% CI: 1.4–2.7] hours and volume of distribution of 4.4 [3.1–6.1] L/kg, with inter-individual variability geometric standard deviations of 2.4- and 1.7-fold, respectively. Probabilistic lower confidence bound iTTCs were derived of 0.5 nmol/L in blood and 2.53 nmol/kg-d urinary excretion. Risk screening HQs were mostly >1 for the three blood biomonitoring cohorts and < 1 for the two urinary biomonitoring cohorts; results from probabilistic IMOE calculations were qualitatively consistent. A comprehensive human TK study was performed for TeA for the first time, demonstrating the importance of integrating TK and population variability for a more comprehensive risk evaluation, particularly for interpreting biomonitoring data. The results for TeA point to the critical need for toxicity data to move beyond TTC-based risk screening.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 4","pages":"632-643"},"PeriodicalIF":4.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-20DOI: 10.1038/s41370-025-00747-5
Weihsueh A. Chiu, Galen Newman, Garett Sansom, Xinyue Ye, Andriy Rusyn, Haotian Wu, Tom Winckelman, Ivan Rusyn
Many chemical releases are first noticed by community members, but reporting these concerns often involves considerable hurdles. Artificial Intelligence (AI)-enabled technologies, especially large language models (LLMs), can potentially reduce these barriers. We hypothesized that AI-powered chatbots can facilitate reporting of pollution incidents through text messaging. We created an AI-powered chatbot, “MyEcoReporter,” that enables communities to report environmental incidents to government authorities. Eschewing traditional web-based forms, users text concerns via SMS to the LLM-powered application, engaging in a natural conversation through which required information is collected. The application was built using Python, AWS Lambda, DynamoDB, and Twilio, and deployed via Serverless. This architecture allowed rapid customization for various use cases, which successfully facilitated conversations and stored structured data for formal submission. MyEcoReporter showcases the potential of Artificial Intelligence/Large Language Models to create user-friendly tools that translate community environmental concerns into actionable information for reporting to government authorities.
{"title":"MyEcoReporter: a prototype for artificial intelligence-facilitated pollution reporting","authors":"Weihsueh A. Chiu, Galen Newman, Garett Sansom, Xinyue Ye, Andriy Rusyn, Haotian Wu, Tom Winckelman, Ivan Rusyn","doi":"10.1038/s41370-025-00747-5","DOIUrl":"10.1038/s41370-025-00747-5","url":null,"abstract":"Many chemical releases are first noticed by community members, but reporting these concerns often involves considerable hurdles. Artificial Intelligence (AI)-enabled technologies, especially large language models (LLMs), can potentially reduce these barriers. We hypothesized that AI-powered chatbots can facilitate reporting of pollution incidents through text messaging. We created an AI-powered chatbot, “MyEcoReporter,” that enables communities to report environmental incidents to government authorities. Eschewing traditional web-based forms, users text concerns via SMS to the LLM-powered application, engaging in a natural conversation through which required information is collected. The application was built using Python, AWS Lambda, DynamoDB, and Twilio, and deployed via Serverless. This architecture allowed rapid customization for various use cases, which successfully facilitated conversations and stored structured data for formal submission. MyEcoReporter showcases the potential of Artificial Intelligence/Large Language Models to create user-friendly tools that translate community environmental concerns into actionable information for reporting to government authorities.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 3","pages":"325-329"},"PeriodicalIF":4.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-14DOI: 10.1038/s41370-025-00745-7
Dylan Wood, Dimitris Evangelopoulos, Nutthida Kitwiroon, Gregor Stewart, Tuan Vu, James Smith, Sean Beevers, Klea Katsouyanni
Accurate estimates of personal exposure to ambient air pollution are difficult to obtain and epidemiological studies generally rely on residence-based estimates, averaged spatially and temporally, derived from monitoring networks or models. Few epidemiological studies have compared the associated health effects of personal exposure and residence-based estimates. To evaluate the association between exposure to air pollution and cognitive function using exposure estimates taking mobility and location into account. Residence-based dispersion model estimates of ambient NO2, PM10 and PM2.5 were assigned to 768 London-dwelling participants of the English Longitudinal Study of Ageing. The London Hybrid Exposure Model was implemented to adjust estimates per pollutant to reflect the estimated time-activity patterns of each participant based on age and residential location. Single pollutant linear mixed-effects models were fit for both exposure assessment methods to investigate the associations between assigned pollutant concentrations and cognitive function over a follow-up period of up to 15 years. Increased long-term exposures to residence-based ambient NO2 (IQR: 11.10 µg/m3), PM10 (2.35 µg/m3), and PM2.5 (2.50 µg/m3) were associated with decreases of −0.10 [95% CI: −0.20, 0.00], −0.07 [−0.11, −0.02] and −0.14 [−0.21, −0.06], respectively, in composite memory score. Similar decreases were observed for executive function scores (−0.38 [−0.58, −0.18], −0.11 [−0.20, −0.02] and −0.14 [−0.29, 0.01], respectively). When applying personalised exposure estimates, which were substantially lower, similar decreases were observed for composite memory score per IQR, but a consistent pattern of slightly more adverse effects with executive function score was evident. The present study constructed a framework through which time-activity information derived from a representative sample could be applied to estimates of ambient air pollution concentrations assigned to individuals in epidemiological cohort studies, with the intention of adjusting commonly used residence-based estimates to reflect population mobility and time spent in various microenvironments. Estimates of exposure were markedly lower when incorporating time-activity, likely because people in European populations spend a large proportion of their time indoors, where their exposure to ambient air pollution may be reduced through infiltration, which is not taken into account in residence-based ambient estimates. Further work into such methods could provide insights into the efficacy of personalising exposure estimates.
{"title":"Personalised estimation of exposure to ambient air pollution and application in a longitudinal cohort analysis of cognitive function in London-dwelling older adults","authors":"Dylan Wood, Dimitris Evangelopoulos, Nutthida Kitwiroon, Gregor Stewart, Tuan Vu, James Smith, Sean Beevers, Klea Katsouyanni","doi":"10.1038/s41370-025-00745-7","DOIUrl":"10.1038/s41370-025-00745-7","url":null,"abstract":"Accurate estimates of personal exposure to ambient air pollution are difficult to obtain and epidemiological studies generally rely on residence-based estimates, averaged spatially and temporally, derived from monitoring networks or models. Few epidemiological studies have compared the associated health effects of personal exposure and residence-based estimates. To evaluate the association between exposure to air pollution and cognitive function using exposure estimates taking mobility and location into account. Residence-based dispersion model estimates of ambient NO2, PM10 and PM2.5 were assigned to 768 London-dwelling participants of the English Longitudinal Study of Ageing. The London Hybrid Exposure Model was implemented to adjust estimates per pollutant to reflect the estimated time-activity patterns of each participant based on age and residential location. Single pollutant linear mixed-effects models were fit for both exposure assessment methods to investigate the associations between assigned pollutant concentrations and cognitive function over a follow-up period of up to 15 years. Increased long-term exposures to residence-based ambient NO2 (IQR: 11.10 µg/m3), PM10 (2.35 µg/m3), and PM2.5 (2.50 µg/m3) were associated with decreases of −0.10 [95% CI: −0.20, 0.00], −0.07 [−0.11, −0.02] and −0.14 [−0.21, −0.06], respectively, in composite memory score. Similar decreases were observed for executive function scores (−0.38 [−0.58, −0.18], −0.11 [−0.20, −0.02] and −0.14 [−0.29, 0.01], respectively). When applying personalised exposure estimates, which were substantially lower, similar decreases were observed for composite memory score per IQR, but a consistent pattern of slightly more adverse effects with executive function score was evident. The present study constructed a framework through which time-activity information derived from a representative sample could be applied to estimates of ambient air pollution concentrations assigned to individuals in epidemiological cohort studies, with the intention of adjusting commonly used residence-based estimates to reflect population mobility and time spent in various microenvironments. Estimates of exposure were markedly lower when incorporating time-activity, likely because people in European populations spend a large proportion of their time indoors, where their exposure to ambient air pollution may be reduced through infiltration, which is not taken into account in residence-based ambient estimates. Further work into such methods could provide insights into the efficacy of personalising exposure estimates.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"36 1","pages":"33-40"},"PeriodicalIF":4.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41370-025-00745-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-11DOI: 10.1038/s41370-025-00743-9
Shayna C. Simona, Scott M. Bartell, Verónica M. Vieira
Children living in communities with lower socioeconomic status and higher minority populations are often disproportionately exposed to particulate matter (PM) compared to children living in other communities. We assessed whether adding HEPA filter air cleaners to classrooms with existing HVAC systems reduces indoor air pollution exposure. From July 2022 to June 2023, using a block randomized crossover trial of 17 Los Angeles Unified School District elementary schools, classroom PM concentrations were monitored and compared for 99 classrooms with HEPA filter air cleaners and 87 classrooms with non-HEPA filter air cleaners. In HEPA classrooms, average school-year PM2.5 was 39.9% lower (0.581 µg/m³; p < 0.001) and infiltration of outdoor PM2.5 into classrooms was 13.8–82.4% lower than non-HEPA classrooms, depending on the school.
