Background
In ferrets, osteomas are rare, benign bone-originating tumors that can lead to detrimental clinical signs which negatively impact their quality of life. To date, current reported successful treatments include complete surgical excision for curative intent. Surgical debulking and subsequent radiotherapy was a novel approach to treatment employed in this case.
Case description
A 10-month-old, neutered male, sable ferret (Mustela putorius furo) presented with a firm, immobile, subcutaneous mass (15.6 mm x 14.0 mm x 16.0 mm; rostrocaudal x mediolateral x dorsoventral) originating from the lateral margin of the angle of the left mandible based on computed tomographic (CT) scan. Surgical debulking was performed and the mass was confirmed to be an osteoma on histopathology. To follow, stereotactic radiotherapy was prescribed to treat the residual mandibular mass effect with 8 Gy delivered each day for 3 sequential days (total dose of 24 Gy). There were no apparent early or late adverse effects of radiation and no regrowth was appreciated clinically or on CT scans 141 days post-surgery (106 days post-radiotherapy) and 403 days post-surgery (368 days post-radiotherapy). The ferret died approximately 2 years post-operation due to unknown cause without obvious regrowth of the mandibular mass at the time of death.
Conclusions and case relevance
In this ferret, the combination of surgical debulking and stereotactic radiotherapy resulted in a clinical cure of a mandibular osteoma for at least 2 years. Additional studies with a larger sample size may further elucidate early and late radiation side effects, surgical complications, and long-term outcome.
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