Journal of Environmental Sciences-china最新文献

{"title":"Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging","authors":"Gang Wei ,&nbsp;Wangrui Liu ,&nbsp;Fengjie Shen ,&nbsp;Rongrong Xie ,&nbsp;Fengwei Wang ,&nbsp;Huaqi Guo ,&nbsp;Lin Liu","doi":"10.1016/j.jes.2025.05.036","DOIUrl":"10.1016/j.jes.2025.05.036","url":null,"abstract":"<div><div>The global rise in intestinal dysfunction has been linked to modifiable risk factors including high-fat diet (HFD)-induced obesity/diabetes, microplastics (MPs) and aging, yet their combined effects remain unclear. This study examined the combined effects of chronic low dose polystyrene MPs (∼25 μg/(kg·day)) with HFD or aging on intestinal barrier function in C57BL/6 J mice over 14 weeks. Juvenile mice receiving either normal chow (NCD) or HFD, along with aged NCD-fed mice, were subjected to MPs exposure. Results demonstrated that MPs exposure or HFD feeding (and aging) significantly exacerbated the pathological changes developed in colon tissues of mice relative to those of control mice, including gut permeability, oxidative stress, pro-inflammatory response and apoptosis. Moreover, combination of MPs exposure with HFD feeding (and aging) further potentiated the harmful effects on colon dysfunctions, clearly showing a synergistic deterioration effect (‘double hit’). More importantly, we found that the recovery of colon damages resulting from MPs exposure and HFD feeding was disrupted after their withdrawal, leading to the worse effects on gut microbiota dysbiosis and intestinal function. Furthermore, oral administration of <em>Akkermansia muciniphila</em> prevented intestinal barrier dysfunction and decreased intestinal permeability from MPs exposure and HFD feeding co-exposure. Our findings in this study emphasized the important role of avoiding MPs exposure in the prevention and treatment of intestinal-related dysfunctions, and provided potential therapeutic approaches. The oral administration of gut microbiota, such as <em>Akkermansia muciniphila</em>, contributed to restoration of intestinal barrier function, uncovering a new landscape for treating intestinal disabilities caused by MPs exposure.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 430-443"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular ecological networks reveal intensified competition of anammox consortia under quinoline pressure","authors":"Mei Hu ,&nbsp;Xuejiao Wang ,&nbsp;Gengyi Zhang ,&nbsp;Daoguang Lu ,&nbsp;Yan Zhang ,&nbsp;Junyu Liu ,&nbsp;Tao Ya ,&nbsp;Quan Zheng ,&nbsp;Xiaohui Wang","doi":"10.1016/j.jes.2025.06.003","DOIUrl":"10.1016/j.jes.2025.06.003","url":null,"abstract":"<div><div>Anammox process with greatly saving energy consumption is a promising technology to remove nitrogen from wastewater. Quinoline is a common organic pollutant in wastewater, its effect on the microbial interaction in anammox system, however, still remains unclear. This study systematically investigated the impact of exogenous quinoline on system performance and elucidated underlying microbial response mechanisms using molecular ecological networks (MENs) analysis. We found that 10 mg/L quinoline inhibited the NH₄⁺-N nitrogen removal from 97.1 % to 80 %. Quinoline also improved deterministic mechanisms involved in community assembly. MENs analysis showed that quinoline reduced the overall network size and complexity. Competitive interaction was significantly enhanced from 54.5 % to 80.0 % between ammonia oxidizing bacteria and other bacteria in subnetwork, particularly denitrifying bacteria <em>Thauera</em> and <em>Ignavibacterium</em>, which could be responsible for the deteriorating nitrogen removal efficiency. Meanwhile, <em>Anaerolinea</em> (ASV1121) was identified as a keystone species at 10 mg/L quinoline, which could play an active role in the degradation of refractory organics. This paper enriches our understanding of the microbial interactions within the system in response to quinoline exposure, and provides technical support for the treatment of quinoline-containing wastewater by Anammox process.