{"title":"Classroom air quality in a randomized crossover trial with portable HEPA air cleaners","authors":"Shayna C. Simona, Scott M. Bartell, Verónica M. Vieira","doi":"10.1038/s41370-025-00743-9","DOIUrl":"10.1038/s41370-025-00743-9","url":null,"abstract":"Children living in communities with lower socioeconomic status and higher minority populations are often disproportionately exposed to particulate matter (PM) compared to children living in other communities. We assessed whether adding HEPA filter air cleaners to classrooms with existing HVAC systems reduces indoor air pollution exposure. From July 2022 to June 2023, using a block randomized crossover trial of 17 Los Angeles Unified School District elementary schools, classroom PM concentrations were monitored and compared for 99 classrooms with HEPA filter air cleaners and 87 classrooms with non-HEPA filter air cleaners. In HEPA classrooms, average school-year PM2.5 was 39.9% lower (0.581 µg/m³; p < 0.001) and infiltration of outdoor PM2.5 into classrooms was 13.8–82.4% lower than non-HEPA classrooms, depending on the school.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 4","pages":"644-648"},"PeriodicalIF":4.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/s41370-024-00742-2
Shiwen Li, Paulina Oliva, Lu Zhang, Jesse A. Goodrich, Rob McConnell, David V. Conti, Lida Chatzi, Max Aung
Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water and cancers can help inform biomonitoring and prevention efforts. To screen for incident cancer (2016–2021) and assess associations with PFAS contamination in drinking water in the US. We obtained county-level age-adjusted cancer incidence (2016–2021) from the Surveillance, Epidemiology, and End Results (SEER) Program. Data on PFAS levels in public drinking water systems were obtained from the Third (UCMR3; 2013–2015) and Fifth (UCMR5; 2023–2024) Unregulated Contaminant Monitoring Rule. UCMR3 measured PFOS, PFOA, PFNA, PFHxS, PFHpA, and PFBS. UCMR5 expanded measurements to include PFBA, PFHxA, PFPeA, and PFPeS. We created indicators of PFAS detection and, for UCMR5, concentrations above Maximum Contaminant Levels (MCLs). MCLs for PFOA and PFOS are 4 ng/L, and for PFNA and PFHxS are 10 ng/L. We used Poisson regression models to assess associations between PFAS detection or MCL violation and cancer incidence, adjusting for potential confounders. We estimated the number of attributable cancer cases. PFAS in drinking water was associated with increased cancer incidence in the digestive, endocrine, oral cavity/pharynx, and respiratory systems. Incidence rate ratios (IRRs) ranged from 1.02 to 1.33. The strongest association was observed between PFBS and oral cavity/pharynx cancers (IRR: 1.33 [1.04, 1.71]). Among males, PFAS was associated with cancers in the urinary, brain, leukemia, and soft tissues. Among females, PFAS was associated with cancers in the thyroid, oral cavity/pharynx, and soft tissue. PFAS in drinking water is estimated to contribute to 4626 [95% CI: 1,377, 8046] incident cancer cases per year based on UCMR3 data and 6864 [95% CI: 991, 12,804] based on UCMR5. The ecological study examined the associations between PFAS in drinking water measured in two waves (2013–2015 and 2023–2024) and cancer incidence between 2016 and 2021. We found that PFAS in drinking water was associated with cancers in the organ system including the oral cavity/pharynx, lung, digestive system, brain, urinary system, soft tissue, and thyroid. Some cancers have not been widely studied for their associations with PFAS. We also observed sex differences in the associations between PFAS and cancer risks. This is the first ecological study that examined PFAS exposure in drinking water and various cancer risks.
{"title":"Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States","authors":"Shiwen Li, Paulina Oliva, Lu Zhang, Jesse A. Goodrich, Rob McConnell, David V. Conti, Lida Chatzi, Max Aung","doi":"10.1038/s41370-024-00742-2","DOIUrl":"10.1038/s41370-024-00742-2","url":null,"abstract":"Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water and cancers can help inform biomonitoring and prevention efforts. To screen for incident cancer (2016–2021) and assess associations with PFAS contamination in drinking water in the US. We obtained county-level age-adjusted cancer incidence (2016–2021) from the Surveillance, Epidemiology, and End Results (SEER) Program. Data on PFAS levels in public drinking water systems were obtained from the Third (UCMR3; 2013–2015) and Fifth (UCMR5; 2023–2024) Unregulated Contaminant Monitoring Rule. UCMR3 measured PFOS, PFOA, PFNA, PFHxS, PFHpA, and PFBS. UCMR5 expanded measurements to include PFBA, PFHxA, PFPeA, and PFPeS. We created indicators of PFAS detection and, for UCMR5, concentrations above Maximum Contaminant Levels (MCLs). MCLs for PFOA and PFOS are 4 ng/L, and for PFNA and PFHxS are 10 ng/L. We used Poisson regression models to assess associations between PFAS detection or MCL violation and cancer incidence, adjusting for potential confounders. We estimated the number of attributable cancer cases. PFAS in drinking water was associated with increased cancer incidence in the digestive, endocrine, oral cavity/pharynx, and respiratory systems. Incidence rate ratios (IRRs) ranged from 1.02 to 1.33. The strongest association was observed between PFBS and oral cavity/pharynx cancers (IRR: 1.33 [1.04, 1.71]). Among males, PFAS was associated with cancers in the urinary, brain, leukemia, and soft tissues. Among females, PFAS was associated with cancers in the thyroid, oral cavity/pharynx, and soft tissue. PFAS in drinking water is estimated to contribute to 4626 [95% CI: 1,377, 8046] incident cancer cases per year based on UCMR3 data and 6864 [95% CI: 991, 12,804] based on UCMR5. The ecological study examined the associations between PFAS in drinking water measured in two waves (2013–2015 and 2023–2024) and cancer incidence between 2016 and 2021. We found that PFAS in drinking water was associated with cancers in the organ system including the oral cavity/pharynx, lung, digestive system, brain, urinary system, soft tissue, and thyroid. Some cancers have not been widely studied for their associations with PFAS. We also observed sex differences in the associations between PFAS and cancer risks. This is the first ecological study that examined PFAS exposure in drinking water and various cancer risks.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 3","pages":"425-436"},"PeriodicalIF":4.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-07DOI: 10.1038/s41370-024-00737-z
Jamie L. Banks, Becky Petrou O’Rourke
Aviation noise policy in the United States is decades old and has not kept up with the science on the adverse effects of chronic noise exposure. New aviation noise policies are needed for the 21st century, respecting the lived experience of affected communities. Existing surveys have reported adverse impacts from aviation noise but more information is needed to understand the factors that contribute to those impacts. To evaluate the impacts of current aircraft noise exposure on impacted communities and their determinants. A 10-question online community pilot survey was distributed in May 2022 to an email list of groups and individuals in aviation-impacted communities. The survey was open for two weeks. Information on geographic location, frequency of exposure, and type of aircraft exposure were collected. Seven questions focused on the type and magnitude of health impacts, perceptions, and concerns. A total of 1452 surveys were completed within the 2-week period. Respondents report experiencing loud, repetitive, low-altitude aircraft noise - day and night - causing stress and negative effects on mental and physical health. For many, “annoyance” did not adequately describe their experience. Strong, consistent exposure-response patterns for weekly flight frequency (<100 to >1000 flights) were found for most health impacts, perceptions, and concerns. The likelihood of adverse impacts and heightened perceptions and