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 395-404"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photo-release of dissolved organic matter from soil-derived sources: An insight into the impact of acid mine drainage","authors":"Lezhang Wei ,&nbsp;Fangqing Li ,&nbsp;Yu Liu ,&nbsp;Qihang Wu ,&nbsp;Chengjun Zhang ,&nbsp;Xuexia Huang ,&nbsp;Dinggui Luo ,&nbsp;Juan Liu ,&nbsp;Tangfu Xiao","doi":"10.1016/j.jes.2025.05.023","DOIUrl":"10.1016/j.jes.2025.05.023","url":null,"abstract":"<div><div>Particulate organic matter (POM) serves as a significant photo-induced source of dissolved organic matter (DOM), which plays a critical role in the biogeochemical behavior of potentially toxic elements in rivers affected by acid mine drainage (AMD). However, the photochemical reactions of POM in AMD have been underexplored. This study provides insights into the influence of AMD on the photo-release of DOM from soil-derived POM under simulated irradiation conditions. The spectroscopic and molecular composition of DOM was characterized and water quality parameters such as total organic carbon (TOC) and the concentrations of Fe(II) and Fe(III) was quantified in the experimental solutions with varying ratios of AMD addition (i.e., 0 %, 0.0 %, 0.05 %, 0.1 %, 0.5 %, 1 % AMD). The results indicate that photoirradiation caused an increase in carbon loss from POM in the solutions through the processes of photo-dissolution and photodegradation. Initially, a larger fraction of tyrosine-like, saturated compounds predominated the DOM components in the solutions, which were subsequently replaced by lignin-like classes after 12 h of photoirradiation. The addition of AMD significantly enhanced the photochemical reactions, resulting in a shift in DOM toward more aromatic molecules, as characterized by higher ratios of O/C, aromaticity index (AI_mod), double bond equivalents (DBE), and nominal oxidation state of carbon (NOSC), alongside lower H/C values. Although the addition of AMD markedly increased the photodegradation of lignins and tannins, our findings suggest that the photochemical reactions of dissolution and degradation generated DOM that diverged from well-documented results during a singular process of DOM photodegradation, which typically indicates that humic-like components are preferentially lost and that the newly leached DOM contains a significant proportion of aliphatic compounds. Additionally, our results demonstrated that the mineralization of POM-derived DOM was associated with the photoreduction of Fe(III), as evidenced by elevated levels of Fe(II) (eightfold increase following photoirradiation in the 1 % AMD treatment group) and diminished concentrations of dissolved organic carbon (DOC) (4.65 mg/L and 3.74 mg/L in the 0 % AMD and 1 % AMD treatment groups, respectively) in the AMD-rich solutions. This investigation contributes to a deeper understanding of the photo-transformation of POM and DOM during instream transport and the biogeochemical processes of key elements in rivers impacted by AMD.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 322-331"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of microplastics in landfill leachate: An underestimated tiny microplastics using Focal Plane Array (FPA)-based Fourier Transform Infrared (FTIR) imaging","authors":"Shijie Bian ,&nbsp;Timing Jiang ,&nbsp;Jingwei Yan ,&nbsp;Rui Cai ,&nbsp;Shushan Yuan ,&nbsp;Wenbo Yu ,&nbsp;Sha Liang ,&nbsp;Liang Huang ,&nbsp;Huabo Duan ,&nbsp;Mukesh Kumar Awasthi ,&nbsp;Jiakuan Yang","doi":"10.1016/j.jes.2025.05.068","DOIUrl":"10.1016/j.jes.2025.05.068","url":null,"abstract":"<div><div>Landfills are significant contributors to the generation of microplastics (MPs) in the environment. However, how to accurately identify and quantify tiny MPs (10–100 μm) in landfill leachate remains an ongoing challenge. The identification of MPs in the leachate of operating and closed landfills was comparatively investigated using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) and focal plane array-based micro-Fourier-transform infrared (FPA-FTIR) imaging. The abundance of MPs detected by FPA-FTIR (70–235 items/L) was two-order magnitude higher than that by ATR-FTIR (2–7 items/L), indicating that FPA-FTIR was more efficient in detecting tiny MPs than ATR-FTIR. Furthermore, the MPs in landfill leachate from 13 different landfills in China, comprising both operating and closed landfills, were determined by FPA-FTIR. The morphology of MPs mainly consists of white fragments, and they are predominantly high-density engineering plastics, which make up 90 % of the total MPs. In operating landfills, the abundance of MPs ranged from 175 to 5320 items/L. The abundance initially increased to a maximum peak at around 15 years of landfill age, and then declined as the landfill continued to operate. In closed landfills, the abundance of MPs showed a decreasing trend with the increasing of landfill closure age. The operational conditions and landfill age significantly affect the quantity of MPs in leachate; however, they do not exert a notable influence on the morphological characteristics of MPs in leachate. This study provided valuable insights for evaluating the transportation and migration behavior of MPs from landfill cells into leachate.