concerns was greatest in respondents exposed mainly to military aircraft. Current aviation noise policy is based on annoyance, and relies on a metric that exceeds safe levels and does not meaningfully convey community impact. Aviation-impacted communities are experiencing mental and physical health impacts that extend beyond annoyance. The magnitude of impact is influenced by flight frequency and aircraft type. Aviation noise policy should be updated to account for those factors and focus on reducing public health impacts and their human and economic costs. Aviation noise policy in the United States is decades old and is based solely on the concept of annoyance without sufficient regard to the harms caused to health and well-being of people living in aviation-impacted communities. Efforts to amend the policy must be informed by the scientific evidence on the adverse effects of noise and health and by metrics that properly represent the lived experiences of communities. The results of this pilot survey highlight the importance of incorporating these aspects into policy for preventing and mitigating harms caused by aviation noise, especially as the industry grows.
{"title":"Community impacts of aviation noise: a pilot survey","authors":"Jamie L. Banks, Becky Petrou O’Rourke","doi":"10.1038/s41370-024-00737-z","DOIUrl":"10.1038/s41370-024-00737-z","url":null,"abstract":"Aviation noise policy in the United States is decades old and has not kept up with the science on the adverse effects of chronic noise exposure. New aviation noise policies are needed for the 21st century, respecting the lived experience of affected communities. Existing surveys have reported adverse impacts from aviation noise but more information is needed to understand the factors that contribute to those impacts. To evaluate the impacts of current aircraft noise exposure on impacted communities and their determinants. A 10-question online community pilot survey was distributed in May 2022 to an email list of groups and individuals in aviation-impacted communities. The survey was open for two weeks. Information on geographic location, frequency of exposure, and type of aircraft exposure were collected. Seven questions focused on the type and magnitude of health impacts, perceptions, and concerns. A total of 1452 surveys were completed within the 2-week period. Respondents report experiencing loud, repetitive, low-altitude aircraft noise - day and night - causing stress and negative effects on mental and physical health. For many, “annoyance” did not adequately describe their experience. Strong, consistent exposure-response patterns for weekly flight frequency (<100 to >1000 flights) were found for most health impacts, perceptions, and concerns. The likelihood of adverse impacts and heightened perceptions and concerns was greatest in respondents exposed mainly to military aircraft. Current aviation noise policy is based on annoyance, and relies on a metric that exceeds safe levels and does not meaningfully convey community impact. Aviation-impacted communities are experiencing mental and physical health impacts that extend beyond annoyance. The magnitude of impact is influenced by flight frequency and aircraft type. Aviation noise policy should be updated to account for those factors and focus on reducing public health impacts and their human and economic costs. Aviation noise policy in the United States is decades old and is based solely on the concept of annoyance without sufficient regard to the harms caused to health and well-being of people living in aviation-impacted communities. Efforts to amend the policy must be informed by the scientific evidence on the adverse effects of noise and health and by metrics that properly represent the lived experiences of communities. The results of this pilot survey highlight the importance of incorporating these aspects into policy for preventing and mitigating harms caused by aviation noise, especially as the industry grows.