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 199-208"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anode-dependent selectivity and formation mechanisms of inorganic chlorinated byproducts in electrochemical advanced oxidation processes","authors":"Omidele Oluwafemi Benjamin ,&nbsp;Xinqing Liao ,&nbsp;Jinlong Fan ,&nbsp;Mingyuan Wang ,&nbsp;Adenike Bernice Eloise Adeoye ,&nbsp;Olusegun K. Abass ,&nbsp;Yao-Yin Lou ,&nbsp;Shaohua Chen ,&nbsp;Xiaojun Wang","doi":"10.1016/j.jes.2025.09.014","DOIUrl":"10.1016/j.jes.2025.09.014","url":null,"abstract":"<div><div>Anode materials significantly affect Cl-species evolution in electrochemical advanced oxidation process (EAOP) for wastewater treatment. This study investigated the formation of inorganic chlorinated byproducts and the oxidation mechanisms using four anode materials: Ir-Ta@Ti and Ru-Ir-Sn@Ti as active anodes, and PbO₂ and boron-doped diamond (BDD) as non-active anodes. The results showed that active chlorine was the dominant byproduct in the Ir-Ta@Ti and Ru-Ir-Sn@Ti systems, whereas ClO₃⁻ and ClO₄⁻ were predominantly formed in the PbO₂ and BDD systems, respectively. These byproducts accounted for approximately 92 %, 98 %, 67 %, and 89 % of the initial Cl⁻ concentration of 607 mg/L at 120 min with a current density of 40 mA/cm². Kinetic rate constants for each chlorinated byproduct were provided. The quenching test demonstrated direct electron transfer was the primary oxidation pathway in the Ir-Ta@Ti and Ru-Ir-Sn@Ti systems, responsible for producing ClO⁻as the primary chlorinated byproduct from Cl⁻. In contrast, the PbO₂ system facilitated ClO₃⁻ formation primarily through a multi-electron transfer from Cl⁻ to ClO₂⁻, followed by further oxidation to ClO₃⁻. In the BDD system, indirect oxidation played a dominant role in generating ClO₄⁻. Notably, despite substantial ^•OH concentration being detected in PbO₂ system, ClO₄⁻ was barely formed, likely due to no ClO₃⁻ absorbed on the surface to produce ClO₃^•. The preferred chlorinated byproducts and the corresponding oxidation mechanism for each anode are summarized. It suggests selecting appropriate anodes based on their oxidizing capacity and chlorinated byproduct. This study provides insight into controlling the production of undesirable chlorinated byproducts in EAOP.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 240-248"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of multiple reservoirs on hydrological cycle and hydrochemical evolution in a mountainous river basin of the North China Plain","authors":"Pinna Zhen ,&nbsp;Fei Liu ,&nbsp;Xiaoshuai Guo ,&nbsp;Yanhui Guo","doi":"10.1016/j.jes.2025.09.020","DOIUrl":"10.1016/j.jes.2025.09.020","url":null,"abstract":"<div><div>River fragmentation resulting from increasing reservoirs worldwide greatly disrupts natural hydrological processes and concomitant hydrogeochemical evolution, but the knowledge of river-groundwater interaction in this context is still poorly understood. To fill this gap, this study selects the Upper Zhanghe River, a headwater basin of the North China Plain, to identify the river-groundwater interplay and hydrochemical evolution impacted by three large reservoirs. A total of 107 water samples were collected during two sampling campaigns for chemical and stable isotopic analysis. Results showed that reservoirs interrupted the general pattern of isotopic enrichment along flow direction, and the heaviest isotopes were observed in three large reservoirs. Guanhe Reservoir’s downstream river water was jointly recharged by adjacent groundwater (∼76 %) and reservoir water (∼24 %). Houwan Reservoir and groundwater contributed to ∼78 % and ∼22 % of downstream river water. Zhangze Reservoir’s downstream groundwater was marginally recharged (∼17 %) by the river water. Chemical signals showed that river water followed a progressive accumulation in salinity from upstream through reservoir to downstream. The evolution of river water types from upper reach (Ca-HCO₃ and Na-HCO₃) to lower reach (Ca-Na-HCO₃ and Na-Ca-SO₄-Cl) was closely related to reservoir water chemistry (Ca-Na-HCO₃ and Na-Ca-mixed anions). However, the riparian groundwater hydrochemical types (Ca-HCO₃) were not significantly affected by three large reservoirs and river water. Groundwater chemical evolution was mainly controlled by dedolomitization, the evaporites’ weathering, cation exchange, and anthropogenic pollutants. These findings contribute to future integrated management of multiple water sources in river basins worldwide regulated by large reservoirs.