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 1","pages":"80-90"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Exposure to per and poly-fluoroalkyl substances (PFAS) is suggested to interfere with the central nervous system that may affect mental health. Studies on the relationships between exposure to PFAS mixtures and anxiety in humans are rare. This study aimed to evaluate the associations between single and combined exposure to PFAS and anxiety among adults. Data were extracted from the National Health and Nutrition Examination Survey (NHANES, 2007–2012). Six serum PFAS concentrations were accessed including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), PFOS (perfluorooctanesulfonic acid), PFHxS (perfluorohexane sulfonate), PFDA (perfluorodecanoic acid), Me-PFOSA-AcOH (2-(N-methylperfluorooctanesulfonamide) acetic acid). The anxiety state was defined through the questionnaire responses of the participants. Weighted logistics regression was used to calculate their odds ratio (OR) and corresponding confidence interval (95% CI) that assessed the relationship between PFAS exposure and anxiety. Moreover, Two different statistical methods including quantile-based g-computation (Qgcomp), and Bayesian kernel machine regression (BKMR) were employed to investigate the overall effects of PFAS mixtures on anxiety. The effects of specific PFAS exposure on anxiety varied by sex. In male participants, one-unit increase in PFDA (OR = 0.62; 95%CI: 0.44, 0.88), PFOA (OR = 0.60; 95%CI: 0.41, 0.87), PFNA (OR = 0.68; 95%CI: 0.46, 0.96) concentrations were inversely linked to anxiety. In female participants, a one-unit increase in PFOA (OR = 1.50; 95%CI: 1.05, 2.14) concentration was associated with anxiety. Analysis of Qgcomp demonstrated that PFAS mixtures were negatively associated with anxiety in males (OR = 0.85; 95%CI: 0.74, 0.99), and were positively associated with anxiety in females(OR = 1.16; 95%CI: 1.01, 1.33). Analysis of BKMR suggested that PFAS mixtures were negatively associated with anxiety in the males, while its associations with anxiety were positive in the females.
{"title":"Sex specificity in associations between exposure to a mixture of per and poly-fluoroalkyl substances and anxiety among US adults","authors":"Xiaoguo Hua, Rui Hu, Cai Chen, Jiangjie Sun, Xiqiu Feng, Xiujun Zhang","doi":"10.1038/s41370-024-00741-3","DOIUrl":"10.1038/s41370-024-00741-3","url":null,"abstract":"Exposure to per and poly-fluoroalkyl substances (PFAS) is suggested to interfere with the central nervous system that may affect mental health. Studies on the relationships between exposure to PFAS mixtures and anxiety in humans are rare. This study aimed to evaluate the associations between single and combined exposure to PFAS and anxiety among adults. Data were extracted from the National Health and Nutrition Examination Survey (NHANES, 2007–2012). Six serum PFAS concentrations were accessed including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), PFOS (perfluorooctanesulfonic acid), PFHxS (perfluorohexane sulfonate), PFDA (perfluorodecanoic acid), Me-PFOSA-AcOH (2-(N-methylperfluorooctanesulfonamide) acetic acid). The anxiety state was defined through the questionnaire responses of the participants. Weighted logistics regression was used to calculate their odds ratio (OR) and corresponding confidence interval (95% CI) that assessed the relationship between PFAS exposure and anxiety. Moreover, Two different statistical methods including quantile-based g-computation (Qgcomp), and Bayesian kernel machine regression (BKMR) were employed to investigate the overall effects of PFAS mixtures on anxiety. The effects of specific PFAS exposure on anxiety varied by sex. In male participants, one-unit increase in PFDA (OR = 0.62; 95%CI: 0.44, 0.88), PFOA (OR = 0.60; 95%CI: 0.41, 0.87), PFNA (OR = 0.68; 95%CI: 0.46, 0.96) concentrations were inversely linked to anxiety. In female participants, a one-unit increase in PFOA (OR = 1.50; 95%CI: 1.05, 2.14) concentration was associated with anxiety. Analysis of Qgcomp demonstrated that PFAS mixtures were negatively associated with anxiety in males (OR = 0.85; 95%CI: 0.74, 0.99), and were positively associated with anxiety in females(OR = 1.16; 95%CI: 1.01, 1.33). Analysis of BKMR suggested that PFAS mixtures were negatively associated with anxiety in the males, while its associations with anxiety were positive in the females.","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":"35 4","pages":"578-589"},"PeriodicalIF":4.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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