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 784-798"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic interactions among ramie (Boehmeria nivea L.), earthworm (Eisenia fetida), and soil microbials in phytoremediation on soil cadmium absorption","authors":"Kaiye Li ,&nbsp;Chao Zeng ,&nbsp;Junliang Liu ,&nbsp;Qing Chen ,&nbsp;Min Zheng ,&nbsp;Yifeng Xu ,&nbsp;Chensheng Lu","doi":"10.1016/j.jes.2025.06.059","DOIUrl":"10.1016/j.jes.2025.06.059","url":null,"abstract":"<div><div>Soil contamination by heavy metals have been ubiquitously present worldwide, therefore, identifying a native, effective, and sustainable approach for remediation is imperative. This randomized block pot experiment was designed to experiment an earthworm-assisted ramie-based phytoremediation to test the hypothesis that the presence of earthworms could significantly enhance the efficacy of cadmium (Cd) absorption by ramie. In the current study, we have demonstrated earthworms, in particular anthocyanin-fed earthworms, can facilitate ramie-based phytoremediation and significantly increased the total Cd accumulation in ramie for both 3 mg/kg Cd and 20 mg/kg Cd fortified soils, by 107 % and 99 %, respectively. This was achieved through providing significant contributions to improve soil properties, increase the abundance of Cd-resistant genes, reduce the abundance of denitrification gene, directly or indirectly influence the bioavailability of Cd and eventually increase the uptake of Cd by ramie. Without any foreseeable disadvantages, this approach offers a viable solution that leverages biological synergies within the soil ecosystem to ensure the success of phytoremediation and environmental sustainability.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 687-695"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics containing plasticizers affect chicken reproduction via disturbing ovary DNA homologous recombination activity","authors":"Jiaping Xu,&nbsp;Zhipeng Cheng,&nbsp;Yu Wang,&nbsp;Qiuyue Zhang,&nbsp;Hongkai Zhu,&nbsp;Hongzhi Zhao,&nbsp;Yiming Yao,&nbsp;Lei Wang,&nbsp;Hongwen Sun","doi":"10.1016/j.jes.2025.05.009","DOIUrl":"10.1016/j.jes.2025.05.009","url":null,"abstract":"<div><div>Microplastics (MPs) alone or carrying organic contaminants (OCs) have been proven to exhibit a wide range of toxic effects on aquatic animals. Nevertheless, the impacts and mechanisms for co-exposure to MPs and OCs on vertebrate animals remain obscure. This study investigated the impact of clean and phthalate esters (PAEs)-spiked MPs on chicken by observing the egg-laying behavior, analyzing the levels of PAEs and their metabolites in eggs, as well as exploring the gene expression in ovaries. Results showed that 16 eggs were collected from the 10 %-spiked MPs group during depuration period though no eggs production during exposure period. The finding suggested that the impaired ovarian functions and egg-laying behavior gradually improved once the exposure ceased. Concurrent chemical analysis indicated that the damage extent to ovarian development was highly correlated with the accumulation and elimination of PAEs and their metabolites. The depuration period led to a 97.5 % reduction in di-(2-ethylhexyl) phthalate concentrations in ovarian yolk relative to the exposure period. Additionally, parent PAEs were more inclined to accumulate in egg yolk, while their metabolites were mainly enriched in egg white. Furthermore, the transcriptomic analysis revealed that PAEs-spiked MPs induced significant gene expression changes and activated DNA homologous recombination in ovaries (26 up-regulated and 3 down-regulated genes), leading to delayed ovarian development. Overall, this study provides new insights into the reproductive toxicity and corresponding molecular mechanisms of MPs and PAEs, alarming the potential risks to animal health and human food safety from these pollutants in poultry.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 654-662"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the potential of Bacillus cereus HS-9 in cadmium bioremediation and ensuring rice safety","authors":"Mengmeng Wang ,&nbsp;Jiayin Zhao ,&nbsp;Jianan Gao ,&nbsp;Sibo Cai ,&nbsp;Yongjing Gu ,&nbsp;Yu Liu ,&nbsp;Li Gao ,&nbsp;Yu Xu ,&nbsp;Yuncheng Wu ,&nbsp;Zhengtong Zhou ,&nbsp;Jibing Zhang ,&nbsp;Wei Tian","doi":"10.1016/j.jes.2025.05.044","DOIUrl":"10.1016/j.jes.2025.05.044","url":null,"abstract":"<div><div>Cadmium (Cd) contamination in agricultural soils poses significant environmental and health risks due to its non-degradable and bio-magnifying nature. With the global imperative for eco-friendly Cd remediation strategies, microbial bioremediation emerges as a promising approach. Here, <em>Bacillus cereus</em> HS-9 was isolated from Cd-contaminated paddy soil using LB medium supplemented with 5 mg/L of Cd. HS-9 exhibited an impressive Cd removal efficiency of 95.44 % at a concentration of 5 mg/L. A rice pot experiment was conducted using Cd-contaminated soil, with HS-9 inoculation as the treatment group and non-inoculated soil as the control. The treatment group resulted in a 38.99 % reduction in soil Cd availability and a 34.33 % decrease in rice Cd content without affecting rice yield. The microbial community of the rice rhizosphere was analyzed using metagenome sequencing. The results revealed an increased abundance of <em>czcA, frnE</em>, and <em>irlS</em> genes in the soil microbiome, indicating enhanced Cd resistance and efflux capabilities. Microbial community showed significant shifts towards a beneficial microbial consortium, particularly marked by increases in <em>Lysobacter</em> and <em>Sphingomonas</em> genera which are known for their roles in heavy metal resistance and bioremediation. <em>B. cereus</em> HS-9 demonstrated significant potential for the bioremediation of Cd-contaminated soil. This study provides foundation for the development of microbial-based strategies for the eco-friendly remediation of heavy metal-polluted agricultural lands.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 573-583"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of amoxicillin on cartilage and bone development in zebrafish and their molecular mechanisms","authors":"Fei Long ,&nbsp;Yangfan Shangguan ,&nbsp;Jiaqi Wang ,&nbsp;Hui Wang ,&nbsp;Liaobin Chen","doi":"10.1016/j.jes.2025.06.044","DOIUrl":"10.1016/j.jes.2025.06.044","url":null,"abstract":"<div><div>Amoxicillin, a beta-lactam antibiotic, is the preferred treatment for numerous common infections during pregnancy. However, it has been identified as an emerging environmental pollutant. Clinical and animal studies indicate that prenatal exposure to amoxicillin may pose fetal developmental toxicity risks. In view of the environmental exposure and clinical application status of amoxicillin, this study investigated the effects of amoxicillin exposure at different concentrations and embryonic stages on the overall development of zebrafish embryos, as well as the development of cartilage and bone, and their underlying mechanisms. Our findings revealed that embryonic exposure to amoxicillin inhibited the overall, cartilage, and bone development of zebrafish in a concentration (80–400 µmol/L) and stage (0–1.5 and 1.5–3.0 dpf) dependent manner. This inhibition was manifested as reduced head and body length, decreased head and eye area, shortened palatal and ceratohyal cartilage length, and diminished operculum bone area, with these effects persisting from the larval to the juvenile stage. Notably, early exposure to amoxicillin had a more pronounced impact on zebrafish embryonic cartilage development, attributed to the inhibition of the <em>foxo3a</em> signaling pathway. In contrast, late exposure to amoxicillin more significantly affected zebrafish embryonic bone development, associated with the inhibition of the <em>jak2a</em>/<em>stat3</em> signaling pathway. This study has verified the toxicity of amoxicillin to cartilage and bone development and elucidated its potential mechanisms, providing a theoretical and experimental basis for evaluating the environmental exposure risk of amoxicillin and revealing its action patterns.</div></div>","PeriodicalId":15788,"journal":{"name":"Journal of Environmental Sciences-china","volume":"162 ","pages":"Pages 562-572"},"PeriodicalIF":6.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}